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<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZQ8</accession>
    <name>A0A182NZQ8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ion transport peptide-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZQ8"/>
    <dbReference type="STRING" id="199890.A0A182NZQ8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000139-RA">
        <property type="protein sequence ID" value="AEPI000139-PA"/>
        <property type="gene ID" value="AEPI000139"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000139"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2010.10:FF:000001">
        <property type="entry name" value="Ion transport peptide isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2010.10">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031098">
        <property type="entry name" value="Crust_neurohorm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035957">
        <property type="entry name" value="Crust_neurohorm_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001166">
        <property type="entry name" value="Hyperglycemic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981:SF2">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01147">
        <property type="entry name" value="Crust_neurohorm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00550">
        <property type="entry name" value="HYPRGLYCEMIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81778">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="3"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR631098-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000139-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="13171" checksum="71DEB8A7E4FE6AAE" modified="2016-09-07" version="1">MECKGQFNKQIFYRLDRICEDCYSLFREPQILSFCKKQCFTTDYFKGCIDALQLTDEIEKFKPLIKVLNGADPNTEGCFGTDYFLACVEALFLEEEKEKFMKWREMLGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P071</accession>
    <name>A0A182P071_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 3'-phospho 5'-phosphosulfate transporter 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P071"/>
    <dbReference type="STRING" id="199890.A0A182P071"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000303-RA">
        <property type="protein sequence ID" value="AEPI000303-PA"/>
        <property type="gene ID" value="AEPI000303"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000303"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF13">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000303-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="477" mass="53551" checksum="66A909D1E791A968" modified="2016-09-07" version="1">MRNYVPDIIILFIVIVTITIVRLVSQILHETLSDGPPDLIVPPAEGAPPKPELSLSQLIDQKSKEYSWLLRLLVNLFGYLCIFVPGVLIYKYAKRTKYIDRSERSHLSALVKFCFSGSGSDSLDRPLDGPSGGGKGATSKRTTAQECALLCYCLVGLMGSYLTWGVLQEKIMTQEYEGPEKRKSHFKDSQFLVFSNRVLGFMITAVYLVAKRQFRHRAPLYKYSFASFSNIMSAWFQYEALKFVNFPTQVLAKSCKIIPVMIMGKIISRNKYEFYEYLTAVMISVGMIFFLTGSTDESKSTAMTTLTGVLLLTFYMIFDSFTSNWQGELFKSYSMSSIQMMCGVNLFSTLFTGASLAMQGGFYSSLVFAVDHPKFVIDCVVLSISSAIGQLFIFYTIATFGAVVFTIIMTLRQAFAILLSCLIYQHRISFLGVVGVLIVFLAIFLRVYCNQRLKAIKQRHLQNAQAGISGSKPRINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0A4</accession>
    <name>A0A182P0A4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0A4"/>
    <dbReference type="STRING" id="199890.A0A182P0A4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000336-RA">
        <property type="protein sequence ID" value="AEPI000336-PA"/>
        <property type="gene ID" value="AEPI000336"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000336"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
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        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Regena, isoform C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
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        <property type="entry name" value="Not2/3/5"/>
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        <property type="entry name" value="NOT2/3/5_C"/>
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        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="437"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="43"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
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            <begin position="105"/>
            <end position="132"/>
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            <begin position="133"/>
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            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
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        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000336-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="578" mass="58837" checksum="FC3FF9D1B8BFC0C4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0D0</accession>
    <name>A0A182P0D0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the CIA complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P0D0"/>
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        <property type="protein sequence ID" value="AEPI000362-PA"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI000362"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="AGAP003548-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 N-terminal" evidence="14">
        <location>
            <begin position="378"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="13">
        <location>
            <begin position="900"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000362-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1290" mass="145087" checksum="8652BEE6F78D4B44" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0S3</accession>
    <name>A0A182P0S3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0S3"/>
    <dbReference type="STRING" id="199890.A0A182P0S3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000505-RA">
        <property type="protein sequence ID" value="AEPI000505-PA"/>
        <property type="gene ID" value="AEPI000505"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000505"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:autophagosome assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="serine/threonine-protein kinase unc-51 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000505-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="132" mass="14614" checksum="F5E72BFE937D35E7" modified="2016-09-07" version="1">MEIVGSFEYNSKEIIGHGAFAVVFKGRHREAHYPVAIKSITKKSLAKSQSLLGKEIKILQELSALKHKNVVKLLACTEKDQNVFLVMEKLCATNGNRLPRAEGCCADDAKRVSTPKVTFKLLKRFVSTGPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1K7</accession>
    <name>A0A182P1K7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P1K7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000789-RA">
        <property type="protein sequence ID" value="AEPI000789-PA"/>
        <property type="gene ID" value="AEPI000789"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000789"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000327">
        <property type="entry name" value="ATP-binding cassette sub-family A member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="896"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1067"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1117"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1146"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1210"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1282"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1892"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1935"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1975"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2006"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2079"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2535"/>
            <end position="2556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2706"/>
            <end position="2726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2747"/>
            <end position="2773"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="521"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1352"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="2161"/>
            <end position="2391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2129"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2140"/>
            <end position="2150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000789-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2796" mass="314244" checksum="81345FC0C806FDBA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1L8</accession>
    <name>A0A182P1L8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1L8"/>
    <dbReference type="STRING" id="199890.A0A182P1L8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000800-RA">
        <property type="protein sequence ID" value="AEPI000800-PA"/>
        <property type="gene ID" value="AEPI000800"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000800"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08387">
        <property type="entry name" value="C2A_Synaptotagmin-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00276">
        <property type="entry name" value="C2B_Synaptotagmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000223">
        <property type="entry name" value="Synaptotagmin alpha, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000211">
        <property type="entry name" value="synaptotagmin-5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF373">
        <property type="entry name" value="MIP05618P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="225"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="357"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000800-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="509" mass="55862" checksum="1CA1858B1F9CAD91" modified="2016-09-07" version="1">MKSPIASWFSQADGVNPTQIAIYGSVSFLVVSLVGLLIYITCSKRYRLNWYEKNLLESAKEREAAQRSSHEGHITCPIAYNVDAVAGTSRYLNRAHGSPQTRPDHPPFWASQGLYRKSDSRGQLIDTSDEETTGEDSGDSAGSSSRSVIAAPCGAVAIASTGKHVVLVTSSPAKPTTAMVSTVAGATTAAGGGAVKGDGQARIDMVDSASTCSTVSRDELGGEDARGAIHLTLSYDPAAGILNVKLVEAQDLQPQDFSGTADPYAKIRLLPDRNNMWQTRIHKKTLNPVFDEDFVFEVRSATIGRRTLEILLFDFDAYSRHVCIGGVQFPLAQVCLAERIDIWRPLLPYTEQDNKQDLGDLMVSLSYQPAAEKLTVVIIKARNLRVIDGTRNSSDPYVKVCLYNADGRRIKKRKTTVARNTTAPVYNEALTFDISRETLRDCSIEFQVLHDSLLGKNETLGRATVGSGPEFRQENRKFFDELFRTRAATAQWISLCELKLKSDTPSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1Z4</accession>
    <name>A0A182P1Z4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1Z4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000928-RA">
        <property type="protein sequence ID" value="AEPI000928-PA"/>
        <property type="gene ID" value="AEPI000928"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000928"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000928-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="175" mass="19889" checksum="9A93EFBB3117AD87" modified="2016-09-07" version="1">MDKYLRRFIKYQTYMIVIVTLEMVLLLTPAIADFEVNHFENLRFGGKVAIIFGVIWFFAVMSLIKAIHCEDKRFIYPYAFVFGLDLSLQVLREIYLIMLEGLDGLIVIKLLVAVLVVPYVFASLFALHRLFTVDPVGNHRSEGFVRFDRNELTVVEEGQISSTSGPANPSAPPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2D5</accession>
    <name>A0A182P2D5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TRAF3-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAF3IP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2D5"/>
    <dbReference type="STRING" id="199890.A0A182P2D5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001069-RA">
        <property type="protein sequence ID" value="AEPI001069-PA"/>
        <property type="gene ID" value="AEPI001069"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001069"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.50:FF:000001">
        <property type="entry name" value="TRAF3-interacting protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.50">
        <property type="entry name" value="Microtubule-binding protein MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018799">
        <property type="entry name" value="TRAF3IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041476">
        <property type="entry name" value="TRAF3IP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040468">
        <property type="entry name" value="TRAF3IP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042576">
        <property type="entry name" value="TRAF3IP1_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363:SF0">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10243">
        <property type="entry name" value="MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17749">
        <property type="entry name" value="MIP-T3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAF3-interacting protein 1 N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF3-interacting protein 1 C-terminal" evidence="13">
        <location>
            <begin position="516"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="558"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001069-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="668" mass="74344" checksum="0CF3A94214DFC77A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2T3</accession>
    <name>A0A182P2T3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2T3"/>
    <dbReference type="STRING" id="199890.A0A182P2T3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001219-RA">
        <property type="protein sequence ID" value="AEPI001219-PA"/>
        <property type="gene ID" value="AEPI001219"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001219"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF220">
        <property type="entry name" value="LD41874P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="115"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001219-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="309" mass="35873" checksum="458DCA38A775F0EA" modified="2016-09-07" version="1">MALQYDEQKVPFVDFGNGVKLQLSLEEFTDAASKEKAAKELRETAEVMEESIRKLRELVDQEKQLKLPVEDESFMKRFLRPKKYYPESTFDMMKAFYQMKAKANFISDQLTTHSIQNALEDRVVQILPKRDQHGRRILYMEMGAKWNCTKVPSLEVIRCTNMLMEAIGREPATQLSGVVFIINFDKLSLSHISQFPPKFVKTVVDHGQKNSPYRIKGMHIVNNARMFNIFFKIFKPFLGKKWSQRIFLHGVELKALHDHIDPDCLPSFLGGAYELPAYEGAVIGQLLDCYKEKFEEEEKYGYIAEVKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2Y6</accession>
    <name>A0A182P2Y6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2Y6"/>
    <dbReference type="STRING" id="199890.A0A182P2Y6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001273-RA">
        <property type="protein sequence ID" value="AEPI001273-PA"/>
        <property type="gene ID" value="AEPI001273"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001273"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000075">
        <property type="entry name" value="RWD domain-containing protein (Gir2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="11"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001273-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="240" mass="28038" checksum="4D330182D1C5D18E" modified="2016-09-07" version="1">MERNHREDQCNEIEALDSIYCGELEVLETEPHKFRLPIATTEYDPEVETEGLSCKLLFTYTEKYPDTAPLVEIEEPVNFQDSYEEELLEHIHKTIEENIGIEMIFSLVSSAQEWLNVKYDELKNAAETAKEEAKRRVEEEEMKKFEGTRVTVESFMAWKLKFEQDMGITERKEKVAAESRKLTGRELFLSDNTLNESDLKFLMDAGEPIENVRIDESLFQNIDDLDLDSDDEDDEDYVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2Z0</accession>
    <name>A0A182P2Z0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A182P2Z0"/>
    <dbReference type="STRING" id="199890.A0A182P2Z0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001277-RA">
        <property type="protein sequence ID" value="AEPI001277-PA"/>
        <property type="gene ID" value="AEPI001277"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001277"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF472">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="92"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001277-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="300" mass="34571" checksum="22E62E4743C06948" modified="2016-09-07" version="1">MPEEEIRALCLKSREIFLQQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPIAAIIDEKIFCCHGGLSPDLNHMEQIKRIMRPTDVPDTGLLCDLLWSDPDKDVKGWGENDRGVSFTFGVDIVAKFLLIHELDLICRAHQVVEDGYEFFARRSLVTLFSAPNYCGEFDNAGGMMSVDANLMCSFQILKPSEKKAKYQYSGTNNQRPQTPQRNQNPTNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3C5</accession>
    <name>A0A182P3C5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3C5"/>
    <dbReference type="STRING" id="199890.A0A182P3C5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001410-RA">
        <property type="protein sequence ID" value="AEPI001410-PA"/>
        <property type="gene ID" value="AEPI001410"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001410"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130763" evidence="1">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001410-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="81" mass="9586" checksum="B0D6B4902F718181" modified="2016-09-07" version="1">MELPRSRWWRWRRRHLLTGSLLLLVCLLLAFDPAPVKADPDEDIPHNEVRNWAIRFGVDLWEFGRQFTKVADIRSVSICSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3E7</accession>
    <name>A0A182P3E7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. C/EBP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3E7"/>
    <dbReference type="STRING" id="199890.A0A182P3E7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001432-RA">
        <property type="protein sequence ID" value="AEPI001432-PA"/>
        <property type="gene ID" value="AEPI001432"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001432"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF69">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001432-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="163" mass="19243" checksum="1093B221471FAFC6" modified="2016-09-07" version="1">MPPKRKSTTDDDDDEYRRKRDRNNQVKWPHNCIIRERGVLSQKSFTIYYNCARSLPKTQAVKRSRVKSKMKTEETQQRVNDLRLKNQLLEDKIDNQKKELKFLKELFITQAQAKADKLDGFNLNELLKDDDGDDEEEDEGQSSSKKRAKEQTYGEGSKSRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3I8</accession>
    <name>A0A182P3I8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3I8"/>
    <dbReference type="STRING" id="199890.A0A182P3I8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001473-RA">
        <property type="protein sequence ID" value="AEPI001473-PA"/>
        <property type="gene ID" value="AEPI001473"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001473"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001473-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="455" mass="52529" checksum="A0578540A09F8619" modified="2016-09-07" version="1">MVSHGCGYFSECSVEQAQSIADRRIRLADELLQKYERERTLYSDKLEVPLGSEAFADGAREIIEEYDEEAEKRWREEHRQRVRESKQNEAKERAAKKNAPAEEMSDKELFAKLEEMELLEELENEMDQLELPAGEDGDDEDDQLGRLMRGEIRLNERKRVAHIQTNDSSERVSIANFQSIEQHKENDQNTVQEEEVEEEIETTDDEEDVENEEEDDDISTEFSQLLLETKNYSQKDKIKVFQVKLKDVRQRLYQNSIDLVQKVDLYQLHDELEEALDFMLPSNESVEDQSAEKPLPLPLSGTPASKKIQFAEEDQIKLIRNRHQDHNNDEQGTKNDESNNTLFIPIKHSVKYYTAYPSDEIQSPADIYRSFLEESLKHSPTVELKSILKAPKTTDNGNTIQGPSVAKQPTCRPGKKPPSPVPDVIGEVVEHTVAMSDVKPPEQKKKVSRFKLQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3U4</accession>
    <name>A0A182P3U4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3U4"/>
    <dbReference type="STRING" id="199890.A0A182P3U4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001580-RA">
        <property type="protein sequence ID" value="AEPI001580-PA"/>
        <property type="gene ID" value="AEPI001580"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001580"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF2">
        <property type="entry name" value="IP09356P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001580-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="229" mass="26270" checksum="D14DA3567B4A273B" modified="2016-09-07" version="1">MPSADGAISETVCGRAGQLLGNCFRNFTPTVAIEAMHAVKIPDSLEEINKRCLIFNRGMECVRQYLKQCVNARQRKIIENEVYGAQKLYEFLCYDPVFQREFLRHKNCFQVVHLEWDHCSNQFTGMLKDEMARITKQSINVQYVNFCCARYAYENCVYNSARFICKPDSALFLRRIAKLLSTDKHFLNCDSIEGELCSGGPVSRMVQNSWVCYATVVPLLLMVVSVVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P427</accession>
    <name>A0A182P427_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P427"/>
    <dbReference type="STRING" id="199890.A0A182P427"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001663-RA">
        <property type="protein sequence ID" value="AEPI001663-PA"/>
        <property type="gene ID" value="AEPI001663"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001663"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051384">
        <property type="entry name" value="Mth_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130866" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="199"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001663-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="495" mass="55963" checksum="569BFCFC5FD0101D" modified="2016-09-07" version="1">MSATTANARATLTLTLLCAIFGTTRSTTTSPVRINKCCEKFEVMYDGKCTVASTVNATVWKPEFIGRKGERNVQVDNYRFVIGLPDCGTKQKFNIYEYHDSYDKLILFPDGQLRHLILRHHSSGPGGSNVGNYLDEDYFDTGDGNGPLLQYDYTQGLYCMDRAIGSGDGDGSELMEGLIAKVCSPKEEIHWTDSDVMLRKIINPICHGLAMIILLVVAIIYFVLPTLRDLVGNMVTTITMCLIVSQAADLVRIFTELSNHVSFLVADLFFYVSLLGAFFWLNAMGYYIWKMFRTRNVFLRVSDGRKYCWYSGYAWGCTGTMAAIAVFAHFFLDLPDSTGGRTGGSAGTETQHIGRESFFEGQDNISWMGIAVFFTPIAFIIIVNIFFFVTTLRFINRMHTYGRIHHKLRCSFVMFTLIFVTMSVAWLFLILSWLHFDGLLYMHIIANALQAPAILYICVLRQKHVTFLVKSCFRDQAPQATEWGDEMTYMNGGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4R0</accession>
    <name>A0A182P4R0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein decapentaplegic</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4R0"/>
    <dbReference type="STRING" id="199890.A0A182P4R0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001896-RA">
        <property type="protein sequence ID" value="AEPI001896-PA"/>
        <property type="gene ID" value="AEPI001896"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001896"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051094">
        <property type="term" value="P:positive regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13760">
        <property type="entry name" value="TGF_beta_BMP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000103">
        <property type="entry name" value="Bone morphogenetic protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.970:FF:000018">
        <property type="entry name" value="Decapentaplegic, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF263">
        <property type="entry name" value="PROTEIN DECAPENTAPLEGIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0339">Growth factor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130892" description="Protein decapentaplegic" evidence="13">
        <location>
            <begin position="24"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="14">
        <location>
            <begin position="389"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001896-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="507" mass="57062" checksum="6001122C327B7DF3" modified="2016-09-07" version="1">MYAWVYVFAVMAISHGALRVASTDSTSSSRTEATAVLLSVDPDQSYYNQPATKDTVQSTPSVTDVSPEPRIGGSGDTHEYEEYVAGNGAVQLVEEVAEEEEPELENEFSDEEEQQQTVDVDDGDSGASRPDPKTLVEIEKNLLSLFGFPNRPKIDRSKVVIPVAMKQLYAQIMGHDLVDSVSVPKEGLNTRNANTVRSFTHEESHIDERFQHHHRFRLLFNVSSIPRGEKLRAAELTLTREGIPHRSNRAQARTPVLYQVMVYDIVRPGVKGKRPPTFLLVDTKTLAINESGTASFDVMPAVERWLRQPRKNHGLFVQVTGRGRSPQSHSRQRRSALSVAPVHEHVRLRRSAAERHDSWVQKQPLLFTYTDDGRHKQRPIRDAISSANRARRASAKRSSRRKNELCQRKPLYVDFSDVGWNDWIVAPPGYEAYFCQGDCRFPIADHLNTTNHAIVQTLVNSYNPTLAPKACCVPTQLSSISMLYLNEQNKVVLKNYQDMTVVGCGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P563</accession>
    <name>A0A182P563_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P563"/>
    <dbReference type="STRING" id="199890.A0A182P563"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002051-RA">
        <property type="protein sequence ID" value="AEPI002051-PA"/>
        <property type="gene ID" value="AEPI002051"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002051"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009838">
        <property type="term" value="P:abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19817">
        <property type="entry name" value="Bbox1_ANCHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044553">
        <property type="entry name" value="Bbox1_ANCHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002051-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="326" mass="36470" checksum="B624B89EEC95E299" modified="2016-09-07" version="1">MACTICTRSFGFFNKEHGCPVCKFSFCSGCLKYKLVRDGKKLNVCLRCSKLAAIEDSSKLQAQDGPRYQEPTSSKVTAEPVRQIPKDPPPESEKSEDDVIRSKLEALKATDLGDQLPVTEEEDSSKAGVDNVDIEKRLAALKGVEYKEYKDASQRFMAPDNRTEEKKVQDLLGQFLEETKLINVMEGKRLEQDEEIANRLKALKEFPTGGGPVHASSKAPTLPDSDSDEGLTDEELARKLAQRYAEEGKLEAKLHPESDDEDDGTKTATSNDVEEQLPWCTICNEDAALRCRGCDNDLYCRACYKEFHYDEDPQEHRTVPFKGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5A8</accession>
    <name>A0A182P5A8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5A8"/>
    <dbReference type="STRING" id="199890.A0A182P5A8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002096-RA">
        <property type="protein sequence ID" value="AEPI002096-PA"/>
        <property type="gene ID" value="AEPI002096"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002096"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000085">
        <property type="entry name" value="SIX homeobox 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF44">
        <property type="entry name" value="SIX HOMEOBOX 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="322"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="324"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002096-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="420" mass="46309" checksum="E0530B892807EEC8" modified="2016-09-07" version="1">MDTSGLSPLADLDSSSGGSDGVGGFNHGQTIYMAQGVYRDNPNPIKTLFFSEKLQEFTDKDSNHHQHHQERKFHETGYNQIKAGPQGQVHHTGDIIYYASKPLSEASPGGVLVNGAGVTNGSTGTSNGGNLLANGSVIPNGLSSCGALGARTDNNNSSYLQSLQPPPSGPVQPSATAASTGHPLASSNGAGDLERKCFSFSPEQIQCMCEALQQEGDLEKLATFLWSLSPSDLISGNESLLRARALVAYHRGLYHELYAVLESHFFSPKYHADLQALWFKAHYREAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKEKSRNALKDCYTRNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDRTPQSSRPDLMMSVLPVTPDQMDGSYQRLFNVANYGPAHGYHANDMYAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5C7</accession>
    <name>A0A182P5C7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P5C7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002117-RA">
        <property type="protein sequence ID" value="AEPI002117-PA"/>
        <property type="gene ID" value="AEPI002117"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002117"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000483">
        <property type="entry name" value="Zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="15"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
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            <end position="742"/>
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    </feature>
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        <location>
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            <end position="767"/>
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    <feature type="domain" description="C2H2-type" evidence="7">
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            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
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            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
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            <begin position="1419"/>
            <end position="1447"/>
        </location>
    </feature>
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        <location>
            <begin position="1450"/>
            <end position="1477"/>
        </location>
    </feature>
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            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="820"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="359"/>
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        </location>
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        <location>
            <begin position="1666"/>
            <end position="1685"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002117-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1685" mass="181759" checksum="3C9F53BD7ED30971" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5D7</accession>
    <name>A0A182P5D7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-catulin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5D7"/>
    <dbReference type="STRING" id="199890.A0A182P5D7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002127-RA">
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        <property type="gene ID" value="AEPI002127"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002127"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
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        <property type="entry name" value="CTNNAL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342:SF1">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002127-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18992" checksum="155AF7C73FE0E723" modified="2016-09-07" version="1">MIRFVPELGSRRRRGSKIVWKFVKDEARCGSNGFRKGVLQRWLFKFVERLGYGASGRSKRWSNGAGKKRAATFDRATTVRVGKVSRQNSTISTLVQHRSEQQHHTSEQKMRAIGRVGQAVNLAVERFVTVGETIADDNPEIKQDMYDACKEARAAVIRRCDRGHIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5G7</accession>
    <name>A0A182P5G7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182P5G7"/>
    <dbReference type="STRING" id="199890.A0A182P5G7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002157-RA">
        <property type="protein sequence ID" value="AEPI002157-PA"/>
        <property type="gene ID" value="AEPI002157"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002157"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000189">
        <property type="entry name" value="Ubiquitinyl hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF19">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="9">
        <location>
            <begin position="56"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="252"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002157-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="657" mass="71998" checksum="34DF6BDEBA9881C4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5P3</accession>
    <name>A0A182P5P3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P5P3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002234-RA">
        <property type="protein sequence ID" value="AEPI002234-PA"/>
        <property type="gene ID" value="AEPI002234"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002234"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF36">
        <property type="entry name" value="APOLIPOPHORINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130995" description="Vitellogenin domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="3323"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="5">
        <location>
            <begin position="34"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="6">
        <location>
            <begin position="2747"/>
            <end position="2911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002234-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3323" mass="366169" checksum="AF1CBD891C51CD17" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P687</accession>
    <name>A0A182P687_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RB1-inducible coiled-coil protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">FAK family kinase-interacting protein of 200 kDa</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P687"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002435-RA">
        <property type="protein sequence ID" value="AEPI002435-PA"/>
        <property type="gene ID" value="AEPI002435"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002435"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000049">
        <property type="entry name" value="RB1-inducible coiled-coil protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="19">
        <location>
            <begin position="1236"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="596"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1412"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1486"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1547"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1006"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1101"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1172"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1412"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1486"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1547"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1570"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053494"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069790"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00080154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002435-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1627" mass="181142" checksum="FEBDD14211623703" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6Z4</accession>
    <name>A0A182P6Z4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6Z4"/>
    <dbReference type="STRING" id="199890.A0A182P6Z4"/>
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        <property type="protein sequence ID" value="AEPI002694-PA"/>
        <property type="gene ID" value="AEPI002694"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002694"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030297">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GM20388"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21105">
        <property type="entry name" value="GH16255P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21105:SF0">
        <property type="entry name" value="GH16255P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002694-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="75" mass="8568" checksum="9362FC5172E2F5C0" modified="2016-09-07" version="1">MAECPPAMDGMERFACPTPDRQGRYRCIDDHVLCDGFVDCPEGEDEDRQACMFYKTTKAHLDVLADALLRWARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P703</accession>
    <name>A0A182P703_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BCCIP homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P703"/>
    <dbReference type="STRING" id="199890.A0A182P703"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002703-RA">
        <property type="protein sequence ID" value="AEPI002703-PA"/>
        <property type="gene ID" value="AEPI002703"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002703"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002703-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="301" mass="33817" checksum="043EEEBBAB7B8BDE" modified="2016-09-07" version="1">MTSKKLKVEADDDEEHRMDAKSGSDESSDEENDEAYEGDEGITVDFEGRNPIDPDLDGIKQLLGQLFVKAHIDLTELAGVIVAQNYVGSVLKQAYNDGDDDEEDEDTDMGDPCQVVFGVTTVINLANKQELSSVRQLKKMVFEKAEKYATELVMQKFRDALEDGSKTTGLLLNERFINIPAAVCVPMCENLLTEMERARSKNMPFTFDYYLMFVKYYQQAASGDKPAEVIYSNDEEEYFIKDACASFNYSVQKETTTALAGQWQKKDEELQPFRKVLLIEASKLPGIVATIKNLISSVTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P733</accession>
    <name>A0A182P733_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P733"/>
    <dbReference type="STRING" id="199890.A0A182P733"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002735-RA">
        <property type="protein sequence ID" value="AEPI002735-PA"/>
        <property type="gene ID" value="AEPI002735"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002735"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002735-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="513" mass="53286" checksum="9B733C2B604A4228" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P823</accession>
    <name>A0A182P823_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P823"/>
    <dbReference type="STRING" id="199890.A0A182P823"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003076-RA">
        <property type="protein sequence ID" value="AEPI003076-PA"/>
        <property type="gene ID" value="AEPI003076"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003076"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131077" evidence="7">
        <location>
            <begin position="29"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003076-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="556" mass="62111" checksum="9E4A6DC1ECD4AAC5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P853</accession>
    <name>A0A182P853_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P853"/>
    <dbReference type="STRING" id="199890.A0A182P853"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003106-RA">
        <property type="protein sequence ID" value="AEPI003106-PA"/>
        <property type="gene ID" value="AEPI003106"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003106"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003106-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="189" mass="22178" checksum="D45DE09ED20F7C32" modified="2016-09-07" version="1">MPVTWLGHTYVIHHCNGQCLIVLNTKVNERHPLQELYAKNIPRNFGPDELVPIFSNAGLVHTIRLLMDYGQENRGYAYVSYVNPSHNGRALRVLNGMPLNETQRLELYRSRDRRRFQLCNVHHLCTVPMMHRTIAHMTHITDFEYQIIPRELAYDVELNFKSHNDYIHAFNKLNRVKNMFGPSCFVKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8A3</accession>
    <name>A0A182P8A3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8A3"/>
    <dbReference type="STRING" id="199890.A0A182P8A3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003156-RA">
        <property type="protein sequence ID" value="AEPI003156-PA"/>
        <property type="gene ID" value="AEPI003156"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003156"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="381"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003156-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="706" mass="80283" checksum="04B2BC076C382FCD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8G2</accession>
    <name>A0A182P8G2_9DIPT</name>
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        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit theta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-theta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. Required for correct subcellular localization of pgl-1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterooligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8G2"/>
    <dbReference type="STRING" id="199890.A0A182P8G2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003215-RA">
        <property type="protein sequence ID" value="AEPI003215-PA"/>
        <property type="gene ID" value="AEPI003215"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003215"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003215-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="546" mass="59381" checksum="6FC82C9E9B4049F2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8P8</accession>
    <name>A0A182P8P8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8P8"/>
    <dbReference type="STRING" id="199890.A0A182P8P8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003302-RA">
        <property type="protein sequence ID" value="AEPI003302-PA"/>
        <property type="gene ID" value="AEPI003302"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003302"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF76">
        <property type="entry name" value="NEUROPEPTIDE SIFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003302-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="682" mass="74627" checksum="56886E7F592108B1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8V5</accession>
    <name>A0A182P8V5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cell surface proteoglycan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glypican family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8V5"/>
    <dbReference type="STRING" id="199890.A0A182P8V5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003359-RA">
        <property type="protein sequence ID" value="AEPI003359-PA"/>
        <property type="gene ID" value="AEPI003359"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003359"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905475">
        <property type="term" value="P:regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001863">
        <property type="entry name" value="Glypican"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822:SF29">
        <property type="entry name" value="DIVISION ABNORMALLY DELAYED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01153">
        <property type="entry name" value="Glypican"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 12" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003359-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="199" mass="21969" checksum="AA9D0DC999934A9F" modified="2016-09-07" version="1">MHPWDDLLDVREGHCRGRGGTVANLEVVEQACGVPSMMPSEYLADGSYEEAPQTQGSGSKWPLSPDNEMLQFQMTIDKNKDLFIQLSTTLCEDEDYHPTDEDCWTGSSLSDYTQQVVTTIGDRYNPEVVYNASATVSPHMQTLVDRLINLKTSVNKAYSTNKFRSDIDKMQSDMAEGSGDSYPSDDDEDGDLASGSGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P944</accession>
    <name>A0A182P944_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003448-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="187" mass="18949" checksum="149DD20935BDE2DD" modified="2016-09-07" version="1">MVRRAVSTSPESTNHHHLNSHHHLSQAQTPTSSTSSLSSASDGQPVSQQPSPSSQQHSPISVSSASGGGGAGGGSVANAGAATGGGHGYDVLQLPGYVRQLPGTLPGQQHVHLTAAPPHGENGGHGGPAGGGIAFIATGPYGGEYYPDHSYYYPHPDYGSPPPPAGHICPVHHPDYGKGTKKKDHVC</sequence>
</entry>
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            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
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            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="gene ID" value="AEPI003518"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
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        <source>
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            <dbReference type="PROSITE" id="PS50157"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003518-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1325" mass="142515" checksum="81EFBA9ED8214E79" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
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    <name>A0A182P9I5_9DIPT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003590-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9X6</accession>
    <name>A0A182P9X6_9DIPT</name>
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        <recommendedName>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182P9X6"/>
    <dbReference type="STRING" id="199890.A0A182P9X6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003730-RA">
        <property type="protein sequence ID" value="AEPI003730-PA"/>
        <property type="gene ID" value="AEPI003730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003730"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003730-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="250" mass="28690" checksum="A281F31303DBF354" modified="2016-09-07" version="1">MEQFNYSALHLHAVLAEGCFGSPDYAYKAVLKEHTILSQLSHPRIVQYLGYFQTTSSWNIVLEFAERGNLASFLDRRSAEGAFLNQHTVMAKFSDIADGLVYLHQRNVIHRDLKPANVLICVDNRLKLADFGISKIMHENDLNRTIVGTPLYMAPEVARGKDYDYKSDVWALGIIFYELCMLQHPFVDGLLKGRKQKFSVPQIDCQRLGYSTALQLLCDMMIQKDLTKRWTLENILTQFHVLVLMNRTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA16</accession>
    <name>A0A182PA16_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PA16"/>
    <dbReference type="STRING" id="199890.A0A182PA16"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003770-RA">
        <property type="protein sequence ID" value="AEPI003770-PA"/>
        <property type="gene ID" value="AEPI003770"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003770"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19813">
        <property type="entry name" value="Bbox1_BRAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19798">
        <property type="entry name" value="Bbox2_BRAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14959">
        <property type="entry name" value="NHL_brat_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="201"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="282"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="342"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="819"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="866"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003770-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1069" mass="113787" checksum="02D170E9A176C436" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAF5</accession>
    <name>A0A182PAF5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAF5"/>
    <dbReference type="STRING" id="199890.A0A182PAF5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003909-RA">
        <property type="protein sequence ID" value="AEPI003909-PA"/>
        <property type="gene ID" value="AEPI003909"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003909"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003909-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="127" mass="14138" checksum="D3AA3DE81BA31DA6" modified="2016-09-07" version="1">MALLSAMKGKLISVIGDEDTCVGFLLGGVGEINKNRHPNFMVVDKNTAVSEIEDCFKRFIKRDDIDIILINQNYAELIRHVIDSHTAPTPAVLEIPSKDHPYDASKDSILRRAKGMFNPDDMIANRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAL8</accession>
    <name>A0A182PAL8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA ligase</fullName>
            <ecNumber evidence="15">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A182PAL8"/>
    <dbReference type="STRING" id="199890.A0A182PAL8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003973-RA">
        <property type="protein sequence ID" value="AEPI003973-PA"/>
        <property type="gene ID" value="AEPI003973"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003973"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="18">
        <location>
            <begin position="573"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003973-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="845" mass="94312" checksum="C6D2BD3A36F0FAA2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB14</accession>
    <name>A0A182PB14_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein rolling stone</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PB14"/>
    <dbReference type="STRING" id="199890.A0A182PB14"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004119-RA">
        <property type="protein sequence ID" value="AEPI004119-PA"/>
        <property type="gene ID" value="AEPI004119"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004119"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049352">
        <property type="entry name" value="Rost"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF46">
        <property type="entry name" value="IP08657P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21534">
        <property type="entry name" value="Rost"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004119-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21194" checksum="0CDDB2E9E3060F43" modified="2016-09-07" version="1">MPNVFKIYWMLHNITLILSVCITIIYWAILHNETMPVDPNNILIHACNCVFMFLDLIIVAYPVRIWHVLQPIAFGLVYCIFSVIYYAADGTDRFGRPYIYNVLDWNEPGKAMVTVVGTILLAMIVHMLMFAIYKLRVKVYLRYFNHKPIIPTNSTLQLQTGKCDGISMVYGNDNKAFSISERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBM3</accession>
    <name>A0A182PBM3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBM3"/>
    <dbReference type="STRING" id="199890.A0A182PBM3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004328-RA">
        <property type="protein sequence ID" value="AEPI004328-PA"/>
        <property type="gene ID" value="AEPI004328"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004328"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000054">
        <property type="entry name" value="Dual specificity phosphatase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004328-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="176" mass="19836" checksum="F610151443F049D9" modified="2016-09-07" version="1">MPDHDIEMITSEQLHAALRKSQKHFIILDCRSSHEYTESHIRTAVNFSIPSIMLRRFAAGKIDITSTIKCRDLKERILSCYKESTFVLYNNSNEPVGDGGAAREDLVLITGCSGLVSVGGTATAAGNDTTINVLHRKLKQDGCRVVCLEGKFYHFYCYYFINYCLGLYCLAKNVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBN0</accession>
    <name>A0A182PBN0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PBN0"/>
    <dbReference type="STRING" id="199890.A0A182PBN0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004335-RA">
        <property type="protein sequence ID" value="AEPI004335-PA"/>
        <property type="gene ID" value="AEPI004335"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004335"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04309">
        <property type="entry name" value="HAD_PSP_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.210:FF:000002">
        <property type="entry name" value="Phosphoserine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000158">
        <property type="entry name" value="Phosphoserine phosphatase SerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.210">
        <property type="entry name" value="Phosphoserine phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004335-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="323" mass="34807" checksum="43BFD97BD41A9932" modified="2016-09-07" version="1">MLIKRIDVLYFSALFGSLVAISATDSSRGVSSLAGAGESLEPALAGRRNSLPPASPIFKPIVPSKVNGLASRNGTQLHHHTQNGNGMTNDRPVELSKRTVEAKEALKKAQIVCFDVDSTIITEEGIDELAQFCGKGSEVAALTKEAMGGSMTFQEALKRRLDIIKPSQRQIREFLKTHPSIISAGVKELIEQLRKNNAEIFLISGGFDCLIEPVADALEIPLCNLYANRLFFNYNGSYAGFDTAQPTSRSGGKAEAIKMIRNVMAGGVGTGADKVVAMIGDGMTDLEACPPANMFIGYGGNAVREEVQKRATYYVTNFADLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBW2</accession>
    <name>A0A182PBW2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBW2"/>
    <dbReference type="STRING" id="199890.A0A182PBW2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004418-RA">
        <property type="protein sequence ID" value="AEPI004418-PA"/>
        <property type="gene ID" value="AEPI004418"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004418"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000087">
        <property type="entry name" value="Counting factor associated protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031305">
        <property type="entry name" value="Casein_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00306">
        <property type="entry name" value="CASEIN_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018657088" evidence="8">
        <location>
            <begin position="18"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="10">
        <location>
            <begin position="244"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="329"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004418-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="547" mass="62242" checksum="C5194E87D61F0BAE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCA4</accession>
    <name>A0A182PCA4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCA4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004559-RA">
        <property type="protein sequence ID" value="AEPI004559-PA"/>
        <property type="gene ID" value="AEPI004559"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004559"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004559-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="354" mass="38316" checksum="0C7B71F587AB8551" modified="2016-09-07" version="1">QQEKRRELRLKRFWRTTTKPPTSSEESGGCESPTKLGRKAFQQPSASSSSDSPPKHPTCSLPLLQVWPSQDSPRGEADGQSFVFPIVADDQQQSSNGRRNSLFVDQLQAGDSGIDSVQASPSPIAMPCHPLVVSNAISPSASPTAGSPTPSVDRATRRPSTSLLHPDHARIFALRAPTSPDQTSLEDSTEFNGATTSNHLCTASSSTTSSLTSVAVATLGHHPQRSSDPWLRPERDKDNPELDQRRASTMTARLSLFDALDLEYALLRAAARGSVGPYSLSESLHKLTFTQSLAFPALARGLATKRRNSTEQSSSRPLNPNESGLNTFAKVVTACVLVMVSFLVFLVVYKYVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCE7</accession>
    <name>A0A182PCE7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">BIG2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP210 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PCE7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004602-RA">
        <property type="protein sequence ID" value="AEPI004602-PA"/>
        <property type="gene ID" value="AEPI004602"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004602"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058779">
        <property type="entry name" value="Ig_NUP210_13th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057586">
        <property type="entry name" value="Ig_NUP210_16th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055096">
        <property type="entry name" value="Ig_NUP210_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055097">
        <property type="entry name" value="Ig_NUP210_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055098">
        <property type="entry name" value="Ig_NUP210_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055099">
        <property type="entry name" value="Ig_NUP210_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056899">
        <property type="entry name" value="Ig_NUP210_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26181">
        <property type="entry name" value="Ig_NUP210_13th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25354">
        <property type="entry name" value="Ig_NUP210_16th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22967">
        <property type="entry name" value="Ig_NUP210_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22969">
        <property type="entry name" value="Ig_NUP210_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22963">
        <property type="entry name" value="Ig_NUP210_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26182">
        <property type="entry name" value="Ig_NUP210_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22962">
        <property type="entry name" value="Ig_NUP210_7th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24902">
        <property type="entry name" value="Ig_NUP210_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131201" description="BIG2 domain-containing protein" evidence="11">
        <location>
            <begin position="26"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1811"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="14">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="15">
        <location>
            <begin position="125"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="13">
        <location>
            <begin position="250"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="12">
        <location>
            <begin position="641"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="16">
        <location>
            <begin position="917"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="18">
        <location>
            <begin position="1183"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="17">
        <location>
            <begin position="1490"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1868"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1899"/>
            <end position="1912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF26181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004602-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1933" mass="213174" checksum="1B80664F82CDCDC8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCF8</accession>
    <name>A0A182PCF8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">trypsin</fullName>
            <ecNumber evidence="12">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A182PCF8"/>
    <dbReference type="STRING" id="199890.A0A182PCF8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004613-RA">
        <property type="protein sequence ID" value="AEPI004613-PA"/>
        <property type="gene ID" value="AEPI004613"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004613"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF97">
        <property type="entry name" value="GH13245P2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0222">Digestion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131095" description="trypsin" evidence="14">
        <location>
            <begin position="18"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="41"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004613-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="281" mass="30332" checksum="FF39A4E347B3B6AD" modified="2016-09-07" version="1">MKVCVTTLYAMTALTSCTTLMSSAASRRSASSYDRTNEERIVGGVPVDIRDYPYQVSLRRGRHFCGGSIINSQWILTAAHCTRTIIASNLWVHAGSSHVNDGGESIKVRQIHHHPKQNSWSDYDFSLLHLDQPLNFSDSVQAIPLRKPSASGEQLADGTLCKVSGWGNTHNPDESALVLRAASVPLTNHRRCSEVYEGIGSVTESMICAGYDEGGKDSCQGDSGGPLVCDGQLTGVVSWGKGCAEPGYPGVYAKVSTAYEWIEQTLHPALASAERPNVEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDN3</accession>
    <name>A0A182PDN3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Decapping nuclease</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PDN3"/>
    <dbReference type="STRING" id="199890.A0A182PDN3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005038-RA">
        <property type="protein sequence ID" value="AEPI005038-PA"/>
        <property type="gene ID" value="AEPI005038"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005038"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="4">
        <location>
            <begin position="26"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005038-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="385" mass="45553" checksum="AB930BBD056A4D97" modified="2016-09-07" version="1">MFTETTIDPDHRQPARQSKPFPTVTKPTLVGFFSLNQNRQYDASAAQLKYLSLPRSPRTELRLDLNEGFEIHQPKPVSAKEEKIGALLTFIRQTDPRELWVAHENGQLRLKYSFVCFRGLLRLIACTPYDWKTGWIVQAVRYRDTIYLCERPTPEKEALARNETEQQKRFCFYGFKFEQHILTEEPSCVKPDTSAPVLLGEEFCCMFNTTLAGHRLLYGAEMDGIVANRPFDRERLRVEELRRQEFVEVKVKRRETTQRQVDNFYRFKTKNWWCQSFLVNVQRLVVGLRDDAGIVREITEMSLDEIRRESRPYWSPAVCMNFCGDFLAEVVRVMGRTDSCRKVYQFEYDSRECKRVRYRVLEEEADFLPDWYTKFVEELQSNCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDV7</accession>
    <name>A0A182PDV7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">threonine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIGX family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182PDV7"/>
    <dbReference type="STRING" id="199890.A0A182PDV7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005112-RA">
        <property type="protein sequence ID" value="AEPI005112-PA"/>
        <property type="gene ID" value="AEPI005112"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005112"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="24">
        <location>
            <begin position="123"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="23">
        <location>
            <begin position="391"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005112-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="995" mass="114127" checksum="E78D769C5907954D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDY5</accession>
    <name>A0A182PDY5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA-dihydrouridine synthase 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDY5"/>
    <dbReference type="STRING" id="199890.A0A182PDY5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005140-RA">
        <property type="protein sequence ID" value="AEPI005140-PA"/>
        <property type="gene ID" value="AEPI005140"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005140"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102266">
        <property type="term" value="F:tRNA-dihydrouridine20a synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102267">
        <property type="term" value="F:tRNA-dihydrouridine20b synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000159">
        <property type="entry name" value="tRNA-dihydrouridine synthase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="12">
        <location>
            <begin position="61"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="349"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005140-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="432" mass="48681" checksum="5DE2C11ABC706B99" modified="2016-09-07" version="1">MKEKTNIRHLFSSAAERNTFLKICAPMVRYSKYESVSLLEPFRAKRLVSMPRLILLFHCSRLEFRNLVRSYGTDLAFTSMIMADSFCQSEKARLNEFTTNEDDTPLIAQFAANNTIDFLSASEMVYPYVDGVDLNCGCPQRWAMAEGYGSALLKTPELIADMLGTVRRNMPSTFSVSVKVRLLSSSDQKHTIDMCRQLEATGITFLTVHGRTAPEMTKVPVHKDALQEIKQSIAIPMVANGDIFTLADAEQMYSQTKCDGVMAARGILSNPALFAGYRSTPVECVKRWMDICQQADTDITYQCMHHHFSFMTESLLAKRLRYELNSLPKEKHKVYEFIRTHLPLDGVVDEGNGGKQYPEKTSCTYSEQKYRERTATRSKNSRAADGYDPEASEGNFFQSKRVELDETAAAQNGEDSVDGVDFMDGGSLLFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE65</accession>
    <name>A0A182PE65_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the jagunal family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PE65"/>
    <dbReference type="STRING" id="199890.A0A182PE65"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005220-RA">
        <property type="protein sequence ID" value="AEPI005220-PA"/>
        <property type="gene ID" value="AEPI005220"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005220"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009787">
        <property type="entry name" value="Jagunal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07086">
        <property type="entry name" value="Jagunal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1989" evidence="8">
        <location>
            <begin position="44"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005220-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="455" mass="52650" checksum="4789177E42254467" modified="2016-09-07" version="1">MKRTFDYHPPTVCYDKPAAAVVSEQDCESRRRRALAGRRVQELIVPKKSARTWTMQAGDLCRVSLPEGSQVGDLNLWNLENPRRERFFSGKTRQIHSTHLKTYDRLWSCFPYLRPMAAFVKDTLEDYGVDRDGGSLHDVVGTRCDDYIYKLITGEDRFGSCHSYLTEAVKEHGLDEVDVHDTWNIFMCTGFTRDTQQYFCKPSPARKGDYIEFLAEMNLLVALSACPQGDVSIQVGQKVPDEKCFPMKVELPPSREQTMASRGGPMVLGTDGTDFEHRQRVAAHYQISALNKSRLKYCIFFHYLLFFVMLVKLSADILDRLDIFILEIEELQIPPPLWWEYFWCLSVFLSFIGLASIRGNRVNDMKKYMVGISTIGFVPLLYCIFYYLNDVLEYLGLEEGTDLDDTDIFVWQGYPYGLLWYGFVLMAFQVHFFSLFFAWNLIKAWRGRSALKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEA6</accession>
    <name>A0A182PEA6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 G2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin carrier protein G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase G2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with AUP1 (via C-terminus); the interaction recruits UBE2G2 to lipid droplets. Interacts with ubiquitin ligases AMFR/gp78 and RNF139/TRC8; recruitment to lipid droplets by AUP1 facilitates interaction of UBE2G2 with AMFR and RNF139, leading to sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PEA6"/>
    <dbReference type="STRING" id="199890.A0A182PEA6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005261-RA">
        <property type="protein sequence ID" value="AEPI005261-PA"/>
        <property type="gene ID" value="AEPI005261"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005261"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005261-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="158" mass="17660" checksum="C2751107A4C2C0E4" modified="2016-09-07" version="1">MAEYRQLTLNPPEGIIAGPISEENFFEWEALITGPEGTCFEGGIFTAKLIFPPDYPLSPPKMKFTCEMFHPNIFTDGRVCISILHAPGDDPLGYELSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDAAIMWRENREEFNKIARRIVRKTLGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEZ0</accession>
    <name>A0A182PEZ0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DAG_kinase_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEZ0"/>
    <dbReference type="STRING" id="199890.A0A182PEZ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005495-RA">
        <property type="protein sequence ID" value="AEPI005495-PA"/>
        <property type="gene ID" value="AEPI005495"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005495"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.110">
        <property type="entry name" value="Diacylglycerol kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029477">
        <property type="entry name" value="DAG_kinase_typeI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038199">
        <property type="entry name" value="DGK_typeI_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14513">
        <property type="entry name" value="DAG_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diacylglycerol kinase type I N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005495-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="117" mass="12690" checksum="178517919C566454" modified="2016-09-07" version="1">MASNIHKWEKLSPSEFQQLQDLASYSTKKLQNVLQEFCSPATPSASRFHPDGGFGAGLCAIAFDYAWVTQIHQAARGSAKDIRKNKGVGVFFSCPGLWVSPPAVSSLRPTTMTKDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF70</accession>
    <name>A0A182PF70_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PF70"/>
    <dbReference type="STRING" id="199890.A0A182PF70"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005575-RA">
        <property type="protein sequence ID" value="AEPI005575-PA"/>
        <property type="gene ID" value="AEPI005575"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005575"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF748">
        <property type="entry name" value="FI23927P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005575-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="330" mass="36686" checksum="01456091A482ED08" modified="2016-09-07" version="1">MPTSYDLLPYEWAEPVPLKTNLQRARELIETLLNLLVFVCESVPFWWDALVARFATPKPKNISGQTALVTGGANGLGQAIAIALAKEGCNVAVVDVDETNARETVAKLRRYNVSAEAYKVDVSDYEAVRQLGRDVERDLGPVDILVNNAGILPTSFSLDMLPSHTKRSMEVNVLSSFWTTQTFVDSMIRRRKGHIVAVSSIAGYIATGWAKSYATTQFALRGFMDALEDDLYLRGQAAHVHTTTVFPFAFNTRRQAIRLLKSSSGLTRLPIYEPALLGETVVKAIKTNQRKVIVPETVKPYQLSIYENLPIKIRQLLTKTMAQGEVKLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFJ5</accession>
    <name>A0A182PFJ5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cytosolic iron-sulfur protein assembly protein Ciao1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ciao1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PFJ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005702-RA">
        <property type="protein sequence ID" value="AEPI005702-PA"/>
        <property type="gene ID" value="AEPI005702"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005702"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000136">
        <property type="entry name" value="Probable cytosolic iron-sulfur protein assembly protein CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="303"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005702-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="341" mass="38530" checksum="355459241B0593F1" modified="2016-09-07" version="1">MGKLELVQTLTGHKGRVWSAAWHPTGKMFASCGEDKTIRVWTEADTDRWVTQTVLTDGHTRTIRDVAWSYCGHYLASASFDTTVAVWNKKSGEFECNATLEGHDNEVKSVTWSRSGSLLATCSRDKSVCIWEIHHAPVQEDEYECVAVLNGHTQDVKKVCWQPREDVLASASYDNTIRMYRQDVADGEWEMLEPLESHTSTVWSIGFDATGKRLASCSEDKTVKVWQQYRPDNTLGIVCLERGTVWKCVCTLAGYHTRSVYDIDWCKQTGLLVTACGDDMVRIFREGRDSDPNEPKFELVVAVPAHSRDTNKVAWHPTIPGVLLTASDDSEIKVWKYVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHD2</accession>
    <name>A0A182PHD2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="2 9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2 9"/>
    <dbReference type="AlphaFoldDB" id="A0A182PHD2"/>
    <dbReference type="STRING" id="199890.A0A182PHD2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006341-RA">
        <property type="protein sequence ID" value="AEPI006341-PA"/>
        <property type="gene ID" value="AEPI006341"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006341"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000084">
        <property type="entry name" value="AGAP005119-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000040">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000007">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000026">
        <property type="entry name" value="SD01014p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="12">
        <location>
            <begin position="141"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="557"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="707"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006341-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="847" mass="96011" checksum="9A56D9B52EDD7613" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHJ7</accession>
    <name>A0A182PHJ7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM13A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHJ7"/>
    <dbReference type="STRING" id="199890.A0A182PHJ7"/>
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        <property type="protein sequence ID" value="AEPI006406-PA"/>
        <property type="gene ID" value="AEPI006406"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006406"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039102">
        <property type="entry name" value="FAM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059029">
        <property type="entry name" value="FAM13A_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904">
        <property type="entry name" value="FAM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904:SF17">
        <property type="entry name" value="RHO-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26116">
        <property type="entry name" value="FAM13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM13A-like" evidence="4">
        <location>
            <begin position="829"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="760"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="835"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="760"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="806"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006406-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="899" mass="100080" checksum="622C5A8F724EF4D9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHN0</accession>
    <name>A0A182PHN0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182PHN0"/>
    <dbReference type="STRING" id="199890.A0A182PHN0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006439-RA">
        <property type="protein sequence ID" value="AEPI006439-PA"/>
        <property type="gene ID" value="AEPI006439"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006439"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="127"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="326"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="480"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006439-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="726" mass="76586" checksum="AF82F26FBEABEEDF" modified="2019-01-16" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI42</accession>
    <name>A0A182PI42_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fas-binding factor 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PI42"/>
    <dbReference type="STRING" id="199890.A0A182PI42"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006604-RA">
        <property type="protein sequence ID" value="AEPI006604-PA"/>
        <property type="gene ID" value="AEPI006604"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006604"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097539">
        <property type="term" value="C:ciliary transition fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090162">
        <property type="term" value="P:establishment of epithelial cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033561">
        <property type="entry name" value="FBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049390">
        <property type="entry name" value="FBF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33689">
        <property type="entry name" value="FAS-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33689:SF1">
        <property type="entry name" value="FAS-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21007">
        <property type="entry name" value="FBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fas-binding factor 1 C-terminal" evidence="3">
        <location>
            <begin position="475"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="541"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="698"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006604-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1020" mass="116405" checksum="7878198C266C9DBE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI44</accession>
    <name>A0A182PI44_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FIP-RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PI44"/>
    <dbReference type="STRING" id="199890.A0A182PI44"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006606-RA">
        <property type="protein sequence ID" value="AEPI006606-PA"/>
        <property type="gene ID" value="AEPI006606"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006606"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2440:FF:000003">
        <property type="entry name" value="Nuclear fallout, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037245">
        <property type="entry name" value="FIP-RBD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057316">
        <property type="entry name" value="Rab11-FIP3/4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051977">
        <property type="entry name" value="Rab11-interacting_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726:SF7">
        <property type="entry name" value="NUCLEAR FALLOUT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726">
        <property type="entry name" value="RAB11-FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25450">
        <property type="entry name" value="Rab11-FIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09457">
        <property type="entry name" value="RBD-FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144270">
        <property type="entry name" value="Eferin C-derminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FIP-RBD" evidence="9">
        <location>
            <begin position="468"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="235"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006606-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="532" mass="60179" checksum="3212E5F7D3C786E2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI84</accession>
    <name>A0A182PI84_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PI84"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006646-RA">
        <property type="protein sequence ID" value="AEPI006646-PA"/>
        <property type="gene ID" value="AEPI006646"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006646"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006646-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="200" mass="22582" checksum="27B9245EF813E176" modified="2016-09-07" version="1">MSLDIEDCDEEMQQLIADSVNLADELVTVTATEELHRTRHTMLSDLEADVEQYARTIVNYRESLERLALLEYGILHGLKKVLVVPNDLVDQLDRLEGKLETLDELIRERNIFLPPSVISNETFATIGEQQERLASLVQQLDRIGALIEGNQVRETAMSVASVQRKTGKLLQDIDCILKLNTLQKQIIVGFSSKIFHGTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIL3</accession>
    <name>A0A182PIL3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3105 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIL3"/>
    <dbReference type="STRING" id="199890.A0A182PIL3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006775-RA">
        <property type="protein sequence ID" value="AEPI006775-PA"/>
        <property type="gene ID" value="AEPI006775"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006775"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34179">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34179:SF1">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
        <property type="entry name" value="DUF3105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131355" description="DUF3105 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006775-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31803" checksum="7B0A09C7FD3552D1" modified="2016-09-07" version="1">MLRWLAVALTLLFCVQAAEDWTGPWFPNAPKDVALEAGDAIKPIDTAVPETEHAKEKQSSTRVIMGIENPDCDDAKHGLEIDFDPYNVTHSTIYMCLEPKADYKGDYNMDAVITEHNVPSAYVANHKCMNSSIEYAERIPSYGTHRPLWPRYGEYRYVPPQRWLHNSEHGAVIALYHPCANKQQVDELKRIVKGCLYRHVITPSQLPNKDRPFALVTWHATLEFSVLQRSIVESFIEKYALKGPEQTHRDGQYDHLLVDAAKVVSTEDDSVLCPKKQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIU0</accession>
    <name>A0A182PIU0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIU0"/>
    <dbReference type="STRING" id="199890.A0A182PIU0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006853-RA">
        <property type="protein sequence ID" value="AEPI006853-PA"/>
        <property type="gene ID" value="AEPI006853"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006853"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="4">
        <location>
            <begin position="118"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006853-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="432" mass="48169" checksum="9F88CBE77B199E1E" modified="2016-09-07" version="1">MLSFLYTYLTNLPRWHLVAIVLVGYLIYYLMEVVKRPILAVSNGPFKKYLRKHIPTLENKFWPTFWCVESRAQTVFASIIRSNIMPLVEYKREVLTLKDGGEVALDWLETGCDPESPVIIILPGLTGESQAEYIKCLVTAANRIGIRTVVFTNRGLGGVALKTPRLYCASNCEDLSEVVKHVKRTNPHVRIGATGISMGGLILGNYLARHSDEAKSILTAAKIISVPWDVHKGCASIEQPILNNLLGRHLASSLCRTVSKYDILRGEEFDWDMNQVLQSKTIKQFDSAFTSKHFGYKDVDSYYTDATLHNKLHQIKVPLLCLSAADDPFQPLDAIPIKAAANSSHVAILITARGGHIGFLEGWWPANKDQYMGRLFSQYFSAALFDPDNEFYRTAQLMMEHNLTTSTSVPGSPTNKSSLGAAGAIRKKSIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ09</accession>
    <name>A0A182PJ09_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJ09"/>
    <dbReference type="STRING" id="199890.A0A182PJ09"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006922-RA">
        <property type="protein sequence ID" value="AEPI006922-PA"/>
        <property type="gene ID" value="AEPI006922"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006922"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000001">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006922-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="76" mass="9290" checksum="F29463F980EC4DEA" modified="2016-09-07" version="1">MSVKDIYYSDKYYDDEYEYRHVVLPKDIAKLVPRTHLMTENEWRAIGVQQSRGWVHYMVHQPEPHILLFRRPITKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ72</accession>
    <name>A0A182PJ72_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJ72"/>
    <dbReference type="STRING" id="199890.A0A182PJ72"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006986-RA">
        <property type="protein sequence ID" value="AEPI006986-PA"/>
        <property type="gene ID" value="AEPI006986"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006986"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF14">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006986-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="669" mass="76498" checksum="E200D78A5AE060DB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ99</accession>
    <name>A0A182PJ99_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Preautophagosomal structure membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJ99"/>
    <dbReference type="STRING" id="199890.A0A182PJ99"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007013-RA">
        <property type="protein sequence ID" value="AEPI007013-PA"/>
        <property type="gene ID" value="AEPI007013"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007013"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.190:FF:000001">
        <property type="entry name" value="Autophagy related 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.620:FF:000001">
        <property type="entry name" value="Autophagy related 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="10">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="9">
        <location>
            <begin position="120"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="8">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007013-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="231" mass="26802" checksum="B54972A7CAC7921D" modified="2016-09-07" version="1">MANDREILREIWEGKIPVHFKLSADETDVEPEEYFLLIPRLSYFPLVTDKVRKHFLRFVSNELQDGEMWMDSNGIPLKWHFPIGVLYDLLVGTDGTLPWHVTVHFSKFPDDILIRCPNKEIVEAHFMSSLKEADVLKHRGQVVSAMQKKDHNQLWLGLVNDKFDQFWAVNRRLMEPIPDQDGFKHIPVRCYAEDGTYQQKLVAPSTASGQKRLLQDLLDDFSTPVRKAGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJE8</accession>
    <name>A0A182PJE8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJE8"/>
    <dbReference type="STRING" id="199890.A0A182PJE8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007062-RA">
        <property type="protein sequence ID" value="AEPI007062-PA"/>
        <property type="gene ID" value="AEPI007062"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007062"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000084">
        <property type="entry name" value="mRNA export factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007062-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="361" mass="40274" checksum="C260CAA1339EA2F6" modified="2016-09-07" version="1">MFGTQTLGANPAFGSPTATTTTNPMKDFEVTSPPEDTVSAMEFSPATLQQNFLIAGSWDCSVRCWEVEQSGKTVPKSIKTMGGPVLDVCWADDGSKVFIASTDKQVKCWDLASDQVAQVAQHDAAIKTCHWIKGTNYTCLMTGSWDKTLKFWDTRTPQPMMSIQLPERCYCADVDYPMAVVGTAGRHVLIYSLENKPTQFKQQESPLKYQHRTVSVFRDKKKAPTGYALGSIEGRVAIQYVSPLNPKDNFTFKCHRSNGSTGYQDIYAVNDIAFHPIHGTLATVGSDGTFSFWDKDARTKLKSSDTLDQSITKCCFNSNGQIFAYAVGYDWSKGHEYYNPQKKTYIFLRSCYDELKPRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJJ6</accession>
    <name>A0A182PJJ6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 43</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC43 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJJ6"/>
    <dbReference type="STRING" id="199890.A0A182PJJ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007110-RA">
        <property type="protein sequence ID" value="AEPI007110-PA"/>
        <property type="gene ID" value="AEPI007110"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007110"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037666">
        <property type="entry name" value="CCDC43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058771">
        <property type="entry name" value="PWI_CCDC43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26091">
        <property type="entry name" value="PWI_CCDC43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC43 PWI-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007110-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="205" mass="23538" checksum="AF5A5B4367DCAFA1" modified="2016-09-07" version="1">MAAVDEFNSWLNSKLRASKADVSVFGSYITGILEGDENNEEKVEALEGILGAIIEADLEAFINEILDRWNTCHSKDAAEASKPKLDVEVQLAKLLEGQKLATKVEREYTEEERRIKEQILLQYSQLSESEPDEEDEEGATSSSDPKLVKNTNFADVQALAREKREQAKLESQLKKEKDKQDREKQRQLREEKKEKRKTVKGERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK83</accession>
    <name>A0A182PK83_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PK83"/>
    <dbReference type="STRING" id="199890.A0A182PK83"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007349-RA">
        <property type="protein sequence ID" value="AEPI007349-PA"/>
        <property type="gene ID" value="AEPI007349"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007349"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000946">
        <property type="entry name" value="AGAP011229-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000611">
        <property type="entry name" value="Capricious, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131385" description="LRRCT domain-containing protein" evidence="6">
        <location>
            <begin position="29"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007349-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="71734" checksum="027DA569B366A8F5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK96</accession>
    <name>A0A182PK96_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytosolic Fe-S cluster assembly factor NUBP1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication. Negatively regulates cilium formation and structure.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PK96"/>
    <dbReference type="STRING" id="199890.A0A182PK96"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007362-RA">
        <property type="protein sequence ID" value="AEPI007362-PA"/>
        <property type="gene ID" value="AEPI007362"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007362"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Larimer J."/>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLZ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007966-RA">
        <property type="protein sequence ID" value="AEPI007966-PA"/>
        <property type="gene ID" value="AEPI007966"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007966"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001614">
        <property type="entry name" value="Myelin_PLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683:SF12">
        <property type="entry name" value="M6, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683">
        <property type="entry name" value="MYELIN PROTEOLIPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01275">
        <property type="entry name" value="Myelin_PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007966-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="355" mass="39937" checksum="306CC4A1BACEEEC7" modified="2016-09-07" version="1">QTVSGRLSAATSFTVDAYPDRKKKPISTVPDLPATMTSNRNRTPTGQIRDDFLLETNFDDDGALTRAYNTLPQQQATLQRRSIPYRSNLSVDRYSETTLHGKPPRKGGCCKSCVTRIPYATLIATVMCLIGVGVFCGTMFRGTSLAIIMLDQVFHLRLPWIEAVQIIFVVIGASMAALGLMILFVGFLATGATRYKVYRAWGSRVGGRISCAVFMAISYVLNIAWILILCFLSIVTFVFTVFWNMCANTNVQTHRDCIDLTQFYFMFPEGVKQEDMKICEPAKVKAFCKDGVEKCEIMFILATVSCLLIILSFVHYLMCLAANYAHIRDHEKFQELQEIQNLTEMEYSAASKDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM32</accession>
    <name>A0A182PM32_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182PM32"/>
    <dbReference type="STRING" id="199890.A0A182PM32"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008004-RA">
        <property type="protein sequence ID" value="AEPI008004-PA"/>
        <property type="gene ID" value="AEPI008004"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008004"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF113">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008004-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="289" mass="33886" checksum="96A0BB21B3EB0175" modified="2016-09-07" version="1">MDSNVTETVGESLQQQLDHWYTFLVEDLSDKRTAHLPFLHSPLWPMSVLSLYFLLVFYWIPNYMHDRKPYDLRKLMLSYNVFQVVVCYCLIRQLVRHGWTFRYLYTCELADYSNSKDAVGFLHAAYLNYCVKTAELVETVLFALRKKRSQISFLHVYHHVFTYLLAWIFAKYVGGSMLTYTIIVNSLVHICMYSYYLLAVIPHYVPFSLGRLKRYITALQIIQLVSILVNILFAMRSDCAIPRTHILLYAPYMVVLISMFINFYLKTYSGITKALNVCYTDGGVQKKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMW4</accession>
    <name>A0A182PMW4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lamin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMW4"/>
    <dbReference type="STRING" id="199890.A0A182PMW4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008288-RA">
        <property type="protein sequence ID" value="AEPI008288-PA"/>
        <property type="gene ID" value="AEPI008288"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008288"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF11">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="8">
        <location>
            <begin position="56"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="7">
        <location>
            <begin position="415"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="60"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="289"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008288-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="64873" checksum="B858C4D9041F545B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN06</accession>
    <name>A0A182PN06_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN06"/>
    <dbReference type="STRING" id="199890.A0A182PN06"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008330-RA">
        <property type="protein sequence ID" value="AEPI008330-PA"/>
        <property type="gene ID" value="AEPI008330"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008330"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3 5" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008330-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="815" mass="93755" checksum="7B932D0AA5A3894E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN35</accession>
    <name>A0A182PN35_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine rich immune protein (Coil-less)</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PN35"/>
    <dbReference type="STRING" id="199890.A0A182PN35"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008359-RA">
        <property type="protein sequence ID" value="AEPI008359-PA"/>
        <property type="gene ID" value="AEPI008359"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008359"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008359-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33356" checksum="69269368B5B6DB01" modified="2016-09-07" version="1">MGGTLIVSNSVHCIVGLEFYCFRECCVDNLKSQDDAFTFNHIPNDMRVLRLTKVLIKHIDQPILEKIPPFIHTLKIENSQRLKRVSVPTGLSALKITRTGLRRVDIAANSFLSSLEIYKCDLMKVPQVILNAQMIQHLDISSCKLRALNMAQFCDNSHLESLVFDNNNIRFLVDTSNKRCSLYDSLKLLVLSSNKLTTINMELFNVFIKLNRLQLHINRITSISGRLNHSNLTILSIGENQLQHVDLCDWNVPAMEVVTFTLNYLTMVPKCIGNWTSVKELRLSHNKFTRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN94</accession>
    <name>A0A182PN94_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Diuretic hormone receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for the insect diurectic hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN94"/>
    <dbReference type="STRING" id="199890.A0A182PN94"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008419-RA">
        <property type="protein sequence ID" value="AEPI008419-PA"/>
        <property type="gene ID" value="AEPI008419"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008419"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008036">
        <property type="term" value="F:diuretic hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15263">
        <property type="entry name" value="7tmB1_DH_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000155">
        <property type="entry name" value="diuretic hormone receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002001">
        <property type="entry name" value="GPCR_2_diuretic_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF15">
        <property type="entry name" value="DIURETIC HORMONE 44 RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01127">
        <property type="entry name" value="DIUHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="14">
        <location>
            <begin position="56"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="15">
        <location>
            <begin position="148"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008419-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="432" mass="48781" checksum="05AB9906CD246B3D" modified="2016-09-07" version="1">MMHLMNETMPAAALAVTDAGSGEPFGDGNVTGILAEHPSLVEGLLALAMNASGAERCRLQQQAEELLQDVACPSFFDMVSCWPRTPPGTLAVLPCFAELKGVQYDSSQNATRFCNVDGTWDNYTDYDHCHHLEQPPPLPSFEPEIELPTLIYFVGYSISLAALVLAVAVLVYFKDLRCLRNTIHINLFLTYIMSSSLWILILSLQITVKLEVAGCIFLVTLFHYFSTTNFFWMLVEGLYLYMLVVQTFSGDTLRFRKYAIIGWGGPLIFVGAWAVAKPFFGSVSNLEHPNKLEIECSWMRESHIDWIIQGPSCAVLVINLIFLLRIMWVLITKLRSANTVETRQYRKASKALLVLIPLLGITYLIFIYGPVEGVGSHIFAITRAILLSTQGFVVSLLYCFLNSEVRQTLRHHFYRWRDERNILSGKVNNHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PND1</accession>
    <name>A0A182PND1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dual-specificity kinase</fullName>
            <ecNumber evidence="3">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PND1"/>
    <dbReference type="STRING" id="199890.A0A182PND1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008458-RA">
        <property type="protein sequence ID" value="AEPI008458-PA"/>
        <property type="gene ID" value="AEPI008458"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008458"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14226">
        <property type="entry name" value="PKc_DYRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000117">
        <property type="entry name" value="dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044131">
        <property type="entry name" value="PKc_DYR1A/1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF28">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MINIBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="398"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="545"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="678"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="855"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="435"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="564"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008458-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="895" mass="94203" checksum="6484CD7D9DF15AF8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNQ2</accession>
    <name>A0A182PNQ2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rapamycin-insensitive companion of mTOR</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
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        <property type="protein sequence ID" value="AEPI008579-PA"/>
        <property type="gene ID" value="AEPI008579"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008579"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="94"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="674"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="1085"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1379"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1562"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1684"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1731"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1420"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1430"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1572"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1698"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1742"/>
            <end position="1755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008579-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1812" mass="198771" checksum="E28AC987AAD9092A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPK9</accession>
    <name>A0A182PPK9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-splicing ligase RtcB homolog</fullName>
            <ecNumber evidence="10">6.5.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Catalytic component of the tRNA-splicing ligase complex.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182PPK9"/>
    <dbReference type="STRING" id="199890.A0A182PPK9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008888-RA">
        <property type="protein sequence ID" value="AEPI008888-PA"/>
        <property type="gene ID" value="AEPI008888"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008888"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1860.10:FF:000001">
        <property type="entry name" value="tRNA-splicing ligase RtcB homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03144">
        <property type="entry name" value="RtcB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027513">
        <property type="entry name" value="RtcB_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0819">tRNA processing</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="10 11">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="227"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="354"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="429"/>
            <end position="432"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008888-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="506" mass="55843" checksum="4D08CBE0CFD45101" modified="2016-09-07" version="1">MVVREYNEEMKYIERLSPNSFLIKKGFQSNMNVEGIFYANSRLEKLMFDELRNACRPGMTGGFLPGVKQIANVAALPGIVGRSVGLPDIHSGYGFAIGNMAAFDMSDATSIVSPGGVGFDINCGVRLLRTNLFEKDVQPVKEQLAQSLFDHIPVGVGSKGIIPMNAHDLEEALEMGMDWSLREGYVWAEDKEHCEEYGRMLNADPSKVSLRAKKRGLPQLGTLGAGNHYAEIQVVEEIYDKYAASKMGIEELGQICVMIHSGSRGFGHQVATDALVEMEKAMKRDQIETNDRQLACARINSPEGQNYLKAMSAAANFAWVNRSSMTFLTRQAFAKQFNTTPDDLDMHVIYDVSHNVAKMEEHMVNGRPKQLLVHRKGSTRAFPPHHPLIPVDYQLTGQPVLVGGSMGTCSFVLTGTETGMVETFGSTCHGAGRSLSRAKSRRNLDYKDVLRDLEEKGISIRVASPKLVQEEAPDSYKDVRDVVQTCHDVGISNKAIKLRPIAVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQH6</accession>
    <name>A0A182PQH6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine rich immune protein (Coil-less)</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQH6"/>
    <dbReference type="STRING" id="199890.A0A182PQH6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009207-RA">
        <property type="protein sequence ID" value="AEPI009207-PA"/>
        <property type="gene ID" value="AEPI009207"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009207"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF41">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009207-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20799" checksum="7DE5872AC379804C" modified="2016-09-07" version="1">MTGWNVPFLMELSLQNNNLTRIPIGIEKHPNLTTLLLANNLLSVVDLRRLEGWDILQTIDLAGNRIRNVMITGSGRLTLPGLKRVDLSNNQLARLEFVRWDFPKLSSMALAFNRFQRFPNLWKMFPELGNVIAFQNPLLCEAVRNLQQLISTMRLIVDASGFGTPCTTNATFTLQSGRVICCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR71</accession>
    <name>A0A182PR71_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase subunit b</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PR71"/>
    <dbReference type="STRING" id="199890.A0A182PR71"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009453-RA">
        <property type="protein sequence ID" value="AEPI009453-PA"/>
        <property type="gene ID" value="AEPI009453"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009453"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2210:FF:000003">
        <property type="entry name" value="ATP synthase subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0138">CF(0)</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009453-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="236" mass="27026" checksum="BD3599513B013A2F" modified="2016-09-07" version="1">MLSRAVLLSAAKKPAALVLARGAASQPERPKRPEQGGKVRLGFLPEEWFTFFYNKTGVTGPYVFGAGLMTYLCSKEIYIMEHEYYNGLSLAVMVVFAVKKFGPSLAAYLDKEVDKIEDEWKESRENNIQQLTQAIEDEKKEQWRAEGQTMLMQAKKENVGLQLEAAYRERAMNAYREVKKRLDYQVERQNVDRRISQKHMVDWIVNNVVKSITPDQEKENLNKCIADLGALAARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRD8</accession>
    <name>A0A182PRD8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4794 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRD8"/>
    <dbReference type="STRING" id="199890.A0A182PRD8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009522-RA">
        <property type="protein sequence ID" value="AEPI009522-PA"/>
        <property type="gene ID" value="AEPI009522"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009522"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131843" description="DUF4794 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009522-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="62314" checksum="750D796D707E1FA6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRW7</accession>
    <name>A0A182PRW7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRW7"/>
    <dbReference type="STRING" id="199890.A0A182PRW7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009702-RA">
        <property type="protein sequence ID" value="AEPI009702-PA"/>
        <property type="gene ID" value="AEPI009702"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009702"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047155">
        <property type="entry name" value="COMMD4/6/7/8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231:SF4">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009702-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="203" mass="22598" checksum="82C10F4E0AC2F311" modified="2016-09-07" version="1">MKFRFCGDGDCPDWVLAEIHSNLAQLTTDQLNDLGEHTAKSILGAEIPEAEVGKIYSIAKGSMDGPKGGIACLRFLLTSASRYNTESAVFSTELQQLGLPKEHTAIICRLLDHYVLKIRAVLREKSLSINQLDTFSCSIPKNTIDCIQLKIGIQNEVVDGLPKKTSHTVNLNRNDALLLLNELKAVRDLMESYNFDKKYSEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS30</accession>
    <name>A0A182PS30_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PS30"/>
    <dbReference type="STRING" id="199890.A0A182PS30"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009765-RA">
        <property type="protein sequence ID" value="AEPI009765-PA"/>
        <property type="gene ID" value="AEPI009765"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009765"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF86">
        <property type="entry name" value="CCP84AC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131761" evidence="3">
        <location>
            <begin position="22"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009765-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="510" mass="51750" checksum="4B071DCBE15B7421" modified="2016-09-07" version="1">MKFCVFVASLSAAVAMFGTHAAVVPVAPAVAVSTNYDPLPQYTYAYNVQDALTGDSKSQQETRDGEIVRGSYSLVEPDGTLRTVIYTADPVNGFNAVVQRGPLVPKAVVPVAAGPALLAPAPVARVLLVASLVAVSVAAPVYGPLSYGPALSYGYAAKAIQPLHTVAAAPVLHAPAVVAAAPILKHVEAYDPNPHYSFSYGVSDPHTGDSKHAEETLSNGVVHGSYSLTEPDGTIRKVTYTADKIHGFNAVVEKSGHAIHTAPVLKKVVAAAPLVAVFAALALCASAEPKPDPALVAAPLAAPLAYSAPLVQAPVVARSFAAPVAYSAPVAAYTAPVVARAAYTTPVAYSAPVVARAAPLAAAAYTAPVVAAAAAPAVVAARAAPVVAAAPVAAAPVVAARAAPVVAAAPVQAEFTDAYPQYQYAYNVQDTLTGDSKTQEETRDGDIVKGSYSLIEPDGSRRIVNYYADPINGFNAVVQKDVPVAVATPAVAVAAKTVVAPAVAAKAVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS80</accession>
    <name>A0A182PS80_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PS80"/>
    <dbReference type="STRING" id="199890.A0A182PS80"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009815-RA">
        <property type="protein sequence ID" value="AEPI009815-PA"/>
        <property type="gene ID" value="AEPI009815"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009815"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000030">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000001">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="634"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009815-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="665" mass="71969" checksum="72B2743406B06C00" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSS1</accession>
    <name>A0A182PSS1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSS1"/>
    <dbReference type="STRING" id="199890.A0A182PSS1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010007-RA">
        <property type="protein sequence ID" value="AEPI010007-PA"/>
        <property type="gene ID" value="AEPI010007"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010007"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="778"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="817"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="876"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="913"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="948"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="978"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="478"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="1058"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010007-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1173" mass="127485" checksum="DA3DF0DDBE35DDFC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTH5</accession>
    <name>A0A182PTH5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="6">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit 10</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTH5"/>
    <dbReference type="STRING" id="199890.A0A182PTH5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010261-RA">
        <property type="protein sequence ID" value="AEPI010261-PA"/>
        <property type="gene ID" value="AEPI010261"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010261"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="317"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="812"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="571"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="812"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="860"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="926"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="958"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1012"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1023"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010261-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1138" mass="134002" checksum="C3CCB9A4CDFC0191" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTM1</accession>
    <name>A0A182PTM1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTM1"/>
    <dbReference type="STRING" id="199890.A0A182PTM1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010307-RA">
        <property type="protein sequence ID" value="AEPI010307-PA"/>
        <property type="gene ID" value="AEPI010307"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010307"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF187">
        <property type="entry name" value="CYTOCHROME P450 4AE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010307-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="499" mass="57805" checksum="05E452656C989567" modified="2016-09-07" version="1">MFVLVAVFVVYLSYLLLQYHQKRQERLKILARFKGPQPHYFLGCINFYTPFPSIEIFDILVDCHREYGKDVGIIGPFNQLQLEISSAENIEKVLQVKTTKKSYPYDFLEPWLGTGLLLSFGEKWFQRRKMITPSFHFKILDQFMDVFNKEADTLVAKLERHVDQREFDIYDYITLYALDSICATSMGVHINAQEDPNNEYAQGVKKVSEYVFRRIFSILSQVPALFVLYPYARDQARVIKRLHDFTNSVIETRRKQLELENKPEKHDDFSKHRDTFLDQLLKVKIDGKPLSTADIREEVDTFMFEGHDTTTSGISFTILQLAKRQDIQQKLYEEIDTVLGESAKTMLLTNSVLQELKYLDLVIKESLRLVPPVPFIGRKLVEDMEMNGILIPAGTAISLNIFCLHRNPAVFPDPENFIPERFSDENEIKRGPYDYIPFSAGSRNCIGQKYALLEMKVTIVKLLVSYRILPGESIDQVRYKADLVLRPDGGIPVKLARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTM2</accession>
    <name>A0A182PTM2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Non-specific protein-tyrosine kinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTM2"/>
    <dbReference type="STRING" id="199890.A0A182PTM2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010308-RA">
        <property type="protein sequence ID" value="AEPI010308-PA"/>
        <property type="gene ID" value="AEPI010308"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010308"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051286">
        <property type="entry name" value="JAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016251">
        <property type="entry name" value="Tyr_kinase_non-rcpt_Jak/Tyk2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807:SF7">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01823">
        <property type="entry name" value="JANUSKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="FERM" evidence="13">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="479"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="872"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="813"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="904"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010308-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1146" mass="132452" checksum="21ED41975F82C5BE" modified="2019-01-16" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUV8</accession>
    <name>A0A182PUV8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUV8"/>
    <dbReference type="STRING" id="199890.A0A182PUV8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010745-RA">
        <property type="protein sequence ID" value="AEPI010745-PA"/>
        <property type="gene ID" value="AEPI010745"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010745"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131841" description="Vitellogenin domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="4">
        <location>
            <begin position="41"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010745-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="103" mass="12158" checksum="865FFC35B979FE09" modified="2016-09-07" version="1">MIAKLLLLTFVGLCTAYQYSSEYEFPYSRPFNKTGFEFGAWEPNREYVYNVTTKTMTALPDLEDYWTGIVTHGYLVIRPKDHNYVVAYIDRPMYAAFNEYLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVA6</accession>
    <name>A0A182PVA6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHHC U11-48K-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVA6"/>
    <dbReference type="STRING" id="199890.A0A182PVA6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010893-RA">
        <property type="protein sequence ID" value="AEPI010893-PA"/>
        <property type="gene ID" value="AEPI010893"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010893"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051591">
        <property type="entry name" value="UPF0224_FAM112_RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402:SF5">
        <property type="entry name" value="GAMETOCYTE SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402">
        <property type="entry name" value="GAMETOCYTE SPECIFIC FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="CHHC U11-48K-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010893-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="162" mass="18564" checksum="7DF3D2370DFFF94A" modified="2016-09-07" version="1">MNTMDIPNYGMVAICPYDKNHVILVERFSNHLLRCRRQHPNAKKVICPINSAHHVPEPELSLHTKNCAAVESFKHPSSTNQISPAQTSMSVGAVDSSVEAESRPREDVPSNEENWDDMDEPPYNPETYCLNNPIIRKARNLTKAQKHRFYEAERARHNSFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWP9</accession>
    <name>A0A182PWP9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWP9"/>
    <dbReference type="STRING" id="199890.A0A182PWP9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011386-RA">
        <property type="protein sequence ID" value="AEPI011386-PA"/>
        <property type="gene ID" value="AEPI011386"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011386"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011386-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="114" mass="12939" checksum="910CC9AAC6ED512F" modified="2016-09-07" version="1">MLSLSPGKFQKSDEQEVTRLRLSRNDNPFVQKVLASRDNVTDVIDDTTESDDAILILMSDEFNGETETDPLALPQVHEHMIRSPPPTFWPRSQKTMFNFGVEERTRTGGTESIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYX7</accession>
    <name>A0A182PYX7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PYX7"/>
    <dbReference type="STRING" id="199890.A0A182PYX7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015045-RA">
        <property type="protein sequence ID" value="AEPI015045-PA"/>
        <property type="gene ID" value="AEPI015045"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015045"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF46">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="561"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015045-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="902" mass="104758" checksum="15E2F611DE806203" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PK86</accession>
    <name>A0A240PK86_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division cycle protein 27 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PK86"/>
    <dbReference type="STRING" id="199890.A0A240PK86"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015292-RA">
        <property type="protein sequence ID" value="AEPI015292-PA"/>
        <property type="gene ID" value="AEPI015292"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015292"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="594"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="628"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="696"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="783"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="792"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015292-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="877" mass="96567" checksum="FDDA7AA89E18DFA2" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PPQ2</accession>
    <name>A0A240PPQ2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prolylcarboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PPQ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015284-RA">
        <property type="protein sequence ID" value="AEPI015284-PA"/>
        <property type="gene ID" value="AEPI015284"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015284"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF5">
        <property type="entry name" value="RE36938P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012014871" description="Prolylcarboxypeptidase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015284-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55452" checksum="37F0C195E26170B5" modified="2017-10-25" version="1">MATPGALFRVAILSALAAVAFGSKGGLPLMLDLFHPRSDANVPSGYVSKRSEAFRFRTRVDHFDVQNRATFEFDYVSNDEYYRPGGPIFIIVGGNNALNPYFIENGLFHDIAREQGAWLFSNEHRYYGRSAPVEDYSAPNMRFLSVEQALLDLIEWIDHLRREVVGDPSAKVILHGLGYGGAVATWARQRFPGLIDGAWSSSPSVIARANFAEYGKDMGETIRTLGSDECYGVVWRGFRTAENLMDAGLYGLLTEMFRTCVPLRADDPLTIETFFFGLKGSFEAEMFGQASADSVTRMCDDLLADQADTALHVLANLFERRYGVFDCVPFDFESSVASALDEEVGVPNNAEYGIRQRLYQLCTEFGWFVTSATGDSPFGTRITYRYFIDTCRAAFGEWIDQEVVYEGVRLTNVHFGADDPRVTNVLYVNAQYNPTRLVSITNYTNLQANAFLIEGEVAAFDWMADAEIDSEDLRRVKREIVGYVTSWLGSGIVPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWK7</accession>
    <name>A0A3F2YWK7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWK7"/>
    <dbReference type="STRING" id="199890.A0A3F2YWK7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015445-RA">
        <property type="protein sequence ID" value="AEPI015445-PA"/>
        <property type="gene ID" value="AEPI015445"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015445"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF12">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="137"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015445-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="318" mass="37110" checksum="EB6608799D19F3B4" modified="2019-01-16" version="1">MSFNQDELEAPAWLNDDFFRDVMREANNDPTIELTSACVLRPGTNKGDHYASVMFRTTVTYRSQCSKEEKSVNLIMKTKPEAEGLKKDLLEDDGLFRIEIDMYSKTLPEIARLMKEIGEEYKYPRYIYGALKPRTILILEDISGEGWVMADFISTLDDMKPIVKDIAMFHAASVVLESSDSTFVERYSYTFAEKFMGFKGMITKGFGDLMQLTQKYPEFAHFAKPLEKFQEKLHDLFVSQYDPSKTYQNVLIHGDFHYKNMLHKLDAEGRHTDTILLDYQICCWTSPAIDLYNLLDMIPTQELKDQYRSELIYMYYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FGK7</accession>
    <name>A0A9I3FGK7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A9I3FGK7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015490-RA">
        <property type="protein sequence ID" value="AEPI015490-PA"/>
        <property type="gene ID" value="AEPI015490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052295">
        <property type="entry name" value="Odorant-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066:SF3">
        <property type="entry name" value="IP02236P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066">
        <property type="entry name" value="ODORANT-BINDING PROTEIN 59A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039935768" evidence="8">
        <location>
            <begin position="22"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015490-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="174" mass="19833" checksum="EBB37285F682993E" modified="2023-06-28" version="1">MECSWPLFLCSFLLLVLGTAANQCIDMEAHREEVTQCCRHEAFSTEEVFEKCYRELSRQLAPDTPDFTVCFLDCTYREMGYLNEANEIQLPKYIEFLTAFENTYQVAVANALNACNAIKADIRRDVQNLATKCDAFALLFHVCVTQLTMENCPADRWTASDICAQVKMNVPPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZE9</accession>
    <name>A0A182NZE9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Diacylglycerol kinase</fullName>
            <shortName evidence="15">DAG kinase</shortName>
            <ecNumber evidence="15">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="15"/>
    <dbReference type="STRING" id="199890.A0A182NZE9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000029-RA">
        <property type="protein sequence ID" value="AEPI000029-PA"/>
        <property type="gene ID" value="AEPI000029"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000029"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20800">
        <property type="entry name" value="C1_DGK_typeII_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09507">
        <property type="entry name" value="SAM_DGK-delta-eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000021">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000001">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000002">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000029">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000001">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
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        </location>
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        </location>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1778" mass="198851" checksum="CC1FD4D8B64D4481" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZJ3</accession>
    <name>A0A182NZJ3_9DIPT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000074-PA"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="276" mass="31255" checksum="0B22DAF4B6304ED7" modified="2016-09-07" version="1">MKVFIVLAVSIASLAGSGYAAQVATGQKKAVDKRSPWQLGSFYSGFGDSLARSDDAHGHGVGSFGEQQFGGGWHQEYQPQSHHWAQADHEPKSLSHHPVHEWQAERAPQHHFDEHAQQQPQQFHYGGSFEQPKVEQSYGWHQQTLQDEDASKDWGLQQQQHQSLQQGGSSHEWSHDEGKEKDAGHGDWAPVSAGSSDLLKEHSAHSVSTESKEHLHQEWAPIEGKAEEHKEEHHHTKIIKVPYPVHIEKPYPVYIEKPFIVEKPVPLKLYIKKKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZK1</accession>
    <name>A0A182NZK1_9DIPT</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZK1"/>
    <dbReference type="STRING" id="199890.A0A182NZK1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000082-RA">
        <property type="protein sequence ID" value="AEPI000082-PA"/>
        <property type="gene ID" value="AEPI000082"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000082"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF203">
        <property type="entry name" value="FI18611P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Howell P."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
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                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
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                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
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                <person name="Larimer J."/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.</text>
            <dbReference type="EC" id="3.6.1.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.1.45" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A182P1Q4"/>
    <dbReference type="STRING" id="199890.A0A182P1Q4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000836-RA">
        <property type="protein sequence ID" value="AEPI000836-PA"/>
        <property type="gene ID" value="AEPI000836"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000836"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008768">
        <property type="term" value="F:UDP-sugar diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18887">
        <property type="entry name" value="NUDIX_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000035">
        <property type="entry name" value="Uridine diphosphate glucose pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004385">
        <property type="entry name" value="NDP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00052">
        <property type="entry name" value="nudix-type nucleoside diphosphatase, YffH/AdpP family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF15">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="39"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000836-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="211" mass="23532" checksum="05ADA6BB46F9233F" modified="2016-09-07" version="1">MNNITDIHYGPLPADSPYVKPFRFHYTQNGKQKSWDLLKVHDSVSIVIFNVTRKKLVFVKQFRPAVYHGIISSDGVQPGSIDMVKYPPELAVTMELCAGIIDKPISTIEIAREEILEECGYDIPVERIEEIIRYRSGVGTSGAEQTLFYAEVTDADKIATAGGGVDDEMIDVVEYDLEEARKLTAKGTVISSPPSFLFGLLWFLCNRAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1V1</accession>
    <name>A0A182P1V1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1V1"/>
    <dbReference type="STRING" id="199890.A0A182P1V1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000885-RA">
        <property type="protein sequence ID" value="AEPI000885-PA"/>
        <property type="gene ID" value="AEPI000885"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000885"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052384">
        <property type="entry name" value="TMTC_O-mannosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000885-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="114" mass="12917" checksum="2B8819D48FC2D04A" modified="2016-09-07" version="1">MGRNLNYLTFGLRSVWFHATNVALHAAATMLFTRVCLTIAGLRKNFAILAGVLFAVHPIHTEATNRKVYNPDPEVQKRTKLPVRLIFVYNSPHHCHGVLAKKTTSLICRLYWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1Z7</accession>
    <name>A0A182P1Z7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="4 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4 18"/>
    <dbReference type="AlphaFoldDB" id="A0A182P1Z7"/>
    <dbReference type="STRING" id="199890.A0A182P1Z7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000931-RA">
        <property type="protein sequence ID" value="AEPI000931-PA"/>
        <property type="gene ID" value="AEPI000931"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000931"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000029">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="17 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 18" id="KW-0408">Iron</keyword>
    <keyword evidence="14 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="40"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000931-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="290" mass="32647" checksum="5C3E2CBA241F6085" modified="2016-09-07" version="1">MTVIAADLKFLLACRGTFGQIRNIHLAAANNAAAKKVKKFQIYRWNPDKPEEKPYNQTYEVDLSACGPMVLDALIKIKNEMDPTLTFRRSCREGICGSCAMNIGGTNTLACISKIDADNLDKPTKIYPLPHMYVVKDLVPDMNNFYNQYRSIQPWLQRKNEKTEKKGDAQYLQSVDDRAKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWIIDSRDESTAARLDKLKDPFSVYRCHTIMNCTRTCPKGLNPGKAIAEIKKLLSGIAKKDAPGLETAALHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P203</accession>
    <name>A0A182P203_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aromatic-L-amino-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P203"/>
    <dbReference type="STRING" id="199890.A0A182P203"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000937-RA">
        <property type="protein sequence ID" value="AEPI000937-PA"/>
        <property type="gene ID" value="AEPI000937"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000937"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000018">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000937-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="71679" checksum="D5E575345A618C66" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2C8</accession>
    <name>A0A182P2C8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2C8"/>
    <dbReference type="STRING" id="199890.A0A182P2C8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001062-RA">
        <property type="protein sequence ID" value="AEPI001062-PA"/>
        <property type="gene ID" value="AEPI001062"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001062"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130745" evidence="1">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001062-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="87" mass="10147" checksum="0A757D7E6A4FACAD" modified="2016-09-07" version="1">MASGHFFWAIFYFACLCSASLANNAKVNFREKEKKILDQILGAGKYDARIRPSGVNGTEYMQLRNNYFVYFIQRRVRARIVLLQYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2H2</accession>
    <name>A0A182P2H2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Putative inositol monophosphatase 3</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Inositol-1(or 4)-monophosphatase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Myo-inositol monophosphatase A3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182P2H2"/>
    <dbReference type="STRING" id="199890.A0A182P2H2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001106-RA">
        <property type="protein sequence ID" value="AEPI001106-PA"/>
        <property type="gene ID" value="AEPI001106"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001106"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052834">
        <property type="term" value="F:inositol monophosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01640">
        <property type="entry name" value="IPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000012">
        <property type="entry name" value="Blast:Putative inositol monophosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000007">
        <property type="entry name" value="Blast:Putative inositol monophosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF4">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001106-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="346" mass="38312" checksum="349D03A219F9FB6B" modified="2016-09-07" version="1">MNLGRSIRINKCGVVILGLLFMCILYYLWSSNSANGATYAFSKNPNEINLRKLLIGSIQAAQHGGFEVVAVSKSRDLHEQSKGKTKEGANNPVTDADYRSNCVMKNGLLRIFPKLKVISEEDDRQEQCADVQLFDLDPTVLPEGVTVPDERVNIDEVDVWIDPLDATQEYTERLHEYVTTMVCVAVKGIPTIGIIHNPFTMKTVWAWRDKALPESLVNLKHDSDVKHPTIIVSRSHAGAVKEQSKQIFGENAQVITAGGAGFKVLQVIQNNATAYLHTTHIKKWDICAGDAILGAIGGKMSDLHNENIVYHRDTPALNPNGLLAAALSSTHEAYIKRIVESKRFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2Q1</accession>
    <name>A0A182P2Q1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gamma-tubulin complex component</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2Q1"/>
    <dbReference type="STRING" id="199890.A0A182P2Q1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001185-RA">
        <property type="protein sequence ID" value="AEPI001185-PA"/>
        <property type="gene ID" value="AEPI001185"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001185"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Arachchi H.M."/>
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</entry>
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                <person name="Haas B."/>
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                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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            <strain evidence="3">Epiroticus2</strain>
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            <strain evidence="2">Epiroticus2</strain>
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</entry>
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                <person name="Howell P."/>
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                <person name="Chapman S.B."/>
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                <person name="Gujja S."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P484"/>
    <dbReference type="STRING" id="199890.A0A182P484"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001720-RA">
        <property type="protein sequence ID" value="AEPI001720-PA"/>
        <property type="gene ID" value="AEPI001720"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001720"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001720-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="102" mass="11237" checksum="672361E41C45A981" modified="2016-09-07" version="1">VILLDLQGPVFLAEPPYKVEFSNNSGGVIDCTGHGSPPPDVEWSVATTNHELVYTLPNGSLIFYPFSADKFRHEVHSTVYRCKLKNLVGTILSREVHVKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4A1</accession>
    <name>A0A182P4A1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHHC U11-48K-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4A1"/>
    <dbReference type="STRING" id="199890.A0A182P4A1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001737-RA">
        <property type="protein sequence ID" value="AEPI001737-PA"/>
        <property type="gene ID" value="AEPI001737"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001737"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051591">
        <property type="entry name" value="UPF0224_FAM112_RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402:SF5">
        <property type="entry name" value="GAMETOCYTE SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402">
        <property type="entry name" value="GAMETOCYTE SPECIFIC FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="CHHC U11-48K-type" evidence="4">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001737-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="69" mass="8295" checksum="601396E629CBD1CD" modified="2016-09-07" version="1">MLDEMLVCPYNESHVIVRHRMPYHLVKCKKNHQENGTLQACPFNAMHVVRKVDIRQHIESCPDYRRQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P513</accession>
    <name>A0A182P513_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P513"/>
    <dbReference type="STRING" id="199890.A0A182P513"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002000-RA">
        <property type="protein sequence ID" value="AEPI002000-PA"/>
        <property type="gene ID" value="AEPI002000"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002000"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF69">
        <property type="entry name" value="SI:CH73-59F11.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002000-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="222" mass="25871" checksum="9960A478F82749E9" modified="2016-09-07" version="1">MDESTQDSPLFSEPKLIELVKRKPLLWNHKDPYYNNRKLERDCWAEIGDLLDTDVESCKKKWQSLRNQYRRELYCRTTPSKWKHYNRLSFLATVLNSKVLKRPPREHIKSEDEEDPIRVERPETPMEQNSSYSMEELCETPYSNGLVTKIDHKSTPSTSTLPATVGNVAKESNYHFALSLVGLLDSVPKRKQLAVRIAILSKINDFLPKEEDATEDDKNDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5D3</accession>
    <name>A0A182P5D3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5D3"/>
    <dbReference type="STRING" id="199890.A0A182P5D3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002123-RA">
        <property type="protein sequence ID" value="AEPI002123-PA"/>
        <property type="gene ID" value="AEPI002123"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002123"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF155">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="346"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="465"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="589"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="685"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="694"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002123-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1052" mass="113251" checksum="DBB4836711892962" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5P5</accession>
    <name>A0A182P5P5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5P5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002236-RA">
        <property type="protein sequence ID" value="AEPI002236-PA"/>
        <property type="gene ID" value="AEPI002236"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002236"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002236-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="14956" checksum="A372EB9B145659BB" modified="2016-09-07" version="1">MATETENKPVVAGEEEKKVEQQPAAAPATNEAAAASAGDKPAEGAAAAAAGGAGDAADKKPEEKAAADAPATAEGGDGATSSDAAAPAAKKEKELKPTVHKANFEKDVVYLYQFTRTPMLPSISPFCLKVETWLRLAGLKYERRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5V8</accession>
    <name>A0A182P5V8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P5V8"/>
    <dbReference type="STRING" id="199890.A0A182P5V8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002299-RA">
        <property type="protein sequence ID" value="AEPI002299-PA"/>
        <property type="gene ID" value="AEPI002299"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002299"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11328">
        <property type="entry name" value="AmyAc_maltase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF234">
        <property type="entry name" value="MALTASE A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131009" description="alpha-glucosidase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="30"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="623"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002299-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1172" mass="134179" checksum="3DB4B44E202B0327" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6A0</accession>
    <name>A0A182P6A0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6A0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002448-RA">
        <property type="protein sequence ID" value="AEPI002448-PA"/>
        <property type="gene ID" value="AEPI002448"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002448"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002448-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="583" mass="64166" checksum="D95E6E3C4E422295" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6D3</accession>
    <name>A0A182P6D3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">ATP-dependent DNA helicase Q4</fullName>
            <ecNumber evidence="17">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">DNA 3'-5' helicase RecQ4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">DNA helicase, RecQ-like type 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">RecQ protein-like 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 30">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 31">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="17"/>
    <dbReference type="STRING" id="199890.A0A182P6D3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002481-RA">
        <property type="protein sequence ID" value="AEPI002481-PA"/>
        <property type="gene ID" value="AEPI002481"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002481"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18018">
        <property type="entry name" value="DEXHc_RecQ4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22289">
        <property type="entry name" value="RecQL4_SLD2_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000772">
        <property type="entry name" value="ATP-dependent DNA helicase Q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1460:FF:000001">
        <property type="entry name" value="DNA replication regulator Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001084">
        <property type="entry name" value="RecQ like helicase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF108">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="25">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="26">
        <location>
            <begin position="907"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="27">
        <location>
            <begin position="1086"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="405"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="788"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00084018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002481-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1614" mass="179553" checksum="E373FF23FAE7C377" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6I2</accession>
    <name>A0A182P6I2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein regulatory complex protein 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DRC10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6I2"/>
    <dbReference type="STRING" id="199890.A0A182P6I2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002530-RA">
        <property type="protein sequence ID" value="AEPI002530-PA"/>
        <property type="gene ID" value="AEPI002530"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002530"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042815">
        <property type="entry name" value="DRC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002530-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="570" mass="67528" checksum="133DD8D3E872DA6A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6M9</accession>
    <name>A0A182P6M9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P6M9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002577-RA">
        <property type="protein sequence ID" value="AEPI002577-PA"/>
        <property type="gene ID" value="AEPI002577"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002577"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="137"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="466"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1369"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1102"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1127"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1139"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1178"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1212"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1240"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1304"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1379"/>
            <end position="1391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002577-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1391" mass="155580" checksum="31229ADA9FB96D25" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7F4</accession>
    <name>A0A182P7F4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Methyltransferase HEMK2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">HemK methyltransferase family member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysine N-methyltransferase 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methylarsonite methyltransferase N6AMT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Methyltransferase N6AMT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protein N(5)-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16223"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer; heterodimerization with TRMT112 is required for S-adenosyl-L-methionine-binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7F4"/>
    <dbReference type="STRING" id="199890.A0A182P7F4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002856-RA">
        <property type="protein sequence ID" value="AEPI002856-PA"/>
        <property type="gene ID" value="AEPI002856"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002856"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000077">
        <property type="entry name" value="HemK methyltransferase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="17">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002856-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="226" mass="25175" checksum="D4A72AF023CF4CE5" modified="2016-09-07" version="1">METPVYKFEPHDYDTVYEPSEDTFLLLDVLEEELDALKVRKPSMCIEIGPGSGVVLVALAKHLPVGQTHCLGFDINPNACRMTQKTGQLNGTPVEVVNMDLLAGLRSGCVDLLLFNPPYVPTQPAATGSLEEHIDEFHSSTEGQSLVHAWAGGAYGRVVTDRVLADLDRILSPDGLFYLLLLKENKPEEVLEHMKGKNFHGSIIKERRIRGEHLYVLRIERSKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7Y7</accession>
    <name>A0A182P7Y7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7Y7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003040-RA">
        <property type="protein sequence ID" value="AEPI003040-PA"/>
        <property type="gene ID" value="AEPI003040"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003040"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003040-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="90" mass="10803" checksum="D97C9DC57DA0C0A1" modified="2016-09-07" version="1">MLLLLSLNNAFKFFVIPKTLEEIRYEELRQILLQQLDQKRIRFVESIKFRNIRQQKEIPPTFKESFDIAINMETTHKITREVGTVSYVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P862</accession>
    <name>A0A182P862_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P862"/>
    <dbReference type="STRING" id="199890.A0A182P862"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003115-RA">
        <property type="protein sequence ID" value="AEPI003115-PA"/>
        <property type="gene ID" value="AEPI003115"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003115"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003115-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="226" mass="25751" checksum="DB0042A5BFB0959A" modified="2016-09-07" version="1">EEEDEEEDEEEEDEHSEVSRQVRPFGDVAFEDGLRLWALQNSLTHHALNQLLAHFRQHIPQYSLPEDSKTFLNPPATHVTNAEITKITGGQMWYQGIKKCLEMYFRDVPPTEDGLVIDFFVNGQPLQMLEQFVANYGTVYSTTLLDSNVHNLLHVHKDVKRYGDLSTLSAYPFEAKVQDLKKLVRSGRHRLLQAANRIHELQQIDVARSPSDASEGQASVHSSSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P869</accession>
    <name>A0A182P869_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P869"/>
    <dbReference type="STRING" id="199890.A0A182P869"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003122-RA">
        <property type="protein sequence ID" value="AEPI003122-PA"/>
        <property type="gene ID" value="AEPI003122"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003122"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000355">
        <property type="entry name" value="Potassium voltage-gated channel, KQT-like subfamily, member 1.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF9">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="2">
        <location>
            <begin position="11"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003122-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="121" mass="13533" checksum="4863085D151220A2" modified="2016-09-07" version="1">MEKDVRGTKFSNFAQALWWGVITLCTVGYGDMVPETWQGKIIASFCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQSLWRCYAADEHSMSEATWKIHQVPLPSPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8Q0</accession>
    <name>A0A182P8Q0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8Q0"/>
    <dbReference type="STRING" id="199890.A0A182P8Q0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003304-RA">
        <property type="protein sequence ID" value="AEPI003304-PA"/>
        <property type="gene ID" value="AEPI003304"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003304"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="48"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003304-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="104" mass="11559" checksum="FADED2A27BAC3CB8" modified="2016-09-07" version="1">MTSPSAAAANETGAGPFEEYELFYRHSYTMTAVYCVAYFIVFIVGLVGNSFVIAVVFRAPRMRTVTNFFIVNLAVADVLVIVFCLPATLMSNIFVQPNKFIKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8S8</accession>
    <name>A0A182P8S8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="3">2.7.1.150</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13610"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC13 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="3"/>
    <dbReference type="STRING" id="199890.A0A182P8S8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003332-RA">
        <property type="protein sequence ID" value="AEPI003332-PA"/>
        <property type="gene ID" value="AEPI003332"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003332"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052810">
        <property type="term" value="F:1-phosphatidylinositol-5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15725">
        <property type="entry name" value="FYVE_PIKfyve_Fab1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000057">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="12 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="22">
        <location>
            <begin position="188"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="23">
        <location>
            <begin position="1590"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="402"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="808"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1376"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1556"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1632"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="115"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="837"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1376"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1413"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1464"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1639"/>
            <end position="1653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003332-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1934" mass="214104" checksum="A472D4C360E35ADC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9H9</accession>
    <name>A0A182P9H9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vesicle transport through interaction with t-SNAREs homolog 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Vesicle transport v-SNARE protein Vti1-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Vti1-rp2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with distinct SNARE complexes that contain either STX5 or STX6. Interacts with NAPA and, to a lesser extent, with NAPG. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9H9"/>
    <dbReference type="STRING" id="199890.A0A182P9H9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003584-RA">
        <property type="protein sequence ID" value="AEPI003584-PA"/>
        <property type="gene ID" value="AEPI003584"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003584"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15891">
        <property type="entry name" value="SNARE_Vti1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000078">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000001">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs homolog 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="16">
        <location>
            <begin position="118"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003584-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="216" mass="24917" checksum="AAEBA955077C66A4" modified="2016-09-07" version="1">MELIQDYEQQYAVQTAEITAQIGRIALASGAERNKLISDVDRQLEESQELLEQIGLEIRDIPQNSRAAYTSRLNCYQAEWKRLQQEFNNAKVARSKAGYDSSVDDFDEIGIQEDQKRRLLDNTERLERTSNYLNDAYRISVETEQIGTQVLADLSQQRETIQRSRGRLRETDADLSRSSRILNSMIMRAMREKFILVAVVVAIFLVLILSIYFSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9W1</accession>
    <name>A0A182P9W1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial folate transporter/carrier</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9W1"/>
    <dbReference type="STRING" id="199890.A0A182P9W1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003715-RA">
        <property type="protein sequence ID" value="AEPI003715-PA"/>
        <property type="gene ID" value="AEPI003715"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003715"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000090">
        <property type="entry name" value="Folate transporter 1, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000073">
        <property type="entry name" value="folate transporter 1, chloroplastic isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="36"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="133"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="235"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003715-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36595" checksum="C3D8FDB1D427263D" modified="2016-09-07" version="1">MASTLKNKTAAAAGAATAGAAGAAKGNFGWLAHVKYEHLVAGISGGVTSTLLLHPLDLIKIRFAVNDGRTASVPQYRGLTSAFLTIFRQEGFRGLYKGVTPNMWGSGSAWGFYFMFYNTIKTWIQDGNTAQPLGPSLHMLAAAEAGVLTLAMTNPIWVVKTRLCLQCNERPTGTGYAGMVDGLTKIYRTEGIRGLYRGFVPGMFGVSHGALQFMTYEEMKNKYNQHRKRPIDAKLTTSEYLTFAAVSKLIAAAGTYPYQVIRARLQDQNHSYKGTWDCVKLTWRYESWRGFYKGLGPNLTRVVPATMVTFLTYEKVSHYLLDRSKARSISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA05</accession>
    <name>A0A182PA05_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spliceosome-associated protein CWC27 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this complex as he matures to the spliceosome C complex. Component of the minor spliceosome, which splices U12-type introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PA05"/>
    <dbReference type="STRING" id="199890.A0A182PA05"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003759-RA">
        <property type="protein sequence ID" value="AEPI003759-PA"/>
        <property type="gene ID" value="AEPI003759"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003759"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22288">
        <property type="entry name" value="CWC27_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000108">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003759-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="479" mass="54799" checksum="BD6C3B594688193C" modified="2016-09-07" version="1">MSNIYIQEPPTSGKARLWMKQTTKGYYNGTIFHRVVKGFIAQGGDPNGDGTGGESVYGHPFKDEFHSRLRYVRRGLVGMANSGKNDNASQFFFTLGPTPELQNQNTLFGKVAGDTIYNMLKLEEGEVYENERPHFTHRIIRTEVLNNPFDDIVPRRDANRGQSKQETDNSEKKGKMGKGVKNFGLLSFGDEAEEEELESQVYVQKNASGRGKSSHDVLDDPKLSKQTGAIVEYELSKRGRESSGTEDSSTSNSDNKDSKNHQRLLAKEFEEVSAKSIREKLQRKPDECASKKSEASDASESDSGSDYGIGHERKKAKKEEAEKIRQEINKLKRDYHTDKRSKDKEKESEQKKSSKKSSRNEVMEEVLKVQEEYAQKSKQVPKKGSSRENFTMQLLQKFKSKLHSAYECEPSNSERDDEEEDIRGDKWLAHRLEFEKKDPILAKDAATKDDDWYDVYDPRNPLNKRKRGEKIDRTKKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA79</accession>
    <name>A0A182PA79_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein CEBPZOS</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PA79"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003833-RA">
        <property type="protein sequence ID" value="AEPI003833-PA"/>
        <property type="gene ID" value="AEPI003833"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003833"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037764">
        <property type="entry name" value="CEBPZOS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38001">
        <property type="entry name" value="PROTEIN CEBPZOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38001:SF1">
        <property type="entry name" value="PROTEIN CEBPZOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003833-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10584" checksum="3CE3307E7D938915" modified="2016-09-07" version="1">MLQKKARPGYIQFIKTSAKTLIVVEALLFAFSYAGWYRLNTNREFRYYVKKNYPSILEAYYQLGETLGGDKSIRTYDENIWQQEQQAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA84</accession>
    <name>A0A182PA84_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein HIRA</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PA84"/>
    <dbReference type="STRING" id="199890.A0A182PA84"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003838-RA">
        <property type="protein sequence ID" value="AEPI003838-PA"/>
        <property type="gene ID" value="AEPI003838"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003838"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000988">
        <property type="entry name" value="Protein HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001071">
        <property type="entry name" value="Protein HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="13">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="12">
        <location>
            <begin position="671"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="543"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003838-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="937" mass="102772" checksum="17CFB35735D9E81F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAJ1</accession>
    <name>A0A182PAJ1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAJ1"/>
    <dbReference type="STRING" id="199890.A0A182PAJ1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003945-RA">
        <property type="protein sequence ID" value="AEPI003945-PA"/>
        <property type="gene ID" value="AEPI003945"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003945"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="168"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003945-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="316" mass="36029" checksum="5E92F14AE2B175EA" modified="2016-09-07" version="1">MTSHWEDFYATHLPPNCFEDNRSLLKEFCERHYKLKSHIVLVTSGGTTVPLEHNTVRFVDNFSAGNRGSASAEYFLEHGYAVIFMHRTKSLEPFSRHFTGQQLLDMLELHEEGMSTTITVKPDSVDVLAPVLDKYKNAQETHRMLYITFTSVVDYMWLLRAACESLAPFERNAVLFLAAAVSDFYVPQDEMPTHKIQSGHGAPTISLQLVPKMLAPLVSLWVPHAYVVSFKLETDEALLIAKSRESLNKYKHKLVIANILQTRKNRVVFVTPSSNYEIVLTKDQALSGLEIEEPIVADVVRRHQDYIRESEQPAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAN6</accession>
    <name>A0A182PAN6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-methylacyl-CoA racemase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAN6"/>
    <dbReference type="STRING" id="199890.A0A182PAN6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003991-RA">
        <property type="protein sequence ID" value="AEPI003991-PA"/>
        <property type="gene ID" value="AEPI003991"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003991"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008111">
        <property type="term" value="F:alpha-methylacyl-CoA racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008206">
        <property type="term" value="P:bile acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003991-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41982" checksum="02E6CCA3FA08788E" modified="2016-09-07" version="1">MALKGLKVIEFVGLAPGPFCGMLLTDFGATVTRIDMNPRNSLDVLQGGKRSLALNMKQPKAINVVRSLCRGSDVLIEPFRPGVMEKFGLGPTILLEDNPRLVYARLTGFGQSGTHAARAGHDLNFVALSGVLSMLGRKSNKPTAPINLLADFAGGGLMCAFGILAALVERHQSGRGQIVDHAMVEGAAYVGSWLYRSQTLPVWGKAPGENILDGGAHFYNTYETKDGKFVSVGAIENKFYRVMLEGLGLDPELPQFEEEEKRRELFEATFRTKTRDEWMAIFDGKDACVFPVLTADEVESYKHNRERNVFVDYQRSVDDVIVPTPAPKLSRTPARSGVTVKERSELEMAEEILGEIGMDRKELIQLYEENVLLLSSRPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBH0</accession>
    <name>A0A182PBH0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sodium channel protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the sodium channel (TC 1.A.1.10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PBH0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004275-RA">
        <property type="protein sequence ID" value="AEPI004275-PA"/>
        <property type="gene ID" value="AEPI004275"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004275"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022843">
        <property type="term" value="F:voltage-gated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13433">
        <property type="entry name" value="Na_channel_gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000150">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000047">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000089">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000039">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000053">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000058">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000370">
        <property type="entry name" value="Sodium channel protein 60E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001696">
        <property type="entry name" value="Na_channel_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044564">
        <property type="entry name" value="Na_chnl_inactivation_gate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF62">
        <property type="entry name" value="SODIUM CHANNEL PROTEIN 60E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00170">
        <property type="entry name" value="NACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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    <sequence length="2864" mass="321857" checksum="008E22C3AE306D85" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBJ3</accession>
    <name>A0A182PBJ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cytosolic iron-sulfur protein assembly protein Ciao1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ciao1</name>
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    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
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    <comment type="function">
        <text evidence="3">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat CIA1 family.</text>
    </comment>
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        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:iron-sulfur cluster assembly"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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            <dbReference type="Proteomes" id="UP000075885"/>
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    <sequence length="341" mass="38449" checksum="D8668B93758FF116" modified="2016-09-07" version="1">MGKLELIQTLTGHTGRVWSAAWHPTGKMFASCGEDKTIRVWTETDTDRWVTQTVLTDGHTRTIRDVAWSYCGHYLASASFDTTVAVWDKKSGEFECNATLEGHDNEVKSVTWSRSGSLLATCSRDKSVWIWEIHHAPDQEDEYECVAVLNGHTQDVKKVCWQPREDVLASASYDNTIRMYRQDVADGEWEMLEPLESHTSTVWSIAFDATGKRLASCSEDKTVKVWQQYGPDNTVGIVCPERGTVWKCVCTLAGYHTRSVYDIDWCKQTGLLATACGDDMVRIFREARDSDPNEPTFELVVTVPAHSQDANKVAWHPTVPGVLLTASDDSEIKVWKYVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCF0</accession>
    <name>A0A182PCF0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Proteasome subunit beta</fullName>
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    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCF0"/>
    <dbReference type="STRING" id="199890.A0A182PCF0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004605-RA">
        <property type="protein sequence ID" value="AEPI004605-PA"/>
        <property type="gene ID" value="AEPI004605"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004605"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004605-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="227" mass="24743" checksum="BE84C48720D42B13" modified="2016-09-07" version="1">MDADCSNDWRNAHHSTGTTIMAVEFDGGVVIGADSRTSTGTYVANRVTDKLTKLTDKIYCCRSGSAADTQAIADIVAYSLNYHENQTGEAPLVEDAANEFRQYCYNYRDTLVAGIIVAGWDAKHGGQVYSVPVGGMQIRQSVTIGGSGSSYIYGFVKENYREGMTREECVEFVKKSVFHAMYHDGSSGGVCRIGVITKDGVEREVFFAPRDYENVVRRGAPAVSVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCM2</accession>
    <name>A0A182PCM2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="3">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PCM2"/>
    <dbReference type="STRING" id="199890.A0A182PCM2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004677-RA">
        <property type="protein sequence ID" value="AEPI004677-PA"/>
        <property type="gene ID" value="AEPI004677"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004677"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14143">
        <property type="entry name" value="STKc_TGFbR1_ACVR1b_ACVR1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000304">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000023">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF71">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="18">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="87"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004677-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="378" mass="42658" checksum="77836E601F55E498" modified="2016-09-07" version="1">MPAELVVIVVVIVLSLILIVTVTVICMGRRKRNSGARQILPEDSAYGASYPILNGHTTIQDFIEMTTSGSGSSGLPLLVQRSIARQIQLVEVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTIMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDFLTARCVDPDTMLEMAYSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLTCCIGDLGLAVRHNVITDTVDIPSTHRVGTKRYMAPEVLDESINVHQFDSFKRADVYALGLVLWEIARRCNVDGSYDEYQLPFYDVVQPDPTIEEMRKVVCVDQQRPCIPSRWIACDTLHAISKVMKECWYQHPAARLSALRIKKTLANLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCW2</accession>
    <name>A0A182PCW2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocon-associated protein subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Signal sequence receptor subunit delta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAP-delta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCW2"/>
    <dbReference type="STRING" id="199890.A0A182PCW2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004767-RA">
        <property type="protein sequence ID" value="AEPI004767-PA"/>
        <property type="gene ID" value="AEPI004767"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004767"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008855">
        <property type="entry name" value="TRAP-delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731:SF1">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, DELTA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05404">
        <property type="entry name" value="TRAP-delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131169" description="Translocon-associated protein subunit delta" evidence="15">
        <location>
            <begin position="21"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004767-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="170" mass="18383" checksum="381FA32192F23079" modified="2016-09-07" version="1">MVKFVLASAVLCCAMAFAVANSCTNPEVKTNFYSTNDATIVSQIGFVTEFTLKCSNAGAEKLPLFAEVLGKLAPVVRIGENKYQVSWNEEIKKASSGSYMIRLFDEESYAAVRKAQRAGEDIQAVKPLTTVTVNFPGAYKGPWVNSEILATGLAGFVAYVAFTTRSKLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDR1</accession>
    <name>A0A182PDR1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDR1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005066-RA">
        <property type="protein sequence ID" value="AEPI005066-PA"/>
        <property type="gene ID" value="AEPI005066"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005066"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131172" evidence="1">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005066-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="80" mass="8158" checksum="F128448FAEF146F9" modified="2016-09-07" version="1">MFAKIIFFLGLVVAAAYGKPLFPLTYSAPLVAAPSLAVASPLATPFAAAAYTAAPVAAAYTASPYAYSAYPYSAYGSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDZ7</accession>
    <name>A0A182PDZ7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDZ7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005152-RA">
        <property type="protein sequence ID" value="AEPI005152-PA"/>
        <property type="gene ID" value="AEPI005152"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005152"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005152-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="653" mass="69690" checksum="E86BE06AD3B9D5EF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEM2</accession>
    <name>A0A182PEM2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182PEM2"/>
    <dbReference type="STRING" id="199890.A0A182PEM2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005377-RA">
        <property type="protein sequence ID" value="AEPI005377-PA"/>
        <property type="gene ID" value="AEPI005377"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005377"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000001">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1130">
        <property type="entry name" value="Rab geranylgeranyltransferase alpha-subunit, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005377-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="532" mass="61203" checksum="F6B7038ED8C5A2FF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEY5</accession>
    <name>A0A182PEY5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RYamide</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEY5"/>
    <dbReference type="STRING" id="199890.A0A182PEY5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005490-RA">
        <property type="protein sequence ID" value="AEPI005490-PA"/>
        <property type="gene ID" value="AEPI005490"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005490"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131233" description="RYamide" evidence="2">
        <location>
            <begin position="40"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005490-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20232" checksum="4F4CD6CF554DA8A0" modified="2016-09-07" version="1">MTWRTMKPLARQQSFAFCISTTVGLVLFCALALAAVTDADPMVDSASSLYGDNKHASDKRPFFVGSRYGRSQVYGAKDLRQVNVVPRNDRFFLGSRYGKRSDLTKEIESDSNNGIAELTYLACLHTGVSNLYRCYSRDSSSNAVHQQQETADQFEQEQQQQQHHRLPHQFNDNGDLSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF90</accession>
    <name>A0A182PF90_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PF90"/>
    <dbReference type="STRING" id="199890.A0A182PF90"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005596-RA">
        <property type="protein sequence ID" value="AEPI005596-PA"/>
        <property type="gene ID" value="AEPI005596"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005596"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005596-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="351" mass="36957" checksum="42CABB878C242B10" modified="2016-09-07" version="1">MPVSAELDDDEREDDDGRPEIPARRQDRDEEDEEEEDEEEDDLISVAGHEPDPTPVVQCHHERPMGSKSPYTMRPQYDHGSRSSMSSQSSQHSSSMHLPGHGEDSRDGGPMTMPHPAAHAPDVFVPMLHVRRDLHHKMGLIGRASATITSAGSGGGLLEPSGSFLSHIPLRKRAMGPDGEPHPIMSRSFHMPPGSRGHHKSHLVEDVHSGPPDSPHREPMPLMSPSVPSASPVLLSPHLPPGHLALPPPPPPPAPSSMAVPINLANLSNLPVVLPPAPAPSGPCSSSAASPHHHPGVIASPGSSTSVTSKGSVPPAAPAASSSSTAPQVVAPAAPPPPRKTGFSIEDIMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFA9</accession>
    <name>A0A182PFA9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">coq7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A182PFA9"/>
    <dbReference type="STRING" id="199890.A0A182PFA9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005615-RA">
        <property type="protein sequence ID" value="AEPI005615-PA"/>
        <property type="gene ID" value="AEPI005615"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005615"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005615-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="191" mass="21567" checksum="60E826F2DB8B2109" modified="2016-09-07" version="1">MLQITRGVHTGRELLAQRCSKLVDSVIRVDHAGELGANQIYRGQMAILGHTKAGKTIQHMWEQEKAHKEEFDRLINKYRVRPTALLPFWNVAGFALGAGTALLGEKAAMACTVAVESVIVEHYNDQLRKLMDDPTFTDKELLDTIQRFRDEEQEHHDTGLEHGAEQAPFYRALTDVIKFGCRTAIKIAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PG08</accession>
    <name>A0A182PG08_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neuropeptide-like 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PG08"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005867-RA">
        <property type="protein sequence ID" value="AEPI005867-PA"/>
        <property type="gene ID" value="AEPI005867"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005867"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131282" description="Neuropeptide-like 4" evidence="1">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005867-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8528" checksum="6E0EADCA7CEBEFAE" modified="2016-09-07" version="1">MARKFVIAVIVAIIACTLAAPAPEPKPDPKAQLLAAAPVGYAAYPYAYTAGYVPYSGVLPYTAYAYPSLAYSYNYPYAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGT7</accession>
    <name>A0A182PGT7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGT7"/>
    <dbReference type="STRING" id="199890.A0A182PGT7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006146-RA">
        <property type="protein sequence ID" value="AEPI006146-PA"/>
        <property type="gene ID" value="AEPI006146"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006146"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="3">Epiroticus2</strain>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHM8"/>
    <dbReference type="STRING" id="199890.A0A182PHM8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006437-RA">
        <property type="protein sequence ID" value="AEPI006437-PA"/>
        <property type="gene ID" value="AEPI006437"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006437"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006437-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="453" mass="50848" checksum="4B75635FCEC6C940" modified="2016-09-07" version="1">MCSIVEDDFGDDGGAHAMKEDTPQAELAGNEICRKCNIEVAVLKLNQKDPQCRGCFLSYVRHKFRASLGSTKIVRRGSRVLIILTGTPENVTLLDMVRFGLVQDAFKQLRIVPVLLFVDDDFVETPQEDRMQQLARRMQVFKQFESFPSYYTVCGSSKHVALTFDKPFSPAGFEQDEQRLMQVLNAVRSVSSKQDLLEQMRKRTYRAIAQTLQCSYVFLSDIGVDLAKTLLSNVALGRGCSLAQDVAFCDDRDETVKLIRPIRDLNPDEVSNYLQYSETPLLSLSSEKHFEDKPSLQNLTAKFIDNLMQSFPSTVSTVYRTGDKLDAPKAAPNRSTANGAEQDAETQDLFALFDRTLQLDPPQSLGACCRFCGATLDYRGSKTLFATEYSRLVSSRINAACSHEDILQKSKQMELDAERAVNGEEDDQGERRALMKQLCHGCRNIFEDVSDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIW2</accession>
    <name>A0A182PIW2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIW2"/>
    <dbReference type="STRING" id="199890.A0A182PIW2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006875-RA">
        <property type="protein sequence ID" value="AEPI006875-PA"/>
        <property type="gene ID" value="AEPI006875"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006875"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="3">
        <location>
            <begin position="181"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006875-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="579" mass="65730" checksum="4A4361B8F5F1F5D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJC4</accession>
    <name>A0A182PJC4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJC4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007038-RA">
        <property type="protein sequence ID" value="AEPI007038-PA"/>
        <property type="gene ID" value="AEPI007038"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007038"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007038-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="121" mass="13777" checksum="B565A160C85B9557" modified="2016-09-07" version="1">ASQSGHGSGGHHKGHSSSGRRGNSQSVTIAQQSNEQSLRQRAVARLKMFNFNLNWDLHMTQCKPCGPKSSGNIITRRLCRNRRGEDNELYRSNSFKFERFERKDPMEAGARTMLRKQVRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJD7</accession>
    <name>A0A182PJD7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylulose kinase</fullName>
            <ecNumber evidence="4">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PJD7"/>
    <dbReference type="STRING" id="199890.A0A182PJD7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007051-RA">
        <property type="protein sequence ID" value="AEPI007051-PA"/>
        <property type="gene ID" value="AEPI007051"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007051"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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            <taxon>Culicidae</taxon>
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            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="3">Epiroticus2</strain>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJK8</accession>
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            <taxon>Pterygota</taxon>
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            <taxon>Diptera</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJK8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007122-RA">
        <property type="protein sequence ID" value="AEPI007122-PA"/>
        <property type="gene ID" value="AEPI007122"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007122"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702:SF1">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="96"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007122-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="225" mass="25358" checksum="9C9A7BCBF9238D72" modified="2016-09-07" version="1">MTRHALSVVVPQVLRVWRRQVGLHYLVSTICWFTLISFVWCGANNLHMNDGVRTQDIIAGDVFFEILEPSTLEYTYRLRPAKDFGGTFGISYKSQEGKLVPAVPADACSAKFENADELVGNIALVERGHCSFLTKAINVEAVGGAAMIVTEYDTEIDDFDYYIEMVHDNTDRDTDIPAGFLHGKNGIIIRQTLKKMNLPYAIVNIPVNLTFIQPHMINQPPWLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJP0</accession>
    <name>A0A182PJP0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Sodium/potassium-transporting ATPase subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJP0"/>
    <dbReference type="STRING" id="199890.A0A182PJP0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007154-RA">
        <property type="protein sequence ID" value="AEPI007154-PA"/>
        <property type="gene ID" value="AEPI007154"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007154"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1660:FF:000004">
        <property type="entry name" value="sodium/potassium-transporting ATPase subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF46">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007154-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="44969" checksum="CDE77A4132F3F79D" modified="2016-09-07" version="1">MPAEKRSSQPRIVRTYEFPTKPEKQTLGQYLYNSQDGKIMGRTSKGWAQLLFFYACFYTVLAALFAICMQGLLVTLNHQYPKWQLDESRIGTNPGVSYRPQPEDAESVNSIQYVAANKSDVAVWVNMINDFLAPYEDHTLLPGGGKNQVICDFNTPPTAGNVCAFDVKNLGPCSAAAGYSYNRSAPCIFIKINRIYGWQPEFYEDVDDLPTDMPDDLVSHIRSLPAPDRRQVWVTCKELTNSDEDQLGPIEYLPSQGFPAYYYPYMNIEGYLSPLVAVHLARPKPKTTISIECRAWAKNIIYRGGSRDRAGSVQLFLLLSQALVEDERSISGTVSVAEAVAPSSVPTRNGSVTPRTAVPLPLDVCFICADGALGECLTVGGTGRCLRSVCNASKKAAFQKRKVCQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKK7</accession>
    <name>A0A182PKK7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PKK7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007474-RA">
        <property type="protein sequence ID" value="AEPI007474-PA"/>
        <property type="gene ID" value="AEPI007474"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007474"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
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    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="10" id="KW-0243">Dynein</keyword>
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    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="4305"/>
            <end position="4329"/>
        </location>
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        <location>
            <begin position="1566"/>
            <end position="1705"/>
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        <location>
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        <location>
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            <end position="231"/>
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        <location>
            <begin position="3063"/>
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    </feature>
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        <location>
            <begin position="102"/>
            <end position="115"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007474-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="4354" mass="502563" checksum="660AC953C2DCA7AB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKP4</accession>
    <name>A0A182PKP4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Endoplasmic reticulum chaperone BIP</fullName>
            <ecNumber evidence="3">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">78 kDa glucose-regulated protein homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Binding-immunoglobulin protein homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Endoplasmic reticulum chaperone BiP</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins. Acts as a key repressor of the unfolded protein response (UPR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PKP4"/>
    <dbReference type="STRING" id="199890.A0A182PKP4"/>
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        <property type="protein sequence ID" value="AEPI007511-PA"/>
        <property type="gene ID" value="AEPI007511"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007511"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000720">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000029">
        <property type="entry name" value="Heat shock 70 kDa protein cognate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Heat_shock_70_CS"/>
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        <property type="entry name" value="HSP70_C_sf"/>
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        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131476" description="Endoplasmic reticulum chaperone BIP" evidence="19">
        <location>
            <begin position="21"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="596"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007511-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="659" mass="72674" checksum="6DA784B2BC0658D7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKR8</accession>
    <name>A0A182PKR8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKR8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007535-RA">
        <property type="protein sequence ID" value="AEPI007535-PA"/>
        <property type="gene ID" value="AEPI007535"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007535"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007535-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1003" mass="105951" checksum="7CB783711A5868F6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKS1</accession>
    <name>A0A182PKS1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKS1"/>
    <dbReference type="STRING" id="199890.A0A182PKS1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007538-RA">
        <property type="protein sequence ID" value="AEPI007538-PA"/>
        <property type="gene ID" value="AEPI007538"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007538"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF45">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 83A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00485">
        <property type="entry name" value="MEALWORMBTLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013040205" evidence="5">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007538-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="144" mass="16520" checksum="836A9AA7F2E7B49E" modified="2017-10-25" version="2">MKRLILLIVGLVCCSAILADTSPRRDAEYPPPELLEALKPLHDICVGKTGVTDEAIKKFSDEEIHEDEKLKCYMNCLFHEAKVVDDNGDVHLEKLHDSLPDSMHDIAMHMGKRCLYPEGETLCDKAFWLHKCWKQSDPKHYFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKY7</accession>
    <name>A0A182PKY7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal Pro-X carboxypeptidase</fullName>
            <ecNumber evidence="14">3.4.16.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Proline carboxypeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Prolylcarboxypeptidase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid.</text>
            <dbReference type="EC" id="3.4.16.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.2" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A182PKY7"/>
    <dbReference type="STRING" id="199890.A0A182PKY7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007604-RA">
        <property type="protein sequence ID" value="AEPI007604-PA"/>
        <property type="gene ID" value="AEPI007604"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007604"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000002">
        <property type="entry name" value="lysosomal Pro-X carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131414" description="Lysosomal Pro-X carboxypeptidase" evidence="18">
        <location>
            <begin position="23"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007604-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="483" mass="53493" checksum="0D0C76B7665B2E50" modified="2016-09-07" version="1">MTAAQWVALIIGLSAVVRDGAATYEYQTKTIDVPIDHFTYTGEATFKLRYLINDTYADKDATADPANSPILFYAGNEGDIELFAQNTGFMWELAPKLKATLLFVEHRFYGHSLPFGNASYESPKHLGYLTSEQALADFALVLRTLNPPNGTTRARPVIAFGGSYGGMLAAWIRIKYPHLVAGAIAASAPIRQFAGVTECGIFNQILTSVFQVAYNAECATNIRRSWTTLQNYSASADGLRVLNEKFKFCTNLTKATDVTETLFDYLTDVYGNLAMINYPYPSSFLAPVPAYPVREFCGRLNQTYSGAELLDQLHSALTIYYNYDGKAPCLNINSSYDGTGISDQGWDFQACTEMVMPICADGVHDMFPPQPWNMQTYADKCFKKYGVHPRPANALLNYGGEFLDATITNIVFSNGLLDPWSGGGVLRSSNENVKIVLIPEGAHHLDLRASNPADPASVTRARALHVQNIQKWLAEYRKQRKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL97</accession>
    <name>A0A182PL97_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial cardiolipin hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial phospholipase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PL97"/>
    <dbReference type="STRING" id="199890.A0A182PL97"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007714-RA">
        <property type="protein sequence ID" value="AEPI007714-PA"/>
        <property type="gene ID" value="AEPI007714"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007714"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051406">
        <property type="entry name" value="PLD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856">
        <property type="entry name" value="CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856:SF1">
        <property type="entry name" value="MITOCHONDRIAL CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase D-like" evidence="8">
        <location>
            <begin position="80"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007714-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="303" mass="35039" checksum="D0B5654F81ECEDF6" modified="2016-09-07" version="1">MAPAALQPFLSLLNNKPVKLLIAGGILIVSTEIAYELVLWWRKATKPKPKSCEVFFINRRKLVEPLPTPQDFLYEHINRIISYIDRAEKSICLAMYIFTMREICEAVIRAKRERSVVVRVVTCESMVANEGSFLRDLIAEDIKVQYKYKSEYLMHHKFCLLDTDWYCANCLIAYHTAEYGEPTKNMQHTLFDKAVMSDRAALLQRFGSSCVRCNPAERNKQDKRQRKQSNNPLPKHGLILAGSSNWTFPGLTTHWDTITVASLPELIDPFAAEFQRMWYELNDPLGLTHTREPLYKRRCGADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLN6</accession>
    <name>A0A182PLN6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PLN6"/>
    <dbReference type="STRING" id="199890.A0A182PLN6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007856-RA">
        <property type="protein sequence ID" value="AEPI007856-PA"/>
        <property type="gene ID" value="AEPI007856"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007856"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000360">
        <property type="entry name" value="RAB9B, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF1">
        <property type="entry name" value="RE17845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007856-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="233" mass="26785" checksum="B9C4FB9B46CC51D6" modified="2016-09-07" version="1">MTNMRPPSKNILLKVVILGDGNVGKSCLMNRFVSNYFDANSFHTIGVEFLNKDIQVDQERYTLQIWDTAGQERFRALRTPFYRGTDICLLTYAINDRLSFRALASWRDEFLRYYDVNPDHFPFVVVGTKNDLPPAQREVTPEEVTQWCQEHHITAHIETSAKSSENVATAFALAVQQWRKLERSTERELRAQGQDTIDLMKSVNLNANRNRFCCAGIGRPTAATMQDNDDYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLQ5</accession>
    <name>A0A182PLQ5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc carboxypeptidase A 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PLQ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007877-RA">
        <property type="protein sequence ID" value="AEPI007877-PA"/>
        <property type="gene ID" value="AEPI007877"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007877"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000002">
        <property type="entry name" value="Carboxypeptidase A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF123">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131437" description="Zinc carboxypeptidase A 1" evidence="16">
        <location>
            <begin position="20"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="116"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="545"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="935"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="1350"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="803"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="1193"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="1608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007877-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1648" mass="187453" checksum="5E4E5EED134D74BF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM56</accession>
    <name>A0A182PM56_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="13">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A182PM56"/>
    <dbReference type="STRING" id="199890.A0A182PM56"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008029-RA">
        <property type="protein sequence ID" value="AEPI008029-PA"/>
        <property type="gene ID" value="AEPI008029"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008029"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000017">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000107">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008029-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="463" mass="52212" checksum="15915315675D7D25" modified="2016-09-07" version="1">MFARAIHTKARIKALVRYPVRWYTERNLLKLKERGFIQDVFPAESIDKARSMLGSSACQTVYAGFDPTANSLHVGNLLVLIGLLHTQRAGHQPIALVGGATGLIGDPSGRKTERQQLETEIVEHNVECIKRQIETIFSNHERFFWDRPASPLKPVLVVNNADWYRQYSFVDFMANVGRHFRMGAMLSRSSVQSRLTSESGMSFTEFSYQLFQAYDWLHLLRHHNCRFQLGGSDQMGNIMSGQELISRTDGKEVFGLTLPLITNEEGDKFGKSAGNAVWLAEERTSPYTMYQFFVRTPDSEVEKLLRLLSFLPVQTIEQTMARHRRTPELWEAQKLLAAELTKLVHGETGLQKAMAISSALYNGDLSALEQLEVRDVAQSFGGAPLCEILPEPGMTVLDVALRARCFPTQADAERIIRAGGFSINLKKAKNPAEVLSPSVHILSNRISLLRVGKRNYYIVKWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PME7</accession>
    <name>A0A182PME7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PME7"/>
    <dbReference type="STRING" id="199890.A0A182PME7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008120-RA">
        <property type="protein sequence ID" value="AEPI008120-PA"/>
        <property type="gene ID" value="AEPI008120"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008120"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF106">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131658" description="Chitin-binding type-2 domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="656"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="810"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="810"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008120-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="889" mass="98507" checksum="106A272C77C97047" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN31</accession>
    <name>A0A182PN31_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PN31"/>
    <dbReference type="STRING" id="199890.A0A182PN31"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008355-RA">
        <property type="protein sequence ID" value="AEPI008355-PA"/>
        <property type="gene ID" value="AEPI008355"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008355"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131569" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="28"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="178"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008355-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="238" mass="26379" checksum="8C90E803CF53E826" modified="2016-09-07" version="1">MASVDVLIVVLLSSAFLWNSPVHGVDLSSVCKGLKFGTYPHPNDCQQYVLCVLGNPVLLSCPGGYVFHPEVQFCVQESQYHCNVTDTTASPEVTTTTTPEPSTTLVPECDHRPSWESFFCDDARRTLVANPMNCTQYIHCQLKVPSNQLCRNGTVFNDLYQDCLPGDRETCTLASVREDFCRNRTDGAYAHPFLCNRFVMCVRGELQLESCPPFYVFDPSAGHCVKGSAVTCSSLLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN99</accession>
    <name>A0A182PN99_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PN99"/>
    <dbReference type="STRING" id="199890.A0A182PN99"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008424-RA">
        <property type="protein sequence ID" value="AEPI008424-PA"/>
        <property type="gene ID" value="AEPI008424"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008424"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF237">
        <property type="entry name" value="CUTICULAR PROTEIN 65AU, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131706" evidence="3">
        <location>
            <begin position="17"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008424-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="136" mass="14545" checksum="C1758E1F07BA1467" modified="2016-09-07" version="1">MRMKFVIAALAAVAVAQNPDAEAQILSSDSSVNPDGTYAWNYETSNGIRAQEQGVGGESAQGSASWTDRDGTPISLTYVADVNGFQPQGAHLPREGPVPDHVLKALEFIRANPPKDDPNFNIQALEAEIARLQALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNC9</accession>
    <name>A0A182PNC9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNC9"/>
    <dbReference type="STRING" id="199890.A0A182PNC9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008456-RA">
        <property type="protein sequence ID" value="AEPI008456-PA"/>
        <property type="gene ID" value="AEPI008456"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008456"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026187">
        <property type="entry name" value="Aven"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16524">
        <property type="entry name" value="CELL DEATH REGULATOR AVEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16524:SF2">
        <property type="entry name" value="CELL DEATH REGULATOR AVEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008456-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="298" mass="33558" checksum="773C09E6D4ACBD98" modified="2016-09-07" version="1">MDKASFAAKRRQDKFHKKPPPPKPAKQKSGPKPPDVQHTAPLVVCDDRYGKHQIQQNWTEDRDLPTSDSEDTEDEQLQAADFEKLLELPPSSASHFLLSSEKRWLQPDTDLPGEDEKNRYSEYFRIDTKLLNASLGCIPFYERHGYEQTLFSTLELNLMRQKAELNTNKFQQSFADQLATSSVKTGPPSQNNKENMPLPRKPQPTPCFVGKFAKPPMDGSIGDRDAKQPSAGKESVGSIEEKLGELKIKPDPKQNVSKLVPIVDPTVPTPITKPATTANEVKDTKEDIQQWLDDILDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNJ3</accession>
    <name>A0A182PNJ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNJ3"/>
    <dbReference type="STRING" id="199890.A0A182PNJ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008520-RA">
        <property type="protein sequence ID" value="AEPI008520-PA"/>
        <property type="gene ID" value="AEPI008520"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008520"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000015">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF89">
        <property type="entry name" value="NEUREXIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="862"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="10">
        <location>
            <begin position="125"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="303"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="10">
        <location>
            <begin position="344"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="744"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="892"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1006"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="746"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="814"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="973"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1019"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1044"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008520-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1053" mass="112196" checksum="231C98FCD7D64871" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNR9</accession>
    <name>A0A182PNR9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNR9"/>
    <dbReference type="STRING" id="199890.A0A182PNR9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008598-RA">
        <property type="protein sequence ID" value="AEPI008598-PA"/>
        <property type="gene ID" value="AEPI008598"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008598"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="PROTEIN SCARLET"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="488"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="509"/>
            <end position="536"/>
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        <location>
            <begin position="542"/>
            <end position="566"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="578"/>
            <end position="597"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="664"/>
            <end position="683"/>
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    </feature>
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        <location>
            <begin position="81"/>
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    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008598-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="688" mass="75420" checksum="4CE07DCEDBE9CAA4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNV3</accession>
    <name>A0A182PNV3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DDX42</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DEAD box protein 42</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX42 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PNV3"/>
    <dbReference type="STRING" id="199890.A0A182PNV3"/>
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        <property type="protein sequence ID" value="AEPI008632-PA"/>
        <property type="gene ID" value="AEPI008632"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008632"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17952">
        <property type="entry name" value="DEADc_DDX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000524">
        <property type="entry name" value="ATP-dependent RNA helicase DDX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="304"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="508"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="663"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="738"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="765"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008632-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="789" mass="88056" checksum="7A62C504AE8AC4A2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP14</accession>
    <name>A0A182PP14_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L31</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP14"/>
    <dbReference type="STRING" id="199890.A0A182PP14"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008693-RA">
        <property type="protein sequence ID" value="AEPI008693-PA"/>
        <property type="gene ID" value="AEPI008693"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008693"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00410">
        <property type="entry name" value="Ribosomal_eL31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002258">
        <property type="entry name" value="PRK01192.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008693-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="124" mass="14688" checksum="6A5E60D296EEED5C" modified="2016-09-07" version="1">MVKAKREKKPKSAINEVVTRECTINLNRRLHKIGYKKRSPRAIKIVRKFAEKEMGTTDVRIDTRLNKAIWHRGIRNPPFRIRVRLSRRRNDDEDSPNKLYTLVTYVPVPSFKELQTENVESTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPN9</accession>
    <name>A0A182PPN9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein TsetseEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="EnsemblMetazoa" id="AEPI008918-RA">
        <property type="protein sequence ID" value="AEPI008918-PA"/>
        <property type="gene ID" value="AEPI008918"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008918"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131582" description="Protein TsetseEP domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008918-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1299" mass="134761" checksum="A029DB5304E20B71" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPY5</accession>
    <name>A0A182PPY5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPY5"/>
    <dbReference type="STRING" id="199890.A0A182PPY5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009015-RA">
        <property type="protein sequence ID" value="AEPI009015-PA"/>
        <property type="gene ID" value="AEPI009015"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009015"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028019">
        <property type="entry name" value="DUF4508"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16260:SF3">
        <property type="entry name" value="CHROMOSOME 14 OPEN READING FRAME 119-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16260">
        <property type="entry name" value="SIMILAR TO 1700123O20RIK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14969">
        <property type="entry name" value="DUF4508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009015-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="172" mass="19311" checksum="D2B681EDF8BBDF39" modified="2016-09-07" version="1">MSSNGSYNLTVDGELRYVVQWFEEWSDFQREDFVPYLVSYLTQQAGGMVYVNGLISAMAQINPGQDKPMSLFQCRVKLFNEWCPKWPEEFKSKLLERLEQSDSAFGARIRTELEANAKPLNGSLEDPDTQLTDTGTARDLEEKSEQAPIGLIVNAEPVIVAPSNAILVADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ45</accession>
    <name>A0A182PQ45_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQ45"/>
    <dbReference type="STRING" id="199890.A0A182PQ45"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009075-RA">
        <property type="protein sequence ID" value="AEPI009075-PA"/>
        <property type="gene ID" value="AEPI009075"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009075"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131782" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009075-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10519" checksum="9344BEB30C97386B" modified="2016-09-07" version="1">MTSVAFSVTLSTLLTLVTVVAADEIRDTREGETVTLKCRFSEQSAASDFSYYWARSTGNKFDNVAIKGVQLNTNYRVRQASGGSFVIIGETYSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ87</accession>
    <name>A0A182PQ87_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQ87"/>
    <dbReference type="STRING" id="199890.A0A182PQ87"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009117-RA">
        <property type="protein sequence ID" value="AEPI009117-PA"/>
        <property type="gene ID" value="AEPI009117"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009117"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000004">
        <property type="entry name" value="SEC24 homolog B, COPII coat complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="15">
        <location>
            <begin position="418"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="16">
        <location>
            <begin position="491"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="18">
        <location>
            <begin position="733"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="17">
        <location>
            <begin position="828"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="14">
        <location>
            <begin position="958"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009117-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1083" mass="118360" checksum="5337AD6819A6A7BA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQK2</accession>
    <name>A0A182PQK2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQK2"/>
    <dbReference type="STRING" id="199890.A0A182PQK2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009233-RA">
        <property type="protein sequence ID" value="AEPI009233-PA"/>
        <property type="gene ID" value="AEPI009233"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009233"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000037">
        <property type="entry name" value="Coenzyme Q-binding protein COQ10, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="53"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009233-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="204" mass="23492" checksum="7A9561DA4B8F9CEB" modified="2016-09-07" version="1">MSVKIVANAKHVFLSRNLAQYQRNPVLYSTYRGIFDFTPITKTRREFTQKKLVGYSMHQLYSVVADVEKYNTFVPFCKKSFVYDRKPGSLKADLIIGFPPLNESYTSNVKLIQPTLVKAECVDGRLFNYLLTAWQFSPGLKDIPQSCVIDFMVSFEFKSLLHSQLSNLFFDQIVKQMEYAFIQEAEQRFGSPAIKSHVLVSNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQS2</accession>
    <name>A0A182PQS2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQS2"/>
    <dbReference type="STRING" id="199890.A0A182PQS2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009303-RA">
        <property type="protein sequence ID" value="AEPI009303-PA"/>
        <property type="gene ID" value="AEPI009303"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009303"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000109">
        <property type="entry name" value="WD repeat domain 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="5">
        <location>
            <begin position="35"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="477"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="566"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="4">
        <location>
            <begin position="707"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009303-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="924" mass="102963" checksum="A6E3664020D673E7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRA0</accession>
    <name>A0A182PRA0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcitonin receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRA0"/>
    <dbReference type="STRING" id="199890.A0A182PRA0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009484-RA">
        <property type="protein sequence ID" value="AEPI009484-PA"/>
        <property type="gene ID" value="AEPI009484"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009484"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15260">
        <property type="entry name" value="7tmB1_NPR_B4_insect-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF43">
        <property type="entry name" value="HECTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="12">
        <location>
            <begin position="36"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="13">
        <location>
            <begin position="138"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009484-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59701" checksum="9786F51F0EAD26D9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRT9</accession>
    <name>A0A182PRT9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphatidylserine decarboxylase proenzyme, mitochondrial</fullName>
            <ecNumber evidence="13">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="13">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="13">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="13">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase alpha chain</molecule>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="13">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase beta chain</molecule>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
            <orientation evidence="13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A182PRT9"/>
    <dbReference type="STRING" id="199890.A0A182PRT9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009674-RA">
        <property type="protein sequence ID" value="AEPI009674-PA"/>
        <property type="gene ID" value="AEPI009674"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009674"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023308038" description="Phosphatidylserine decarboxylase beta chain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023308037" description="Phosphatidylserine decarboxylase alpha chain" evidence="13">
        <location>
            <begin position="415"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="13">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="13">
        <location>
            <begin position="134"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="13">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="13">
        <location>
            <begin position="414"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="13">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009674-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="496" mass="57166" checksum="1F3038E5E946959D" modified="2016-09-07" version="1">FSKAVNLKPNPRQWSTRWTIVQRSIYGTRQLQQQPNSSSSTNHQQHHQQHHQHHQHHQQQQQQFHHQSTTGKSRSKVYRKWSWKAGAGWTILSVLDWWLLAAGGWLTWRGVFLRWTPIGICMVVAAKWHLHNRELDKKGLPRTAAKWQAKMYCSLPLRLMSRCWGWMADRRVPKPVRPMLYGLYSSTFGVKMEEAAANNFKEYRSLGEFFTRPLKEDARPIDPKTSFVSPCDGRILHFGAANSNLIEQVKGVSYSLEAFLGPPTWTKKDDPEMVEKVKHNPSPDSVLYQCVIYLAPGDYHRFHSPALWKPELRRHFSGELLSVSPKIAGWIPGLFCLNERAVYIGKWKHGFFSYTAVGATNVGSVEIFMDEKLKTNKWVGLACGSHKHNEYDELEMPADKYLEKGELVGQFRMGSTIVLIFEAPKDFKFNLFPGQRVKVGERLGTFESTEESPEDPEEVKRVIKSLDELEPVSVRKKHRSGRTGERARFVCVVSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSA5</accession>
    <name>A0A182PSA5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSA5"/>
    <dbReference type="STRING" id="199890.A0A182PSA5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009840-RA">
        <property type="protein sequence ID" value="AEPI009840-PA"/>
        <property type="gene ID" value="AEPI009840"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009840"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000656">
        <property type="entry name" value="Zinc finger protein 541"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009840-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="143" mass="15181" checksum="E3129872B1C58F74" modified="2016-09-07" version="1">DCSLKGRIIHLTLSVPSIPQVCSKVFGNASALAKHKLTHSDERKYVCGMCSKAFKRQDHLNGHMLTHRNKKPYECKAEGCGKSYCDARSLRRHTENHHSALGLGNSSGTASPGPVGSNAGPPGGLSLSPATASGKCKDSVQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSP6</accession>
    <name>A0A182PSP6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PSP6"/>
    <dbReference type="STRING" id="199890.A0A182PSP6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009982-RA">
        <property type="protein sequence ID" value="AEPI009982-PA"/>
        <property type="gene ID" value="AEPI009982"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009982"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034243">
        <property type="term" value="P:regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20159">
        <property type="entry name" value="PWWP_BS69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057053">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047268">
        <property type="entry name" value="PWWP_BS69"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047269">
        <property type="entry name" value="ZMY11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24324">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="354"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="9">
        <location>
            <begin position="444"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="10">
        <location>
            <begin position="761"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009982-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="816" mass="92994" checksum="C0C12B5DFCB42337" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PST8</accession>
    <name>A0A182PST8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PST8"/>
    <dbReference type="STRING" id="199890.A0A182PST8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010024-RA">
        <property type="protein sequence ID" value="AEPI010024-PA"/>
        <property type="gene ID" value="AEPI010024"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010024"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010024-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="71" mass="8435" checksum="EE66A71315CFC009" modified="2016-09-07" version="1">MDCYFRQSWVDRRLAFSGAQDTLALSISMLGRIWKPDTYFYNGKQSYLHTITTPNKFVRLYQDGRVLYSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU68</accession>
    <name>A0A182PU68_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neuronal cell adhesion molecule</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PU68"/>
    <dbReference type="STRING" id="199890.A0A182PU68"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010504-RA">
        <property type="protein sequence ID" value="AEPI010504-PA"/>
        <property type="gene ID" value="AEPI010504"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010504"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002166">
        <property type="entry name" value="Protein borderless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001453">
        <property type="entry name" value="Turtle, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001149">
        <property type="entry name" value="Turtle, isoform H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001842">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="83"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="179"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="274"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="367"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="481"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010504-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="70912" checksum="0F8E0A82516EF562" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUU2</accession>
    <name>A0A182PUU2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUU2"/>
    <dbReference type="STRING" id="199890.A0A182PUU2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010729-RA">
        <property type="protein sequence ID" value="AEPI010729-PA"/>
        <property type="gene ID" value="AEPI010729"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010729"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010729-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="699" mass="81038" checksum="85E1DCBB1C1AD4C5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUX2</accession>
    <name>A0A182PUX2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUX2"/>
    <dbReference type="STRING" id="199890.A0A182PUX2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010759-RA">
        <property type="protein sequence ID" value="AEPI010759-PA"/>
        <property type="gene ID" value="AEPI010759"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010759"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF24">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 3, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="92"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010759-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="405" mass="46768" checksum="6A147E99069D72BE" modified="2016-09-07" version="1">MASFLSMLKQSTLVHLCFAISFFTSGLIINTVQCILYVGLKPFNKHLYRTIGYYLCYSFYSQLVFLADWWSDTKLNLYISDEDMKYCGTEHVLLLMNHTYEIDWLIGWMFCEKVRVLGNCKAYAKKVIQYIPTIGWAWKFAEFVFLERSFEKDREIIGRQINEILDYPDPVWLLLNAEGTRFTEQKHEASVKFALEKGMVPLKHHLIPRTKGFTASLPFLREKCPAVLDIQLAISKDSKVKPTIFNILNGKQIEAHLCVRRYPTNTLPEREEEAAVWLQDLFREKDRMQDSFHRTGSFFTDSGVADRPRVHLHRRPTTLVNTAFWVVATLTPMLYYLVKLLFSGEILYFSIGAGIIFAFYMLMVKAIGMSKISKASSYGAVKQNNGHSPTHEPSAPAMEELPKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV79</accession>
    <name>A0A182PV79_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A182PV79"/>
    <dbReference type="STRING" id="199890.A0A182PV79"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010866-RA">
        <property type="protein sequence ID" value="AEPI010866-PA"/>
        <property type="gene ID" value="AEPI010866"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010866"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000040">
        <property type="entry name" value="Putative ribosomal RNA methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010866-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="307" mass="34419" checksum="C9D8063F7B37ACF8" modified="2016-09-07" version="1">MGKTSKDKRDIYYRLAKEEGWRARSAFKLIHIDEVFHIFDGVTRAVDLCAAPGSWSQVLSKRLYESRDPAEREEVKIIAVDLQTMGPLPGIIQLQGDITKLSTAEAIIEHFGAQQKAQLVICDGAPDVTGLHDIDEYIQSQLLLAALNITTHVLTPGGTFVAKIFRGKDTSLLYSQLRIFFERVTIAKPPSSRNSSIEAFVVCQDYRPPEGYVPQLINPMLDDVQVIACETNAPVNRAIVPFLVCGDLREFDSDMSYSLNIDPEKDYEYRDVVQKPLAPAYSEVLERMKTTSLKHGSIKVEADKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV88</accession>
    <name>A0A182PV88_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transmembrane protein 120 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM120 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PV88"/>
    <dbReference type="STRING" id="199890.A0A182PV88"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010875-RA">
        <property type="protein sequence ID" value="AEPI010875-PA"/>
        <property type="gene ID" value="AEPI010875"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010875"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012926">
        <property type="entry name" value="TMEM120A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21433:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 120 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21433">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07851">
        <property type="entry name" value="TMEM120A-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010875-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="45246" checksum="EC0A07135B5BD796" modified="2016-09-07" version="1">MSLSVDVDELEKDWSELSDEYRSLETANQQYQELHERLEEMQEKCTKQIQHQRYRMRQISKNIKTYLAKERLTPEDKEKVTQLEKSIMKRKAQIHEIEQGLPQQNSQYLKIILGDVNVSILNRNDKIRYKDEYEKFKLILNVIGLLLSFLNIVFNYRALELVFLFLLVWYYCTLTIRESILKVNGSRIKGWWRLHHFISTVCAGVLLVWPQGEPWQQFRTQFMYFNVYISLVQYMQFRYQKGVLYRLKALGERHNMDITIEGFHSWMWRGLKFLFPFLFLGYVFQCYNAWTLYGLSQHRDATWQIPVLAFLFMILFVGNSLTTLMVILQKQTERTENRYRLMSLIASKRQKTVRQPTNDGAEGGSSANKGDPSTDTEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV93</accession>
    <name>A0A182PV93_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PV93"/>
    <dbReference type="STRING" id="199890.A0A182PV93"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010880-RA">
        <property type="protein sequence ID" value="AEPI010880-PA"/>
        <property type="gene ID" value="AEPI010880"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010880"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12337">
        <property type="entry name" value="RRM1_SRSF4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000420">
        <property type="entry name" value="serine-arginine protein 55 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010880-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="253" mass="29591" checksum="18BF08192C28A9B2" modified="2016-09-07" version="1">MVGSRVYVGGLPYGVRERDLERFFKGYGRTRDILIKNGYGFVEFEDYRDADDAVYELNGKELLGERVVVEPARGTARGPSGYRERDRYDRDRRGGRYDKYKSNSRNSSRYGPPLRTEYRLVVENLSTRVSWQDLKDYMRQAGEVTYADAHKQRKNEGKSRDNSKSKSRSRSPKRDRDESRSRSRSRSKSHSRSRSKSKDNKSRSRSRSRSRSPRSHSRSRDRSQSQDKSHDKSRSASPKNNDHSPERNESMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX38</accession>
    <name>A0A182PX38_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX38"/>
    <dbReference type="STRING" id="199890.A0A182PX38"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011525-RA">
        <property type="protein sequence ID" value="AEPI011525-PA"/>
        <property type="gene ID" value="AEPI011525"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011525"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011525-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="190" mass="21600" checksum="B9DDC565B7290611" modified="2016-09-07" version="1">MYRLRTVTYGEAASSYLACRALYEAGEEVRSSQPEVADVIQQSFYVDNLSMGAATSEELRVLRAGVERALMRRGMPLRKWASNVPDVIRDVPEEHLDTTVDIGDRQAIKMLGLAWCPTEDTFQLIIDNDLYVPVKSLSKRCLVGRIAKLYDPVGILQPVIVTSKILMQDLWRDNLAWDEDVPLRVIDEWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PXA4</accession>
    <name>A0A182PXA4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PXA4"/>
    <dbReference type="STRING" id="199890.A0A182PXA4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011591-RA">
        <property type="protein sequence ID" value="AEPI011591-PA"/>
        <property type="gene ID" value="AEPI011591"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011591"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011591-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="46457" checksum="00B5FA74EA398CC9" modified="2016-09-07" version="1">SQIAARQPVPRDLPTFSGNVDDWVVFITAFNRTTAACAYTDDENIIRLQHALRGPALEAGGHLLSFPDGLNEAIETLKSRYDPTRRPDLIVESVIRKIRCMAAPKVNDLPSLVEFGFAVKRLVGAVRASGLRAYIYDVTLLKELVRKLPPVLCIDWARTTRGLSEITLMEFGQWIGELANDLCRVVDVSPVPAEPESALQSRYTLPKRQQPHQQPFHARRSQLDRPHHSRPSQMQSHGTGHVHPAYCNATVLQEIEVSDPTTSNNPSRRAFVNERRVCRRCLGYHGGRCRAPPCGVNGCGVHHHELLHSEDATSTCATIRLDCRTGPTGNTSGTQANILTHRDANDGAILKYVPVSLHGPTGRINTYAFLDDGSTSTFIEHELVAELGLSGTPDSRCACSGPGMYEEKKRTPLSCLFVYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PXY3</accession>
    <name>A0A182PXY3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PXY3"/>
    <dbReference type="STRING" id="199890.A0A182PXY3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014201-RA">
        <property type="protein sequence ID" value="AEPI014201-PA"/>
        <property type="gene ID" value="AEPI014201"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014201"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014201-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="450" mass="51639" checksum="44FE7A22AA7A36D0" modified="2016-09-07" version="1">MENSSVHEKATGYELFPDELPDPDSVPSLEVELRKGARERLMNRKLEAQQRRAEKRPSVPTVYKLVHPSPQKYKKCQHSENFILDREVLKPLEHIGFIALPRQVVHQKRPHFVEHKLSSATNRIKTLARPGTAHVKNTLEYYSTQLSSKQQQHLQSYLEPKPFVSIQESIGYARQQRSDDAMWRRHRAKQERKLLHRIHGWEIKLLKQTMHRLSKCLKDFYLYASLEPLEEEAAQISQVVQRRISRLLETSIPRVAPQDSPDGNDVIEDFYVEFSAKVGQWIWRLMKQTGITFDKQKSFSYARKSESFVSVSSSIFQIPCVGATTTVEGELEPLSILSLELVYDCMDDAVLRVEQGSLDRRDSVCMEVAKANSAVDTMQEVVKSQSNESLPETDVGDTIDARASIQEGSQEEDETDIEDQVTVIEKIVNDEAKEEYTNPNTDEEPENDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYL3</accession>
    <name>A0A182PYL3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNMT-activating mini protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RAM family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYL3"/>
    <dbReference type="STRING" id="199890.A0A182PYL3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014409-RA">
        <property type="protein sequence ID" value="AEPI014409-PA"/>
        <property type="gene ID" value="AEPI014409"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014409"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106005">
        <property type="term" value="P:RNA 5'-cap (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028271">
        <property type="entry name" value="RAMAC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48168">
        <property type="entry name" value="RNA GUANINE-7 METHYLTRANSFERASE-ACTIVATING SUBUNIT-LIKE (PSEUDOGENE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48168:SF1">
        <property type="entry name" value="RNA GUANINE-N7 METHYLTRANSFERASE ACTIVATING SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15320">
        <property type="entry name" value="RAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014409-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13606" checksum="D586B45B0BDDF6FF" modified="2016-09-07" version="1">MVDPKRHINILSPEEQAFLEECENEFAHRFTDLDEEFMAHCQRPSKPPPIVQPWNNWRGGGRGGGGRGGRGGVAGWRGERRVNDRSERGGRNHSFHGYRRGYRPYDQPRRDEHAQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYY5</accession>
    <name>A0A182PYY5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYY5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015053-RA">
        <property type="protein sequence ID" value="AEPI015053-PA"/>
        <property type="gene ID" value="AEPI015053"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015053"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF134">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131923" description="Gustatory receptor" evidence="9">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015053-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="394" mass="45413" checksum="EA92EAC930BC4C70" modified="2016-09-07" version="1">MAGLCAKLRVLLFVGTVLSLVPCRYRYKMNRFEAKSCLSLFAFTINISLSSAHMYYDWWQFWSGNRQHSSHILYFFQLVHTVTYPSTVVCVQLVTFSNRVHIAALFNALFTDRSWQFVGDFHTNRWHASSYWLGRFSTAVTVGGMVYIALLISSIYKSIAPFLKYVTILEGLRVYVTLTAIFIYIVCVQVVKMHLKQVQEWIERFGSSVNTPRLWCIFMDQYAAAVGMVQEINRIFSVPLLTILAQVQVQLSFQYLMLYCSTQQRLGSIAYGLMLFHTQCWESMFLLMLLAVGYTCGSCHDQIENVNVAVRSSVATVKGDPSHTRKWINRFLLQTLCQTDQHRFRVGGLFVLDNKFVCMALTSMATYLVILIQFEQYEIANESLMSSNVSYTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PL24</accession>
    <name>A0A240PL24_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine rich immune protein (Coil-less)</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A240PL24"/>
    <dbReference type="STRING" id="199890.A0A240PL24"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015376-RA">
        <property type="protein sequence ID" value="AEPI015376-PA"/>
        <property type="gene ID" value="AEPI015376"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015376"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015376-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31488" checksum="91564B99E6BB9496" modified="2017-10-25" version="1">MLLDLSRNRIHALYGTRAWMEPRYLMLADLYVRENKLKRINMNLFRTMKSLTRLDLSHNQLSVVSGTLVACRLNSVDLSFNRLFELDCCGWEVPVLYGLVANNNHLSTLPRCTEQALIDVYRLTLDKNQLQSDVIFEIRALENLQFLTLSGNKLTHVTLNSSTLPRNLIYLNLSHNNLKVLELPYVPTKDVHIDVSMNCIGEIDWNTMSTNLTKLEMKGNPLDCSFISITAREYVRSKVVCTESIVERCLPKATTKRPLIHKPTVNERRFYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PM24</accession>
    <name>A0A240PM24_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D7 short form salivary protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PM24"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015310-RA">
        <property type="protein sequence ID" value="AEPI015310-PA"/>
        <property type="gene ID" value="AEPI015310"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015310"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000008">
        <property type="entry name" value="D7-related 4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013326179" description="D7 short form salivary protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015310-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18801" checksum="70A3885EF95662AB" modified="2017-10-25" version="1">MEQSGRNISLILVIFSLISVKAGTVNDCVRFVPESARSTVCDVRQYRATKEVDADRYVQCVLTALGFADESGSIQRSNILAALDAVETHDGVYTDSVDACLSRAKKLSSAERSGSFYNCMLRTESAQNFRDAVELQELRLASKWSESERFDRSKVQQLMRELNSQLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PNG4</accession>
    <name>A0A240PNG4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EMI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A240PNG4"/>
    <dbReference type="STRING" id="199890.A0A240PNG4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015383-RA">
        <property type="protein sequence ID" value="AEPI015383-PA"/>
        <property type="gene ID" value="AEPI015383"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015383"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07546">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EMI" evidence="3">
        <location>
            <begin position="34"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015383-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="92" mass="10786" checksum="5913FE85E799FE96" modified="2017-10-25" version="1">MQHHLNYSRLQSCEAVSILLTVFLLISHVYSLRGDNVCYLYESYIETETVPRNQTVQVLTRQWCLEIPPRCTSYRTEIKEVFVKQVSSITDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P062</accession>
    <name>A0A182P062_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P062"/>
    <dbReference type="STRING" id="199890.A0A182P062"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000294-RA">
        <property type="protein sequence ID" value="AEPI000294-PA"/>
        <property type="gene ID" value="AEPI000294"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000294"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF230">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="95"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000294-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="308" mass="34751" checksum="65E83C3968EDB391" modified="2016-09-07" version="1">MSLIQPSGELSAKIKEELREPANPADIERDIGIIREWLSKQPHLPKDMDDARLRTFLRGCKFSLERVKQKLDMYYTMRNAVPEFFTDRDVSRPEMAEVLNVIHMPPLPGLTPNGCRVVMLRGTDKDIATPNVIESMKATLMIGDIRLAEESVGVAGDVYVLDASVATPTHFAKFTPALVKKFLICVQEAYPVKLKEVHVINVSPIVDTIVNFVKPFLKEKIRERIHIHSNIEDLYKYVPKAMLPSEYGGDAGSCKELNDAWRAKMGEYTAWFKEQEASKANESLRPGAPKTADELFGMDGTFRQLTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0H8</accession>
    <name>A0A182P0H8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0H8"/>
    <dbReference type="STRING" id="199890.A0A182P0H8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000410-RA">
        <property type="protein sequence ID" value="AEPI000410-PA"/>
        <property type="gene ID" value="AEPI000410"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000410"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04317">
        <property type="entry name" value="EcAspRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047089">
        <property type="entry name" value="Asp-tRNA-ligase_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="GAD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="179"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000410-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="630" mass="71694" checksum="EE4D09813F88D21F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0I1</accession>
    <name>A0A182P0I1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0I1"/>
    <dbReference type="STRING" id="199890.A0A182P0I1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000413-RA">
        <property type="protein sequence ID" value="AEPI000413-PA"/>
        <property type="gene ID" value="AEPI000413"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000413"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617:SF99">
        <property type="entry name" value="CHAOPTIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130773" description="LRRCT domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="774"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="847"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="429"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="484"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000413-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1034" mass="112245" checksum="AF36D5789A3C9EDD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0M4</accession>
    <name>A0A182P0M4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor AP-2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0M4"/>
    <dbReference type="STRING" id="199890.A0A182P0M4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000456-RA">
        <property type="protein sequence ID" value="AEPI000456-PA"/>
        <property type="gene ID" value="AEPI000456"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000456"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF17">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="243"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000456-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="467" mass="51174" checksum="AFE476E029F00359" modified="2016-09-07" version="1">NLICSFNHYCHSLFLSPQERLTSHGGIGLSSGSPAYSAHTGGHTGRNGPASGHSGSHGGSHGPGPTMHHQTLQSDFQPPYFPPPFHHTTQSPPQQQNHGLDYLSTDPYGQPLSSLHHAPLHHYNQLAGLRPSQEQLGLHRSHRESELQQHVTQLSHGFPYSDRRSDYSGSIGSGAGATRLGAHEHDPLALHQALQSAVDDGQNPVIDENAGFMSDLPLLKNFPITDIKKDSSQINLGSPSDVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEAIHLARDFGYVCETEFPARQVAEYLSRQYSEPQESYRRKELLLNTKQVTKELMDLLNQDRSPLCNTRPQHILDPSIQRHLTHFSLISHGFGSPAIVAALTAIQNYLNESIKHLDKMYPGNGGSMVTSSLDKNKMESDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P117</accession>
    <name>A0A182P117_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P117"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000599-RA">
        <property type="protein sequence ID" value="AEPI000599-PA"/>
        <property type="gene ID" value="AEPI000599"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000599"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130625" evidence="1">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000599-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="141" mass="13545" checksum="F5ADFBDBBAAF9896" modified="2016-09-07" version="1">MCKILLVLSFSAVVLYAQAAPAYQEDPVQSIVPAGESGQPVVIVEDASNGDNDLEGAEAAHFGYGGHGGGFGGGYGGGFGHGGGFGGGFGFKKFGFGGGGFGHRGFGGGFPGHGLGGFGGGGGGFVVGGGFIKGGGFYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P144</accession>
    <name>A0A182P144_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P144"/>
    <dbReference type="STRING" id="199890.A0A182P144"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000626-RA">
        <property type="protein sequence ID" value="AEPI000626-PA"/>
        <property type="gene ID" value="AEPI000626"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000626"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130659" evidence="3">
        <location>
            <begin position="17"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000626-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="603" mass="63584" checksum="0FF8605609E1496B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1D7</accession>
    <name>A0A182P1D7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNase_PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1D7"/>
    <dbReference type="STRING" id="199890.A0A182P1D7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000719-RA">
        <property type="protein sequence ID" value="AEPI000719-PA"/>
        <property type="gene ID" value="AEPI000719"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000719"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000028">
        <property type="entry name" value="exosome complex component RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000719-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="246" mass="26932" checksum="91C68A124C08682E" modified="2016-09-07" version="1">MELLSDQGLRLDGRRANELRQIHCKMGVFSQPDGSAYVEQGNTKVLAAVYGPHQASSKKSNYEEVIVNCQYSMATFSTGERKKRPRGDRKSQEMTIHLKQALSASIKTELYPRSQIDVYIEVLQADGGNYCASVNAATLALIDAGICLKEYVCACTASLANGNVPLMDVSHLEETSGGPTLTVASLPSSGKIAFMEMSQRFHLDHLPKVLETALKGCREVQNVIDRTVREHVTYLGQAGGWGNVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2F7</accession>
    <name>A0A182P2F7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BCL2/adenovirus E1B 19 kDa protein-interacting protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NIP3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2F7"/>
    <dbReference type="STRING" id="199890.A0A182P2F7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001091-RA">
        <property type="protein sequence ID" value="AEPI001091-PA"/>
        <property type="gene ID" value="AEPI001091"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001091"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097345">
        <property type="term" value="P:mitochondrial outer membrane permeabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010548">
        <property type="entry name" value="BNIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15186:SF5">
        <property type="entry name" value="BNIP3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15186">
        <property type="entry name" value="RE48077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06553">
        <property type="entry name" value="BNIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001091-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24998" checksum="97070EE0AB7DE690" modified="2016-09-07" version="1">MNMESWIELSSNTNTSGAGMAGSVTPAGAIGIGSNNLVPTGPTLLTGAVGTKSPDRTTPLAFASVEEYIRLLREAQREESKESSRVASLTSTRKNSPRGSPKSPPNSPNTELAATEEDLRNVYINYVNKDGDIVKDTDWVWDWSSRPDQQPPKDWKFEHPNQTEEERNKPIHAGYSIRQVRVGKNSLFSREFLYSIVLTNVLSLLLGAGIGAWLQKRGLLLTRVSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2H1</accession>
    <name>A0A182P2H1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2H1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001105-RA">
        <property type="protein sequence ID" value="AEPI001105-PA"/>
        <property type="gene ID" value="AEPI001105"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001105"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120013">
        <property type="term" value="F:lipid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="1">
        <location>
            <begin position="516"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001105-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="696" mass="78519" checksum="E7FC833AC1D6A276" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3P8</accession>
    <name>A0A182P3P8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3P8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001533-RA">
        <property type="protein sequence ID" value="AEPI001533-PA"/>
        <property type="gene ID" value="AEPI001533"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001533"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001533-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="102" mass="11786" checksum="F2E9CEAF1A52D2B6" modified="2016-09-07" version="1">MGGVDASRWKPRRAKGTVIYKTRNQFAWAVIAAGTAIFATYYTVVSYVGGDDLKKRLRRDFSEKTEEEVDRRNLMRFSLVAPKRGDTIRRLLDEEKDDQAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3U0</accession>
    <name>A0A182P3U0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-dependent kinase 7</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cell division protein kinase 7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P3U0"/>
    <dbReference type="STRING" id="199890.A0A182P3U0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001576-RA">
        <property type="protein sequence ID" value="AEPI001576-PA"/>
        <property type="gene ID" value="AEPI001576"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001576"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.200.20:FF:000190">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
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        <property type="entry name" value="CDK7"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
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    </dbReference>
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        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="10"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="16"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="20">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013901"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00048367"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
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    </evidence>
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    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001576-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="342" mass="38894" checksum="7F8F207A36FDE6F6" modified="2023-06-28" version="2">MEILNRLNRYEKIDFLGEGQFATVYKARDAETNEIVAVKKIKIGNREEAADGINRTALREIKLLHELHHENIIGLLDVFGHKSNVSLVFDFMDTDLEIIIKDPKIILTPPNIKSYMIQTLRGLEYLHQHWILHRDLKPNNLLISGTGVLKIGDFGLAKFFGSPNRINTNQVVTRWYRCPELLFGARQYGIGVDIWAVGCILAELLLRVPFLPGESDLDQLTRIFQVLGTPNETNWPDVKSLPDYVQYKFYPPIPLRDIFTAASDDLIELANKLLALYPLHRCSCTEALKMAYFSNKPAPTVGPRLPMPASYNAANRQEEKPSLKRKLLDSIDGGTVPKRLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3U2</accession>
    <name>A0A182P3U2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P3U2"/>
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        <property type="protein sequence ID" value="AEPI001578-PA"/>
        <property type="gene ID" value="AEPI001578"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001578"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000209">
        <property type="entry name" value="Tetratricopeptide repeat domain 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000416">
        <property type="entry name" value="Tetratricopeptide repeat protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000792">
        <property type="entry name" value="tetratricopeptide repeat protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000979">
        <property type="entry name" value="tetratricopeptide repeat protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001545">
        <property type="entry name" value="tetratricopeptide repeat protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001760">
        <property type="entry name" value="tetratricopeptide repeat protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
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    <dbReference type="InterPro" id="IPR058900">
        <property type="entry name" value="TTC28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26117">
        <property type="entry name" value="TTC28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="417"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="737"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="4">
        <location>
            <begin position="1437"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="domain" description="TTC28 C-terminal" evidence="5">
        <location>
            <begin position="1838"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1946"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2215"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2301"/>
            <end position="2324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2369"/>
            <end position="2423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2523"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2591"/>
            <end position="2614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2740"/>
            <end position="2873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="830"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1967"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2016"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
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            <begin position="2221"/>
            <end position="2231"/>
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    </feature>
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        <location>
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            <end position="2412"/>
        </location>
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        <location>
            <begin position="2523"/>
            <end position="2532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2533"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="2593"/>
            <end position="2609"/>
        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2770"/>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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            <end position="2866"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001578-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2873" mass="308867" checksum="D9553338341E1748" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P406</accession>
    <name>A0A182P406_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P406"/>
    <dbReference type="STRING" id="199890.A0A182P406"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001642-RA">
        <property type="protein sequence ID" value="AEPI001642-PA"/>
        <property type="gene ID" value="AEPI001642"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001642"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04670">
        <property type="entry name" value="NUDIX_ASFGF2_Nudt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000016">
        <property type="entry name" value="nudix hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000015">
        <property type="entry name" value="Nudix hydrolase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003293">
        <property type="entry name" value="Nudix_hydrolase6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040618">
        <property type="entry name" value="Pre-Nudix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994:SF13">
        <property type="entry name" value="FI03680P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994">
        <property type="entry name" value="NUDIX HYDROLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18290">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01356">
        <property type="entry name" value="GFGPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="153"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001642-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="334" mass="37708" checksum="8F7E4D90DCC2F392" modified="2016-09-07" version="1">MSRALLVIPQRLLSIVRCNQVSLITRHSSKMSEQQESNIVKGADSWFNKYTAVESSPEGTFKGVKDRFNGITVDSSMETCSPDAFPAVLKRSLDHWIQSKNRGIWFKVHLSAASWIPELVDNGFQFHHAKNSFVMLYRWLPTEESANIPPYSHTMVGVGALVMNERNQVLVVSENYALIAGSWKLPGGYVEPNENFVDAAIREVEEETNIRTKFDSVVSIRHAHGAGFGCSDLYIVMALTPLSEEITKCNREIAKCEWMDVNKYLNHPKVHETNRNFVRTYLEYKRLGVRIDCTEEMHQVLKKRYNIYSVAKVGSVPGSVDSSDSGTISSTPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P432</accession>
    <name>A0A182P432_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Electron transfer flavoprotein subunit alpha</fullName>
            <shortName evidence="7">Alpha-ETF</shortName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7 8">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P432"/>
    <dbReference type="STRING" id="199890.A0A182P432"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001668-RA">
        <property type="protein sequence ID" value="AEPI001668-PA"/>
        <property type="gene ID" value="AEPI001668"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001668"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045251">
        <property type="term" value="C:electron transfer flavoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="281"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001668-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="332" mass="34584" checksum="708D055BAF45B2EF" modified="2016-09-07" version="1">MFARCSSSLVRPSAQGFRRFQSTLVVAEHNNETLNPITANAVTAAKKLGGDVTVLVAGTKVGPVSEAAAKLDGVKKVLVAEGDAYKGLLAESLTPLILATQEQHKFTHIVAGATAFGKAVLPRIAAKLDVSPVSDIIGVQSADTFVRTIYAGNAIQTVKSKDAVKVITVRGTNFEPTGAAGSAAAIEKAPEGDFVSKTTEFVSQELTKSDRPSLTAAKIIVSGGRGMKSGDNFKMLYDLADKWGAAVGASRAAVDAGYVPNDLQIGQTGKIVAPELYVAIGISGAIQHLAGMKDSKTIVAINKDAEAPIFQVADYGLVADLFKVVPEINEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P440</accession>
    <name>A0A182P440_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chorion peroxidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P440"/>
    <dbReference type="STRING" id="199890.A0A182P440"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001676-RA">
        <property type="protein sequence ID" value="AEPI001676-PA"/>
        <property type="gene ID" value="AEPI001676"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001676"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000003">
        <property type="entry name" value="chorion peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130935" description="Chorion peroxidase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001676-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="85667" checksum="8D7B05E5758444A3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4D6</accession>
    <name>A0A182P4D6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD23 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4D6"/>
    <dbReference type="STRING" id="199890.A0A182P4D6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001772-RA">
        <property type="protein sequence ID" value="AEPI001772-PA"/>
        <property type="gene ID" value="AEPI001772"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001772"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000254">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="340"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001772-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="386" mass="41568" checksum="D8E3970EDFA3F75E" modified="2016-09-07" version="1">MKITLKTLKQQTFFVEVDVEKDTVRTLKEKLHAESGLAYPVDRQRLIYLGKIMEDDHPLSQYKLDDKKFIVVMSKKLPAADEQPAEEKEQQGASKPADGKTDTKSAGAAEPAAASAGKPSTSSSSSTATTAPAVAPSTGSDQKTAASTADSNPTTTNTTTATTNPSTEAVPEEMRINIQRLKEMGYSEQSARLALEICANIPDRAVEYLLSEMGGGSDMSLALAAQQQQQQQQQQAGTAGGAAQSGGANPLAFLRDNPVFEDMRRILRDDPSMLPYLMRRMQASNPELLNIIAEYQDEFLALINEGNQGQGGGGGVGSAGQPLSRELEDIAAAMVNSLTPSDMDAIERLKALGYPEHLVIQAYIACERDEYDAAMFLVTQTLDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4W9</accession>
    <name>A0A182P4W9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chemosensory protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4W9"/>
    <dbReference type="STRING" id="199890.A0A182P4W9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001956-RA">
        <property type="protein sequence ID" value="AEPI001956-PA"/>
        <property type="gene ID" value="AEPI001956"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001956"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF9">
        <property type="entry name" value="CHEMOSENSORY PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001956-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17174" checksum="2D8F1C481D4FBF84" modified="2016-09-07" version="1">MNTRSARATSILPEALRTKCARCSPIQKENALKIITRLYYDYPDQYRALRERWDPSGEYHRRFEEYLRGLQFNQIGGNGAPTGGSGVGNTVESGGNDRPAGNQPLPPSPIVGLWNQLGTKIADTADAIAGMLKKTVDVLVTSHIQSHQRALRRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P529</accession>
    <name>A0A182P529_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P529"/>
    <dbReference type="STRING" id="199890.A0A182P529"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002016-RA">
        <property type="protein sequence ID" value="AEPI002016-PA"/>
        <property type="gene ID" value="AEPI002016"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002016"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002016-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="87" mass="9553" checksum="BD968015B5C667EB" modified="2016-09-07" version="1">MQPNLANKRLSICGWKKSGSEKSKLVPWDLIDRMVAPIICCHAAAILLSGALNLLRISQVSALVLFILFTILTVSGVLFYHSLTSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P570</accession>
    <name>A0A182P570_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P570"/>
    <dbReference type="STRING" id="199890.A0A182P570"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002058-RA">
        <property type="protein sequence ID" value="AEPI002058-PA"/>
        <property type="gene ID" value="AEPI002058"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002058"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="139"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="510"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002058-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="83784" checksum="156EDCF08BE31646" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P652</accession>
    <name>A0A182P652_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P652"/>
    <dbReference type="STRING" id="199890.A0A182P652"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002400-RA">
        <property type="protein sequence ID" value="AEPI002400-PA"/>
        <property type="gene ID" value="AEPI002400"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002400"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002400-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="300" mass="33228" checksum="10C0A04FE5D3F5A4" modified="2016-09-07" version="1">MSSHHHHLHHVHHQHDNIMSEVEVPDANIVEVVDGSAAFGTEIDYDQYGGVDGHFEEVTCETEDSQGLMGHHHHLGHHGDDDEEILHHEPDIEQAVHEEVLDSSGDAMCVYGDINLENEIYIESATTTPPGPSSRKRKSLKQSRSGGGMMSRIRGNDGSVLHHHHHGLTAVEQMDVNHKRRRWEQKQVQIKTMEGEFSVTMWASGTDDDDGSNPEIDPDYTEYMTGKKITPDGCDTIPGIDLSDPKQLSEFTRPAHKSKSGSGKLSSSSSTSSNALLSAFVKMESVEIDNDASQYVIYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6G3</accession>
    <name>A0A182P6G3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6G3"/>
    <dbReference type="STRING" id="199890.A0A182P6G3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002511-RA">
        <property type="protein sequence ID" value="AEPI002511-PA"/>
        <property type="gene ID" value="AEPI002511"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002511"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032924">
        <property type="term" value="P:activin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF25">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MH1" evidence="5">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002511-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="67" mass="7695" checksum="9F7FA8D8277B8A5A" modified="2016-09-07" version="1">MLPFTPPIVKRLLGWRKVDEATEIEKKWSEKAVKSLAKKMKKSSALEELERALTAQSCRTKCIPIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7S6</accession>
    <name>A0A182P7S6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7S6"/>
    <dbReference type="STRING" id="199890.A0A182P7S6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002979-RA">
        <property type="protein sequence ID" value="AEPI002979-PA"/>
        <property type="gene ID" value="AEPI002979"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002979"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002979-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="446" mass="50549" checksum="EE3821480EEE5A71" modified="2016-09-07" version="1">MVSVAKVRHKLWHLITALCHSPKRLVRGIVLFICSIVVMYQLTDCFKKLCNPPISTHSRFDLNDTMLYPAITFCREPAYKADVMAKYNLAMHPKYTSSFDRFPFNQSSLEQLFNEATYNHSEFFIQHGLNGDIKNIEVVESLHLDMGRCYTLNPLTKTKHSWKEAGYSIMLRHDTNISQVSVGDTPPGWHVFIHDETEGFAENRMQSSGRVEYLYLEANEEMEIRLSTQHFFMLASYENECVEFSTVSSTRCGEICHWNAVVDTVGCSGPWMPGLGVRDCDNAESTQQLIKLYRQLEDLDGTQCGCFQPCTTTIFTAAVMNRKPFHISVPAAQLWVYYTSKMVTIVEEFHGYDFNQFVSDLGGSLGFLLGLSVLGLIGLLEKIVELVFIRRLLSEKRKKEAEQKEAVSNDPVAMKAAEQPNTTKHVNMDEGKLTDKAVADGAILTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7X0</accession>
    <name>A0A182P7X0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein white</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7X0"/>
    <dbReference type="STRING" id="199890.A0A182P7X0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003023-RA">
        <property type="protein sequence ID" value="AEPI003023-PA"/>
        <property type="gene ID" value="AEPI003023"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003023"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031409">
        <property type="term" value="F:pigment binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001225">
        <property type="entry name" value="ATP-binding cassette sub-family G member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005284">
        <property type="entry name" value="Pigment_permease/Abcg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00955">
        <property type="entry name" value="3a01204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF129">
        <property type="entry name" value="PROTEIN WHITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0608">Pigment</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="585"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="96"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003023-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="696" mass="77300" checksum="8FFF10AEDABDB85C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7Z0</accession>
    <name>A0A182P7Z0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7Z0"/>
    <dbReference type="STRING" id="199890.A0A182P7Z0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003043-RA">
        <property type="protein sequence ID" value="AEPI003043-PA"/>
        <property type="gene ID" value="AEPI003043"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003043"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003043-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="297" mass="34243" checksum="56114462E95F055D" modified="2016-09-07" version="1">MDSGFESSSRDQQSDETLALRRTAGMDAYEATGSSEDPEVRQAFSDSILHILRPLSVLELPGAGSRCDNGSESTGSALSEPFSDLDDSYILLDQRKKKPGKDEGDDMMLLNQFTSEFREVYDQLIAESDEKEEPILPPDSGPEQDFTREMFLEDASGFSPPFQSYIDEMLLKCGLKYHLDERKRQRDQHRRKHRRVRKSHPAVPKDALDPAERDSLSGVWRMLDAVSEPNGFPITEGQYDLYEDERFEWLLREKMPWHRMEVSRKKCEQWLKIGASKAKGQDEQRSRLSHHRPSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9K3</accession>
    <name>A0A182P9K3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="4 13">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="4 13"/>
    <dbReference type="AlphaFoldDB" id="A0A182P9K3"/>
    <dbReference type="STRING" id="199890.A0A182P9K3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003608-RA">
        <property type="protein sequence ID" value="AEPI003608-PA"/>
        <property type="gene ID" value="AEPI003608"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003608"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003608-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="368" mass="42277" checksum="B3113ABE94018160" modified="2016-09-07" version="1">MTIMLCYEGRVSLYCFLGGMASLLVFYGAEAFLHEESVWTKVALSVGYYISLNVIIRIRYNPRDYQIAVRAAFLGTVLSAGIVVFLYAQDQYKSFGIYATLMALFHYTEYLGIAICNPKTLSPDSFILNHSVHYALAAAASWIEYFVEVHYFPEMKTYKSVWTAGLLLCLAGESLRKVAMITASKNFSHIVQFERHNEHELVTHGVYGWMRHPSYVGWFYWSIGTQITLANPVCFVIYAIASWKFFHDRILMEEITLLNFFGEEYIQYQERVSSGLPYIRGFRHDPECEDQTGFHTDKNDETDEREGTGTVRRSFEDNNERHVMEMAKVDVDRRRSIGSSGGGIEHSRNRRYSGTYDNCDDQDASSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9R2</accession>
    <name>A0A182P9R2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9R2"/>
    <dbReference type="STRING" id="199890.A0A182P9R2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003666-RA">
        <property type="protein sequence ID" value="AEPI003666-PA"/>
        <property type="gene ID" value="AEPI003666"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003666"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF224">
        <property type="entry name" value="NEPRILYSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="12">
        <location>
            <begin position="115"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="11">
        <location>
            <begin position="568"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003666-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="774" mass="88396" checksum="9303386CA3EE0B1C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9Z5</accession>
    <name>A0A182P9Z5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P9Z5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003749-RA">
        <property type="protein sequence ID" value="AEPI003749-PA"/>
        <property type="gene ID" value="AEPI003749"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003749"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000059">
        <property type="entry name" value="PAS domain containing serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003749-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1435" mass="156274" checksum="825C3231AC30A7B1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA43</accession>
    <name>A0A182PA43_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitogen-activated protein kinase kinase kinase 4</fullName>
            <ecNumber evidence="4">2.7.11.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">MAPK/ERK kinase kinase 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="4"/>
    <dbReference type="STRING" id="199890.A0A182PA43"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003797-RA">
        <property type="protein sequence ID" value="AEPI003797-PA"/>
        <property type="gene ID" value="AEPI003797"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003797"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000122">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045801">
        <property type="entry name" value="MEKK4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19431">
        <property type="entry name" value="MEKK4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="1304"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="492"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1148"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1160"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003797-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1591" mass="178522" checksum="DFB114A578984980" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB07</accession>
    <name>A0A182PB07_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">formyltetrahydrofolate dehydrogenase</fullName>
            <ecNumber evidence="4">1.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="1.5.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:10181"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.6" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PB07"/>
    <dbReference type="STRING" id="199890.A0A182PB07"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004112-RA">
        <property type="protein sequence ID" value="AEPI004112-PA"/>
        <property type="gene ID" value="AEPI004112"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004112"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016155">
        <property type="term" value="F:formyltetrahydrofolate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009258">
        <property type="term" value="P:10-formyltetrahydrofolate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000002">
        <property type="entry name" value="10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000002">
        <property type="entry name" value="10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="entry name" value="Formyl transferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011407">
        <property type="entry name" value="10_FTHF_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036489">
        <property type="entry name" value="10-FTHFDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="17">
        <location>
            <begin position="351"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="740"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>(6R)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>(6R)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="630"/>
            <end position="633"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="663"/>
            <end position="668"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="683"/>
            <end position="684"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="790"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="838"/>
            <end position="840"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="14">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004112-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="936" mass="102632" checksum="B826B57385295BE3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB58</accession>
    <name>A0A182PB58_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PB58"/>
    <dbReference type="STRING" id="199890.A0A182PB58"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004163-RA">
        <property type="protein sequence ID" value="AEPI004163-PA"/>
        <property type="gene ID" value="AEPI004163"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004163"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="257"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="319"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004163-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="510" mass="58182" checksum="C1CA342A9328686B" modified="2016-09-07" version="1">MEYINNVSGGGISASSGAVNKILCCECGVPIEPNATNMCVPCLRSHVDITENIPKQAVIFFCRNCERYLNPPNEWVQCSLESKELLSLCLKRLQGLRQVKLVDAGFVWTEPHSKRIKVKLTVHGEVMSDVVLQQVFVVEFTVNNQMCDDCHRTEAKDFWRCMVQVRQKAVNRKTLFYLEQMILKHKAHENTLGIKPNTGGLDFFYATDAHARKMVDFLQAVLPVKVTNSKKLISHDIHSNSYNYKYSYAVDIVPVSKGSLVCLNKRLTQQLGHIAPVCLVSKVANSIHLIDPQTAQMAEVQNMAYWKSPFEAICNPKQMVEFVVMDVEIIREHERKTFPGQGPVSHRHTLADVWVVKSAELGINENTIHVKSHLGNLLKPGDYVLGYDLREANVNNADYEKLKSETVPDVLLIKKSYDKTVRKQNRNWKLKHLNEDVAVDTDIENEYNEFLEDLEEDPELRQNVNIFKDKNKQQIPVDTNDMDDPSVPRITLEEMLDDLVLEDEEMGDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBS1</accession>
    <name>A0A182PBS1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase</fullName>
            <ecNumber evidence="9">3.5.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartylglucosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycosylasparaginase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15947"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58080"/>
            <dbReference type="EC" id="3.5.1.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.26" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A182PBS1"/>
    <dbReference type="STRING" id="199890.A0A182PBS1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004377-RA">
        <property type="protein sequence ID" value="AEPI004377-PA"/>
        <property type="gene ID" value="AEPI004377"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004377"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003948">
        <property type="term" value="F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04513">
        <property type="entry name" value="Glycosylasparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000003">
        <property type="entry name" value="N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF6">
        <property type="entry name" value="N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131072" description="N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase" evidence="16">
        <location>
            <begin position="24"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="243"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="266"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="15">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004377-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="353" mass="37621" checksum="5844380DE56C787A" modified="2016-09-07" version="1">MLRLKIVCWSAVICLAILGNANGGLPLVATTWRFTNATLRAYQSLTVGQFDPIEALVEGCSVCEREQCDGTVGFGGSPDENGETTLDAMLMDGKTMDIGAVAALRDVKHAAEVAKYVLRNTKHTLLVGSQATEFAVMMGFKKESLQTEASKSMWSAWKKTHCQPNFWKNVIPSPSMSCGPYEPVSANSIQSGAESAWERSSDRSAYDFGQYNHDTISMIVINEEGHVVAGTSTNGARHKIPGRVGDSPIPGAGAYADSEVGAAVATGDGDVMMRFLPSLLAVEAMRSGVEPEEAGRQAIGRIAKYYPSFVGGIVVVTKDGRYGAACHGMNEFPYSVADGTEANGTVRVLTVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBV9</accession>
    <name>A0A182PBV9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBV9"/>
    <dbReference type="STRING" id="199890.A0A182PBV9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004415-RA">
        <property type="protein sequence ID" value="AEPI004415-PA"/>
        <property type="gene ID" value="AEPI004415"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004415"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000002">
        <property type="entry name" value="AGAP000641-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000003">
        <property type="entry name" value="AGAP010409-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF46">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 99A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131139" evidence="6">
        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004415-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="348" mass="39381" checksum="92A0D1DA57DBD841" modified="2016-09-07" version="1">MRPRSSGTMLLAAIALCLAGCDGTVDVPHLTLAKSFSRALQDCMEYLQVPGYRYAEYAGNSFPDDPETKCLLRCVGLNLRWWNDTTGVQAAVIEGFFHPDPVDEQYDNRTSECLRNELTHGDTSDCCCLAYESFRCYLKNYGNLVPCAQFFPEDESRYVRAAQDCIEFLQTPVKLLKSYSAGHFPDAPETRCLLRCFFLRTGVFYVDTGFDVERLYTRDYEHPDDRYLSRETEAKLHKLRGSMGDQCTEVYLAYRDVLGHLGKAYFEYDVLKAAAQQVLCEVPIELPATTTTASTTTTSTTTACPSKAEFNYKELNCQNCGRMFISPKGRISCCRCMKSSTPFGKFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCX1</accession>
    <name>A0A182PCX1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein TsetseEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCX1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004776-RA">
        <property type="protein sequence ID" value="AEPI004776-PA"/>
        <property type="gene ID" value="AEPI004776"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004776"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013311904" description="Protein TsetseEP domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004776-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30137" checksum="BE6F3525DD9B68D8" modified="2016-09-07" version="1">MKLLLVLLLASVAWAQRPLSVAVIDKMYEVYPLYRQIQDYVINTVADGRLTSSARINDFHKEIITIKETFIATSIRQEQELMTQISSQPNSVNQQCLSFLRQSTELNMNLAGVSYSNCITDAGDTLVSTVQSFYALLDADEARYVGVGLFEEFRDENVFFDPQRIISKLENRMFRLEDYPTHVGSEMLDAVAGLTNSLEGIRLNYINCMTLGEQMLRSAMQLGMLQLEQVCNGKLVTIVEEQPVPPVPEPATPEPATPEPETPEPDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCY4</accession>
    <name>A0A182PCY4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BEACH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PCY4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004789-RA">
        <property type="protein sequence ID" value="AEPI004789-PA"/>
        <property type="gene ID" value="AEPI004789"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004789"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000003">
        <property type="entry name" value="WD repeat-containing protein 81 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866:SF1">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="382"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1855"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1210"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1327"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1374"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1210"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1382"/>
            <end position="1391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004789-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2151" mass="237973" checksum="5C25077980D7376F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDG0</accession>
    <name>A0A182PDG0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDG0"/>
    <dbReference type="STRING" id="199890.A0A182PDG0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004965-RA">
        <property type="protein sequence ID" value="AEPI004965-PA"/>
        <property type="gene ID" value="AEPI004965"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004965"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017248">
        <property type="entry name" value="HAX-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14938">
        <property type="entry name" value="HCLS1-ASSOCIATED PROTEIN X-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14938:SF2">
        <property type="entry name" value="HCLS1-ASSOCIATED PROTEIN X-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004965-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="437" mass="49725" checksum="59A57F2B18038B0D" modified="2016-09-07" version="1">MASRMILSPARRLANVVGTRSITTQVVATRCATIKDEITHTGQYYEENDYRNVRFVNATKVVNPNWAIKLIDELPIVKSEQRVVCCDGGTDPALGHPKVYINLVKTRSSIKICVVKMDLLKKFMGLDGRKDDDDDNRKKKSTLKDEFRKPIWVEEDDSDDELFDNRKIYGVQIFTNPIEMQKYFEQQMQEMWKSLDEYDENVKLFDHDLKQDFLKPGFEEAIRDMDKQVKPQDTDLDGEIYADQLHSLLQRISPDLKELMPKKRSERKKNAGPSMERRKLTDEEKVMDLIHGITEQKNLPNNGTMSKPFRRHGGLPQRFPEGGLFEGAFQGPRMFGQSIISQTIRRPDGSYETRRTVRDSEGNTQTTVTLSTKDGRKETVTTYDEGGKKLGPGEDMFGMKKGNGGGGGDDLPTGALLALDGKFGLNNNGYVLPKNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDH4</accession>
    <name>A0A182PDH4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182PDH4"/>
    <dbReference type="STRING" id="199890.A0A182PDH4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004979-RA">
        <property type="protein sequence ID" value="AEPI004979-PA"/>
        <property type="gene ID" value="AEPI004979"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004979"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983">
        <property type="entry name" value="PROTEIN KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004979-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="706" mass="80545" checksum="16391FDAFA8C5FE5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDP1</accession>
    <name>A0A182PDP1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methylcytosine dioxygenase TET</fullName>
            <ecNumber evidence="11">1.14.11.80</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a 5-formyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + succinate + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53832"/>
            <dbReference type="Rhea" id="RHEA-COMP:13656"/>
            <dbReference type="Rhea" id="RHEA-COMP:13657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:137731"/>
            <dbReference type="ChEBI" id="CHEBI:137732"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 5-hydroxymethyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-formyl-2'-deoxycytidine in DNA + succinate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:53828"/>
            <dbReference type="Rhea" id="RHEA-COMP:13315"/>
            <dbReference type="Rhea" id="RHEA-COMP:13656"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:136731"/>
            <dbReference type="ChEBI" id="CHEBI:137731"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5-methyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:52636"/>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">The zinc ions have a structural role.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TET family.</text>
    </comment>
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        <property type="gene ID" value="AEPI005046"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:chromosomal 5-methylcytosine DNA demethylation pathway"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="entry name" value="TET"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
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        <property type="entry name" value="TET_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23358">
        <property type="entry name" value="METHYLCYTOSINE DIOXYGENASE TET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23358:SF6">
        <property type="entry name" value="METHYLCYTOSINE DIOXYGENASE TET"/>
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    </dbReference>
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        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
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            <begin position="1305"/>
            <end position="2051"/>
        </location>
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            <end position="174"/>
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            <begin position="301"/>
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        <source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005046-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2119" mass="222893" checksum="75BF0771F38F4FA9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEE4</accession>
    <name>A0A182PEE4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
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        <subcellularLocation>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A182PFG2_9DIPT</name>
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            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
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                <person name="Saif S."/>
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                <person name="Wortman J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Epiroticus2</strain>
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            <dbReference type="Proteomes" id="UP000075885"/>
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    <sequence length="178" mass="18374" checksum="9AB186BF63539970" modified="2016-09-07" version="1">MTSEGTLVDLDFGDIITNPASVVVTSNGHAVAAASATPSPPPVIPTIHDTVNQLAFASGANERIPKQQQLPPASGNGERDVNDAIISDLLLPCTSPLFGAATDDKQSVNNQGSSRLSASSASTVATAVVDTGDGTPLVLPDVSFEGITLDSGIDRESQPLLGSRDHEITYNQFPDYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
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            <taxon>Insecta</taxon>
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            <taxon>Diptera</taxon>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">Epiroticus2</strain>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Beta-1,3-glucan-recognition protein, N-terminal domain"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005747-PA"/>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PG30</accession>
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        <recommendedName>
            <fullName evidence="5">Integrator complex subunit 11</fullName>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PG30"/>
    <dbReference type="STRING" id="199890.A0A182PG30"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005889-RA">
        <property type="protein sequence ID" value="AEPI005889-PA"/>
        <property type="gene ID" value="AEPI005889"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005889"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16291">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000002">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000028">
        <property type="entry name" value="Integrator complex subunit 11 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041897">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048662">
        <property type="entry name" value="IntS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21386">
        <property type="entry name" value="IntS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="12">
        <location>
            <begin position="245"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005889-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="607" mass="68781" checksum="4B6908F50BADB80C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PG31</accession>
    <name>A0A182PG31_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PG31"/>
    <dbReference type="STRING" id="199890.A0A182PG31"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005890-RA">
        <property type="protein sequence ID" value="AEPI005890-PA"/>
        <property type="gene ID" value="AEPI005890"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005890"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF397">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131216" evidence="6">
        <location>
            <begin position="31"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="553"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005890-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="603" mass="69201" checksum="E7B0BB4BC70C6B2E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGA0</accession>
    <name>A0A182PGA0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGA0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005959-RA">
        <property type="protein sequence ID" value="AEPI005959-PA"/>
        <property type="gene ID" value="AEPI005959"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005959"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005959-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="127" mass="13402" checksum="3CFC61EE740243C5" modified="2016-09-07" version="1">MPLTIATCLAGVILAQDYQEYRQAPLRIGTKAEEPKPTPVPILKQINRSGYYRKRCFAAVRNNCKLRAGDKIHSKFVPTGAGGRAGVPAAAPPAAGNVIADGARPAAAGYGGAKKFPKPYQTLGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGA4</accession>
    <name>A0A182PGA4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL16m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGA4"/>
    <dbReference type="STRING" id="199890.A0A182PGA4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005963-RA">
        <property type="protein sequence ID" value="AEPI005963-PA"/>
        <property type="gene ID" value="AEPI005963"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005963"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000005">
        <property type="entry name" value="39S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005963-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="242" mass="27886" checksum="7C54FCD2466B7F86" modified="2016-09-07" version="1">MLANCEKLRPLLTGLLRGQFGHPIAGMKFFAPPIKYDSIEIPEKPKLRFMDKVPQLPSNLRAPKMQKKLKWMRGPELVHNSLVHKQYGIVATGGGRLRWGHYEMLRLTIGRKMDTSRMFAIWRVEAPWQPITKQGQGQRMGGGKGAIDHYVTPVKSGRVIVELAGELEFVEAKQILDIVCPKLPFKAMVVSQEMLENMKAEEERLERENLNPWNFKYIIQNNLGGCHRWLSPVDHKWFGKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGH5</accession>
    <name>A0A182PGH5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGH5"/>
    <dbReference type="STRING" id="199890.A0A182PGH5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006034-RA">
        <property type="protein sequence ID" value="AEPI006034-PA"/>
        <property type="gene ID" value="AEPI006034"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006034"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="1">
        <location>
            <begin position="150"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006034-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="305" mass="34883" checksum="6A05F9D9927C9557" modified="2016-09-07" version="1">MERQTKKRAVSAKLNIESVEDYQDEMGSDSDDEMIEFIKVECGTNQDGDPFITNDEVDDNQLFEDGVFEEFNGRKKAHSKKTYKERSKVVREHEVTRDQAGRKPTVPSLGGIEASLMEISNKLDSIGEQFQSILDTVDSKTPKKSSYVDVEFEKIDSLEQLQTFNDELATPEYEEKMRQWLEGNLIDMRSDVRMSDAMDMLFTRKFLTCCSWTGISKGAQKIAMMQMTNVTKLFERIGTTSLAVVNSRRVANFFMKKLKNAGKRALAKGVRKSTSRVTLSSSRLERKCDSHKRDIEKELKHPVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGZ6</accession>
    <name>A0A182PGZ6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5B/HSM3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGZ6"/>
    <dbReference type="STRING" id="199890.A0A182PGZ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006205-RA">
        <property type="protein sequence ID" value="AEPI006205-PA"/>
        <property type="gene ID" value="AEPI006205"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006205"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019538">
        <property type="entry name" value="PSMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554:SF10">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10508">
        <property type="entry name" value="Proteasom_PSMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006205-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="487" mass="55315" checksum="23AD70A9B319CB75" modified="2016-09-07" version="1">MDVSQLEHLMRNLAIKETRTTSLDMLESKLADVRQDIYEVMLSSESLFKFLAEADSDQHTTASRVIYDKALEFFPNGSPVIDRFLERCLTHPKNSVKQFGLRGSAAMVYHSAAISPSTVTLIIQHCLPMKEVYVDTLLNVLIKTLPPMFSEPTVQKHLVSVLQFDETVRCRVYEVVCTVLEKRPDYFPDANAILESALADLDKDDVLLQSNVIQILTQLLATKEGFDYVEKIELFRKVYVNFVSIKITPYARFVLPSALKFLASAAMIQPTLFLQRHPASVDYIFSQTSPEDPMLMAIAYDCLGMVGSTNEGKIFLSENQKEKMEQFLKEFPGALHSTTDAFKVRFIECITSLMSGGSESIDNRITCITQEWYETMAERKDLDMVLSLFINPFPELKMASLKLLSAIVDHRWGQLFFQNTAGFTEQLVNRRLDKLNVNVAQFKYDVIKKLSLCTTLEPYLLEAFGKYVSEGAFHTERQCEVVIEGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH92</accession>
    <name>A0A182PH92_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PH92"/>
    <dbReference type="STRING" id="199890.A0A182PH92"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006301-RA">
        <property type="protein sequence ID" value="AEPI006301-PA"/>
        <property type="gene ID" value="AEPI006301"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006301"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="19"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="295"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006301-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="384" mass="41833" checksum="E2D0B930672D7002" modified="2016-09-07" version="1">MCSTNHRFEIHDKSIMPLSLDLIFNCFSRYRSLRTPANYLVINLAVADFIIMMEAPMFIYNSIHQGPALGSIGCTVYALMGAVGGTVAIATLTVISIDRYNVVVYPLNPNRSTTKLKCYFLIAFTWAYGLLFASFPALEIGLSRYTAEGYLTACSFDYLDRTYKARVFMFVYFVFAWLIPFMIISYCYARILIAVINANAIQSSKSKNKTEVKLAGVVVGIIGLWFAAWTPYAVVAMMGVFGYEQYLTPLNSMIPAVFAKIAASIDPYFYAMNHPRFRQMLERMFCNRGADQGNSQYQTSHYTRGASRAGDSEGGGEESGGGVGRAPGGANAGSMRGTIRGGAGRLITGKGGTTGANAAIGGVKALKKQPSNGDETSLEVSLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHC7</accession>
    <name>A0A182PHC7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial thiamine pyrophosphate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Solute carrier family 25 member 19</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>thiamine phosphate(out) + thiamine diphosphate(in) = thiamine phosphate(in) + thiamine diphosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:73383"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHC7"/>
    <dbReference type="STRING" id="199890.A0A182PHC7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006336-RA">
        <property type="protein sequence ID" value="AEPI006336-PA"/>
        <property type="gene ID" value="AEPI006336"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006336"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="110"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="209"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006336-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="307" mass="34577" checksum="EC1252561698BB78" modified="2016-09-07" version="1">MDREKNDTSSNSGIAGGFAGCITRFICQPLDVLKIRFQLQVEPLSEQHVTSKYRTIAQSTRLVYQEEGLRAFWKGHNPAQVLSIIYGVAQFSSYERFNHLLRTVDTFEKHQSGRNFVCGALSGTFATVITLPLDVVRTRLISQDPGRGYRSSVQGLKLIYTHEGVRGLYRGLGPSVLQIAPLTGGQFMFYNIFGSMFRQYFNISASETLPAIELFICGGLAGLCTKLLVYPLDLAKKRLQIQGFAKSRQTYGRHFVCDNMFNCLYNIAKQEGMIGLYKGLYPALLKACFMSAFYFAIYDEMVLILNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHG2</accession>
    <name>A0A182PHG2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHG2"/>
    <dbReference type="STRING" id="199890.A0A182PHG2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006371-RA">
        <property type="protein sequence ID" value="AEPI006371-PA"/>
        <property type="gene ID" value="AEPI006371"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006371"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006371-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="311" mass="34757" checksum="5CC195303B55300C" modified="2016-09-07" version="1">MDEARMHQNAAAVGRSQPAPNYDQFSPADMKKYYPPGVIPNVPPNVAESSSLQLHFASLAGLDLGKRLGQPDMYFKNPYSTESDEDGSPEAANGMHLATAAAAAAAAAAAAGTGQKTKQPRKRQSTGKRKPKLPKVESPAELALRKFPCPDCPLSFKTGYHLKRHHATIHQDQRFSCTACHTSYGRREKLRAHMELIHKIQSYFVCEICLVSYESEDLLQRHVYRHEHPKPLECPTCLTPNARTSDGNYSGSHICITYQNSYECCGKDFGYHYYYNRHMLTVHNIKTNARVKIPKGTLLSQFRAMRSSRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHH3</accession>
    <name>A0A182PHH3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHH3"/>
    <dbReference type="STRING" id="199890.A0A182PHH3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006382-RA">
        <property type="protein sequence ID" value="AEPI006382-PA"/>
        <property type="gene ID" value="AEPI006382"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006382"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006382-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="769" mass="86409" checksum="8B3666F4A561500B" modified="2019-01-16" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHU1</accession>
    <name>A0A182PHU1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHU1"/>
    <dbReference type="STRING" id="199890.A0A182PHU1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006501-RA">
        <property type="protein sequence ID" value="AEPI006501-PA"/>
        <property type="gene ID" value="AEPI006501"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006501"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006501-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="399" mass="45142" checksum="05DBAE9004077703" modified="2016-09-07" version="1">MGTAEARFTRHRMKLQLHRSCQLYLRFAQLLFNAPYNLAQDVHSNSYFKQARCLVSAGILAWVTICGYRAIAELIEVPMPFFTAVLYVNEVILCVCITVQTMVRGYGEAERYDQFLERILTVATAVPATEWAKAVLYLRVRLHWLGTTFTVIFSLGLLLDYLHFGSIGATLFSLGAYMLPNMLAAMSLAQYTAGTVLIYKLQQIVNRQLRTATRKQLRGQLQTTKHHYLQLDHCVQLITRSYNVLIVSNVFAGINVTSLQLLEIYQYLQANESKPIYMGYNILWIALQLGMLLMVLCPSDRTKREQTHFGTILFELSQCNEFTGDDVDQQIAHLRLLTLNQKRIVPTACGVLKLELSTLSSIFVALLSFMIILIQFDTSKLNKHGGAVTALDGLYSAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PID4</accession>
    <name>A0A182PID4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PID4"/>
    <dbReference type="STRING" id="199890.A0A182PID4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006696-RA">
        <property type="protein sequence ID" value="AEPI006696-PA"/>
        <property type="gene ID" value="AEPI006696"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006696"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF106">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131309" description="Chitin-binding type-2 domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="115"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006696-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="216" mass="23993" checksum="CB6CC5B39B72ED63" modified="2016-09-07" version="1">MHTAAAIPLLLLGLGAIQSLLACEHASRASAPHWLTVVPNHWMCSAPNSFDIFPHETDCARYYECVCNDAYEYACAPGLRFNTRKLRCENSPLCSGGAAPEESSPGMEPPVGPMDPRCPSLESVKVWTDEHNCAKYYQCARGQVLELHCPETLVYDSALKRCTLPNPDKCCAPVPAAPTLQEELDETEAEEQEEEEAEYGAEEHESFWDRIQSWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PII8</accession>
    <name>A0A182PII8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="5">eIF3e</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PII8"/>
    <dbReference type="STRING" id="199890.A0A182PII8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006750-RA">
        <property type="protein sequence ID" value="AEPI006750-PA"/>
        <property type="gene ID" value="AEPI006750"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006750"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="254"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006750-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="470" mass="54879" checksum="AA84172B836BCE6E" modified="2016-09-07" version="1">LFFSPNKPCDLSTCRSREQFFIKFLWENVKLPLKSATMAKFDLTAKNCQYLDRHLTFPLLEFLLQKKIFDQTSLLKFILETVSKTNMVDYKHDIRERLAMDKVNPEELAQGRANVLATLKELQAEVAPLMKCMEELKNPDSTKDSKSVINALQQTLDYDIILSAQKLAKYLYECGNYNDSLSYLYVCMLVMEPNDKNYLGVLWGKLAVEILTLNWQTALEDLTRLRDFIENYNFTSIQVLQQRAWLIHWSVLVFYNHGKGRDLIIDMFLYKPQYLNAIQTMCPHILRYLATAVIINRGRRNALKDLIKVIQQESYTYRDPITEFLEHLYVNFDFEGARKKLHECQTVIVNDFFIIGCLTEFVENARLMIFETFCRIHQCITIGMLAEKLNMKPDEAECWIVNLIRNARLDAKIDSKLGHVVMGTQPLSPYQQLVEKIDSLSVRSEALTLLVERKHKAKTQEAGEGHWKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIQ4</accession>
    <name>A0A182PIQ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PIQ4"/>
    <dbReference type="STRING" id="199890.A0A182PIQ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006817-RA">
        <property type="protein sequence ID" value="AEPI006817-PA"/>
        <property type="gene ID" value="AEPI006817"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006817"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000602">
        <property type="entry name" value="serine/threonine-protein kinase Nek9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051997">
        <property type="entry name" value="STK_NEK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44535">
        <property type="entry name" value="PROTEIN CBG16200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44535:SF5">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="69"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="15">
        <location>
            <begin position="428"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="15">
        <location>
            <begin position="481"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="15">
        <location>
            <begin position="533"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="15">
        <location>
            <begin position="642"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="707"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="716"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006817-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="732" mass="79622" checksum="FC25F0D3B1CE1FDA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIY2</accession>
    <name>A0A182PIY2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIY2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006895-RA">
        <property type="protein sequence ID" value="AEPI006895-PA"/>
        <property type="gene ID" value="AEPI006895"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006895"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343:SF17">
        <property type="entry name" value="CELLULAR REPRESSOR OF E1A-STIMULATED GENES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343">
        <property type="entry name" value="CREG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="3">
        <location>
            <begin position="64"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006895-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="271" mass="30143" checksum="81BF0A27B907D9E0" modified="2016-09-07" version="1">MTIPSVTYKQFGETVVPVAPVGTKRWIVLYIMVAAVLLTTLACWNNLSGGSLIEMFEDDSDAPPPHTEYAKMARYLVHKAEWVSMGSLSTVDAIKGFPMVNIISVADSARNEKSTGTLYFYLTMLDYTAQDLHKDNRLTVMLTLDQDLYCSKNGIDPMEPTCARIMISGRADKIENGTEEYAFGSRAMFTRHPAAQKWIQTDGHNFFLCKLNITQIAVLDFYGGPHYVTLDDYMAADPDKRTEAVSSSSTGNERQIPPRFSTTEDSTATMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ28</accession>
    <name>A0A182PJ28_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJ28"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006942-RA">
        <property type="protein sequence ID" value="AEPI006942-PA"/>
        <property type="gene ID" value="AEPI006942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006942"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF3">
        <property type="entry name" value="GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="178"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006942-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="612" mass="67289" checksum="2676EEE2480B1DE9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ97</accession>
    <name>A0A182PJ97_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJ97"/>
    <dbReference type="STRING" id="199890.A0A182PJ97"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007011-RA">
        <property type="protein sequence ID" value="AEPI007011-PA"/>
        <property type="gene ID" value="AEPI007011"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007011"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007011-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="246" mass="28164" checksum="D679F8B1A102ADE1" modified="2016-09-07" version="1">MEFTPKEVVLSLLQRYAVGPRPKDDEFFRDGNSYIKPFVKLGVLSTFPIEEAEPEDVEISCNVPDCNFFCQSVMDYEFHYNAQHRYTCAQCKKSLPNAHLLDLHLSETHDSYFAAQVQSSKRAMYACFLEECKHRSSDPSERRDHCIREHRFPHNFRFDTPRNAQPKPGKQQPSKSVPMEADSAPPSTSPQKGETIATLKCRKNFSFGHPQQRTFKTGKMATGPPKCDILESNKMVIDLLDSLPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJW7</accession>
    <name>A0A182PJW7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJW7"/>
    <dbReference type="STRING" id="199890.A0A182PJW7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007233-RA">
        <property type="protein sequence ID" value="AEPI007233-PA"/>
        <property type="gene ID" value="AEPI007233"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007233"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007233-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="207" mass="23385" checksum="F06ECC7EDB4AB8BF" modified="2016-09-07" version="1">MGGYPQQSYGGYGQNPAAAAGGYGGGYGGYAPPPQQPPVNPEIQNIFRNIDKDNTGRINNRELQQALINGRGDHFSDTACNLMISMFDRNKTGTVDIYDFEKLYNYINQWLHVFKNFDRDASGHIEENELTQALTQMGFRFSPQFIQYLIAKNDPINRKEISVDQFIVTCIQIQRFTDAFRVRDTEQKGIITIGFEDFLGIALSMCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK40</accession>
    <name>A0A182PK40_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PK40"/>
    <dbReference type="STRING" id="199890.A0A182PK40"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007306-RA">
        <property type="protein sequence ID" value="AEPI007306-PA"/>
        <property type="gene ID" value="AEPI007306"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007306"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007306-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="271" mass="29577" checksum="A4833050A050CAC9" modified="2016-09-07" version="1">MPPQILPILGSSGTTSTKMQSRDHPFNRSTRPLLERRAQPQVVSTKKPFHYGASSQQPDQQPTGPTRGYNDFNLISRQYETWNSNHSHKGYPYGSPPSPTHDFQFSDIEGPQQRAQQHQRTVHQYTVNSNNSDDEDDYDELVYHHNQLNVASSGLKAANQQLRRRLLDAASPTPPVPPQRTVHKTPPPPPSRRTDASVVPVAPADIDGPFVFGVHHPNTFTPAYGAKATLYGTGATTIGGKDATDALHSSPDTSQVSGSATLPVCAICVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKM6</accession>
    <name>A0A182PKM6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKM6"/>
    <dbReference type="STRING" id="199890.A0A182PKM6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007493-RA">
        <property type="protein sequence ID" value="AEPI007493-PA"/>
        <property type="gene ID" value="AEPI007493"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007493"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007493-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="115" mass="13093" checksum="82A6063EC2EBBC99" modified="2016-09-07" version="1">MTSPLPLLRSFSTENQNRDWSKRFSLRIKQKSSNDGKLDFASLRKNKFARRCSSLRQQPTEQTTSSVTLELESASPAHSMTIHENSSPKKPKWEVIEHFKSNVRGQESISSSLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKT7</accession>
    <name>A0A182PKT7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKT7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007554-RA">
        <property type="protein sequence ID" value="AEPI007554-PA"/>
        <property type="gene ID" value="AEPI007554"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007554"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007554-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="204" mass="21336" checksum="5B9131185069B9F2" modified="2016-09-07" version="1">MMDRSCASAASATGSPTASLPSCTSLVRCSKAVLQTDEPDTVTVELEEHRERLQVAGPEPVLPPCQQPKLAITQLASLASISTAATATQQIITTTVVHDNSSHQSIAATAAGETSATQPTQQRELNKAGSSSTTRTASDPEVSCPQTSQRPPGAEVSSPTPSTSTAVAAPRRICTLKVKIFLIKHLSKLVACNKKMFLPVKSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLR5</accession>
    <name>A0A182PLR5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLR5"/>
    <dbReference type="STRING" id="199890.A0A182PLR5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007887-RA">
        <property type="protein sequence ID" value="AEPI007887-PA"/>
        <property type="gene ID" value="AEPI007887"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007887"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007887-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="168" mass="17202" checksum="8AB93E9BFBC45635" modified="2016-09-07" version="1">MRWFKRSTESPKLLSLSPLRHSESGNVYGGNDPPTSGALLLDRTTLRRRSAGDGTGSAFEMNPAGEEPATCHLSSTPSSPSSTSGSSGSSGSSPSSSSNVSSSSSTSSSSSPFSYTSDSKGSSLGSGGTHKILQSGTATTPRKSRIGDFFGQSAISCHRVRPPSYPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM71</accession>
    <name>A0A182PM71_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PM71"/>
    <dbReference type="STRING" id="199890.A0A182PM71"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008044-RA">
        <property type="protein sequence ID" value="AEPI008044-PA"/>
        <property type="gene ID" value="AEPI008044"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008044"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38753">
        <property type="entry name" value="SLR1441 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38753:SF1">
        <property type="entry name" value="SLR1441 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131651" description="GH18 domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="471"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="674"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="843"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="955"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008044-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1218" mass="136737" checksum="BF070A0CA58839C1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMR1</accession>
    <name>A0A182PMR1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CXXC-type zinc finger protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">PHD finger and CXXC domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMR1"/>
    <dbReference type="STRING" id="199890.A0A182PMR1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008235-RA">
        <property type="protein sequence ID" value="AEPI008235-PA"/>
        <property type="gene ID" value="AEPI008235"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008235"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15553">
        <property type="entry name" value="PHD_Cfp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000138">
        <property type="entry name" value="CXXC-type zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022056">
        <property type="entry name" value="CpG-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12269">
        <property type="entry name" value="CpG_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="14">
        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008235-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="481" mass="55173" checksum="B7D1B8CFE3FAC8A2" modified="2016-09-07" version="1">MSEIKKRKKKSKEEIAKEFDLPERKSKIATIYKQDGQSYCLCRSSDSSRFMICCDACEEWYHGDCINVSEKEAKHIKHYYCQRCKEEDPSLQTVFRLVPAPGPIPLPEEKKFQKKKKEKPLGGSSEKRCGNCDGCLAENCGACESCLGPTKNGRKQRCEMRTCSNTSTRKKDRAAMKAGGRNKKRKMSLTPEVIRNPALEGERQCYGPGCIMTARPQSKYCSDECGMKLATSRIYQVLPQRIQEWSLSPAVGEEQNKKALESIRTKQAIVRATLAELDKRHAELDLLVERAKRCTLDPNALENTDVEDEMSMYCITCGHEIHSKTAIRHMEKCFNKYESQASFGSIFKTRIDGNSMFCDFYNPASKTYCKRLRVLCPEHCKDPKVNDTDVCGCPLIRNVFQLTGEFCRAPKKSCFKHYVWEKIRRAEIDLERVRQWLKMDELVEQERQIRQAMASRAGVLGLMLHSTYNHDVMEKLCAGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMR3</accession>
    <name>A0A182PMR3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PMR3"/>
    <dbReference type="STRING" id="199890.A0A182PMR3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008237-RA">
        <property type="protein sequence ID" value="AEPI008237-PA"/>
        <property type="gene ID" value="AEPI008237"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008237"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46848">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46848:SF1">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008237-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="727" mass="81272" checksum="FEF61A3722C70C9C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN09</accession>
    <name>A0A182PN09_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182PN09"/>
    <dbReference type="STRING" id="199890.A0A182PN09"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008333-RA">
        <property type="protein sequence ID" value="AEPI008333-PA"/>
        <property type="gene ID" value="AEPI008333"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008333"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF124">
        <property type="entry name" value="ARGININE METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="8">
        <location>
            <begin position="88"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="9">
        <location>
            <begin position="193"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008333-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="370" mass="42461" checksum="A5FF9531E8185613" modified="2016-09-07" version="1">MQASTSTDVPMESVDSAGPATGALSPNTVNGNGNDLATNAEDMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNAMYHNKHLFKGKVVLDIGCGTGILSMFAAKAGAAKVIAIECSNIIDYAQKIIEANNLKETITLVKGKVEEVTLPDGYDQVDIIISEWMGYCLFYESMLDTVIYARDKWLKKDTGMMFPDRCTLFVTAIEDRQYKDEKINWWDDVYGFNMSSIRKVAISEPLVDVVDPKQVVTSAYMVKEIDLYTVRKEDLEFESSFCLMVKRNDFIQALVTYFNVEFTKCHKRLGFSTAPDAPYTHWKQTVFYFDDYLTVKKGEEVHGTFKMKPNVRNNRDLDFTIDLQFKGELSKVDEKNHYRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNG5</accession>
    <name>A0A182PNG5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNG5"/>
    <dbReference type="STRING" id="199890.A0A182PNG5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008492-RA">
        <property type="protein sequence ID" value="AEPI008492-PA"/>
        <property type="gene ID" value="AEPI008492"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008492"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000003">
        <property type="entry name" value="Pyruvate dehydrogenase phosphatase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000004">
        <property type="entry name" value="Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF15">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="72"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="435"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="493"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="815"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008492-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="937" mass="105312" checksum="4B668014816F6EC4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNI6</accession>
    <name>A0A182PNI6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNI6"/>
    <dbReference type="STRING" id="199890.A0A182PNI6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008513-RA">
        <property type="protein sequence ID" value="AEPI008513-PA"/>
        <property type="gene ID" value="AEPI008513"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008513"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008513-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="442" mass="49247" checksum="7FB0518356D3CAD0" modified="2016-09-07" version="1">MEGSQEELNLEFNIIDNIIGSAVDDGLMKDSSVHYDYKTLLPLLQPLCRFCVRENGQMMHISDVHQQIINDLRIPEIHGRSVCTNICGNCNGFLEEFCKFRSVCEEGQKRLATLLAGRHVLPHYLKLDSTVPNQEPLSVDTSALCDHKSLSSIETGKSSPEYVVSETTIVTGTGDGMSPITLHLSVVKLQDVHPQSEVQQRTAQELVHHSSNSPDRGYGTHVPEESNNIQIAEEITCDETFSNNAKDIINAHTFKTVIDEKPKNKPVAQKRTQKPEARRRVVEGRLEWICLDCEQIFSSCLQLKKHRRSCEFVGSKTSKRLATLGCDICGETMSTESALTMHRRKHEAKVKRPTASKKFPSLGLEPIVCHVCGHTKQTDSNSWDDLIEYQPEDILSATTDDTTSEATVLVMAGESTNDTCPPEMLSPYASDELYNICSIAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP61</accession>
    <name>A0A182PP61_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PBZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PP61"/>
    <dbReference type="STRING" id="199890.A0A182PP61"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008740-RA">
        <property type="protein sequence ID" value="AEPI008740-PA"/>
        <property type="gene ID" value="AEPI008740"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008740"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22671">
        <property type="entry name" value="FHA_APTX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039253">
        <property type="entry name" value="APLF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21315:SF2">
        <property type="entry name" value="APRATAXIN AND PNK-LIKE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21315">
        <property type="entry name" value="APRATAXIN AND PNK-LIKE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBZ-type" evidence="2">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="PBZ-type" evidence="2">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008740-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="411" mass="45467" checksum="C40F48FE08146E4C" modified="2016-09-07" version="1">MKHLVIIDSSKQTRKVVPECGQDIGRGKFLEIAAKTSTIIFQCDDKRVSRTHGRITKEVKDNKLLLRLESLHLNPIFCRKKDGTTDYTLKKDEGILLEIGDKFKLIVDGVWFEVGEDVTETDSQRTAMSLEDENQNNPSGDTTPCKRKHDAEQADDQSKRQRILGENERNDEPSTSTQLPADSEQMTVPDSSSAGIEAPVEIKPDPDSLPTDGSTTQVLIKAEPNADTNDAGCSGNGVAMGGQLPQLTLKPDPDGLGAKVAIPVPTFPVVANPGVLRPSCDYGIRCYRAGQDHRSMYAHPGDFDYRRPSFPPPPPGSPLCPFGARCYRRNPQHFREYDHPDPNADLLLIRPVRRAAPRRQADDNMSDDELPYESEPDFDDSSSDEYLPGRMDDESDELGSAEEDNDSGLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPG8</accession>
    <name>A0A182PPG8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPG8"/>
    <dbReference type="STRING" id="199890.A0A182PPG8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008847-RA">
        <property type="protein sequence ID" value="AEPI008847-PA"/>
        <property type="gene ID" value="AEPI008847"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008847"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11387">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008847-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="76" mass="9013" checksum="FD368D433606720A" modified="2016-09-07" version="1">MAYEPKTAPFDPRFPNQNQTKHCYQSYLDFHRCEKVKGEGDQVCKYFKSVFNSMCPNSWVEKWDTQREEGTFAGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ37</accession>
    <name>A0A182PQ37_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQ37"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009067-RA">
        <property type="protein sequence ID" value="AEPI009067-PA"/>
        <property type="gene ID" value="AEPI009067"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009067"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009067-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="431" mass="50025" checksum="51089D0A45F3CA09" modified="2016-09-07" version="1">IRNAGSPLQDINFQEFKKKLIVSKETQSFCSQLTTMWMDATTARITLNSIRIKSFVDRTRTPEVLCVLMEMEGIFLIRGEIDIVQLREEFLHHIRDCNSSHMRLCLPQFILPFMSCWNKYAWLKGTRSADEHIVLAPAIQRGRPIKELMCLLNITNTIAGSTASVKDPLITNPKPAALPWQIVCIPVMGDSASACGEKCVTSNYLLYAIDLRLLNDAEKRNLSYIPFNGYLDRGELMFDNFLSKPYYVPRLWNYIFSNLHYRWNEFVYQHDPLESPDIDRKQYTGMGQLLSVLFISIVHVCSDFVCSFRSIKGSPLDKIDYLQRLIEREIDKRNLTARTIWDTFRQTMEPVNLLKEAIFFVWKIVATVTFMVPWYAWRETEALLLYVSKRTVNSDTIVGFIVECTPICYGVLLECCRMLWLLVEVTLQLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQT0</accession>
    <name>A0A182PQT0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQT0"/>
    <dbReference type="STRING" id="199890.A0A182PQT0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009311-RA">
        <property type="protein sequence ID" value="AEPI009311-PA"/>
        <property type="gene ID" value="AEPI009311"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009311"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000141">
        <property type="entry name" value="Enterokinase light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131698" description="Peptidase S1 domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="94"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="388"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="664"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009311-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="794" mass="87508" checksum="A8B45B61F3FBA3FC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQY0</accession>
    <name>A0A182PQY0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Equilibrative nucleoside transporter 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQY0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009361-RA">
        <property type="protein sequence ID" value="AEPI009361-PA"/>
        <property type="gene ID" value="AEPI009361"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009361"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008504">
        <property type="term" value="F:monoamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009361-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="71258" checksum="A77942281CB1FB15" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRC9</accession>
    <name>A0A182PRC9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lysozyme</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRC9"/>
    <dbReference type="STRING" id="199890.A0A182PRC9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009513-RA">
        <property type="protein sequence ID" value="AEPI009513-PA"/>
        <property type="gene ID" value="AEPI009513"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009513"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16899">
        <property type="entry name" value="LYZ_C_invert"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.530.10:FF:000001">
        <property type="entry name" value="Lysozyme C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001916">
        <property type="entry name" value="Glyco_hydro_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019799">
        <property type="entry name" value="Glyco_hydro_22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000974">
        <property type="entry name" value="Glyco_hydro_22_lys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407:SF36">
        <property type="entry name" value="GEO02684P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00062">
        <property type="entry name" value="Lys"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00137">
        <property type="entry name" value="LYSOZYME"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00135">
        <property type="entry name" value="LYZLACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00263">
        <property type="entry name" value="LYZ1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00128">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51348">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131702" evidence="5">
        <location>
            <begin position="22"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 22 (GH22)" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 22 (GH22)" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009513-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="359" mass="40465" checksum="210FE45CBDCAA367" modified="2016-09-07" version="1">MKVFSIAALTIVVACSVVIEAKKFGKCELAKALANNGIAKASLPDWICLVQNESAFSTSATNKNKNGSTDYGIFQINNKYWCDSGYGSNDCKIACSSLLNDDITDDIKCAKLIHKRHGFNAWYGWKNHCNGKTLPSVRICLVENESRYDSTALNAKNKDGSTDYGIFQINNRYWCAEGKVGPNECKLQCRSLRDDNIIDDIRCAKFIYARHRFNAWVAWRNKCNGKTKPILLAVVVSCSVSEAKTFTKCELVKALYSRGIPKKSLPDWVCLVQWESSFRTTATHVNDDGSTDYGIFQINNQYWCDSSYGSNACRYLLTDDISDDIKCAKLIYSQHRFEAWYGWVQHCKGQSLPDVSECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRW5</accession>
    <name>A0A182PRW5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="STRING" id="199890.A0A182PRW5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009700-RA">
        <property type="protein sequence ID" value="AEPI009700-PA"/>
        <property type="gene ID" value="AEPI009700"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009700"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000080">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000218">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000132">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000444">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 6/32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000221">
        <property type="entry name" value="Ubiquitin-specific peptidase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057368">
        <property type="entry name" value="USP32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF76">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25265">
        <property type="entry name" value="USP32_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="263"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="7">
        <location>
            <begin position="425"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="810"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1112"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1168"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1234"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1489"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1714"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1112"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1168"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1180"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1234"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1253"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1493"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1506"/>
            <end position="1519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009700-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1941" mass="213945" checksum="309BF98A82D6042B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRX9</accession>
    <name>A0A182PRX9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRX9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009714-RA">
        <property type="protein sequence ID" value="AEPI009714-PA"/>
        <property type="gene ID" value="AEPI009714"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009714"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009714-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="196" mass="22739" checksum="8077B19F206C8FE3" modified="2016-09-07" version="1">MLNLETGEIEYGTVGGYDRDRIYLDKETGEVSSDPTELVGSRRRRSKFHIPKQYLRNQCGIIGRRPAPPVVAAPSVSCALMACKQQKMIPMMKEEITVGYNSTAHLLFLLPLLFMTPKLFALVISFIEVMLHMWAHRKNSTNDNPDVYYRSPMHVVTRQFCEICRHERLMGRVGKLQDVRMRQMQNYFRKVTRNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS91</accession>
    <name>A0A182PS91_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with ribosomal protein S21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PS91"/>
    <dbReference type="STRING" id="199890.A0A182PS91"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009826-RA">
        <property type="protein sequence ID" value="AEPI009826-PA"/>
        <property type="gene ID" value="AEPI009826"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009826"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000012">
        <property type="entry name" value="40S ribosomal protein SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="9">
        <location>
            <begin position="201"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009826-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="285" mass="31570" checksum="A959089DC4F01F97" modified="2016-09-07" version="1">MSGNLDILSLKEDDVTKMLAATTHIGSTSVNFQMEQYVYKRRSDGVHIINLGRTYEKLLLAARCIAAIEYPGEVYAMSSRPYGQRAVLKYAHYTEATPIAGRFTPGAFTNQVQSTFREPRLLIVTDPLTDHQPVTEASYVNIPVIAFCNTDSPVKFVDIAIPCNTKSTHSIGLMWWLLAREVLRLRGKITHDRWEVMPDLFFFRDPEEAEKEQAAIEAAAPVIKELPDEPVVADDQGHWGEDVPRTTLAMPQATPLATVGQSDDWNEEDTAPAAAGATSWGGSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSS9</accession>
    <name>A0A182PSS9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bee-milk protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSS9"/>
    <dbReference type="STRING" id="199890.A0A182PSS9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010015-RA">
        <property type="protein sequence ID" value="AEPI010015-PA"/>
        <property type="gene ID" value="AEPI010015"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010015"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000045">
        <property type="entry name" value="Blast:Protein yellow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF19">
        <property type="entry name" value="RE55542P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131839" description="Bee-milk protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010015-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="61031" checksum="0CD2E34759A7F3A8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTC8</accession>
    <name>A0A182PTC8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTC8"/>
    <dbReference type="STRING" id="199890.A0A182PTC8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010214-RA">
        <property type="protein sequence ID" value="AEPI010214-PA"/>
        <property type="gene ID" value="AEPI010214"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010214"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07660">
        <property type="entry name" value="BAR_Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000003">
        <property type="entry name" value="arfaptin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF5">
        <property type="entry name" value="ARFAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="6">
        <location>
            <begin position="106"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010214-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="325" mass="37469" checksum="4E60F0CA1757123D" modified="2016-09-07" version="1">MYATNMNKSNEKSIHEMLKNTPSMNDSTDVVHTGSEQQTIKHSTTLTLRNVSNHSLSSPTSVSLEDESAYIKNGSSKLDTFRNWSITTYKCTKQIMLEKLGKSTRTVDLELEAQIDQLKETQKKYLSILRLSRAFTSHFYNCMQTQSLLSETFADLAQKSPELQEEFLRNAETQRILTKNGELLLNALNFFISSINTLCNKTIEDTLLTIRQYELARVEYDAYRVDMEQQRTGGSETQQKYSNDEVQKKYEKCKDQYEKLRSDIVVKMQFLEENRIKVMHKQLLLFHNAIAAYFAGNANGLEKTLQQFNISLKSPNSVTSSWLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTE3</accession>
    <name>A0A182PTE3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTE3"/>
    <dbReference type="STRING" id="199890.A0A182PTE3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010229-RA">
        <property type="protein sequence ID" value="AEPI010229-PA"/>
        <property type="gene ID" value="AEPI010229"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010229"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF35">
        <property type="entry name" value="ACTIN-BINDING PROTEIN IPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="79"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010229-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="624" mass="68702" checksum="A60F2A782995B174" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTE7</accession>
    <name>A0A182PTE7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PTE7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010233-RA">
        <property type="protein sequence ID" value="AEPI010233-PA"/>
        <property type="gene ID" value="AEPI010233"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010233"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000487">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046872">
        <property type="entry name" value="DRHyd-ASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046873">
        <property type="entry name" value="HisK-N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043969">
        <property type="entry name" value="MAP3K_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025136">
        <property type="entry name" value="MAP3K_TRAF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF394">
        <property type="entry name" value="APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19039">
        <property type="entry name" value="ASK_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20309">
        <property type="entry name" value="DRHyd-ASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20302">
        <property type="entry name" value="HisK-N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13281">
        <property type="entry name" value="MAP3K_TRAF_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="624"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="787"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1138"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1265"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1142"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1280"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010233-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1392" mass="157649" checksum="F8682F48373AC8BE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTS1</accession>
    <name>A0A182PTS1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PTS1"/>
    <dbReference type="STRING" id="199890.A0A182PTS1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010357-RA">
        <property type="protein sequence ID" value="AEPI010357-PA"/>
        <property type="gene ID" value="AEPI010357"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010357"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038062">
        <property type="term" value="F:protein tyrosine kinase collagen receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF580">
        <property type="entry name" value="DISCOIDIN DOMAIN RECEPTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010357-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="73" mass="8620" checksum="75376ED453D4AC3E" modified="2016-09-07" version="1">MPIRWMAWESVLMGKFTSKSDVWSFAVTLWEILTFAREQPFENLSDDKVIENIGHMYQDNKKHSALYVEHQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTY4</accession>
    <name>A0A182PTY4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTY4"/>
    <dbReference type="STRING" id="199890.A0A182PTY4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010420-RA">
        <property type="protein sequence ID" value="AEPI010420-PA"/>
        <property type="gene ID" value="AEPI010420"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010420"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF31">
        <property type="entry name" value="SIDESTEP II, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="720"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="80"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="202"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="309"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="405"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="504"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="869"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010420-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="924" mass="104086" checksum="9376CBED2ABF6CCD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUF7</accession>
    <name>A0A182PUF7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PUF7"/>
    <dbReference type="STRING" id="199890.A0A182PUF7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010593-RA">
        <property type="protein sequence ID" value="AEPI010593-PA"/>
        <property type="gene ID" value="AEPI010593"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010593"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="35"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010593-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="220" mass="25517" checksum="96710CF50F629D0F" modified="2016-09-07" version="1">MPQICTLLPLIPFLRSHRFLQIITQALDRYRADEMFISFNGGKDCTVLLDLIHNANLKDAKRIKCIYVRPLNPFSEIEEFVERCRQHYDITISTVDGGIKEALEQICRTDPQLKACIMGSRRSDPYCERLASFQETDPGWPRLMRINPLLEWTCEDIWSYIREHDVPYCALYDRGYTSIGDRTNTIPTPPLKVETDSGEVTYLAAYTLQDADRYERAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUH4</accession>
    <name>A0A182PUH4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="6">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coq5</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with PYURF; the interaction is direct, stabilizes COQ5 protein and associates PYURF with COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182PUH4"/>
    <dbReference type="STRING" id="199890.A0A182PUH4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010610-RA">
        <property type="protein sequence ID" value="AEPI010610-PA"/>
        <property type="gene ID" value="AEPI010610"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010610"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000064">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010610-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="269" mass="31084" checksum="DFB83752CDB4C225" modified="2016-09-07" version="1">MLPLRRASLLVHRLSLVRFLSNAKENHSSAQQDSETHFGFQTVKESDKWKKVHKIFEEVAASYDLMNDAMSMGVHRIWKDIFMERLSPVGNGIRLLDMAGGTGDIAFRYMKYLQTLPAADRTPSHVTVCDINQNMLDVGQQRWEKLKLPTGGDTIEWVCADAEKLPFEDSSFSVYTIAFGIRNCTHIDRVLAEAYRVLKPGGRFMCLEFSHVNNEYLKWLYDQYSFQVIPPMGQILANQWQPYQYLVESIRKFPQQNEFKAMIQNAGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUH9</accession>
    <name>A0A182PUH9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="7">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A182PUH9"/>
    <dbReference type="STRING" id="199890.A0A182PUH9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010615-RA">
        <property type="protein sequence ID" value="AEPI010615-PA"/>
        <property type="gene ID" value="AEPI010615"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010615"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000092">
        <property type="entry name" value="Leucine carboxyl methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF33">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010615-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="332" mass="38258" checksum="DB5BEC2EE42D61A2" modified="2016-09-07" version="1">MEPPSFHPCDEAVISTNDDASNCKRSAVKLGYWKDDYIAHFVRNPDRKAPEINRGYYARVKGIEMCIEKFFKVSGVRANVSQEENVRNKTGDKCQIVNLGCGFDTLYWRLREAGHMVTNFVELDFPNVTSRKCYQIKRNKVLLEKIHVEDGEVRLSPTDLHSTNYHIVGVDLRNIEEVALKLQQSEIDYSVPTIFLAECVLVYIEPQNCHNLLKWFAANFKTAAFVNYEQVNMNDRFGEVMLTNLRQRGCSLAGVDSCVSLDAQISRFLQCNWHGARAWDMVQIYHSIPASERARTERIEMLDEAELLVQLFQHYCISIAWIGDLFQDIEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV41</accession>
    <name>A0A182PV41_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PV41"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010828-RA">
        <property type="protein sequence ID" value="AEPI010828-PA"/>
        <property type="gene ID" value="AEPI010828"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010828"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1060"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1084"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1125"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1197"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="Ferlin dsRNA-binding" evidence="15">
        <location>
            <begin position="35"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="518"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="625"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="658"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="760"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="1025"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010828-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1396" mass="157230" checksum="F53A88A652CD9AE8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV49</accession>
    <name>A0A182PV49_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidylpeptidase IV N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PV49"/>
    <dbReference type="STRING" id="199890.A0A182PV49"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010836-RA">
        <property type="protein sequence ID" value="AEPI010836-PA"/>
        <property type="gene ID" value="AEPI010836"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010836"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF135">
        <property type="entry name" value="INACTIVE DIPEPTIDYL PEPTIDASE 10-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="3">
        <location>
            <begin position="162"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="683"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010836-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="83056" checksum="A3B11441614376CC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVX2</accession>
    <name>A0A182PVX2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-pyruvoyltetrahydropterin synthase</fullName>
            <ecNumber evidence="4">4.2.3.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTPS family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PVX2"/>
    <dbReference type="STRING" id="199890.A0A182PVX2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011109-RA">
        <property type="protein sequence ID" value="AEPI011109-PA"/>
        <property type="gene ID" value="AEPI011109"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011109"/>
    <dbReference type="UniPathway" id="UPA00849">
        <property type="reaction ID" value="UER00819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00470">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.10:FF:000003">
        <property type="entry name" value="6-pyruvoyl tetrahydrobiopterin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="entry name" value="6-pyruvoyl tetrahydropterin synthase/QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022470">
        <property type="entry name" value="PTPS_Cys_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00039">
        <property type="entry name" value="6PTHBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589:SF7">
        <property type="entry name" value="6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00987">
        <property type="entry name" value="PTPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011109-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="175" mass="20069" checksum="1932F5600C79677E" modified="2016-09-07" version="1">MSSRPQVYLTRKECFSACHRLHSPFLSEEANRQVYGKCNNPNGHGHNYTVEVTVRGPVDSKTGMVMNITDLKEYMEQAIMKKLDHLNLDKDVPYFKNLASTTENVAIFIWDSLKLIMDKPELLYEIKIYETDKNSVIYRGEKHTVGHHHHHEAVKQSRVTNSSENSSNLSSDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW78</accession>
    <name>A0A182PW78_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transforming acidic coiled-coil-containing protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PW78"/>
    <dbReference type="STRING" id="199890.A0A182PW78"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011215-RA">
        <property type="protein sequence ID" value="AEPI011215-PA"/>
        <property type="gene ID" value="AEPI011215"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011215"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000001">
        <property type="entry name" value="Transforming acidic coiled-coil-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011215-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="189" mass="22442" checksum="0E3617734D6A8ABF" modified="2016-09-07" version="1">MHDVELREESMLKRITEKDKTISKMSNVVEAYERTIAELISEKEILIRNHEIECESLKQDNEINAQHLESLEKTFSNLYAKYERMKKNAIKYKENEEKLLEKVLKLEECLRAQEQRYEKMKSHAMSQLEIANVKIDEAIRNHSQESAKLKAQIKKEELYRISINEQLIQKSKENEELVKICDELISETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWM2</accession>
    <name>A0A182PWM2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWM2"/>
    <dbReference type="STRING" id="199890.A0A182PWM2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011359-RA">
        <property type="protein sequence ID" value="AEPI011359-PA"/>
        <property type="gene ID" value="AEPI011359"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011359"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="69"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011359-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="129" mass="14703" checksum="E5E18640546EBC67" modified="2016-09-07" version="1">MYAKRSALSHVNLMEELRLEPTDWLNYLRMDEDSYLWLLERLPKNPTEWKKIGNDFNNKWQFPNCLGAVDGKHVRISPPSGGGSQFFNYKKFNSIVLMAVVDANYRFIMCDVGGLGSDSDGACIQATSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWQ3</accession>
    <name>A0A182PWQ3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWQ3"/>
    <dbReference type="STRING" id="199890.A0A182PWQ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011390-RA">
        <property type="protein sequence ID" value="AEPI011390-PA"/>
        <property type="gene ID" value="AEPI011390"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011390"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011390-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="172" mass="18880" checksum="F3A71B344DFF289E" modified="2016-09-07" version="1">MNQQDYPQSPGRENGNATTCYSRDATLNVSQAQILARQSVNAKLPTFSGNPEEWNAFDLCGFSDGENIARLQQALKGDALRTVQGRLRHAANLREVMEELKSSFGRPESLVDELGLEGSDRPLCLKWTGGQHRMEPNSKQVSVSIMGTSCGAQKFQASNVRSVKCLGLPPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWR0</accession>
    <name>A0A182PWR0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWR0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011397-RA">
        <property type="protein sequence ID" value="AEPI011397-PA"/>
        <property type="gene ID" value="AEPI011397"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011397"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF241">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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    <sequence length="588" mass="65396" checksum="FBF4E10F27D03CE6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PXA3</accession>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Larimer J."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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            <dbReference type="Proteomes" id="UP000075885"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYZ6</accession>
    <name>A0A182PYZ6_9DIPT</name>
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                <person name="Howell P."/>
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                <person name="Haas B."/>
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        <scope>IDENTIFICATION</scope>
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            <begin position="21"/>
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        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="240" mass="27873" checksum="CB69205DE11D6B26" modified="2016-09-07" version="1">MHRWCKRLALCGIFLLYVSACTSSEEVASIVQHQEWFSEYATILESTMQIKRQGNTNATLFFNKELLKLLANATIEMRLIDNTTEGTIVQSAVIGQPCRVLLLEMFKIFRTIGQAELKACAAYISEQLSYWTTQRFFSFANIVHRDATELTHRVALVLEQYNKITELENILDTLQEEYYEFNTHNSALQEVLNRELDRFARPDHPVRESLRDCLDTTVTLHQLDMKYVLGYIDTDCMPQK</sequence>
</entry>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Howell P."/>
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                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A240PK69"/>
    <dbReference type="STRING" id="199890.A0A240PK69"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015225-RA">
        <property type="protein sequence ID" value="AEPI015225-PA"/>
        <property type="gene ID" value="AEPI015225"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015225"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015225-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="252" mass="28662" checksum="9B12B38D62A76D01" modified="2017-10-25" version="1">MNQYRSEKQLAYLYPIIATLSFVCCISTTVAWQHWRYVLDTCVETNCGCILHGRSTATFFTGGHVAYCHWASYGLVLPIIFCFIFGIFHVFRVCFGRRRRYPGTATVRQRSGDVILMTTKTDVEEDDISPYYWIPASVIGSLMAVLTLVHAAMYLDGFLATCKQQRNELIKNVQANGSLVPIIQSRISCSSVFDFMDYLHLDVSYDRRREGRINTAAALIIGLVCSWICVGLWVWTVVINARRARASKDLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PL02</accession>
    <name>A0A240PL02_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Short form D7 salivary protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PL02"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015306-RA">
        <property type="protein sequence ID" value="AEPI015306-PA"/>
        <property type="gene ID" value="AEPI015306"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015306"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000008">
        <property type="entry name" value="D7-related 4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012805801" description="Short form D7 salivary protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015306-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18595" checksum="A20174630A595423" modified="2017-10-25" version="1">MLRKSLLNAILVWCLFTLGQARQEGTVEECEKNIPASLKGRICELRQYTPVQGKDMDAHMQCVLEVVGFVEDNGELAFQELLGVLKMVDPTMDHAGNLKKCDAEAKKVDSSSKANAFYTCFLGTSSVQAFKYAVDYAELVRAGKLDSGAPFDADCVSRLMKEIDDGICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PNC8</accession>
    <name>A0A240PNC8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aegyptin/gSG7 salivary protein-like four-helix bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PNC8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015313-RA">
        <property type="protein sequence ID" value="AEPI015313-PA"/>
        <property type="gene ID" value="AEPI015313"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015313"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056799">
        <property type="entry name" value="ALL3/gSG7_salivary-like_helix"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25001">
        <property type="entry name" value="Aegyptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012105243" description="Aegyptin/gSG7 salivary protein-like four-helix bundle domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Aegyptin/gSG7 salivary protein-like four-helix bundle" evidence="6">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015313-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="141" mass="16684" checksum="64E668BE927FC8F6" modified="2017-10-25" version="1">MTTKLVWLFAIIGLVWLLQISPCDATTWHAKHLMPYFRRMKLDKSKNRVYQHDVKYGLRMHLRAPLLQKALCLPKGTKLSSDCLNRMVDKARQHENKFYAKFTYACKQHAEYSADCLDSGRPVYYRDLKNLAKETEQCWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3ERT5</accession>
    <name>A0A9I3ERT5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidoglycan recognition protein long class</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A9I3ERT5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003316-RF">
        <property type="protein sequence ID" value="AEPI003316-PF"/>
        <property type="gene ID" value="AEPI003316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="7">
        <location>
            <begin position="275"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="6">
        <location>
            <begin position="287"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003316-PF"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="49623" checksum="480A243B3BAE4ED6" modified="2023-06-28" version="1">MALARNHQLENGSVTVKNGYHTTTQSLPAGGGDEVLTDPDKADITRGSSLSAITAQSSIKRTDNGDDDDSSVFDSSSDTECDDDSIKRAIDGIPGALAPGEARVLPNGNLKAGSELAVAPGARPSPGASTIGAIAVHNSSDITFGNKTYIKGQVVIKNIYQERKNGSANQGYQVHENESDQTNTSKKVPPASTPPEPRSWQSSLKTIIKDKPLLSFIVMISLMIVLCAIVAVISILTASGKARLRPPVGDGNDNRPNIPQDKDIEDDLFPDPKPLRLVTRTEWLAQPPREELTDLKLPVGKVIIAHTATEGCTTQAKCMYQVKLIQEFHSNPDSRNFSDIAYQFLVGGDGNAYEGRGWTKQGAHTKGFNVDSICIAFIGTFIADPPPVAQLSAAKQLILLGMKENYLASNYSLYGHRQLAPFESPGKALFDIIKTWPHWSNKLGTNHWVEPANETSNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FGJ5</accession>
    <name>A0A9I3FGJ5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine rich immune protein (Coil-less)</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A9I3FGJ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015499-RA">
        <property type="protein sequence ID" value="AEPI015499-PA"/>
        <property type="gene ID" value="AEPI015499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015499-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="43143" checksum="FFD573CC96EBDEE4" modified="2023-06-28" version="1">MGESNFFMNGYIPCHVKEVTYQNVLFNKLDHAFFHALPRHVKHVHITRSPTLRSISIPREITFSEFSITATAINRIEIDERSVIKEFTVDESKFITIPNAISHLQEAEKIGVTDSPITVLDMASFCHLSKLRSLNFHGNRIRHIVNSASKNCSVYNSLQYFHISYNLLKTLHMEVFNAFGKIEVLEIKQNRLRLIQGSFRSTAPLKLYLLKNKLKAIDFCRWNVPHMVFLDLDSNELTALPDCLENISSLTSLFLTRNQIESVTIESFAALSKLEMINLSVNKITTFELHSVRYPRSLRWLYVSNNNITAIDLSLVPVPSLEVFVSGNCISKFDTNNISPNVTILLMIDNPIDCSWQSLQERNNVTCIADAASEERCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZN9</accession>
    <name>A0A182NZN9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182NZN9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000120-RA">
        <property type="protein sequence ID" value="AEPI000120-PA"/>
        <property type="gene ID" value="AEPI000120"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000120"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000059">
        <property type="entry name" value="unconventional myosin-XVIIIa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="327"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="547"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1536"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="641"/>
            <end position="648"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000120-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1584" mass="169845" checksum="10E2C9A981C4B41E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZW6</accession>
    <name>A0A182NZW6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZW6"/>
    <dbReference type="STRING" id="199890.A0A182NZW6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000197-RA">
        <property type="protein sequence ID" value="AEPI000197-PA"/>
        <property type="gene ID" value="AEPI000197"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000197"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="438"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000197-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="514" mass="59801" checksum="820FEE26A7DE33CB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZX9</accession>
    <name>A0A182NZX9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NHR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182NZX9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000210-RA">
        <property type="protein sequence ID" value="AEPI000210-PA"/>
        <property type="gene ID" value="AEPI000210"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000210"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12887">
        <property type="entry name" value="SPRY_NHR_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000001">
        <property type="entry name" value="neuralized-like protein 4 isoform X1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF14">
        <property type="entry name" value="NEURALIZED-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="242"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="467"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="658"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="869"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1513"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1458"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1533"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1563"/>
            <end position="1576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000210-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1881" mass="202839" checksum="54CEDFC2403D1972" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P025</accession>
    <name>A0A182P025_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GGA protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P025"/>
    <dbReference type="STRING" id="199890.A0A182P025"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000257-RA">
        <property type="protein sequence ID" value="AEPI000257-PA"/>
        <property type="gene ID" value="AEPI000257"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000257"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14234">
        <property type="entry name" value="GAT_GGA_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027422">
        <property type="entry name" value="GGA1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45905">
        <property type="entry name" value="GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45905:SF1">
        <property type="entry name" value="GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="12">
        <location>
            <begin position="169"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="561"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000257-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="74896" checksum="2ED32A8E576F7B3B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P093</accession>
    <name>A0A182P093_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein Skeletor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="EnsemblMetazoa" id="AEPI000325-RA">
        <property type="protein sequence ID" value="AEPI000325-PA"/>
        <property type="gene ID" value="AEPI000325"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000325"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057443">
        <property type="entry name" value="At5g54830-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052126">
        <property type="entry name" value="Spindle_Org/Thrombomodulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036:SF13">
        <property type="entry name" value="PROTEIN SKELETOR, ISOFORMS D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036">
        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25489">
        <property type="entry name" value="At5g54830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130709" description="Protein Skeletor" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="5">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="5">
        <location>
            <begin position="142"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="4">
        <location>
            <begin position="278"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="941"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="951"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1307"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000325-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1365" mass="149399" checksum="1713A242970E7B75" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0G8</accession>
    <name>A0A182P0G8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRKCA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein interacting with C kinase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Protein kinase C-alpha-binding protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition. Interacts with SORCS3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Postsynaptic density</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Synapse</location>
            <location evidence="21">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0G8"/>
    <dbReference type="STRING" id="199890.A0A182P0G8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000400-RA">
        <property type="protein sequence ID" value="AEPI000400-PA"/>
        <property type="gene ID" value="AEPI000400"/>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="561" mass="62231" checksum="51B4CC2644AEE3A8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0Q4</accession>
    <name>A0A182P0Q4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 60</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000486-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16564" checksum="14F63BBB5E68B301" modified="2016-09-07" version="1">MGFVQRALFTWFILLVFLVVLCLRLENRINWNWFIVFIPLWLYDAILVAWAVIETPQRQHGSRFVSLQDYQYYVLGIVLKILSKITICLKLEYKSIPMYMMMIPIWLLLVLLIVYIGTHLQPKPRSIGSNRSNRQSAGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0R2</accession>
    <name>A0A182P0R2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0R2"/>
    <dbReference type="STRING" id="199890.A0A182P0R2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000494-RA">
        <property type="protein sequence ID" value="AEPI000494-PA"/>
        <property type="gene ID" value="AEPI000494"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000494"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000032">
        <property type="entry name" value="Nucleolar MIF4G domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="848"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000494-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1057" mass="121460" checksum="DA998CEB741A994B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0Y0</accession>
    <name>A0A182P0Y0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Neogenin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. DCC family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P0Y0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000562-RA">
        <property type="protein sequence ID" value="AEPI000562-PA"/>
        <property type="gene ID" value="AEPI000562"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000562"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000004">
        <property type="entry name" value="DCC isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000133">
        <property type="entry name" value="Neogenin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000551">
        <property type="entry name" value="Protogenin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010560">
        <property type="entry name" value="Neogenin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF54">
        <property type="entry name" value="FI24025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06583">
        <property type="entry name" value="Neogenin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="128"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="234"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="327"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="578"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="677"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="772"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="872"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="975"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="1074"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="461"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1252"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1350"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1390"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1257"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1429"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000562-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1499" mass="166227" checksum="90C65E9029B820CA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P169</accession>
    <name>A0A182P169_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-actin monooxygenase</fullName>
            <ecNumber evidence="4">1.14.13.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-methionyl-[F-actin] + NADPH + O2 + H(+) = L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) + H2O</text>
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            <dbReference type="Rhea" id="RHEA-COMP:12953"/>
            <dbReference type="Rhea" id="RHEA-COMP:12956"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.225"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mical family.</text>
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    <dbReference type="EC" id="1.14.13.225" evidence="4"/>
    <dbReference type="STRING" id="199890.A0A182P169"/>
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        <property type="protein sequence ID" value="AEPI000651-PA"/>
        <property type="gene ID" value="AEPI000651"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000651"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0120501">
        <property type="term" value="F:F-actin monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000085">
        <property type="entry name" value="protein-methionine sulfoxide oxidase Mical isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000004">
        <property type="entry name" value="protein-methionine sulfoxide oxidase MICAL2 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="F-actin_Monoox_Mical"/>
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    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <property type="entry name" value="Rossman_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF54">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF12130">
        <property type="entry name" value="bMERB_dom"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF25413">
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        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00033">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3585"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF47576">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0440">LIM domain</keyword>
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    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="4786"/>
            <end position="4801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000651-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="5160" mass="563372" checksum="C0FAAFC638374D4C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P206</accession>
    <name>A0A182P206_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aromatic-L-amino-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P206"/>
    <dbReference type="STRING" id="199890.A0A182P206"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000940-RA">
        <property type="protein sequence ID" value="AEPI000940-PA"/>
        <property type="gene ID" value="AEPI000940"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000940"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000018">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF76">
        <property type="entry name" value="FI02861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000940-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="64555" checksum="0C75009D5DD65AA0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2Q9</accession>
    <name>A0A182P2Q9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2Q9"/>
    <dbReference type="STRING" id="199890.A0A182P2Q9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001193-RA">
        <property type="protein sequence ID" value="AEPI001193-PA"/>
        <property type="gene ID" value="AEPI001193"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001193"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784:SF28">
        <property type="entry name" value="PROTEIN SICKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784">
        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001193-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="486" mass="51716" checksum="397098D3976FBFC4" modified="2016-09-07" version="1">MQSNSKALGTRVCRSSRGDHLDSVGTNPPAMEHSHVNGKSARHSSGSTVGPNGREYWGKLPEPAALGHAGNGGSTSQHGSQPPSPTSSRKDKTGSSPGQSRRSTPSSKSGSSRTKAAAGVPQSFGYIKRTNGVDHHQQQQQQQQQQQQQQGQNLLTGGRTAHVSAVPRSSKLKVSGGTQTTTADFQAKVQQHPQYRSFSLTGPGAAQLSQSVKERFGSGTHSLPKPGLDMHVFQHRMSNRASAKLTDGSLSDTQTYAEVKPDYGSYAMWLKHSNTASSRLSEGDTLDAISHGTAPSAAVAAVTGSPGSATRPHKLLHHARGETQQPHLHQQSATANSPRLNRSNSIRSTKSEKMYPSMLSRGPDVEIEPYYCLPVGTVVHPGNGGMVPWSQPTSPTPPARGFGGLLSPTHTGSAANRLTYPKKNDDVHGSQASLLSGGSSLYGSTEERQAGEVRRLKRELADARDQVMSLSSQLSTNVSIHSIWWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2R8</accession>
    <name>A0A182P2R8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="5">Epiroticus2</strain>
        </source>
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                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001344-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="91456" checksum="D6520E792F833DC2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3H2</accession>
    <name>A0A182P3H2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P3H2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001457-RA">
        <property type="protein sequence ID" value="AEPI001457-PA"/>
        <property type="gene ID" value="AEPI001457"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001457"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.22.10">
        <property type="entry name" value="Antistasin, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004094">
        <property type="entry name" value="Antistasin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011061">
        <property type="entry name" value="Hirudin/antistatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF31">
        <property type="entry name" value="PAPILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02822">
        <property type="entry name" value="Antistasin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57262">
        <property type="entry name" value="Leech antihemostatic proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51252">
        <property type="entry name" value="ANTISTASIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1492"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="10">
        <location>
            <begin position="202"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="257"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="749"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="10">
        <location>
            <begin position="809"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="863"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="934"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="1119"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="1314"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="296"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="911"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1191"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001457-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1569" mass="170949" checksum="D281BAE735D57178" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3R6</accession>
    <name>A0A182P3R6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">SLC12A transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) + chloride(in) = K(+)(out) + chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:72427"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3R6"/>
    <dbReference type="STRING" id="199890.A0A182P3R6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001551-RA">
        <property type="protein sequence ID" value="AEPI001551-PA"/>
        <property type="gene ID" value="AEPI001551"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001551"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000076">
        <property type="entry name" value="KCL_cotranspt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
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        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF73">
        <property type="entry name" value="KAZACHOC, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SLC12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01081">
        <property type="entry name" value="KCLTRNSPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="173"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="467"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="598"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="811"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="708"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="743"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001551-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="880" mass="98039" checksum="9C2E2C5B6BBD362E" modified="2017-10-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3T0</accession>
    <name>A0A182P3T0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3T0"/>
    <dbReference type="STRING" id="199890.A0A182P3T0"/>
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        <property type="gene ID" value="AEPI001566"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001566"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF26">
        <property type="entry name" value="ODORANT RECEPTOR 10A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="65"/>
        </location>
    </feature>
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            <end position="160"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001566-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="400" mass="46151" checksum="CED6F773C604B42F" modified="2016-09-07" version="1">MVAFLGASNSAADNWDLFKMQRKVLLSIGIWPPDRLVRRWYIKIFIDINMVILSICIVGEFLHAYRDGTLRETIESICPAVSRLSGFLRMVLYLMNEEKIHRVLNGVRKMIKENHPRENAITKRMTLLGQQLTFYQFLTMFFAAYFYGITPFIIMAYNWYQGQRPLEKVLPFKLALPFDPQHSLYFVLTTIFLNYASIPTINSQTGCDALFSGVCLYLNGQFQAIRLEMEALTATLDEHSLKSTAAETHRINLELKRISQRHQEIIDLVSEARTAFMPTVLLIYTATAIIMCFVCIAMLVVEGIYKLTYLPYACAELVLLFLYSYSGTIIRDSSEAIQTAAYDFPWYRFDRNTRHLIQMMMIRAQYGSNVDVPFFETSMATFSVIVRTASSYVTLMKSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4M4</accession>
    <name>A0A182P4M4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 tri-snRNP-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4M4"/>
    <dbReference type="STRING" id="199890.A0A182P4M4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001860-RA">
        <property type="protein sequence ID" value="AEPI001860-PA"/>
        <property type="gene ID" value="AEPI001860"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001860"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="639"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="792"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001860-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1019" mass="114796" checksum="84414AFE6A5CE900" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4S7</accession>
    <name>A0A182P4S7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HDGF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4S7"/>
    <dbReference type="STRING" id="199890.A0A182P4S7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001913-RA">
        <property type="protein sequence ID" value="AEPI001913-PA"/>
        <property type="gene ID" value="AEPI001913"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001913"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05834">
        <property type="entry name" value="PWWP_HRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036218">
        <property type="entry name" value="HIVI-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021567">
        <property type="entry name" value="LEDGF_IBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF70">
        <property type="entry name" value="JIL-1 ANCHORING AND STABILIZING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11467">
        <property type="entry name" value="LEDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140576">
        <property type="entry name" value="HIV integrase-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="6">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="429"/>
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    </feature>
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            <begin position="176"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001913-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="476" mass="53305" checksum="9E7291A62A874B90" modified="2016-09-07" version="1">MVASKKTFQIGDLVFAKVKGYPPWPAKITRIEKSKYNVYFYGTGETANIKKEDLFLYESSKEKFATEKMMKRKGFKEAMIQIESAINGEDPSPLAFDVAAVQSGIDDMAEAQEMSLSATEASKTTFNESHVSANSTVYNNSNVKQEILDKQYGNENISTPQPVAAQTKPSSNVKSAGNKKTANAATPTTNNGAQKKATDSPVVVPQDNSGNTEAKEITSRRGRVIKQKRFLDDEEDEDGNAHTGSPTKKKAMNFAPAKGKMAATPVATKKLNLFDKIEDERLYVLKLERQLVELNLEIKSSVKLNCADPERCVKLMDQYGNLSVTSTILKKNPNCVETMKRLRKYVGNAKAWNMDDKEKLKFDFQAQQIRQKAEQIYARFKDVLGMKDTGMPFWEWFRQEVSKFEEATKHLSHEELYLLVDEKDLNKDGQENLTKSVDASEPQETNPDNQSAENEGLEDGFEVRAASEASTVKMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P560</accession>
    <name>A0A182P560_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FAM50 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM50 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P560"/>
    <dbReference type="STRING" id="199890.A0A182P560"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002048-RA">
        <property type="protein sequence ID" value="AEPI002048-PA"/>
        <property type="gene ID" value="AEPI002048"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002048"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="4">
        <location>
            <begin position="210"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002048-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="567" mass="65589" checksum="6E17034C7D8E91F5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P589</accession>
    <name>A0A182P589_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LanC-like protein 3 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LanC-like protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P589"/>
    <dbReference type="STRING" id="199890.A0A182P589"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002077-RA">
        <property type="protein sequence ID" value="AEPI002077-PA"/>
        <property type="gene ID" value="AEPI002077"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002077"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000012">
        <property type="entry name" value="LanC-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020464">
        <property type="entry name" value="LanC-like_prot_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01951">
        <property type="entry name" value="LANCEUKARYTE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="637"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00069999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002077-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="722" mass="81609" checksum="645A2B41C4B906F4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P597</accession>
    <name>A0A182P597_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P597"/>
    <dbReference type="STRING" id="199890.A0A182P597"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002085-RA">
        <property type="protein sequence ID" value="AEPI002085-PA"/>
        <property type="gene ID" value="AEPI002085"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002085"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026085">
        <property type="entry name" value="ATF7-int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056565">
        <property type="entry name" value="Fn3_ATF7IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23210">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 7 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23210:SF26">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 7-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16794">
        <property type="entry name" value="fn3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1095"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="899"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002085-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1187" mass="127634" checksum="97C02DF48E3174F8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5A2</accession>
    <name>A0A182P5A2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA-capping enzyme</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">mRNA 5'-triphosphate monophosphatase</fullName>
                <ecNumber evidence="12">3.6.1.74</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">mRNA 5'-phosphatase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">mRNA guanylyltransferase</fullName>
                <ecNumber evidence="12">2.7.7.50</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">GTP--RNA guanylyltransferase</fullName>
                <shortName evidence="12">GTase</shortName>
            </alternativeName>
        </domain>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="12"/>
    <dbReference type="EC" id="2.7.7.50" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A182P5A2"/>
    <dbReference type="STRING" id="199890.A0A182P5A2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002090-RA">
        <property type="protein sequence ID" value="AEPI002090-PA"/>
        <property type="gene ID" value="AEPI002090"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002090"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000291">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000040">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.87.10">
        <property type="entry name" value="mRNA Capping Enzyme, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
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        <property type="entry name" value="mRNA_cap_enz_bifunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="mRNA_capping_HCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="2 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 12 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="17">
        <location>
            <begin position="34"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="18">
        <location>
            <begin position="107"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="181"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="13">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="14">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="364"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="481"/>
            <end position="483"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="551"/>
            <end position="556"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002090-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="603" mass="69770" checksum="55BDBBBC6BF3A53A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5F6</accession>
    <name>A0A182P5F6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5F6"/>
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        <property type="gene ID" value="AEPI002146"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002146-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="264" mass="28580" checksum="3556BFD28216DAD8" modified="2016-09-07" version="1">MPPPPSSRGDSSLSPVKELPSPQRNPTLDHRNMRDAEKIEPYSDEDNNPADDDDDDEDLSMMLHDEIDGDENDFAISQSHHFDMRAENRRRRRRRALLRRNSYDRIVAAGSFLPDGDLASCSVGDRAGGSGLKRPGSAPSAGEKKNNYKPSPKPQTLVQPSSHRSQAAEGQAMTNPNTGVTASTSLSNSSSTPNTSTRRSLTAASNHDSSALMGSSSRKTHHTVGRRSSNVSHSISVGSGSTTTTLSRQSNLSMIVFSVLDFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P610</accession>
    <name>A0A182P610_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RED family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P610"/>
    <dbReference type="STRING" id="199890.A0A182P610"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002351-RA">
        <property type="protein sequence ID" value="AEPI002351-PA"/>
        <property type="gene ID" value="AEPI002351"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002351"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012492">
        <property type="entry name" value="RED_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07807">
        <property type="entry name" value="RED_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="7">
        <location>
            <begin position="82"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Protein RED C-terminal" evidence="6">
        <location>
            <begin position="429"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002351-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61000" checksum="2F827755EDBC68F9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6C3</accession>
    <name>A0A182P6C3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6C3"/>
    <dbReference type="STRING" id="199890.A0A182P6C3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002471-RA">
        <property type="protein sequence ID" value="AEPI002471-PA"/>
        <property type="gene ID" value="AEPI002471"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002471"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000034">
        <property type="entry name" value="Potassium voltage-gated channel subfamily B member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000018">
        <property type="entry name" value="Potassium voltage-gated channel subfamily B member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003973">
        <property type="entry name" value="K_chnl_volt-dep_Kv2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01495">
        <property type="entry name" value="SHABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="17"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002471-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="299" mass="33791" checksum="971D958537BF6E2A" modified="2016-09-07" version="1">MSVSLFKPLLSTTYLQVIAVISILFIVLSTIALTLNTLPSLQSDHNGTSQDNPELAMVEAVCITWFTLEYVLRFSASPDKWKFFKGGLNIIDLFAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEPQTKFISIPETFWWAGITMTTVGYGDIYPTTPLGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLRDAFAKSMDLIDVIVDTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P737</accession>
    <name>A0A182P737_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P737"/>
    <dbReference type="STRING" id="199890.A0A182P737"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002739-RA">
        <property type="protein sequence ID" value="AEPI002739-PA"/>
        <property type="gene ID" value="AEPI002739"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002739"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14304">
        <property type="entry name" value="UBA2_KPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041927">
        <property type="entry name" value="UBA2_UBAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052476">
        <property type="entry name" value="UBAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057650">
        <property type="entry name" value="UBL_UBAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46738">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46738:SF1">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23326">
        <property type="entry name" value="UBL_UBAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="301"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="462"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002739-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="606" mass="66338" checksum="22B0D03CE5177277" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7S7</accession>
    <name>A0A182P7S7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yellow</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls the pigmentation pattern of the adult cuticle and larval mouth parts.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7S7"/>
    <dbReference type="STRING" id="199890.A0A182P7S7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002980-RA">
        <property type="protein sequence ID" value="AEPI002980-PA"/>
        <property type="gene ID" value="AEPI002980"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002980"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000046">
        <property type="entry name" value="Blast:Protein yellow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF12">
        <property type="entry name" value="LD43175P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002980-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="511" mass="57134" checksum="968D37774A6CFFF0" modified="2016-09-07" version="1">MTEVRRMPLAMAIIASCCITLALLPVHIVANDNLRVAYQWKEIDFEFPSEAERQEAIATKRYIPENVIPVGLEVYKKRLFLTLPRWKEGIPASLGYININETTTQSPRLHPYPSWSAHRRSSETEAPEIVSPFRIRADRCGRLWVLDTGVEELLGNTTVTSPTSLLVYDLHNDNLLRRYKFPADYLKENSFYANIAVEDTDCDDTFAYAADLGSPGLVVYSWKQQESWRVKHHYFYPDPLAGNYNITGINFQWDDGLFGIALKPQSDGYSTLYFHPLSSLNEFSVSTKVLRNQTYATDSSNYHEFKILGSRGPNGQAGVAFVDQKTGVIFYALPNLNAITCWKTSNRAYTIKSLGRVYMSTVDMVFPNDVKVDDESNLWVLSDRLHQYMYESLNRNDVNFRVLTATVKDAIQNTACDTNIKPLPDIITNLGDILRPSTSTIAPKAGSSGAWALRSYTSAIVVFSMLFTMLRMPYCIIDNGSRCINGGNAADVTAAASGRCGATVTCGSNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P888</accession>
    <name>A0A182P888_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cuticular protein (putative)</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P888"/>
    <dbReference type="STRING" id="199890.A0A182P888"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003141-RA">
        <property type="protein sequence ID" value="AEPI003141-PA"/>
        <property type="gene ID" value="AEPI003141"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003141"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF12">
        <property type="entry name" value="HL02234P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130990" description="Cuticular protein (putative)" evidence="1">
        <location>
            <begin position="19"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003141-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21541" checksum="A2C84562222A8389" modified="2016-09-07" version="1">MKRILLTILVLATQQSLGIIVSQRAGPTKRFIPLGTAEHVVSAHTFDTKNPEPWGNKQFKEITITKNVPVPYPIKVERHVAVPVKIPVPIAIHNKVPIVVERKIPVYVEKPIPVQVDRPVPYALPVEVPIFHKVAVEVPKPYPVHVPKPYPVYIKKPIFVKQKAPQQQHQKPMGKRVKKSPKQFAAMVMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8E8</accession>
    <name>A0A182P8E8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Insulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a B chain and an A chain linked by two disulfide bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8E8"/>
    <dbReference type="STRING" id="199890.A0A182P8E8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003201-RA">
        <property type="protein sequence ID" value="AEPI003201-PA"/>
        <property type="gene ID" value="AEPI003201"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003201"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04366">
        <property type="entry name" value="IlGF_insulin_bombyxin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022352">
        <property type="entry name" value="Ins/IGF/rlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13647:SF4">
        <property type="entry name" value="INSULIN-LIKE PEPTIDE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13647">
        <property type="entry name" value="INSULIN-LIKE PEPTIDE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00276">
        <property type="entry name" value="INSULINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131001" description="Insulin-like domain-containing protein" evidence="7">
        <location>
            <begin position="28"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="8">
        <location>
            <begin position="43"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003201-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="134" mass="15147" checksum="B1C5A15B469F7189" modified="2016-09-07" version="1">MRSTFIAMNSILIVAVFVLLMLNESKATSTPNSDALISQLTRSRYCGRRLTETLAFLCQGRYPMLTHYRTDYVHDQANQQRVKVEVATLPDTLPPGFPYPGAGVHRRSRRSSGGIYDECCKKSCSYVELRAYCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8Q3</accession>
    <name>A0A182P8Q3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytohesin-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P8Q3"/>
    <dbReference type="STRING" id="199890.A0A182P8Q3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003307-RA">
        <property type="protein sequence ID" value="AEPI003307-PA"/>
        <property type="gene ID" value="AEPI003307"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003307"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01252">
        <property type="entry name" value="PH_GRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000003">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF402">
        <property type="entry name" value="MIP16918P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="392"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="597"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003307-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="81949" checksum="CBC20CB16DD1D8F2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P926</accession>
    <name>A0A182P926_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Oligomycin sensitivity conferral protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P926"/>
    <dbReference type="STRING" id="199890.A0A182P926"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003430-RA">
        <property type="protein sequence ID" value="AEPI003430-PA"/>
        <property type="gene ID" value="AEPI003430"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003430"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.20:FF:000002">
        <property type="entry name" value="ATP synthase subunit O, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003430-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="248" mass="26486" checksum="A670D7B06F6138BC" modified="2016-09-07" version="1">SESVNATAAHGPTSFLCTLTKTIHRREIVLSISIDTGKMAASGKFTVLARQLSTSAAAAQLVKPPVQVFGLEGRYACALYSAASKTKALDAVEKDLKGLQSQMRSDPKMRDLLRDPTTKRNVKAAALKDVAAKVKFNAATGNLLTLLAENGRLGRLDGIINAYSLIMAAERGEVVCEVKTAKPLDDGQRKQLENALKAFLKPNQTIQLTAKVDPALIGGMVVSIGDKYVDMSVASKIKKYTDIIASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9E3</accession>
    <name>A0A182P9E3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
            <ecNumber evidence="10">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in vascular wall and kidney homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182P9E3"/>
    <dbReference type="STRING" id="199890.A0A182P9E3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003548-RA">
        <property type="protein sequence ID" value="AEPI003548-PA"/>
        <property type="gene ID" value="AEPI003548"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003548"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000075">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007950977" description="Carboxypeptidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003548-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="898" mass="101261" checksum="F0E2B1C5473FAA37" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9F8</accession>
    <name>A0A182P9F8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182P9F8"/>
    <dbReference type="STRING" id="199890.A0A182P9F8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003563-RA">
        <property type="protein sequence ID" value="AEPI003563-PA"/>
        <property type="gene ID" value="AEPI003563"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003563"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000013">
        <property type="entry name" value="Carboxy-terminal domain RNA polymerase II polypeptide A small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040078">
        <property type="entry name" value="RNA_Pol_CTD_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01124">
        <property type="entry name" value="C0.1:_RNA_Pol_CTD_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="7">
        <location>
            <begin position="65"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="4">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003563-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="281" mass="31943" checksum="66B9ABB60BA1EA2F" modified="2016-09-07" version="1">FLCLLPVNNVDRLKPPNRGFLETLFCCWRNGRTKSNQSGTPIDGSITPPPIQGQPGYLLPQVRPSDMYKKCMVIDLDETLVHSSFKPIPNADFIVPVEIDGTVHQVYVLKRPHVDEFLKKMGELYECVLFTASLAKYADPVADLLDQWNVFRARLFRESCVFHMGNYVKDLNKLGRDLQKIVIVDNSPASYIFHPDNAVPVKSWFDDINDSELLDLIPLFEKLSKVDSVYSVLCNSSSLSQLPTSMSHHNQQDLQQSQQQSQQQQQQQQQLQSNSSDSNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9U5</accession>
    <name>A0A182P9U5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9U5"/>
    <dbReference type="STRING" id="199890.A0A182P9U5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003699-RA">
        <property type="protein sequence ID" value="AEPI003699-PA"/>
        <property type="gene ID" value="AEPI003699"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003699"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003699-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="265" mass="30214" checksum="52ED6ED989715385" modified="2016-09-07" version="1">MASGFVSETELAEARRKRQEEWEKVRTADQPIEAPEDEYDPRSLYERLQEQKQKKDSEFEEAHKLKNMIKGLDDDEVEFLDLVDKNRMQAERQAHLEEQKELNEFRAKVATLQEKRLDEQIQQQVSVPKPTKTALTSTRPSQKQILAGVVRKRKLEPENEPKEANESPEKRLSTSTKHTNGGTEKLAEKATSPSSLTSVAKNEVASKPKGQNLAMRVIGILPGMGPYNDDEDDSDSDNSSEDSELDNSQEYDWIGRKIRKNCDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA25</accession>
    <name>A0A182PA25_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">p53 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the p53 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PA25"/>
    <dbReference type="STRING" id="199890.A0A182PA25"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003779-RA">
        <property type="protein sequence ID" value="AEPI003779-PA"/>
        <property type="gene ID" value="AEPI003779"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003779"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08367">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011615">
        <property type="entry name" value="p53_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002117">
        <property type="entry name" value="p53_tumour_suppressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447">
        <property type="entry name" value="CELLULAR TUMOR ANTIGEN P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447:SF16">
        <property type="entry name" value="P53 PROTEIN LONG FORM VARIANT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00870">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00386">
        <property type="entry name" value="P53SUPPRESSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="p53 DNA-binding" evidence="13">
        <location>
            <begin position="93"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="277"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602117-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003779-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="445" mass="49255" checksum="B8A202B36CDEEC52" modified="2016-09-07" version="1">MDLLNPEMFGDLNTGSYQSAEDCQTLYRMNTNELLPAQGCALEDYVFSELLENAGVAKMEFIKYETDTKPLVMEAAAGGLSPTHHQKIPALDDFTNPQQVFTVGVSGKPCSASSWCYSNELKKLFVKKKTPVTFDVTYTQPSDCNLKLRIMLVYSNTQYAYNVITRCQDDISKDNAKDYAHKDHVVRCLNPGASFTGRENGLNFEDRLAVLVELNHTGTQNQLMQQTVPVSLEFLCQNSCPTMERRATTLLFTVENEHGTLLGRKSVSVKICSCPKRDMEKDEKKTSGGGRENNKNKRKHANDVVSSSDQPPRKVTRQASLDMKSATSNSSNHSAAVARESAVAVPAAASTMGQIKREPSFTPLGYSLSNLSNSSSSNAIDNDSSAVVLTLRLPDFKCASEVAMYAYKHLSSILIGCKDDKEKNRYAQYLLHCRRVGSKYSSSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA73</accession>
    <name>A0A182PA73_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PA73"/>
    <dbReference type="STRING" id="199890.A0A182PA73"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003827-RA">
        <property type="protein sequence ID" value="AEPI003827-PA"/>
        <property type="gene ID" value="AEPI003827"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003827"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF76">
        <property type="entry name" value="PROTEIN NUBBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="10">
        <location>
            <begin position="255"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="356"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="358"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="414"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003827-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="481" mass="51194" checksum="BB282F01643AB986" modified="2016-09-07" version="1">MDEDAGFVAYDDIDSDRDDGSDRENLSSPIPNERPERTTPLNLITDSSRRTPSPPVASGVPGGGLGVALAALQNHLPLSSLFLQNQLGLGLSGQDIGMLQQALQAQQASLQQQLQQYMLLQVQGSAASANGNPAAAATAQAQAAAQFLMQNQVQQAVAQLQALQKQQQLKPTSSTPTPGATATSSPLHSPSGSPGLHHHSTQTGAMLGASQTTPPNVSQLNVGGILTPSTPGSGAHTPQLQKHSAAPRALEPSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLEDADSSISNPGGRIFSPAALSNTMATPETMGRRRKKRTSIETSVRVALEKAFLVNCKPTSEEISTLADNLCMEKEVVRVWFCNRRQKEKRINPPNGMDSPTHSSASGELFPASLVPGLSSPSSASGGGGGGVHLYAPHLQQQHQQSQHHSGSIKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAA4</accession>
    <name>A0A182PAA4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PHD finger protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">PHD factor 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Component of SIN3 complexes. Interacts with SIN3A in a complex composed of HDAC1, SAP30 and SIN3A. Component of the SIN3B complex, which includes SIN3B, HDAC2 or HDAC1, PHF12 and MORF4L1; interacts directly with all subunits. Interacts with TLE5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAA4"/>
    <dbReference type="STRING" id="199890.A0A182PAA4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003858-RA">
        <property type="protein sequence ID" value="AEPI003858-PA"/>
        <property type="gene ID" value="AEPI003858"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003858"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15533">
        <property type="entry name" value="PHD1_PHF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000154">
        <property type="entry name" value="PHD finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000164">
        <property type="entry name" value="PHD finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.60">
        <property type="entry name" value="PHD finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042163">
        <property type="entry name" value="PHF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031966">
        <property type="entry name" value="PHF12_MRG-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038098">
        <property type="entry name" value="PHF12_MRG-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309:SF1">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16737">
        <property type="entry name" value="PHF12_MRG_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="258"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="18">
        <location>
            <begin position="708"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="428"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="495"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003858-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="903" mass="100208" checksum="FACFBF7E3A4B4A36" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAH6</accession>
    <name>A0A182PAH6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cilia- and flagella-associated protein 43</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PAH6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003930-RA">
        <property type="protein sequence ID" value="AEPI003930-PA"/>
        <property type="gene ID" value="AEPI003930"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003930"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25828">
        <property type="entry name" value="CC_Cfap43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1273"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1440"/>
            <end position="1478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003930-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1564" mass="180563" checksum="26CA2772433BB2FA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAU3</accession>
    <name>A0A182PAU3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAU3"/>
    <dbReference type="STRING" id="199890.A0A182PAU3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004048-RA">
        <property type="protein sequence ID" value="AEPI004048-PA"/>
        <property type="gene ID" value="AEPI004048"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004048"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="898"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004048-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="925" mass="99399" checksum="F187ACDDA44D9601" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB83</accession>
    <name>A0A182PB83_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PB83"/>
    <dbReference type="STRING" id="199890.A0A182PB83"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004188-RA">
        <property type="protein sequence ID" value="AEPI004188-PA"/>
        <property type="gene ID" value="AEPI004188"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004188"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131083" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004188-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7594" checksum="C3851E22441CFF8C" modified="2016-09-07" version="1">MGLPRIRSLVAPLCFLLLASSWLVSDVDCAKKAAASAPAAAPEATIEEVSAKQLERLLEDKDYVAVYWCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBM1</accession>
    <name>A0A182PBM1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PBM1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004326-RA">
        <property type="protein sequence ID" value="AEPI004326-PA"/>
        <property type="gene ID" value="AEPI004326"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004326"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="775"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1162"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1208"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1362"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1422"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1463"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1540"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1856"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1978"/>
            <end position="1997"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
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        </location>
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            <begin position="257"/>
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        </location>
    </feature>
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        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="398"/>
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        </location>
    </feature>
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        <location>
            <begin position="634"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="825"/>
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        </location>
    </feature>
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        <location>
            <begin position="1309"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1429"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1549"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1856"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1876"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="1934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="1964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1984"/>
            <end position="1995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004326-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2086" mass="220351" checksum="0765C29C9C4CC3F5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBM5</accession>
    <name>A0A182PBM5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Drebrin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBM5"/>
    <dbReference type="STRING" id="199890.A0A182PBM5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004330-RA">
        <property type="protein sequence ID" value="AEPI004330-PA"/>
        <property type="gene ID" value="AEPI004330"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004330"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0045773">
        <property type="term" value="P:positive regulation of axon extension"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098974">
        <property type="term" value="P:postsynaptic actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_Abp1_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Drebrin-like protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000046">
        <property type="entry name" value="Drebrin-like protein isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADF-H"/>
    </dbReference>
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        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035717">
        <property type="entry name" value="Drebrin-like_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="368"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004330-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47596" checksum="5BDBC3B7001357F7" modified="2016-09-07" version="1">MSVDLQKHRDAIVGAWKSVCDRKSATNWALFGYEGQTNVLKLQETGEDGISELAAELNSGKIQYAFLRVDNSETGIAKFVFINWQGEGAPIARKGTCAKHVRDVTGLLHGAHITVHATNEDDVEEARILEKLQKVVVNDFKVKDYSQAIDSPKPVGTNYSRVNPTKEINPAERDEFWRKEEEEEKHRLQAEYERKLNETVLLEEERRRREEREFEKREGVAVGGASIGSASPVSPDRSYARQASDQSKTEREREIKQVVEASAKVSSAKARFLNSTAQLSPTHIQAEVAQELTEAPFSPTASFEERSIINELKAELESERQNGTDTPPGLAADPMPVSEPVVSPEEVPEVATGQYFDPNATIDLSDEDNMIRARALYDYQAADDSEISFDPDDIITHIDQIDEGWWQGLAPDGTYGLFPANYVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBY5</accession>
    <name>A0A182PBY5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBY5"/>
    <dbReference type="STRING" id="199890.A0A182PBY5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004441-RA">
        <property type="protein sequence ID" value="AEPI004441-PA"/>
        <property type="gene ID" value="AEPI004441"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004441"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="796"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004441-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="843" mass="93589" checksum="038D4F45ABB11162" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCU1</accession>
    <name>A0A182PCU1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCU1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004746-RA">
        <property type="protein sequence ID" value="AEPI004746-PA"/>
        <property type="gene ID" value="AEPI004746"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004746"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004746-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="79" mass="8571" checksum="2DB169E35B888715" modified="2016-09-07" version="1">MWERHIGGEGWSYYCDCYPGFSGPDCGDGPLCKDANVCENGGTCKHIGDNAIICICPAGFKGKRCEINEYDEVTGKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCY3</accession>
    <name>A0A182PCY3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCY3"/>
    <dbReference type="STRING" id="199890.A0A182PCY3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004788-RA">
        <property type="protein sequence ID" value="AEPI004788-PA"/>
        <property type="gene ID" value="AEPI004788"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004788"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000423">
        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000512">
        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001146">
        <property type="entry name" value="Sodium/phosphate transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF415">
        <property type="entry name" value="AT30085P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="733"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="808"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="832"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="864"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="898"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="7"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="495"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004788-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="936" mass="103313" checksum="BE61E047BD128645" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD78</accession>
    <name>A0A182PD78_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PD78"/>
    <dbReference type="STRING" id="199890.A0A182PD78"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004883-RA">
        <property type="protein sequence ID" value="AEPI004883-PA"/>
        <property type="gene ID" value="AEPI004883"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004883"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004883-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="489" mass="54515" checksum="0DC081DE344CCD0D" modified="2016-09-07" version="1">MRYANKLEFKEKTHEVSMTAQRLVQRMKKDSIHSGRRPSGLCGAALLLAARMHDFSRTPNDIVRIVKIHESTLRKRLFEFGETPSSALTVDEFMAVDLEAEQDPPAFKAARKRDKERLQKLEEQTIEFNQLQAEIDAALDREMTRLGKKRKIKHMDFDELQETGKFIEECTMDVISEVIEEDPLAGGGKKDGANVSKILIPEGMQPDLRAMCTNNDKDRQNGEASGSSLHTEDNIGPDELGEGLDDEEITGYIMTEEEAHTKSKQWVKLNEEYLRDMQIKEERAAKEREEGKPEKKKRRTVKKKMLGPSSSAREAIEMILQEKKISSKINYDILKTLTDGGDGVGSSTSAASSTLTGQPVEEKGEVKGEIIPTNGLLSPTRGVKQEKKSSDTPLADVAGRSSLKPTPNFGASSRRKHTVQATLPVVSAGAEEESTKVTEDGTTKTGQDDDYEDEGDGEPEPEPEPEHKSLADMLNTGDDDDYYGYEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE13</accession>
    <name>A0A182PE13_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PE13"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005168-RA">
        <property type="protein sequence ID" value="AEPI005168-PA"/>
        <property type="gene ID" value="AEPI005168"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005168"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026780">
        <property type="entry name" value="PNRC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15405">
        <property type="entry name" value="PROLINE-RICH NUCLEAR RECEPTOR COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005168-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="275" mass="28847" checksum="FA60F8F710A0CEAE" modified="2016-09-07" version="1">MTNSHNRNGRNAGSGNHAERYFHNHSPQQLSPSTQQQQQQQQHGGNIGSNGKQQRGGGGRSQRSPSANYFRSILSSANTIPIVQQQQHQQQRQPSYSPTGGRGGGRHSNNSSSSNSFNQRSSPNNSSFPMMLSSPMGTGSAAGPVSGSPPNFSHFAGSKCYDAPAPTALPKPPVHWTTVGGNGSSSSTTNITSSSFSSMMMMMANGGDVGGGSSATGATRKGAAGSSSINVGLKQQYHSQQQHQQQQTRLRTKAMKSCASAAAKASNLEVDPTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE48</accession>
    <name>A0A182PE48_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="12">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A182PE48"/>
    <dbReference type="STRING" id="199890.A0A182PE48"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005203-RA">
        <property type="protein sequence ID" value="AEPI005203-PA"/>
        <property type="gene ID" value="AEPI005203"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005203"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="793"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="859"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="14">
        <location>
            <begin position="422"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005203-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="939" mass="106264" checksum="0078E6A73B06E934" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE95</accession>
    <name>A0A182PE95_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase-like hydrolase domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PE95"/>
    <dbReference type="STRING" id="199890.A0A182PE95"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005250-RA">
        <property type="protein sequence ID" value="AEPI005250-PA"/>
        <property type="gene ID" value="AEPI005250"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005250"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005250-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32692" checksum="701A55C3627F8D91" modified="2016-09-07" version="1">MHHLRNNLSRFRLVTFDVTDTLLEYAVRPERHYAQVINAVLEPRLGLTVREEQVARSFGRCFRTLKQQHPNFGAGRKAQQEEGWHWWWRTLVEQVVVDAAAAAAAPTVPERAAVPPALLRAIAEQLIDDYTHDGQRVCWRQRPGASELLAQMRDPARTLGIVSNFDPRLEIILRNNGVAPGQVVDFVVTSYEAGVEKPDPAIFESALRRANGLTGAGTGRKEIAPHEALHIGNLCREDYGGAREAGWCAVLVNVPPNDKNRKLLESIPSEHVFTGLPELQRRLESPTRLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEI1</accession>
    <name>A0A182PEI1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PEI1"/>
    <dbReference type="STRING" id="199890.A0A182PEI1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005336-RA">
        <property type="protein sequence ID" value="AEPI005336-PA"/>
        <property type="gene ID" value="AEPI005336"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005336"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000008">
        <property type="entry name" value="histidine--tRNA ligase, cytoplasmic isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="308"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005336-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="478" mass="54021" checksum="9BBD6FBFE0199BC1" modified="2016-09-07" version="1">MKKGNITLSSYSAEGAISSHKVFDSKSIKEPVLLKTPKGTRDYGPKAMALRQRLLDQVVGVFRKHGAETIDTPVFERKEVLAGRYGDEAKLIYELKDQGGELLALRYDLTVPFARYVGMNNLSNVKRYHIAKVYRRDNPQLARGRYREFYQCDFDIAGAYDPLLPDTECLKVMCEILLEVGVGEFVVKLNHRKLLDGMMEACGVPTEQFRSVCSAIDKLDKAPWDEVRQELVEQKGLAEETVDRIREYVTLQGGLELVNRLADDEKLKCVPSAKEALNDVRLLFEYCNIFQVADRISFDLSLARGLDYYTGVIYEAVLVGDDKQVTGGGSVAGGGRYDNLVGSFKPNRKQQIPCVGVSIGVERLFSIIEARTVDERSRTTETEVYVASAHRGLHLRRLEILNRLWEAGIKAEHSYRMIPKLLVQLQYCEERRIPYAVIVGEGELARGVVKLREVATRNEEELSLDTLIETIRSRRCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PET5</accession>
    <name>A0A182PET5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase K family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PET5"/>
    <dbReference type="STRING" id="199890.A0A182PET5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005440-RA">
        <property type="protein sequence ID" value="AEPI005440-PA"/>
        <property type="gene ID" value="AEPI005440"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005440"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026770">
        <property type="entry name" value="RNase_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31733">
        <property type="entry name" value="RIBONUCLEASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005440-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="95" mass="10589" checksum="01B63F17D0130D30" modified="2016-09-07" version="1">MPICGPKLSLCGLIISVWGIIQLLLMGVFYYINSVALIEDLPLEEHYKTPQEFYAAADVAYSQNAYNCWIAACIYVLTLVISVQQFHANSRSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEW2</accession>
    <name>A0A182PEW2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEW2"/>
    <dbReference type="STRING" id="199890.A0A182PEW2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005467-RA">
        <property type="protein sequence ID" value="AEPI005467-PA"/>
        <property type="gene ID" value="AEPI005467"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005467"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02685">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.30">
        <property type="entry name" value="MITD, C-terminal phospholipase D-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052817">
        <property type="entry name" value="MIT_domain_contain_protein1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032341">
        <property type="entry name" value="MITD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038113">
        <property type="entry name" value="MITD1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21222">
        <property type="entry name" value="MIT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21222:SF1">
        <property type="entry name" value="MIT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16565">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005467-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="241" mass="28044" checksum="1B1991D9E376B8A3" modified="2016-09-07" version="1">MASSQMMAVTLLTRAIEYDVVGRKLEALKLYEDGIESLLKESKAETDPKRKQHFQTKIVEYMNRAEQVKELVTRWKSKGVISDRIHIVEGATGYSYSRIFGKYFNDSVHEILLEEPYVREHHQVCNLVMFCELAVSSCRNLKYIQLSTVKEGKNNDEQGRAFETLKQSLQKQAIKFVVEYSEHMHDRQVILSNGYVIKIGRGLNYFKPSPSKYCLGAFNYHFRECRETNVDVFYCPENNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF56</accession>
    <name>A0A182PF56_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PF56"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005561-RA">
        <property type="protein sequence ID" value="AEPI005561-PA"/>
        <property type="gene ID" value="AEPI005561"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005561"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005561-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="133" mass="15288" checksum="53C947FF8BFED525" modified="2016-09-07" version="1">MAESNKTNARQQFIDAYTALVSGISTTRFDEYKDFFANEDDYALAIQEFRNGLQEALLAKVNRLWDESDIDGNVEILENLKIKAAGNATKMWRPTGKSVSEQVRPLVVNKLKTSLKFYQYQLGFQKDRTEVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFH9</accession>
    <name>A0A182PFH9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PFH9"/>
    <dbReference type="STRING" id="199890.A0A182PFH9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005686-RA">
        <property type="protein sequence ID" value="AEPI005686-PA"/>
        <property type="gene ID" value="AEPI005686"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005686"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08033">
        <property type="entry name" value="LARP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12289">
        <property type="entry name" value="RRM_LARP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000158">
        <property type="entry name" value="La ribonucleoprotein domain family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034880">
        <property type="entry name" value="LARP6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12901">
        <property type="entry name" value="SUZ-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="289"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="387"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="8">
        <location>
            <begin position="806"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005686-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="96233" checksum="076E4FF1AD4D344B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFP6</accession>
    <name>A0A182PFP6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PFP6"/>
    <dbReference type="STRING" id="199890.A0A182PFP6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005753-RA">
        <property type="protein sequence ID" value="AEPI005753-PA"/>
        <property type="gene ID" value="AEPI005753"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005753"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000002">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000004">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032006">
        <property type="entry name" value="TMIE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16038">
        <property type="entry name" value="TMIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005753-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="52534" checksum="480BF65D007FB796" modified="2016-09-07" version="1">MILLEINNRIVEETLTVKFKNAIAGNKAESIDVTVADFDGVLFHISNINGDKTKVRTSISLKFYKQLQEHGADELLKREYGDLLIAPEDGYNVSVLVDLENIPENWEETVRKIGLLKRNCFASVFEKYFDFQSQGEGEGEGQKRAVINYRNDETMYVEAKPDRVTVVFSTIFRDEDDVVLGKVFMQELREGRRASHTAPQVLFSHREPPLELANTGARVGENIGYVTFVLFPRHTAKETRDNTINLIHMFRDYLHYHIKVLFESVHPLPNAGKDDGVFKGAQPCSAGAKNYGKENNIRPNIHQKRMILEHVGRLVVKCRGKKVESLQKRNGMMGDEMSVEQEAEAILEAETSFGMRVWHLLFLSCGSVLGVVIMLCCCIRFRIPRTKQDIEADYHRKKLTRKFRERLDCMNNADIDEMDLIKALERVREDYVAEQEKQASKEVAENKDNQAIVTVCENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH34</accession>
    <name>A0A182PH34_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PH34"/>
    <dbReference type="STRING" id="199890.A0A182PH34"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006243-RA">
        <property type="protein sequence ID" value="AEPI006243-PA"/>
        <property type="gene ID" value="AEPI006243"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006243"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006243-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="338" mass="37276" checksum="5FA8EFA1872D398A" modified="2016-09-07" version="1">MSNNKQTLVISAVGIFVCYFYFAILQEKITRGRYGDALQEDGSRGERFTYMLALVGVQCVCNWVFAKALLTITPQPEDGTPKVYYASSALTYLLAMISSNMALRWVAYPMQVVAKAAKPIPVMLLGVLIGRKSYTLQKYFFVLLIVVGVVLFMYKDGKANTGAALEHETIGQLLLIMSLLMDGLTGAVQERMRAHSSPSAQHMMLAMNGWSAMIVSVGLLVTGEGKAFIMFASRYPELFTHLTLLALTGALGQLFIFMMVSSFGALACSVVTTTRKFFTVLFSVLFFGNVLTGRQWIGAILVFCGLFADMFFGRKPAPVSKVEKEKDKIESELLSAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH36</accession>
    <name>A0A182PH36_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PH36"/>
    <dbReference type="STRING" id="199890.A0A182PH36"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006245-RA">
        <property type="protein sequence ID" value="AEPI006245-PA"/>
        <property type="gene ID" value="AEPI006245"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006245"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006245-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="827" mass="90212" checksum="CC04328E14BF5008" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH56</accession>
    <name>A0A182PH56_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PH56"/>
    <dbReference type="STRING" id="199890.A0A182PH56"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006265-RA">
        <property type="protein sequence ID" value="AEPI006265-PA"/>
        <property type="gene ID" value="AEPI006265"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006265"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006265-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="236" mass="27254" checksum="7661AD2AA5ABD5DA" modified="2016-09-07" version="1">MIKVHAPTTAIPTDKRYKCEQCGRMFNFLAQLKIHLDCVHGSKDVRCNVCNKYFNLKSFEAHKRTAHTDQMLMCEHCPKLFKSSGALKIHARSHDDSLAQFTACKLCNKQMKHANLKKHMTSQHSEDGPVSCELCGKSFRSMFHMKRHQKNTCKATIDSRPHKCEVCGKGFHTKLTMVEHMTTHTRTNQYQCAFCFKSFGYISNLQKHRKKAHPLEWQEIQARPEEGIASVIMVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHQ0</accession>
    <name>A0A182PHQ0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="6">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PAN3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHQ0"/>
    <dbReference type="STRING" id="199890.A0A182PHQ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006460-RA">
        <property type="protein sequence ID" value="AEPI006460-PA"/>
        <property type="gene ID" value="AEPI006460"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006460"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5160:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pan3 C-terminal knob" evidence="8">
        <location>
            <begin position="594"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="6">
        <location>
            <begin position="642"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="603"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="419"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="499"/>
            <end position="500"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006460-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="739" mass="81098" checksum="A441F8C70579E885" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIB1</accession>
    <name>A0A182PIB1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIB1"/>
    <dbReference type="STRING" id="199890.A0A182PIB1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006673-RA">
        <property type="protein sequence ID" value="AEPI006673-PA"/>
        <property type="gene ID" value="AEPI006673"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006673"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF233">
        <property type="entry name" value="CARBONIC ANHYDRASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006673-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="347" mass="39708" checksum="CFF6F747039DDFE8" modified="2016-09-07" version="1">MSQTSLPPVPDEQRSTTSTTSLQNEALVWSLAPTEAYRPAPIDINVARSVQLELEPLRWTGYESLPASVKLTNTGETVILSARWDGDTCPSLEGGPLAGRYRFSQLHFHWGRTALDGSEHTIDGYRLPLELHVIHFADRYADQDAAQTEPGGVLCLVYLFNLKSNPSRFLEPVVRGLERVLLPEAHTKLEPFPLIELFHAFTDEYFLYWGCTRNGPQLTPMLWLLSRVQEPLDFRQLKQFNRLLDRRMRPRYSLQPSDTVARSASQVQHLFHVNPRTPMAVSTLMVEPPQKFAQTRWLVDRLQPIDWSSPDACRQYVRTVREELARKKRTSDGEVRCPDRDATSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJS9</accession>
    <name>A0A182PJS9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tonsoku-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tonsoku family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PJS9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007194-RA">
        <property type="protein sequence ID" value="AEPI007194-PA"/>
        <property type="gene ID" value="AEPI007194"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007194"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052311">
        <property type="entry name" value="MMS22L-TONSL_complex_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="638"/>
            <end position="670"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="527"/>
            <end position="561"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="719"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="879"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="996"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="743"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="888"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="921"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1009"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007194-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1532" mass="172640" checksum="3E33DA1BE3FEAF00" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK53</accession>
    <name>A0A182PK53_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">N-terminal methionine N(alpha)-acetyltransferase NatC</fullName>
            <ecNumber evidence="13">2.3.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N-acetyltransferase MAK3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NatC catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-isoleucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50524"/>
            <dbReference type="Rhea" id="RHEA-COMP:12713"/>
            <dbReference type="Rhea" id="RHEA-COMP:12714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133379"/>
            <dbReference type="ChEBI" id="CHEBI:133380"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-tryptophyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12724"/>
            <dbReference type="Rhea" id="RHEA-COMP:12725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133386"/>
            <dbReference type="ChEBI" id="CHEBI:133387"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.256" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A182PK53"/>
    <dbReference type="STRING" id="199890.A0A182PK53"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007319-RA">
        <property type="protein sequence ID" value="AEPI007319-PA"/>
        <property type="gene ID" value="AEPI007319"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007319"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000010">
        <property type="entry name" value="Putative N-alpha-acetyltransferase 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="301"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007319-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="450" mass="48399" checksum="10465B1AD9A9E9EB" modified="2016-09-07" version="1">MDVIGPEDGRSTETATSGKLTNGNATSTEQNATAVAVAAAIAGSGSGKRKKAKRKNKAKNSLTEPELTGDENATIFSPDTIQTGKPLKAVQAAKEVQQRSAAVVNSNCNSTSSNHSISHSNGLPEGELVSIDAISKKLEQCVQIGRNGLTNGLPNHGNGPSDGASSETAGGGLTSPPVNDKGTAAGRKKNRSRQAKKGHANTEEVYAENGNVPKGKEEVKSQPTAATAAAFPQTGTGSVQKPTVEGNAIVVKQEAIKSEQQPSVPNAATVVQGADAATTSACNNNLLPTVESKPALTPMEISYRVYESERQMPAIMALIQKDLSEPYSIYTYRYFIHNWPKLCFLALHRDTCVGAIVCKLDIHRQETRRGYIAMLAVDKDYRKLKIGTTLVQKAIQAMVEDHADEVVLETEITNQPALRLYENLGFVRDKRLFHYYLNGVDALRLKLWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLK7</accession>
    <name>A0A182PLK7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLK7"/>
    <dbReference type="STRING" id="199890.A0A182PLK7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007827-RA">
        <property type="protein sequence ID" value="AEPI007827-PA"/>
        <property type="gene ID" value="AEPI007827"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007827"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08317">
        <property type="entry name" value="Death_ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2660:FF:000001">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040745">
        <property type="entry name" value="Ankyrin_UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF141">
        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17809">
        <property type="entry name" value="UPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Death" evidence="6">
        <location>
            <begin position="229"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="549"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="691"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="924"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1158"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="697"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="943"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="955"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007827-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1183" mass="132698" checksum="546B54056E115E60" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMK5</accession>
    <name>A0A182PMK5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMK5"/>
    <dbReference type="STRING" id="199890.A0A182PMK5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008179-RA">
        <property type="protein sequence ID" value="AEPI008179-PA"/>
        <property type="gene ID" value="AEPI008179"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008179"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF1">
        <property type="entry name" value="LP10272P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008179-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="126" mass="13674" checksum="2C9AF556A88BE0F5" modified="2016-09-07" version="1">MDCLWCNACVGEAFVCQIAFGNVQNCGRGNILHTAGHEWVGDADSDIGGRLGLWQVCQKDDLTDSCTGRLEELLEMQSIAFQVATVFCGLAVATSVLAICCLLLMVFMKSTTVFHICGWMQMLSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMT8</accession>
    <name>A0A182PMT8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="STRING" id="199890.A0A182PMT8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008262-RA">
        <property type="protein sequence ID" value="AEPI008262-PA"/>
        <property type="gene ID" value="AEPI008262"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008262"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
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        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <location>
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        <location>
            <begin position="642"/>
            <end position="797"/>
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        <location>
            <begin position="75"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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        <location>
            <begin position="1146"/>
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            <begin position="1303"/>
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            <begin position="96"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008262-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1370" mass="150013" checksum="F89443AE3E944D34" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN20</accession>
    <name>A0A182PN20_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tal-like protein AA</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AEPI008344-PA"/>
        <property type="gene ID" value="AEPI008344"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008344-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="7345" checksum="98CF11400445751B" modified="2016-09-07" version="1">MNRKLDPTGMYRRPGSGAHSFQRSTLHHHQQLQNHQRMPHHHQQQQQHQVKCHYLDPTGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ05</accession>
    <name>A0A182PQ05_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bystin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQ05"/>
    <dbReference type="STRING" id="199890.A0A182PQ05"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009035-RA">
        <property type="protein sequence ID" value="AEPI009035-PA"/>
        <property type="gene ID" value="AEPI009035"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009035"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009035-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="56910" checksum="19792AA9D7FA4856" modified="2016-09-07" version="1">MGKSKAHRIKKIAAPKSFIEEQVNDGRVSKKSKQLKIRLRAEESNYVDSKTSKKILKEARKQQAEFNLLDSSFGPTPAESSSVKKRHRLDDRASSDESDLEDREEADINGDNLFDDIKISEEDERALQMFQNKDGTKTRTLADIILEKMTEKQTEIQTQFSDNASLKLDDIDPNVRAMYKGVRDVLKRYRNGKIPKAFKLIPKLRNWEQFLYITEPQQWSAAAMFQATRLFSSGLTQHMAQRFYNLVLLPRVRDDLAEYGRLNFYLYRSLKKALFKPAAFMKGIVLPLLEAGDCTLREAIIIGSVISCTSIPVLHTAACLLKICEMEYSGACSVFIRIILDKRYALPYRVVDAAVFHFLKFEQDKRELPTLWHQALLTFAQRYKNDISSEQRDALLHLLKKKTHHKITPEIRRELQAAKCRDVEIGQSLALEGEVEFQEDNDYTPMDDDDMGHASQKPSKSGTGQQVDEEMDSDDDDEDDGESDDDDDDDDDEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQT3</accession>
    <name>A0A182PQT3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQT3"/>
    <dbReference type="STRING" id="199890.A0A182PQT3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009314-RA">
        <property type="protein sequence ID" value="AEPI009314-PA"/>
        <property type="gene ID" value="AEPI009314"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009314"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF92">
        <property type="entry name" value="ACYL-COA DESATURASE 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="14">
        <location>
            <begin position="139"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009314-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="252" mass="28717" checksum="0A60C55C3D6DEE99" modified="2016-09-07" version="1">MGADSQTKTILCAKTPELIETAIADRKPEQSQTDPQGCAPTAESLAAELSQSDSTLSGAQFEKALQTCSNVVHEAEVDRKLKEIGSATPILPSEIGTDFNFKREIVWKNVVGFLLLHICGWVGLHLAFWRYCDYRTTLYTLWLMYASGQGVTMGAHRLWSHRAFKAKLWLRIILLWMHTLAGQNCLYVWVRDHRQHHKFSDTDADPHNANRGFFFSHIGWLLSKKHPKVIEYGKKIDMSDLEADPLIMFQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR69</accession>
    <name>A0A182PR69_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PR69"/>
    <dbReference type="STRING" id="199890.A0A182PR69"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009451-RA">
        <property type="protein sequence ID" value="AEPI009451-PA"/>
        <property type="gene ID" value="AEPI009451"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009451"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000478">
        <property type="entry name" value="GG16802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="6">
        <location>
            <begin position="90"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009451-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="307" mass="34828" checksum="C5963EF6BC4C0F0E" modified="2016-09-07" version="1">MSCNMEDLNWSDARNMLRKWRDENERKSDDVMQLWDNILSSKQSKLGNERHLVLEQVIIAALDCNRIETAEHCVSILSAEFPGSLRIQKYRSMLLEALERYDDALDELEQIIRKDETNAAPRKRKVAILKTQGRTAEAIKELCDYMKIFMSDQEGWHELCNLYLAEGEYAKAAFCMEELLLHNPHSHLIHQRLADIRYTMGGLDNIEMAKTHYCKAVKLNVNNLRALYGLFLCCGHISNSKAVVGKRKEAQKLAQWAMAQIQSRTHSASKDTKGAIKTGKGPAAACEDELQALEQAFGGLDVAKVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRQ3</accession>
    <name>A0A182PRQ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Inwardly rectifying k+ channel</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PRQ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009638-RA">
        <property type="protein sequence ID" value="AEPI009638-PA"/>
        <property type="gene ID" value="AEPI009638"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009638"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000078">
        <property type="entry name" value="Putative Inward rectifier potassium channel"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF113">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="777"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1222"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1304"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="15">
        <location>
            <begin position="151"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="16">
        <location>
            <begin position="303"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="15">
        <location>
            <begin position="661"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="16">
        <location>
            <begin position="813"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="15">
        <location>
            <begin position="1187"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="16">
        <location>
            <begin position="1340"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1130"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1131"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1144"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009638-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1562" mass="179127" checksum="992F2B29AA57F377" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRY6</accession>
    <name>A0A182PRY6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Arrowhead</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRY6"/>
    <dbReference type="STRING" id="199890.A0A182PRY6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009721-RA">
        <property type="protein sequence ID" value="AEPI009721-PA"/>
        <property type="gene ID" value="AEPI009721"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009721"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09373">
        <property type="entry name" value="LIM1_AWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09379">
        <property type="entry name" value="LIM2_AWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000023">
        <property type="entry name" value="LIM homeobox 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000006">
        <property type="entry name" value="LIM homeobox transcription factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF127">
        <property type="entry name" value="LIM_HOMEOBOX PROTEIN AWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 12" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="144"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009721-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29768" checksum="8FB0B017870168C3" modified="2016-09-07" version="1">TEFKTCGSCAEPITDRYIFEVNGSAWHGSCLRCTVCFCPLERQVSCYLRDGDMYCKSDYIKKFKTSCAKCSRAISATDWVRRAREYVFHLACFACDSCGRQLSTGEQFAICEERVLCKTHYMELIDDGTASSEDGCDADGSGKNKTKRIRTTFTEEQIQILQANFQVDSNPDGQDLERIALATGLSKRVTQVWFQNSRARQKKHVHVPRAQDLFSGMRSDLNNNNSCSSSNSNDGPPAHHLGGIGPEDCVLGKTPIFNSHGFINLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSC2</accession>
    <name>A0A182PSC2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein uL2 RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PSC2"/>
    <dbReference type="STRING" id="199890.A0A182PSC2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009857-RA">
        <property type="protein sequence ID" value="AEPI009857-PA"/>
        <property type="gene ID" value="AEPI009857"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009857"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000157">
        <property type="entry name" value="39S ribosomal protein L2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="1">
        <location>
            <begin position="70"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009857-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="159" mass="17685" checksum="A6D7C596EB3F349F" modified="2016-09-07" version="1">MANLARLLSRLSLSPLAKDVRHTAVRPISLESLERFLNKPKPGGGKSFRRIVHYPEEYTVEPLRVTNLAGRDPETGRLIAKGIGGGIKHKYHWIKWVRDGPIEGPPQIEKVIDVIDDGCRTAKVALVAVGNEMKYILATENMKAGDLIKTSRFIPRIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSJ6</accession>
    <name>A0A182PSJ6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GD_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PSJ6"/>
    <dbReference type="STRING" id="199890.A0A182PSJ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009931-RA">
        <property type="protein sequence ID" value="AEPI009931-PA"/>
        <property type="gene ID" value="AEPI009931"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009931"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031986">
        <property type="entry name" value="GD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16030">
        <property type="entry name" value="GD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131897" evidence="1">
        <location>
            <begin position="24"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Serine protease gd N-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009931-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="278" mass="30138" checksum="ED52A6F213D50DE8" modified="2016-09-07" version="1">MAGFVTYLVLPVVLLEMCRGSFAASLSNGVPNAVSPCPTIFRYATDSIKQQIYGIVDTSEQLVDKVGTLELHLSIAGELHSKYVGSIEAIEDSAQILEQFGKGRGVTYRVNFPIQEPLPKLTKVIFNGRELCTGPADRGSFVSAVTLRHFLRSDSCKDKCDRTKLVPTALTLNLTPPAPAPVVSPSTAVAPLPVQIPKVKDGAVTTQKLTGDAPGVQHEYQRTIERKEETNNPQDNSTSVKYIREEITYRKQVIAPGGATALQADELQLPSFVSDKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PT81</accession>
    <name>A0A182PT81_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PT81"/>
    <dbReference type="STRING" id="199890.A0A182PT81"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010167-RA">
        <property type="protein sequence ID" value="AEPI010167-PA"/>
        <property type="gene ID" value="AEPI010167"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010167"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06847">
        <property type="entry name" value="HFD_SUPT7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039460">
        <property type="entry name" value="SUPT7L/Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28598">
        <property type="entry name" value="STAGA COMPLEX 65 SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28598:SF1">
        <property type="entry name" value="STAGA COMPLEX 65 SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010167-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="347" mass="39817" checksum="66AAA1B63FDCA727" modified="2016-09-07" version="1">MKRSHWGKFVDATDTRKELEANDIVLTMSKMDKFQQIKLPYTITREKRVPLKNPLVTQTVEVMKQTEMIQTLIDTYSTKSGCNYILNPCQLMPTVHFPSSNVVDLTRMEKITRPLWFVLPDETPFTRGDRRNYVKLSKPVVLQALRKAACGLLCMEGFSEINESALIMIVDGLDQYLRLFTSSLRSVRTEQNEEVGPTPTLAMVQRVCLSIGRSPVYHLHNYYKKLMNKNRDEVREFKDIYQEYDRLLQENQLSVQNMQRLGDLKEEDYMNFLDPQSHSSNGTTMDGTTMNIINFINGETVNGFKDILEGDLLESSSTQDSSDQMHNQQFYQADSSSQGGFAPSGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTM9</accession>
    <name>A0A182PTM9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PTM9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010315-RA">
        <property type="protein sequence ID" value="AEPI010315-PA"/>
        <property type="gene ID" value="AEPI010315"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010315"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010315-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="231" mass="26963" checksum="A754397AEB53C902" modified="2016-09-07" version="1">MSENTRVHETSSSEAEDELDTLAHRMILYFYHSQAIAKDAWDIHFWQKFGQINPDVELGPKELRSYFFHEIMRKPREWRGLEYEQIQYLNPLFNRIRKEVLEYRDLVEGIDYVHITDPVATLPMVTNDTLPPLFLEPSNMVSSSRATKRYITPTAEQIRSFVSAGLSELLWTEDEKTTKTPLNIEESMLRIGVLTKNSISLTDCIEPGMACYERFHQTDRTEALKADELKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTS3</accession>
    <name>A0A182PTS3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CLIP domain-containing serine protease</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTS3"/>
    <dbReference type="STRING" id="199890.A0A182PTS3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010359-RA">
        <property type="protein sequence ID" value="AEPI010359-PA"/>
        <property type="gene ID" value="AEPI010359"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010359"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131948" description="CLIP domain-containing serine protease" evidence="12">
        <location>
            <begin position="26"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="14">
        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="306"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="14">
        <location>
            <begin position="314"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010359-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="63253" checksum="86D5B8FF29A6C504" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTW5</accession>
    <name>A0A182PTW5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial glutamate carrier 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glutamate/H(+) symporter 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Solute carrier family 25 member 18</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamate(in) + H(+)(in) = L-glutamate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTW5"/>
    <dbReference type="STRING" id="199890.A0A182PTW5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010401-RA">
        <property type="protein sequence ID" value="AEPI010401-PA"/>
        <property type="gene ID" value="AEPI010401"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010401"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000026">
        <property type="entry name" value="Putative mitochondrial glutamate carrier 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF5">
        <property type="entry name" value="AT03939P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="93"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="200"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010401-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="299" mass="31945" checksum="2F30A670AC572A57" modified="2016-09-07" version="1">LLPKIINGGIAGIIGVSCVFPLDLVKTRLQNQQVGPNGEKMLDCFKKTYRAEGYFGMYRGSAVNILLITPEKAIKLAANDFFRHHLTTSNGTLPITRQMAAGGLAGLCQIVITTPMELLKIQMQDAGRVAAQAKAVGKTIPKVSATSIAMELIRTKGITGLYKGTGATMLRDVSFSIVYFPLFATLNSLGPRRDDGSNEAVFWCSFLSGCAAGSMAALAVNPFDVVKTRLQALKKVEGEMQFNGVADCIGKTLKHEGVTAFFKGGLCRMIVIAPLFGIAQMVYFLGVAEALLGVKSGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU26</accession>
    <name>A0A182PU26_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU26"/>
    <dbReference type="STRING" id="199890.A0A182PU26"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010462-RA">
        <property type="protein sequence ID" value="AEPI010462-PA"/>
        <property type="gene ID" value="AEPI010462"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010462"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11367">
        <property type="entry name" value="RNase_PH_RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="163"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010462-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="265" mass="28586" checksum="912C73EF91B96E63" modified="2016-09-07" version="1">MEIESEIVVHASGSARLRLANTDILVGVKAEIDTPHPDRPNEGKIDFFIDCSANATPEFEGRGGEQLATEISNTLAKAYESRKGFDLSGLCIMASHQCWKLYVDVLILECGGNLFDAVSLAVKGALFNTRIPRVSTAMHDGGSMDLILTDDPYDCERIDVTTAPILVTVCKIGDQCVVDPSAEEEECSVVSVAVGISSRPDGKQSITTVRTSGEGSIRFETLKKCFDTASTVGASLNTALMKALQEDETRNSKGLGRREIYGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUD9</accession>
    <name>A0A182PUD9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUD9"/>
    <dbReference type="STRING" id="199890.A0A182PUD9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010575-RA">
        <property type="protein sequence ID" value="AEPI010575-PA"/>
        <property type="gene ID" value="AEPI010575"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010575"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="63"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010575-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="452" mass="50528" checksum="F554B20AA4548C81" modified="2016-09-07" version="1">MSNCWSPKLLAIRFHALAATFNRCYHRATALHRPSGPPKLSPYDVNCILRANEHTQEFFGGSVKSYDSNQLASNSPIEDSRSEASCVYTSGLLLGIFDGHGGPACSQVISKRLMRYIAASLVPPDDLRQHLEFVSEIKELYEKSFNQFANELTNTTLAGFQMHQTLENAFLRLDQDLSREAIEMPSLRTMSVAMSGAVALVAHIDGPHLHVASVGDCSAVLGTVTDTGQWVAKKLTNEHNSDNVGEVRRLLSEHPATERDTVIRGERLLGQLAPLRAMGDFRYKWTREQLEQLVVPQFGEQVIAPYYQTPPYLSACPEITHHILTPRDKFLIIASDGLWDTMSAMQTVHLVGEHMYGKAFLQPLTLPKQDITLGEISQMLTTRKAGLQRKPLDRNAATHLIRNALGGTEYGVEHSKLSHMLSLPQDIVRLFRDDITITVVYFDSEYLRNCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUJ4</accession>
    <name>A0A182PUJ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl-CoA hydratase domain-containing protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play a role in fatty acid biosynthesis and insulin sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUJ4"/>
    <dbReference type="STRING" id="199890.A0A182PUJ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010631-RA">
        <property type="protein sequence ID" value="AEPI010631-PA"/>
        <property type="gene ID" value="AEPI010631"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010631"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052377">
        <property type="entry name" value="Mitochondrial_ECH-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602:SF1">
        <property type="entry name" value="ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010631-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="268" mass="29000" checksum="48987F5D76CB9902" modified="2016-09-07" version="1">KKIHCSAVSQKCLSTYTCQDGVGTILLDNEKTRNSLSLEMMNSIEKNIVENQHDAELRCIVLAAQGRVFSAGHNLKELTTEHGSEYHKKVFHKCSELINAIHSAPVPVIAKVDGLAAAAGCQLIASCDMAVCSDISTFSTPGASFGIFCSTPGIAVVRAVPRMKAAYMLFTGLPITANEALQAGLVSKVVPQADLNDEVSKICRAIASKSRAVITLGKTFFYKQIPLDITTAYELGEQIMVDNLATVDGREGIRSFTEKRPPKWSHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUJ9</accession>
    <name>A0A182PUJ9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUJ9"/>
    <dbReference type="STRING" id="199890.A0A182PUJ9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010636-RA">
        <property type="protein sequence ID" value="AEPI010636-PA"/>
        <property type="gene ID" value="AEPI010636"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010636"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF168">
        <property type="entry name" value="PROTEIN APTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010636-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="122" mass="13694" checksum="B01EB0EA84691162" modified="2016-09-07" version="1">MRTSFKHHQLRTMKSYFAINQNPDAKDLKQLAQKTGLSKRVLQVWFQNARAKWRRNVMRQDVGMGNPGQTLGGLPSIGAVTLHHHHHSANGSNGPNDPGSMGDLSSTQVLEEMHNMTFAELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUQ0</accession>
    <name>A0A182PUQ0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-actin binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUQ0"/>
    <dbReference type="STRING" id="199890.A0A182PUQ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010687-RA">
        <property type="protein sequence ID" value="AEPI010687-PA"/>
        <property type="gene ID" value="AEPI010687"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010687"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.330:FF:000014">
        <property type="entry name" value="Abl tyrosine kinase, isoform H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015015">
        <property type="entry name" value="F-actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08919">
        <property type="entry name" value="F_actin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00808">
        <property type="entry name" value="FABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-actin binding" evidence="2">
        <location>
            <begin position="934"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="757"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
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            <begin position="94"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
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            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
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            <end position="358"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="683"/>
        </location>
    </feature>
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        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010687-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1059" mass="112548" checksum="E4B1B8CDEA7103D3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUQ7</accession>
    <name>A0A182PUQ7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUQ7"/>
    <dbReference type="STRING" id="199890.A0A182PUQ7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010694-RA">
        <property type="protein sequence ID" value="AEPI010694-PA"/>
        <property type="gene ID" value="AEPI010694"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010694"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010694-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="234" mass="25586" checksum="EC2AD2AEC2794D4B" modified="2016-09-07" version="1">MEELTVSPSQFTTEEDDPQIHGSTSRTMAAISLGFIVIVTPWTILEIVATCTGSKCTGSRSSLEEKCSISLEYDHHLTSLPLPPGPPPATICRSANQTPRPDVECSEKYWGDILERTFSSGSVNTLHRLGSGSLPFVNRAPAPTHLPVQYRCEAHQHHLMRNASSTSIDKERHSTGSSHYKDAPSAKDASDTFGTLYAPGSDPQVCDHELHDINCAKNKAFFRGFNLHQGLPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUV9</accession>
    <name>A0A182PUV9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUV9"/>
    <dbReference type="STRING" id="199890.A0A182PUV9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010746-RA">
        <property type="protein sequence ID" value="AEPI010746-PA"/>
        <property type="gene ID" value="AEPI010746"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010746"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010746-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="138" mass="14742" checksum="D56698E51141EB9A" modified="2016-09-07" version="1">MQRHAEGCGSLWSKQTEQHGTGSSTDGRRSVLQPTLAAGSTAQPATATASTSFASGSGTVTRSSSNEWVVIPVFVDIIKLALKAREDCCVRLPNGHINMTAFDRLAAIVGAFTRHMIQVNQTLPDVGQYATLCQFMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVV5</accession>
    <name>A0A182PVV5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVV5"/>
    <dbReference type="STRING" id="199890.A0A182PVV5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011092-RA">
        <property type="protein sequence ID" value="AEPI011092-PA"/>
        <property type="gene ID" value="AEPI011092"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011092"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09771">
        <property type="entry name" value="Tmemb_18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011092-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="134" mass="15184" checksum="FCA88B2EBF8D4389" modified="2016-09-07" version="1">MSPSETSACEDLKAFERRLTEVIACLQPPTLRWRLLLGVTSLVTFVGAFYWLTDPRTSIVPLIESLLNHSIFTISTIILLILFVFGIHKLVIAPQIITSRTRNVLAEFNMSCDETGKLIVRPRPTNNSRYMDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVX6</accession>
    <name>A0A182PVX6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Adenosine kinase</fullName>
            <shortName evidence="10">AK</shortName>
            <ecNumber evidence="3 10">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="3 10"/>
    <dbReference type="AlphaFoldDB" id="A0A182PVX6"/>
    <dbReference type="STRING" id="199890.A0A182PVX6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011113-RA">
        <property type="protein sequence ID" value="AEPI011113-PA"/>
        <property type="gene ID" value="AEPI011113"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011113"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF5">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="11">
        <location>
            <begin position="54"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011113-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="363" mass="39834" checksum="674F695F2B07145D" modified="2016-09-07" version="1">DRCPRLVAFGNILLDISVELKDGKILNDFDLKPDDQREVSADKLAALVSVAVETCGNPIYNPGGSALNTCRILRALGEKNIIFCGAVGVDENGQILQQILKDCALNTCIQTLPDEMTGTCMCLISGDKRSLNANIGASLHFKKEFSKIGVCKSAAHTNIDEDMRIFYIEGYFVPEKFHICTYIYEQYCKGTANLLVTNLNASYILQEFTTEMRFLVEHADLVFGNLAEFIALAQIYSCDDVDSLARLLIKPYRKHNRNKILIATDGCRNVRLYYGAGSKFIAECYPVPVIPANLVIDTTGAGDSFVAGFLYKFMNDENPTLVDCIRYGCKVAGKVIRQVGCNLPSSVPSSPSVAACAKEGMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW46</accession>
    <name>A0A182PW46_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7775 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PW46"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011183-RA">
        <property type="protein sequence ID" value="AEPI011183-PA"/>
        <property type="gene ID" value="AEPI011183"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011183"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056677">
        <property type="entry name" value="DUF7775"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038976">
        <property type="entry name" value="Ssk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36692:SF2">
        <property type="entry name" value="GEO12064P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36692">
        <property type="entry name" value="PROTEIN SNAKESKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24985">
        <property type="entry name" value="DUF7775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7775" evidence="3">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011183-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="156" mass="17415" checksum="423A43C41A0C03C0" modified="2016-09-07" version="1">MAENSSVVPPPRVHQSALPVGMHPTAPREYRPPLSIIKFLELSLAITCTALHYYSFDDGDLVTGFLATGTFCGFIVILLTVMAGYLMKAHLHRRLSIFYSLLGCACFLTSGVFIIEAWEHAFRTRTRDLAITKGSIAVINGVIFLMDTIFTFRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWQ8</accession>
    <name>A0A182PWQ8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWQ8"/>
    <dbReference type="STRING" id="199890.A0A182PWQ8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011395-RA">
        <property type="protein sequence ID" value="AEPI011395-PA"/>
        <property type="gene ID" value="AEPI011395"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011395"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042378">
        <property type="entry name" value="IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15256">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN DGCR2/IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15256:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN DGCR2_IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011395-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20118" checksum="A88CEBE81AC612F7" modified="2016-09-07" version="1">AYGNVVSLPGECRDVNGKKVEQDAHYVPPGSDTCRLCLCDNGHPKACKAVLCSPPHDCKSFQIGSSCCEFICLDDTIGNTTDKTYDVGIRLRHRKSRAQEGREVIDDPNQRNLVNNVSYMGGSIGYLGGGTMNMDYSYVDHAVAPHYQLWKPPGAYYTRGEAPPPYEEAIAIAHAESLSSCTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX48</accession>
    <name>A0A182PX48_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX48"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011535-RA">
        <property type="protein sequence ID" value="AEPI011535-PA"/>
        <property type="gene ID" value="AEPI011535"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011535"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011535-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="122" mass="13402" checksum="98B8E325D7A7EC6E" modified="2016-09-07" version="1">SVSPNWSEAESEETISVASSCADESDSSDGETVQGRVSMQKDQGPLAEGLRIWAWETGQTLHSVTLLLQHLRMHSHPELPADARTLLKPPPEASSNERNIVPIAGGDLWYQGVKRCLQVYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYV1</accession>
    <name>A0A182PYV1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYV1"/>
    <dbReference type="STRING" id="199890.A0A182PYV1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015019-RA">
        <property type="protein sequence ID" value="AEPI015019-PA"/>
        <property type="gene ID" value="AEPI015019"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015019"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015019-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="496" mass="56684" checksum="444DC5D9657900AD" modified="2016-09-07" version="1">MVALTWVLLLCTLLLVGGTVRWFLRRRQTFWPRHGIPAARNPHPLYGNVAGLVTRHHTATVLQRLYWEFRERQLPAGGFNLFFSPVLLVVDRALIERVLVRDFAQFQDRGLYASAQMNPLSSETLFSVAGERWHRMKQQMRPAFGAHSVRTMFPTTVRIAQTLVVYIGAQSRRRDLEWTDLMARYTTDVIGSCAFGIDCRTIRDPGTEFRAMGCRAFRCSLRRMWKLRFGYTFRRMADALRLCVSEPSVETFFLELCRSTVLHRESYRLVKRDFLQQLLEMRANGQLDMRQVAGQCYSFFIAGFETSASLLSFCLYELAKNEAVQEKLRGSIGAALEETDGQLSYDMVMALEYLDQVVNETLRMYPPVDFLFRVASNDYPVDGVGTIPRGTLCVVPVHALHHDAEYYPQPEVYDPGRFAANGSKAHTRPFLPFGMGPRHCLGDTFGLMLVKVGLVAMLRSFRFSLDVDRTPETVTFKPRSLVLTASSGMYLNVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PK95</accession>
    <name>A0A240PK95_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PK95"/>
    <dbReference type="STRING" id="199890.A0A240PK95"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015327-RA">
        <property type="protein sequence ID" value="AEPI015327-PA"/>
        <property type="gene ID" value="AEPI015327"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015327"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004097">
        <property type="term" value="F:catechol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1520:FF:000001">
        <property type="entry name" value="Hemocyanin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF24">
        <property type="entry name" value="GH04080P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="10">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015327-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="695" mass="79454" checksum="4857EF7CB9F10C1B" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PKY3</accession>
    <name>A0A240PKY3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A240PKY3"/>
    <dbReference type="STRING" id="199890.A0A240PKY3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015246-RA">
        <property type="protein sequence ID" value="AEPI015246-PA"/>
        <property type="gene ID" value="AEPI015246"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015246"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16504">
        <property type="entry name" value="RING-HC_COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="57"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="551"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="637"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="734"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="739"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015246-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="801" mass="86313" checksum="A928B454DE8FA812" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PM47</accession>
    <name>A0A240PM47_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PM47"/>
    <dbReference type="STRING" id="199890.A0A240PM47"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015365-RA">
        <property type="protein sequence ID" value="AEPI015365-PA"/>
        <property type="gene ID" value="AEPI015365"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015365"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012851183" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="30"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015365-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="268" mass="28330" checksum="8A793801EA74D7A9" modified="2017-10-25" version="1">MFKCLVLCAFLAGGAMAIGGGSETLASARISGGELTDPRAVPFIVGILISGSSSHSFCAGILISPTHVLTTASCVSNRPTLTVLLGASDMTRIQQFIGVANILIHPNYSSLFNRDDLAILTMDRATPLNEYIQVANLPRWSHMGNTFNGFGTTISGWGNTGNRDNEPIPTPNLQSIRTPVISNTVCGISHNFIRDDHICTSGDNGGPCNGDDGGPVTITEAGQPIVIGMHSFHYSGLFGCDRGRSAVHVRLSSYLSWIEANSAAVIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9GVN7</accession>
    <name>A0A2C9GVN7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A2C9GVN7"/>
    <dbReference type="STRING" id="199890.A0A2C9GVN7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015420-RA">
        <property type="protein sequence ID" value="AEPI015420-PA"/>
        <property type="gene ID" value="AEPI015420"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015420"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08308">
        <property type="entry name" value="Death_Tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001863">
        <property type="entry name" value="TUBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000118">
        <property type="entry name" value="TUBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029397">
        <property type="entry name" value="Tube_Death"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF102">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14786">
        <property type="entry name" value="Death_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="419"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="257"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015420-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="699" mass="76394" checksum="98184B1E7E1B8D3A" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWI5</accession>
    <name>A0A3F2YWI5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWI5"/>
    <dbReference type="STRING" id="199890.A0A3F2YWI5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015428-RA">
        <property type="protein sequence ID" value="AEPI015428-PA"/>
        <property type="gene ID" value="AEPI015428"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015428"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000034">
        <property type="entry name" value="Protein arginine N-methyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="19">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="18">
        <location>
            <begin position="287"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="20">
        <location>
            <begin position="406"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015428-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="560" mass="63872" checksum="42180649C276A6BE" modified="2019-01-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWJ2</accession>
    <name>A0A3F2YWJ2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWJ2"/>
    <dbReference type="STRING" id="199890.A0A3F2YWJ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015441-RA">
        <property type="protein sequence ID" value="AEPI015441-PA"/>
        <property type="gene ID" value="AEPI015441"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015441"/>
    <dbReference type="Proteomes" id="UP000075885">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyt_P450_CS"/>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
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        <property type="entry name" value="Cyt_P450_sf"/>
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        <property type="entry name" value="Insect_CytP450_Detox"/>
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        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
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        <property type="entry name" value="CYTOCHROME_P450"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00004174"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015441-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="60598" checksum="9D401309AC3DE933" modified="2019-01-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWJ4</accession>
    <name>A0A3F2YWJ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="12">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Specifically phosphorylates the activated forms of G protein-coupled receptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12008"/>
            <dbReference type="Rhea" id="RHEA-COMP:11260"/>
            <dbReference type="Rhea" id="RHEA-COMP:11261"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWJ4"/>
    <dbReference type="STRING" id="199890.A0A3F2YWJ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015438-RA">
        <property type="protein sequence ID" value="AEPI015438-PA"/>
        <property type="gene ID" value="AEPI015438"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015438"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05605">
        <property type="entry name" value="STKc_GRK4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000009">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000074">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
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        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF28">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="15">
        <location>
            <begin position="59"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="243"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="509"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="615"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057847"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR600239-51"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015438-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="649" mass="73566" checksum="6F77C9F4D2C5C634" modified="2019-01-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWM8</accession>
    <name>A0A3F2YWM8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWM8"/>
    <dbReference type="STRING" id="199890.A0A3F2YWM8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015469-RA">
        <property type="protein sequence ID" value="AEPI015469-PA"/>
        <property type="gene ID" value="AEPI015469"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015469"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="6"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015469-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="545" mass="61361" checksum="55334AE98AE64E7A" modified="2019-01-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZP6</accession>
    <name>A0A182NZP6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 19">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="13">IMP dehydrogenase</shortName>
            <shortName evidence="13">IMPD</shortName>
            <shortName evidence="13">IMPDH</shortName>
            <ecNumber evidence="13 19">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13 19">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13 19">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13 18">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="13 19"/>
    <dbReference type="AlphaFoldDB" id="A0A182NZP6"/>
    <dbReference type="STRING" id="199890.A0A182NZP6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000127-RA">
        <property type="protein sequence ID" value="AEPI000127-PA"/>
        <property type="gene ID" value="AEPI000127"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000127"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 19" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 13 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 13 19" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="109"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="173"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="13 14">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13 14">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="318"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="358"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="381"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="405"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000127-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="512" mass="56046" checksum="5FABA4DF3B754DA5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0Z4</accession>
    <name>A0A182P0Z4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P0Z4"/>
    <dbReference type="STRING" id="199890.A0A182P0Z4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000576-RA">
        <property type="protein sequence ID" value="AEPI000576-PA"/>
        <property type="gene ID" value="AEPI000576"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000576"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000109">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000686">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="13"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="276"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="379"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="735"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="884"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1022"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1088"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="797"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1048"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1092"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000576-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1267" mass="141658" checksum="CCCC67B76FC633F0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1F0</accession>
    <name>A0A182P1F0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxoglutarate/malate carrier protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71587"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>maleate(in) + 2-oxoglutarate(out) = maleate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71599"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30780"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>malonate(in) + 2-oxoglutarate(out) = malonate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71591"/>
            <dbReference type="ChEBI" id="CHEBI:15792"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate(in) + 2-oxoglutarate(out) = oxaloacetate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71603"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>succinate(in) + 2-oxoglutarate(out) = succinate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71595"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1F0"/>
    <dbReference type="STRING" id="199890.A0A182P1F0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000732-RA">
        <property type="protein sequence ID" value="AEPI000732-PA"/>
        <property type="gene ID" value="AEPI000732"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000732"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000013">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="89"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="189"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000732-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="293" mass="31699" checksum="9BDD1615059F8634" modified="2016-09-07" version="1">MVGQIGATCVVQPLDLVKTRMQISGMGGAAKEYNNTFDAIGKIVRREGVLAMYKGLSAAIMRQATYTTTRLGVYTSLNDAYKQKTNKAPNLLASMAMGMTAGAIGSFVGNPSELILIRMTADGRLPVAERRNYTGFFNALFRIAREEGVLSLWRGCVPTMGRAMVVNAAQLASYSQAKAYLVSSQLLQEGIGLHFTASMFSGLITTAASLPVDIAKTRIQNMKVAPGQTPPYKSTIDVIVKVIRHEGLFALWKGFTAYYGRLGPHTVLTFIILEQLNGLYNKHMGVDGSKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1L0</accession>
    <name>A0A182P1L0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P1L0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000792-RA">
        <property type="protein sequence ID" value="AEPI000792-PA"/>
        <property type="gene ID" value="AEPI000792"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000792"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903394">
        <property type="term" value="P:protein localization to kinetochore involved in kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055403">
        <property type="entry name" value="ARM_KNTC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057303">
        <property type="entry name" value="Rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019527">
        <property type="entry name" value="RZZ-complex_KNTC1/ROD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24520">
        <property type="entry name" value="ARM_KNTC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10493">
        <property type="entry name" value="Rod_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24504">
        <property type="entry name" value="Rod_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rod N-terminal" evidence="2">
        <location>
            <begin position="167"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 first ARM-repeats" evidence="3">
        <location>
            <begin position="335"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="RZZ complex subunit KNTC1/ROD C-terminal" evidence="1">
        <location>
            <begin position="1464"/>
            <end position="1963"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000792-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2014" mass="229932" checksum="5C68F2017CB203B5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1N0</accession>
    <name>A0A182P1N0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1N0"/>
    <dbReference type="STRING" id="199890.A0A182P1N0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000812-RA">
        <property type="protein sequence ID" value="AEPI000812-PA"/>
        <property type="gene ID" value="AEPI000812"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000812"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130710" evidence="1">
        <location>
            <begin position="22"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000812-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="220" mass="22141" checksum="5B2E60B6ED3710E9" modified="2016-09-07" version="1">MNKLLASGLLVLFVAASFASGSMFGPFGPFGPGAQLPGAVGGFPGAVGGFPGAAGGFPGAVGGLPMFPGRPGVGQLPVFPPSLYPPMPFLPPAPVVPYTYGRAALAPTPMAPAPAPVANLRTVASNADVLGRLAVADLPEDLQQRAQDLQAAGEKGFDACEQMLTTSGSFWQYKRCTALQLRTVLTAAKALEQEATARTAAAAAAAPAVGEQQVVEPAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1U4</accession>
    <name>A0A182P1U4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-macroglobulin receptor-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1U4"/>
    <dbReference type="STRING" id="199890.A0A182P1U4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000878-RA">
        <property type="protein sequence ID" value="AEPI000878-PA"/>
        <property type="gene ID" value="AEPI000878"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000878"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049135">
        <property type="entry name" value="TEP1_CUB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21412">
        <property type="entry name" value="TEP1_CUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="3">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="4">
        <location>
            <begin position="761"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000878-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="860" mass="97554" checksum="F83538F94BDD0A13" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1X7</accession>
    <name>A0A182P1X7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182P1X7"/>
    <dbReference type="STRING" id="199890.A0A182P1X7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000911-RA">
        <property type="protein sequence ID" value="AEPI000911-PA"/>
        <property type="gene ID" value="AEPI000911"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000911"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF81">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="30"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="379"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000911-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="485" mass="55530" checksum="BF274FFC77AE1CF5" modified="2016-09-07" version="1">MNRKTIDTGPLVGEDKLNVAEFYRDATVLITGGTGFIGKVLVEKLLRCFEVKKIFLLIRRKENASAADRLQRMLEGPIFDTIRSTAPDAKERFAKVVAMDAAFEREDIVDDVDKTKLCNEVQIIFHVMASIRFNEVLDQAIATNVTSAQRLYALASSMAELRSIVHVSTFYANCDRNYIEERIYDDVPYGGLDRIQVFFKNLSEEEKERMTRLVLGDMPNSYVFSKKCAEAMIGREFGRLPIGIFRPPIVISSYREPEPGWVDCFHGATGLCVPVVLGKTMWYYGKPEVKPFMSPVDHTVSGMLAAACDIYRRQCTILPVEKPVPVYNFTFDKNRFAFGDMVELVGSGLPNPLDRWLSRIKCRISPWKIFPQMLLWLTTLQARIADEILAWFGKRGSNLKVVAAITTLSNAVEYFRCHMWTMDNSNVKRMLSLLSRDDAQRLDFDGDRIDWRDYHKSYAKGIAMELMRKSHRRQQQRKSSAATRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P257</accession>
    <name>A0A182P257_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182P257"/>
    <dbReference type="STRING" id="199890.A0A182P257"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000991-RA">
        <property type="protein sequence ID" value="AEPI000991-PA"/>
        <property type="gene ID" value="AEPI000991"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000991"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000556">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="21">
        <location>
            <begin position="85"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="22">
        <location>
            <begin position="223"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000991-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1014" mass="108647" checksum="5EB2D7D255567C4F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2M7</accession>
    <name>A0A182P2M7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">INO80 complex subunit F domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2M7"/>
    <dbReference type="STRING" id="199890.A0A182P2M7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001161-RA">
        <property type="protein sequence ID" value="AEPI001161-PA"/>
        <property type="gene ID" value="AEPI001161"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001161"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033555">
        <property type="entry name" value="TFPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35084">
        <property type="entry name" value="TCF3 FUSION PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35084:SF1">
        <property type="entry name" value="TCF3 FUSION PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit F" evidence="4">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001161-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="100" mass="11580" checksum="E5FE467543961BD4" modified="2016-09-07" version="1">MTSGKPVKTHSSIPIGESKPYEHAPLDTNEAYRRGVKLLHEKCKALQRSNERLVFRLHRVQKMTRSRTRDVEFLKAKLDSFGDGWRTAIDPMDIKEEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2N4</accession>
    <name>A0A182P2N4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2N4"/>
    <dbReference type="STRING" id="199890.A0A182P2N4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001168-RA">
        <property type="protein sequence ID" value="AEPI001168-PA"/>
        <property type="gene ID" value="AEPI001168"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001168"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001168-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37714" checksum="4334378FD40661F6" modified="2016-09-07" version="1">MNVDRVRLRLNYDNVCRFCLSSDDCMPLFINSIINQRLIEAVDVLLLKVDEHDGLPNCVCACCHQRMADFARFEATALEAYNMLRSILTDTAKNDESEKDNEDSSDDVNLAPQLTRTEEEAVQKKLTSVQGAESIILEIESVVKSETTCPESKARQKKACPVCGKLVSQISKHIPVHGSKTKHYACEQCDKRFANQTTLRKHLKIHRNVRNYRCEHCEASFCDRSSLRYHLAKHRGVAAFQCEFCDRGFYTSSQLRQHQNLAHRERKFRCDVCGQMFLLKHHLMEHAQLHSDGRPHECDLCGKAFKRERYLYVHRRRRHSTQEGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P315</accession>
    <name>A0A182P315_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P315"/>
    <dbReference type="STRING" id="199890.A0A182P315"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001303-RA">
        <property type="protein sequence ID" value="AEPI001303-PA"/>
        <property type="gene ID" value="AEPI001303"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001303"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000332">
        <property type="entry name" value="Ankyrin repeat family A protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001303-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="214" mass="22986" checksum="A52980F7A7FC2DE5" modified="2016-09-07" version="1">MSSSPNSEEDRKMDFNPLLLASGKRKSAFLPYKPSNTVLTNLQRGNTEANIASEICLNFHEKTGQGEITEEQVRAEQAVDVLDADQFTPLHWACYYGQLAAASILIKCGADVNKQAIDMITPILLAGAGGHNEIVRLLVDNGAVVNHMDIVGNTALMYAAAGNHPHTCNELLNAGASFTDTNEDGESAYSLAVKNNANLAQAVLENHITAMLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3B2</accession>
    <name>A0A182P3B2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal transducing adapter molecule 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3B2"/>
    <dbReference type="STRING" id="199890.A0A182P3B2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001397-RA">
        <property type="protein sequence ID" value="AEPI001397-PA"/>
        <property type="gene ID" value="AEPI001397"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001397"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21388">
        <property type="entry name" value="GAT_STAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11820">
        <property type="entry name" value="SH3_STAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03568">
        <property type="entry name" value="VHS_STAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000009">
        <property type="entry name" value="Putative signal transducing adapter molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="31"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="208"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="557"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001397-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="81944" checksum="CA8BD0385CB1C599" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3U7</accession>
    <name>A0A182P3U7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sacchrp_dh_NADP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3U7"/>
    <dbReference type="STRING" id="199890.A0A182P3U7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001583-RA">
        <property type="protein sequence ID" value="AEPI001583-PA"/>
        <property type="gene ID" value="AEPI001583"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001583"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000178">
        <property type="entry name" value="Saccharopine dehydrogenase-like oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001583-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="430" mass="48402" checksum="016EFEAC64656883" modified="2016-09-07" version="1">MDQKEERLDVIIFGASGFTGKYTIYEGIKLLEGLRWGVAGRSREKLRKTVAEIEKKADKDLSELPIITADLKDADSLKQMAERCKVLINCCGPYRFYGEPVVKACIEAGTHHVDVSGEPQYMERMQLEYHQQAQERGVYVVSACGFDSIPADLGTVFLEQQFDGVVNSVETYLQVTSKIPHDGGAVLHYGTWESAIYGLAHANELRPLRTQLYKTRLPNFQPRLRDRMVVHKASFLNGWWAVPFPGSDRSVVMRSQRHFYDAEKKRPIQMKAYVAFESIVQVLAVAFVAIVFAIMCRFKFGRQMLLKFPKLFTFGYASHEGPTEKSMENAEFTIYFRGEGWDKDEKLLEPTDQFKSPPTKKIVTKVSGTNPGYGATCVALVLSALTILRESDKMPGTGGVYPPGAAYAKTSLIEQLCKNGFKFEVIKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P554</accession>
    <name>A0A182P554_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC-2 type transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P554"/>
    <dbReference type="STRING" id="199890.A0A182P554"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002042-RA">
        <property type="protein sequence ID" value="AEPI002042-PA"/>
        <property type="gene ID" value="AEPI002042"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002042"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF29">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="862"/>
            <end position="880"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="895"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="938"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="975"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1006"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1093"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="7">
        <location>
            <begin position="861"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002042-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1125" mass="125186" checksum="8ABF2D1C84071879" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5H6</accession>
    <name>A0A182P5H6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
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        <property type="protein sequence ID" value="AEPI002166-PA"/>
        <property type="gene ID" value="AEPI002166"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002166"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048729">
        <property type="term" value="P:tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZAD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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            <end position="434"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
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            <end position="462"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="566"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="922"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="950"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="1137"/>
            <end position="1211"/>
        </location>
    </feature>
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        <location>
            <begin position="1552"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1580"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1608"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1636"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="258"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="1333"/>
            <end position="1442"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="233"/>
            <end position="246"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
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    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
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    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="71"/>
        </location>
        <ligand>
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    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="568"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002166-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1687" mass="195063" checksum="AD3FCD719F5EFDC9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P679</accession>
    <name>A0A182P679_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4794 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P679"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002427-RA">
        <property type="protein sequence ID" value="AEPI002427-PA"/>
        <property type="gene ID" value="AEPI002427"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002427"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131021" description="DUF4794 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002427-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="29571" checksum="FB817F60E0C3BE8B" modified="2016-09-07" version="1">MNHWRSRRSVAILLLVALAVVQIDSLPVTSFLDDDSDYDDSFENDDYDLVFDQRQNGTANVHLSVDGVMLALPAPEMQPSATLAGATLLDLFASQLAEAGESEDDSSEESYGTIPGSSPSAAAGAASGASTSSSSSTTASASSTTTVAPSSASPSVASDSFTYQDLPTNLPASLLGQGLSFFFNPKHGEIPFRLNAGGVETTKQSAPILITKLDKAPVVKDVQSGDSNEDSREVEEPAPQQTSKQQQGGKRKRKHKRKYKLRVANLLRPLLKRTVLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6M2</accession>
    <name>A0A182P6M2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Pre-mRNA-splicing factor CDC5/CEF1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6M2"/>
    <dbReference type="STRING" id="199890.A0A182P6M2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002570-RA">
        <property type="protein sequence ID" value="AEPI002570-PA"/>
        <property type="gene ID" value="AEPI002570"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002570"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000091">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="16">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="15">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="15">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="16">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="836"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="728"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="882"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="909"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="921"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002570-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="936" mass="105650" checksum="A729D3E8305DC0AE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P706</accession>
    <name>A0A182P706_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cullin-5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P706"/>
    <dbReference type="STRING" id="199890.A0A182P706"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002706-RA">
        <property type="protein sequence ID" value="AEPI002706-PA"/>
        <property type="gene ID" value="AEPI002706"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002706"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000142">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000009">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000014">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000004">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000050">
        <property type="entry name" value="Cullin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="450"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="117"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002706-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="821" mass="93552" checksum="A919C9C3110F66D8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P769</accession>
    <name>A0A182P769_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="AlphaFoldDB" id="A0A182P769"/>
    <dbReference type="STRING" id="199890.A0A182P769"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002771-RA">
        <property type="protein sequence ID" value="AEPI002771-PA"/>
        <property type="gene ID" value="AEPI002771"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002771"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002771-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="233" mass="26905" checksum="9DA1E6F88BD58CC8" modified="2016-09-07" version="1">MAQDKKDQTSSLVKGYLTLYNTAQFAGWTYIFVQFMQHFAVHGQSLDTLWSRVGQATFFFQMLAILEIVHAMFGIVPSSVSMTFLQVFGRCMIVAGAIEGTPTGQKSPGLPLALFCWSLTEIVRYSYYVANMLLPSVPSFLVWLRYTIFIPMYPCGFLGELLCSYWAQSYIRDTGKWSVELPNRFNFSFSFYYFMWIMAICYMPLFPQMYLHMFAQRRKVFGRGGVLKTVKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7H4</accession>
    <name>A0A182P7H4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P7H4"/>
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        <property type="protein sequence ID" value="AEPI002876-PA"/>
        <property type="gene ID" value="AEPI002876"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002876"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055444">
        <property type="entry name" value="ARM_ECM29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23702">
        <property type="entry name" value="ARM_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="ECM29 ARM-like repeats" evidence="7">
        <location>
            <begin position="661"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="8">
        <location>
            <begin position="1329"/>
            <end position="1491"/>
        </location>
    </feature>
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        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1213"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1700"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1802"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1220"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002876-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1917" mass="213230" checksum="24B2268333000B17" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7L3</accession>
    <name>A0A182P7L3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-formyltetrahydrofolate cyclo-ligase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7L3"/>
    <dbReference type="STRING" id="199890.A0A182P7L3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002916-RA">
        <property type="protein sequence ID" value="AEPI002916-PA"/>
        <property type="gene ID" value="AEPI002916"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002916"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017:SF0">
        <property type="entry name" value="METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002916-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="80701" checksum="89C75824C6FE517C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P864</accession>
    <name>A0A182P864_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">39S ribosomal protein L11, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P864"/>
    <dbReference type="STRING" id="199890.A0A182P864"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003117-RA">
        <property type="protein sequence ID" value="AEPI003117-PA"/>
        <property type="gene ID" value="AEPI003117"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003117"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000008">
        <property type="entry name" value="39S ribosomal protein L11, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000003">
        <property type="entry name" value="39S ribosomal protein L11, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="12">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="11">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003117-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="196" mass="21827" checksum="4F60BA8A6FF225B4" modified="2016-09-07" version="1">MSKAAGRLKTMKKTFDKINHTSRLRTNIPAGMAVAGPPLGPMLGQRGINIAAFCKDFNERTKDIKEGIPLPCRVAVTSDRAYELTIHSPPATFLLKQAAGIQRGAMNPGKEIAGKITRKHLYEIAKIKLQDPPNALLTLEHMCKALVGAARTCGIKIVDELDPAEYKEFLEQRRQVVEDQRKELQEKREARMLRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8L2</accession>
    <name>A0A182P8L2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8L2"/>
    <dbReference type="STRING" id="199890.A0A182P8L2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003265-RA">
        <property type="protein sequence ID" value="AEPI003265-PA"/>
        <property type="gene ID" value="AEPI003265"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003265"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="6">
        <location>
            <begin position="72"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003265-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="232" mass="25975" checksum="ED408A4B9C0E9F9D" modified="2016-09-07" version="1">MADEAFENFDEDAAPQEMDDAVKDDQVAQVYEEAPVVQTAELPEIKLFGRWSSDDIDISDISVSDYIAVKEKHAKYLPHSAGRYAAKRFRKAQCPIVERLTNSLMMKGRNNGKKLKAVRIVRHAFEIMHLLTGENPLQIVVHAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8L9</accession>
    <name>A0A182P8L9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8L9"/>
    <dbReference type="STRING" id="199890.A0A182P8L9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003272-RA">
        <property type="protein sequence ID" value="AEPI003272-PA"/>
        <property type="gene ID" value="AEPI003272"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003272"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
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            <begin position="57"/>
            <end position="79"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="180"/>
            <end position="201"/>
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            <end position="262"/>
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        <location>
            <begin position="535"/>
            <end position="554"/>
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            <begin position="122"/>
            <end position="559"/>
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        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003272-PA"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="670" mass="75629" checksum="45791BDCB72D8FC1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8P9</accession>
    <name>A0A182P8P9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AEPI003303"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131103" evidence="1">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003303-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="124" mass="12662" checksum="EE92364D2BE88FAC" modified="2016-09-07" version="1">MYKLFVFACFLAVAAAAPGLAVVPAVPVVHAAPVVHAAPVAVSHSSSHVVHHAPVVKTVAVHSAPVVAVHHAPVVKAVPVVHHAPVVHSAPLVKTVVHSAPVVHSVHPVPVVKSLVHSPVVLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P917</accession>
    <name>A0A182P917_9DIPT</name>
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        <recommendedName>
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            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182P917"/>
    <dbReference type="STRING" id="199890.A0A182P917"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003421-RA">
        <property type="protein sequence ID" value="AEPI003421-PA"/>
        <property type="gene ID" value="AEPI003421"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003421"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF12">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="364"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003421-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="508" mass="58377" checksum="9870A3DEF4D2D097" modified="2016-09-07" version="1">MKDLAKKTPVQTWYTGKTIFVTGGSGFMGKVLLEKLLYSCSDLERIYVLMRPKRGKSPQTRIDDWLKLPVFKRIREEKPKVYKKLVPIPGDVTSDKLGISPEHEQLLIENAEIVFHCAATLKLEARLKDAIEMNTIGTKRILDLCLQMKRLKALLHLSTAFCYCDKEVLTEKVHDFHHNPYDLMRTVEWMDEKALDMITPNLLTPHPNTYTYSKRLAEMMVRDAYSKLRVCIVRPSIVCPANAEPVEGWVDSLNGPVGIMVAGGKGIIRSMLCNGEYNAEVIPVDIAINGLITIAYTLGQMEEMPKEIPVYNITCRETKRTTWKEVLDLGKATAYEYPFEAGVWYPDGDITMNKTYHNIIVLLFHWLPAYFIDFLMFCFGQKRFMCRIQNMVSEGLSLLQFFTTRQWDFKSHQYQAIAKDLSPEDNVIFTMDVDAIDTKDYLRRIILGGRQYCMKEPLSTLPKARIQLKCLWVLDKVAKAFVLYGLAWLFLTLTGLKAPVYEMLGWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9H6</accession>
    <name>A0A182P9H6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9H6"/>
    <dbReference type="STRING" id="199890.A0A182P9H6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003581-RA">
        <property type="protein sequence ID" value="AEPI003581-PA"/>
        <property type="gene ID" value="AEPI003581"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003581"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF65">
        <property type="entry name" value="TCTEX1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003581-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="177" mass="20609" checksum="D97782A2A163A776" modified="2016-09-07" version="1">MTTWGGLKIGSKPGQKGDKQAPMRFSDTLTAALANRKNKYKDVSKDLNGLINREELEDEIFVANYSIRKIKSMIARVVKQQFIVRNEDGDLLKWVYNPEKNLEMSQSIAKAVKDRLRNLNLPRYRVVCFCSIVEKQQQGVHYKMKYILDPYMDNYVQYVHDGAIFWIITTAFLVHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9N1</accession>
    <name>A0A182P9N1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitoferrin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9N1"/>
    <dbReference type="STRING" id="199890.A0A182P9N1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003636-RA">
        <property type="protein sequence ID" value="AEPI003636-PA"/>
        <property type="gene ID" value="AEPI003636"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003636"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000127">
        <property type="entry name" value="MC family mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000054">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF20">
        <property type="entry name" value="MITOFERRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="105"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="196"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="342"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003636-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="414" mass="43926" checksum="C00E3D4A6131C928" modified="2016-09-07" version="1">MNSDEYEQLPTSSVPAIMTAGAIAGVMEHCVMYPLDSVKTRMQSLTHMKAHDTIMSTLRDMIRNEGLMRPFRGVLAVVAGAGPAHALYFGAYECSKEMIATVSDRDHLNYMLSATAATLVHDAVSNPADVVKQRLQMYNSPYRSIMHCATQVYRTEGLRAFYRSYSTQLVMNIPYSAIQFPTYEFFQKLLNKDNKYNPPVHMVAGGAAGAAASALTTPLDVCKTLLNTQEDGAGKTRGLVEAAKKIYNTAGVMGFFKGMQARVLYQMPATAICWSTYEFFKYILSRVKKPTAGGAAMPGDGGEATIADLRYMLPVSAAVSAEAASPAGCGGVVNSASLLIRSPERSEGGPGGATGAGSGDSKSGSGAGGTSAGLIPRGGPELPAMSGAGIYGAMSYNTMHSNDTNHLTDVRRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9R9</accession>
    <name>A0A182P9R9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P9R9"/>
    <dbReference type="STRING" id="199890.A0A182P9R9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003673-RA">
        <property type="protein sequence ID" value="AEPI003673-PA"/>
        <property type="gene ID" value="AEPI003673"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003673"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003673-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="71945" checksum="4C2E2CB542057A4D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA69</accession>
    <name>A0A182PA69_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PA69"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003823-RA">
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        <property type="gene ID" value="AEPI003823"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003823"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003823-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="451" mass="49169" checksum="E863B1831406E130" modified="2016-09-07" version="1">MSKSPASVVSSDETHSASDESLVISAATSHTSLRSIGVTKSVRKTSKDEASAASGPMVKERPPWRPASLTAVVVPPPPKPDIKARLLEASKRMRRINAVVQTDPVHTKLMKEVSTDEQTDLIPMVDEAILTDGNLVIRDVGNLILTHSVAQMTDGVETCNSGTQTAIPRSGISFRKFLEPISAHDRVTSPVATPFKLPEDDHLDEEATKLEAEQQIKTIFPTIELEPLVESFGSDAAGEPCSSQSGSDSIKETNTPDLISATVEGDPSPHRTAITLLDTPTFAAWQNLDFSDEESESYVPRELPRRPIGEGDRPWAEFKDLVVGSRVANMRLSPVPPRKPRAPNQKTVTWSDRQHRAVSKLINEASALVDMFDHVSMLLGPDIALHKLPPQQEFHLPPAKWEPLLTKSCDLLEEKLAQVRHLSLSDFESAAGEPEIPLTSPMLSDVGPEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAC6</accession>
    <name>A0A182PAC6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAC6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003880-RA">
        <property type="protein sequence ID" value="AEPI003880-PA"/>
        <property type="gene ID" value="AEPI003880"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003880"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003880-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="272" mass="31012" checksum="4A622EA02CB2FEA8" modified="2016-09-07" version="1">MNQKIDDTGNEQSGPFRRGDRANRHVQQDSVAHETRPEFWAQLIAYIDCRHVVLLDSFGFFANRPVLAKRLFARLTAAGVRVSVQRQLRAVSKLPPVTHRLAIIVPIVMKPSKALAVELDTFIAQIKLEPNFVEFYLWMFVFQSAHKKNVWRALHQLPIRADSHVYCGIVGNSAAVPFVKRIHLERKMMPTDRFVRRMQMLPPHHPEAANRTSAILTLPGPSVTGRVAVWQLYRLQTHRKTIDVAVELLGRYSGSTRKNLTGSLLDRMGLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAF6</accession>
    <name>A0A182PAF6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAF6"/>
    <dbReference type="STRING" id="199890.A0A182PAF6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003910-RA">
        <property type="protein sequence ID" value="AEPI003910-PA"/>
        <property type="gene ID" value="AEPI003910"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003910"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000008">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
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    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
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            <end position="368"/>
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            <end position="426"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="414"/>
        </location>
    </feature>
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        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003910-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="782" mass="88116" checksum="134020F01D18B684" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAW3</accession>
    <name>A0A182PAW3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="13">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:46858"/>
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            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
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        <property type="gene ID" value="AEPI004068"/>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0030036">
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:morphogenesis of an epithelium"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:salivary gland morphogenesis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TyrKc"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="183"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="251"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="367"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="44"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362096"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004068-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="627" mass="70480" checksum="0FADF1F79453A8A5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB27</accession>
    <name>A0A182PB27_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PB27"/>
    <dbReference type="STRING" id="199890.A0A182PB27"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004132-RA">
        <property type="protein sequence ID" value="AEPI004132-PA"/>
        <property type="gene ID" value="AEPI004132"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004132"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040709">
        <property type="entry name" value="Importin_rep_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040520">
        <property type="entry name" value="Importin_rep_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18773">
        <property type="entry name" value="Importin_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18806">
        <property type="entry name" value="Importin_rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004132-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="996" mass="113138" checksum="F715C5EB8E9EFE72" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB50</accession>
    <name>A0A182PB50_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Intraflagellar transport 43</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFT43 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PB50"/>
    <dbReference type="STRING" id="199890.A0A182PB50"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004155-RA">
        <property type="protein sequence ID" value="AEPI004155-PA"/>
        <property type="gene ID" value="AEPI004155"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004155"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029302">
        <property type="entry name" value="IFT43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33724">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33724:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15305">
        <property type="entry name" value="IFT43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004155-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20038" checksum="14600762ACF718C0" modified="2016-09-07" version="1">MQEKSTPPSTNAAGTPAKVKTDNSWLEDSSSSGRSLSTLTSATTGHGKNARSKFSNILEMERFSNSNIVPMDDTSTTVDYNPIDDIPVLPDADDIHESLLYNESPNLPTVTTYKNLSSDIFANGKASALGNLDEIDISILTECLESEEDIEEPDEPWTWDQLFTQLSVKISTETKSPVVEFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBE7</accession>
    <name>A0A182PBE7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBE7"/>
    <dbReference type="STRING" id="199890.A0A182PBE7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004252-RA">
        <property type="protein sequence ID" value="AEPI004252-PA"/>
        <property type="gene ID" value="AEPI004252"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004252"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="2">
        <location>
            <begin position="83"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004252-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="304" mass="35986" checksum="2489DF46305E0FF7" modified="2016-09-07" version="1">MQLKKRPRRRREDENEKIARGYKTVMAYATAEEYDLHRLLKALRDQNLYEPKQFLSSDDIDTEPDVLHVTAKYKVGDECRDLYFFREGTVVLWNCTDLESSNILRFLRPFEQDPYDEGTVLEESESMLYNQDGIARLKHNSFYVSNSEEADLEKYTFSNAMSLSVKLGIWEASLERYIDSMAYVTEDLKKGNKIKITRPEMLRRTGELFALRHVINLSSDLLDTPDFYWDREQLETLYNHTCAYFSITRRTRVMNEKLNHCVELADLISSNLNDDHHVRLEWMIIILIMVEVGFEVLHYVDRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBF4</accession>
    <name>A0A182PBF4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBF4"/>
    <dbReference type="STRING" id="199890.A0A182PBF4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004259-RA">
        <property type="protein sequence ID" value="AEPI004259-PA"/>
        <property type="gene ID" value="AEPI004259"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004259"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF9">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004259-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="344" mass="38058" checksum="44E49C9D7AF27645" modified="2016-09-07" version="1">MANCTFFSLLLTMQRTEERSVQLAVRVHKTLELADDKFYVITCGKTGFARDDSGAVALKFLDSTGRRVRETVYNREYTIKAEVTNPNGTYGIRVKNCFAFNKKNMSVALIDDRGCPLKNDTMTRFRTSADGTSATAQIMSMFKFSEGSEVHFQCDVVQCNGRCPELDEAICTGDANAYVKSARSLGQVDDGMLLAATTVFVIDPAFAPVISPICDDTGIRPHWLLWLTIALGVLFLIMLLMNIFLCTAMSCSCAQTEIIEKEPSIIEEYDPYRSWHGSQYGSRYSLHGGREGGHNKGYTSGGSTIHSNRSLPIDSDHYAIVHSRPGSRHSGLHGHRPRGPPSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBP1</accession>
    <name>A0A182PBP1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBP1"/>
    <dbReference type="STRING" id="199890.A0A182PBP1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004346-RA">
        <property type="protein sequence ID" value="AEPI004346-PA"/>
        <property type="gene ID" value="AEPI004346"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004346"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14766">
        <property type="entry name" value="CeGLB25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF5">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="6">
        <location>
            <begin position="38"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004346-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="217" mass="24171" checksum="3966A2BC2096EB8D" modified="2016-09-07" version="1">MGCELTKLAGSSNGSNSKSNNMPSLDACGPPPVDSRLPLTAKQKYTMVASWKGISRAMETTGITMFIKLFEEHADLLNMFTKFKELKTKEQQATSEELQEHANKVMNTLDEGIRGLDDLDTFFEFIHQVGASHRRIPGFKQEYFWRIEEPFLSAVSTTLGDRYTQNVEGIYKLTIKFIIETLVAGYEASANNNVDNTTTTSSSTPATKLPDEPNRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC46</accession>
    <name>A0A182PC46_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC46"/>
    <dbReference type="STRING" id="199890.A0A182PC46"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004501-RA">
        <property type="protein sequence ID" value="AEPI004501-PA"/>
        <property type="gene ID" value="AEPI004501"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004501"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF646">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="8"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="580"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="807"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="513"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="787"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="820"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004501-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="831" mass="90162" checksum="2E60D387C58FAEB4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCK0</accession>
    <name>A0A182PCK0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCK0"/>
    <dbReference type="STRING" id="199890.A0A182PCK0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004655-RA">
        <property type="protein sequence ID" value="AEPI004655-PA"/>
        <property type="gene ID" value="AEPI004655"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004655"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF13">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM" evidence="3">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004655-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="456" mass="49493" checksum="3F0FC8105706CE5D" modified="2016-09-07" version="1">MIRSSSPHPLKSFSSTRDAVDKPDKPEKHHKKKEGGMSWEQKKFAQHFAQVPDDEVVLDYFSCALVGDILLQGYLYITQNYFAFYSNVFGYVTKLLIPTVSVLDISREKTAYMFPNAVGVKTRDDRHVFGSFLSREAAFYLMCSVWERATTPQSGDSLGAIHHTRLAPLHAEGSEGSLDEDSSCYDGNESSFHGKDDMPDLLDSGDSHEKQQNATEAGGGTNQSSDDSTILLKQKKLKKELLLKSPAIVKSPAILKVAVAAGALEGLKSEKAIPILPGSLLGDGGVGGPLGGGVGAGRVVYGDGAGRSRLSLVKQKLRHILPSDFGIIHIGLILAVLLALFSGFLAYKIYALQARLAAPPLRLGDDTDFYLDVLRWQKRLHSKSKEEAQIVLNSNLEQIIKVRKSLETLSLLIQDSPTDGSGAEDAALLSAMIADDSVLEDSGGSLNQQYFHEDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCU9</accession>
    <name>A0A182PCU9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCU9"/>
    <dbReference type="STRING" id="199890.A0A182PCU9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004754-RA">
        <property type="protein sequence ID" value="AEPI004754-PA"/>
        <property type="gene ID" value="AEPI004754"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004754"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052253">
        <property type="entry name" value="CR1/CR2-DNA-binding_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006:SF9">
        <property type="entry name" value="GLUCOSE TRANSPORTER 4 ENHANCER FACTOR, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006">
        <property type="entry name" value="PAPILLOMAVIRUS REGULATORY FACTOR PRF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="305"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004754-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="368" mass="39792" checksum="96B69CD0CF0164DC" modified="2016-09-07" version="1">MASGQVLMSRSCVARRTQVFKPKIRHVSQRIFKCTWKGCHVVYNTCTEITQHVRNAHLGPRKPNEYSDEEDFFFTETEDESDESAPNPPSPPTLSHRDMARPPHEDPEYQRQIVGTYRQGLLSQSQAIQQQAAHQQQHQVQQQQQQQQIASIKPPLPAGLTVAALSSTNGTTSSSNGAGSNGSSSNSNGSSGSSNGAVNPHSSVSPLIHHNYTWSQVSPTSPQKHVRLSPRPSAAYPYPSPNYQHHYQAQAAQQQQQHHQQQLGHIQLSPGGAASANNGTAAYHQLLAGAAGAASGAITLGTYSSSPGSSGGGSSVGSAGSGQHRSPVSPNRRTRGENKKCRKVYGMDHKDQWCTQCKWKKACSRFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDK9</accession>
    <name>A0A182PDK9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDK9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005014-RA">
        <property type="protein sequence ID" value="AEPI005014-PA"/>
        <property type="gene ID" value="AEPI005014"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005014"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010629">
        <property type="entry name" value="Ins_allergen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21163">
        <property type="entry name" value="PROTEIN G12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21163:SF1">
        <property type="entry name" value="PROTEIN G12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06757">
        <property type="entry name" value="Ins_allergen_rp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005014-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="235" mass="27701" checksum="5213BCDC9D74455B" modified="2016-09-07" version="1">MVCVAGERTNRRTVWGPLAALLLLLVELDQIFGYHIRHIQEEPSHQLQQDLMDFIDLVPFEDVQRLMQYYYHHDLEVESAFDYVSTEDYTQIRLDIVNLGEVRSFRRYLDSIGFSVEKVWTELNKRFDADDIFAEPDESVRMLNLTTRGLNGLVDDILALLPQDEIILLFFDKLETSNDFSFFFEQIGSGEFENVLNTLQSSQQLRILLWRLQRHGFDIPGWIQLVQKYFSFSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDU9</accession>
    <name>A0A182PDU9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDU9"/>
    <dbReference type="STRING" id="199890.A0A182PDU9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005104-RA">
        <property type="protein sequence ID" value="AEPI005104-PA"/>
        <property type="gene ID" value="AEPI005104"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005104"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780:SF18">
        <property type="entry name" value="LD43650P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="149"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005104-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37781" checksum="9EC019C6DDB8FD6E" modified="2016-09-07" version="1">MYANNQPIIIGTPLREKREEEDVDVDSSLRFGFRLVCSTALYPLEYAKTLIQLGYEPIAPRPGRTLFGARRLMLPNIFQYAAYIKSVDGFTGCFRGLSARLLGNVLGSYYGERLAIALLSKPPKTVLQPDFFEFGVEMWEKYDFNEPRPVFKADIVSKAVTQVCGIVISHPFHVISIRMMAQFIGREHLYDGLFGSIKEIWVQEGIRGFFSGLIPRLWMEACCMALTTAISYLFKKYSGANKTICGHVDTISHFTVTSMLYPYHVVSTCMAVQGCRLKAGNPPFMDHFISWRHCHAHLTLQNQHKRGSSFFFRTVARAPGKINDAFAPYPEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE80</accession>
    <name>A0A182PE80_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PE80"/>
    <dbReference type="STRING" id="199890.A0A182PE80"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005235-RA">
        <property type="protein sequence ID" value="AEPI005235-PA"/>
        <property type="gene ID" value="AEPI005235"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005235"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF144">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="174"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005235-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="455" mass="50042" checksum="C149206FF0C4A12D" modified="2016-09-07" version="1">MDYIKELDIRLDKEHYYAGEVLSGRVIMHTTENFKLKSIRLLLRGKAHVEWKVFVSGDKRTVKDDQVYIDERAVIWGERAGEGLDVTVPVLKRGQHQFPFRFNIPETNLPCSFESRACYIRYFVKVTIDIPYASPPQGIKYFTIIGPHIDCMDEQYLKPVSGQDKKVKCCLCCAKGPVTLSCSLDRTAFCCGETLKLKSIIDNQGEEAVKLKVRLLQYCEFFVERGVLGVTKEVQHLVLEYKGETVVPNERQDTCANLRIPTVPTTMMGVCRLAQIYYTLVACLEFDKSGDDLQINFPITIGTVPFRIPNSNLQPHIGYDVAIDHVEGGTYIGPEFLLGEVYDGCNVSDNEHRDLAPLYRPVYLTVVRSSQQISAKAVERNNRRQSATAVLGSGTSSGGGGGGSGGAGGGGNPTPSSSSMDPYGSGGAASSSSSAGVNGGRCSMEGKNDLQRYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEH7</accession>
    <name>A0A182PEH7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEH7"/>
    <dbReference type="STRING" id="199890.A0A182PEH7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005332-RA">
        <property type="protein sequence ID" value="AEPI005332-PA"/>
        <property type="gene ID" value="AEPI005332"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005332"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000038">
        <property type="entry name" value="Ebony protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000088">
        <property type="entry name" value="Ebony protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005332-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="887" mass="99476" checksum="57C1DE61A70CD9A2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEI4</accession>
    <name>A0A182PEI4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEI4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005339-RA">
        <property type="protein sequence ID" value="AEPI005339-PA"/>
        <property type="gene ID" value="AEPI005339"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005339"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF106">
        <property type="entry name" value="FI01104P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005339-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="357" mass="39381" checksum="0C1F9090C66C0E9D" modified="2016-09-07" version="1">MAALYAAQQSEVMVDVTICCENRKLRAHKLVLAMGSPFFRSVFDECATPHPVVALRSVNYEELELLIKFLYVGEVYVQHKRVRSLVNAALFLQLNEFSSLLPFIKPDGSLDENLPGMVNTVNLGLAEINIPPTVVQPSGRSETGKSFRVVIEKKPIDKMEQPQQPTAINCSESDEDTDDDQDESVADQTMAMPVLNQPRELTTLRRGTTYVLPPNTTIIINDKGSRNVRNNEPSANLTVTSSDGTGSVSRTTQPIVPSLLQQAIVSMVPRTVQNVFVSLFTVPVDPHRCQLASTTVNTLTGSQDQRMINDDCSMFSDGHPSPGPTVMSVQEVDDYFHDDNCLSFDMQGEETRAGAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEL3</accession>
    <name>A0A182PEL3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein on Y chromosome</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEL3"/>
    <dbReference type="STRING" id="199890.A0A182PEL3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005368-RA">
        <property type="protein sequence ID" value="AEPI005368-PA"/>
        <property type="gene ID" value="AEPI005368"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005368"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF6">
        <property type="entry name" value="EF-HAND CALCIUM BINDING DOMAIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="387"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="476"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="785"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005368-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="992" mass="111732" checksum="DC15073CCD490700" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEN0</accession>
    <name>A0A182PEN0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEN0"/>
    <dbReference type="STRING" id="199890.A0A182PEN0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005385-RA">
        <property type="protein sequence ID" value="AEPI005385-PA"/>
        <property type="gene ID" value="AEPI005385"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005385"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131202" evidence="2">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005385-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="128" mass="14385" checksum="29AB2D00AB3F3C08" modified="2016-09-07" version="1">CLTASFLFLFWALPVAVLIRSTQCCELDQTQHGCRIDNGQCTCAFGCKSEFRYATRKECQDALKGRSSDICNRQPCMNGGACTQVTTMPQYKCRCEGTGYWGNRCHRMCPKPDQLPLGTKFPHECVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEN4</accession>
    <name>A0A182PEN4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEN4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005389-RA">
        <property type="protein sequence ID" value="AEPI005389-PA"/>
        <property type="gene ID" value="AEPI005389"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005389"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005389-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="224" mass="23967" checksum="CB744662B3BACDD9" modified="2016-09-07" version="1">MKWKNKEPKQSISSVTSMSFLSDENLTFHRFSDGTISFTSERKKSMQNVLDAGGGGAPMMTLASAPNAKQPVPPSTAIGTMNGGQSHTIERTRKHSYTQATTGSSPIWTTNASFNNYTTNTITNSNRRHAGRPRSVAPVGDVTDGEGGGSTTTAGIPTLSDLRYLSSPSTNPNNSSVIQNGSTVKLISTKVSANTVAASDDQSNKQFGPARDWTDQFQRFLKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF80</accession>
    <name>A0A182PF80_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PF80"/>
    <dbReference type="STRING" id="199890.A0A182PF80"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005585-RA">
        <property type="protein sequence ID" value="AEPI005585-PA"/>
        <property type="gene ID" value="AEPI005585"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005585"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16227">
        <property type="entry name" value="EFh_CREC_RCN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000104">
        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000424">
        <property type="entry name" value="GM18042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000463">
        <property type="entry name" value="intraflagellar transport protein 80 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000033">
        <property type="entry name" value="Outer segment 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056456">
        <property type="entry name" value="Beta-prop_IFT80_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098:SF0">
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
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        <source>
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        </source>
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            <dbReference type="PROSITE" id="PS50222"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005585-PA"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1090" mass="123284" checksum="7F1CA7169881382D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFM3</accession>
    <name>A0A182PFM3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KA1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AEPI005730"/>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7084"/>
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        <property type="entry name" value="KA1_dom"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596:SF72">
        <property type="entry name" value="ZINC FINGER PROTEIN MSN2-RELATED"/>
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        <property type="entry name" value="KA1"/>
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    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005730-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1384" mass="143714" checksum="00890DC841295B71" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PG98</accession>
    <name>A0A182PG98_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PG98"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005957-RA">
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        <property type="gene ID" value="AEPI005957"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005957"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005957-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="570" mass="61011" checksum="C3DF03494144202A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGE7</accession>
    <name>A0A182PGE7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">malate synthase</fullName>
            <ecNumber evidence="1">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="1"/>
    <dbReference type="STRING" id="199890.A0A182PGE7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006006-RA">
        <property type="protein sequence ID" value="AEPI006006-PA"/>
        <property type="gene ID" value="AEPI006006"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006006"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022542">
        <property type="entry name" value="FOCAD/RST1_DUF3730"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF2">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12530">
        <property type="entry name" value="DUF3730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="DUF3730" evidence="8">
        <location>
            <begin position="468"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase N-terminal" evidence="9">
        <location>
            <begin position="1200"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="7">
        <location>
            <begin position="1340"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="10">
        <location>
            <begin position="1594"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="1343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="1627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601465-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006006-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1730" mass="197721" checksum="65BAC37312A89A5C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGL7</accession>
    <name>A0A182PGL7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium/solute symporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGL7"/>
    <dbReference type="STRING" id="199890.A0A182PGL7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006076-RA">
        <property type="protein sequence ID" value="AEPI006076-PA"/>
        <property type="gene ID" value="AEPI006076"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006076"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF2">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006076-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="67220" checksum="D6DFB9CD355D3B11" modified="2023-06-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHY6</accession>
    <name>A0A182PHY6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHY6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006547-RA">
        <property type="protein sequence ID" value="AEPI006547-PA"/>
        <property type="gene ID" value="AEPI006547"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006547"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006547-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="202" mass="21548" checksum="B840B68E62930B56" modified="2016-09-07" version="1">MMKMMKMYLLLYIYCRCGLYAFFYVGEKHSALLLPGAYTSEKHIELVEPQISTNGLTIRPLQQGMLGSTANGRLMGPGVGSSTSSSSSSSSSSTSSSLALAAAAAALQQQPSHTPHPQHQLGHHPFPGHLPAHHHLSLQPQHPALAAAHHHHHPHPHPHHHHRSIWPSLGAAATTGRTAFELQTATNGEGDANGKYTTGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHZ4</accession>
    <name>A0A182PHZ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Grh/CP2 DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHZ4"/>
    <dbReference type="STRING" id="199890.A0A182PHZ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006555-RA">
        <property type="protein sequence ID" value="AEPI006555-PA"/>
        <property type="gene ID" value="AEPI006555"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006555"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF21">
        <property type="entry name" value="GEMINI, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="3">
        <location>
            <begin position="277"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006555-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="864" mass="92658" checksum="4F6A987EE04C511E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIZ3</accession>
    <name>A0A182PIZ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIZ3"/>
    <dbReference type="STRING" id="199890.A0A182PIZ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006906-RA">
        <property type="protein sequence ID" value="AEPI006906-PA"/>
        <property type="gene ID" value="AEPI006906"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006906"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001234">
        <property type="entry name" value="AGAP013454-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001065">
        <property type="entry name" value="Reticulon/nogo receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051432">
        <property type="entry name" value="KCNMA1_auxiliary"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473:SF24">
        <property type="entry name" value="CONNECTIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473">
        <property type="entry name" value="GH08155P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006906-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45222" checksum="7ED62C6DA0EF259E" modified="2016-09-07" version="1">MTLHHYVMCNTGALREIPLKAIPVTVEQLSLTKNYFPIIKSDAFGGLRALRKLSLDGNNITTIKPFAFRGLPRLRELSIQHTPLATVASFAFAGLQNVTQIQLSHNKILRIEGYAFAGAVNIRQIHLADNPTVTIETNAFSSLSNVDRLILPSGIRAIEPDAFYGLETVGYLKLSFMDLASLVPYTFRGLTHVKLLSLQESDLGIIRAGAFEGLVHVELLNILNNKIDAIQELNITAANRIRVLRIQGNHLLETPDSGSIVLEGIETLHVNSNYFPCGCHIHTLLDSPLANGSYTSHGGAPAGDFLSKNYCISPLEVNGLPMSSIDLYSIGRCMEQVTRESLDAVNSATPAVWRGQSWHWWQQWSSERSRQPPEKTLISAVSSAVRFLAASPLMLSMLFVGCCQIFSIKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJF8</accession>
    <name>A0A182PJF8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxisomal multifunctional enzyme type 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJF8"/>
    <dbReference type="STRING" id="199890.A0A182PJF8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007072-RA">
        <property type="protein sequence ID" value="AEPI007072-PA"/>
        <property type="gene ID" value="AEPI007072"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007072"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007072-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="724" mass="77829" checksum="60A0EFA3BEBC5FD6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJN1</accession>
    <name>A0A182PJN1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJN1"/>
    <dbReference type="STRING" id="199890.A0A182PJN1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007145-RA">
        <property type="protein sequence ID" value="AEPI007145-PA"/>
        <property type="gene ID" value="AEPI007145"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007145"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131359" description="Secreted protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007145-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="25184" checksum="6113E479047A4B62" modified="2016-09-07" version="1">MSYQLPVKCTFIVTVLAVTLVSGRPATSDSIYFPTDDHVEHSLPVFEQSAASNTGSQTVVGKDGSVQQQNFGSSMSSNVASDLSSGQLSATNTQQSSLQSGDKFQSANSAQGQSAAFDREKQALANANTNTNVVRDGANVREQTAGGAASSLKTTQGSQASQAQTNSESFKEPGKEGNRTTGSAQSQNIGMDGTGSASNANTGSEKIVLADGTVITKSFGSSSSFQVSGNTKASSMAQTFSQSFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK08</accession>
    <name>A0A182PK08_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PK08"/>
    <dbReference type="STRING" id="199890.A0A182PK08"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007274-RA">
        <property type="protein sequence ID" value="AEPI007274-PA"/>
        <property type="gene ID" value="AEPI007274"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007274"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007274-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="93" mass="9342" checksum="44C0FE55B41A342D" modified="2016-09-07" version="1">MNNYQAAAAAAAQGFGPPASPHTTTTRTAAGFPNANSPGPTIDMYSSSAADSVGYVQATSPQPSGFPAIAVSRAPLNYSPGQLIPAAFTNGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKA2</accession>
    <name>A0A182PKA2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-binding cassette sub-family F member 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKA2"/>
    <dbReference type="STRING" id="199890.A0A182PKA2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007368-RA">
        <property type="protein sequence ID" value="AEPI007368-PA"/>
        <property type="gene ID" value="AEPI007368"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007368"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000688">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058770">
        <property type="entry name" value="PWI_ABCF3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26051">
        <property type="entry name" value="PWI_ABCF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="201"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="514"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007368-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="730" mass="80680" checksum="3B50C38110217D2D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKJ5</accession>
    <name>A0A182PKJ5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein neuralized</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in neurogenesis. Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKJ5"/>
    <dbReference type="STRING" id="199890.A0A182PKJ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007462-RA">
        <property type="protein sequence ID" value="AEPI007462-PA"/>
        <property type="gene ID" value="AEPI007462"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007462"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16647">
        <property type="entry name" value="mRING-HC-C3HC5_NEU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000441">
        <property type="entry name" value="Neuralized, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000005">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase NEURL1B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF6">
        <property type="entry name" value="PROTEIN NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NHR" evidence="15">
        <location>
            <begin position="67"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="15">
        <location>
            <begin position="307"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="671"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="613"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007462-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="724" mass="78806" checksum="FAB8CEB2C6F50E33" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLA1</accession>
    <name>A0A182PLA1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182PLA1"/>
    <dbReference type="STRING" id="199890.A0A182PLA1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007718-RA">
        <property type="protein sequence ID" value="AEPI007718-PA"/>
        <property type="gene ID" value="AEPI007718"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007718"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000092">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="5"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007718-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="540" mass="60236" checksum="BFB995A6B737E8E5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLP3</accession>
    <name>A0A182PLP3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLP3"/>
    <dbReference type="STRING" id="199890.A0A182PLP3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007863-RA">
        <property type="protein sequence ID" value="AEPI007863-PA"/>
        <property type="gene ID" value="AEPI007863"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007863"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007863-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="376" mass="44186" checksum="134EDC54B17784FE" modified="2016-09-07" version="1">MEPLEQWFVLSGYVRFHQWLGCQPYRLDNGSVSPFAVHTLVQFLAVAANLTLIIYRRRCILYHCEAIGMVVDFIKLLTVGLAISVTYVELFRNVNNVCSCWRMLYKAHRTLQRQGMVDRHSITRAIRLYWWFVVGTMVYFAGNEWYLYDCAQEKQTKRYYVYFFGLQYLLNIKLQQIIYPAIMLDLYLRMTRAALEHHVELLQCAEKLNSARYVEFLAGKINTLKLLHNDLYQASVEINEAYGRTYLVIYCKNYIHILSNSYWTVFWMLNKQPNHAARIVCRLISRTVLLAVTFYINTRAMNTATYLRHRLHSVGIGLQIKCRPLFAMVEAFQQQASMERIQLSAGYCFDLNFKPIFTQAVNQLDEIDCSAYDTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLX0</accession>
    <name>A0A182PLX0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 222</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLX0"/>
    <dbReference type="STRING" id="199890.A0A182PLX0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007942-RA">
        <property type="protein sequence ID" value="AEPI007942-PA"/>
        <property type="gene ID" value="AEPI007942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007942"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008496">
        <property type="entry name" value="TMEM222/RTE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05608">
        <property type="entry name" value="RTE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007942-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21332" checksum="D311CC507E65CA6D" modified="2016-09-07" version="1">MSLHSDASEDLSRSSTDMGLLPPINFADDKYPYCIVWTPIPVLTWFFPFIGHMGIAMSNGVIRDFAGPYFVSEDNMGFGRPTRYLRLHPANAFGGSQNWDESVIKASATYGARMHNLFCDNCHSHVGMALALMRYKEYSNWNMVVLAFWMFFRGKYIGLRGVIKTWLPFLIIFTICALVAVYSKWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM23</accession>
    <name>A0A182PM23_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PM23"/>
    <dbReference type="STRING" id="199890.A0A182PM23"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007995-RA">
        <property type="protein sequence ID" value="AEPI007995-PA"/>
        <property type="gene ID" value="AEPI007995"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007995"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131507" evidence="4">
        <location>
            <begin position="25"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007995-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="500" mass="54264" checksum="A3D10153F2810CF7" modified="2016-09-07" version="1">MQSRRSLTVMKLTWGLMVTLGTLAGLPASCNAVAAESPEPASLLRPRDVNPHPYQHAYEGIAIFDRNLITNSEKFTQNLLNQGPVQFPRLRDGSSVNALPYPYETLALKERQEKMIRFSGADSQTVKPAYQALAKHAARVLGKSYAVEDIDSLNEAATDVKKNYVFSYAVKDTASGDDFSHTQQQQQDGAVKGSYKVQLPDGRMQVVKYIADNNGYRADVTYENEPAGVVQEAPSAGPAVATAPASPVAYQTYYAKTPVQQPQQQYLTQIRPARLYYATAPNPTQIPAPFYPTQLRPSDVKIHSYNTAPHAGAVIASTTTQATPVAGAYLATFPAAGNLAYIATSPVNGALRTVQLQSGSGGGAAGTIAVPVTAIPLAAYRDINVPPPPPVQPLGVAFASAGRRTTVYADPARVSPQAAGTLQQVIYQQQQQQQQQQQQHSAQIQQSLDYGYVQIPVDNRVYKRNTDHSTEVLVGSQASKKEAQKQRNQTKRHQQEQKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM65</accession>
    <name>A0A182PM65_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex I-49kD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase 49 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PM65"/>
    <dbReference type="STRING" id="199890.A0A182PM65"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008038-RA">
        <property type="protein sequence ID" value="AEPI008038-PA"/>
        <property type="gene ID" value="AEPI008038"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008038"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="8">
        <location>
            <begin position="199"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008038-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="469" mass="52776" checksum="61860D9EC2C200A9" modified="2016-09-07" version="1">MAFSVLSTVAKRTAANVYVTGGGLVKNVAALCNAQPARSAGKWFPDEQFIDQFKGPVMYPDEVTSRWKLPPWNSKIAPVEKTVRNLSLNFGPQHPAAHGVLRLVLELDGETVMRADPHIGLLHRGTEKLIEYKTYTQALPYFDRLDYVSMMCNEQCYSLAVEKLLNIDVPLRAKYIRVLFAEITRILNHIMAVGTHALDVGALTPFFWLFEEREKMMEFYERVSGARMHAAYIRPGGVSQDLPLGLLDDIYEFASKFGERLDEVEDVLTTNRIWVQRTVDIGIVSAEDALNYGFSGVMLRGSGIKWDLRKSQPYDAYDRVEFDVPIGTKGDCYDRYLCRVEEMRQSLRIIDQCLNQMPAGEIKTDDAKLTPPSRGEMKHSMEALIHHFKLFTQGYQVPPGATYTAVEAPKGEFGLYLVSDGSSRPYRCKIKAPGFAHLAALDKIGRHHMLADVVAIIGTLDVVFGEIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMZ1</accession>
    <name>A0A182PMZ1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BEN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PMZ1"/>
    <dbReference type="STRING" id="199890.A0A182PMZ1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008315-RA">
        <property type="protein sequence ID" value="AEPI008315-PA"/>
        <property type="gene ID" value="AEPI008315"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008315"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BEN" evidence="5">
        <location>
            <begin position="75"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008315-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="410" mass="46018" checksum="9C0F6AD08088A39A" modified="2016-09-07" version="1">MIPKISGTPGTTSTITSKQTVIPAVPLQPPSVKPIAPPSESSIKQVPTIVPEPETKKSENDTSKIIEKKVPLHAGSSVYIATKDLLSIYTSKPAVYTGRLIQLMFGLETLKISCLDSKEKVGTNLVPLNPTVLNAVITHVVDVFQQQKQHITHVYNDLSQRKGSLIFSLTNNKDVMFSETSNGARQLHYQNHVYHRNIKSGNTEYWRCSKAIRLKCKATIVTKGDTMRVNGIDHNHIPMGRLMYGLAIFLAVGPEKQLIWLRGKLYQKTIGRAYRSVWTCIEYGCPGEILLLELKGGQIQITSAHNYDCTSDYLKNRPVNQMYLNESELTRLEQTLANEAARFIAGVRGSRKLKVGDYSFTKNKECLDKTYWSCARAGMHRCKARVVTYTHKNGELTYILRNATHNHAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN05</accession>
    <name>A0A182PN05_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">ADP-ribosylation factor-like protein 2-binding protein</fullName>
            <shortName evidence="12">ARF-like 2-binding protein</shortName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role as an effector of the ADP-ribosylation factor-like protein 2, ARL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
            <location evidence="1 12">Cytoskeleton</location>
            <location evidence="1 12">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 12">Cytoplasm</location>
            <location evidence="3 12">Cytoskeleton</location>
            <location evidence="3 12">Microtubule organizing center</location>
            <location evidence="3 12">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the ARL2BP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN05"/>
    <dbReference type="STRING" id="199890.A0A182PN05"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008329-RA">
        <property type="protein sequence ID" value="AEPI008329-PA"/>
        <property type="gene ID" value="AEPI008329"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008329"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051457">
        <property type="term" value="P:maintenance of protein location in nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1520.10">
        <property type="entry name" value="ADP-ribosylation factor-like 2-binding protein, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038849">
        <property type="entry name" value="ARL2BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023379">
        <property type="entry name" value="BART_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042541">
        <property type="entry name" value="BART_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15487">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15487:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11527">
        <property type="entry name" value="ARL2_Bind_BART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7 12" id="KW-0969">Cilium</keyword>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BART" evidence="13">
        <location>
            <begin position="39"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008329-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="168" mass="20026" checksum="08E0196ED208054A" modified="2016-09-07" version="1">MTTTVVFFSKRVSFTIYDARTKMNFEENIIKRQNSSEYFDTVIGHIEDIVIGEEFQRMVNQFMECYYYEFEPGEENKIVYTEIYQKYTNMIEAYIVEHLNRKMSCFDMDLFAMELENKKTQLNGEIFELLYTLTDFLAFKDMVLDYKAFKEGVYDDLSKGISVTGLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN78</accession>
    <name>A0A182PN78_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN78"/>
    <dbReference type="STRING" id="199890.A0A182PN78"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008403-RA">
        <property type="protein sequence ID" value="AEPI008403-PA"/>
        <property type="gene ID" value="AEPI008403"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008403"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="222"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="503"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="559"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008403-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="601" mass="69114" checksum="3A39AAEA94672B22" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNL7</accession>
    <name>A0A182PNL7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNL7"/>
    <dbReference type="STRING" id="199890.A0A182PNL7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008544-RA">
        <property type="protein sequence ID" value="AEPI008544-PA"/>
        <property type="gene ID" value="AEPI008544"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008544"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008544-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="186" mass="19905" checksum="D968DD1F139B8956" modified="2016-09-07" version="1">MSTTLSSVSGVYPDDSEQEHGLLPDLNGVDLVMSLSPKAPNHHHHHHHHHHLTSLQHLQNLQHNSALHSHSTPFSVTDILSPIEEYRKLELTANPPSPYSGGSSVNSPSALGPNTTTGSTTTGSSSMANPYAMGPLYHSPGVQSYCAPTDNLSLAGHYTDMRNSAAAGWYGSTASDPRFASKFKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP41</accession>
    <name>A0A182PP41_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PP41"/>
    <dbReference type="STRING" id="199890.A0A182PP41"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008720-RA">
        <property type="protein sequence ID" value="AEPI008720-PA"/>
        <property type="gene ID" value="AEPI008720"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008720"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008720-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="84" mass="9545" checksum="8AF5BC47D811F3DF" modified="2016-09-07" version="1">MVPIGRWMIVYQRYLPPEPTTCCMSGCQNCVWIQYAADLTKILDDGGEKAREIVLEKISDPSLKMFLKLELQNMPPPSKSNDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP42</accession>
    <name>A0A182PP42_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Complex I-B14.7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase subunit B14.7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA11 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP42"/>
    <dbReference type="STRING" id="199890.A0A182PP42"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008721-RA">
        <property type="protein sequence ID" value="AEPI008721-PA"/>
        <property type="gene ID" value="AEPI008721"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008721"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008721-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="166" mass="18142" checksum="7ACC98E3488CD1C3" modified="2016-09-07" version="1">MSLKANYYDKPEGDDLFGKMIATNKYALAGGLGWSTIEVMMVSKPKGYLPTIARYVYFTGPFVGMASAFTVGAYAANKLRGRDDGWNYVAGAFAAGGVYGAWKRNVVSGLVAGLIFSVAGALKKQSVDEGWEFFPEVKHHAVSSINPNRYDFTLTQERERGWTTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPE0</accession>
    <name>A0A182PPE0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPE0"/>
    <dbReference type="STRING" id="199890.A0A182PPE0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008819-RA">
        <property type="protein sequence ID" value="AEPI008819-PA"/>
        <property type="gene ID" value="AEPI008819"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008819"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000035">
        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000022">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="524"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="623"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008819-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="673" mass="74736" checksum="2B66F9BDFFF4BBC8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ95</accession>
    <name>A0A182PQ95_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQ95"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009125-RA">
        <property type="protein sequence ID" value="AEPI009125-PA"/>
        <property type="gene ID" value="AEPI009125"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009125"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009125-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="75" mass="8187" checksum="A1C09FC9D6052656" modified="2016-09-07" version="1">MASTELSSISFEMTVDSVIHTGRSLRCVVVSSVSLSPIVMSTRVSSTTNPLDRLNTLDLPQEIVQRLQLLVELGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQM5</accession>
    <name>A0A182PQM5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GH16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQM5"/>
    <dbReference type="STRING" id="199890.A0A182PQM5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009256-RA">
        <property type="protein sequence ID" value="AEPI009256-PA"/>
        <property type="gene ID" value="AEPI009256"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009256"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08024">
        <property type="entry name" value="GH16_CCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000217">
        <property type="entry name" value="Gram-negative bacteria-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="36"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009256-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="414" mass="46740" checksum="2442CD44C5330150" modified="2016-09-07" version="1">MRSFFDRRTIPLLVIIVGLSAALIAVCIDAYAGDSDDVERPTVPEGEAPLECDRPSVTTASGKLVKRSAFCPGDLIFEDNFDRLDLERWEHEVTLGGGGNWEFQYYLNSRRNSYVKDGIFFIRPTLLADETGEEFLSSGNLNIHGGTPYDYCTNPAFYGCDRTGSPTNYLNPIKSARVRTVNSFNFRYGKVEIRAKIPTGDWLWPALWLMPKINQYGTWPSSGEIDLMESRGNLDYSVNGEQLGVEHIGTTLHFGPRWNLNGYEMATAVKHSPSGQGFNKGFHRYQLEWTPEFMRFSIDDEQVMQVEGNFWELGQFEQREPGVPNPWVSGGKMAPFDQEFYIIMNLAVGGTNGFFPDVPPAVNGNGKKPWTNDSPTALRDFWLGRGDWLPTWKLGENESAEASFQVDYVRVWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQP9</accession>
    <name>A0A182PQP9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium-activated potassium channel BK alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQP9"/>
    <dbReference type="STRING" id="199890.A0A182PQP9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009280-RA">
        <property type="protein sequence ID" value="AEPI009280-PA"/>
        <property type="gene ID" value="AEPI009280"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009280"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009280-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11250" checksum="14772814663765F1" modified="2016-09-07" version="1">MFGMSVVSVSTNSPAFPSTFAISRLCFTKLKLLLLAIEIKGGEEGNDSKISINPRGAKILANTQGFFIAQSADEVKRAWFYCKACHDDIKDETLIKKCKCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQX6</accession>
    <name>A0A182PQX6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transaldolase</fullName>
            <ecNumber evidence="3 8">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 8"/>
    <dbReference type="AlphaFoldDB" id="A0A182PQX6"/>
    <dbReference type="STRING" id="199890.A0A182PQX6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009357-RA">
        <property type="protein sequence ID" value="AEPI009357-PA"/>
        <property type="gene ID" value="AEPI009357"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009357"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009357-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="333" mass="36882" checksum="618E55518380BC91" modified="2016-09-07" version="1">MSSAEPQTKKTKMASSLEQLKQLTTIVADTGDFEAMKTYKPTDATTNPSLILSAAGMEQYQHLIDKAIKHGQKAGTTLDEKVSEAADMLFVLFGCEILKLVPGRVSTEIDARLSFNKEASIAKALKLIALYEEMGVKRDRVLIKLASTWEGIQAASVLEKEHNIHCNLTLLFSFAQAVACAEAGVTLISPFVGRILDWYVANTDQKTFEPEQDPGVISVTKIYNYYKKFGYKTVVMGASFRNVGEIMALAGCDLLTISPKLLGDLEKSTEPVKRYLDAEKAKTVALEKIQMDEATFRWMLNEDQMSTDKLSDGIRKFAGDGRKLETMLRGLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR59</accession>
    <name>A0A182PR59_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PR59"/>
    <dbReference type="STRING" id="199890.A0A182PR59"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009441-RA">
        <property type="protein sequence ID" value="AEPI009441-PA"/>
        <property type="gene ID" value="AEPI009441"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009441"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009441-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="413" mass="47493" checksum="59D2B2FA6F3BD5FB" modified="2016-09-07" version="1">MRCLNKNPRHVYDVVRPLLAVSKWFGQTAFSIVGEPPYVQVKVTRVEFAALFTNFVANMCCVFINVTNSQLSRLTGSMVINLGLSFLFPMGSIFMILLAIDNCLRRNVTCTILTELFKVDRSLQRKGHRLDHRRQYVVLGRILSVLIILIAFGTIFSIGMSFFSGFALRNHVINAFSYALTGVQFMIINFHFVAAARLITFRLEAIKRCLKKHSEASSWWIEQKPRWGRRVEPIDVIIELARDFAALVHIVKRINRIYSNQIIALIAGVGMFSIFVIYASSFSYYVGSTKESRLTAILLTAWVFYVIMVWLIFFAAKSVDNACEEVVSLVHEILNHTLDSSTYDKLLRFSQQILFRRPKLQCMFYVYNWQTLFRHCALLKLLQMFGTVVTYLVILLQFDKLSEDSSKGNFLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRB3</accession>
    <name>A0A182PRB3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRB3"/>
    <dbReference type="STRING" id="199890.A0A182PRB3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009497-RA">
        <property type="protein sequence ID" value="AEPI009497-PA"/>
        <property type="gene ID" value="AEPI009497"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009497"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040034">
        <property type="term" value="P:regulation of development, heterochronic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000411">
        <property type="entry name" value="Ecdysone-induced protein 74EF isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF191">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="8">
        <location>
            <begin position="195"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009497-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="291" mass="31237" checksum="E030DE621CB11170" modified="2016-09-07" version="1">MLRWHLIFHPYFLSDNYHYLHSMNSPNGYPSAAAAAAAAAANHFASGGATNGTASNGSAAGALGRGTGAGSAGQLPGNGSMGQHGHLGSHHAANAAHHHGHLGQQHLGHHPHAGSGHVGGGANSAAAAAAALMANGIVNGLGHHGQHGPHNVSSSCPDDLSYMLELGFQPRKLKKPKKPKLEMGVKRKSREGSTTYLWEFLLKLLQDREYCPRFIKWTNRDKGVFKLVDSKAVSKLWGMHKNKPDMNYETMGRALRYYYQRGILAKVDGQRLVYQFVDVPKDIVEIDCTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRQ5</accession>
    <name>A0A182PRQ5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A182PRQ5"/>
    <dbReference type="STRING" id="199890.A0A182PRQ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009640-RA">
        <property type="protein sequence ID" value="AEPI009640-PA"/>
        <property type="gene ID" value="AEPI009640"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009640"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="14">
        <location>
            <begin position="175"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009640-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="522" mass="58288" checksum="2A2D6786BE980386" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSC3</accession>
    <name>A0A182PSC3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182PSC3"/>
    <dbReference type="STRING" id="199890.A0A182PSC3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009858-RA">
        <property type="protein sequence ID" value="AEPI009858-PA"/>
        <property type="gene ID" value="AEPI009858"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009858"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009858-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="182" mass="20619" checksum="639C308B443DBDAA" modified="2016-09-07" version="1">MANGTFYYFAYGSNLLAKRIHIQNPTAVRKGFGYLKDYSLDFFHYAARWRGAPATIVEQEGKQVWGAIWEIDNSNLADLDRQEGVHNSVYKPLKLPVALPTGESLDCRVYQLVRNPCCLAPDAEDRPYERQPSKTYMNIIINGAKETGLPDDYISLLKRIKHNGNSGDPQLSLELEKPIDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSE5</accession>
    <name>A0A182PSE5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSE5"/>
    <dbReference type="STRING" id="199890.A0A182PSE5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009880-RA">
        <property type="protein sequence ID" value="AEPI009880-PA"/>
        <property type="gene ID" value="AEPI009880"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009880"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001579">
        <property type="entry name" value="Crooked legs, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF93">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 14-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="384"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="835"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="883"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="668"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009880-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="926" mass="102200" checksum="87EB9142304B919E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSK0</accession>
    <name>A0A182PSK0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="5">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PSK0"/>
    <dbReference type="STRING" id="199890.A0A182PSK0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009935-RA">
        <property type="protein sequence ID" value="AEPI009935-PA"/>
        <property type="gene ID" value="AEPI009935"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009935"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="67"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009935-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="288" mass="32990" checksum="EEDE2C31AC5E2B24" modified="2016-09-07" version="1">MLFSWLRSVGRPGLLSLSCSNVATANAAKLQEQALEEKCILVNDQDQYTGSASKRDCHRVDPKGNIRLHRAFSVFLFNSAGDMLLQRRSVEKVHDMVGTHPYTDGWSDDRAPLSPTAVSHSSVGVRLPSGGEYPANPITFPDCYTNACCSHPLYDIEGEREELNALGIRRAAQRRLNYELGIPMAQARPENFHYITRIHYADRGDGTWGEHEIDYILFLQKDVDLKPNDSEVSEVRYIKRAGLDDTITKLDAPLTPWFRLILQHRLQLWWDNLHNLKQYENHKEIERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSQ3</accession>
    <name>A0A182PSQ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA polymerase epsilon subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit POLE and the accessory subunits POLE2, POLE3 and POLE4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSQ3"/>
    <dbReference type="STRING" id="199890.A0A182PSQ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009989-RA">
        <property type="protein sequence ID" value="AEPI009989-PA"/>
        <property type="gene ID" value="AEPI009989"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009989"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000053">
        <property type="entry name" value="DNA polymerase epsilon subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024639">
        <property type="entry name" value="DNA_pol_e_bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12213">
        <property type="entry name" value="Dpoe2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000799">
        <property type="entry name" value="DNA_pol_eps_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase epsilon subunit B N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="9">
        <location>
            <begin position="284"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009989-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="521" mass="58883" checksum="A24A64C0A30483E4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PT19</accession>
    <name>A0A182PT19_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Soluble NSF attachment protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PT19"/>
    <dbReference type="STRING" id="199890.A0A182PT19"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010105-RA">
        <property type="protein sequence ID" value="AEPI010105-PA"/>
        <property type="gene ID" value="AEPI010105"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010105"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000028">
        <property type="entry name" value="beta-soluble NSF attachment protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="132"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010105-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34503" checksum="59C870486D04BBBF" modified="2016-09-07" version="1">MADNEQKAMQLIAEAEKKLNSSKSFFGSLFGGGSNKVEEAVECYQRAANMFKMAKKWSQAGSAFCEAANLHAKAGSRHDAATNYVDASNCYKKVNQLCLLMHVAKTDPNEAVNCLLKAIDIYTDMGRFTMAAKHHQSIAEMYENEANDLQRAVQHYEQAADYFKGEESTSSANKCMLKVALYAAQLEDYEKAIQIYEQVAGSCLDSSLLKYSAKEYFFRAALCHLSVDLLNAQHAMEKYAQQYPAFQDSREYKLVKTLCEHLEEQNVDGFTEAVKEYDSISRLDQWYTTILLRIKKQANDNPDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU07</accession>
    <name>A0A182PU07_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DDB1- and CUL4-associated factor 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">WD repeat-containing protein 68</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">WD repeat-containing protein An11 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat DCAF7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU07"/>
    <dbReference type="STRING" id="199890.A0A182PU07"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010443-RA">
        <property type="protein sequence ID" value="AEPI010443-PA"/>
        <property type="gene ID" value="AEPI010443"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010443"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000049">
        <property type="entry name" value="DDB1-and CUL4-associated factor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010443-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="433" mass="48742" checksum="B21C92B900433FDF" modified="2016-09-07" version="1">MDNLRRIIHLSRDQVDEEDRRDTPDSSVVFTCTASSELTRTTKSKTAVTAQPSSSFTGFVSQRNDNCRWQQQQQEQAVHDRLRPAPLGSMAGTTGKRKEIYKYLAPWPLYSMNWSVRPDKRFRLALGSFVEEYNNKVQIISLDEDTSEFSAKSTFDHPYPTTKIMWIPDSKGVYPDLLATSGDYLRLWRAGEPDTRLECVLNNNKNSDFCAPLTSFDWNEVDLNLVGTSSIDTTCTIWGLETSQPLGRVNLVSGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYEDPAHTPLLRLAWNKQDPNYLATVAMDSCEVIILDVRVPCTPVARLSNHRACVNGIAWAPHSSCHICTAGDDHQALIWDIQQMPRPIEDPILAYTAAEGEVNQIQWGATQPDWIAICYKTACEILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU36</accession>
    <name>A0A182PU36_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="199890.A0A182PU36"/>
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        <property type="protein sequence ID" value="AEPI010472-PA"/>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="7"/>
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        <property type="entry name" value="Znf_AD"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
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    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="9">
        <location>
            <begin position="42"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
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            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
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            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="762"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="504"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="801"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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            <end position="536"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="537"/>
            <end position="546"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010472-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="883" mass="98869" checksum="8A7F9CB73A0963AC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUA5</accession>
    <name>A0A182PUA5_9DIPT</name>
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        <recommendedName>
            <fullName evidence="4 8">Beta-glucuronidase</fullName>
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        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
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        <text evidence="1 8">Plays an important role in the degradation of dermatan and keratan sulfates.</text>
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        <reaction evidence="8">
            <text>a beta-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
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    </comment>
    <comment type="activity regulation">
        <text evidence="8">Inhibited by L-aspartic acid.</text>
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    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
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        <text evidence="2 8">Belongs to the glycosyl hydrolase 2 family.</text>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
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        <property type="entry name" value="GH"/>
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        <property type="entry name" value="Glyco_hydro_2"/>
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        <property type="entry name" value="Glyco_hydro_2_AS"/>
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        <property type="entry name" value="Glyco_hydro_2_cat"/>
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        <property type="entry name" value="Glyco_hydro_2_CS"/>
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        <property type="entry name" value="Glyco_hydro_2_N"/>
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        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
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        <property type="entry name" value="PRK10150.1"/>
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    </dbReference>
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        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066:SF67">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="11">
        <location>
            <begin position="38"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="9">
        <location>
            <begin position="219"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="10">
        <location>
            <begin position="340"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010541-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="690" mass="78802" checksum="D93ED9277A44903B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUP0</accession>
    <name>A0A182PUP0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM154 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUP0"/>
    <dbReference type="STRING" id="199890.A0A182PUP0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010677-RA">
        <property type="protein sequence ID" value="AEPI010677-PA"/>
        <property type="gene ID" value="AEPI010677"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010677"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033336">
        <property type="entry name" value="SAXO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516:SF16">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="456"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="927"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010677-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="950" mass="103584" checksum="A71082858C1EA5AB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVA2</accession>
    <name>A0A182PVA2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PVA2"/>
    <dbReference type="STRING" id="199890.A0A182PVA2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010889-RA">
        <property type="protein sequence ID" value="AEPI010889-PA"/>
        <property type="gene ID" value="AEPI010889"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010889"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000060">
        <property type="entry name" value="Probable beta-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008132011" description="beta-mannosidase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="12">
        <location>
            <begin position="70"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010889-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="950" mass="109277" checksum="D27E9E30631B4E70" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW19</accession>
    <name>A0A182PW19_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PW19"/>
    <dbReference type="STRING" id="199890.A0A182PW19"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011156-RA">
        <property type="protein sequence ID" value="AEPI011156-PA"/>
        <property type="gene ID" value="AEPI011156"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011156"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011156-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="252" mass="28120" checksum="8ED2206E751AE8E9" modified="2016-09-07" version="1">MSSRTGTRSQGQVDVEHHPAAQKIYPTFFRNIPPLGHSRPYYQSTEAAIEQQRFNKLRNSLPASPVPLADVASPLLGSGDFSIIKGGTFYYDTDVPGKGFTDDFYGLGYNGNNGHGRPQLAYLVQKPQKEEQFSNFRDFADINISNDPAYSHHAPLYVGIRDSENPFKSSSSMMPTPEPKTNTAGLAKREPDNILDELQSLEEASKADAKRRLRIIVKKETYLERKKRPKYGKNGNSAPMQSEGEDYMVAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWT0</accession>
    <name>A0A182PWT0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWT0"/>
    <dbReference type="STRING" id="199890.A0A182PWT0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011417-RA">
        <property type="protein sequence ID" value="AEPI011417-PA"/>
        <property type="gene ID" value="AEPI011417"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011417"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011417-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="144" mass="16331" checksum="3F6E9258A4927124" modified="2016-09-07" version="1">MVEALLEKIRKTPTVKTDKPETFLEFSAAVRNASDYLRVAELEEHLSNPTLIEELVNRLPGHMKKDWAIACTRQHHPLLHQSDENEDVFPCNHSVHIDKKGECLFRIMPVTLYRGDNQIDTCAFIDEGSSLTLMETSLAKELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWZ3</accession>
    <name>A0A182PWZ3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWZ3"/>
    <dbReference type="STRING" id="199890.A0A182PWZ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011480-RA">
        <property type="protein sequence ID" value="AEPI011480-PA"/>
        <property type="gene ID" value="AEPI011480"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011480"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22753">
        <property type="entry name" value="OTU_ALG13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049769">
        <property type="entry name" value="OTU_OTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF115">
        <property type="entry name" value="PROTEIN OVARIAN TUMOR LOCUS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="1">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011480-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="330" mass="38991" checksum="BD4DF95FC2A97373" modified="2016-09-07" version="1">MDTIKSRGFAHGCREMPDMCDRFLENLGYYRKRTAFDASSLFRVVSEHVYDIQIYHEKVRADCVDYMRQHKARFAKRITWSFESYLSKMSRSRTHGTLLELRALALQHRANVLMFEPLAEAKWFVHYHSHEKLWRIYVGHDNHFDSIFRIEYMTDVAECQAIVYNLLYKDVMRLPDVEYAVERMLHDPDDKTIKYETDSEGNQLALTENGQKLMLCKPGSGTECILVNPQLCRFHNGDNFDMTQRFFHVHGSEEGYRMYVGQSRGTKKPNPLLHDEVLSCVRQLVNLNIPPFPYKVAKTLDRNIYRNIEFDVWSEERKNKWAARVLEGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX15</accession>
    <name>A0A182PX15_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX15"/>
    <dbReference type="STRING" id="199890.A0A182PX15"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011502-RA">
        <property type="protein sequence ID" value="AEPI011502-PA"/>
        <property type="gene ID" value="AEPI011502"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011502"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011502-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="166" mass="18457" checksum="6F20E9187B334DDB" modified="2016-09-07" version="1">MNAALLHIPKGMIKWPLFIANYEHSTAICGYSDDENLLRLQRALKGAALEAVGPLLYLPSGLQEAIATLKLRFGRPEVIVEGLIEKVRRMPVPRADRLETLAEFGFAVRNMCATIRAAGLPEYTCNVVLLKELVAKLPSVACIEWARHRRQLSSITLTEFGDGWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX52</accession>
    <name>A0A182PX52_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX52"/>
    <dbReference type="STRING" id="199890.A0A182PX52"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011539-RA">
        <property type="protein sequence ID" value="AEPI011539-PA"/>
        <property type="gene ID" value="AEPI011539"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011539"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011539-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13310" checksum="B4098079BB97EE67" modified="2016-09-07" version="1">MHKVRYVIPHSCVIKPDSTTTKLRVVFDASARSIKVLQAVGPVIQPDLIHIWLEFRTHTVVATADIIKMYGQESLTRGCSASYGVITHKNPLKCIGSVPSHMAKLHHLILHAGHSTNPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYL9</accession>
    <name>A0A182PYL9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PYL9"/>
    <dbReference type="STRING" id="199890.A0A182PYL9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014415-RA">
        <property type="protein sequence ID" value="AEPI014415-PA"/>
        <property type="gene ID" value="AEPI014415"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014415"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21433">
        <property type="entry name" value="SARAH_Sav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000035">
        <property type="entry name" value="Salvador homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="5">
        <location>
            <begin position="599"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014415-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="71035" checksum="53A659D923B5CAA9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ93</accession>
    <name>A0A182PZ93_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZ93"/>
    <dbReference type="STRING" id="199890.A0A182PZ93"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015158-RA">
        <property type="protein sequence ID" value="AEPI015158-PA"/>
        <property type="gene ID" value="AEPI015158"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015158"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF103">
        <property type="entry name" value="CYTOCHROME P450 6BS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015158-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="502" mass="58151" checksum="71470B7F12C29299" modified="2016-09-07" version="1">MYLQVVAVVLIVVVACVGWIKRRYQFWKERSVAFIEPRFPYGNFGTLGKVEHIAPITQRHYDHFKRLNVPYGGVFMLTSPLLYIFDTKLIKTLLVKDFHYFPNRGVYFNERDDPLSAHMFAIEGQKWRTLRAKLSPTFTSGRIKMTLPLILEVCERFCDHLHDSLQSSSEVEVHDLLSRYTIDVIGACAFGIECNSFREPDNEFRRYGKIAFDKLRHSPLVVYLMKAFRKHANALGMKQLHDDVSGFFMRVVKDTIEYREREQIVRNDFMDLLLKLKNTGRLEADGEEIGRLTFEEIAAQAFIFFTAGYDTSSTAMSYTLYELALNPEVQQKARACVKQTLEKHGGKLSYEAVADMSYLEHCINETLRKHPPVAILERNADKDYRLPDSGLLLRRGQKIMIPIFAMHHDPEHFPEPEQYRPERFAPEEAARRDPYCYLPFGEGPRVCIGMRFGSIQAKLGLASLLNRFRFSTCERTQIPVQYSRTNFILGPANGVWLRAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PPR0</accession>
    <name>A0A240PPR0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PPR0"/>
    <dbReference type="STRING" id="199890.A0A240PPR0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015299-RA">
        <property type="protein sequence ID" value="AEPI015299-PA"/>
        <property type="gene ID" value="AEPI015299"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015299"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:hydroxypyruvate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF119">
        <property type="entry name" value="FI03731P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="41"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="136"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015299-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="347" mass="37365" checksum="17EFE7D641982955" modified="2017-10-25" version="1">MRTGAVRLAARAFSKMLDPLLQQHNFGAHRPKLAVTCADIPTRYIDLLKQNCDVTVCQGTTRTDILRSIAGAEGVLWLTADRLDGEALDAAGRQLRVVSTMTSGMDYVDADEFARRGIALGHTPKVVNDPVADIAIGLMLAAARRFHEGRLKIANGEWEMRPQWMLGQDVPGSTVGIVGFGGIGQTILKRLKGFDIGRCLYTGRRRKPEGDQAGAIFVDLTTLLRESDFVFIACPLTSETANMFNAETLATMKPSCVLINVARGGIVDQPALVEALRKGTIFAAGLDVMTPEPLDTNDPLLLLPNCVVVPHLGTATQQSLLDMFAITANNVLSVLAGGQLVAPFQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PPS8</accession>
    <name>A0A240PPS8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A240PPS8"/>
    <dbReference type="STRING" id="199890.A0A240PPS8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015329-RA">
        <property type="protein sequence ID" value="AEPI015329-PA"/>
        <property type="gene ID" value="AEPI015329"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015329"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046969">
        <property type="term" value="F:histone H3K9 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01410">
        <property type="entry name" value="SIRT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF12">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015329-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="359" mass="39902" checksum="DA94C616A84D995F" modified="2017-10-25" version="1">MSCNYAEGLSKYDNKGILGVAEIFDAPELVEEKCEQLTKMMLASKHTVVHTGAGISTSAGIPDFRGPKGVWTLEEKGEKPAVNIAFDDAVPTRTHMALRSLVASGHVQYIVSQNIDGLHLRSGLSREHLSELHGNMFLEVCIKCRRQYVRNSPAPTVGKKVTGNICPATGTGRTCRGGKLIDNILDWEHDLPENDLQMAFMHSAMADLNICLGTTLQIVPSGDLPLKNLKHGGHLVICNLQPTKHDKKADLKISTFVDTVLEKVTKRLGVEIAEYSTAEDPTKRNSYIVQWNIDGMTVKTLEKRYDKTMKEKAKFKKLNSISSTELDRDEMKRNNKKLKREQLFNGEIEGGANATKRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZN4</accession>
    <name>A0A182NZN4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZN4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000115-RA">
        <property type="protein sequence ID" value="AEPI000115-PA"/>
        <property type="gene ID" value="AEPI000115"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000115"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000115-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="54" mass="6403" checksum="3A384CAB047F2559" modified="2016-09-07" version="1">MERRKRRNEGTVEPYSPATNWTSSRRPSKKRTIRMCTPGKCFPSKRISQRTGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZW0</accession>
    <name>A0A182NZW0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZW0"/>
    <dbReference type="STRING" id="199890.A0A182NZW0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000191-RA">
        <property type="protein sequence ID" value="AEPI000191-PA"/>
        <property type="gene ID" value="AEPI000191"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000191"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000191-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="308" mass="35043" checksum="9DA2BD6966B9D198" modified="2016-09-07" version="1">MDYNISRLCRVCLEEGVFTSIFSTELVPMAPANMLVMCANIKVSRDDGLPSTICNNCMYRLGVAFHLKQQCENSDMRLRQYMNGGTAMSYSYTLDKETMTDDSWLLSGMEHKGDDQKSAEKKTNSKKRYRVRPEERKKRGPKPMPKIPQTCYQCHKSFKCAAQLQMHLSRNRDMMAHKRKMHLAECEAECYKCHECDKVFATLNNLNVHMRVHAQEVNVSVADPVVDLMPPHQQQQHHQQSHQQQQLLAHHQQVPVPIALAPHGLAPPGSLGVGLGMLPYPSSHVPAHPPAQVAYHSQMHPSQRLHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P019</accession>
    <name>A0A182P019_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P019"/>
    <dbReference type="STRING" id="199890.A0A182P019"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000251-RA">
        <property type="protein sequence ID" value="AEPI000251-PA"/>
        <property type="gene ID" value="AEPI000251"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI000251"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 3"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR46786:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zf-met"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
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    </dbReference>
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        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="U1-type" evidence="3">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="U1-type" evidence="3">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="U1-type" evidence="3">
        <location>
            <begin position="604"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="394"/>
            <end position="436"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
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        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
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        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
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        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000251-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="81344" checksum="F5752DD475E90760" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P043</accession>
    <name>A0A182P043_9DIPT</name>
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        <recommendedName>
            <fullName evidence="6">SOSS complex subunit A homolog</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
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        <text evidence="7">Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.</text>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 3 family.</text>
    </comment>
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    <dbReference type="STRING" id="199890.A0A182P043"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI000275"/>
    <dbReference type="Proteomes" id="UP000075885">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587:SF7">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
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    </dbReference>
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        <property type="entry name" value="HEAT_Ints3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ints3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="59"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Ints3-like C-terminal" evidence="10">
        <location>
            <begin position="723"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="534"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1048"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
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            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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        </location>
    </feature>
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            <end position="642"/>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1061"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1158"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000275-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1207" mass="134424" checksum="32BCFAAEE4A7382A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0M8</accession>
    <name>A0A182P0M8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0M8"/>
    <dbReference type="STRING" id="199890.A0A182P0M8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000460-RA">
        <property type="protein sequence ID" value="AEPI000460-PA"/>
        <property type="gene ID" value="AEPI000460"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000460"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000460-PA"/>
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    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0M9</accession>
    <name>A0A182P0M9_9DIPT</name>
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        <recommendedName>
            <fullName evidence="7">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">Epiroticus2</strain>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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                <person name="Howell P."/>
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                <person name="Zeng Q."/>
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                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
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                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Poon T.W."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">Epiroticus2</strain>
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        <source>
            <strain evidence="5">Epiroticus2</strain>
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        <property type="entry name" value="Cortactin-binding_p2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23166:SF5">
        <property type="entry name" value="CTTNBP2 N-TERMINAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23166">
        <property type="entry name" value="FILAMIN/GPBP-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09727">
        <property type="entry name" value="CortBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cortactin-binding protein-2 N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="104"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="221"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000519-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="563" mass="59981" checksum="F62B747F9C92E616" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P101</accession>
    <name>A0A182P101_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 184B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P101"/>
    <dbReference type="STRING" id="199890.A0A182P101"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000583-RA">
        <property type="protein sequence ID" value="AEPI000583-PA"/>
        <property type="gene ID" value="AEPI000583"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000583"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000583-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50030" checksum="579BD8576F25002D" modified="2016-09-07" version="1">MFAPVVLGWIYQHLRWYTNPQEQRWIVRILFIVPIYATYSWVSLLFFNSESVYVYFFTVRDCYEAFVIYNFLSLCYEYLGGEGNIMSEIRGKPIKSSCLYGTCCLAGKTYTIGFLRFCKQATLQFCLVKPLMAFIIIFLQAFNHYHDGDWSADGGYIYITVIYNISVSLALYGLYLFYFATRDLLTPFDPVLKFCTVKSVIFLSFWQGVGLAILEKAEVISPIVDAGGSTTSAGTVSAGYQNFFICIEMLFAAIALRYAFPYQVYAQSCMTDAHGRSVTMQSISSSLKETMNPKDIMTDAIHNFHPQYQQYTQYSSDCPSPIDRKRRESNHFQAAQYLKSYYQLRGKNPRGIRVSSYDPDDPSHQLTGGHGQGHGVGSGATTGSYNGNGASGGGSGGGGHGGSYIAPPTLGSQRKFMPGASVVPQKVSTISQNYNEKTMLLSSDDEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P153</accession>
    <name>A0A182P153_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P153"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000635-RA">
        <property type="protein sequence ID" value="AEPI000635-PA"/>
        <property type="gene ID" value="AEPI000635"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000635"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF40">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000635-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="75456" checksum="B922D98A21B68A10" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P189</accession>
    <name>A0A182P189_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Short gastrulation</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the chordin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P189"/>
    <dbReference type="STRING" id="199890.A0A182P189"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000671-RA">
        <property type="protein sequence ID" value="AEPI000671-PA"/>
        <property type="gene ID" value="AEPI000671"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000671"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016353">
        <property type="entry name" value="Chordin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052278">
        <property type="entry name" value="Chordin-like_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010895">
        <property type="entry name" value="CHRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46526">
        <property type="entry name" value="CHORDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46526:SF1">
        <property type="entry name" value="CHORDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002496">
        <property type="entry name" value="Chordin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00754">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50933">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="CHRD" evidence="11">
        <location>
            <begin position="73"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="CHRD" evidence="11">
        <location>
            <begin position="216"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="CHRD" evidence="11">
        <location>
            <begin position="468"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="10">
        <location>
            <begin position="620"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="905"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="908"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000671-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="928" mass="102279" checksum="99DA21FDB1B2E71F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1J8</accession>
    <name>A0A182P1J8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U4/U6 small nuclear ribonucleoprotein Prp31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-processing factor 31</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1J8"/>
    <dbReference type="STRING" id="199890.A0A182P1J8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000780-RA">
        <property type="protein sequence ID" value="AEPI000780-PA"/>
        <property type="gene ID" value="AEPI000780"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000780"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="13">
        <location>
            <begin position="235"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000780-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="514" mass="57265" checksum="1C1459FCF4EB9460" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2C2</accession>
    <name>A0A182P2C2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heparan-sulfate 6-O-sulfotransferase</fullName>
            <ecNumber evidence="7">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>alpha-D-glucosaminyl-[heparan sulfate](n) + 3'-phosphoadenylyl sulfate = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56604"/>
            <dbReference type="Rhea" id="RHEA-COMP:9830"/>
            <dbReference type="Rhea" id="RHEA-COMP:14621"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:58388"/>
            <dbReference type="ChEBI" id="CHEBI:140604"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sulfotransferase 6 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A182P2C2"/>
    <dbReference type="STRING" id="199890.A0A182P2C2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001056-RA">
        <property type="protein sequence ID" value="AEPI001056-PA"/>
        <property type="gene ID" value="AEPI001056"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001056"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017095">
        <property type="term" value="F:heparan sulfate 6-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010635">
        <property type="entry name" value="Heparan_SO4-6-sulfoTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12812">
        <property type="entry name" value="HEPARAN SULFATE 6-O-SULFOTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12812:SF0">
        <property type="entry name" value="HEPARAN-SULFATE 6-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001056-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="162" mass="17892" checksum="8B893C15D25CD931" modified="2016-09-07" version="1">MKKVMIPSLDMKKSISVKVDSDLTLLLSSGVYEIKKMEPRWRLRRPIIIVCLFLTIAGIIGFGYYCPDQVCALSRRDVTSSAGLGMSGGGSGPELTAGYEHDNLGKPVQQNLLANPGLSYEEVLNDDFQFDMNAHDVMVFLHIQKTGGTSFGKHLVRDLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2N0</accession>
    <name>A0A182P2N0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Probable methyltransferase required to silence rDNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
            <location evidence="1 13">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A182P2N0"/>
    <dbReference type="STRING" id="199890.A0A182P2N0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001164-RA">
        <property type="protein sequence ID" value="AEPI001164-PA"/>
        <property type="gene ID" value="AEPI001164"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001164"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005677">
        <property type="term" value="C:chromatin silencing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046015">
        <property type="term" value="P:regulation of transcription by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000068">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 13" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001164-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="354" mass="39706" checksum="09CCC57151404D55" modified="2016-09-07" version="1">KEKKQKKTKGKPENDGEVEGNVQSTNSKTNAGWSVLLKPPKSNVAERQKDTDNPNDPLKDDKRKGRKRKADNVTNGDGEKVIDNTTGKTGNKKVKPNDTAMVNGTNRPIPNGAKTSEKSTSTNQKKPVKEAFKSDNLRDKLVESLKGSRFRFINEQLYKIPGEEAKKMFQQDPASFKAYHDGYRLQVEQWPMNPLDRMIKSIQKMPKDTIVADFGCGEAKLAASVQQKVYSLDLVSNNNGVIACDMANTPLESNFVNVVVFCLSLMGTNLVDFLLEANRVLKVGGILKIAEVASRFENVNEFVNNVKKCGFELGTKDLKNKLFYFFIFKKNRTVLKGSTKIKPFSLKPCLYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2W0</accession>
    <name>A0A182P2W0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FYVE-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2W0"/>
    <dbReference type="STRING" id="199890.A0A182P2W0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001246-RA">
        <property type="protein sequence ID" value="AEPI001246-PA"/>
        <property type="gene ID" value="AEPI001246"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001246"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001246-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22365" checksum="364FEF6A4A52AC9A" modified="2016-09-07" version="1">MCNANIELETTDSFATCRGCEKLVCRGENCCQWVESIGIWECTGCQSNRVIQQKAGEWLLNQLTVRLKHPGPVELGKDGNLLGLGLDNDDARSTASSSTVSANQRIKVREFIEELLSAMLHGPLDDVSVGQLMKHESYVRLFRKFHTRLSRCLYNLELSIHHSLMSGKKNQCQTDSSKHEHRQSMITRSFPSSVHLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3A9</accession>
    <name>A0A182P3A9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fuzzy</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the fuzzy family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016192">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026069">
        <property type="entry name" value="Fuzzy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13559">
        <property type="entry name" value="INTRACELLULAR TRAFFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR13559:SF1">
        <property type="entry name" value="PROTEIN FUZZY HOMOLOG"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="405" mass="45722" checksum="5870F570D0B014C1" modified="2016-09-07" version="1">MSIHLMCLTSDGGVPIYSKKRGDTETLPFSTIASLNGVHMFCKSQGVDLPITYLEDSMIMWKEFEGTIVMIGIARDITEKTLRHLLDYSYQAMVFCVGIQSIKKIKNIDRFKRELKNYYPLIDQLLEVVESDLFRYVDCVLCSESMAMLTKLNEFSVQIGSPFCAIMVRQRIACGTEGWWDLDVIDRKLLMLLLNASSTIQQDVPVYLPKKSPSIAYRFISIPLTQGVSICALCGAEPKYDVLQGLSQQFWMAELDMLIAAEQKYPKSYPASVELDSHILGFLLLNREHAKYVLSRGAQTLNNAPGGKSRSGTIGTGGSSSTHRLDILRSFFHQSVDVMEDTLREGDRVMNLEQYWCSDYHKCHALIEGSNVLCVLYTSAIPTHIMRIVTQKTLNTLISDKDVCW</sequence>
</entry>
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    <name>A0A182P3U3_9DIPT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Epiroticus2</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
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        <property type="gene ID" value="AEPI001579"/>
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    </dbReference>
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    <sequence length="2243" mass="230283" checksum="C5821B2DC5699C58" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3V8</accession>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3V8"/>
    <dbReference type="STRING" id="199890.A0A182P3V8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001594-RA">
        <property type="protein sequence ID" value="AEPI001594-PA"/>
        <property type="gene ID" value="AEPI001594"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001594"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13130">
        <property type="entry name" value="34 KDA TRANSCRIPTIONAL CO-ACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13130:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001594-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="36192" checksum="09AAECFC3703D0BC" modified="2023-06-28" version="2">MNVNTKPPPGSRIIENLPKTMNLEPINNALSQLRVLRSSVGQVFDTLGTGVRADHGEEGKEQKFLQELQELLNSVNANLKDFESSINDLTPPQTPLNLANSAYLSLETNLERQALYPHLVQSYKWHDKLHEYSTFASTLLQQNSLKRSYYTNTKRRRSLPSSHLATPQMVENLIGSIHYNNMNLKIARPFMTNAILHITIARVLRAAVILKGLLIEWVTVKGYEESLLDGVDEQWTESRHQVFRKVQDHAHSAMLHFFSPTLPELAIRSFITWFRSYVTLFADPCKKCGKHLHNTLPPTWRDLRTLEPFHEECKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P409</accession>
    <name>A0A182P409_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Terribly reduced optic lobes</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P409"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001645-RA">
        <property type="protein sequence ID" value="AEPI001645-PA"/>
        <property type="gene ID" value="AEPI001645"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001645"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002299">
        <property type="entry name" value="AGAP003656-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002808">
        <property type="entry name" value="AGAP003656-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000044">
        <property type="entry name" value="Basement membrane-specific heparan sulfate proteoglycan core protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000106">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000062">
        <property type="entry name" value="Terribly reduced optic lobes, isoform AI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000086">
        <property type="entry name" value="Terribly reduced optic lobes, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000065">
        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000137">
        <property type="entry name" value="Uncharacterized protein, isoform AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF63">
        <property type="entry name" value="TERRIBLY REDUCED OPTIC LOBES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="12 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 16" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="408"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="673"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="20">
        <location>
            <begin position="771"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="20">
        <location>
            <begin position="1138"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="1353"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="20">
        <location>
            <begin position="1484"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="1736"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="1833"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="1930"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="2030"/>
            <end position="2111"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="2119"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="2209"/>
            <end position="2298"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="2328"/>
            <end position="2407"/>
        </location>
    </feature>
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    <sequence length="2563" mass="283911" checksum="8681AD0BD9837F51" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4C8</accession>
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            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
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            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="8">Epiroticus2</strain>
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        <source>
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    </evidence>
    <sequence length="313" mass="35097" checksum="2C584C538DD3A174" modified="2016-09-07" version="1">MGLSTAQTQLRRQYELNRRTPGSGPAAAVRNRAPAAAAAAAADEPVRSTVRQQGPVQPSGSEEIDPELSENCPEPNGYFADAEQCDKYYQCRDGQITEKLCPDGMVFNDYDSDQEKCDLPFNIDCSKRPKLQTPIPSLHCPRQNGYFASETGACDKFYYCVDGMFNMITCPEGLVFNPRTGICTWPDEAQKKGCSSEDVFKFTCPKVNETEAATHPRYADPDDCQFFYVCINGETPRRNGCKLGQAFDDVAKHCEWARKVPDCADWYKDRLTDKQLEELENPPTPKPKPANSPSKVSRRRPSKRPKQPVDELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4I0</accession>
    <name>A0A182P4I0_9DIPT</name>
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        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4I0"/>
    <dbReference type="STRING" id="199890.A0A182P4I0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001816-RA">
        <property type="protein sequence ID" value="AEPI001816-PA"/>
        <property type="gene ID" value="AEPI001816"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001816"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23064">
        <property type="entry name" value="PDZ3_INAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF93">
        <property type="entry name" value="INACTIVATION-NO-AFTER-POTENTIAL D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="89"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="303"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="409"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="548"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="643"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001816-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="730" mass="79115" checksum="C7CF6F564E71B66E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P565</accession>
    <name>A0A182P565_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MOB kinase activator-like 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P565"/>
    <dbReference type="STRING" id="199890.A0A182P565"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002053-RA">
        <property type="protein sequence ID" value="AEPI002053-PA"/>
        <property type="gene ID" value="AEPI002053"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002053"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000001">
        <property type="entry name" value="MOB kinase activator 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002053-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24962" checksum="430710E38E525C07" modified="2016-09-07" version="1">MSFLFRSSKTFKPKKNIPEGTHQYDLMKHAAATLGSGNLRNAVQLPDGEDLNEWVAVNTVDFFNQINMLYGTITEFCTEDTCSIMSAGPKYEYHWADGQTVKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFINIAKTILKRLFRVYAHIYHQHFSEVVRLSEEAHLNTSFKHFIYFVQEFNLIDRRELAPLQDLIDKLITKDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P569</accession>
    <name>A0A182P569_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4794 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P569"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002057-RA">
        <property type="protein sequence ID" value="AEPI002057-PA"/>
        <property type="gene ID" value="AEPI002057"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002057"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031983">
        <property type="entry name" value="DUF4786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16027">
        <property type="entry name" value="DUF4786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130977" description="DUF4794 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002057-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45001" checksum="CF94A32C4CB5695B" modified="2016-09-07" version="1">MTQASRVIVLLCLVSTVAAIPVRQSQLLAAMQRQYDARSGKETGGYLQELETDANGQEQPAESGKVSADAEPEPSASSTGNREPLLPLPNLRKNKMLGYFGLYSPAALSAAAAAAYAQPYGYPLYHSMLDYYDDYLPVDNYPSLNMLANMQTYPQNLYANMANGMGSYQTMSNLSPNLQQQLNSLVQQQQLSQQQQQQQQQQQQQQSANPQLANLAGLDANAASLGSFQSLAASFAAGNDNFQGLDDEDILSRHSQAGRRRPAVKNSPIYYIRLPPTPYMFVPGVGYISQPPTIQPMAAPVPQYPQLAPPPSPVTMSPFYQLPINFVSNGKPSGIYQWNGAAAAPAAPPQPTFALPYPRPQRPAFAPSPFIQDSKITHLKGPFLFNGRPEEIFLLQNTFNPLFQSPLNSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5M9</accession>
    <name>A0A182P5M9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5M9"/>
    <dbReference type="STRING" id="199890.A0A182P5M9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002219-RA">
        <property type="protein sequence ID" value="AEPI002219-PA"/>
        <property type="gene ID" value="AEPI002219"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002219"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF9">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="5">
        <location>
            <begin position="160"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002219-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="620" mass="71278" checksum="9927C75CAA7985E7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6G8</accession>
    <name>A0A182P6G8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6G8"/>
    <dbReference type="STRING" id="199890.A0A182P6G8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002516-RA">
        <property type="protein sequence ID" value="AEPI002516-PA"/>
        <property type="gene ID" value="AEPI002516"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002516"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002516-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="89" mass="10201" checksum="CA892CCBC670D298" modified="2016-09-07" version="1">MPVCMAGYNEKRLLHDLLDSYNILERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLVTNIWLKLVSTIDNAWLPGSSESKRGPNERKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6K0</accession>
    <name>A0A182P6K0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EMAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6K0"/>
    <dbReference type="STRING" id="199890.A0A182P6K0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002548-RA">
        <property type="protein sequence ID" value="AEPI002548-PA"/>
        <property type="gene ID" value="AEPI002548"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002548"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21931">
        <property type="entry name" value="TD_EMAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000320">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001322">
        <property type="entry name" value="Echinoderm microtubule-associated protein-like CG42247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049813">
        <property type="entry name" value="Elp-1-like_TD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005108">
        <property type="entry name" value="HELP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF50">
        <property type="entry name" value="ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03451">
        <property type="entry name" value="HELP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EML-like first beta-propeller" evidence="10">
        <location>
            <begin position="348"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="625"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="11">
        <location>
            <begin position="632"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="754"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="866"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002548-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="901" mass="98438" checksum="72717BE619997EC7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7H3</accession>
    <name>A0A182P7H3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly factor 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in an early step of the mitochondrial complex IV assembly process.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7H3"/>
    <dbReference type="STRING" id="199890.A0A182P7H3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002875-RA">
        <property type="protein sequence ID" value="AEPI002875-PA"/>
        <property type="gene ID" value="AEPI002875"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002875"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002875-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="87" mass="10066" checksum="84B732F6AFB56EEF" modified="2016-09-07" version="1">MMRYEGNEELADKSACAGVRADLKMCLLQSDCCKKEKKTPRECLNRTDGSVPSECFVLRNTFFECKRSMVSGRDLDNRQRFRGRKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7Q1</accession>
    <name>A0A182P7Q1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7Q1"/>
    <dbReference type="STRING" id="199890.A0A182P7Q1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002954-RA">
        <property type="protein sequence ID" value="AEPI002954-PA"/>
        <property type="gene ID" value="AEPI002954"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002954"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131058" description="Peptidase S1 domain-containing protein" evidence="9">
        <location>
            <begin position="34"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="47"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="314"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002954-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="575" mass="64452" checksum="F8AFF8EDD50C6133" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7W8</accession>
    <name>A0A182P7W8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7W8"/>
    <dbReference type="STRING" id="199890.A0A182P7W8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003021-RA">
        <property type="protein sequence ID" value="AEPI003021-PA"/>
        <property type="gene ID" value="AEPI003021"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003021"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000011">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component DHKTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="564"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003021-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="918" mass="103254" checksum="42F0215570C8F5FA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7Y1</accession>
    <name>A0A182P7Y1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7Y1"/>
    <dbReference type="STRING" id="199890.A0A182P7Y1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003034-RA">
        <property type="protein sequence ID" value="AEPI003034-PA"/>
        <property type="gene ID" value="AEPI003034"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003034"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF104">
        <property type="entry name" value="MATERNAL GENE REQUIRED FOR MEIOSIS, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="612"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="793"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="934"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003034-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1039" mass="107243" checksum="31E906780FAE22C3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P814</accession>
    <name>A0A182P814_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cysteine proteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P814"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003067-RA">
        <property type="protein sequence ID" value="AEPI003067-PA"/>
        <property type="gene ID" value="AEPI003067"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003067"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000130">
        <property type="entry name" value="Cysteine proteinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="3" id="KW-0645">Protease</keyword>
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    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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        <location>
            <begin position="22"/>
            <end position="1923"/>
        </location>
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        <location>
            <begin position="1518"/>
            <end position="1575"/>
        </location>
    </feature>
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        <location>
            <begin position="1608"/>
            <end position="1826"/>
        </location>
    </feature>
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            <begin position="27"/>
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        </location>
    </feature>
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            <begin position="229"/>
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        </location>
    </feature>
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        </location>
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            <begin position="584"/>
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        </location>
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        <location>
            <begin position="773"/>
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        </location>
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            <begin position="1013"/>
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        </location>
    </feature>
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            <begin position="1464"/>
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        </location>
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            <begin position="27"/>
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        </location>
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            <begin position="237"/>
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        </location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003067-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1923" mass="213412" checksum="B6A2FF81DDC1E64C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P872</accession>
    <name>A0A182P872_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium channel voltage dependent KCNQ C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P872"/>
    <dbReference type="STRING" id="199890.A0A182P872"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003125-RA">
        <property type="protein sequence ID" value="AEPI003125-PA"/>
        <property type="gene ID" value="AEPI003125"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003125"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013821">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF9">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03520">
        <property type="entry name" value="KCNQ_channel"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003125-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="210" mass="22857" checksum="C3859150D9338D9C" modified="2016-09-07" version="1">LDQILGKQGSKSKDVYASKISLASRVVKIERQVDDIETKVDSFIDLYMQDRMRLLSLPLHPDTSHSNNPNLPSLPPKGGGAAAVITSVTTSSSGSLKPKPILVDKQFSEPNSPIAKTFEEQPLQQKRPPMQRGFSDLGHRIKKRVTLSSIPPQYVGNSTGQPAERGDVVIVVPNIDTEHLEPVGIEELASVCIDTEIEIEPGSPKTITES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P894</accession>
    <name>A0A182P894_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P894"/>
    <dbReference type="STRING" id="199890.A0A182P894"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003147-RA">
        <property type="protein sequence ID" value="AEPI003147-PA"/>
        <property type="gene ID" value="AEPI003147"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003147"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130992" evidence="3">
        <location>
            <begin position="17"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
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        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
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        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="371"/>
        </location>
    </feature>
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        <location>
            <begin position="375"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
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        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
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        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003147-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="824" mass="89686" checksum="EE66BB6B0A700480" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P899</accession>
    <name>A0A182P899_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase F1 subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P899"/>
    <dbReference type="STRING" id="199890.A0A182P899"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003152-RA">
        <property type="protein sequence ID" value="AEPI003152-PA"/>
        <property type="gene ID" value="AEPI003152"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003152"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000007">
        <property type="entry name" value="ATPase inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003152-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="105" mass="11679" checksum="2CDA60C0B39B22E3" modified="2016-09-07" version="1">MQSLRKTTTWMIPSGMRIARMSAGEMGSGAGKGGGGGGSIRDAGGSFGKMEVAHEEEYFYKQRQEQLAKLKQKAINHEDFHSESIKHHEEAIARHKKAIEELKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8A0</accession>
    <name>A0A182P8A0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P8A0"/>
    <dbReference type="STRING" id="199890.A0A182P8A0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003153-RA">
        <property type="protein sequence ID" value="AEPI003153-PA"/>
        <property type="gene ID" value="AEPI003153"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003153"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35685:SF2">
        <property type="entry name" value="825-OAK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35685">
        <property type="entry name" value="825-OAK-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131091" evidence="1">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003153-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="119" mass="11724" checksum="80AC2FDE56ED132D" modified="2016-09-07" version="1">MFAKVIIFVAIAVACAAGKPLTAAVVAAPAVVTAQSSQVFARNYNGVAAAYTAPAVVSAAYTAPVAAAYTAPVAAAYTAYASPVAAAYTTAPVAAAAYSAPLTAAYTAASYAPYYPYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8C2</accession>
    <name>A0A182P8C2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCAPER_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P8C2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003175-RA">
        <property type="protein sequence ID" value="AEPI003175-PA"/>
        <property type="gene ID" value="AEPI003175"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003175"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032446">
        <property type="entry name" value="SCAPER_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434:SF2">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16501">
        <property type="entry name" value="SCAPER_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S phase cyclin A-associated protein in the endoplasmic reticulum N-terminal" evidence="2">
        <location>
            <begin position="66"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003175-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1396" mass="156215" checksum="383E832F2BB2335A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8I9</accession>
    <name>A0A182P8I9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <location evidence="18">Coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P8I9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003242-RA">
        <property type="protein sequence ID" value="AEPI003242-PA"/>
        <property type="gene ID" value="AEPI003242"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003242"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000092">
        <property type="entry name" value="LDL receptor related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000155">
        <property type="entry name" value="Low-density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000189">
        <property type="entry name" value="low-density lipoprotein receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000024">
        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000181">
        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000230">
        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000132">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000004">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000005">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000035">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000040">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000045">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000078">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000121">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000188">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000204">
        <property type="entry name" value="Putative low-density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000030">
        <property type="entry name" value="Sortilin related receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000062">
        <property type="entry name" value="Terribly reduced optic lobes, isoform AI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000065">
        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056588">
        <property type="entry name" value="EGF_LRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032485">
        <property type="entry name" value="LRP1-like_beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16472">
        <property type="entry name" value="DUF5050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24468">
        <property type="entry name" value="EGF_LRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="38"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0168">Coated pit</keyword>
    <keyword evidence="14 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="4446"/>
            <end position="4466"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="524"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="713"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="843"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="1499"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="1544"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="2182"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="2226"/>
            <end position="2267"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="2455"/>
            <end position="2495"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="2496"/>
            <end position="2542"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="2543"/>
            <end position="2584"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="3279"/>
            <end position="3320"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="3367"/>
            <end position="3410"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="4153"/>
            <end position="4201"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="4202"/>
            <end position="4245"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="21">
        <location>
            <begin position="4247"/>
            <end position="4290"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="4388"/>
            <end position="4429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="4495"/>
            <end position="4515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="4604"/>
            <end position="4638"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1012"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1045"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1052"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1064"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1084"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1091"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1144"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1184"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1228"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="4638" mass="514480" checksum="2F61B248F34F1AF5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8W0</accession>
    <name>A0A182P8W0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="199890.A0A182P8W0"/>
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        <property type="protein sequence ID" value="AEPI003364-PA"/>
        <property type="gene ID" value="AEPI003364"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003364"/>
    <dbReference type="Proteomes" id="UP000075885">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003364-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="215" mass="24840" checksum="6B8748C1453E547E" modified="2016-09-07" version="1">MEQLIQNQMISAAVQLEKHLDSELDRLETLNADDLEKLREQRIQQLKKQAQQRQEWKSNGHGEYAELADEKEFFAISKKSPNIVCHFYRDSTPRCRIVDMHLKVLASKHLEARFCKVNAERCPFLTERLRIKVIPSIALIKDSKTKDYIVGFTDLGNCDDFSTEMLEWRIAQSGAIEYSGDLLTPPDVKKQKKPSNMKTIRGGYDSDDSDIDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
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    <name>A0A182P9M5_9DIPT</name>
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        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P9M5"/>
    <dbReference type="STRING" id="199890.A0A182P9M5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003630-RA">
        <property type="protein sequence ID" value="AEPI003630-PA"/>
        <property type="gene ID" value="AEPI003630"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003630"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003630-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="205" mass="23402" checksum="196EF961A7A88205" modified="2016-09-07" version="1">MEKGAVNKTGIYRLKLPFNATTEVLCDAEYDKGGWVVIQHRFNGSEDFFRNWTDYETGFGALDGEFWLGNEKIYQLTAEKPREMAILMEDFDGKKAEARYATFKMGDKAEKYTLKSLGSFSGTAGDSLSRNVGSKFSTRDADNDKSDSHCAQLYFGGWWYDNCHLSNLNGKYMKGPTTVYAVSMCWNSFRGFHYSLKTSRIMVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAA9</accession>
    <name>A0A182PAA9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAA9"/>
    <dbReference type="STRING" id="199890.A0A182PAA9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003863-RA">
        <property type="protein sequence ID" value="AEPI003863-PA"/>
        <property type="gene ID" value="AEPI003863"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003863"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003863-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="235" mass="26465" checksum="6B50BF3674082C1B" modified="2016-09-07" version="1">MSDSDSSDNEINAQLLSAVDTSFLNDKLYTDQTTSKNADSPAHSQAVKSSPVPEVVKKTVLKSNRFLDEEDFTFHSELKVPVAMQKHTAEKLSKLISAVIEFDDTESKPNSTNGSTEVSGVRLLTGFDEIVDINLEEELPPCVPLKKIPIVRRQVEDEVKITTADKIVACVCDPLAFPKEVQEWKGPRKRSVEFKYKQKPNGTIVEKVDPFANEFTKARNANQWHESKIRKFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAH0</accession>
    <name>A0A182PAH0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xanthine/uracil transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAH0"/>
    <dbReference type="STRING" id="199890.A0A182PAH0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003924-RA">
        <property type="protein sequence ID" value="AEPI003924-PA"/>
        <property type="gene ID" value="AEPI003924"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003924"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003924-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="62409" checksum="3EA82D861A241DC0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAH2</accession>
    <name>A0A182PAH2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAH2"/>
    <dbReference type="STRING" id="199890.A0A182PAH2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003926-RA">
        <property type="protein sequence ID" value="AEPI003926-PA"/>
        <property type="gene ID" value="AEPI003926"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003926"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="212"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="306"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003926-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="458" mass="51625" checksum="35BB946DA3CD8F53" modified="2016-09-07" version="1">MKLPVQNKNKQVQALGKLHKATNKMPIKQSVALKSATPVKAAQVQKVKMALQSKKGAVAVGKTVLSKKMKVKVEEPESEEEDEESEVNDEEEDSDAFDESEEDMDSEMNDEEEDIDASGEEQEEEEDASDEEQEEEDDASDEGLAEELNESAEERKDDSGEENDPHCKNDEADEQANVETVKQSLKLETKNVAEKEAKSKLNSMDMVHGPEYSIFIGNLPKTLKDGQLKTIFGKYGKILTIRRRTITGERILTKKNLDSITTVNAYVRFSTKEEMLKACEMNGQEVGGNHIRVCPHYQKQIGQVNSTVFVGNIKIGTTQNDLYDFFSKVGPIEYIRYMPNKCFAFVCFGKGVSTMKALKLNQEPLNGRPLRIEKIDKERNNVKLNKKGHVVPRKRLPEHNKPHNKGGQRNNANLGKNFHGKVAEKKKSQKPSNSKLQKIMIAKKLKAAMDKKMAERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAI1</accession>
    <name>A0A182PAI1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAI1"/>
    <dbReference type="STRING" id="199890.A0A182PAI1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003935-RA">
        <property type="protein sequence ID" value="AEPI003935-PA"/>
        <property type="gene ID" value="AEPI003935"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003935"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19708">
        <property type="entry name" value="bHLH_TS_dHLH3B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000015">
        <property type="entry name" value="T-cell acute lymphocytic leukemia 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040238">
        <property type="entry name" value="TAL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864:SF15">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="150"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003935-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="405" mass="44200" checksum="6C73C5501397D56C" modified="2016-09-07" version="1">MENNVSSDIDMSKLGESAKGLLTTFENANASLMASALVSSVQFTTAAKEVPDALRHSDCDVQARPDGCFSRSPMQDLSDDEMSDFSSNESDGMEELDLKNAGHGRSAEEEPSGSIHDSGSSLGSVMPVLNLAGTKLGIGASGINGTGAVVRKMFTNTRERWRQQNVSGAFAELRKLVPTHPPDKKLSKNEILRMAIRYIRLLTNVLEWQKKQEANDLRTPLKQRSSQQQLLSITQMSAQVMQQQHPNNENHFTGNYRENGNNLLMIVSPKSFAKSTSSSSRTVKLESKMEQCVEIEKIKLVSKLCPPGKVTKPGNVVSGCGKSRRKTMCSTVHVRGGLHVKTDLMALSQPYGSVVPTIMESEIKRELTHHSQMAASDGAGHSRAYLNGEGNTHSNANEKGLEKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBA5</accession>
    <name>A0A182PBA5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBA5"/>
    <dbReference type="STRING" id="199890.A0A182PBA5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004210-RA">
        <property type="protein sequence ID" value="AEPI004210-PA"/>
        <property type="gene ID" value="AEPI004210"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004210"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131199" evidence="1">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004210-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="198" mass="21134" checksum="67393A56C640795E" modified="2016-09-07" version="1">MRIIIAQLLSATVLLQPLLAAPIFWFLPWSFPALPTTTTISSTAATSGTGTGGASNSSNVSVAIGNRVNTSTGLDDYGTNITNVQINVNRMRRAVTSADLARLERQLRQTETPGDTSTNGTVITIGEHTIRLPSNISNLTVNTYLINGIPEDGMMMLPGTGSANPNEQAYTTTTPLLSAIRLLKNFFSSFFAKQTSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBB2</accession>
    <name>A0A182PBB2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBB2"/>
    <dbReference type="STRING" id="199890.A0A182PBB2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004217-RA">
        <property type="protein sequence ID" value="AEPI004217-PA"/>
        <property type="gene ID" value="AEPI004217"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004217"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131087" description="Fibrinogen C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="234"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004217-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="451" mass="51227" checksum="F8EFDD9B0550046C" modified="2016-09-07" version="1">MRKFLLVLTLALALASANTTEDKEDKVPEEIIEEIKASDDKPADDDDDLRGYGYYNVVHGPHGHGGDSEEHGYRPTNFAPSKIGYGGGGYDGGYGGGYGGSYPTRPPPRPDPEYDFPKPKPPPKCNCKDIIDQIDDLDEKIIKSLLDLEIKADGIETDVAHIHKETEKVAFVSSQTQLIANAVDNQLNIVRQNLTIIQSDVEELTQFQQNIPDRTYLTEALFGLKCSYARKSKPQDDRIYASCEDPNIKKTGSYWIKANFYKPVKVICMLDYGGRWMVIQNRFDGSVDFYRPWREYKYGFGNNEGGEYWLGLDRIYQFTKGGAAQLLIVLEDFEKNVTYARYDQFAISDENDQYKILKLKGFIGSAGDSFEAEGMRFSTYDYDNDKFDQNCAAITHGAWWYKSCGESNLNGLYLNGPTLEKTGIYWNSFRGYNYSLKKTRMMIRQRDGPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBE3</accession>
    <name>A0A182PBE3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B14.5a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase subunit B14.5a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA7 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBE3"/>
    <dbReference type="STRING" id="199890.A0A182PBE3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004248-RA">
        <property type="protein sequence ID" value="AEPI004248-PA"/>
        <property type="gene ID" value="AEPI004248"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004248"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009947">
        <property type="entry name" value="NDUA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07347">
        <property type="entry name" value="CI-B14_5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004248-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="83" mass="9247" checksum="D269AF465416EBBE" modified="2016-09-07" version="1">MSGVVRRDISPMLQKLRNFLLGRQHTNALRFEDGIAARTQPPPNLPDGPAHKLSANHYVIRDARREVAPPIDLTAQKLLAEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBG0</accession>
    <name>A0A182PBG0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PBG0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004265-RA">
        <property type="protein sequence ID" value="AEPI004265-PA"/>
        <property type="gene ID" value="AEPI004265"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004265"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000009">
        <property type="entry name" value="TBC1 domain family member 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032738">
        <property type="entry name" value="Tbc1d30_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399:SF2">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN TRAP , GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15733">
        <property type="entry name" value="DUF4682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="55"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1461"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1608"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1435"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1529"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1550"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1625"/>
            <end position="1634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004265-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1722" mass="190789" checksum="EBC76F5FC83CA0F8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC31</accession>
    <name>A0A182PC31_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DZF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PC31"/>
    <dbReference type="STRING" id="199890.A0A182PC31"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004487-RA">
        <property type="protein sequence ID" value="AEPI004487-PA"/>
        <property type="gene ID" value="AEPI004487"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004487"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002080">
        <property type="entry name" value="Zinc finger RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000210">
        <property type="entry name" value="Zinc finger RNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762:SF3">
        <property type="entry name" value="ZINC-FINGER PROTEIN AT 72D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZF" evidence="2">
        <location>
            <begin position="325"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004487-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="750" mass="80041" checksum="EA1851CBFE8BD86B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC62</accession>
    <name>A0A182PC62_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L27a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC62"/>
    <dbReference type="STRING" id="199890.A0A182PC62"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004517-RA">
        <property type="protein sequence ID" value="AEPI004517-PA"/>
        <property type="gene ID" value="AEPI004517"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004517"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="7">
        <location>
            <begin position="74"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004517-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="151" mass="17126" checksum="564C98A089CDC63F" modified="2016-09-07" version="1">MVSLKVRRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGMHHHRINFDKYHPGYFGKVGMRNFHLNRNHKFCPTINLSHLWSLVPEKVREEAKKNPEKVPVVDLVQFGYYKLLGSGGFGFPKAPIIVKAKYFSRKAEERIKACGGACVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC66</accession>
    <name>A0A182PC66_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein SPEC3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC66"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004521-RA">
        <property type="protein sequence ID" value="AEPI004521-PA"/>
        <property type="gene ID" value="AEPI004521"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004521"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071683">
        <property type="term" value="C:sensory dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019230">
        <property type="term" value="P:proprioception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050954">
        <property type="term" value="P:sensory perception of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042330">
        <property type="term" value="P:taxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026673">
        <property type="entry name" value="SPEC3/Stum"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676">
        <property type="entry name" value="PROTEIN STUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676:SF6">
        <property type="entry name" value="PROTEIN STUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15795">
        <property type="entry name" value="Spec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004521-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25378" checksum="3A134EC7C26D9B2A" modified="2016-09-07" version="1">MEEPVEMETVKCCFCFKRQRPKVKAKPKKKVPVKSTFNCLSCCMMCCKKKGDNQSRRTSNLSKKQSIAPTIPPEDLRPKIDMSLVEHSSLMRGAIPVLPICLAYFCLFLNVVVPGSGTVLSGGLCLCIGKPRFSQHDSIKGRIGSFIINCIVGVSQCFTIIFCVVGWGWAIWWGTIMLRLARQHRKILEMEAAQEEGEEQTTLSNRTGASNPPVALVSKTHRDVETGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC72</accession>
    <name>A0A182PC72_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC72"/>
    <dbReference type="STRING" id="199890.A0A182PC72"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004527-RA">
        <property type="protein sequence ID" value="AEPI004527-PA"/>
        <property type="gene ID" value="AEPI004527"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004527"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF61">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="108"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="110"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004527-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="182" mass="21364" checksum="585C7C7B39E82C8F" modified="2016-09-07" version="1">MGICLVLQQAGNVERLGRFLWSLPQCDKLQLHESVLKAKAVVAFHRGNFKELYRLLEHHQYSPHNHAKLQALWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRSVLRDWYTHNPYPSPREKRELAEATGLTTTQVSQAKFGQVSVSNWFKNRRQRDRAAEHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCB0</accession>
    <name>A0A182PCB0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCB0"/>
    <dbReference type="STRING" id="199890.A0A182PCB0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004565-RA">
        <property type="protein sequence ID" value="AEPI004565-PA"/>
        <property type="gene ID" value="AEPI004565"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004565"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF460">
        <property type="entry name" value="PROTON-COUPLED AMINO ACID TRANSPORTER 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="89"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004565-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="499" mass="55025" checksum="1326E680A273BC05" modified="2016-09-07" version="1">MISGQYAPTMGTCLTQIPRPVSNQIRPQLTGGSKSELTGYIFGRMKSELNDVPAQTAAGSTLPLVDMIKDDEEAGTYNPFENRKLTHPTTDMETLVHLLKGSLGSGILAMPLAFVNAGLWFGLIATVAIGAICTYCIHILVRCSHILCRRAQLPSLGFADVAEVAFLAGPEQLKKYSRLARFIINLFLVIDLVGCCCIYIVFVATNLKQVVDHYTHSYWDVRIYILMMLLPLIALNLIRKLKYLTPFSFIANVLIGAGVGITLYYIVTDLPALSERKAIAEVQHLPMFFGTVIFALEGIGVVMSLENNMKNPQNFIGCPGVLNTGMSVVVMLYATVGFLGYLKYGDETKGSITLNLPVEDVPAQMVKLMIAVAIFLTYALQFYVPMEIIWKNIKGNFNEHQNAAEYTLRIGLVILTVIIAAALPNLGPFITLIGAVCLSTLGLMFPAVIELVTFYEKPGFGRFNWILWKNVFLILFGVVGFVTGTYVSIMEFSEHLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCQ9</accession>
    <name>A0A182PCQ9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PCQ9"/>
    <dbReference type="STRING" id="199890.A0A182PCQ9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004714-RA">
        <property type="protein sequence ID" value="AEPI004714-PA"/>
        <property type="gene ID" value="AEPI004714"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004714"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061762">
        <property type="term" value="P:CAMKK-AMPK signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000429">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF164">
        <property type="entry name" value="CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="642"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="358"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="590"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="917"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="978"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="934"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="978"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="998"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="671"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004714-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1009" mass="108236" checksum="08FE3D16CFF93385" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCS7</accession>
    <name>A0A182PCS7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NR LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCS7"/>
    <dbReference type="STRING" id="199890.A0A182PCS7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004732-RA">
        <property type="protein sequence ID" value="AEPI004732-PA"/>
        <property type="gene ID" value="AEPI004732"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004732"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004732-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13411" checksum="5C9890F3BCE91FB9" modified="2016-09-07" version="1">MACIRQVRHNEHFAVFSRAQQNEILRHVWYECFLLRVANWSIDVSSLVERCCDAHLRSVVEDIKALRVDLIELSLLETLILCRKALRFNEFAVRAMLREVISDDGLALETILTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD42</accession>
    <name>A0A182PD42_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in innate immunity. Agglutinates all types of human erythrocytes, Gram-positive and Gram-negative bacteria. Has a stronger agglutinating activity towards Gram-negative bacteria than towards Gram-positive bacteria. Specifically recognizes acetyl group-containing substances on agglutinated cells. The hemagglutinating activity was inhibited by EDTA, acetyl group-containing mono- and disaccharides, N-acetyl derivatives of amino acids, other acetyl group-containing substances, propionamide and benzamide. Enhances the antimicrobial activity of big defensin against Gram-positive bacteria but not against Gram-negative bacteria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PD42"/>
    <dbReference type="STRING" id="199890.A0A182PD42"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004847-RA">
        <property type="protein sequence ID" value="AEPI004847-PA"/>
        <property type="gene ID" value="AEPI004847"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004847"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004847-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="235" mass="27341" checksum="4440EF5880ACA8B7" modified="2016-09-07" version="1">MASLAGYSCVDLMNAGMRQSGVYYLQIRGTTYWFLKVFCEQEIADGGWTVIQRRDDYGDPRENFNRDWADYKNGFGDPAKEFWLGNENIYMLTNNEDYSLRVELEDFEGNKRYAQYSHFKIHSEQDYYKLEIDGYEGNAGDSLNDPWYGSNNSPFSTYNRDNDRSSLNCASMLKGGWWWKSCGRGLNGLYLHDPQDLTARQGIVWFRWRGWDYTLKKATMMIKPKGPQPQVAGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PED7</accession>
    <name>A0A182PED7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PED7"/>
    <dbReference type="STRING" id="199890.A0A182PED7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005292-RA">
        <property type="protein sequence ID" value="AEPI005292-PA"/>
        <property type="gene ID" value="AEPI005292"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005292"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF102">
        <property type="entry name" value="ZINC FINGER PROTEIN 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005292-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="125" mass="14470" checksum="A8B0B23751A4E9C5" modified="2016-09-07" version="1">MMKQFNEKHSVLRHEDIEKKHKCDRCDFATHIPGHLRRHLLVHSGSKPFACPHCDYSCNNIENLRKHVISTSKHKGKFLYECKLCAHGTEGSTAPYGTNFQKEFKEHLQQCHDLSPDEVKMASIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PET4</accession>
    <name>A0A182PET4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PET4"/>
    <dbReference type="STRING" id="199890.A0A182PET4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005439-RA">
        <property type="protein sequence ID" value="AEPI005439-PA"/>
        <property type="gene ID" value="AEPI005439"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005439"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
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        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
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    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="531"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="186"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
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            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="676"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="760"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="880"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="961"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005439-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1201" mass="139971" checksum="781949E3F0B32BBB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFW4</accession>
    <name>A0A182PFW4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PFW4"/>
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        <property type="protein sequence ID" value="AEPI005823-PA"/>
        <property type="gene ID" value="AEPI005823"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005823"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005823-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="152" mass="17210" checksum="E597483D600BFE7D" modified="2016-09-07" version="1">MSNLSSSKANQTQQQDGKDVEAADMSQPSSSKTNQQQQQDGIDKGASSSTLCQPSTSKAHQLKQQQDASEHDAVNNRFIERREPTVAYCIACRSEFTFSLTTDIIQHYLSRRHEPSCRCLYCNGPMYQYLTGKNELQYYHDCHRSKHGLDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH22</accession>
    <name>A0A182PH22_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PH22"/>
    <dbReference type="STRING" id="199890.A0A182PH22"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006231-RA">
        <property type="protein sequence ID" value="AEPI006231-PA"/>
        <property type="gene ID" value="AEPI006231"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006231"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF75">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="3">
        <location>
            <begin position="195"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006231-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="610" mass="69228" checksum="7FDBF9ABE1491577" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI70</accession>
    <name>A0A182PI70_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PI70"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006632-RA">
        <property type="protein sequence ID" value="AEPI006632-PA"/>
        <property type="gene ID" value="AEPI006632"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006632"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006632-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10488" checksum="A01D50985C5063F2" modified="2016-09-07" version="1">MAYDLVAETGGVDLIGDRAALQQSADQQCTGREHFDHMKFLWFITFLLALVGMIAGDACPKGFKSQNNKCVTQRPVHGDCPKGSTYSAKVNLCVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI94</accession>
    <name>A0A182PI94_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SBNO family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PI94"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006656-RA">
        <property type="protein sequence ID" value="AEPI006656-PA"/>
        <property type="gene ID" value="AEPI006656"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006656"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000282">
        <property type="entry name" value="Strawberry notch homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057332">
        <property type="entry name" value="SBNO_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026937">
        <property type="entry name" value="SBNO_Helicase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026741">
        <property type="entry name" value="SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039187">
        <property type="entry name" value="SNO_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706:SF30">
        <property type="entry name" value="PROTEIN STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13872">
        <property type="entry name" value="AAA_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13871">
        <property type="entry name" value="Helicase_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25373">
        <property type="entry name" value="SBNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Strawberry notch AAA" evidence="7">
        <location>
            <begin position="271"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Strawberry notch helicase C" evidence="6">
        <location>
            <begin position="934"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="SBNO alpha/beta" evidence="8">
        <location>
            <begin position="1249"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="719"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="844"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006656-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1457" mass="159634" checksum="80302051FD715E88" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIL8</accession>
    <name>A0A182PIL8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIL8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006780-RA">
        <property type="protein sequence ID" value="AEPI006780-PA"/>
        <property type="gene ID" value="AEPI006780"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006780"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006780-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="157" mass="17716" checksum="BC20521003F8D61C" modified="2016-09-07" version="1">MLRHRQRKRNRAGLGVAGILLIAVGLVGKLCTANGATTVQYRQNVAPLARTTSTPAQLYFDAVAPEDRENFIKYHLDKALEERLPHHTSTVPKDFEFVSFQDALEPEHFSINLLDHFMIAYGLSERDVYEFVTLNVICFPSGWCFNPDDVGNVCCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIP4</accession>
    <name>A0A182PIP4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA-processing-splicing factor 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Splicing factor Prp8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PIP4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006806-RA">
        <property type="protein sequence ID" value="AEPI006806-PA"/>
        <property type="gene ID" value="AEPI006806"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006806"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000003">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="2153"/>
            <end position="2284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006806-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2386" mass="278914" checksum="FBA04823EC3DD4E3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJD8</accession>
    <name>A0A182PJD8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MRG-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJD8"/>
    <dbReference type="STRING" id="199890.A0A182PJD8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007052-RA">
        <property type="protein sequence ID" value="AEPI007052-PA"/>
        <property type="gene ID" value="AEPI007052"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007052"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007052-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24906" checksum="6D3959DEB3ACED58" modified="2016-09-07" version="1">MTTTVREKLEVEPNLEWTAEEEVQLFLAMEGVKPVGINRHFFMACIVERLSRALQREISSEAVWPHLRTLYNLKTLDEQEPVPFVNVECDFCLPEPDFCAVIAKRRQEESERAGAQASEHDSKKAETKLEPPAVKSSAAKTPISSSRQDPKDGDKEEKEGKDRGETGSSKLKPKNNDNVGGQDSGPKRSQKRTRGSLSTEPGHSNASSPANTPPNVPSSKRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJF7</accession>
    <name>A0A182PJF7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJF7"/>
    <dbReference type="STRING" id="199890.A0A182PJF7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007071-RA">
        <property type="protein sequence ID" value="AEPI007071-PA"/>
        <property type="gene ID" value="AEPI007071"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007071"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF103">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="86"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007071-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="282" mass="32035" checksum="2409BC271CFBC94D" modified="2016-09-07" version="1">ACFLILTELGLLPQVVKRGFYCNDQSIQHEYKGDTITTVTILLSGLVPMLLIWLTEALLYTPSISMSKTESESRSRGSWREAWYWSKKYGRGLITMLVIIGTIKIFLGELRPHFLSTCQPDVECQGTEYVSTYTCTNSEESLYFVRDASKSFPSGHSAMSVFEAIFLIWYLEKRVPRLRTLFTIPLLQMVLMCWAVFCSLSRITDNRHHWWDVLAGTIAGTIAAFMTCLFGCHNFDTSKRKRKTSLYTDHDHKLINSGSGNAATIGTPLHKEEINLNNVIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJN2</accession>
    <name>A0A182PJN2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A182PJN2"/>
    <dbReference type="STRING" id="199890.A0A182PJN2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007146-RA">
        <property type="protein sequence ID" value="AEPI007146-PA"/>
        <property type="gene ID" value="AEPI007146"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007146"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="14">
        <location>
            <begin position="73"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007146-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="651" mass="72829" checksum="50BC35702EFD25FE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJN7</accession>
    <name>A0A182PJN7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJN7"/>
    <dbReference type="STRING" id="199890.A0A182PJN7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007151-RA">
        <property type="protein sequence ID" value="AEPI007151-PA"/>
        <property type="gene ID" value="AEPI007151"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007151"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000009">
        <property type="entry name" value="ADAMTS-like protein 3 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF313">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131401" evidence="7">
        <location>
            <begin position="21"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="628"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="746"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="797"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007151-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1086" mass="119913" checksum="6AE49A378792E294" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJY9</accession>
    <name>A0A182PJY9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJY9"/>
    <dbReference type="STRING" id="199890.A0A182PJY9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007255-RA">
        <property type="protein sequence ID" value="AEPI007255-PA"/>
        <property type="gene ID" value="AEPI007255"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007255"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="135"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="223"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="267"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007255-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="352" mass="40029" checksum="F99D21AAEE3274EF" modified="2016-09-07" version="1">TEESVIFRDFTFTNWFNLFLCFPCFRSIAGAMSTFFTTNRHGYSVRFSPFNPDQFVVASSQFYGLAGGGTLYFLELTPDGCGIVEKRTHHWTDGLFDVTWSESNPEIIVSGSGDGSVQLWNTNLSSNNGPPSMVYREHKKEIYSVDWSKVPYEQLFISASWDSTVKIWDPIRNNSLSTYIGHTQLVYNAVFAAHIPNTFASVSGDGFLKIWDILCYDLPIASIKAHDGEVLTVDWCKHDSNILATGASDGLIRIWDLRNFGVPITELKGNEFAVRKVQFSPHNFSVLASVGYDFTTRIWDFKKSNEAIETIKHHSEFTYGLDWNRRRRNQLADCGWDSLVHVFKPDCLSEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKP7</accession>
    <name>A0A182PKP7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium-dependent multivitamin transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKP7"/>
    <dbReference type="STRING" id="199890.A0A182PKP7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007514-RA">
        <property type="protein sequence ID" value="AEPI007514-PA"/>
        <property type="gene ID" value="AEPI007514"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007514"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007514-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="65176" checksum="570EC279DECF3D8C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKZ5</accession>
    <name>A0A182PKZ5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Diacylglycerol lipase-alpha</fullName>
            <ecNumber evidence="21">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Neural stem cell-derived dendrite regulator</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Sn1-specific diacylglycerol lipase alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="36 37">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="36">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38511"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38512"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38515"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75449"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:38516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = 2-(9Z,12Z-octadecadienoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38523"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75450"/>
            <dbReference type="ChEBI" id="CHEBI:75457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:38524"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O = 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38527"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75913"/>
            <dbReference type="ChEBI" id="CHEBI:75914"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:38528"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = 2-octadecanoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38519"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75448"/>
            <dbReference type="ChEBI" id="CHEBI:75456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:38520"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:38508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="29">Interacts (via C-terminal) with CAMK2A; leading to the phosphorylation and inhibition of DAGLA enzymatic activity. Interacts (via PPXXF motif) with HOMER1 and HOMER2; this interaction is required for DAGLA membrane localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Postsynaptic density membrane</location>
            <topology evidence="22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="21"/>
    <dbReference type="AlphaFoldDB" id="A0A182PKZ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007612-RA">
        <property type="protein sequence ID" value="AEPI007612-PA"/>
        <property type="gene ID" value="AEPI007612"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007612"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032591">
        <property type="term" value="C:dendritic spine membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004465">
        <property type="term" value="F:lipoprotein lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098921">
        <property type="term" value="P:retrograde trans-synaptic signaling by endocannabinoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000015">
        <property type="entry name" value="Sn1-specific diacylglycerol lipase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 34" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 34" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 34" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="35">
        <location>
            <begin position="398"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="1005"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="1077"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="1199"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="33">
        <location>
            <begin position="1005"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="1212"/>
            <end position="1242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00037872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00050486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00050709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00050861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00052106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00052463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00063298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00071957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00081678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00082132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007612-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1242" mass="136775" checksum="64065AE476DE1D43" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLA9</accession>
    <name>A0A182PLA9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0488 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLA9"/>
    <dbReference type="STRING" id="199890.A0A182PLA9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007726-RA">
        <property type="protein sequence ID" value="AEPI007726-PA"/>
        <property type="gene ID" value="AEPI007726"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007726"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029274">
        <property type="entry name" value="DUF4615"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13602">
        <property type="entry name" value="UPF0488 PROTEIN C8ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13602:SF2">
        <property type="entry name" value="UPF0488 PROTEIN C8ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15393">
        <property type="entry name" value="DUF4615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007726-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="214" mass="23685" checksum="7E801F588B7DCAE9" modified="2016-09-07" version="1">MAPPKVKLHKNTGKLKYSPRPGSLASPAPPPSTTPATGNAPSAEQSEADRQFELELYWCIQQLESQLSLPNVRENNKKLEETSKLINTLKSGTQPIIRKRQIMRTTFGDYRSKMAEEEQTMALNPDSVRFEGPKEKAKYHFVKKSAILAGDKNFKFNFPKVVNDTEAVPAVVPVESEAPEDLEPVKTVPVSQATVGKIVPSDNSFRFNFAVGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLU9</accession>
    <name>A0A182PLU9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLU9"/>
    <dbReference type="STRING" id="199890.A0A182PLU9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007921-RA">
        <property type="protein sequence ID" value="AEPI007921-PA"/>
        <property type="gene ID" value="AEPI007921"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007921"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000006">
        <property type="entry name" value="Cytochrome P450 302a1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007921-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="545" mass="62550" checksum="E5241465BF71CB11" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMG7</accession>
    <name>A0A182PMG7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMG7"/>
    <dbReference type="STRING" id="199890.A0A182PMG7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008140-RA">
        <property type="protein sequence ID" value="AEPI008140-PA"/>
        <property type="gene ID" value="AEPI008140"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008140"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000002">
        <property type="entry name" value="Gata transcription factor gatad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF337">
        <property type="entry name" value="GATA-BINDING FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="563"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="510"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008140-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="730" mass="79043" checksum="8998014B5BCC5DCE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMJ3</accession>
    <name>A0A182PMJ3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fibulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PMJ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008167-RA">
        <property type="protein sequence ID" value="AEPI008167-PA"/>
        <property type="gene ID" value="AEPI008167"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008167"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
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    <keyword evidence="8" id="KW-0732">Signal</keyword>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1697" mass="186518" checksum="6DAA4C3688667017" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN44</accession>
    <name>A0A182PN44_9DIPT</name>
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        <recommendedName>
            <fullName evidence="8">Regulator of G-protein signaling 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN60</accession>
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            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="12">Epiroticus2</strain>
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</entry>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PNA0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008425-RA">
        <property type="protein sequence ID" value="AEPI008425-PA"/>
        <property type="gene ID" value="AEPI008425"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008425"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000240">
        <property type="entry name" value="AGAP005458-PA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000004">
        <property type="entry name" value="UDP-sugar hydrolase, putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF32">
        <property type="entry name" value="APYRASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131640" description="5'-Nucleotidase C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="9">
        <location>
            <begin position="337"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="9">
        <location>
            <begin position="1136"/>
            <end position="1301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008425-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1340" mass="148642" checksum="665FE52D1748B55D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNG0</accession>
    <name>A0A182PNG0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNG0"/>
    <dbReference type="STRING" id="199890.A0A182PNG0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008487-RA">
        <property type="protein sequence ID" value="AEPI008487-PA"/>
        <property type="gene ID" value="AEPI008487"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008487"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF325">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="167"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="328"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008487-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="537" mass="58919" checksum="E094AAFE959130E8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNJ2</accession>
    <name>A0A182PNJ2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger CCHC-type and RNA-binding motif-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNJ2"/>
    <dbReference type="STRING" id="199890.A0A182PNJ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008519-RA">
        <property type="protein sequence ID" value="AEPI008519-PA"/>
        <property type="gene ID" value="AEPI008519"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008519"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044598">
        <property type="entry name" value="ZCRB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46259">
        <property type="entry name" value="ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46259:SF1">
        <property type="entry name" value="ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008519-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22210" checksum="9C2A0C70F1C28671" modified="2016-09-07" version="1">MNKPKLLVPDIRCTAYISNLPYDLTNIDVHKLFSKHGKIIKVTILRDKVSRKSKGVAFVLFSNAQEALDCCNACNSTEMFGRTVKASIAKDNGKSAEHAHRKQYPDKSRCYECGVEGHMSYSCPKNVLGSKSPPRKERRKIVKRKHPTESTESTAWASDAEEEPVTASADSTTTVGTKKVKYRKSNYFSDDEELDTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNU7</accession>
    <name>A0A182PNU7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNU7"/>
    <dbReference type="STRING" id="199890.A0A182PNU7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008626-RA">
        <property type="protein sequence ID" value="AEPI008626-PA"/>
        <property type="gene ID" value="AEPI008626"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008626"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="3"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008626-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="210" mass="22418" checksum="453360DAB2C210BF" modified="2016-09-07" version="1">HSIVGGHASLPGAAPYIVAVKTTADSTFLCAGVLLKSTWILTTAQCVQDKIATDLQVLLGSHRLLTNKATISVTKIERHPSYNTVSSANNLALLQLSNSVPLSTRVNTIALNDAPIASNVPVVFYGWGSTSYGAIAYSNVLQTLYKRTLSTVDCRTRNNLMALSDDNICTIDQQGQAACSRDEGGPLVQYDTPKLIGLFNYGSQCNGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPN5</accession>
    <name>A0A182PPN5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPN5"/>
    <dbReference type="STRING" id="199890.A0A182PPN5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008914-RA">
        <property type="protein sequence ID" value="AEPI008914-PA"/>
        <property type="gene ID" value="AEPI008914"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008914"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF30">
        <property type="entry name" value="MEMBRANE FRIZZLED-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="474"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008914-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="589" mass="65180" checksum="2AA6ACE521308736" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPV8</accession>
    <name>A0A182PPV8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF2428 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PPV8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008988-RA">
        <property type="protein sequence ID" value="AEPI008988-PA"/>
        <property type="gene ID" value="AEPI008988"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008988"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF7">
        <property type="entry name" value="THYROID ADENOMA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="3">
        <location>
            <begin position="563"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="2">
        <location>
            <begin position="887"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="4">
        <location>
            <begin position="1190"/>
            <end position="1351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008988-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1618" mass="183973" checksum="B41E24A30A8F728A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPZ4</accession>
    <name>A0A182PPZ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartate aminotransferase</fullName>
            <ecNumber evidence="13">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70223"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:70225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70295"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="ChEBI" id="CHEBI:140699"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:70297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:21825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteine + 2-oxoglutarate = 2-oxo-3-sulfanylpropanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17441"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57678"/>
            <dbReference type="EC" id="2.6.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17442"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A182PPZ4"/>
    <dbReference type="STRING" id="199890.A0A182PPZ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009024-RA">
        <property type="protein sequence ID" value="AEPI009024-PA"/>
        <property type="gene ID" value="AEPI009024"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009024"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120554">
        <property type="term" value="F:2-aminobutanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047801">
        <property type="term" value="F:L-cysteine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000044">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="14">
        <location>
            <begin position="30"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009024-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="405" mass="45020" checksum="53B32DA1C2BE9ADC" modified="2016-09-07" version="1">MSSIFASVELGPPVEVFALNKACLEDPNPNKVNLGVGAYRTNEGKPWILPVVKKAETAIVADGSLNHEYLPVLGMDSITNAASTLLLGEDSDALKSKRAFGVQCLSGTGALRLGAEFLARILNRTIFYYSNPTWENHHKVFLYAGFTEPRTYRYWHQESRAIDFAGMLEDLGNAPEGAVVILHACAHNPTGIDPTEDQWKQIADVCEKRKLFPFFDSAYQGFASGDPNKDAFAVRYFVSRGFELFCAQSFAKNFGLYNERIGNLTVVQKEASTSAAVASQITLLVRGMYSNPPAFGSRIVSRVLNDPELRNEWMECIKTMSSRIITMRKALYDELVALKTPGTWEHITNQIGMFSYTGLNEKQVQILIKEFSIYLLKTGRISMCGLNENNVAYVARAIHAAVTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQK0</accession>
    <name>A0A182PQK0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 13"/>
    <dbReference type="AlphaFoldDB" id="A0A182PQK0"/>
    <dbReference type="STRING" id="199890.A0A182PQK0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009231-RA">
        <property type="protein sequence ID" value="AEPI009231-PA"/>
        <property type="gene ID" value="AEPI009231"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009231"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000045">
        <property type="entry name" value="Disulfide-isomerase A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000077">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000303">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007951000" description="Protein disulfide-isomerase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="343"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="393"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009231-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="488" mass="54462" checksum="C6B8761859E53F33" modified="2016-09-07" version="1">MSCRLLLVCLCALVVVAYAGEADVLDLTDSDFSTRVGETETTLVMFYAPWCGHCKKLKPEYAKAAELLRGEDPPIALAKVDCTEGGKDTCNKFSVSGYPTLKVFKNGEVSQEYNGPREANGIAKYMKSIVGPASKDLLTVEAFEAFLKVQETSVVGFFQKESDLKGVFLKYADSQRERLRFGHSSAPAVLEKQGETDAVYLFRARQLANKFEPDFVKFEGTTKQELADFVKANYHGLAGVRSRDTTSDFKNPLVVVYYAVDYVKNPKGTNYWRNRVLKVAKEFVGRINFAVSAKDDFQHELNEYGYDYTGDKPLVLARDAKNQKFIMKDEFSVENLQAFATELEEGSLEPYVKSEPVPESNDGPVKVAVAKNFDEVVVNNGVDTLVEFYAPWCGHCKKLAPTLEELGTKLKDEAVSIVKMDATANDVPSHFEVRGFPTLYWLPKDSKTSPTRYEGGREVDDFVKYIAKHATSELKGFDRSGSAKKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRB9</accession>
    <name>A0A182PRB9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRB9"/>
    <dbReference type="STRING" id="199890.A0A182PRB9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009503-RA">
        <property type="protein sequence ID" value="AEPI009503-PA"/>
        <property type="gene ID" value="AEPI009503"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009503"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="72"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="364"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009503-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="534" mass="59096" checksum="EC1C2493BE93EBE2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRD6</accession>
    <name>A0A182PRD6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRD6"/>
    <dbReference type="STRING" id="199890.A0A182PRD6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009520-RA">
        <property type="protein sequence ID" value="AEPI009520-PA"/>
        <property type="gene ID" value="AEPI009520"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009520"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF166">
        <property type="entry name" value="LD40136P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="108"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009520-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="327" mass="37389" checksum="8D970E3537A20866" modified="2016-09-07" version="1">MDIDTTVYSNCTSPATYQQYTWALTDKLRKTAKSELREDEHLRSQGLAQMREFIAKSPHIKRCRTDALFLLRFLRAKKYSIPQACAMLEKYLTVRQTNPSWFQRLDIDDPEIAAIIDGGYIVPLPERDDHGRQVILSVAGNLDLNRVSSALLARVHFMVQEVLADDEQSQICGYVHCVDERELTMKLMGMWSLVDIKKVVDCIQNGVPSRINGFNLIGMPSTAATLLEFCVSLLNDKLRKRINLYRTVEDFAGKINRKIIPKEYGGTVPMANMIAQFKERCRRKRAQLLAMDEMYIELSKMPGHCADSCRRDLEAGMIGSFRKLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRN4</accession>
    <name>A0A182PRN4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chemosensory protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRN4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009619-RA">
        <property type="protein sequence ID" value="AEPI009619-PA"/>
        <property type="gene ID" value="AEPI009619"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009619"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF11">
        <property type="entry name" value="CHEMOSENSORY PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131859" description="Chemosensory protein 1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009619-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13886" checksum="A81A2E9D3DDD2054" modified="2016-09-07" version="1">MQKTTSKVSSRSAVSICWLAIGLCLVWMVAVSAESTATTARTQVSDEALEKALSDKRYLMRQLKCALGEVPCDPVGKRLKSLAPFVLRGACPQCTPVEMNQIKKTLAHLQRNFPSEWNKLVQTYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRP0</accession>
    <name>A0A182PRP0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Solute carrier family 25 member 40</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRP0"/>
    <dbReference type="STRING" id="199890.A0A182PRP0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009625-RA">
        <property type="protein sequence ID" value="AEPI009625-PA"/>
        <property type="gene ID" value="AEPI009625"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009625"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="161"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="251"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009625-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="43854" checksum="FFEC8D4CB9EFC45F" modified="2016-09-07" version="1">MARSVGSSIVAVAPGQDMDDSRFRIRPYQQILSSCSGALVTSLFMTPLDVVKTRLQAQQKVLISNKCYLYCNGLMDHICPCGPNGPLGPTAISKRPLHFTGTIDAFTKISRYEGVPSLWSGLGPTLILALPTTVIYFVAYEQFRIQLKELYQRRKGRDAELPIWLPLLAGSSARVLAVTIVNPLELIRTKMQSEKLSYREVGQAFRSMLRVQGIFGLWKGFFPTILRDVPFSGIYWTTYESYKKHFNVSQPTFAFSFAGGAISGGVAAFFTVPFDVVKTHQQIAFGEQFLYAQNGNGAVDGKKRAFKAIGTFETMGRIFQMNGIRGLFAGLTPRLVKVAPACAIMIASFEYGKNFFYRYNVQRYQEKKASGDSSLVSSLVPPLHSLAPRRAADVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRW2</accession>
    <name>A0A182PRW2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidoglycan-recognition protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRW2"/>
    <dbReference type="STRING" id="199890.A0A182PRW2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009697-RA">
        <property type="protein sequence ID" value="AEPI009697-PA"/>
        <property type="gene ID" value="AEPI009697"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009697"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017331">
        <property type="entry name" value="Peptidoglycan_recognition"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF77">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037945">
        <property type="entry name" value="PGRPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0391">Immunity</keyword>
    <keyword evidence="2 6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="9">
        <location>
            <begin position="31"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="8">
        <location>
            <begin position="42"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="68"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009697-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="205" mass="23116" checksum="23E2FFA076706AD5" modified="2016-09-07" version="1">MELVKDFCLYFGAMAFTLMSIAFDSKACDPVPYVTRDVWNALPPKQIERFSGPIPFVIIHHSYQPAACYNGLQCIAAMQSMQRMHQNVRQWNDIGYSFAVGGDGRVYQGRGFNVIGAHAPRYNNRSVGICLIGDWVAELPPKNMLAAAQNLIEYGVRNGLIAQNYTLLGHRQVRTTECPGDRLFEEIKTWPHFNPMTDIVDQNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS99</accession>
    <name>A0A182PS99_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="13">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54232"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:76979"/>
            <dbReference type="ChEBI" id="CHEBI:78228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:54233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:74963"/>
            <dbReference type="ChEBI" id="CHEBI:82949"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:54333"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:54245"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:32940"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A182PS99"/>
    <dbReference type="STRING" id="199890.A0A182PS99"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009834-RA">
        <property type="protein sequence ID" value="AEPI009834-PA"/>
        <property type="gene ID" value="AEPI009834"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009834"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000002">
        <property type="entry name" value="Choline/ethanolamine phosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
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    </dbReference>
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    </dbReference>
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            <end position="71"/>
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            <end position="164"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="215"/>
            <end position="234"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
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            <begin position="466"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
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            <begin position="477"/>
            <end position="489"/>
        </location>
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            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
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        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
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        <location>
            <begin position="539"/>
            <end position="581"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036890"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009834-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="587" mass="65847" checksum="BA6F66FEA9AAA2DF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSK2</accession>
    <name>A0A182PSK2_9DIPT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PSK2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009937-RA">
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        <property type="gene ID" value="AEPI009937"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009937-PA"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="728" mass="83409" checksum="14855EAEB63106E4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVB0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
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        <property type="gene ID" value="AEPI010897"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI010897"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1230"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010897-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1459" mass="163775" checksum="E5A3628FA15D57FF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVJ5</accession>
    <name>A0A182PVJ5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Howell P."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVJ5"/>
    <dbReference type="STRING" id="199890.A0A182PVJ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010982-RA">
        <property type="protein sequence ID" value="AEPI010982-PA"/>
        <property type="gene ID" value="AEPI010982"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010982"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010982-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="44326" checksum="0BBAC305E1E9860B" modified="2016-09-07" version="1">NDDLKASLERFWDVEELLPCIPNTTSLLDQDLEEHFKRHTKIADDGRFIVRIPLWGELNQLGDSMEQAQRRLLSLERRLARHKHTYEDYRKFIREYLELRHMTPVLPHELNKVRYVILHLCVVKPDSTTTMLRVVFDASAKSTTGVSLNDLQAIGPVIQPDLLHVWLHFRMQTVVVTADIAKMYRQVWVAEPDTWMQCILWRDDTTCSAQMYRLCSVTYGEASSSYLVCRVLYEVGEEIRSSIQEIADAIQRSFYVDNLSMGAATKAIKMLGLAWCPTADTFQLIIEDAFHTPVNTLTKRGLVSRITKLYDPVGILQPVIITAKIIMQDLWRDNLKLYERIKDVFGARIRQTRWWTDSQVVLAWIRSDNTKSSSQDSSSDEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVW4</accession>
    <name>A0A182PVW4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVW4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011101-RA">
        <property type="protein sequence ID" value="AEPI011101-PA"/>
        <property type="gene ID" value="AEPI011101"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011101"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898">
        <property type="entry name" value="DAEDALUS ON 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898:SF1">
        <property type="entry name" value="MD-2-RELATED LIPID-RECOGNITION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00697">
        <property type="entry name" value="DM8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011101-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="444" mass="52073" checksum="7586713A4DC679D2" modified="2016-09-07" version="1">MGRHPTNVTYLAYLEAMREIRDIKTYFTYSVRLFNGTIQNPILSRWVDPCELVRRPPVDRIIRMYYDPIIKNSRIKRCPFKRGESMLLNITPSILPIPKFIPETDFYLEAKTYTRMRTKVIFESRVFGSLIIPVLSKMDCKFNKRIINMTCTLDQSSSITNQSVSMDMLVIREVKDVKLTFEYHVLSESSDTTNRIFQRTVDFCSYIKRPSSDRLMKVVFDHMKRNSRFISKCPVAKNEKLYLHDIRPAAIRIPGFLPESSFVFKTIYQTAVLLVPIVDVRYHGKLVRFENSELEDQLNTITNQSISFELKVLREVKELKLVAAYYVVSGDSMNRLVQRTVDFCSYVKRPNNDRLVKVFFDHVKHNSRFISKCPVAKDECFYIHGIRPADIRIPGFIPESSFIFDNNYHSGTLLEPIAEIRYYGKFIRFMNKDLERSQPKGSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWD0</accession>
    <name>A0A182PWD0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWD0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011267-RA">
        <property type="protein sequence ID" value="AEPI011267-PA"/>
        <property type="gene ID" value="AEPI011267"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011267"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026703">
        <property type="entry name" value="ERICH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21520">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21520:SF2">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011267-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="359" mass="37643" checksum="E50D7951AE2F3D0E" modified="2016-09-07" version="1">MSDFCANMALLDDTNGNTVNINNQPAGEGAGDGCNVDGCGMVPTTGESVAMLHSLSNDDLSQSLSEYTDADESISAPTELLAEFLSAIMIRDYVNALKYCKQILHYEPNNTTARDFYPHILSKISEMQSNELSGESDENYNINCSSPLPSFGSTPSSCSVSSSPASTRSSRSSRSSHSSFGSSSSGCDDNIDEVIMVCSSDSDESSEACCSLADSDGEKLATGGPPKVTEDNSSLQVDCDGETNGLVVPVPVAAVGNSRSLSDNNTSQSYSSLLLEDEEKDLTLSDISNLNIEEDETSNDCGGSLENSYSPVDVTTSTAPVVIPPVLNTNLASASVFASRLVAMLRSKVIPSKTVGSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWD4</accession>
    <name>A0A182PWD4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWD4"/>
    <dbReference type="STRING" id="199890.A0A182PWD4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011271-RA">
        <property type="protein sequence ID" value="AEPI011271-PA"/>
        <property type="gene ID" value="AEPI011271"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011271"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002257">
        <property type="entry name" value="CLUMA_CG019509, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF2">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 19, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="108"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011271-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="214" mass="24168" checksum="61C221C024C67E21" modified="2016-09-07" version="1">SNVAKAAHRNSLGPLQSQFITKNNTRVISQRGGLAVLPCSVTMTTPATVSWFRRKDYQLLTVGLSTYSSDDRFLVEHTRHLGNWALRIKNARKEDEGLYECQISTHPPQSIFMELRIVEAAAEILGLSNMHIDEGSTLRLECKLKRATESPLYVFWYLEDRMVNYDQEDGVSVWNNKLNSSILTVRNVTARHGGNYTCAPANARQASVYVHVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX24</accession>
    <name>A0A182PX24_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX24"/>
    <dbReference type="STRING" id="199890.A0A182PX24"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011511-RA">
        <property type="protein sequence ID" value="AEPI011511-PA"/>
        <property type="gene ID" value="AEPI011511"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011511"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011511-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="344" mass="38707" checksum="A180C9F87111A2C3" modified="2016-09-07" version="1">GDRVELVSLSDGEGVLKTLGLYWCPKQDEFAFIVNNLQEPPNPPTKRTVLSEISKLFDPIGLLSPVIVIAKLIMQKIWVAGLPWDTQLEGDILQEWLQFRTSLQHVNNIRISRCLLYPNHIKVELHGFSDASKHAYGAALYLRCVYADASVSLRLICSKSRVAPVKPITIPRMELLGAHLLARLISKVAGSFNLQFSNIILWTDSQIVLAWLTKPSSALHVFVRNRVANIRLFLEPLKVQWKYISTKENPSDVVSRAERAVLEAMEQRIYSEFAATHQESTSSSQHSPRNDRVGRRERPAFVDLEVGHHRQHLPEIGHLSSSSGCQNRGEHLSASSFPPVHPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX62</accession>
    <name>A0A182PX62_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX62"/>
    <dbReference type="STRING" id="199890.A0A182PX62"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011549-RA">
        <property type="protein sequence ID" value="AEPI011549-PA"/>
        <property type="gene ID" value="AEPI011549"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011549"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011549-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="229" mass="25837" checksum="70B5083C0374FA52" modified="2016-09-07" version="1">MMNRVYLSGTFPAIWNDCIVVPVHKKGDRMDPSNYRGIVLISCVLKVLTKVLANRLQSVAQKLGLYILVMMNRVYLSGTFPAIWNDCIVVPVHKKGDRMDPSNYRGIVLISCVLKVLTKVLANRLQSVAQKVIRKEQTGFMRAEECTAQAACLLEACQRRKFRGEKTLLCFLDLKKAYDLVPHKRLLSKLRAIGLGATMVRFIAAMYNNTSIRVRIGSSIGEPMNYKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PXC6</accession>
    <name>A0A182PXC6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Suppressor of cytokine signaling 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PXC6"/>
    <dbReference type="STRING" id="199890.A0A182PXC6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014018-RA">
        <property type="protein sequence ID" value="AEPI014018-PA"/>
        <property type="gene ID" value="AEPI014018"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014018"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09923">
        <property type="entry name" value="SH2_SOCS_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03717">
        <property type="entry name" value="SOCS_SOCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000111">
        <property type="entry name" value="Suppressor of cytokine signaling, invertebrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF32">
        <property type="entry name" value="LP02169P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="244"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="8">
        <location>
            <begin position="346"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014018-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44825" checksum="51625B246C44A2B2" modified="2016-09-07" version="1">MTMEETDRISGAVGACEQSSHERSSTNRISKAATAPRTSSADGTCRFNWFLSLRRKRSSSTTVVVATAHSKKNDGARSVKEELFTTSDENNPANQTEGGSVFYTLRKRFQKKFTSVKVKAFEPNVADTLGNVIAPNAATVNTNNNDSIHCNGTTRERLPADMCTTGNDFARIVIERHTQNPIRFSSPNANLPVIINSRDTEPITADDSRPLSTVPLPVDTTEPSTADMDDMMAQMRIDLLQYGWYWGKLTRLAAQKRLAQQVNGTFLVRDSQTEKHQFTVSFRSSGITLHCRIDFENNYWSFSGLTTPTTYKTMVDLIQDTMKKSEFGVIGYVKQDTTLMPPFPVRLTRPINRFYEVSSLQHLCRFIIRQKIDAKSINELPLPEKLKKYVEENFYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PKB5</accession>
    <name>A0A240PKB5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A240PKB5"/>
    <dbReference type="STRING" id="199890.A0A240PKB5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015382-RA">
        <property type="protein sequence ID" value="AEPI015382-PA"/>
        <property type="gene ID" value="AEPI015382"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015382"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015382-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="371" mass="40869" checksum="EEFFBA9600F81322" modified="2017-10-25" version="1">MPDNEIVMFDNITRTIESSFSSESTERISAEQWIKVDNETLASLSSTTAMVDSSTVTSSTSSSTSSSSSEIPNSSSTARSTTTTEAGGQMMPNATYAESYHEYLPNNTEMSMVLTKGHSRTASNESMYELVTTTSRVEITFIDTAVKKIEDPFTINSTALEEEPSSLATDSSNETDTQLVYLESENQPVLVDFSGDGTVQHEANDRQAFVTISCLLITLTLLTSVVVYMKRLNRKTLAKPAASAPPPVKIVDESVQTGNDPSNRSSEPLPDLPHVTYTRVKPKLQRNGDIEHYDVPPNNSFIHRAKSSPYNYNFSVNQKQAPRKYSLEHIYDEIQYPPLAEITASTAQPDKPTVQLQGEKDDSYSKPMVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PM32</accession>
    <name>A0A240PM32_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PM32"/>
    <dbReference type="SMR" id="A0A240PM32"/>
    <dbReference type="STRING" id="199890.A0A240PM32"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015330-RA">
        <property type="protein sequence ID" value="AEPI015330-PA"/>
        <property type="gene ID" value="AEPI015330"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015330"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000003">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_A">
        <property type="entry name" value="Ribosomal_uL22_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057265">
        <property type="entry name" value="Ribosomal_uL22_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003260">
        <property type="entry name" value="PRK04223.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015330-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="187" mass="21678" checksum="907D8F511C840179" modified="2017-10-25" version="1">MGRYAKEPDNASKSCKSRGSNLRVHFKNTRETALAIKRMPLRRAQRFLKNVIEKKECVPFRRFNGGVGRCAQAKHWGTSVGRWPKKSAEFLLQLLKNAEANADYKGLDVDRLVINHIQVNRAPCLRRRTYRAHGRINPYMSSPCHIELSLTEKEDVVTKATDESEQAKKKLSKKKLQRQKEKMMRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P057</accession>
    <name>A0A182P057_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P057"/>
    <dbReference type="STRING" id="199890.A0A182P057"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000289-RA">
        <property type="protein sequence ID" value="AEPI000289-PA"/>
        <property type="gene ID" value="AEPI000289"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000289"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130586" evidence="4">
        <location>
            <begin position="30"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000289-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="171" mass="18746" checksum="4A374A50598510F7" modified="2016-09-07" version="1">MQQRSSAIASFGKLLVVALFALQATIPEATVEGCSMMNNDNAEQRGALLADPATAKQMPEVTMQDAVAQCNRSFIIQPEYLAELNQTGSFPDETDKIPLCFIRCYLKTLGILTEDDKVNKEVALGLNWATSGETVDECLDEMTGSACEQAYFFTRCIMTRALVDGKSKDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0E8</accession>
    <name>A0A182P0E8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="17">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="17"/>
    <dbReference type="STRING" id="199890.A0A182P0E8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000380-RA">
        <property type="protein sequence ID" value="AEPI000380-PA"/>
        <property type="gene ID" value="AEPI000380"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000380"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 17" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="14 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="20">
        <location>
            <begin position="235"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1497"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="931"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1526"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1538"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1551"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1564"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1624"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1711"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1770"/>
            <end position="1877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000380-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1877" mass="207871" checksum="DBD30CF122038199" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0K5</accession>
    <name>A0A182P0K5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PP1c_bdg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0K5"/>
    <dbReference type="STRING" id="199890.A0A182P0K5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000437-RA">
        <property type="protein sequence ID" value="AEPI000437-PA"/>
        <property type="gene ID" value="AEPI000437"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000437"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051254">
        <property type="entry name" value="PPP1R15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16489">
        <property type="entry name" value="GH11727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16489:SF12">
        <property type="entry name" value="GH11727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000437-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="511" mass="57379" checksum="B739D6FD23AE6A76" modified="2016-09-07" version="1">MLSERKQCCYQPMAMDNNDFPMREVEYGEWSNQRPTQHSYPIADGNEKLADLKMGDDKPPVITACTAQKRPSIVDNVFNMINNIFNFASRNGTKPDMDSSVSLTEKEEKPKEASCTTSPCIPIFETTKSGKNQLTVPLDYSSTVDDISMTPAGVYVEEMARCERNAQRPGRRKRRKDASRSNQHQQHTGAEGKGGSKNRKEKKRHALRMDIWNDNLALSLDDSTYGYDFRDALCSNTMETHSLPQRCLSSSFSPSPSGSIGSFHDALSDILPAESMHLRTSSAGTRAAVSAAICGSQPSSQASFSATPGSVDTIVEQSNSRVKCDIVEPTKPVEFVVFTDYDVLTTPSASPARRRPPPRNLCQAFSYVWRHKHPDDSQEESDSEEEDDSTSVDNTDEEGGLLDDDDDDDSIVFCEDYDDLNDDSNSSSGFEEKKVRFNSKPVVHVMRAWDFAYRQARKGDWETAARDRERFRKRIADLEPVLGAVLQPTLRDKIYSERFNEEKESNTRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0M0</accession>
    <name>A0A182P0M0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0M0"/>
    <dbReference type="STRING" id="199890.A0A182P0M0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000452-RA">
        <property type="protein sequence ID" value="AEPI000452-PA"/>
        <property type="gene ID" value="AEPI000452"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000452"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19744">
        <property type="entry name" value="bHLH_TS_dAS-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935:SF106">
        <property type="entry name" value="ACHAETE-SCUTE COMPLEX PROTEIN T5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="84"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000452-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="396" mass="43307" checksum="F6B7E8173A988DAD" modified="2016-09-07" version="1">MSSLNPLKRLKLKENQMVTVAVRGDYPTGPLKRKLPLGNYVSADNVLPVLPLQTLQAKQFGDVTSLPASGRKRPGSGEPRNVVSAVERRNARERNRVQQVNNGFAALRQRIPDEIAEAFEAGTTPRGVHKKLSKVETLRMAVEYIKSLERLLEQSGTGRVPATFSGHDDDPPEAQLPATPPPEPTGQSGSNFFLAIKPIRPAKTAAPGNIGGGVGSAGATGSTNGTETQITIINGHQYMRIPGTNTFQYLDPQRLHGAYEDLLEAEEEGGEEQQPIPTLPEEDGEEDTCSSGGDLLSESAIALSPQSNFTLEPDTDSKRDVDSLYQSIVSQPDGGMFDQQQYDDLMLIKSELQDEADLTEDASFLSWFEANQQLQLQQQLQQHLQQQLHSQQTLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0S5</accession>
    <name>A0A182P0S5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182P0S5"/>
    <dbReference type="STRING" id="199890.A0A182P0S5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000507-RA">
        <property type="protein sequence ID" value="AEPI000507-PA"/>
        <property type="gene ID" value="AEPI000507"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000507"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24660">
        <property type="entry name" value="PGAP1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="705"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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        </source>
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        </source>
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    <sequence length="989" mass="111231" checksum="3E30D749D7ED5D97" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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    <name>A0A182P0T2_9DIPT</name>
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        </submittedName>
    </protein>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <strain evidence="2">Epiroticus2</strain>
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</entry>
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            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
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            <taxon>Nematocera</taxon>
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                <person name="Howell P."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Epiroticus2</strain>
        </source>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        </source>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="143" mass="16041" checksum="F503A1C169811C50" modified="2016-09-07" version="1">MVKEQRSSGGSVNYLQLFSSFSLVTTLFDFCEDCSSMACLPQSAFAVHKIRQAQNEKDLTVARLTGDKQVPRYLNKSTLDLTPVKYNGKLMNSIWGLYNRYSPHNFKKNNGSFGGFFGMQQPFAVACSPMEKELPVPNPAEQK</sequence>
</entry>
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    <accession>A0A182P105</accession>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Howell P."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
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        </subcellularLocation>
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        <property type="gene ID" value="AEPI000587"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Kalirin RhoGEF kinase b"/>
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        <property type="entry name" value="Spectrin/alpha-actinin"/>
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        <property type="entry name" value="Spectrin_repeat"/>
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        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23323">
        <property type="entry name" value="Spectrin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="1266"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="1459"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1140"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1197"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1595"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="510"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="596"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1145"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1608"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1627"/>
            <end position="1637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000587-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1637" mass="186468" checksum="93F1A4EEA46911B3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P136</accession>
    <name>A0A182P136_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P136"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000618-RA">
        <property type="protein sequence ID" value="AEPI000618-PA"/>
        <property type="gene ID" value="AEPI000618"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000618"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032055">
        <property type="entry name" value="TMEM72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28474">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28474:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16054">
        <property type="entry name" value="TMEM72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000618-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="143" mass="15911" checksum="A99B2567AE6727E7" modified="2016-09-07" version="1">MAVLTIPMPAHNDYSSSCYQCWSVCRYCGGWHLTFPYVALGIALIVWPHRLWLSHVAGGLLIALAMLRLLTVCKFRPHGKDDELLNHFDEHADKYDNLSDVLVDNSMPEPGHGLEGSNGSNHGVHHDDNEDDDDDVTINGDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1E0</accession>
    <name>A0A182P1E0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RPA43 OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1E0"/>
    <dbReference type="STRING" id="199890.A0A182P1E0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000722-RA">
        <property type="protein sequence ID" value="AEPI000722-PA"/>
        <property type="gene ID" value="AEPI000722"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000722"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000722-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44494" checksum="2E7AB14FC3B5018F" modified="2016-09-07" version="1">MHRTTIAKYTKFSAEELQKSIADPLSCVVLVQLNEILSLRPRDCEHIVKGVRRCVTDKIGRYHAKVNGIVLGYAKIRIDNALSALRLDSPYLHVRATIDYYVFQPRIGSTLRGTVNYVSKEFVSAVIYRVFNVTVKLGKNANRQHTIVKGSDISFTVRSCDMKSELPVIEGELVLNGVIPVNIKKEPGVENDDSVDCPPMEEQKQQNGVEEEMETEETNVSVVVKKEPKTSKQKKSEQKKKQKKPVVASPVSNGLLAGGEASSSSESEDDERSLLIKSLIDQMFGDEFKKSTKKSSKKSKKKDKKKSPKKSLDLSETPIRIKQEKLSTDEDEPTSSVQSKPSKSPGESKQNGTNGYRANGSGVAASSTPIVATTDGQTAGSSGKKRKIRFDLNHTTVRCFDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1R1</accession>
    <name>A0A182P1R1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1R1"/>
    <dbReference type="STRING" id="199890.A0A182P1R1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000845-RA">
        <property type="protein sequence ID" value="AEPI000845-PA"/>
        <property type="gene ID" value="AEPI000845"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000845"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000845-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="324" mass="31457" checksum="EC9B647B0D947F04" modified="2016-09-07" version="1">MYRVNIVSANPSVSASSSSSSSNSSSSSSGTSVASIVGSAGNVILQQAPQILGIAGGSTILAGQAGTTTALPIGTIVSIQQSQPQAQSQQPIAASASTATATIIGLSASTLSALNAATAVGAGGGATIASGGATITPVAAGSGGAGGATVVANQLLKVAAGNNNSISILKIGDDIMLKAVKVEPLPSDTGGGGVAATPTGSSTSVPANTVTVTTIPPANGGGHVVFGGKRRHESNEEWISSPSPGSVQGSAPPLSPSPGSQSHTYTNTMSNGYSSPLSSGSYDPYSPNGKMGKWIATLQNKVAKPPTAINRVNQDDHTCPPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1S7</accession>
    <name>A0A182P1S7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1S7"/>
    <dbReference type="STRING" id="199890.A0A182P1S7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000861-RA">
        <property type="protein sequence ID" value="AEPI000861-PA"/>
        <property type="gene ID" value="AEPI000861"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000861"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000861-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="100" mass="10411" checksum="FC08AC17FD410DAD" modified="2016-09-07" version="1">MLRPFPQAGRSDGGDKGARTTTLEDTLFRLSKLRERLKAMLRSPAHLIGHGPGAGGGGVVGLHSHASSPPHARPSLFDSCHRKIRLIGGGPVAFLGGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1T1</accession>
    <name>A0A182P1T1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein Sec61 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1T1"/>
    <dbReference type="STRING" id="199890.A0A182P1T1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000865-RA">
        <property type="protein sequence ID" value="AEPI000865-PA"/>
        <property type="gene ID" value="AEPI000865"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000865"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.820:FF:000001">
        <property type="entry name" value="Transport protein Sec61 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000865-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7776" checksum="3D08E34AFCA0FDD7" modified="2023-06-28" version="2">MDQLTKFYEPGRSFAKDSIRLIKRCTKPDRREFQKIAIATAIGFCIMGFIGFFVKLIHIPINNIIVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P219</accession>
    <name>A0A182P219_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">OBP47-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P219"/>
    <dbReference type="STRING" id="199890.A0A182P219"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000953-RA">
        <property type="protein sequence ID" value="AEPI000953-PA"/>
        <property type="gene ID" value="AEPI000953"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000953"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054577">
        <property type="entry name" value="OBP47-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052295">
        <property type="entry name" value="Odorant-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066:SF15">
        <property type="entry name" value="GH25962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066">
        <property type="entry name" value="ODORANT-BINDING PROTEIN 59A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22651">
        <property type="entry name" value="OBP47_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130771" description="OBP47-like domain-containing protein" evidence="8">
        <location>
            <begin position="28"/>
            <end position="211"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000953-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="211" mass="23156" checksum="1AC62B1088D1C395" modified="2016-09-07" version="1">MASSVVRSCSWAKVVVLLLGLVQLATAGEPNPACSTIPSVDKDSEEKCCDIPSIFPNETMQHCVGEIEKSTKPQLQKSCDIANCMLKKQNLLKSDNRVDLDKVKSFIKDTMQGSDEWKALAEKAVLEECLPMIEKDTSNVMSSLKSSMGDCNPVPALLIACAAAKFYAHCPSKDWTGSPMCDEWKSFLGKCSNSLEDMNAVYTTIESKKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P237</accession>
    <name>A0A182P237_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P237"/>
    <dbReference type="STRING" id="199890.A0A182P237"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000971-RA">
        <property type="protein sequence ID" value="AEPI000971-PA"/>
        <property type="gene ID" value="AEPI000971"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000971"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000971-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="739" mass="82147" checksum="8D3BC700B3C5F4E1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2N3</accession>
    <name>A0A182P2N3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2N3"/>
    <dbReference type="STRING" id="199890.A0A182P2N3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001167-RA">
        <property type="protein sequence ID" value="AEPI001167-PA"/>
        <property type="gene ID" value="AEPI001167"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001167"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071782">
        <property type="term" value="C:endoplasmic reticulum tubular network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF117">
        <property type="entry name" value="LP05237P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="950"/>
        </location>
    </feature>
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        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="878"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001167-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="950" mass="104538" checksum="A65F5F8260C22A70" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2N7</accession>
    <name>A0A182P2N7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2N7"/>
    <dbReference type="STRING" id="199890.A0A182P2N7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001171-RA">
        <property type="protein sequence ID" value="AEPI001171-PA"/>
        <property type="gene ID" value="AEPI001171"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001171"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001171-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="69" mass="8299" checksum="FCDF90182CF8E6B7" modified="2016-09-07" version="1">MSDKENKEKPKLDLGLLEEDDEFEEFPAEDWAGNKEDEEELSVWEDNWDDDNVEDDFNQQLRAQLEKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2Y4</accession>
    <name>A0A182P2Y4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 14">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 14"/>
    <dbReference type="AlphaFoldDB" id="A0A182P2Y4"/>
    <dbReference type="STRING" id="199890.A0A182P2Y4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001270-RA">
        <property type="protein sequence ID" value="AEPI001270-PA"/>
        <property type="gene ID" value="AEPI001270"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001270"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000003">
        <property type="entry name" value="Signal peptidase complex catalytic subunit SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S24/S26A/S26B/S26C" evidence="15">
        <location>
            <begin position="42"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001270-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="184" mass="20503" checksum="0799E6AE6C8859B3" modified="2016-09-07" version="1">MGMMDSLGLSGLAGGVQRMDKRQFLFQMLSFGMIVSSALMIWKGLMVVTGSESPIVVVLSGSMEPAFHRGDLLFLTNQDEPVRVGEIVVFKIEGRDIPIVHRVIKLHEKSNGTVKFLTKGDNNSVDDRGLYAPGQLWLTKKDIVGRARGFLPYVGMITIYMNEYPKLKYGILGLLALYVLVHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3G0</accession>
    <name>A0A182P3G0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3G0"/>
    <dbReference type="STRING" id="199890.A0A182P3G0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001445-RA">
        <property type="protein sequence ID" value="AEPI001445-PA"/>
        <property type="gene ID" value="AEPI001445"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001445"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000022">
        <property type="entry name" value="Blast:Metastasis-associated protein MTA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF29">
        <property type="entry name" value="METASTASIS ASSOCIATED 1-LIKE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001445-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="70" mass="8339" checksum="DD10E0E0AD768F3A" modified="2016-09-07" version="1">MYRVGDYVYVETSPTTPYQIRRIDELNKTPNGNVEAKVMCFYRRRDLPTPLVQLADKHQSVYHPTIKWHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3Q8</accession>
    <name>A0A182P3Q8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3Q8"/>
    <dbReference type="STRING" id="199890.A0A182P3Q8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001543-RA">
        <property type="protein sequence ID" value="AEPI001543-PA"/>
        <property type="gene ID" value="AEPI001543"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001543"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001543-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="441" mass="49642" checksum="8D3D6D745296E66D" modified="2016-09-07" version="1">MKVNDKKRLTEREKLELRERKRHRRQDRLLDRVKHEFEAMERDKVASAAEVEVATVAEKEHVSTISIAVPGSIMDNAQSPELRAYLAGQIARAACIFQVDEVIVFDDCGPSNQVTDRLGTIQTNEGSTSARRCCIQLARILQYLECPQYLRKFFFPMHNDLKFCGLLNPLDSQHHLRQQSEFVFREGIVTTKPIKGDKPGAFVNVGLLNDVLVNKTLEPNLRVTVKLPTGVDLKSKKIRGKVVPPSQPRQETGIYWGYTVRIANSLSQVFTKSPYRDGYDITIGTSDRGKNVHELEAKSLSYRHALVVFGGVLGLDPALENDQKLTADTVEDLFDEYLNTVPTQGSRTIRTEEAILISLAALGDKLKPAVAPKPFTSFEAIPQSQDTGIKQYAFNEKRSKVDLNELQKNRKLVRIARPLPSNPTSPQPLPVDKYGDMSRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3X2</accession>
    <name>A0A182P3X2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3X2"/>
    <dbReference type="STRING" id="199890.A0A182P3X2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001608-RA">
        <property type="protein sequence ID" value="AEPI001608-PA"/>
        <property type="gene ID" value="AEPI001608"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001608"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001608-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14849" checksum="30A56A3D7EF27C9F" modified="2016-09-07" version="1">MGKVQAQSNDDYDRIRYFYYIRPPHTPVPKDWWIDPVATTTESVTTLSASEETTLLLYDIFIPLLGSLIIVLNLIVVVSGVLLLRKGQQPYTTYMFLGNVAVSDLLTGFAVIFGQYAPRERRAEENCTLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P536</accession>
    <name>A0A182P536_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P536"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002023-RA">
        <property type="protein sequence ID" value="AEPI002023-PA"/>
        <property type="gene ID" value="AEPI002023"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002023"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="2">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002023-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="156" mass="17509" checksum="B58B5463B13F5DB0" modified="2016-09-07" version="1">MTNEAPKDLLNICRFCLSRDEENLIPMENVLLLTLTFQDILLFTGVQIEDDDKTLFAICVECTNKLKISTAFRNSCLKNDTAFRDLCSDLVAKTKAERVEAALALLAEAEAEEIVDGYRTPPTPHYDTIDLDSDDEFSYSANYTYGYLDACPICAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5P6</accession>
    <name>A0A182P5P6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P5P6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002237-RA">
        <property type="protein sequence ID" value="AEPI002237-PA"/>
        <property type="gene ID" value="AEPI002237"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002237"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057042">
        <property type="entry name" value="Beta-prop_SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057041">
        <property type="entry name" value="SCAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24017">
        <property type="entry name" value="Beta-prop_SCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24006">
        <property type="entry name" value="SCAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 20" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="465"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="897"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="23">
        <location>
            <begin position="436"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="957"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="1355"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="622"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1008"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1142"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1011"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="1149"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002237-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1477" mass="163332" checksum="ADCE670746097CF5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P675</accession>
    <name>A0A182P675_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Anamorsin homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Fe-S cluster assembly protein DRE2 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P675"/>
    <dbReference type="STRING" id="199890.A0A182P675"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002423-RA">
        <property type="protein sequence ID" value="AEPI002423-PA"/>
        <property type="gene ID" value="AEPI002423"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002423"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049011">
        <property type="entry name" value="Anamorsin_N_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20922">
        <property type="entry name" value="Anamorsin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="178"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="226"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002423-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="254" mass="27548" checksum="DF0BECBBABFDC8E4" modified="2016-09-07" version="1">MSFVQQGNHVLYLWGGTVGPEIEKEVNEIKSIPNVQVNVENVERLHLAEYGKSQFDVILAQVSTGNTTLVTLLVKLLKPKGKVVFRDDSAVSVDQARSNLLLSGFINIVASDNNVYVAEKPDYEVGSKSKLSFANKSKVAAVWKLDDDEEEERIDDEALLDEDDKAKPTAESLRVCGTTGKRKACKDCSCGLAEELDAEAKGKAVTDTSAAKSSCGSCYLGDAFRCATCPYLGMPAFKPGEKIVLTDTQMQADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6A3</accession>
    <name>A0A182P6A3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argonaute family. Piwi subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6A3"/>
    <dbReference type="STRING" id="199890.A0A182P6A3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002451-RA">
        <property type="protein sequence ID" value="AEPI002451-PA"/>
        <property type="gene ID" value="AEPI002451"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002451"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140965">
        <property type="term" value="P:secondary piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141009">
        <property type="term" value="P:transposable element silencing by piRNA-mediated mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02845">
        <property type="entry name" value="PAZ_piwi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04658">
        <property type="entry name" value="Piwi_piwi-like_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000014">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000003">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23278">
        <property type="entry name" value="Piwi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="PAZ" evidence="11">
        <location>
            <begin position="342"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="12">
        <location>
            <begin position="619"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002451-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="929" mass="105317" checksum="47F0E3CC78FB9030" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6W0</accession>
    <name>A0A182P6W0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein takeout</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6W0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002660-RA">
        <property type="protein sequence ID" value="AEPI002660-PA"/>
        <property type="gene ID" value="AEPI002660"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002660"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF25">
        <property type="entry name" value="IP09473P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131040" description="Protein takeout" evidence="4">
        <location>
            <begin position="35"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002660-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30162" checksum="8B3FD3286F466EAA" modified="2016-09-07" version="1">MSSAYWNLWSSVPRVVQLGLVFGLLSASLPSTCASFETKPDFIKTCRFDQANFVDCSTESVQGLFDKLVTGIEGLEHVGTIDPMKISKIRILQGDGPVSVNASLSKVVVTGFASTKVVRNVVSSKDFGWETHIRLPKMRLEGNYHMQGRILVIPLNGHGKCWFEPSGMDIIMRTTTDLYQKDGHVYYNVTATKVDYTISGLRLHMGNLFEGVKVLEDSTNQYLNDNWRPVSEALKPIIAKTIEDILLAIMQNIFHQLPADYFVADLPQGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6Y3</accession>
    <name>A0A182P6Y3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P6Y3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002683-RA">
        <property type="protein sequence ID" value="AEPI002683-PA"/>
        <property type="gene ID" value="AEPI002683"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002683"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18491">
        <property type="entry name" value="BACK_ABTB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18297">
        <property type="entry name" value="BTB_POZ_ABTB2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22913">
        <property type="entry name" value="HFD_ABTB2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059008">
        <property type="entry name" value="ABTB2/3_histone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052089">
        <property type="entry name" value="Ankyrin-BTB/POZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46071">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46071:SF2">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26281">
        <property type="entry name" value="Histone_ABTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1369"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="1699"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="446"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="706"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="788"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1280"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1872"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="608"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="731"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="812"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1289"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1310"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1873"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1889"/>
            <end position="1910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002683-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1910" mass="205281" checksum="4F51DD55DD616215" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7H0</accession>
    <name>A0A182P7H0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as a cell death activator during head development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDIT4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7H0"/>
    <dbReference type="STRING" id="199890.A0A182P7H0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002872-RA">
        <property type="protein sequence ID" value="AEPI002872-PA"/>
        <property type="gene ID" value="AEPI002872"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002872"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008258">
        <property type="term" value="P:head involution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045926">
        <property type="term" value="P:negative regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.40:FF:000003">
        <property type="entry name" value="Charybde, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.40">
        <property type="entry name" value="RTP801-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012918">
        <property type="entry name" value="RTP801-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038281">
        <property type="entry name" value="RTP801-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478">
        <property type="entry name" value="DNA-DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN DDIT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478:SF16">
        <property type="entry name" value="PROTEIN CHARYBDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07809">
        <property type="entry name" value="RTP801_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002872-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="150" mass="17050" checksum="9148B7576C366E43" modified="2016-09-07" version="1">MSANLAAIDELVEEFLKMELISVPPYPGQLGYLGSTKHLACTEVLLPADLLPRISSEMFEQSEKEPCGIRGCTIYIEFEDEPDNTRRIATMKTDPNTVSTFELYLTLKQDRRGWTSILPQFLKNLARGSTIMISPEFRLTKNKLYHAYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7J1</accession>
    <name>A0A182P7J1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P7J1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002894-RA">
        <property type="protein sequence ID" value="AEPI002894-PA"/>
        <property type="gene ID" value="AEPI002894"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002894"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.140.10:FF:000005">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF399">
        <property type="entry name" value="CHITINASE 6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="51"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="10">
        <location>
            <begin position="521"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="789"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="927"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1182"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18583" checksum="DFAEF2CA939974D4" modified="2016-09-07" version="1">MEKLYIFCCRLCLHDGSTNQLLEILSVKGLKEKIANIFNIEIASHDACTKNICLACFNETLNMEKQFRMYEEQKRTILDNQLRLQENSPETTGEVVCAPMTKPTATNMEENGDKNTVSTPERSSQGNLSEDKSPKTKRSANNSSGVNLEERDMHKSKSITQTSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8K3</accession>
    <name>A0A182P8K3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Katanin_con80 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8K3"/>
    <dbReference type="STRING" id="199890.A0A182P8K3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003256-RA">
        <property type="protein sequence ID" value="AEPI003256-PA"/>
        <property type="gene ID" value="AEPI003256"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="AEPI004462-RA">
        <property type="protein sequence ID" value="AEPI004462-PA"/>
        <property type="gene ID" value="AEPI004462"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003256"/>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004462"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028021">
        <property type="entry name" value="Katanin_C-terminal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13925">
        <property type="entry name" value="Katanin_con80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Katanin p80 subunit C-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004462-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="81" mass="9381" checksum="69C1CC11E212D429" modified="2016-09-07" version="1">MYDHCTRACDTLRVILSTFLPVIRENTDPWGACTIGVDVSREERQSKCLECKNWLLRIRCLPENPKMGSNLQQLQNMIVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA86</accession>
    <name>A0A182PA86_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit H is essential for V-ATPase activity, but not for the assembly of the complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PA86"/>
    <dbReference type="STRING" id="199890.A0A182PA86"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003840-RA">
        <property type="protein sequence ID" value="AEPI003840-PA"/>
        <property type="gene ID" value="AEPI003840"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003840"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00256">
        <property type="entry name" value="VATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000067">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="7">
        <location>
            <begin position="352"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003840-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="492" mass="56594" checksum="8F616682C726BD9B" modified="2016-09-07" version="1">MITNICLLLSVPPPLSKMTDVQDIMSSLPDDKIDMIAATSVLQQQAGDIRQTKPNWSSYMQSQMISQEDYACVSSLDKDKKAQAQYLQENAPQCAKTLLNMLSHVSKDQTIQYILVLIDDLLQEDRTRVQIFHDYANKKKESVWAPFLNLLNRQDGFIVNMASRVVGKLACWGQEQMPKSDLHFYLQWLKDQLTVANNEYIQSVGRCLQMMLRVDEYRFAFVTVDGISTLISILSSRVNFQVQYQLVFCLWVLTFNPLLAEKMNKFNVIPILADILSDCAKEKVTRIILAVFRNLIEKPEDAQVAKEHCIAMVQCKVMKQLTILEQRRFDDEDITGDVEFLTEKLQNSVQDLSSFDEYATEVKSARLEWSPVHKSAKFWRENAQRLNEKQYELLRILVHLLETSKDPLVLSVASYDIGEYVRHYPRGKHVIEQLGGKQLVMQLLAHEDPNVRYEALLAVQKLMVHNWEYLGKQLEKENEKAPQGNAPISGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAL5</accession>
    <name>A0A182PAL5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAL5"/>
    <dbReference type="STRING" id="199890.A0A182PAL5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003970-RA">
        <property type="protein sequence ID" value="AEPI003970-PA"/>
        <property type="gene ID" value="AEPI003970"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003970"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131180" description="Peptidase S1 domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="27"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003970-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="272" mass="30089" checksum="64C312F699553CE5" modified="2016-09-07" version="1">MQPITVGALASLLIVALCQIVTARKYVLGTIVCHAHATPGVSNPAIVSYLCLEFNQCTGGDACINISDCSRFAPHYNEPARWSDSLRNEFRTRVCKREKSNGMNVYKVCCQRTVKTNDNRKRGLDVTTVRLGEFDLSSTIDCDKRGELCALPPQDIAVERMILHEAYSARRKVNDIALIRLAQAASFNDKNLPNLNPNLTIHSSQMCAVTRIVSENCIGDTGGPLMSISQNGRYVLYGVHAYGANTCVAENELEVCVRVNSFIEWKLSKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAP2</accession>
    <name>A0A182PAP2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PAP2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003997-RA">
        <property type="protein sequence ID" value="AEPI003997-PA"/>
        <property type="gene ID" value="AEPI003997"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003997"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000071">
        <property type="entry name" value="TBC1 domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000041">
        <property type="entry name" value="TBC1 domain family member 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF333">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="212"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="798"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="866"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1299"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1446"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="866"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1189"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1302"/>
            <end position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003997-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1467" mass="160332" checksum="FDFC3ADA0C166B98" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB26</accession>
    <name>A0A182PB26_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PB26"/>
    <dbReference type="STRING" id="199890.A0A182PB26"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004131-RA">
        <property type="protein sequence ID" value="AEPI004131-PA"/>
        <property type="gene ID" value="AEPI004131"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004131"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004131-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="130" mass="14769" checksum="8650C361FC7E97C9" modified="2016-09-07" version="1">MVRISVLADALKCINNAEKRGKRQVLLRPNSKVVIRFLTVMMKHGYIGEFEVVDDHRSGKVVVNLTGRLNKAGIISPRFDTKVDDLERWTNNLLPSRQFGYVVLTTSGGIMDHEEARRKHLGGKILGYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBN6</accession>
    <name>A0A182PBN6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PBN6"/>
    <dbReference type="STRING" id="199890.A0A182PBN6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004341-RA">
        <property type="protein sequence ID" value="AEPI004341-PA"/>
        <property type="gene ID" value="AEPI004341"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004341"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04026">
        <property type="entry name" value="C2_PKC_alpha_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000012">
        <property type="entry name" value="Kinase C alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="199"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="379"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004341-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="449" mass="51771" checksum="3FB070207816CCCF" modified="2016-09-07" version="1">MNVHKRCEESVPNLCGCDHTERRGRIQLAITHSAGKLNIEVKQGRNLIPMDPNGSSDPYVKIKLIPDADNVKKKTKTIRASLNPVWNETLIFDLKAEDKDRRLLIEVWDWDRTSRNDFMGSLSFGISEILKNPVDGWFKLLTQEEGEYYNVPVPEEGADLVQLKSQMRKTSITKKIPMMGDKDVPHNMTKKDVIRATDFNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDIIIQDDDVECTMVEKRVLALSSKPPFLVQLHSCFQTMDRLYFVMEYVNGGDLMFQIQQCGKFKEPSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKDVCKGLLTKNPQKRLGCGARGEEDVRAHAFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDRQFTSEKTDLTPTDKLFMMNLDQTEFNGFSYLNPEFVQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC59</accession>
    <name>A0A182PC59_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">LIM domain kinase 1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="STRING" id="199890.A0A182PC59"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004514-RA">
        <property type="protein sequence ID" value="AEPI004514-PA"/>
        <property type="gene ID" value="AEPI004514"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004514"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09365">
        <property type="entry name" value="LIM2_LIMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000082">
        <property type="entry name" value="LIM domain kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000038">
        <property type="entry name" value="LIM domain kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000197">
        <property type="entry name" value="LIM domain kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000173">
        <property type="entry name" value="XLIM-Kinases2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF4">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0440">LIM domain</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="19">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="19">
        <location>
            <begin position="66"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="20">
        <location>
            <begin position="166"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="383"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="914"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1109"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1291"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1144"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1307"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1324"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004514-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1425" mass="155370" checksum="151B2B6182D4B14A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCD8</accession>
    <name>A0A182PCD8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCD8"/>
    <dbReference type="STRING" id="199890.A0A182PCD8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004593-RA">
        <property type="protein sequence ID" value="AEPI004593-PA"/>
        <property type="gene ID" value="AEPI004593"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004593"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004593-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="254" mass="26252" checksum="0AE82FD7654A31A0" modified="2016-09-07" version="1">MAKHHRIPTLAENINRSPRLSYLASHSQSASFMSEGGEITELMALDEAENLLHDRTASVQVISGSGGALCGSYGSYASGTLAGQLTPGGRMLVGGNVVGVGGAANGGGVNAGGISPGVGSYGEGSERLEELGIAFNEHLMYGAVGGKLLPNSPAVTILEMAGGGGHAAALRQKNFKRKSTATAAMVASGEQTSLNAIGLQLSVDRGGPQEWGEATRSYVKAQRRHAGRATFQGQVYNFLERPAGYKCFVYHVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCK6</accession>
    <name>A0A182PCK6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCK6"/>
    <dbReference type="STRING" id="199890.A0A182PCK6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004661-RA">
        <property type="protein sequence ID" value="AEPI004661-PA"/>
        <property type="gene ID" value="AEPI004661"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004661"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="12">
        <location>
            <begin position="71"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004661-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="400" mass="43829" checksum="129B681E8F9D27A3" modified="2016-09-07" version="1">MAARLIKKILDGEFGTLLAKFSAQLKDNWVKIYITSSSSPSASKADTNRAEPIVQTVAPFGTRSFASGTRKVTLIPGDGIGPEISAAVQKIFAVANVPIEWETVDVTPVRNPDGKFGIPQGAIDSVNRNKVGLKGPLMTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASNRVAEYAFKYAKDNNRKKVTVVHKANIMRMSDGLFLRCCRDMAQKYPEIKFEERYLDTVCLNMVQDPRKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNQHADKIQSACFETIKEAKYLTGDLGGKAKCSEYTNAICDRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCW6</accession>
    <name>A0A182PCW6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCW6"/>
    <dbReference type="STRING" id="199890.A0A182PCW6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004771-RA">
        <property type="protein sequence ID" value="AEPI004771-PA"/>
        <property type="gene ID" value="AEPI004771"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004771"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="740"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="685"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004771-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="871" mass="97430" checksum="88DAB03414695B86" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDG7</accession>
    <name>A0A182PDG7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDG7"/>
    <dbReference type="STRING" id="199890.A0A182PDG7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004972-RA">
        <property type="protein sequence ID" value="AEPI004972-PA"/>
        <property type="gene ID" value="AEPI004972"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004972"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004972-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="171" mass="17837" checksum="350D72B9AC63A309" modified="2016-09-07" version="1">MSKFIIDSMLPKYAQFQPFISSQISSQSISNSNSTVSQTPNSEGSPLTTGSEGSPNSPPTSKMYPFVSNHPTTHTSYSTMPGFSGLDDKSCSRYTESVMNSYPPMGVPGSASIAQFYQQAAAVSAASAGVGVDSLGSACSQLSSSVGGGQSGLPDITRHPWLVTGEYTNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDL8</accession>
    <name>A0A182PDL8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo repeat-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDL8"/>
    <dbReference type="STRING" id="199890.A0A182PDL8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005023-RA">
        <property type="protein sequence ID" value="AEPI005023-PA"/>
        <property type="gene ID" value="AEPI005023"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005023"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001000">
        <property type="entry name" value="Armadillo repeat containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000996">
        <property type="entry name" value="Armadillo repeat-containing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005023-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="617" mass="69108" checksum="FB1BB2A0C7D48AC4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEE1</accession>
    <name>A0A182PEE1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TROVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ro 60 kDa family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEE1"/>
    <dbReference type="STRING" id="199890.A0A182PEE1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005296-RA">
        <property type="protein sequence ID" value="AEPI005296-PA"/>
        <property type="gene ID" value="AEPI005296"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005296"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040322">
        <property type="entry name" value="TROVE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008858">
        <property type="entry name" value="TROVE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037214">
        <property type="entry name" value="TROVE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056800">
        <property type="entry name" value="vWA_Ro60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202">
        <property type="entry name" value="60 KDA RIBONUCLEOPROTEIN SSA/RO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN RO60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25045">
        <property type="entry name" value="vWA_Ro60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140864">
        <property type="entry name" value="TROVE domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50988">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="TROVE" evidence="8">
        <location>
            <begin position="57"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005296-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="667" mass="74845" checksum="4EF703FEC910C9C2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEV2</accession>
    <name>A0A182PEV2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEV2"/>
    <dbReference type="STRING" id="199890.A0A182PEV2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005457-RA">
        <property type="protein sequence ID" value="AEPI005457-PA"/>
        <property type="gene ID" value="AEPI005457"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005457"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131213" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="52"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="316"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005457-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="576" mass="64887" checksum="D07863447A69EC3C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFL2</accession>
    <name>A0A182PFL2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PFL2"/>
    <dbReference type="STRING" id="199890.A0A182PFL2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005719-RA">
        <property type="protein sequence ID" value="AEPI005719-PA"/>
        <property type="gene ID" value="AEPI005719"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005719"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 16" id="KW-0769">Symport</keyword>
    <keyword evidence="4 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="201"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005719-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="235" mass="25863" checksum="7E81DAD610B68767" modified="2016-09-07" version="1">MATSNPAFESDEPVSVVRPESNERTSEPATQRATGKSSAKVNQFQQHQPTPPPDLPGSGSSTRTSALLEMNLMKNIQKVQRDKWGKDIEFLLSCIALSVGLGNVWRFPFTALENGGGAFVIPYLIVLLLVGRPIYYLEMLISQFSSRGCINVYDASPAMRGIGVGQTYSTFIVMTYYASLMAVTMRYLIASFGDPLPWSECREEWNATCIDSRLVTNMAENSTATAVSSAELYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGJ6</accession>
    <name>A0A182PGJ6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGJ6"/>
    <dbReference type="STRING" id="199890.A0A182PGJ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006055-RA">
        <property type="protein sequence ID" value="AEPI006055-PA"/>
        <property type="gene ID" value="AEPI006055"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006055"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12294">
        <property type="entry name" value="RRM_Rrp7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12951">
        <property type="entry name" value="RRP7_Rrp7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001643">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034890">
        <property type="entry name" value="Rrp7A_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="42"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006055-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="256" mass="29435" checksum="D6F4CD8C098FACE6" modified="2016-09-07" version="1">MSSADEFSAIILRYKQSDPYCHQLFVKENASKATCKQKPSGRTLYVLNVPPYATEEALQQAFSSAGEVERVVLQEKPSSKESAPIEVMTKDVFCFKVAYVVFTKPGALKKLLKTKTINPLHSEEKPLLTGVAKWTKAYQERIPNPATLQQEIDQYMESYDRKVEEQKAEESNNAADDDGWVTVSKKNSGVFAQNQAVVKKLEKKLDEDRSTKELKNFYTFQIREAKKDDIISLRKKYDRDLKKMEQIKKAKRFKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHL4</accession>
    <name>A0A182PHL4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ITPR-interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHL4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006423-RA">
        <property type="protein sequence ID" value="AEPI006423-PA"/>
        <property type="gene ID" value="AEPI006423"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006423"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029325">
        <property type="entry name" value="ITPR-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043444">
        <property type="entry name" value="TESPA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17469:SF15">
        <property type="entry name" value="ITPR-INTERACTING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17469">
        <property type="entry name" value="SPERM SPECIFIC ANTIGEN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14722">
        <property type="entry name" value="KRAP_IP3R_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01257">
        <property type="entry name" value="KRAP_IP3R_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ITPR-interacting" evidence="2">
        <location>
            <begin position="518"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006423-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="675" mass="74239" checksum="EF90A843C6504D0D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIB8</accession>
    <name>A0A182PIB8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182PIB8"/>
    <dbReference type="STRING" id="199890.A0A182PIB8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006680-RA">
        <property type="protein sequence ID" value="AEPI006680-PA"/>
        <property type="gene ID" value="AEPI006680"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006680"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000083">
        <property type="entry name" value="7SK snRNA methylphosphate capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="8">
        <location>
            <begin position="63"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006680-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="274" mass="31506" checksum="189FC355AA45566D" modified="2016-09-07" version="1">MNSVTETQENTASNSTTNGNASRMKAPKQAVKERDKRQKKIFPYGNYNRYYGYRNQDAPPAEDPRLQAFVQRRELFESKRILDIGCNTGALTVQIALRCQPASIVGIDIDGDLVREARKHWKASVIASSRMGDTNGRQVGIELVEFKRANYIFEDAALLELEKPQFDVILCLSVTKWMQLNFGDDGLRTAFKRMYRQLHPGGVLVLEAQQWSSYKRRKKLTETIAHNFPNIKFLPSMFEQYLLSEEVGFSECSEIPVQRHTAVGFQRPLQMYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIR0</accession>
    <name>A0A182PIR0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIR0"/>
    <dbReference type="STRING" id="199890.A0A182PIR0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006823-RA">
        <property type="protein sequence ID" value="AEPI006823-PA"/>
        <property type="gene ID" value="AEPI006823"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006823"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131325" evidence="4">
        <location>
            <begin position="17"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006823-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="309" mass="35399" checksum="F4815D8921AFE4B7" modified="2016-09-07" version="1">MFRFVSCFALVAFATAAYTGSGHYSSKYTARKFYHHVADDEPKAAPAEHHHHEPQHHEEQDHFVDYYAPINYKFEYGVKDPHTGDHKTHWEERDGDVVKGAYTVLDADGSSRLVEYTADPHHGFNAVVKKIEHSHIPKKEHHVAPAHEESQEEHHHHHNHQEDEHPVEYKHANHQYHQQPEHHGSEIIGDYELFVALVALVAVAAAVDDYYAYPSYKFEYGVKDPHTGDHKSQWEHRDGDVVKGAYTLDEADGTKRVVEYSSDKHNGFQAHVKRVGHAHHPEVYGYQGGYGGSYGHGYGHSYSKLYKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIS3</accession>
    <name>A0A182PIS3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4794 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIS3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006836-RA">
        <property type="protein sequence ID" value="AEPI006836-PA"/>
        <property type="gene ID" value="AEPI006836"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006836"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131511" description="DUF4794 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006836-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29537" checksum="C6EC278BF4BC8AF5" modified="2016-09-07" version="1">KTETTALVLLVAAISVSAIRVDWNTNTGPIVPPTSTPAPVPQPPFREPAPVWEDQSDDIPNPNPYRYILPPPSRPKYNDITLEQRKQSQQQQQQQQPQNGNAQPATPASPTQTPTTAAPAGQIIDKPQQQPASGAPNAAPVHSQQPQQQQQQHVVPSLAVQYVPNKGLKYYAVVPKHTEVTYGSAKQALLATNDLYHHQQLQQHAQSKYDKYDKLNGKYNPKLKKYKAYEKVKYMPYIVYYDATKQQFYYTNVPSNMVVNNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIV8</accession>
    <name>A0A182PIV8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cysteine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIV8"/>
    <dbReference type="STRING" id="199890.A0A182PIV8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006871-RA">
        <property type="protein sequence ID" value="AEPI006871-PA"/>
        <property type="gene ID" value="AEPI006871"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006871"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20289">
        <property type="entry name" value="cupin_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012864">
        <property type="entry name" value="PCO/ADO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966:SF61">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07847">
        <property type="entry name" value="PCO_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006871-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29902" checksum="7EEFBB6FD2B541CF" modified="2016-09-07" version="1">MSTLYARVFRQAWATFEQTGAADAKFGSNLHALRRLVDQLTLADIGLEPSLVATETFQQPTKAPCTYVGVFENDRFAMSVFVLRENYTMPLHDHPQMHGLLRVVSGAVQICSYSEIARRDTVEPRDGTLRRHVLVVAEPEKIISSAAGDCAVLTPTERNFHEITAIGGPAAFFDILSPPYNTASQPQYYFYRKVPVPRHLAEMEPLGFGGPNKPSALEDERPRYVLETIPNPEHYYCDTVHYATPEFMYQPEEGGGRGGGSTAVDRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ07</accession>
    <name>A0A182PJ07_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heterochromatin protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJ07"/>
    <dbReference type="STRING" id="199890.A0A182PJ07"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006920-RA">
        <property type="protein sequence ID" value="AEPI006920-PA"/>
        <property type="gene ID" value="AEPI006920"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006920"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18631">
        <property type="entry name" value="CD_HP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00034">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000007">
        <property type="entry name" value="Chromobox protein homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000031">
        <property type="entry name" value="Heterochromatin protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="150"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006920-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="212" mass="23892" checksum="B1A6DA7321AB816D" modified="2016-09-07" version="1">MGRTKEPKNTNGNSGDDSETEEEYVVEKIVDRRERKGKVEYLLKWKGYDSGSNSWEPRENLDCPELIKAFEQSRTDAAAKKDAAAGGKKRTTTSKKKRTGGDSDDDATDDEGRGDDTASTKSQKSKNNDDDSKQADGDVAEEMNGFEKGYVPEKILGATEGDNELLFLIQWRDKDKAQLVKSKEARKHCPQLVIDFYEERLIWQTVDQSQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ11</accession>
    <name>A0A182PJ11_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJ11"/>
    <dbReference type="STRING" id="199890.A0A182PJ11"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006924-RA">
        <property type="protein sequence ID" value="AEPI006924-PA"/>
        <property type="gene ID" value="AEPI006924"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006924"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000008">
        <property type="entry name" value="Stomatin-like protein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="52"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006924-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="397" mass="43120" checksum="3D5D19664EAA82DC" modified="2016-09-07" version="1">MIRSSAFISRLPLRGIAAATLNSNGGLLQSPTSSLAALQTTQVRHRSTPINTVIMFVPQQEAWIVERMGKFHRILEPGLNVLLPVVDRVKYVQSLKEIAIDVPKQSAITSDNVTLSIDGVLYLRILDPYLASYGVEDPEFAITQLAQTTMRSELGKMSLDKVFRERESLNISIVESINKASEAWGISCLRYEIRDIKLPSRVHEAMQMQVEAERRKRAAILESEGVRAADINVAEGKRQSRILASEAQKQEEINRANGEAAAIMALADARAKSLKIVAESLANEHGRSAASLSVAEKYVVAFEKLAKQNNTLIVPSTASDVTSMVAQAMQIYNNLSNTSALSRASGQPGHGDGQTAEAQSVLGTLNETSSKLDATLPPLESHHHHQGDNSMGGSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ29</accession>
    <name>A0A182PJ29_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJ29"/>
    <dbReference type="STRING" id="199890.A0A182PJ29"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006943-RA">
        <property type="protein sequence ID" value="AEPI006943-PA"/>
        <property type="gene ID" value="AEPI006943"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006943"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000013">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000033">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="47"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="285"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006943-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="487" mass="55072" checksum="E2D25477836C6FDF" modified="2016-09-07" version="1">MREIVHLQAGQCGNQIGSKFWEIISDEHGIDPTGHYHGDTDLQLERIDVYYTEVNGNKYVPRAVLVDLEPGTMDSVRQSPYGALFRPDNFVYAQSGAGNNWAKGHYTEGAELVDNVLDVIRKETEACDCLQGFQLAHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDDTFCIDNEALYDICFRTLKLTSPTYGDLNHLVSLIEASDQTNCIDNEALYDICFRTLKIFNPTYPDLNHLISVTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAKGSQQYRALTVPELTAQLFDAKNMMTACDPRHGRYLTCAAIFRGTMSMKEVDQQMLNIQSKYSSYFVEWIPNNVKVAVCDIAPRGLKMSATFIGNTTAIQEIFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLISEYQQYQDADVEDYDEMEEIPEEEQQQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ70</accession>
    <name>A0A182PJ70_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PJ70"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006984-RA">
        <property type="protein sequence ID" value="AEPI006984-PA"/>
        <property type="gene ID" value="AEPI006984"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006984"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007424">
        <property type="term" value="P:open tracheal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000013">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000321">
        <property type="entry name" value="Cadherin-related tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000447">
        <property type="entry name" value="Cadherin-related tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000108">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000143">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000144">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000154">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000081">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000134">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000340">
        <property type="entry name" value="Protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF133">
        <property type="entry name" value="CADHERIN-RELATED FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25374">
        <property type="entry name" value="Cadherin_FAT4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131532" description="Cadherin domain-containing protein" evidence="15">
        <location>
            <begin position="20"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="49"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="150"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="264"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="382"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="489"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="594"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="702"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="923"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="1027"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="1132"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="1252"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="1358"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="1463"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="1591"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="1683"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006984-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1785" mass="193592" checksum="E64C079CF53AD288" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJP7</accession>
    <name>A0A182PJP7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GCM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJP7"/>
    <dbReference type="STRING" id="199890.A0A182PJP7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007161-RA">
        <property type="protein sequence ID" value="AEPI007161-PA"/>
        <property type="gene ID" value="AEPI007161"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007161"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.670">
        <property type="entry name" value="GCM domain, large subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3530">
        <property type="entry name" value="GCM motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039791">
        <property type="entry name" value="GCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036115">
        <property type="entry name" value="GCM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043020">
        <property type="entry name" value="GCM_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043021">
        <property type="entry name" value="GCM_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003902">
        <property type="entry name" value="Tscrpt_reg_GCM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12414">
        <property type="entry name" value="GLIAL CELLS MISSING RELATED/GLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12414:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR GLIAL CELLS MISSING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03615">
        <property type="entry name" value="GCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90073">
        <property type="entry name" value="GCM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50807">
        <property type="entry name" value="GCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GCM" evidence="7">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007161-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="637" mass="69354" checksum="F4A46F36C10DD257" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKA9</accession>
    <name>A0A182PKA9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">dTCF</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Binds to the beta-catenin homolog arm or to gro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCF/LEF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKA9"/>
    <dbReference type="STRING" id="199890.A0A182PKA9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007375-RA">
        <property type="protein sequence ID" value="AEPI007375-PA"/>
        <property type="gene ID" value="AEPI007375"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007375"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990907">
        <property type="term" value="C:beta-catenin-TCF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007476">
        <property type="term" value="P:imaginal disc-derived wing morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007500">
        <property type="term" value="P:mesodermal cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072091">
        <property type="term" value="P:regulation of stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007435">
        <property type="term" value="P:salivary gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007367">
        <property type="term" value="P:segment polarity determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035277">
        <property type="term" value="P:spiracle morphogenesis, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21996">
        <property type="entry name" value="HMG-box_TCF7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000011">
        <property type="entry name" value="Pangolin, isoform Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000001">
        <property type="entry name" value="transcription factor 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013558">
        <property type="entry name" value="CTNNB1-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024940">
        <property type="entry name" value="TCF/LEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373:SF38">
        <property type="entry name" value="PROTEIN PANGOLIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373">
        <property type="entry name" value="TRANSCRIPTION FACTOR 7 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08347">
        <property type="entry name" value="CTNNB1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0709">Segmentation polarity protein</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="HMG box" evidence="15">
        <location>
            <begin position="361"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="13">
        <location>
            <begin position="361"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="232"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="487"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="641"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="663"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053480"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007375-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="729" mass="77505" checksum="1DB8C81F04C58E47" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKQ5</accession>
    <name>A0A182PKQ5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKQ5"/>
    <dbReference type="STRING" id="199890.A0A182PKQ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007522-RA">
        <property type="protein sequence ID" value="AEPI007522-PA"/>
        <property type="gene ID" value="AEPI007522"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="606"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
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            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
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            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
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            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1054"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="482"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="969"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="377"/>
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    </feature>
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        <location>
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    </feature>
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        </location>
    </feature>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007522-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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    </evidence>
    <sequence length="1135" mass="119043" checksum="2F5B4CCD9FCB4C0D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKY9</accession>
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        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL9m</fullName>
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        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L9, mitochondrial</fullName>
        </alternativeName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL9 family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A182PKY9"/>
    <dbReference type="STRING" id="199890.A0A182PKY9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007606-RA">
        <property type="protein sequence ID" value="AEPI007606-PA"/>
        <property type="gene ID" value="AEPI007606"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007606"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="39S ribosomal protein L9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
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    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="9">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007606-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="261" mass="29325" checksum="41636764761ADC94" modified="2016-09-07" version="1">MLGNVVKVLGNGLCATQSVLLQSSRNTFVLKRRFPPNLYKKNQKPGKLRGRHFVYDLVEDTTIKKKPNLEVVLTTFVEGIGSKGDVVSLKPNEAYNKLLLPGLAVYKTPENVAKYATEKDEKEAEVHSSAYAQRTVNKLESLILAVVMNKDHPWVIEPWHIKMSLRKAGYYVPDSAITLPETPITGPDLLKQNKEFYCTVTVNNLEKARVRCRIHHWSTEPSDRLPYVFEHWKLDAEPLFGDAGPAASVGNAKPESRQSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL87</accession>
    <name>A0A182PL87_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Shugoshin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PL87"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007704-RA">
        <property type="protein sequence ID" value="AEPI007704-PA"/>
        <property type="gene ID" value="AEPI007704"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007704"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007704-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="58838" checksum="EE28E2033D8710B2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLE3</accession>
    <name>A0A182PLE3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182PLE3"/>
    <dbReference type="STRING" id="199890.A0A182PLE3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007761-RA">
        <property type="protein sequence ID" value="AEPI007761-PA"/>
        <property type="gene ID" value="AEPI007761"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007761"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF162">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007761-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="358" mass="41547" checksum="6A07B693B138C86F" modified="2016-09-07" version="1">MAQILTNIYDWYRDLMDNQSDPRVADWPMMSSPFPTLGLCIFYAYFSKSLAPKLMEKRKPMDLRNTLVIYNLFQTIFSTWIFYEYLQSGWGGHYSFRCQPVDYSDNPLALRMARTCWWYYVSKFTEFFDTLFFILRKKTQHVSTLHVIHHGCMPFSVWMGMKFAPGGHSTFFAMLNSFVHIVMYFYYMVAALGPKYQKYIWWKKYLTAFQMAQFVAIFTHQFQLLFTECDYPKGFMVWIGLHGVMFLFLFSDFYKQAYNKRVGRAKREAEALLAKSHANGKLHNGDIVNNNQGACMPVLNDDDELHQRKVTGNGIYLNGGAKTANSYSNGNSNGFVESIQQSNGGIGENGGARVRKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLV8</accession>
    <name>A0A182PLV8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLV8"/>
    <dbReference type="STRING" id="199890.A0A182PLV8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007930-RA">
        <property type="protein sequence ID" value="AEPI007930-PA"/>
        <property type="gene ID" value="AEPI007930"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007930"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16027">
        <property type="entry name" value="SGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000026">
        <property type="entry name" value="N-sulphoglucosamine sulphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="SGSH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="SGSH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131447" description="Sulfatase N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="N-sulphoglucosamine sulphohydrolase C-terminal" evidence="7">
        <location>
            <begin position="422"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="780"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="887"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1101"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="684"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1107"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1153"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007930-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1226" mass="137322" checksum="E8E906EB1611D391" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMK7</accession>
    <name>A0A182PMK7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Scavenger receptor class B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an olfactory role that is not restricted to pheromone sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMK7"/>
    <dbReference type="STRING" id="199890.A0A182PMK7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008181-RA">
        <property type="protein sequence ID" value="AEPI008181-PA"/>
        <property type="gene ID" value="AEPI008181"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008181"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF88">
        <property type="entry name" value="DEBRIS BUSTER, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008181-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40112" checksum="F4809DE16B4A8D2A" modified="2016-09-07" version="1">MHTGHTGMEKFGYFDKLNGLDHLPHWDGEPCRSIQASEGSFFPPRDITQKDVVYIYDKDLCRTLPLVYREPVEKDGISADLYTLAEDAYGPPNENNSCFDHSHYKKYYGLQNISPCQYGAPVYISNPHFYQSDPQLLDAVEGLAPNAEQHKTYFKIQPKLGVPLEGQVRVQLNLLVEKAPNVMATKDFRDFVFPIMWLEEGVSELTPPIRRWIYLATVFAPTALPILSYGMILTGAFAMIYVFVRAYKNFVFTDDPTTELLEMGRRSLRRGSHLISNGQHRILHRDSYILLKANGTGVVVGGELDTSGTGTEGVHGGHSNNNNHLHHNHNLLHSHHHLYIQPKDQSLLAEEDSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMN0</accession>
    <name>A0A182PMN0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein Nup205</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PMN0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008204-RA">
        <property type="protein sequence ID" value="AEPI008204-PA"/>
        <property type="gene ID" value="AEPI008204"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008204"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008204-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2088" mass="234464" checksum="0AD42DF14D66DA88" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN76</accession>
    <name>A0A182PN76_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PN76"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008401-RA">
        <property type="protein sequence ID" value="AEPI008401-PA"/>
        <property type="gene ID" value="AEPI008401"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008401"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01463">
        <property type="entry name" value="vWA_VGCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000007">
        <property type="entry name" value="Calcium voltage-gated channel auxiliary subunit alpha2delta 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000057">
        <property type="entry name" value="Voltage-dependent calcium channel subunit alpha-2/delta-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF63">
        <property type="entry name" value="STRAIGHTJACKET, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131515" description="VWFA domain-containing protein" evidence="17">
        <location>
            <begin position="22"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1498"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1681"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="18">
        <location>
            <begin position="685"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008401-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1706" mass="194241" checksum="077D792629E46420" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNZ0</accession>
    <name>A0A182PNZ0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ornithine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182PNZ0"/>
    <dbReference type="STRING" id="199890.A0A182PNZ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008669-RA">
        <property type="protein sequence ID" value="AEPI008669-PA"/>
        <property type="gene ID" value="AEPI008669"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008669"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008669-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="485" mass="53099" checksum="30DD67288442211C" modified="2016-09-07" version="1">MLRQVSKSELVAKQFDKLLVPLFSTQSSKPPGLRHSSTSAGTGSLNKHHSLLAGCRDKYGFAKINEMAQNGYGHAATQLKAQPKSQAVFDREDKFGAHNYHPLPVALARGEGVYVWDVEGKRYYDFLSAYSAVNQGHCHPKIVKALTEQAQVLTLTSRAFYSNVLGEYEQFVTNLFGYDKVLPMNTGVEGGETACKLARKWGYKVKQIPENKAKIVFAEGNFWGRTLAAVSSSNDPSSYSGFGPFMPGFELVPYNDTAALEKALQDPHVCAFMVEPIQGEAGVVVPDDGYLRKVRELCSKYNVLFIADEVQTGLSRTGRMLAVDHEDVKPDILILGKALSGGVYPVSAVLANDPVMLCIQPGEHGSTYGGNPLGCKVAIAALQVLVEENLSENAERMGQLLRSSLRELPKDVVSIVRGKGLLNAIVINPNFDAWEVCLRLKENGLIAKPTHGDIIRFAPPLTINQEQLEDCLHIIKTTIMSFVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNZ9</accession>
    <name>A0A182PNZ9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNZ9"/>
    <dbReference type="STRING" id="199890.A0A182PNZ9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008678-RA">
        <property type="protein sequence ID" value="AEPI008678-PA"/>
        <property type="gene ID" value="AEPI008678"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008678"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008678-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="201" mass="22657" checksum="21E9E3EE58F41525" modified="2016-09-07" version="1">MGQLRARRKAAKMLVAVVIMFAGCYFPVHMLNVARYTVDIGQSDIVAVLSLFSHWLCYANSAVNPVIYNFMSGKFRREFKNALEKCRCLRSSHAYGGRVGGYDDRSLCHTATRLNVSPSTRSNYHLASQHTQQTSFNGSRHQHGRNSINHPGSLQPQISPISVEERLALTKSMDVTSSMEHGGSGELLNWSRSYHFRYNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP83</accession>
    <name>A0A182PP83_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PP83"/>
    <dbReference type="STRING" id="199890.A0A182PP83"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008762-RA">
        <property type="protein sequence ID" value="AEPI008762-PA"/>
        <property type="gene ID" value="AEPI008762"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008762"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="211"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008762-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="288" mass="32413" checksum="68FF6243997BC05A" modified="2016-09-07" version="1">MSKTPTKAELKAEIQKILKDANLEETAAKKVRLQLEKNLKCDLSNRKKEVDELVMDYVNSQASSDGEEDEDEDEDDDEYAGNGKGKLNSSKPKGNSDYEDEEEEEDDDDEDEDFSEEEKPKGRKSAGKRTTPAKRGPAKKKKRTSDSEDEESDEEEQGSDDDYNPRGSGKGSKGGKKKRNDSDSDSDGDWKQSKPAKGKKSAGGGAKRSSGYTRPYKLSPDLAELCGAESLPRHEVVRKVWAIIKERNLYDPKNRQFAICDDQLKKVIGTKRFRTFGMLKYLKPHFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPN0</accession>
    <name>A0A182PPN0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPN0"/>
    <dbReference type="STRING" id="199890.A0A182PPN0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008909-RA">
        <property type="protein sequence ID" value="AEPI008909-PA"/>
        <property type="gene ID" value="AEPI008909"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008909"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="81"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008909-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="368" mass="41966" checksum="B49EF4A3A5E18AE5" modified="2016-09-07" version="1">MTRTRSLPSKAFEGCEDKRSEQRLLHKWTRYSSAKLEEVEETLLSALRKPFESIFVEVGQCVGTNDKIRTVALNRESDNIPVLLLHGLGAGVGLWVLNLDAIAEHRPMYAIDILGFGRSSHPKYDEDPIAAERQFVASIEAWRVAMGLERMYILGHSMGGYLACSYAITHPQRVAGLILADPWGFMEPPQRIKRKYWIRILYRTARKMNFYPLTVVRMAGPTAAWILSRRRTDITSRFEGIVPDERIVADYLHLVNAQKPSGETGFCAIQKNFGWPINPMLKRIDQIDPTIPMTFIYGSESWIDFEAGEVTKEKRSGCFVQVKIIDNASHHLYADFPDIFNQHVNEACTTYDKRINAQNKVTELVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ48</accession>
    <name>A0A182PQ48_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQ48"/>
    <dbReference type="STRING" id="199890.A0A182PQ48"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009078-RA">
        <property type="protein sequence ID" value="AEPI009078-PA"/>
        <property type="gene ID" value="AEPI009078"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009078"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009078-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26493" checksum="162ED41AA670DFDD" modified="2016-09-07" version="1">MNSILITGCNRGLGLGLVKVLVGLPAPQPTHIIATYRDPAKSQDLLALAKQHNNIVPLQFDVKNFDQYDQFAKDVDALLQGAGLNVLFNNAGISPKSTRLNFTKQDDLVDTFVVNTVAPIMMTKAFVPLLKKASDNSASAPVGPQRACIVNMSSILGSIEANREGGLYGYRTSKAALNAATKSMSLDLKGHKIMAVALHPGWVQTDMGGAKAPLTVEQSCSAIVRTLLSLNESNNGGFLQYDGKALPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQC0</accession>
    <name>A0A182PQC0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">28S ribosomal protein S22, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQC0"/>
    <dbReference type="STRING" id="199890.A0A182PQC0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009150-RA">
        <property type="protein sequence ID" value="AEPI009150-PA"/>
        <property type="gene ID" value="AEPI009150"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009150"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019374">
        <property type="entry name" value="Ribosomal_mS22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10245">
        <property type="entry name" value="MRP-S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009150-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="43884" checksum="557E8ECCE1620CA2" modified="2016-09-07" version="1">MWKLWKELHLIGGLARRRSTVANTSHTLCRLFSSTVQTESEPFLSYDKDPAPAFMRDDVQQLLKSITRLELDKVFRKRSVKDNTVEYRFMTDEQLRRELLHSIEQAQQMLQMPPVVQEQKDSCRIISKDGALKSLSTSKFVFTDITYGLKNSQRSIVVRHPDGTLQEAPYEMRKRLNQIYFPLTGRSIHQPPMFEDVYLQRLLEEGKYEFVLDRACVQFEPYEKDYHQITAKVYHHVNESRSFDALRSTRHFGPFVFFLVWHKLIDDLLLDMIKQDYLRNGIELIALYSTLHGTAIDEDVKQTALQTQMPSLFEAAEKSVDELKQDELFLSIIEQFVNSQATKKVQLNLAVQAYRELAMEKLRLAQGIRRMHGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQE7</accession>
    <name>A0A182PQE7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQE7"/>
    <dbReference type="STRING" id="199890.A0A182PQE7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009177-RA">
        <property type="protein sequence ID" value="AEPI009177-PA"/>
        <property type="gene ID" value="AEPI009177"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009177"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="731"/>
        </location>
    </feature>
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        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="227"/>
        </location>
    </feature>
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    </feature>
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            <end position="390"/>
        </location>
    </feature>
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        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="588"/>
        </location>
    </feature>
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        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
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        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
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    </feature>
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        <location>
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            <end position="730"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009177-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="803" mass="85470" checksum="F6BEDCEC3950C4CD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQZ0</accession>
    <name>A0A182PQZ0_9DIPT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQZ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009371-RA">
        <property type="protein sequence ID" value="AEPI009371-PA"/>
        <property type="gene ID" value="AEPI009371"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009371"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="73"/>
        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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            <end position="475"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
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            <end position="58"/>
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            <end position="161"/>
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    </feature>
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            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009371-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="595" mass="61332" checksum="DDCA6A40E06016E5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRJ9</accession>
    <name>A0A182PRJ9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19369"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:11600"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16367"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.85"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PRJ9"/>
    <dbReference type="STRING" id="199890.A0A182PRJ9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009583-RA">
        <property type="protein sequence ID" value="AEPI009583-PA"/>
        <property type="gene ID" value="AEPI009583"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009583"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025785">
        <property type="entry name" value="SETD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51565">
        <property type="entry name" value="SAM_MT85_SETD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009583-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="239" mass="27563" checksum="0397D32CD5A1D8E6" modified="2016-09-07" version="1">MSNHGSAPPPKALSKGKVKELNGLVEELMQYGFREANGTDELLAQHRNMAGVLDRIRRVEPKLRTTNGRPRMENVHHFTQWALEQGCGRAENVRIAEQTEFGGLGLESCGHIPAGESIITVPRRLFFYVTNEPRYRKLLELMPGAMMSEQGNIMLALALIMERFRVKSYWKPYLDLLPDRYTTPLYYTTDDMGELVDTEAFLPALKLCKHIARQYGFIRKFVQEKVDELRDCFTYDVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRZ5</accession>
    <name>A0A182PRZ5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRZ5"/>
    <dbReference type="STRING" id="199890.A0A182PRZ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009730-RA">
        <property type="protein sequence ID" value="AEPI009730-PA"/>
        <property type="gene ID" value="AEPI009730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009730"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131683" description="EGF-like domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009730-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="459" mass="49380" checksum="DCD686C3BE12200D" modified="2016-09-07" version="1">MDTNGRVLRSCRLALLGLLVCGLAGRASARHAYGPKCCPPNEVLLWCPPVCEPTCDNDCVPTPSGVPMETCVCKPGFVRHNGCCIEKCECPAPHPPTLPPTPCPPAPMTTPKPCGPTFYGVSGSGEVPMFQAPQYHPPSVPVHPRPYVHPNPYSMTSQSQNLSQSSNYLYRPVRPCPPKPMPTTTVSPFDVCPPNEVQQPSPVCCEETCTTNCAAVLCPIQPPTGPLVCTCDAGFVRHEGRCIRREECPVEQPVKFCGPNARYSPCTPCCQPTCDNDCSKIFCIAACTGPPTCVCNEGYVLHNGRCILPSECPRKCPATTPAPPPCVYHHSYPECPCKCAGPPSTVAPSCTECPWKCPATTPAPVHMRYSHKPCSAVCPPGASLRPFKPCCVDTCTTDCRLVRCAESFTGPPTCVCDYGLVMHNNQCIPREHCPSKSEPPCGSGAVSYSYSSHPFQRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS06</accession>
    <name>A0A182PS06_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PS06"/>
    <dbReference type="STRING" id="199890.A0A182PS06"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009741-RA">
        <property type="protein sequence ID" value="AEPI009741-PA"/>
        <property type="gene ID" value="AEPI009741"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009741"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009741-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20888" checksum="283D8B5CCF4B3E39" modified="2016-09-07" version="1">MVQPGLDALAERDLMGAIQIPLQNGVKFVDGLDGFPAFGVTSEADLKSPFKLILSDHLQDFAIIATVRPQSSSGGWVFSVVNSLDTVVQLGLLLEPTAAGDEWNATLYYTDAKKERISQPLASFQVPYGKSWMKMIFKVLPDQVVFYYNCLEAGVVPVKKEPRKLVFDSASTVYIGQAGPVLKQKFEVSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSA3</accession>
    <name>A0A182PSA3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSA3"/>
    <dbReference type="STRING" id="199890.A0A182PSA3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009838-RA">
        <property type="protein sequence ID" value="AEPI009838-PA"/>
        <property type="gene ID" value="AEPI009838"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009838"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="17"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009838-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="553" mass="60447" checksum="6AB2CB1390879306" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSB5</accession>
    <name>A0A182PSB5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
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        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
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        <property type="gene ID" value="AEPI009850"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI009850"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000034">
        <property type="entry name" value="amyloid beta A4 precursor protein-binding family B member 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Amyloid beta A4 protein-binding family B member"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="APBB1/2/3"/>
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        <property type="entry name" value="WW_dom_sf"/>
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        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF8">
        <property type="entry name" value="PROTEIN FE65 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS01179"/>
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            <dbReference type="PROSITE" id="PS50020"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="79746" checksum="1A2CFDD7218B9F72" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSD5</accession>
    <name>A0A182PSD5_9DIPT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <organism evidence="2 3">
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
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    <dbReference type="EnsemblMetazoa" id="AEPI009870-RA">
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        <property type="gene ID" value="AEPI009870"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009870"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009870-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="63" mass="6578" checksum="BF503F8EF5BCE976" modified="2016-09-07" version="1">MSLMQAMMIAARKVVALKEAAEVVEQYQGYQGNQDSVLFGGGGVSGGGGSSTPSDTTKYNQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSN8</accession>
    <name>A0A182PSN8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <organism evidence="1 2">
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            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AEPI009974"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009974"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112:SF10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00697">
        <property type="entry name" value="DM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="191" mass="22238" checksum="E9073A6226E74052" modified="2016-09-07" version="1">MHATSGLRRSMLTLTGYIKPVCTALLPKLTRDRNFDVHIDKLERLGEAGEYFTYNYTYEKISDMKFNMGAHVQQLKELDDSFTVKALMARADLADGSEYEVMMDLQKPLCEWMRTIYKAYFYEELAKVSNFPHYDTCPLPVAEYVMENYVLDTEPYSEMMSEGRWKMEMMLMKGDSVCSGILMMNTVKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PT25</accession>
    <name>A0A182PT25_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PT25"/>
    <dbReference type="STRING" id="199890.A0A182PT25"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010111-RA">
        <property type="protein sequence ID" value="AEPI010111-PA"/>
        <property type="gene ID" value="AEPI010111"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010111"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17948">
        <property type="entry name" value="DEADc_DDX28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF13">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="126"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="342"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010111-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="517" mass="57789" checksum="CE4F7659B2E62CF6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTR9</accession>
    <name>A0A182PTR9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin fusion degradation protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTR9"/>
    <dbReference type="STRING" id="199890.A0A182PTR9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010355-RA">
        <property type="protein sequence ID" value="AEPI010355-PA"/>
        <property type="gene ID" value="AEPI010355"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010355"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.50:FF:000001">
        <property type="entry name" value="Ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000002">
        <property type="entry name" value="ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="118"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010355-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="303" mass="34339" checksum="8A870894BD220C15" modified="2016-09-07" version="1">MFQFNGFNMMFPDHSRPFNTTYKCYSVSMLPGNERQDVENGGKIIMPPSALDQLTRLNVVYPMLFKITNGSINRSTHAGVLEFVADEGKIYMPYWMMHNLALDQGDIVEIESVSIPVATYSKFQPQSVEFLDITNPKAVLENCLRNFACLTTGDLIAIKYNNTTYELSVLETKPGPAVTIIECDMNVEFAPPVGYTEPERKEKEEEPMTIDPTELMPEPIGFVAFKGEGTRLDGKKKKDNGANEAPSAQRQAYVRGIPDYDHPYGLLRFDRSVRKTDQVESKVEDSKFQEFQGEGFNLKKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU88</accession>
    <name>A0A182PU88_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ANKLE2 third alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ANKLE2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU88"/>
    <dbReference type="STRING" id="199890.A0A182PU88"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010524-RA">
        <property type="protein sequence ID" value="AEPI010524-PA"/>
        <property type="gene ID" value="AEPI010524"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010524"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000072">
        <property type="entry name" value="Ankyrin repeat and LEM domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056237">
        <property type="entry name" value="ANKLE2_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF4">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24567">
        <property type="entry name" value="ANKLE2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="ANKLE2 third alpha/beta" evidence="9">
        <location>
            <begin position="268"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="761"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="816"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="762"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010524-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="951" mass="105752" checksum="DDB2F8A069FC91E1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUC4</accession>
    <name>A0A182PUC4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182PUC4"/>
    <dbReference type="STRING" id="199890.A0A182PUC4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010560-RA">
        <property type="protein sequence ID" value="AEPI010560-PA"/>
        <property type="gene ID" value="AEPI010560"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010560"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010560-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="159" mass="17367" checksum="45D68B0C6DEEF998" modified="2016-09-07" version="1">MTWSGNVCSRKLYHFGQLRQLFALSIPKGCHKSSPAAHGLRHHHHSIEVDQAEQDQNLFFLDGPGGTGKSFLLEKILANTRRHGKIAIATASSGIAALLLTGGKTVHSTFKLPLLLNECTHCNIPVQSSLANLMRQASIIVWDEASMSSRYTLEAVVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUF1</accession>
    <name>A0A182PUF1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUF1"/>
    <dbReference type="STRING" id="199890.A0A182PUF1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010587-RA">
        <property type="protein sequence ID" value="AEPI010587-PA"/>
        <property type="gene ID" value="AEPI010587"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010587"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF7">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="175"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="10">
        <location>
            <begin position="461"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="7">
        <location>
            <begin position="461"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010587-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="54253" checksum="F1FD67DF9F32BE22" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUT4</accession>
    <name>A0A182PUT4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0506 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUT4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010721-RA">
        <property type="protein sequence ID" value="AEPI010721-PA"/>
        <property type="gene ID" value="AEPI010721"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010721"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021712">
        <property type="entry name" value="UPF0506"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11703">
        <property type="entry name" value="UPF0506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0506" evidence="2">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010721-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="254" mass="27495" checksum="101274D30B6C2AAC" modified="2016-09-07" version="1">MRTSARKCFSRNNNRSDTENRFGGDDGGASLTQKTCALNGEYCQTHMECCSGSCLTFSYKCVPLNPPTSTLTVQQDSTPQPNNFSNRIGEETSPVSTTIQSSTPKACAAVGEYCLTASECCSKSCLSFAYKCVNRYDILAAADKNSPTSSISTSNRFGNTGVDTQTETRKCTSNGLYCFHNKECCSGACYKSICSTEIHIGVPESELTRPSVANGPYIPVKNLDDLITRFGGQIVTTEQNASRQEKRCKIIGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV68</accession>
    <name>A0A182PV68_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein REV1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PV68"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010855-RA">
        <property type="protein sequence ID" value="AEPI010855-PA"/>
        <property type="gene ID" value="AEPI010855"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010855"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12145">
        <property type="entry name" value="Rev1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000018">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="311"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="17">
        <location>
            <begin position="620"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="454"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1122"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1247"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010855-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1452" mass="161153" checksum="9F593407319AF9A6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVR3</accession>
    <name>A0A182PVR3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MEMO1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVR3"/>
    <dbReference type="STRING" id="199890.A0A182PVR3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011050-RA">
        <property type="protein sequence ID" value="AEPI011050-PA"/>
        <property type="gene ID" value="AEPI011050"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011050"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011050-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33938" checksum="33C248C4C18456BC" modified="2016-09-07" version="1">MPNMYREASHAGSWYTDSGAELNRQLNGWLNDADLTFGPARAIIAPHAGYRYCGACGAWAYRQISPAVVKRVFILGPSHHVRLSRCALSAAQYCRTPLYDLKVDQAINKQLESTGHFKWMDQKTDEDEHSIEMHLPYVAKVMEEYSDQFTIIPVMVGSISNEWEETYGKIFAPYLADPQNLFVISSDFCHWGQRFRYTYYEEGSGPIYKWIETLDKMGMDLIETLKADSFSEYLRKYNNTICGRHPIGVLMQAVEELKRRGHRMSFKFLKYDQSNQCCDKKDSSVSYASGSLIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVT7</accession>
    <name>A0A182PVT7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair and recombination protein RAD54-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein okra</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts (via N-terminus) with spn-A/Rad51.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVT7"/>
    <dbReference type="STRING" id="199890.A0A182PVT7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011074-RA">
        <property type="protein sequence ID" value="AEPI011074-PA"/>
        <property type="gene ID" value="AEPI011074"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011074"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18067">
        <property type="entry name" value="DEXHc_RAD54A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="154"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="487"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="737"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="737"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011074-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="785" mass="89381" checksum="B5584F7F3924DFBD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVY7</accession>
    <name>A0A182PVY7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohormone-4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVY7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011124-RA">
        <property type="protein sequence ID" value="AEPI011124-PA"/>
        <property type="gene ID" value="AEPI011124"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011124"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053103">
        <property type="entry name" value="IDLSRF-like_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20967">
        <property type="entry name" value="PROHORMONE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20967:SF0">
        <property type="entry name" value="PROHORMONE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011124-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21678" checksum="BA61A1B61D57B962" modified="2016-09-07" version="1">MAPKSWLWFGNMLFVSFPLAILGIDLSRLYGHMPAVAKRNEACHPYEPFKCPGDGNCISIQYLCDGAPDCSDGYDEDMRLCTAAKRPPVEETASFLQSLLASHGPNYLEKLFGSKARDALAPLGGVEKVAIALSESQTIEDFGAALHLMRSDLEHLRSVFMAVENGDLGMLKSIGIKDSELGDVKFFLEKLVNTGFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVZ8</accession>
    <name>A0A182PVZ8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVZ8"/>
    <dbReference type="STRING" id="199890.A0A182PVZ8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011135-RA">
        <property type="protein sequence ID" value="AEPI011135-PA"/>
        <property type="gene ID" value="AEPI011135"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011135"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF197">
        <property type="entry name" value="FI04477P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="63"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011135-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="250" mass="28321" checksum="6540AA9FE990D941" modified="2016-09-07" version="1">MHPFHDSTITNWMLYLIGIALPVIVIVITELCRARVKKSSETHPLKVWNTDIPFWVVQAYKSIGMFGFGAAVSQLLTDVGKYTIGRLRPHFFDVCKPRMPNGTTCADAINQGRYITDFVCTSEKSSARMLKEMRLSFPSGHSSFSMYTLVFCAIFLHARMNWRGSKLLKHFFQFLLILLAWYTCLSRISDYKHHWSDVLAGAVLGATVAIVVSNFCTDLFSVARKRTMMAATLPQTRYELSPNHTHGNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWC9</accession>
    <name>A0A182PWC9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWC9"/>
    <dbReference type="STRING" id="199890.A0A182PWC9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011266-RA">
        <property type="protein sequence ID" value="AEPI011266-PA"/>
        <property type="gene ID" value="AEPI011266"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011266"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011266-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="265" mass="26523" checksum="007E66A6850C27D5" modified="2016-09-07" version="1">MWEMQALNSQNATSNLTSAHDNALNGGCGNGLTTNGMSISSSGSSCSTGSTGSTTNGTMAANGPLSNGAAGLNGVVTAAQIVPNGVAGLGTGTNPSASVGVASELGVGSSTNNNNNNGSTQASSVVSELAHVTSSLTPMDVNMASANHFVNSIPTSDLEAQTLAFVESANAFLHPALRGVKAVSLARKRPLLGGPRSTMNPTKRTVMTLIARARTAQALHGSRTAQPIGEPIQVITSPLILQPPLDLLQPNASAGVAKENILQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWZ6</accession>
    <name>A0A182PWZ6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PWZ6"/>
    <dbReference type="STRING" id="199890.A0A182PWZ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011483-RA">
        <property type="protein sequence ID" value="AEPI011483-PA"/>
        <property type="gene ID" value="AEPI011483"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011483"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000375">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="39"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011483-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="232" mass="26963" checksum="F48985BD98FEDE84" modified="2016-09-07" version="1">TLNVISNDIFFVVQHLNFLWIRFGVLLEDGRMMQRVGVYDKVEKIGEGTYGVVYKAKDIRNQNNVALKRIRLDNETEGIPSTAMREISLLKDLKHHSIVELFDVVIIETSIYMVFEYLDMDLKKILGCIFAEMILKRPLFPGDSEIDQLFKIFRQMGTPDESKWPGVSHLSDYKESFPYWEPQPLPNEMQHDLDAHTLFCELMHYDPAKRLSPKSAMSHSYFDNVCLVAPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYK6</accession>
    <name>A0A182PYK6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PYK6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014403-RA">
        <property type="protein sequence ID" value="AEPI014403-PA"/>
        <property type="gene ID" value="AEPI014403"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014403"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014403-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="106" mass="11191" checksum="A2D996F06343649B" modified="2016-09-07" version="1">MAMVVSGRAKAVIAAFVCFFLLGIVLVTGSTKGWFVPMRYNERVAARVQLLGGGGKAPLPHSVCEFSVQRPGMNQGRIPTAGQRSQAISASCPACLLKMKALTVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYL1</accession>
    <name>A0A182PYL1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PYL1"/>
    <dbReference type="STRING" id="199890.A0A182PYL1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014407-RA">
        <property type="protein sequence ID" value="AEPI014407-PA"/>
        <property type="gene ID" value="AEPI014407"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014407"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014407-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="105" mass="12722" checksum="C51ED602701C0983" modified="2016-09-07" version="1">MIKPLYTSYQKDLSNTLWEPLNTFWAECYESCKLSSQRRAKLQMESRRKFQVERILVPCRIRQSEENARLSIQQTQRKAKDANTERRWLHLQRFLYGPKGAWARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYX0</accession>
    <name>A0A182PYX0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYX0"/>
    <dbReference type="STRING" id="199890.A0A182PYX0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015038-RA">
        <property type="protein sequence ID" value="AEPI015038-PA"/>
        <property type="gene ID" value="AEPI015038"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015038"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015038-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="508" mass="58737" checksum="9B191C104C0EBB5B" modified="2016-09-07" version="1">MELINAVLAAFIFVVSVAYLFIRNKHNYWKDNAFPYAPNPHFLFGHAKGQAQTRHGADIHQELYRYFKQRGERYGGISQFIVPSVLVLHPELVKTILVKDFNVFHDHGVFNNPKDDPLTGHLFALEGQPWRLMRQKLTPTFTSGRMKQMFGTIWEVGRELEKYMDANYNHPEIEMKDILGRFTTDVIGTCAFGIECNTLKNPDSDFRKYGNKAFELNPVIMMKFFLASSYPGLVRNLRMKITYDDVERFFLDIVKETVDYREANNVKRNDFMNLLLQIKNKGKLDDSEEGVGKGELGMTMNELTAQAFVFFIAGFETSSTTQSFCLYELAKNPNIQERLRQEIERAIEENGGEVTYDVAMNIQYLDNVINETLRKYPPVESLNRVPSNDYLIPGTKHVIPKRTLVQIPVYAIQRDPDHYPDPERFDPDRFLPEEVKKRHPFTFIPFGEGPRICIGLRFGLMQTKVGLISLLRKFRFSPSARTPERVVYDPKMITIAPIAGNYLKVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZB2</accession>
    <name>A0A182PZB2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZB2"/>
    <dbReference type="STRING" id="199890.A0A182PZB2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015177-RA">
        <property type="protein sequence ID" value="AEPI015177-PA"/>
        <property type="gene ID" value="AEPI015177"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015177"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF187">
        <property type="entry name" value="CYTOCHROME P450 4AE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015177-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="510" mass="58773" checksum="FF77FA51F6057A33" modified="2016-09-07" version="1">MIVVLLTTLLGIVVTWMVATIIRNRATVSKLQKQLTNFKVVPSVPLLGSAYHFKDPTPEGIFNTFTGFHQKYGPNLITQSFFNYPSFQVCDPKVIAQVMQARTVEKTIIYDFMKPWLGTGLVVSTGAKWYQRRKLITPTFHFKMLQDFLVIMNLQTDVLIEKLKRNANSKDFDIYEHVTYCALDIISESAMGVKLNTQQQPNSEYVMAVKELSDIILKRLFSFLREYPWAFQFTKAHRRQKELLKIVHDFAYNVISERKKQLQDEREQQLTQQQLEEEDVYGKRRMNMLDLLLNVTIDDKPLSDTDIREEVDTFMFAGHDTTTSCISFAAYYLSQDAVIQQRVYDEIQAVVGPDAKTQMLTSATLQELKYLEMVISETLRMNPSVPIIGRRSAGDMVIDGVTIPKGMDFGILLYALHNDPVENPDPTRFDPERFSDEVYKHRQPYSYIPFSVGARNCIGQRYAMLEVKTMLVKLVANYRLLPCDESNKLRIKTDMTLKPVNGAFVKIVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PKB9</accession>
    <name>A0A240PKB9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PKB9"/>
    <dbReference type="STRING" id="199890.A0A240PKB9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015392-RA">
        <property type="protein sequence ID" value="AEPI015392-PA"/>
        <property type="gene ID" value="AEPI015392"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015392"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012014867" description="Peptidase S1 domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="151"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015392-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="423" mass="47197" checksum="8C52535337C57A01" modified="2017-10-25" version="1">MASLAWWIITTILFTAGIVAQNLVAPSNSEEYCTTNNGEEGICVYQYQCTGGVISDSGENIVDIRHPLDDCNDHLMRCCAKPIDSTSPVSEVDSDQRQDPIVSSSTTALPLPGDQDANDTQQEASRPLVVIPPYEVEGCGHRNPNGVIFAIENNQFSESEYGEYPWTVAIFERTESNSMKYRCGGALIDRAAILTTASCLYSYRLNVSSLVVRLGEWDMSTVREPIPHIDTEMEKIYLHPQYGMTSKINDIAIVILHDTIELTHTIGVVCLPPAGSDPSHADITGVGWGEVPNFVEPRKLPQTILKKAQLHHLSHEQCQQTLRKLMGRRYQLHRSFLCATAQYSEMLPCSGDTGSPYMTETVPGNDRYYLVGLSSWGYDCNRQGTPTVLTNVAYHREWIDKVIKGENLNIWSYTYEQSDNDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PNF0</accession>
    <name>A0A240PNF0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="16">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="16">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PNF0"/>
    <dbReference type="STRING" id="199890.A0A240PNF0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015358-RA">
        <property type="protein sequence ID" value="AEPI015358-PA"/>
        <property type="gene ID" value="AEPI015358"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015358"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000009">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000013">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000003">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000003">
        <property type="entry name" value="Aldehyde oxidase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.120:FF:000007">
        <property type="entry name" value="indole-3-acetaldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000019">
        <property type="entry name" value="indole-3-acetaldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="354"/>
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        </location>
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        <location>
            <position position="2"/>
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            <name>[2Fe-2S] cluster</name>
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            <name>[2Fe-2S] cluster</name>
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            <name>[2Fe-2S] cluster</name>
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            <name>[2Fe-2S] cluster</name>
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            <name>[2Fe-2S] cluster</name>
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            <name>[2Fe-2S] cluster</name>
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            <position position="110"/>
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            <name>[2Fe-2S] cluster</name>
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        <location>
            <position position="344"/>
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            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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            <position position="363"/>
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            <name>FAD</name>
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        <location>
            <position position="709"/>
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            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
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        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
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            <position position="852"/>
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            <name>Mo</name>
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        <location>
            <position position="1004"/>
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            <name>Mo-molybdopterin</name>
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            <name>Mo</name>
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        <source>
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            <dbReference type="PROSITE" id="PS51387"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015358-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1232" mass="135379" checksum="A470A2800EF899C7" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZD5</accession>
    <name>A0A182NZD5_9DIPT</name>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
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            <name>L-ascorbate</name>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
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        <location>
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        </location>
    </feature>
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    </feature>
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        <location>
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    </feature>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51471"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000015-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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    </evidence>
    <sequence length="1490" mass="168113" checksum="721064DDE50868E0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZJ4</accession>
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        <recommendedName>
            <fullName evidence="17">TIR domain-containing protein</fullName>
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    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182NZJ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000075-RA">
        <property type="protein sequence ID" value="AEPI000075-PA"/>
        <property type="gene ID" value="AEPI000075"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000075"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010556">
        <property type="term" value="P:regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000355">
        <property type="entry name" value="Toll-like receptor Tollo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130618" description="TIR domain-containing protein" evidence="16">
        <location>
            <begin position="21"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1026"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="17">
        <location>
            <begin position="1084"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1279"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1282"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000075-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1345" mass="150796" checksum="8D5509EA3280DB62" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZL4</accession>
    <name>A0A182NZL4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein takeout</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZL4"/>
    <dbReference type="STRING" id="199890.A0A182NZL4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000095-RA">
        <property type="protein sequence ID" value="AEPI000095-PA"/>
        <property type="gene ID" value="AEPI000095"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000095"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000095-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="29209" checksum="510D6EF8DEA913A2" modified="2016-09-07" version="1">MVAHTWYYGLAGIWFLSLGIAIEGKDLPSSFEKCHRNDPQFDQCLRSAVNGAIRLLKDGLPEFGILPLEPLAVDSLVIEQGEPSSPIKLKQHFTNVRLSHLTESTILKYRTDLKKLIIKAEAITPQIQFAGNYTMDGRILVLPITGKGLANITLHRLKTHHELIGELVERNGEQYMHIRKYLVHFEPKLVTFQFGNLFNGDERLSKTMHQVLNDNWEVVFRELRSSYEDTFGYIFKKISNQIFLKVPMNKIFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZR5</accession>
    <name>A0A182NZR5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZR5"/>
    <dbReference type="STRING" id="199890.A0A182NZR5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000146-RA">
        <property type="protein sequence ID" value="AEPI000146-PA"/>
        <property type="gene ID" value="AEPI000146"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000146"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000554">
        <property type="entry name" value="Anaphase-promoting complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000052">
        <property type="entry name" value="Anaphase-promoting complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014786">
        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="472"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000146-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="790" mass="91179" checksum="039FB08D4A660701" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P024</accession>
    <name>A0A182P024_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phospholipase A2</fullName>
            <ecNumber evidence="3">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphatidylcholine 2-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P024"/>
    <dbReference type="STRING" id="199890.A0A182P024"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000256-RA">
        <property type="protein sequence ID" value="AEPI000256-PA"/>
        <property type="gene ID" value="AEPI000256"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000256"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Phospholipase A2-like central" evidence="8">
        <location>
            <begin position="198"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="8">
        <location>
            <begin position="271"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000256-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="335" mass="39058" checksum="C6B57704E5597186" modified="2016-09-07" version="1">MSSSTNKTLHLWQMGTHKYLIQIIYNGEGQMMDCEYVRQRGMVHQFRNRFYSEYFQARARNFSSAFDAGRNGDMGRGSLVSDHDFREFLEHDVVTPEMEELQYNVYEFPAGVPASQQTIDAFGMRNLTYIPLRASTDIPAELLEQLNFHQLKQRCNVRHMQLKEIATGLRSADPEHKRIANEKLQRHKRAISDWFLSPNTKWCGKGHSASEYRQLGGASRADMCCRTHDHCKYMIPPMSTNFQTFNFRPFTISHCACDTRQRRDLSSMMRVPGTKWCGKGWSARNYVDMGGYSKADRCCRQHDLSCPFWILGFETKYNLFNWRVGTLMHCGCDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P097</accession>
    <name>A0A182P097_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182P097"/>
    <dbReference type="STRING" id="199890.A0A182P097"/>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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            <taxon>Pterygota</taxon>
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            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
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            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="29"/>
        </location>
    </feature>
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            <begin position="30"/>
            <end position="1118"/>
        </location>
    </feature>
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        <location>
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            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
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        </location>
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            <end position="997"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000333-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0J1</accession>
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        <recommendedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Gargeya S."/>
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                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0J1"/>
    <dbReference type="STRING" id="199890.A0A182P0J1"/>
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        <property type="gene ID" value="AEPI000423"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000423"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000423-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="157" mass="17986" checksum="2D5C57FC1F3B5CDA" modified="2016-09-07" version="1">MAGRESGRIREADKKRTLDDAARQRRARKALEALEQDNFHEDPHADLVMSKKVPKFSDNLDGSGPSKKKNRRTKGAEYYRAKYRKTFPQLLDEERQQRPDPPNYFSAAAPPSRLPERHFCAVCGFPSSYTCTACGTRYCCVRCLGTHQDTRCLKWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0N8</accession>
    <name>A0A182P0N8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0N8"/>
    <dbReference type="STRING" id="199890.A0A182P0N8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000470-RA">
        <property type="protein sequence ID" value="AEPI000470-PA"/>
        <property type="gene ID" value="AEPI000470"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000470"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08718">
        <property type="entry name" value="RGS_RZ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000015">
        <property type="entry name" value="Regulator of G-protein signaling 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RGS" evidence="10">
        <location>
            <begin position="62"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000470-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="196" mass="22509" checksum="9860CC8DDD7BAE12" modified="2016-09-07" version="1">MAPGDRENSKGQQQQQQQQKGRRLAIKNAEDNGPTKKDQASSDTLFDGEQPTLEEIRSWGKSFDKLMRSPSGRKAFREFLRCEYSEENILFWLACEELKKETNPEAIEEKARFIYEDYISILSPKEVSLDSRVREIVNRNMVEPTPHTFDEAQLQIYTLMHRDSYPRFINSPQFKTLAQIPEGVSASGSTAESPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0X0</accession>
    <name>A0A182P0X0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0X0"/>
    <dbReference type="STRING" id="199890.A0A182P0X0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000552-RA">
        <property type="protein sequence ID" value="AEPI000552-PA"/>
        <property type="gene ID" value="AEPI000552"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000552"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF9">
        <property type="entry name" value="DUF229 DOMAIN CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000552-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="803" mass="90763" checksum="361AC579042249C6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0X9</accession>
    <name>A0A182P0X9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0X9"/>
    <dbReference type="STRING" id="199890.A0A182P0X9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000561-RA">
        <property type="protein sequence ID" value="AEPI000561-PA"/>
        <property type="gene ID" value="AEPI000561"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000561"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000006">
        <property type="entry name" value="Cytochrome P450 302a1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000561-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="571" mass="65595" checksum="353DC0281DE5783B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P171</accession>
    <name>A0A182P171_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P171"/>
    <dbReference type="STRING" id="199890.A0A182P171"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000653-RA">
        <property type="protein sequence ID" value="AEPI000653-PA"/>
        <property type="gene ID" value="AEPI000653"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000653"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000077">
        <property type="entry name" value="Sp8 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF170">
        <property type="entry name" value="FI01014P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="501"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="573"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="651"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="729"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="586"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="738"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="786"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000653-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="851" mass="89606" checksum="ACC2A9C5117FCCCD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1M6</accession>
    <name>A0A182P1M6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P1M6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000808-RA">
        <property type="protein sequence ID" value="AEPI000808-PA"/>
        <property type="gene ID" value="AEPI000808"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000808"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DNA repair endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
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    </dbReference>
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        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="16">
        <location>
            <begin position="989"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="135"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="460"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="765"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="872"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="909"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1240"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1291"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="306"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1363"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000808-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1452" mass="161228" checksum="C72BBDF134B50F48" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P222</accession>
    <name>A0A182P222_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AEPI000956"/>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057847">
        <property type="entry name" value="ZMIZ1/ZMIZ2_GBD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25527">
        <property type="entry name" value="GBD-like_ZMIZ1_ZMIZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="633"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="739"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="879"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="942"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1154"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="756"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="891"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="982"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1036"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1165"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000956-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1183" mass="124092" checksum="D6357D29406D90F3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P280</accession>
    <name>A0A182P280_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-ketoacyl-[acyl-carrier-protein] synthase I</fullName>
            <ecNumber evidence="2">2.3.1.41</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182P280"/>
    <dbReference type="STRING" id="199890.A0A182P280"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001014-RA">
        <property type="protein sequence ID" value="AEPI001014-PA"/>
        <property type="gene ID" value="AEPI001014"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001014"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001014-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="352" mass="37069" checksum="F1752CF797944C30" modified="2016-09-07" version="1">MARATAFALIAAKEALSMARWMPAIEDEAACQRTGVAIGMGMVDLMDICETNEALKKGYNRVSPFFVPRILPNMPAGQLSIRYGFRGPNHAVSTACATGAHAIGDAFRFIQHGDAEVMVCGGAEACISPLGIAGFCRLRALSTAFNDEPMASSRPFDKRRDGFVMGEGSAIFVLEELDHAKQRGAQIYGEILGYGLSGDASHLTAPREDGTGALLAMQRALGDAGVTVADIGYVNAHATSTPIGDAIEARSIRTLFGEHAGSVAVSSTKGAHGHLLGAAGNLEAMFVVMACKNGMLPPTVNLQNVTDDMAGLHYVANSSEHWEGNGRRRIALKNSFGFGGTNASLCIGEYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2E7</accession>
    <name>A0A182P2E7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2E7"/>
    <dbReference type="STRING" id="199890.A0A182P2E7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001081-RA">
        <property type="protein sequence ID" value="AEPI001081-PA"/>
        <property type="gene ID" value="AEPI001081"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001081"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001081-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="119" mass="13509" checksum="74DB36871C8922AF" modified="2016-09-07" version="1">MAAMGRKLLNNLKSKEFREYLMSTHFWGPVANWGIPIAALGDLKKDPKIISGTMTTALCLYSLIFMRFAWKVQPRNMLLFACHVTNFTAQGMQGARFIEYHHMGGKERMQKAQVQQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2L9</accession>
    <name>A0A182P2L9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">26S proteasome non-ATPase regulatory subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2L9"/>
    <dbReference type="STRING" id="199890.A0A182P2L9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001153-RA">
        <property type="protein sequence ID" value="AEPI001153-PA"/>
        <property type="gene ID" value="AEPI001153"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001153"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="7">
        <location>
            <begin position="792"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="844"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1016"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="848"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="912"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="935"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001153-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1037" mass="112747" checksum="CD0CE2CD2A2C0042" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2R1</accession>
    <name>A0A182P2R1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2R1"/>
    <dbReference type="STRING" id="199890.A0A182P2R1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001195-RA">
        <property type="protein sequence ID" value="AEPI001195-PA"/>
        <property type="gene ID" value="AEPI001195"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001195"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001195-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="70" mass="7945" checksum="25DDFF0EA981AB17" modified="2016-09-07" version="1">MTHNIYTDWANYYLERAKSKKKVSDLSADCRDGLLLAEVIEAVTTFKVPDLVKKPKTAQHMMSGMISKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P338</accession>
    <name>A0A182P338_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P338"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001322-RA">
        <property type="protein sequence ID" value="AEPI001322-PA"/>
        <property type="gene ID" value="AEPI001322"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001322"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001322-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="274" mass="28738" checksum="CE804AD57ED7A00F" modified="2016-09-07" version="1">MACKWVSQGGGQGVNSPLMGAFLTMAGSRHDRLQPAAVVQSLYRANVACAAVSGLLVVCCLAALGYIVVKYEKRRHNLLALHNLRSAVLLVALLVGIGEIGHQWLAVDRLGRVRAADGCTGTMRPEVHSTQSEAFTTDRPPFGDGDALAWKTVTAGLGAAWLALLALLGVACVVRAIERRDKCGLLYAVLAAEGAQSIVRWCKFKYINDVTDTGSRPGSTSSPLGSGSSILGTPELFLALVGALAATTLTAIDGFTLYVEVSVRDFPTVVSVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P399</accession>
    <name>A0A182P399_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P399"/>
    <dbReference type="STRING" id="199890.A0A182P399"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001383-RA">
        <property type="protein sequence ID" value="AEPI001383-PA"/>
        <property type="gene ID" value="AEPI001383"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001383"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06685">
        <property type="entry name" value="PDZ7_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000035">
        <property type="entry name" value="Glutamate receptor interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000206">
        <property type="entry name" value="Glutamate receptor-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000246">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043545">
        <property type="entry name" value="GRIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227:SF2">
        <property type="entry name" value="FI03335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227">
        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="116"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="212"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="378"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="484"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="734"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="862"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001383-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="947" mass="102482" checksum="CD123F2E1D4D1A7D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P486</accession>
    <name>A0A182P486_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MANSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P486"/>
    <dbReference type="STRING" id="199890.A0A182P486"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001722-RA">
        <property type="protein sequence ID" value="AEPI001722-PA"/>
        <property type="gene ID" value="AEPI001722"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001722"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001655">
        <property type="entry name" value="Blast:Dyslexia-associated protein KIAA0319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000061">
        <property type="entry name" value="Dyslexia-associated protein KIAA0319 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000257">
        <property type="entry name" value="Dyslexia-associated protein KIAA0319-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029865">
        <property type="entry name" value="KIAA0319-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013980">
        <property type="entry name" value="MANSC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011106">
        <property type="entry name" value="MANSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182:SF2">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22352">
        <property type="entry name" value="K319L-like_PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23597">
        <property type="entry name" value="KIAA0319_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00765">
        <property type="entry name" value="MANEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50986">
        <property type="entry name" value="MANSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130772" description="MANSC domain-containing protein" evidence="11">
        <location>
            <begin position="27"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="MANSC" evidence="12">
        <location>
            <begin position="48"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1069"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001722-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1108" mass="122024" checksum="2A5C842F5A3B6D8C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4H5</accession>
    <name>A0A182P4H5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4H5"/>
    <dbReference type="STRING" id="199890.A0A182P4H5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001811-RA">
        <property type="protein sequence ID" value="AEPI001811-PA"/>
        <property type="gene ID" value="AEPI001811"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001811"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11057">
        <property type="entry name" value="CYP313-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001811-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="508" mass="58420" checksum="6A2138546CF233EB" modified="2016-09-07" version="1">MTGLAVFVTTLGLFVLWWTVWRLRRWKHLKLSADLNGPPDFPLIGSAHLFLGKSTEQQFQCILDITTTYQSPCRVWLGPKLFVFIDNADDLQTVLNASQCLEKAHVYRFFQCETGLFSAPAPIWKVHRKHLNPCFNAKILASFMSVFNAKSAIMVDQLQRRVNQPKQFNVYEYISKCTLDMVCATTLGTNMQLQNEQGDEYIAAIERASELLNHRLYKVWLHPEWIYRLTSYYKVQQQCYATAYKMSRRVLALRGDELSEIRNRSTVPVEKPNSSQPVDEYRKPQIYIDQLFRLAKETGVFDERAIRDEIDTIILGGNETSALTLSHVVLMLAIHQDVQQRVYEELVATLGSSFTEVENDQLSRLPYMEMVLKETMRLFPVGPVIARQCTDDLKISNAIIPNGVTVVLGIFNVQRSGKHWGPAADTFDPDNFLPERSTHRHPYCFLPFSAGPRNCIGYKYGLMSMKVMLCRLLAAFRFSTDLTMEQLVLKLDITLKIDNKHMVRIVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4P2</accession>
    <name>A0A182P4P2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182P4P2"/>
    <dbReference type="STRING" id="199890.A0A182P4P2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001878-RA">
        <property type="protein sequence ID" value="AEPI001878-PA"/>
        <property type="gene ID" value="AEPI001878"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001878"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="482"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="670"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="52"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="425"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001878-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1158" mass="132515" checksum="4FFCE93B89E57AA1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5C9</accession>
    <name>A0A182P5C9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polyadenylate-binding protein</fullName>
            <shortName evidence="5">PABP</shortName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5C9"/>
    <dbReference type="STRING" id="199890.A0A182P5C9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002119-RA">
        <property type="protein sequence ID" value="AEPI002119-PA"/>
        <property type="gene ID" value="AEPI002119"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002119"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000010">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000021">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000042">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000049">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="99"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="192"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="295"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="7">
        <location>
            <begin position="560"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002119-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="643" mass="71590" checksum="E7FE6BE0D2561219" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5P8</accession>
    <name>A0A182P5P8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-fucose protein O-fucosyltransferase 1</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peptide-O-fucosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 65 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182P5P8"/>
    <dbReference type="STRING" id="199890.A0A182P5P8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002239-RA">
        <property type="protein sequence ID" value="AEPI002239-PA"/>
        <property type="gene ID" value="AEPI002239"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002239"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11302">
        <property type="entry name" value="O-FucT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039922">
        <property type="entry name" value="POFUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420:SF10">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130838" description="GDP-fucose protein O-fucosyltransferase 1" evidence="17">
        <location>
            <begin position="18"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002239-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="398" mass="45476" checksum="C2E408F712BC0977" modified="2016-09-07" version="1">MFRSVGYLVALLGFVQSITVDKNGYIMYCPCMGRFGNQADHFLGSFGFAKALNRTLVLPPWVEYRKGEIRSIQVPFDTYFQVGPLQAFHRVITMENFMRNLAPSLWPPEERISFCYTERMGLDGSTGHGCNAKSGNPFGPFWDTFKVDFARSEFFGPKLNYDIHHGQHMARQWYERYPGDKWPVLAFTGAPAVFPVQAENLPLHRYLRWSVKYESEAKQFIRDSLPRGAFIGIHLRNGIDWVRACEHVKESANLFSSPQCLGYRNEHGQLTVDMCLPTKDTIIRQLKRQIKLHREASPDNPIRAVFVASDSNHMLGELNDALKRMDITVVRHPDSNPHLDLAILGRSNHFIGNCISSYSAFVKRERDSNGFPSSFWAFPPEKPGSKAKDANLLQHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P661</accession>
    <name>A0A182P661_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P661"/>
    <dbReference type="STRING" id="199890.A0A182P661"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002409-RA">
        <property type="protein sequence ID" value="AEPI002409-PA"/>
        <property type="gene ID" value="AEPI002409"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002409"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000079">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF1">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002409-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="185" mass="21280" checksum="C9100F793F280BEF" modified="2016-09-07" version="1">MGQVKSQFSEDELQDYEDLTYFTKKEILYAHKKFKNLAPEKVGHNKNAKLSMSKVLEYPELKANPFGDRICKVFSSSNDGDITFEDFLDMMSVFSDAAPKSVKAEHAFRIYDFDGDDMIGRNDLKQVIQRLIDYNSDLGHNDIDQLINNILEEADLDDDGALSFAEFEHIIDKSSDFINSFRIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6B4</accession>
    <name>A0A182P6B4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6B4"/>
    <dbReference type="STRING" id="199890.A0A182P6B4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002462-RA">
        <property type="protein sequence ID" value="AEPI002462-PA"/>
        <property type="gene ID" value="AEPI002462"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002462"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002462-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="114" mass="12918" checksum="685155B1C8B4D7BB" modified="2016-09-07" version="1">MDIKSLSEVQKQIFTNLIEKLIARNKFPPSEAEDVQKLLENVRDAKNFHKIMEKLKECGQLDVDIEENFREENGIFLKDTAKKLGPGGQTLTPRHTIDAILGLNNCENGGRILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6I6</accession>
    <name>A0A182P6I6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6I6"/>
    <dbReference type="STRING" id="199890.A0A182P6I6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002534-RA">
        <property type="protein sequence ID" value="AEPI002534-PA"/>
        <property type="gene ID" value="AEPI002534"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002534"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16470">
        <property type="entry name" value="RING-H2_RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23818">
        <property type="entry name" value="RWD_RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000215">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039133">
        <property type="entry name" value="RNF25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13198:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13198">
        <property type="entry name" value="RING FINGER PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002534-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="384" mass="42308" checksum="FD7416D1E4B29FAB" modified="2016-09-07" version="1">MDDVHITKNASGFPELIETIVFPTVGEEVESQYVCITLQVLPTVGYPDVRPNVKLRNPRGLDDSIIGQIERAVQQKLTESIGQPVVFDLIDIIREHLTESNLPSGQCVICLYGFLEGDEFTKTVCYHYLHSHCLACHINASKRNYEEEIEKLPIWKRKEAKPFQAQCPVCREPIDVEVEPLMRCRPPTERENAPKFKVTDELKSLQAQMNRLFMHQKRRGGIIDLEAEEGNVIAIETESPNGEISTKGTNDTPNSPGSGTPEVKPSGNNHSASKKHGANAQQHTKGSSSSKGARQRNNAQPVNGEANEDPDACTGPCCTGQNDHHRGRNRRHNNHHHHHHSNRHQRHLHQHTHRGSGAGGAAGPSTAAGGAAKNLATPCGSDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7A9</accession>
    <name>A0A182P7A9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7A9"/>
    <dbReference type="STRING" id="199890.A0A182P7A9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002811-RA">
        <property type="protein sequence ID" value="AEPI002811-PA"/>
        <property type="gene ID" value="AEPI002811"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002811"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000133">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002811-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="274" mass="29752" checksum="656D263D3D8649E1" modified="2016-09-07" version="1">MADAAPARGGFRGGFGSRGGARGGGRGGRGRGRGRGRGRGGKEDSKEWVPVTKLGRLVKDGKIRTLEEIYLYSLPIKEFEIIDFFLNRLLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDSNGHIGLGVKCSKEVATAIRGAIILAKLSVVPVRRGYWGNKIGRPHTVPCKVSGKCGSVLVRLIPAPRGTGIVSAPVPKKLLQMAGIDDCYTTTRGSTTTLGNFAKATYAAIAKTYVFLTPDLWKDLPLNKTPYQEFADFLDKTSKTGQRIIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7F1</accession>
    <name>A0A182P7F1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Stress-activated protein kinase JNK</fullName>
            <ecNumber evidence="11">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182P7F1"/>
    <dbReference type="STRING" id="199890.A0A182P7F1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002853-RA">
        <property type="protein sequence ID" value="AEPI002853-PA"/>
        <property type="gene ID" value="AEPI002853"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002853"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036477">
        <property type="term" value="C:somatodendritic compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903034">
        <property type="term" value="P:regulation of response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07850">
        <property type="entry name" value="STKc_JNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000009">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000210">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008351">
        <property type="entry name" value="MAPK_JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01772">
        <property type="entry name" value="JNKMAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002853-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="376" mass="43416" checksum="16393A031B0E5A72" modified="2016-09-07" version="1">MSRRSTNYVRYQFGDTEFEVPERYIKLEAKGFGAQGTVCAAYDTVTQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRTLEEFQDVYLVMELMDANLCQVIQMDLDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSQSFMARLQPTVRNYVENRPRYTGYPFDRLFPDVLFPTDSNEHNRLKASQARDLLSRMLVVDPEHRISVDQALVHSYINVWFDESEVNAPAPGPYDHSVDEREHTVEQWKELIYQEVMEYEARNNPADGEGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7P6</accession>
    <name>A0A182P7P6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P7P6"/>
    <dbReference type="STRING" id="199890.A0A182P7P6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002949-RA">
        <property type="protein sequence ID" value="AEPI002949-PA"/>
        <property type="gene ID" value="AEPI002949"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002949"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000103">
        <property type="entry name" value="Phosphatase 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000116">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="154"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="696"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="451"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="697"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="723"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002949-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="790" mass="82444" checksum="E030FE076139B44C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7Z1</accession>
    <name>A0A182P7Z1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipase maturation factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the maturation of specific proteins in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lipase maturation factor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7Z1"/>
    <dbReference type="STRING" id="199890.A0A182P7Z1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003044-RA">
        <property type="protein sequence ID" value="AEPI003044-PA"/>
        <property type="gene ID" value="AEPI003044"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003044"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009613">
        <property type="entry name" value="LMF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057433">
        <property type="entry name" value="LMF1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057434">
        <property type="entry name" value="LMF1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463">
        <property type="entry name" value="LIPASE MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463:SF5">
        <property type="entry name" value="LIPASE MATURATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06762">
        <property type="entry name" value="LMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25179">
        <property type="entry name" value="LMF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase maturation factor 1/2 N-terminal" evidence="9">
        <location>
            <begin position="97"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase maturation factor 1/2 C-terminal" evidence="10">
        <location>
            <begin position="423"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003044-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="636" mass="72733" checksum="65C40CDB14131BB3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8N4</accession>
    <name>A0A182P8N4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8N4"/>
    <dbReference type="STRING" id="199890.A0A182P8N4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003287-RA">
        <property type="protein sequence ID" value="AEPI003287-PA"/>
        <property type="gene ID" value="AEPI003287"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003287"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13435">
        <property type="entry name" value="SPFH_SLP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131057" description="Band 7 domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="9">
        <location>
            <begin position="49"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003287-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="328" mass="35624" checksum="27C1F1C6CC23CA0E" modified="2016-09-07" version="1">MFILGYFSSLALPFFQPTAEADSIGCVEVLATVCSIVLMVLTLPISLFLCFKVVQEYERAVIFRLGRLRSGGARGPGVFFVLPCIDNYCKVDLRTVSFDVPPQEVLTRDSVTVSVDAVVYYRIRDPLNAVVQVANYSHSTRLLAATTLRNVLGTRNLSELLTEREAISHSMQVTLDEATDPWGVQVERVEIKDVSLPDSLQRSMAAEAEAAREARAKVIAAEGEMKSSRALKEASDIMCESPAALQLRYLQTLSSIAGEKNSTIVFPLPIELIGPLMNFTSSLGVQRTFAPMQPPTTGPPNAGGGPSTTTSLSSPLADMGHQQQQLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P922</accession>
    <name>A0A182P922_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P922"/>
    <dbReference type="STRING" id="199890.A0A182P922"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003426-RA">
        <property type="protein sequence ID" value="AEPI003426-PA"/>
        <property type="gene ID" value="AEPI003426"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003426"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000012">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000016">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000022">
        <property type="entry name" value="Cullin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="411"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003426-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="765" mass="89522" checksum="4E23B32F1A8FC508" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9K0</accession>
    <name>A0A182P9K0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bicaudal D-related protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P9K0"/>
    <dbReference type="STRING" id="199890.A0A182P9K0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003605-RA">
        <property type="protein sequence ID" value="AEPI003605-PA"/>
        <property type="gene ID" value="AEPI003605"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003605"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051149">
        <property type="entry name" value="Spindly/BICDR_Dynein_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123:SF13">
        <property type="entry name" value="BICAUDAL D-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123">
        <property type="entry name" value="BICD FAMILY-LIKE CARGO ADAPTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="25"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="390"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003605-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="55775" checksum="15149A868E628B42" modified="2016-09-07" version="1">MNLEQEKYILKRQLEISSSENEAIILELQGDIKQFRQKLEAQEQIMRQMEREKNMLIEELTAQNTRLSNELQKSNATEQQLTAQLQEIKEQCNRRTLSIQDHVNSLESLKNELRLILEKKNELENRLHMTVNERENLSIALNEASERIHILERSTKEQDTKYQMTVQTLDRLERENGTLSERLESFDSQRSLHGELQHHSSLLQEMNGEEEVTGSKDEASHLVLKEAQSVYKQLKTLCQTLRSTHHDDDSGLHSDMSFSSLDNTMASVSMAAPNSVTEATSASMTVNDKFSRGMLSAVADELVHTIMNLDAMQFKTMFEQTRSMLIEQEEELKKKNDVIMQLESKLSVREVELQSTIEERNQAREDASHSSLAQDETVVQARKDRDAAIERRTKAEVELAKNRVELMQANSQLLEAIQQKVELLQQLEQWQIDMHELIEEQMKNKLIESSTKPQTHQQQSQQSSGASTAGSRKSRLLDLFYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA99</accession>
    <name>A0A182PA99_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4200 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PA99"/>
    <dbReference type="STRING" id="199890.A0A182PA99"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003853-RA">
        <property type="protein sequence ID" value="AEPI003853-PA"/>
        <property type="gene ID" value="AEPI003853"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003853"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051650">
        <property type="term" value="P:establishment of vesicle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DUF4200" evidence="4">
        <location>
            <begin position="673"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003853-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="959" mass="110244" checksum="E3A8C6DAB5ABF1FD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAA0</accession>
    <name>A0A182PAA0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding factor A, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAA0"/>
    <dbReference type="STRING" id="199890.A0A182PAA0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003854-RA">
        <property type="protein sequence ID" value="AEPI003854-PA"/>
        <property type="gene ID" value="AEPI003854"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003854"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039212">
        <property type="entry name" value="RBFA_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14725">
        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14725:SF0">
        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="Ribosome-binding factor A, RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003854-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29736" checksum="6294BBBDD347827D" modified="2016-09-07" version="1">MIKIVSTRLFSASSQLRGSSTKAAKVLNKLMNGSKTKKKRYYDETNDSGPKLMPTKSLASTSRQGKESNRRVAVLNKLFMKNITDLMATGSFASDLYGYGIQISRVRVAPDFREASIYWFSTNLNKDVKIDGILKPLCSRLRHELSQLRLMGEVPQLTFVLDKRYYVEGLLNSLLKEADYGEDAVDGNVDEDAMTKLEDQRLCEPEMRHDILGLDHAQIMSRIRQSVDKTNKAWKLHQEAQKKRDADAALQRTSLEQLGKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAI5</accession>
    <name>A0A182PAI5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Integrin alpha second immunoglobulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAI5"/>
    <dbReference type="STRING" id="199890.A0A182PAI5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003939-RA">
        <property type="protein sequence ID" value="AEPI003939-PA"/>
        <property type="gene ID" value="AEPI003939"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003939"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF83">
        <property type="entry name" value="INTEGRIN ALPHA-PS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007950983" description="Integrin alpha second immunoglobulin-like domain-containing protein" evidence="13">
        <location>
            <begin position="27"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1078"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="114"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="192"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="338"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="401"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="462"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="15">
        <location>
            <begin position="652"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1116"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1122"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003939-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1141" mass="126810" checksum="64F923432AE39FD8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAL1</accession>
    <name>A0A182PAL1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAL1"/>
    <dbReference type="STRING" id="199890.A0A182PAL1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003966-RA">
        <property type="protein sequence ID" value="AEPI003966-PA"/>
        <property type="gene ID" value="AEPI003966"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003966"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF93">
        <property type="entry name" value="RESTIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003966-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="318" mass="33751" checksum="62F309131D7FF4FC" modified="2016-09-07" version="1">MGRMCDVDEESETDLAFERPISARSSHSPDSGFKSNRSDRKTSSASTGSDVYWEATGRRRSSDQGAVLTTDTDSFIIGQRVWVGGIRPGQIAYIGETHFAPGEWAGVVLDEPNGKNDGSVAGKRYFQCEPKKGVFSRLTRLTREPLANAGAGDSTASTPLDASFRSLTSPARSGTVSPTHSVQSYASKSPAMAGKAASLNVGDRVIVSSGFGSRPGVLKFIGETQFASGTWCGVQLDEASGKNDGTVEGVRYFECPAKYGIFVPIAKVTLSPSARKSSAWLSRANSKESLNSMATMSSIATTATSRLRMSAQVSLTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAV0</accession>
    <name>A0A182PAV0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAV0"/>
    <dbReference type="STRING" id="199890.A0A182PAV0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004055-RA">
        <property type="protein sequence ID" value="AEPI004055-PA"/>
        <property type="gene ID" value="AEPI004055"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004055"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000003">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0140">cGMP</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="56"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="138"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004055-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="382" mass="44480" checksum="B031AECE4E7C0A76" modified="2016-09-07" version="1">MLNGFHFDKCDEEVATAFSVYCGISIMHALVHKQVQKAEARYKLSQELLLYHMKVPDVEVNHALEAVKEPDREQDELYRTFPRFDFCPRDVKDHALSVQLAMRMFYDLNFVGSFKIHEYKLARFVLLVQKGYRDTPYHNWWHAFSVAHFAYTLMMNLRLIERGIITKMQGFSFLIAAFCHDLDHRGISNSYQTQTSSPLARLYSSEGSVNERHHLSQAICILNDSSSKILDGLSTTEFKECIDYLRELILATDLANHFRILPRLKKLRAEYLTEGSNQRLLLSLMITCCDLNDQIKSWKTVQHVAHLVYAEFFAEGDLEKQMGLRPNAMMDRKKACIPMLQIEFLTTVIRPTFEILVQIFPETSSFLDTIDSNREQWERVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCA2</accession>
    <name>A0A182PCA2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCA2"/>
    <dbReference type="STRING" id="199890.A0A182PCA2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004557-RA">
        <property type="protein sequence ID" value="AEPI004557-PA"/>
        <property type="gene ID" value="AEPI004557"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004557"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016422">
        <property type="term" value="F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000082">
        <property type="entry name" value="Phosphorylated CTD-interacting factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039881">
        <property type="entry name" value="PCIF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022035">
        <property type="entry name" value="PCIF1_WW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727:SF0">
        <property type="entry name" value="MRNA (2'-O-METHYLADENOSINE-N(6)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727">
        <property type="entry name" value="PHOSPHORYLATED CTD INTERACTING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12237">
        <property type="entry name" value="PCIF1_WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004557-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="782" mass="87784" checksum="6DE014564FD9BD7F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCN3</accession>
    <name>A0A182PCN3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCN3"/>
    <dbReference type="STRING" id="199890.A0A182PCN3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004688-RA">
        <property type="protein sequence ID" value="AEPI004688-PA"/>
        <property type="gene ID" value="AEPI004688"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004688"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035248">
        <property type="term" value="F:alpha-1,4-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007652">
        <property type="entry name" value="A1-4-GlycosylTfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04572">
        <property type="entry name" value="Gb3_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha 1,4-glycosyltransferase" evidence="8">
        <location>
            <begin position="228"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha 1,4-glycosyltransferase" evidence="8">
        <location>
            <begin position="510"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004688-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="639" mass="73654" checksum="22870B275FD03716" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCR9</accession>
    <name>A0A182PCR9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCR9"/>
    <dbReference type="STRING" id="199890.A0A182PCR9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004724-RA">
        <property type="protein sequence ID" value="AEPI004724-PA"/>
        <property type="gene ID" value="AEPI004724"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004724"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004724-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="317" mass="35779" checksum="B65765D51CB42206" modified="2016-09-07" version="1">MAFRTQKKNCGICGEKRPICHPNLLAVKTKFSSTTVAQLLERFAERELSDLGTELEQSGTCKDCYTKLNDYDAAYTKALIIQQELTDLLQNSGLRIFDEEQILAEEVEAENVEMKWEQMEEIEQPDDTNPTKLISIESLQAVQFCMELNVCGEGFGNISDAQWHTHDEESDDEQLDAPVKESGNPSPMLVIEAIEQPEQILVNEGLAACDGTISTTYTEGENDPRCIKTEEHIEESHPIVEGYVCKTHSGERPFACPVCGQLFSQRYNMVQHLNAHNGAPKRSIKVLECPYCDRTCDRKTQLKKHLEKCHPDKPVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDG8</accession>
    <name>A0A182PDG8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDG8"/>
    <dbReference type="STRING" id="199890.A0A182PDG8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004973-RA">
        <property type="protein sequence ID" value="AEPI004973-PA"/>
        <property type="gene ID" value="AEPI004973"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004973"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000166">
        <property type="entry name" value="homeobox protein Hox-C11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046333">
        <property type="entry name" value="HXA10/ABDB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004973-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="134" mass="15241" checksum="AA9E09925611C2A3" modified="2016-09-07" version="1">SSLSVGVSGVGSCTPSNPLEWTGNVTVRKKRKPYSKFQTLELEKEFLFNAYVSKQKRWELARNLNLTERQVKIWFQNRRMKNKKNSQRQSAQANSSSSNNSSSHSHSQPHGHHNSHHISLGLGMSTLHSSKMHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE23</accession>
    <name>A0A182PE23_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Ras-related protein Rab-30</fullName>
            <ecNumber evidence="8">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins. Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner. Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">Autophagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A182PE23"/>
    <dbReference type="STRING" id="199890.A0A182PE23"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005178-RA">
        <property type="protein sequence ID" value="AEPI005178-PA"/>
        <property type="gene ID" value="AEPI005178"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005178"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000440">
        <property type="entry name" value="Ras-related protein Rab-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0636">Prenylation</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00093384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005178-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="237" mass="26535" checksum="598B8E57E55249DE" modified="2016-09-07" version="1">MEDYKFLFKVVLVGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEVDNQKIKLQIWDTAGQERFRSITQSYYRSASALILVYDISCQPTFDCLPDWLREIQEHANSKVLKILVGNKTDRDDREIPQEVGAEFAKQHGMYFLETSAKQADNVERLFYDIAAVLIEQARTKEFTLRSETSVLTNLSQKTIYHPSCCSIGDRNHARSSSTSDAHYSDSSGPASIGSNSGNFITQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE59</accession>
    <name>A0A182PE59_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PE59"/>
    <dbReference type="STRING" id="199890.A0A182PE59"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005214-RA">
        <property type="protein sequence ID" value="AEPI005214-PA"/>
        <property type="gene ID" value="AEPI005214"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005214"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005214-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="143" mass="16265" checksum="AF1559508236CF31" modified="2016-09-07" version="1">MSINDDLNQGQQLPVDLEPEFEGTIQNISSPTGREAILTCSVKNLGRYKVGWLRASDQTVLALEGRVVTHNSRISVVHEDFRTWRLRIRQLRESDRGCYMCQINASPMKKQIGCIDVQGKFRVVPHFPTARDTLNSTRTHLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEA4</accession>
    <name>A0A182PEA4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEA4"/>
    <dbReference type="STRING" id="199890.A0A182PEA4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005259-RA">
        <property type="protein sequence ID" value="AEPI005259-PA"/>
        <property type="gene ID" value="AEPI005259"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005259"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01735">
        <property type="entry name" value="LSm12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048478">
        <property type="entry name" value="LSM12_LSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21166">
        <property type="entry name" value="LSM12_LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005259-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="188" mass="20636" checksum="35575B0B2D80240B" modified="2016-09-07" version="1">MAGLVQDCFSIGSTVECTTCYDANVEGEVLAFDQQTKMLILKCPSASKSPKLNDVYIVNLAMCSDVQVKKEVCIVPEQPLSLNLERLSTRARNQVEQKRLQLSALSAGVSPEGQNLYMAIARTIKQVSWNGPNIVVCKDVTITPPYKVDNVNSSDQRQLSYVKKIVEKHENDQANINQSTSAADIAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEC2</accession>
    <name>A0A182PEC2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEC2"/>
    <dbReference type="STRING" id="199890.A0A182PEC2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005277-RA">
        <property type="protein sequence ID" value="AEPI005277-PA"/>
        <property type="gene ID" value="AEPI005277"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005277"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20958">
        <property type="entry name" value="IgI_5_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20959">
        <property type="entry name" value="IgI_6_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001035">
        <property type="entry name" value="Down syndrome cell adhesion molecule-like protein Dscam2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="52"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="143"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="239"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005277-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="345" mass="37416" checksum="D13E6CFD4F02F96F" modified="2016-09-07" version="1">MIGQYVTVHGDVISHVNISHVMVEDGGEYSCAAENRAGKTAHSARLNIYGLPYIRLIPKVTAVAGHTLYLKCPVAGYPIEEIHWERGGRELPEDMRQKVQSDGTLEIKEVQKSLDSGVYTCWARNKQGHSARRSGEVAVIVPPKLNPFHSSILSLNVGDRASITCSVIKGDIPLTITWRKDGRPIDPTQRMSVTQVDQYNSILLIENLSADHTGNYSCVVRNTAAETEGHQSLLVNVPPNIEPFSFQDGLAEGMRTRTVCGVSKGDPPLTLKWLKDGDPLLSTLLGANISTLDQYSSLLNIPSLSAAHSGDYTCVASNPAAEVKFTASLQVKVALARSGFAADQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEG3</accession>
    <name>A0A182PEG3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEG3"/>
    <dbReference type="STRING" id="199890.A0A182PEG3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005318-RA">
        <property type="protein sequence ID" value="AEPI005318-PA"/>
        <property type="gene ID" value="AEPI005318"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005318"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="11">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005318-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="89" mass="10095" checksum="30692CD61E3D52D8" modified="2016-09-07" version="1">MDVSLENLSSSQKDELMSTIKQKIAIANAQELVTKMTEKCFKKCVGKPGQDLDGSEQKCIAMCMDRFMDSWNVVSRALTQRLQQEQYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEI7</accession>
    <name>A0A182PEI7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEI7"/>
    <dbReference type="STRING" id="199890.A0A182PEI7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005342-RA">
        <property type="protein sequence ID" value="AEPI005342-PA"/>
        <property type="gene ID" value="AEPI005342"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005342"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005342-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="649" mass="66370" checksum="C98D7E1B1D08FD81" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEN1</accession>
    <name>A0A182PEN1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEN1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005386-RA">
        <property type="protein sequence ID" value="AEPI005386-PA"/>
        <property type="gene ID" value="AEPI005386"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005386"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="511"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="752"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="829"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005386-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="883" mass="101699" checksum="9DA18E38089C2E25" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEX3</accession>
    <name>A0A182PEX3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEX3"/>
    <dbReference type="STRING" id="199890.A0A182PEX3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005478-RA">
        <property type="protein sequence ID" value="AEPI005478-PA"/>
        <property type="gene ID" value="AEPI005478"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005478"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042327">
        <property type="term" value="P:positive regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18318">
        <property type="entry name" value="BTB_POZ_KCTD20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039886">
        <property type="entry name" value="BTBD10/KCTD20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039885">
        <property type="entry name" value="BTBD10/KCTD20_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637:SF0">
        <property type="entry name" value="AT10158P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16017">
        <property type="entry name" value="BTB_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="108"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005478-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="433" mass="48439" checksum="B1F3B5D94B89256F" modified="2016-09-07" version="1">MELQLHRKQGTAAAQQRDGATGTVGSGSGSSGASSSGGNGAISKNDSYDSSHSSSNTEDTTETDDRRRKMMKNRARNNRLMQQQQQQQQQNTTDSAKVAAGKKLAENERITLVVDNTTFSVNVSMLTAQPETMLGRMFSTGFEFTHPNERGEYEVAEGISRTVFRAILEYYLSGVVRCPPTVSVQELREACDYLLIPFNANTIRCQNLRGLLHELSNEGASIQFEAFLEQLILPLMVDAARQGHRECHIVVLSEDDIIDWDAEYPPQMGEEDCQTVANTAMYRFFKYIENRDVAKQVLKDRGLKKIRLGIEGYPTYKEKIKRRPSGRMEVIYNYLQRPFIHMSWEKEEAKSRHVDFQCVKSKSVTNLAEATADPALELDSAGNPLPQRHFEISHEPDAEPFMRPDALLDGDEGAIGGLPNGDEIGLLVPEEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEY1</accession>
    <name>A0A182PEY1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEY1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005486-RA">
        <property type="protein sequence ID" value="AEPI005486-PA"/>
        <property type="gene ID" value="AEPI005486"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005486"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131340" evidence="2">
        <location>
            <begin position="25"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005486-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="172" mass="19396" checksum="E0D5E3E714126F29" modified="2016-09-07" version="1">MITHWTLIVLVAVAITGPYTVALARPLEPDAPAEIYSELAEEFQRLHNQEIRFLQYLSVQAERQQREEAYLQAQREQQLALEARGAALLDDAGTLLDDIPQDFGRAEDGAANGSGRNLNGFGHETATQSEPVQKAIPHQKSKADKKNNHYMSLCHFKLCNMGRKRNQRFPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF91</accession>
    <name>A0A182PF91_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Armadillo repeat-containing domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PF91"/>
    <dbReference type="STRING" id="199890.A0A182PF91"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005597-RA">
        <property type="protein sequence ID" value="AEPI005597-PA"/>
        <property type="gene ID" value="AEPI005597"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005597"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46241">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 4 ARMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46241:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="143"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="184"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="410"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005597-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="76362" checksum="C195409663F6A631" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFR5</accession>
    <name>A0A182PFR5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Fructose-1,6-bisphosphatase isozyme 2</fullName>
            <ecNumber evidence="9">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">D-fructose-1,6-bisphosphate 1-phosphohydrolase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Muscle FBPase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="31">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Homotetramer. Interacts with ALDOA; the interaction blocks inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+). Interacts with alpha-actinin and F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Myofibril</location>
            <location evidence="4">Sarcomere</location>
            <location evidence="4">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 27">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A182PFR5"/>
    <dbReference type="STRING" id="199890.A0A182PFR5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005772-RA">
        <property type="protein sequence ID" value="AEPI005772-PA"/>
        <property type="gene ID" value="AEPI005772"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005772"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000005">
        <property type="entry name" value="Fructose-1,6-bisphosphatase isozyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001057">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001204">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="19 27" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="16" id="KW-0965">Cell junction</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 27" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="30">
        <location>
            <begin position="20"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="26">
        <location>
            <begin position="551"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="28">
        <location>
            <begin position="843"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="29">
        <location>
            <begin position="1036"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00037516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00038670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00040321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00042757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00043165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005772-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1166" mass="132237" checksum="60707EF136FF76C0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGI4</accession>
    <name>A0A182PGI4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGI4"/>
    <dbReference type="STRING" id="199890.A0A182PGI4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006043-RA">
        <property type="protein sequence ID" value="AEPI006043-PA"/>
        <property type="gene ID" value="AEPI006043"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006043"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131403" description="LRRCT domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006043-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60715" checksum="28D93D396B1B0867" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGR2</accession>
    <name>A0A182PGR2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182PGR2"/>
    <dbReference type="STRING" id="199890.A0A182PGR2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006121-RA">
        <property type="protein sequence ID" value="AEPI006121-PA"/>
        <property type="gene ID" value="AEPI006121"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006121"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000010">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006121-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="350" mass="37959" checksum="42289AD9E1A3E7B2" modified="2016-09-07" version="1">MTLEAIKYKSGQLQILDQLLLPAESKYIPIDGVKDGWNAIHKMQVRGAPAIAIVGCLSLVVEIYDKQYDTKAALAAEIGEQLEYLVTSRPTAVNLKLAADEMKALSESILSKDDIDVDEMRRSIIKEIECLLEKDISDNRAIGEHGANVLLKGVDRPLQLLTHCNTGSLATAGYGTALGVIRSVNERNLLEHVYCTETRPYNQGARLTAYELVHDKLPATLVTDSMVAALLNSRKIDAIIVGADRVAANGDTANKIGTYQMAVVAKHHGVPFYVAAPFTSIDVAISDGTCIKIEERPDHELTHIGGQRIAAPGIGCWNPAFDVTPAELITGIITERGVLKPSEVATKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHA1</accession>
    <name>A0A182PHA1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Gujja S."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Larimer J."/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070920">
        <property type="term" value="P:regulation of regulatory ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051247">
        <property type="entry name" value="RLC_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205:SF5">
        <property type="entry name" value="BLANKS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="270"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006586-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="330" mass="35874" checksum="BA83590709D0317A" modified="2016-09-07" version="1">MNEDAPLPEPFTDTVKAQESGNGKVREIRHIVKKSLNALERKKSEKERKARQLRRLRKWLMPKNAIVALHELQGPGMAEFIVNTNGQETKAEIVINNIRYEATAPSKNLAKAKASEKALRDLIFSQMTRLKQQRSSGVAATATTSATGDKVDGANGGAGSSSNNTAPEPEPMDCIETEDLPMEHLAAFALHKLFTQWEAEGFEVPFIKPSRSKAAAVAAATTTTTNTQGENGGTNVSIMPKVTKTVADLPPNASSRHPTALFAYMRPQISYEDLGSNNNQSNNEFTAGLRSDGQYFIGKGRSKKLARKAAAIEACKILFGVEFDESVLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIA3</accession>
    <name>A0A182PIA3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIA3"/>
    <dbReference type="STRING" id="199890.A0A182PIA3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006665-RA">
        <property type="protein sequence ID" value="AEPI006665-PA"/>
        <property type="gene ID" value="AEPI006665"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006665"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15393">
        <property type="entry name" value="7tmA_leucokinin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000265">
        <property type="entry name" value="Blast:Neuropeptide Y receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="56"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006665-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="565" mass="63703" checksum="018D43F38B52CD02" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIC9</accession>
    <name>A0A182PIC9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCM family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIC9"/>
    <dbReference type="STRING" id="199890.A0A182PIC9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006691-RA">
        <property type="protein sequence ID" value="AEPI006691-PA"/>
        <property type="gene ID" value="AEPI006691"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006691"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20092">
        <property type="entry name" value="MBT_dScm-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09578">
        <property type="entry name" value="SAM_Scm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000016">
        <property type="entry name" value="polycomb protein SCMH1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.190">
        <property type="entry name" value="SLED domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047531">
        <property type="entry name" value="SAM_Scm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021987">
        <property type="entry name" value="SLED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038348">
        <property type="entry name" value="SLED_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF132">
        <property type="entry name" value="POLYCOMB PROTEIN SCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12140">
        <property type="entry name" value="SLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="MBT" evidence="8">
        <location>
            <begin position="311"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="8">
        <location>
            <begin position="417"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="1017"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="685"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="779"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="824"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006691-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1090" mass="114439" checksum="2F6DC663EC870D40" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIL9</accession>
    <name>A0A182PIL9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIL9"/>
    <dbReference type="STRING" id="199890.A0A182PIL9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006781-RA">
        <property type="protein sequence ID" value="AEPI006781-PA"/>
        <property type="gene ID" value="AEPI006781"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006781"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000022">
        <property type="entry name" value="Matrix metalloproteinase 1, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000007">
        <property type="entry name" value="stromelysin-3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="19">
        <location>
            <begin position="106"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="17">
        <location>
            <begin position="296"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="17">
        <location>
            <begin position="342"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="17">
        <location>
            <begin position="388"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="17">
        <location>
            <begin position="438"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="16">
        <location>
            <begin position="84"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="14">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="15">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006781-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="564" mass="63132" checksum="2E843B5C5B9B45B5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIT7</accession>
    <name>A0A182PIT7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblMetazoa" id="AEPI006850-RA">
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        <property type="gene ID" value="AEPI006850"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006850"/>
    <dbReference type="Proteomes" id="UP000075885">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006850-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="183" mass="19506" checksum="D12EB322C8214B19" modified="2016-09-07" version="1">MPSMSSTWIDERPGDHGNGSPVARRPHRETSEPSEVFSNISNQSSNGSGRSGVRRFGDIFRNRLKLAGAAAMRTFNESFPQECKIHTDEENGVQTPSPKVATKTRVGRMGSFDSLDAVLVNERAIGRRDRTFTERSNTLAGSGTATGEGGAGAGGGSAGAGGLRSRRSSTMFRQRTVQRTSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIX6</accession>
    <name>A0A182PIX6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIX6"/>
    <dbReference type="STRING" id="199890.A0A182PIX6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006889-RA">
        <property type="protein sequence ID" value="AEPI006889-PA"/>
        <property type="gene ID" value="AEPI006889"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006889"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131454" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006889-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7609" checksum="7BE51B6FE4C54EA8" modified="2016-09-07" version="1">MLAAFVSLQLTSMSTVTVEAVLGRTATLPCDIEPEELNDRVYMVLWFRESAGKPLYRGKQYRQLGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJH9</accession>
    <name>A0A182PJH9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJH9"/>
    <dbReference type="STRING" id="199890.A0A182PJH9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007093-RA">
        <property type="protein sequence ID" value="AEPI007093-PA"/>
        <property type="gene ID" value="AEPI007093"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007093"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF230">
        <property type="entry name" value="CUTICULAR PROTEIN 47EE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUTICLE"/>
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        <property type="entry name" value="CHIT_BIND_RR_2"/>
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    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131396" evidence="3">
        <location>
            <begin position="23"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
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            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007093-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="257" mass="28776" checksum="D71A4066044DBA86" modified="2016-09-07" version="1">MDLIENNQFALVLVIVACGAVAKPQNQYGHSSYTKNTGVRNTSVGHRLTNQHQQYQQQQHQQHQHQQHQQQQQHQSQNHFAHQRQPQALRAPLLPPHNPNQFSQRLQQPFPNAIRPFVPITSYSNDVSYDGSYSYAYTTGDGQQQQAQGYLKNAGRKDLEAQSVQGSYSYTSPEGQLITVTYIADENGTALRNTSFRAEGAHLPTPPPIPEAIQKSLALIAQTQPVSAQFNAAYNQPRFHQAGHIPSASGHNYNRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJP1</accession>
    <name>A0A182PJP1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SBF2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJP1"/>
    <dbReference type="STRING" id="199890.A0A182PJP1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007155-RA">
        <property type="protein sequence ID" value="AEPI007155-PA"/>
        <property type="gene ID" value="AEPI007155"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007155"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039872">
        <property type="entry name" value="KIAA0513"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022096">
        <property type="entry name" value="SBF1/SBF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13663">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 6430548M08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13663:SF2">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 6430548M08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12335">
        <property type="entry name" value="SBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBF1/SBF2" evidence="2">
        <location>
            <begin position="361"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007155-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="609" mass="67767" checksum="0F7655A111AFA4FE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK12</accession>
    <name>A0A182PK12_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PK12"/>
    <dbReference type="STRING" id="199890.A0A182PK12"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007278-RA">
        <property type="protein sequence ID" value="AEPI007278-PA"/>
        <property type="gene ID" value="AEPI007278"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007278"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000025">
        <property type="entry name" value="Neuronal PAS domain protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000007">
        <property type="entry name" value="single-minded homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000054">
        <property type="entry name" value="Trachealess, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
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        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF26">
        <property type="entry name" value="PROTEIN TRACHEALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="72"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="162"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="470"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007278-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="618" mass="67621" checksum="28E39E59643B8FAA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKR0</accession>
    <name>A0A182PKR0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKR0"/>
    <dbReference type="STRING" id="199890.A0A182PKR0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007527-RA">
        <property type="protein sequence ID" value="AEPI007527-PA"/>
        <property type="gene ID" value="AEPI007527"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007527"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000019">
        <property type="entry name" value="Ligand-dependent corepressor isoform 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF102">
        <property type="entry name" value="PIPSQUEAK, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="475"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="529"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="584"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="689"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="711"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
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        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="768"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="853"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007527-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1006" mass="107649" checksum="A29B23F86CD2CE8D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLV5</accession>
    <name>A0A182PLV5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hexamerin A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLV5"/>
    <dbReference type="STRING" id="199890.A0A182PLV5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007927-RA">
        <property type="protein sequence ID" value="AEPI007927-PA"/>
        <property type="gene ID" value="AEPI007927"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007927"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAEMOCYANIN"/>
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    </dbReference>
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        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="HEMOCYANIN_2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131586" description="Hexamerin A" evidence="2">
        <location>
            <begin position="19"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin N-terminal" evidence="4">
        <location>
            <begin position="36"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin middle" evidence="3">
        <location>
            <begin position="150"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin C-terminal" evidence="5">
        <location>
            <begin position="430"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007927-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="81020" checksum="3AD495A75BDAF839" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLY6</accession>
    <name>A0A182PLY6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLY6"/>
    <dbReference type="STRING" id="199890.A0A182PLY6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007958-RA">
        <property type="protein sequence ID" value="AEPI007958-PA"/>
        <property type="gene ID" value="AEPI007958"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007958"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00916">
        <property type="entry name" value="Npc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033916">
        <property type="entry name" value="ML_Npc2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF36">
        <property type="entry name" value="NIEMANN-PICK TYPE C-2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="6">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007958-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="136" mass="14801" checksum="BC01213EBD46E208" modified="2016-09-07" version="1">MAITKTKIVTYANETAIGKYTQVEVSNCADSDASCVLKRNSNATISITFTSGEDLSELKAVVHGIILGMEVPFKLPNDNGCKDSGLECPLAKDTSYRYSTTLPVLKQYPKVSVEVKWELKAGEKDVLCVLIPAKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLZ6</accession>
    <name>A0A182PLZ6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLZ6"/>
    <dbReference type="STRING" id="199890.A0A182PLZ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007968-RA">
        <property type="protein sequence ID" value="AEPI007968-PA"/>
        <property type="gene ID" value="AEPI007968"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007968"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050930">
        <property type="term" value="P:induction of positive chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06759">
        <property type="entry name" value="PDZ3_PDZD2-PDZ1_hPro-IL-16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055287">
        <property type="entry name" value="IL-16-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48484">
        <property type="entry name" value="PRO-INTERLEUKIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48484:SF2">
        <property type="entry name" value="PRO-INTERLEUKIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007968-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="232" mass="25041" checksum="44DC1C00E0E8FBC4" modified="2016-09-07" version="1">MGPFGTPFEIKLQQPPIEKQWGKPFPFPVGHCDRISESKLGHGHTKSNGGITFADSSKLGSDQLRHLNHRTAEDHRNDDVDDEDDRDSIEESKFCTLPRHGPNAFTIRQARFSKGNGSKALGFSIVGGKDSPKGSMGIYVKTIYPNGQAAEKGTLQAGDEILSVNGKAFQGLSHQEAINVFKAIKTGEVTILIGRRNNRRKLETPSPTDSGTGTAPPSTTGSPTNAVTCNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PML5</accession>
    <name>A0A182PML5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF243 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PML5"/>
    <dbReference type="STRING" id="199890.A0A182PML5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008189-RA">
        <property type="protein sequence ID" value="AEPI008189-PA"/>
        <property type="gene ID" value="AEPI008189"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008189"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040003">
        <property type="term" value="P:chitin-based cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004145">
        <property type="entry name" value="DUF243"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927">
        <property type="entry name" value="FI07246P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927:SF13">
        <property type="entry name" value="TWEEDLEBETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03103">
        <property type="entry name" value="DUF243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00690">
        <property type="entry name" value="DM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131546" description="DUF243 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="DUF243" evidence="3">
        <location>
            <begin position="78"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008189-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="204" mass="22900" checksum="92A266D737867581" modified="2016-09-07" version="1">MKIYVIFQIFLTCIVCALARPEPEPPRARIVVPAKQQQLPQYEYGAPKPEYGPPAEEYGPPPPTVYGPPAREYGPPPKLITKNVYVHVPPEEPTEIIKSPVLEAPIPKKHYKIIFIKAPAPPAPIKQVIPPQPQDEHKTLVYVLVKKPEEPAPLEIPVPETTEPNKPEVYFIKYKEGEKEPHKQYGPPAPAYGPPSGPARYQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMY8</accession>
    <name>A0A182PMY8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PMY8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008312-RA">
        <property type="protein sequence ID" value="AEPI008312-PA"/>
        <property type="gene ID" value="AEPI008312"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008312"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008312-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="110" mass="13070" checksum="6B8730E197299ADC" modified="2016-09-07" version="1">MYEDNPDTTVRFRTSQKGKLQLSYGGFYYCMEKKIHHKEYWRCIYYTTKIKCHGRLHRYDNIVHHMGAHNHAPQLFKRADYKRLSEIVMPDKMLSGEKNPTKNKSSSASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN01</accession>
    <name>A0A182PN01_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PN01"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008325-RA">
        <property type="protein sequence ID" value="AEPI008325-PA"/>
        <property type="gene ID" value="AEPI008325"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008325"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008325-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="600" mass="67224" checksum="ED8A3F71296BCBDB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN72</accession>
    <name>A0A182PN72_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN72"/>
    <dbReference type="STRING" id="199890.A0A182PN72"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008396-RA">
        <property type="protein sequence ID" value="AEPI008396-PA"/>
        <property type="gene ID" value="AEPI008396"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008396"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008396-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="428" mass="48457" checksum="2E8682D22F4CF91C" modified="2016-09-07" version="1">MASTPEKVPLEQEKQQPSTNPLYPTIGQDAANPLLPPQVPQGYAVAPMAAGPPAPPGYMPVPQMAGMPIMTQPGAIPMQPVLGQQQVSKMTPKKRAQEYFTSCVSVDRLCVSDESSSPVDREPRDESKRKQYQTRRLVIVVWHVLEKKLAKCGRMMRSVRLGKRSEKTKAKEVCANDRFDQQFERLITEEERRWLGERGWMPIPQGIPNCPPGLEYLTAVDQLLVHQKVELLEAFTGFETANKYTVKNTLGQNVYWAVEDTSFCNRMCCGPDRPFEMKIMDNFQNEVLHLHRDLRCKSCCFPCCLQKLEVSAPPGNVIGTVVQKWSLCRPVFDIRDRNNETVLTIRGPVCQCPCSDIKFAVFTKDGTEVGKVTKQWAGIVQEHFTDADNFGITFPMDLDVRVKATMLGALFLIDYMYFESSDNKKIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNH7</accession>
    <name>A0A182PNH7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNH7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008504-RA">
        <property type="protein sequence ID" value="AEPI008504-PA"/>
        <property type="gene ID" value="AEPI008504"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008504"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39942">
        <property type="entry name" value="BCDNA.LD26519-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39942:SF1">
        <property type="entry name" value="BCDNA.LD26519-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="3">
        <location>
            <begin position="148"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008504-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="551" mass="62632" checksum="E583CA5DD30DD9AA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPZ0</accession>
    <name>A0A182PPZ0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PNO1 second type I KH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPZ0"/>
    <dbReference type="STRING" id="199890.A0A182PPZ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009020-RA">
        <property type="protein sequence ID" value="AEPI009020-PA"/>
        <property type="gene ID" value="AEPI009020"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009020"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000142">
        <property type="entry name" value="AGAP004145-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PNO1 second type I KH" evidence="2">
        <location>
            <begin position="57"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009020-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="148" mass="16511" checksum="0D8004979729B089" modified="2016-09-07" version="1">MIRYNVKQSQVEIKTTAETPDPTYLQKAADFVRAFALGFEVEDALALIRLDDLFIESFDVTDVKALKGDHLSRAIGRLAGKGGRTKFTVENTTKTRIVLQDSKIHIMGSYKYIQHAKRALSHLILGSPASKVYGNLRTVAANQNSQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQF8</accession>
    <name>A0A182PQF8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FK506-binding protein</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PQF8"/>
    <dbReference type="STRING" id="199890.A0A182PQF8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009189-RA">
        <property type="protein sequence ID" value="AEPI009189-PA"/>
        <property type="gene ID" value="AEPI009189"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009189"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="278"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009189-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="366" mass="40025" checksum="6014EBA95C7EEBD5" modified="2016-09-07" version="1">MFWGLILKPGKKYSKVVEQDFHLTHAALDLSESNGDVQVMLTSENITYLLCTLNKSIPQVVLDQEFATGDEISFATKGQGVVHLTGNVLPDGMEDMGDEEEDDEEMEEDEEDVPAENGAGKARTAKQAAKLKVAKKIAAGEVSDDEDEDDATFTESMLDESVLNGAEDDDDSEDDDEDGDEDDDEDDDEDGEDDEDDDDDEEEDDDDDDDDEEEEEDQQPKAKQAKLSNGNAKGSKDAAPKKQEQQQQDQKKGGVRTLQDGLMVEDLKVGNGPEAKPGKKIAVYYEGRLKSNNKVFDSTNKGPGLKFALGRGEVIKGWDLGVAGMKVGGKRRLVIPHKLAYGTKGSPPVIPPCSTLVFEVELKKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQJ1</accession>
    <name>A0A182PQJ1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 SUMO-protein ligase NSE2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E3 SUMO-protein transferase NSE2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Non-structural maintenance of chromosomes element 2 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQJ1"/>
    <dbReference type="STRING" id="199890.A0A182PQJ1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009222-RA">
        <property type="protein sequence ID" value="AEPI009222-PA"/>
        <property type="gene ID" value="AEPI009222"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009222"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="14">
        <location>
            <begin position="116"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009222-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="203" mass="23491" checksum="5D41464A805439A3" modified="2016-09-07" version="1">MNMLEANMRKVSDSISNTVRLAAEFGDESLKDLKLYSSLVEKLCEIDSKMTSHRKAIAESYSEQTAESFNHCYESNLDRNKPDVRRHKRYKDFVQYAKPLLEPSLQGQSTQEQSNEDNDLVIEGNVGDMIDPILKRPLEVPVRNKQCNHIYEKHAIEELLRQNPRTRCPVMGCAAQGYIRKEMLEIDVRLQQQLLQSRSVFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQV8</accession>
    <name>A0A182PQV8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">oxaloacetate tautomerase</fullName>
            <ecNumber evidence="5">5.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Fumarylacetoacetate hydrolase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>oxaloacetate = enol-oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:16021"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17479"/>
            <dbReference type="EC" id="5.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="4">
            <dbReference type="Rhea" id="RHEA:16023"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PQV8"/>
    <dbReference type="STRING" id="199890.A0A182PQV8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009339-RA">
        <property type="protein sequence ID" value="AEPI009339-PA"/>
        <property type="gene ID" value="AEPI009339"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009339"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000017">
        <property type="entry name" value="Acylpyruvase FAHD1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00042340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009339-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="226" mass="24480" checksum="9588DD4BF293229B" modified="2016-09-07" version="1">MPTTQFFQSTRKIIGAGVNYKEILRLTNAPKPDAPVIFFKPISSLLEAGNGAATNSTTPTIRIPRVFGGVINFEAELGVIIGRRCANVPTDQAMSYVCGYCLALDMTGMDFILDARPKGLPWCLGKGFDTSTPVSGLVTRAELPNPDDVRVWCDVNGVRKQDDSTRNLIFPIAELIAYVSRFMTLEENDLLLTGTPAGAGPVRHGDVIVCGLGENLVTMRCEVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR96</accession>
    <name>A0A182PR96_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Membrane</location>
            <topology evidence="2 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PR96"/>
    <dbReference type="STRING" id="199890.A0A182PR96"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009478-RA">
        <property type="protein sequence ID" value="AEPI009478-PA"/>
        <property type="gene ID" value="AEPI009478"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009478"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008020">
        <property type="term" value="F:G protein-coupled photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001391">
        <property type="entry name" value="Opsin_lateye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00578">
        <property type="entry name" value="OPSINLTRLEYE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 16" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4 16" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="14 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="65"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009478-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="370" mass="41543" checksum="1096EC20F896A22F" modified="2016-09-07" version="1">MAAFVEPHFDAWSQGSGNMTVVDKVPPEMLHMVHPHWNQFPPMNPLWHSILGFAIFMLGMISMTGNGCVMYIFTNTKSLRTPSNLLVVNLAFSDFFMMFTMGPPMVINCWHETWTFGPFACELYAMLGSLFGCASIWTMTMIAFDRYNVIVKGLSAKPMTNNGALLRILGVWAFALFWTLAPLFGWNRYVPEGNMTACGTDYLTQTWLSRSYIIIYAIFVYWLPLLTIIYSYTFILKAVSAHEKNMREQAKKMNVASLRSQEAQNTSTEMKLAKVALVTISLWFMAWTPYLVINFTGIFKAAPISPLATIWGSLFAKANAVYNPIVYGISHPKYRAALYQKFPSLSCQDAPVDDGQSVASGATQASEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRL7</accession>
    <name>A0A182PRL7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FRA10AC1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRL7"/>
    <dbReference type="STRING" id="199890.A0A182PRL7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009601-RA">
        <property type="protein sequence ID" value="AEPI009601-PA"/>
        <property type="gene ID" value="AEPI009601"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009601"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019129">
        <property type="entry name" value="Folate-sensitive_fs_Fra10Ac1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF25">
        <property type="entry name" value="PROTEIN FRA10AC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09725">
        <property type="entry name" value="Fra10Ac1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009601-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="30346" checksum="0B4C5521141A59BB" modified="2016-09-07" version="1">MYHRNLAHLNPYELHKHLINEYMLTKPGATKLLQRDTSRDKTDHDVVRENHRFLWDGETVDSWEKQLAKKYYDKLFREYCISDLSRYKENKVAMRWRIEKEVVVGKGQFVCGDRHCEERNELRSWEVNFSYQEHGQKKNALVKLRLCPKCSDKLNYHSKKREIKRLKKRDRKTKASSGNKKVPDEVSPSAVVTSNPEDIPRETSAQESVEAEELTETLGEKDGSSVPEDAEGSWTKGPEVEEKTREEEFDEFLEDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRR5</accession>
    <name>A0A182PRR5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRR5"/>
    <dbReference type="STRING" id="199890.A0A182PRR5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009650-RA">
        <property type="protein sequence ID" value="AEPI009650-PA"/>
        <property type="gene ID" value="AEPI009650"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009650"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009650-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="210" mass="23750" checksum="E163353914C7A678" modified="2016-09-07" version="1">MESTSCSKTQAKYNCPRCNILYCSVQCYRSQQHLECSEGFYRENVVEELALQKAEADASKSTKSMLEILQRIEQTDALRDEESSRGAASDPEYVNGELDSDDEALEDELASRLDGIDLDNAAAVWDRLTTTEKEEFQRFVENGDIVKMLPEPNTWWAHDYKVSLVQPAKKQSEQETKMLEACPKLVKNIPKLSDILPNVPSPAGMYTKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS00</accession>
    <name>A0A182PS00_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanine nucleotide-binding protein G(F) subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PS00"/>
    <dbReference type="STRING" id="199890.A0A182PS00"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009735-RA">
        <property type="protein sequence ID" value="AEPI009735-PA"/>
        <property type="gene ID" value="AEPI009735"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009735"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000010">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha-13 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001723">
        <property type="entry name" value="Guanine nucleotide-binding protein G(f) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF367">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN G(F) SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="177"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="279"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009735-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="44795" checksum="DBB6FE77A8B4EEC0" modified="2016-09-07" version="1">MLLIDCFRRPSHELQARKKQSSKELVQMRKLYRDPVKVLLLGAGESGKTTIIKQMRILHVQNSYSFDERLEKLSDIYENIHESIYELVRQVILLELDFDSVTNQRCAEYILRIGATAPWNLSTEYVQCVRRLWSDSGVKRCYKRSNEFQLIDSAKYFLDRVEKISMPGYIPSNSDILNCRKTTTGIQEIRFNVPMPSSLGGGVQEFRMFDVGGQRHHRSKWMQAFEGVQAVLFLISCGGFDQTLREDPKQNRLAEGFELFRGVWHNRFLAETGVIVFMNKQDVLEQKLLAGQSIRTYFPDYDDYVAFADKDQLYDELTRTRSFIRSKLVDITNEPPRRTSHLVGRKRTCYFHFTIATDTQNVRTVFNDVHNIILTKNLSKMDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS51</accession>
    <name>A0A182PS51_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">3-hydroxyacyl-CoA dehydrogenase type-2</fullName>
            <ecNumber evidence="3">1.1.1.53</ecNumber>
            <ecNumber evidence="4">1.1.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">3-hydroxyacyl-CoA dehydrogenase type II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial ribonuclease P protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Type II HADH</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:30800"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:30801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>11-dehydrocorticosterone + NAD(+) = pregn-4-ene-3,11,20,21-tetraone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42020"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78600"/>
            <dbReference type="ChEBI" id="CHEBI:78601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:24613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42024"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78602"/>
            <dbReference type="ChEBI" id="CHEBI:78603"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:42025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42004"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:36713"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.53"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:42006"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42008"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28952"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78594"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42009"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22433"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:22434"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42012"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17650"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:42013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42016"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16962"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78596"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ursodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42028"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78604"/>
            <dbReference type="ChEBI" id="CHEBI:78605"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:42029"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 20">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="3"/>
    <dbReference type="EC" id="1.1.1.62" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PS51"/>
    <dbReference type="STRING" id="199890.A0A182PS51"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009786-RA">
        <property type="protein sequence ID" value="AEPI009786-PA"/>
        <property type="gene ID" value="AEPI009786"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009786"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008209">
        <property type="term" value="P:androgen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05371">
        <property type="entry name" value="HSD10-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000215">
        <property type="entry name" value="3-hydroxyacyl-CoA dehydrogenase type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009786-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="255" mass="26968" checksum="005D0F5C7852A826" modified="2016-09-07" version="1">MLKNAVALVTGGASGLGRATVERFARAGYNVLLCDLPTSKGNDVAKELGEKVVYVPVDVLSEKDVSGALELAKSKFGRLDVSVNCAGIAVAVKTYNFNKKVAHKLEDFQRVLLVNTAGTFNVIRLSAGLMGENEPNADGQRGVIVNTASVAAYDGQIGQAAYAASKAAVVGMTLPIARDLSTQGIRIVTVAPGLFNTPMLQALPEKVRAFLAKTVPFPQRLGEPAEYAQLVQSIVDNPMLNGEVIRLDGALRMMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS90</accession>
    <name>A0A182PS90_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PS90"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009825-RA">
        <property type="protein sequence ID" value="AEPI009825-PA"/>
        <property type="gene ID" value="AEPI009825"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009825"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009825-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="422" mass="46880" checksum="EFC7FB82A8E47E01" modified="2016-09-07" version="1">MPAYAGFDSFASSRRTAESIYYTAKEYDSAEESDYVRRAIFEEGPNTIFNRRYVDPWDMENYVYIRKQVMDPTSESEVPPSPAGEPIQSKFYYVPGELNGSELVECRDCSSAELIDPEFDSDMHGDDPERQSVILRPEQDGLDGEPHPLGEERPSEIEDELQVEDDEDEDGFYTERYDTVMDEDSIGGDEHVYSSYTDLETSSTEQPSSCDSSMSALRLHTPGFGKSASSRRPIVLPKPLPQLEFPGPPSYEYYEPSCCYMPLPPPPPPPPPPAHFHHAHHHHHHHGHAALPLGPPPSVTGTILSDNHNYYTLNDCLECARQEAEHVPLYATTSSGGGGVGLAGSTVGSPTRRRSRSVSVVSQSMSIARRPSQMLDPATAIAIAATNANVCYTPQHFSLSKKGLLQIDYSCNWNNLDRYIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSD4</accession>
    <name>A0A182PSD4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSD4"/>
    <dbReference type="STRING" id="199890.A0A182PSD4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009869-RA">
        <property type="protein sequence ID" value="AEPI009869-PA"/>
        <property type="gene ID" value="AEPI009869"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009869"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF14">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009869-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="236" mass="26952" checksum="496FA905B99D37A2" modified="2016-09-07" version="1">MEPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKNGDQSKSNTSTATGQPGGAGNQKKSRKNNVSALNTKSKQQQQTIQNECLRTDSLESMADVHATITSSNSTTSQYMSSSDGNGIIPLANGTNGTNGSGSSLRNDHLSQHQQHQHHPQIQHQQHQSQLNHQSSNNNNNNSNDTGNMNSVQQHSMNIKNDYDLTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSG1</accession>
    <name>A0A182PSG1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSG1"/>
    <dbReference type="STRING" id="199890.A0A182PSG1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009896-RA">
        <property type="protein sequence ID" value="AEPI009896-PA"/>
        <property type="gene ID" value="AEPI009896"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009896"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF11">
        <property type="entry name" value="UNC93-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="726"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009896-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="782" mass="85752" checksum="FC7CC1BEA1BAAA3F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PT89</accession>
    <name>A0A182PT89_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PT89"/>
    <dbReference type="STRING" id="199890.A0A182PT89"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010175-RA">
        <property type="protein sequence ID" value="AEPI010175-PA"/>
        <property type="gene ID" value="AEPI010175"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010175"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF3">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010175-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="143" mass="15995" checksum="FB3A7B9EFD8E3DA2" modified="2016-09-07" version="1">MGAIVPQLELNQVETCVDGFPYLNRCPSGLYFDDIQKYCTFKAEAKCGPLASTPTATTESPIDLAKKCNPAECELPYCYCNKDGTLIPKGLNPDETPQIILLTFDGAVNLNNYEHYRKVFNGKRKNPNGCDIKGTFFISHEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTF7</accession>
    <name>A0A182PTF7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTF7"/>
    <dbReference type="STRING" id="199890.A0A182PTF7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010243-RA">
        <property type="protein sequence ID" value="AEPI010243-PA"/>
        <property type="gene ID" value="AEPI010243"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010243"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056198">
        <property type="entry name" value="LBD_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24061">
        <property type="entry name" value="LBD_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="13">
        <location>
            <begin position="229"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010243-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="638" mass="72498" checksum="B78707E652243D65" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU25</accession>
    <name>A0A182PU25_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PU25"/>
    <dbReference type="STRING" id="199890.A0A182PU25"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010461-RA">
        <property type="protein sequence ID" value="AEPI010461-PA"/>
        <property type="gene ID" value="AEPI010461"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010461"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071546">
        <property type="term" value="C:pi-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157:SF3">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010461-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="459" mass="52909" checksum="9D96814A7A6C66D0" modified="2016-09-07" version="1">MYRPAGYDDSDEDEFDELGYFHYSFPKQKQNISFTKDAPPPPEDYDDLLYNAILDGNLEETKCILQKDEYLRKGGTLRQGWPAMFYACFESKLPIVEYLLQEETIDVNRQYNLQTALMIACSSSKPSERVYQVVRLLLDYGAIIGVLDQYGCSPLMFACREGHLNVVKEIVGESSLLSTDNEGNTALFYAVNNNHLEVVKTLLRAGAQTHTVNRQGFNPRQCAVNRNYLDIAELFPPEETPYQMPTKYLCYSDYRNFLHGDQAQDPPGYFPDLGTMLLGMNSEAKLRLFSEANMNLVEFLTLSDERLKELGMKYPIERKRILLGLYDFHLHKWSRNSLWTMERQRVLDFYDILEALANVLKHVTVMQATLLYTKKLTEIHESDKFGCDKQCYSLKQHLVNLRATVEDFKAHMKDIHKLSAPNPVLHIMPSCNDRSSSDKMLKICCLAIGGLLLYLKLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU33</accession>
    <name>A0A182PU33_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PU33"/>
    <dbReference type="STRING" id="199890.A0A182PU33"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010469-RA">
        <property type="protein sequence ID" value="AEPI010469-PA"/>
        <property type="gene ID" value="AEPI010469"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010469"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010469-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="544" mass="62031" checksum="CA01015A8032E63A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUM0</accession>
    <name>A0A182PUM0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUM0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010657-RA">
        <property type="protein sequence ID" value="AEPI010657-PA"/>
        <property type="gene ID" value="AEPI010657"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010657"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032134">
        <property type="entry name" value="DUF4816"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16086">
        <property type="entry name" value="DUF4816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010657-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="123" mass="14679" checksum="E2A2D45D53B3AA54" modified="2016-09-07" version="1">MYFAAEALAHQHQHEDLVHHHPEALLHGLTEADHSLLHHDLHHDLHHDLHHHDVHHVHHDHVVVTAPQPTGFWKKKFIWKPRWVKSWQEKKVYVGVWKRVWGPVQVSEWVPIPKPPPGWTKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW22</accession>
    <name>A0A182PW22_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PW22"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011159-RA">
        <property type="protein sequence ID" value="AEPI011159-PA"/>
        <property type="gene ID" value="AEPI011159"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011159"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011159-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59690" checksum="E752BD0D2EE0B683" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX73</accession>
    <name>A0A182PX73_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX73"/>
    <dbReference type="STRING" id="199890.A0A182PX73"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011560-RA">
        <property type="protein sequence ID" value="AEPI011560-PA"/>
        <property type="gene ID" value="AEPI011560"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011560"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011560-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="357" mass="40614" checksum="6738736FD15CD127" modified="2016-09-07" version="1">MATTRLHALERKLERDPVLKEIVHGQVRMYLERGYAHKATEKELASADPKRTWYLPLNIVGHPRKPDKKRLVWDAAAKVKGVSLNTQLLKGPDLLVALPGVLSFNMRNWLSNEDTVLESLAEETGEKQRVIDFGQEEKQPRVLGLIWDPATDTFRFSINWHDELKPFINGEKRPSKRIVLRVIMSLFDPLGLLAPVLILGRIIMQDLWRSGTECDAEVGDREFVKWQQWISLLPGIHALSIPRWYMGGAGDVQCETTQLHVFTDASEQAYGCAAYFRFHTKGGIHCSLVMARSKVAPLKHQSIPRLELEAALLGARLARTVCENHDIAIKDKFIHTDSEVVLSWIRSPTRDFKQFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ84</accession>
    <name>A0A182PZ84_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZ84"/>
    <dbReference type="STRING" id="199890.A0A182PZ84"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015149-RA">
        <property type="protein sequence ID" value="AEPI015149-PA"/>
        <property type="gene ID" value="AEPI015149"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015149"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF187">
        <property type="entry name" value="CYTOCHROME P450 4AE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008132024" evidence="14">
        <location>
            <begin position="18"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015149-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="509" mass="59208" checksum="92FAB78DBECB7C56" modified="2016-09-07" version="1">MSVVLFLLVMLIVYGLAQVYRKRRQLHAIAAHFDGAKPHWLLGNVMEYPANDIPGIFETMVVLHKRYGKDLFNWGLLNDHMITVSSAANVEKVVMAKRNEKSSVYEFIELWLGQGLLISKGEKWFHRRKIITPTFHFKILESFVTVFNQEAEILIEKLGQYAGTGREFDIYEPISLYALDSICTTSMGVEINAQRHPENQYVCDVKRMSELILLRIFHVLSSFPRTYWYTMPHAWEQRKLIRRLHAFTDTVIQARRQQLLEKGKDDAIKDSQVEPEDEYTKRRDTFLDLLLNVRVDGNSLSNLDIREEVDTFMFEGHDTTTSGIAFTFYQLAKHPQIQEKLYQEIQDVLGTDFRHVPLTYNTLQNFPYLDMVVKESLRLLPPVSFIGRRLADDIEMNGVIIPAGTDFTIPIYVIHRNPAVFPDPERFDPERFSDENTLRRGPYDYIPFSIGSRNCIGQRYALLEMKVAIVRMVSFYRILPGDTMHEIRLKTDLVLRPDKTIPIKLVARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PK97</accession>
    <name>A0A240PK97_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrator complex subunit 14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Integrator subunit 14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PK97"/>
    <dbReference type="STRING" id="199890.A0A240PK97"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015332-RA">
        <property type="protein sequence ID" value="AEPI015332-PA"/>
        <property type="gene ID" value="AEPI015332"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015332"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000140">
        <property type="entry name" value="Uncharacterized protein (Fragment)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039841">
        <property type="entry name" value="INTS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045814">
        <property type="entry name" value="IntS14_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046471">
        <property type="entry name" value="IntS14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532:SF3">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19435">
        <property type="entry name" value="IntS14_b-barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20504">
        <property type="entry name" value="IntS14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="6">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 14 beta-barrel" evidence="7">
        <location>
            <begin position="283"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 14 beta-barrel" evidence="7">
        <location>
            <begin position="403"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 14 C-terminal" evidence="8">
        <location>
            <begin position="513"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015332-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="618" mass="68096" checksum="BB31C2B20E2DBDF7" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWJ0</accession>
    <name>A0A3F2YWJ0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWJ0"/>
    <dbReference type="STRING" id="199890.A0A3F2YWJ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015427-RA">
        <property type="protein sequence ID" value="AEPI015427-PA"/>
        <property type="gene ID" value="AEPI015427"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015427"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF270">
        <property type="entry name" value="ENTOMOGLYCEROPORIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015427-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="242" mass="26237" checksum="1D8536CC38A4C46A" modified="2019-01-16" version="1">MFLGCMGCLDGFDNTTTNFSRGIIFGFTVMVVIITFGVVSGAHINPVVSMASYIYGDLSFMMLMIYFVAQFTGALCGYGLLMGVAPQDYFNQALTNGHGSCVTAPHASLSSAEALAIEFIVTGILIWACCGVWDPRNAQHQDSAPVKFALLVAAISVAAGPATGASMNPARTLSPCFWNNSYHKIWIYFVGPPLAGVIMPIVYKYIFRREVSNVTEHISSPPQEQVCVCVVHNKESHFEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FGM4</accession>
    <name>A0A9I3FGM4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A9I3FGM4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015544-RA">
        <property type="protein sequence ID" value="AEPI015544-PA"/>
        <property type="gene ID" value="AEPI015544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039960922" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="39"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015544-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="575" mass="63683" checksum="BA4F3CCED19E28BC" modified="2023-06-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FGN8</accession>
    <name>A0A9I3FGN8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A9I3FGN8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015540-RA">
        <property type="protein sequence ID" value="AEPI015540-PA"/>
        <property type="gene ID" value="AEPI015540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08024">
        <property type="entry name" value="GH16_CCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000217">
        <property type="entry name" value="Gram-negative bacteria-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039897710" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="31"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015540-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="387" mass="43351" checksum="E4C93693B548EC2B" modified="2023-06-28" version="1">MRLGLIVFGMLVIGALADPDPGCAISLTTASGSRAKPGPYCSWDLIFEDNFNTLDFETWEHENTLSGGGNWEFQWYQNNRSNSYCENGIFYIRPTLLSDDTGEAFLSSGTLNIHGSEPANQCTSPMYFGCERTGTPTNLINPIKSARVRTVNSFSFKYGTMEVRARMPTGDWLWPAVWLLPKRQVYGTWPASGEIDLLESRGNLDYRGSNGMHIGVEQFGSTLHFGPSPTLNGWETTSVYKNTPAGQGWNTGFYNYQMTWTPDYIRFSVDNQLVTQIDAGTGFWNRGNFGNIAPGTENPWIHGTRMAPFDQEFYIIMNLAVGGTNGYFPDVPPATNGNRGKPWTNTSPTAARDFWNGRTTWLPTWRMTDNRGKDSSLQIDHVRVWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZD9</accession>
    <name>A0A182NZD9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZD9"/>
    <dbReference type="STRING" id="199890.A0A182NZD9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000019-RA">
        <property type="protein sequence ID" value="AEPI000019-PA"/>
        <property type="gene ID" value="AEPI000019"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000019"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000019-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="261" mass="28522" checksum="C60BD4F2E9BAE1A4" modified="2016-09-07" version="1">MVTHRKPPFYRMCNDATLRRLPIFAVLFLNLFIDLTTIDGHVLPRPLVTSSITTTVTTTTTIPSAGDISVEHNFSTAGSENIGSITSASPSRSVPFDVSILSGISAIGSHASSVSSASESTEAGNQHTGTETYSATLNNTASGRVLVVVPENFAIGQLHQGFRNFVKLLHTNRSSVVSDSSDENDENDDIGDATLLDSLIQFRSWRDMVAFERWLEDPAFTTVLYMSDEGDSFIGYCDSLSTHLSAIYRKSVLFWPCPRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZV5</accession>
    <name>A0A182NZV5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZV5"/>
    <dbReference type="STRING" id="199890.A0A182NZV5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000186-RA">
        <property type="protein sequence ID" value="AEPI000186-PA"/>
        <property type="gene ID" value="AEPI000186"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000186"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21341">
        <property type="entry name" value="TTC8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000586">
        <property type="entry name" value="Bardet-Biedl syndrome 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028796">
        <property type="entry name" value="BBS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000186-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="478" mass="52986" checksum="22FA1C624852F7C0" modified="2016-09-07" version="1">MDNFFAAISLFRRRKYDECIEVCNGLLQQNALHQGPWELKMRSMTQRVYIDDIEADDDVAEDILDTQTIATAPRPGTSIRTAIAKPSTSATNATANRPRTGTGRPITGISRPGTLSLQRPASTLGNKTALKTGSRTAAGTTAGGSARNIRLGSASMFAVGDPTGPLFHISRLHPDKYAERDALSKPLFQYLYYHEGDVRKAMALCDAVLARRRTAELLTDVSSGWWWNTQKARCLIAIGSPREAEPYLRIALQDLHHPDVVLLLARIYVKIDQPTAALEVCKQGLEKQPNEIALLTQQARILELVGNLTTSVRRYRQISALDPMNTEALACIAVSYFYANQPETALLYYRRILSMGAHSAELYCNIGLCCLYGGQLDLVFPCFQRALRMATVSELRADVYYNLSFVAMTTGDIHLARRCLRLCIAANGSHASALNNMAVLVARQKQYQKAKSYLQAARTAHPTSEEIGHNLKFIENFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0I0</accession>
    <name>A0A182P0I0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0I0"/>
    <dbReference type="STRING" id="199890.A0A182P0I0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000412-RA">
        <property type="protein sequence ID" value="AEPI000412-PA"/>
        <property type="gene ID" value="AEPI000412"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000412"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422:SF9">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000412-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="492" mass="55389" checksum="EA2AF37273C51057" modified="2016-09-07" version="1">MLNEEVDDTEFFQQDFTTASDWELFNARLEEIFHEWKLSFGQNSFRKLAHHELASCRWNVARETIKFADVELQVTHYRALLEAEPTEEAEPSEPVSGCQTFEDLMSIENDYCVAYSGQRSVSEDDQKLHPLAQWYGLREFVIVSPVKKSISNESQIRILMSSVHIAVSESSCDVPVFVQAMDKVQHVYLGVCESGPVRMSFDIVHLHLTPPTCKYLSGLLEVFKGKIGVAYVDPVAVSVRFTYQLARFLSGSFTSDKSLPFTENWTSDTVSLPFGVSIDPVGELIVHCTWPQVADNVVVDSQTYSDFDPLTAPLWSLRAQFEDTPVCYLADCLQEYLQISDSRRALTEYFSELAFGANVPPIEGENPLDLLTESKIPSLSSVLPTRIGASKTAPTKLEGPLNDEQLKDMLYYLFPDAQRDARWPYAPSVTGPAEFDPMRIKSANPDSLVHRLATLLALCNACFGGKRAVAQLWAEFAQEMRYRVERCIQIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0L3</accession>
    <name>A0A182P0L3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BtpA family membrane complex biogenesis protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0L3"/>
    <dbReference type="STRING" id="199890.A0A182P0L3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000445-RA">
        <property type="protein sequence ID" value="AEPI000445-PA"/>
        <property type="gene ID" value="AEPI000445"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000445"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04722">
        <property type="entry name" value="TIM_phosphate_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
        <property type="entry name" value="BtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00259">
        <property type="entry name" value="thylakoid_BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381:SF3">
        <property type="entry name" value="SGC REGION PROTEIN SGCQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381">
        <property type="entry name" value="ZGC:162297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03437">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005956">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000445-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29100" checksum="E3CA53B5700F1456" modified="2016-09-07" version="1">MEEPRPGGTALLITVTPMPGTPLYKGSVDKLVREVRAEANIYSKCGVDGVLVENMHDIPYIRPKDGIGPEITSTMTRVALAVREMLPDIPCGVQILAGCNREAMAVAKACQLQFIRAEGYVFGHMADEGFTDACGGSLLRYRKQIDAEDVLVLTDIKKKHSSHAITSDVSIAETASAAEFFLSDGLIVTGSSTGSTAELSDLQALRGKVNLPIIIGSGLTLGNLAEYWTLAHGAIVGSHFKESGHWSAPLCQKRVQTFMERAEALRCEPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0X1</accession>
    <name>A0A182P0X1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0X1"/>
    <dbReference type="STRING" id="199890.A0A182P0X1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000553-RA">
        <property type="protein sequence ID" value="AEPI000553-PA"/>
        <property type="gene ID" value="AEPI000553"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000553"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF1">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130619" description="EB domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="581"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="680"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000553-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="78429" checksum="A24F4473C9E5B7AF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1P9</accession>
    <name>A0A182P1P9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1P9"/>
    <dbReference type="STRING" id="199890.A0A182P1P9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000831-RA">
        <property type="protein sequence ID" value="AEPI000831-PA"/>
        <property type="gene ID" value="AEPI000831"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000831"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF60">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000831-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="70" mass="8096" checksum="3FEF57E2B24620FF" modified="2016-09-07" version="1">MLYLSAAQLVYKLDIMPNIIAMGFPAGNVEAIYRNNREDVLKLLTEKHGNNYKVYNLCSERTYDPKVFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1S4</accession>
    <name>A0A182P1S4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1S4"/>
    <dbReference type="STRING" id="199890.A0A182P1S4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000858-RA">
        <property type="protein sequence ID" value="AEPI000858-PA"/>
        <property type="gene ID" value="AEPI000858"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000858"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000858-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="255" mass="29288" checksum="E3B6BD1409E8A5CF" modified="2023-06-28" version="2">MVDYYKVLEVSRTASEAEIKKAYKKLALRWHPDKNMDNPEESNRRFKEISEAYEVLSDEKKRRIYDQYGKDGLMNNGSDRYHQSTRHRRHNGSNGMDDFEFFGFPFTFRDPEDVFREFFGGSPFDELFRISQPVHQHGGRRANGATNGHHHHHQRHSHPQNVISSPFMTPLMSFSLMDDFFSGAPRGGMTSVSEYTMGGGAPVKRTSTSTTFINGKKLMTKKVYENGTETIMSYENDVLKSKTVNGVAQAIPYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1Y7</accession>
    <name>A0A182P1Y7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1Y7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000921-RA">
        <property type="protein sequence ID" value="AEPI000921-PA"/>
        <property type="gene ID" value="AEPI000921"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000921"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130726" description="EXPERA domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000921-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21071" checksum="F74C12F96F3D624C" modified="2016-09-07" version="1">MLGMLWRSPFFGAFLLSILLVVRGEGSIMSLCSNIKFHGYLIVVFSALLTISVLISSVTLKLLYPDRRDEDIPNDFQDLIDYGWFDFVGDTVHLISIGVLFYGIRKENRFCLIPFMLSIVFDWIAYLIESTRNGSAMPYQVWLVTTALFLYVFVTLIGLFKFFQIKLKEGTDRSDEFNKTICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2R6</accession>
    <name>A0A182P2R6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2R6"/>
    <dbReference type="STRING" id="199890.A0A182P2R6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001201-RA">
        <property type="protein sequence ID" value="AEPI001201-PA"/>
        <property type="gene ID" value="AEPI001201"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001201"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="12">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001201-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="54943" checksum="405A77B07EE9D5B4" modified="2016-09-07" version="1">MNIENGTVALAYRQLCRLCLGREGELVDMFAVQQTAHQAEPLAVRIQGCLQLDITQHDTLPKWICKQCLDKIDDFTSFRERCKQNERKLLLGAEEPPVTKDADHETGDVEEQTDDEEEEEMEMIVIDPSRDYESSNDSLSSEVVRGEENGTDPYRPAMVGEQREPHPAEEEEAEGSEAEEGEEEEEEEEDEELKCDTAPGGDAQNGLTPYAGNANAAPRKTVVFTCKYCDHASCIRCGAVYTQKDKLYDHERYCMGKPPMFGLAAVGTLLEPPKQDVPLGGLGLPAQNNPPQPPPMLVPEPTHVEAIAVDQPNYTAAVNTPQTPPSSKIYNCTKCPKRFLSKASLRAHQSIHPAEVDTRMYECTQCRKQIVGKRSFDRHLQTHNELKAFGCATCGKRFSRRDKLRRHERIHQHTDRQFTCPNCSAKFVRKDAYESHLKIHCNPAMFGDPTGQEMTMMPMALQQQQHSLLYSMIGAANDDGTMKDPSIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2W8</accession>
    <name>A0A182P2W8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2W8"/>
    <dbReference type="STRING" id="199890.A0A182P2W8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001254-RA">
        <property type="protein sequence ID" value="AEPI001254-PA"/>
        <property type="gene ID" value="AEPI001254"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001254"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="94"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="9">
        <location>
            <begin position="402"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001254-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="86101" checksum="3B79D270C36DF26F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P318</accession>
    <name>A0A182P318_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182P318"/>
    <dbReference type="STRING" id="199890.A0A182P318"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001306-RA">
        <property type="protein sequence ID" value="AEPI001306-PA"/>
        <property type="gene ID" value="AEPI001306"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001306"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="5">
        <location>
            <begin position="123"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001306-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="314" mass="36259" checksum="5A00564A25E08F74" modified="2016-09-07" version="1">MNVKGSESNRDRFPKQKAYNLGDVVTDTAKTLTESELAQLEEQNKRLVTPFQALKLEQEARKHWDLFYKRNENRFFKDRHWTTREFSELLAGEESAGGVASSTHANVQSDQEPQGEKVDKTLLEIGCGVGNLIFPLIEDGHRDYFIYACDLSPRAVELVRKHNLYDERYMKAFACDITTEEVFETLTDASLDIVTLIFVLSAIHPEKFRSTVANIHRLLKPGGVVLFRDYGLYDMAQLRFKPGHKIAENFYMRQDGTRSYYFAEEEVSELFRQAGFTVLVNSYIHRRTINPKENIDVPRIFVQGKFQKPPTAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P375</accession>
    <name>A0A182P375_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P375"/>
    <dbReference type="STRING" id="199890.A0A182P375"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001359-RA">
        <property type="protein sequence ID" value="AEPI001359-PA"/>
        <property type="gene ID" value="AEPI001359"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001359"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000072">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF46">
        <property type="entry name" value="METABOTROPIC GABA-B RECEPTOR SUBTYPE 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
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    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
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    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130769" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="19">
        <location>
            <begin position="38"/>
            <end position="1096"/>
        </location>
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        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="20">
        <location>
            <begin position="558"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="888"/>
            <end position="931"/>
        </location>
    </feature>
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        <location>
            <begin position="888"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001359-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1096" mass="121767" checksum="3D06C6F89B97D5EB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P390</accession>
    <name>A0A182P390_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="7"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
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        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF155">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
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            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="932"/>
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        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1138"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1339"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
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        <location>
            <begin position="1330"/>
            <end position="1339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001374-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1371" mass="148619" checksum="5FAD013449262320" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3D0</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
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    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3D0"/>
    <dbReference type="STRING" id="199890.A0A182P3D0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001415-RA">
        <property type="protein sequence ID" value="AEPI001415-PA"/>
        <property type="gene ID" value="AEPI001415"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001415"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF31">
        <property type="entry name" value="SIDESTEP II, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="57"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="163"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="269"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001415-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="360" mass="41096" checksum="C1B67BB5E3324BF6" modified="2016-09-07" version="1">MASAKCTIKLAQRGIQCLCLTLVNLKRHDQGVYRCRIDFRTIQTQTYRYNLTVIVLPEQPVVLDRWGRHLNGTKLGPKEEGDDVVITCRVSGGRPQPEVRWLINGVIVDDQYEQNSGDVIENRLLWPTIQRSDLNAIFTCQTMNTKLVEPKETSYVLDMHLKPLTIKVINPPSTLVADKRYEIVCQSTGSRPNAIITWYKGKRQMRRTKDEILDHNTTTSTLSFAPTTEDDGKTLTCRAENPNVNGLFLETDWKMNVVYPPMVTIQLGPTLVVDDIKEGDDVYFECHVRANPDWKRLQWFHNDILLQYNGSARIIQSGQSLVLQKVTKQSAGYYACSAINAEGETVSDQQYLRVKRKCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3E9</accession>
    <name>A0A182P3E9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alkylglycerone-phosphate synthase</fullName>
            <shortName evidence="13">Alkyl-DHAP synthase</shortName>
            <ecNumber evidence="5 13">2.5.1.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57534"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:73315"/>
            <dbReference type="EC" id="2.5.1.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycerolipid metabolism; ether lipid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.26" evidence="5 13"/>
    <dbReference type="AlphaFoldDB" id="A0A182P3E9"/>
    <dbReference type="STRING" id="199890.A0A182P3E9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001434-RA">
        <property type="protein sequence ID" value="AEPI001434-PA"/>
        <property type="gene ID" value="AEPI001434"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001434"/>
    <dbReference type="UniPathway" id="UPA00781"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008609">
        <property type="term" value="F:alkylglycerone-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008611">
        <property type="term" value="P:ether lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025650">
        <property type="entry name" value="Alkyl-DHAP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568:SF1">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="6 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="14">
        <location>
            <begin position="113"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="145"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="214"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="279"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="12">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001434-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="586" mass="65409" checksum="985E92D31BD41660" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3N5</accession>
    <name>A0A182P3N5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P3N5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001520-RA">
        <property type="protein sequence ID" value="AEPI001520-PA"/>
        <property type="gene ID" value="AEPI001520"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001520"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22706">
        <property type="entry name" value="FHA_KIF13"/>
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        <property type="entry name" value="kinesin-like protein KIF16B isoform X1"/>
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        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
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        <property type="entry name" value="Kinesin_assoc"/>
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        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KINESIN_MOTOR_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="428"/>
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    </feature>
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            <begin position="1739"/>
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    </feature>
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            <begin position="789"/>
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    </feature>
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            <begin position="1364"/>
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            <begin position="1470"/>
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        <location>
            <begin position="549"/>
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        <location>
            <begin position="698"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1364"/>
            <end position="1373"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1378"/>
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        <location>
            <begin position="1491"/>
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            <begin position="1531"/>
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        <location>
            <begin position="1555"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1582"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1594"/>
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            <begin position="1633"/>
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    </feature>
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        <location>
            <begin position="52"/>
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        </location>
        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50006"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50067"/>
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        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001520-PA"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1826" mass="203353" checksum="B157AEEBDA5B0430" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3P1</accession>
    <name>A0A182P3P1_9DIPT</name>
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        <recommendedName>
            <fullName evidence="5 11">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="11">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
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        <text evidence="1 11">Required for normal Golgi function.</text>
    </comment>
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        <text evidence="4">Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Golgi apparatus membrane</location>
            <topology evidence="2 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COG6 family.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
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        <property type="entry name" value="COG6_C"/>
    </dbReference>
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        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="14">
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            <end position="626"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
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    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="484"/>
            <end position="515"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011166"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001526-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="628" mass="71317" checksum="628E4EB149465EAB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P405</accession>
    <name>A0A182P405_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P405"/>
    <dbReference type="STRING" id="199890.A0A182P405"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001641-RA">
        <property type="protein sequence ID" value="AEPI001641-PA"/>
        <property type="gene ID" value="AEPI001641"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001641"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000405">
        <property type="entry name" value="Galanin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF23">
        <property type="entry name" value="GALANIN-LIKE G-PROTEIN COUPLED RECEPTOR NPR-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00663">
        <property type="entry name" value="GALANINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="76"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001641-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="229" mass="25455" checksum="B0F69D96A7B79A7C" modified="2016-09-07" version="1">MTNDSRATPTEPPGQHHLLPMLMSDGTMSNSSWTELLNYTFENEALYHVNTSTIERIVSMMVPVFFGFIGLAGLLGNGLVVLVVAANQSMRSTTNLLIINLAAADLLFVVFCVPFTAVDYVLPEWPFGEYWCKFVQYMIVVTAHASAYTLVLMSLDRFLAVVHPITSMSIRTERNASIAICLTWFVILTTAIPVAISHGVLFYPRQGGYYTACLFLHNEGYSLVAFHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P407</accession>
    <name>A0A182P407_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P407"/>
    <dbReference type="STRING" id="199890.A0A182P407"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001643-RA">
        <property type="protein sequence ID" value="AEPI001643-PA"/>
        <property type="gene ID" value="AEPI001643"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001643"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000148">
        <property type="entry name" value="CLIP-domain serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000192">
        <property type="entry name" value="CLIP-domain serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130789" description="Peptidase S1 domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="169"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001643-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="413" mass="42669" checksum="C40DFC598045B4B4" modified="2016-09-07" version="1">MNSIRGLGLVLVIGSGFSVMALSTVERNPGFNFPQDGETPTPTDDLTRQGASNVNNGITSGVLTGVVPLQTGTTTGQTCICVPTGRCNTTTSGGTTDGAGQLDVRIVSNVNANTGVTLGTTTTTGTTLAPVITVNIVSPTTCQSGLERCCLAGSYQCGLQYPPIANSPAVAANQAAYGEYPWQVVLLGPGDVYVGSGVLIDNRHVLTAAHKISDYTSGSRTLKVRLGEWNAAATTEPLPVQEFTVARYFVHPNFNSANLRNDIAVLRLSGTVSLGTTPTIATACLPVTSFVGSRCWVSGWGKNDFVSGAFQSIPKEVDVPIVSAAACQTSLRTTRLGGNFVLDATSFICAGGELGKDACTGDGGSPLVCSLNNRWFVVGLVAWGIGCGANGIPGVYVNVASYNSWIQTTIATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P451</accession>
    <name>A0A182P451_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prospero domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="9">Epiroticus2</strain>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <source>
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</entry>
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            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4L1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001847-RA">
        <property type="protein sequence ID" value="AEPI001847-PA"/>
        <property type="gene ID" value="AEPI001847"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001847"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001847-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="18" mass="1922" checksum="88B0FCABCA2227CF" modified="2016-09-07" version="1">MWRSAAIPRSPNPPTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4L6</accession>
    <name>A0A182P4L6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4L6"/>
    <dbReference type="STRING" id="199890.A0A182P4L6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001852-RA">
        <property type="protein sequence ID" value="AEPI001852-PA"/>
        <property type="gene ID" value="AEPI001852"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001852"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001852-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="161" mass="14980" checksum="023B0E0EAC39493B" modified="2016-09-07" version="1">MDKSKKPPATAGGTGATGSGAAAPGGAGGAPGAGGPGKGPGGPAGAKGPGGKGPPKGKPSDSDAPGASGKAEGEPGSAKDDPSANGDKRSDKADTEQPSQPKPGSAGATVRDGAQKVLNLAMKSEWAPVEAVLKGLEKAVAAGGDDSNQTPLAGVLDPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4M6</accession>
    <name>A0A182P4M6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4M6"/>
    <dbReference type="STRING" id="199890.A0A182P4M6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001862-RA">
        <property type="protein sequence ID" value="AEPI001862-PA"/>
        <property type="gene ID" value="AEPI001862"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001862"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000025">
        <property type="entry name" value="luciferin 4-monooxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF353">
        <property type="entry name" value="GH16244P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="39"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="452"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="579"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="984"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001862-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1082" mass="119244" checksum="5FD29759580D9441" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P528</accession>
    <name>A0A182P528_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182P528"/>
    <dbReference type="STRING" id="199890.A0A182P528"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002015-RA">
        <property type="protein sequence ID" value="AEPI002015-PA"/>
        <property type="gene ID" value="AEPI002015"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002015"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
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    <name>A0A182P5A3_9DIPT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Epiroticus2</strain>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <strain evidence="2">Epiroticus2</strain>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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</entry>
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            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
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        <scope>IDENTIFICATION</scope>
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        <location>
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        <location>
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            <end position="107"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="Pfam" id="PF16064"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="827" mass="93917" checksum="CFAB31CCA93423EC" modified="2016-09-07" version="1"> </sequence>
</entry>
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    <accession>A0A182P5X1</accession>
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                <person name="Haas B."/>
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                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
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    <dbReference type="STRING" id="199890.A0A182P5X1"/>
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        <property type="protein sequence ID" value="AEPI002312-PA"/>
        <property type="gene ID" value="AEPI002312"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF1">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CONUNDRUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="352"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002312-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="584" mass="65266" checksum="CEC8892C1AD906AE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7B3</accession>
    <name>A0A182P7B3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7B3"/>
    <dbReference type="STRING" id="199890.A0A182P7B3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002815-RA">
        <property type="protein sequence ID" value="AEPI002815-PA"/>
        <property type="gene ID" value="AEPI002815"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002815"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF12">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="141"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002815-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="411" mass="46718" checksum="5A825C1533471CDC" modified="2016-09-07" version="1">MAETAQPEIKPATPPEWLNSAYLETVLRKSEGDKELHVTGIESTPVGKPGEYLASQLFRVTVHCQGAGRTGDTDGGSKKLVVKIQPDKGIVADTMDATLFKNELKMYGEFLPKMERLLADNERPLALPRCVHISEVPQPIIILEDLAPAGWKGHDLIESFEEVKPIAIAIARFHAATFYLSKNKTDFEEFQTDLFQKKHPVLEWMFGNNLKAFTESLRTWHGCEQYVEPFERSFADYCDRLHSIYSCKTAGRLYNVLNHGDFHAKNLLHQFNDEGGIVDSRFLDFQACCWSTPAIDLYYLLNNIVHYKVKAAHKEEILAFYHAEFTGTLKAVGYLGYIPTMLDLQIELLRNGFLDILHYTCFLQFRFIDFTKIDPEKLATGQVGNAGLENEDYRTLMKSLIPGYVHKGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7H6</accession>
    <name>A0A182P7H6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-Cys peroxiredoxin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [protein]-dithiol = [protein]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:10008"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7H6"/>
    <dbReference type="STRING" id="199890.A0A182P7H6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002878-RA">
        <property type="protein sequence ID" value="AEPI002878-PA"/>
        <property type="gene ID" value="AEPI002878"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002878"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF3">
        <property type="entry name" value="DI01187P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002878-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="221" mass="24994" checksum="6648C46F0E7753B0" modified="2016-09-07" version="1">MRIGATIPNFQADSTKGPIDFYEWIGDSWCVLFSHPADFTPVCTTELGRIAVHQEHFEKRNVKVLAHSVDDLKCHVDWVNDIKSYCPDIIGNFPYPIIADPSRDLAVRFGMLDEKDKDNVELAQTVRALFIISPDKKVRLTMHYPTSTGRNVDEILRVIDSLQLTDRLKVIATPANWTPGTKVMILPSVSEEEADKLFPNGIERVSMPSGNVYVRTTTDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7Q9</accession>
    <name>A0A182P7Q9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7Q9"/>
    <dbReference type="STRING" id="199890.A0A182P7Q9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002962-RA">
        <property type="protein sequence ID" value="AEPI002962-PA"/>
        <property type="gene ID" value="AEPI002962"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002962"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002962-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="121" mass="13661" checksum="3B2EC147CAFA2B45" modified="2016-09-07" version="1">LSNIATTCCTCDSFGTVGAVDPKFSAPIANVTVPVGREGVMTCTVHDLYKYKVAWLRVDTQTILTIETLVITKSERISITHTEQRIWQLRIKDIRESDKGWYMCQINTDPMKSQMGYLDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8N6</accession>
    <name>A0A182P8N6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <ecNumber evidence="4">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182P8N6"/>
    <dbReference type="STRING" id="199890.A0A182P8N6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003289-RA">
        <property type="protein sequence ID" value="AEPI003289-PA"/>
        <property type="gene ID" value="AEPI003289"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003289"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.20:FF:000005">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="15">
        <location>
            <begin position="52"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="14">
        <location>
            <begin position="283"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003289-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="650" mass="71706" checksum="6AB1BD41242A0150" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9B0</accession>
    <name>A0A182P9B0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P9B0"/>
    <dbReference type="STRING" id="199890.A0A182P9B0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003514-RA">
        <property type="protein sequence ID" value="AEPI003514-PA"/>
        <property type="gene ID" value="AEPI003514"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003514"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003514-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="109" mass="12029" checksum="3B0BBB828EC15A71" modified="2016-09-07" version="1">MNLRLRTRLASYSVDPFDLSIVNQTGCPKEGEAGWNIHIDPDTFSTRNIANAFRKAGEAIGDGFEAAVNAGKKIYNNYRNGDSDETEAHVEETGTARSERLINAAEWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9C2</accession>
    <name>A0A182P9C2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Outer dynein arm-docking complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tetratricopeptide repeat protein 25</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9C2"/>
    <dbReference type="STRING" id="199890.A0A182P9C2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003527-RA">
        <property type="protein sequence ID" value="AEPI003527-PA"/>
        <property type="gene ID" value="AEPI003527"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003527"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040111">
        <property type="entry name" value="ODAD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23040:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003527-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="441" mass="49216" checksum="6C6A8AEDF377F699" modified="2016-09-07" version="1">MGMQRSNQRKMNKPANKKRQKGSKPVIDEIEVAGKNLRDEALKYMKVSLTNAKTALGILGGEDELLQSFVRVGLKTDGDDDQQQSNVTFSGGASGGGGGGSGSGAGAGGSGGNGPQTVTIQHQASQGKLDTHLIRQFSDHCSDMSDKNAPRKYRDLFNEPVDIKKRRYFDEVYTDKDRAAAVSIGKAKRNFDIKQNLINKRRQERNEALQTEEAEPGAILALGMREIKNGNLDNAALEMNNNDQNALVARSRCFLQLGEPGKALQDAETALVLDKNNIRAIYQKAEALYYLGQFEHSLMFFHRGLRLRPELASFRLGVQKTQEAIENTIGNNTKNQPQKKPAKVEKPKTAKRNQLSREELEKRASRRLLGDLYIDKEYLENLIKHPDLRKADTNTEGVSEFAKDAINFLNNRQEFWRQQKPCTSLNAKKISGANGMLPRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9S0</accession>
    <name>A0A182P9S0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9S0"/>
    <dbReference type="STRING" id="199890.A0A182P9S0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003674-RA">
        <property type="protein sequence ID" value="AEPI003674-PA"/>
        <property type="gene ID" value="AEPI003674"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003674"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003674-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20394" checksum="422838EEBC1381EC" modified="2016-09-07" version="1">MAANVQQSGNLLDVLKKKMRQTKEEMEKYKDECEEFHKKLQNEVMRREEAESEVAALNRRIQLLEEDLERSEERLASATAKLSEASAAADESERIRKALENRTNMEDDRVAILEAQLAQAKLIAEEADKKYEEVLENRALADEERMDALENQLKEARFMAEEADKKYDEVQTLDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9W2</accession>
    <name>A0A182P9W2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-related protein Rab</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9W2"/>
    <dbReference type="STRING" id="199890.A0A182P9W2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003716-RA">
        <property type="protein sequence ID" value="AEPI003716-PA"/>
        <property type="gene ID" value="AEPI003716"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003716"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04107">
        <property type="entry name" value="Rab32_Rab38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000222">
        <property type="entry name" value="RAB32, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030697">
        <property type="entry name" value="Rab29/Rab38/Rab32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF39">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003716-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="957" mass="101827" checksum="A49396FF844A9653" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAB6</accession>
    <name>A0A182PAB6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAB6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003870-RA">
        <property type="protein sequence ID" value="AEPI003870-PA"/>
        <property type="gene ID" value="AEPI003870"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003870"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003870-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="116" mass="12559" checksum="4A778B9C3A6D2E01" modified="2016-09-07" version="1">MSVRWQSPEVGQRRRSGGSVDECEISMLAADGGATMTTDDDGDHSRSRNGGVRDGHRTEQADRIASGGRCPVARVDVDLSDEEESALEQDDTDEIVVLDEASERLLGKWNGNAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAH5</accession>
    <name>A0A182PAH5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PAH5"/>
    <dbReference type="STRING" id="199890.A0A182PAH5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003929-RA">
        <property type="protein sequence ID" value="AEPI003929-PA"/>
        <property type="gene ID" value="AEPI003929"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003929"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
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            <dbReference type="ARBA" id="ARBA00079255"/>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003929-PA"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1141" mass="120414" checksum="2D5606F30215AD33" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBH2</accession>
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        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
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    </organism>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
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        <property type="entry name" value="Scoloptoxin-like"/>
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        <property type="entry name" value="FI18455P1-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CBM_14"/>
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        <location>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5008131173" description="Chitin-binding type-2 domain-containing protein" evidence="2">
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004277-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="772" mass="83394" checksum="E7400AAD7E35BF93" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC17</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="2">WD repeat-containing protein 79</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCAB1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC17"/>
    <dbReference type="STRING" id="199890.A0A182PC17"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004473-RA">
        <property type="protein sequence ID" value="AEPI004473-PA"/>
        <property type="gene ID" value="AEPI004473"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004473"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030576">
        <property type="term" value="P:Cajal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004473-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="427" mass="47502" checksum="B11089AA5CA22638" modified="2016-09-07" version="1">MNQDETVELENGTEIDKEADEEQEIPMQTEDAASEAECAQVTEESAFFKDSACIEVARCSWDRPVRQNYLQGCRWSPDGTCVLTAVNNDGMHIVELPTDLYGKQHVPEDRPVDLLTPAVHVKEGGLVYDYAWYPRMNSGQPETCCWVASRQHEPIQLWDAFTGILRCSYKGYDQFDEVEAALSLAFGPTDGAIIYGGYKKSIKSFDINVPGRESSSWRTKSTASCMAIASSMPDTILFGSWNRSITALDVRSGECLPVGNYAPANSHIAGVTWIAFAPDTEELFVTGARKDPKLLLWDVRKLTQPVQTLVRTCGTNQRIYFDFSPGGRWLISGDTRGILHAWNLHETDGEGQPKELLFPLHWDCLNGVSFHPHGPIMATASGQYHFPHSAVEDDEVTPTIAAADVKVPKMENSLTLWWIGKGVFSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC67</accession>
    <name>A0A182PC67_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">EH domain-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC67"/>
    <dbReference type="STRING" id="199890.A0A182PC67"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004522-RA">
        <property type="protein sequence ID" value="AEPI004522-PA"/>
        <property type="gene ID" value="AEPI004522"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004522"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21198">
        <property type="entry name" value="CH_EHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000023">
        <property type="entry name" value="EH domain-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022735">
        <property type="entry name" value="bMERB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF46">
        <property type="entry name" value="EPS15 HOMOLOGY DOMAIN CONTAINING PROTEIN-BINDING PROTEIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12130">
        <property type="entry name" value="bMERB_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01203">
        <property type="entry name" value="DUF3585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51848">
        <property type="entry name" value="BMERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="462"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="BMERB" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="846"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="887"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="742"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004522-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1084" mass="120483" checksum="DC4E3EAF00D63F6D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCM4</accession>
    <name>A0A182PCM4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCM4"/>
    <dbReference type="STRING" id="199890.A0A182PCM4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004679-RA">
        <property type="protein sequence ID" value="AEPI004679-PA"/>
        <property type="gene ID" value="AEPI004679"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004679"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000053">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004679-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="540" mass="59007" checksum="F631944E70C55254" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCR5</accession>
    <name>A0A182PCR5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCR5"/>
    <dbReference type="STRING" id="199890.A0A182PCR5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004720-RA">
        <property type="protein sequence ID" value="AEPI004720-PA"/>
        <property type="gene ID" value="AEPI004720"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004720"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15728">
        <property type="entry name" value="FYVE_ANFY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000104">
        <property type="entry name" value="Ankyrin repeat and FYVE domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000628">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049764">
        <property type="entry name" value="ANFY1_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141:SF1">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="494"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="595"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="630"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="663"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="769"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="830"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004720-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="896" mass="97559" checksum="8B5D7A721CBAE9B6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCZ4</accession>
    <name>A0A182PCZ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine O-palmitoleoyltransferase porcupine</fullName>
            <ecNumber evidence="9">2.3.1.250</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[Wnt protein]-L-serine + (9Z)-hexadecenoyl-CoA = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA</text>
            <dbReference type="Rhea" id="RHEA:45336"/>
            <dbReference type="Rhea" id="RHEA-COMP:11170"/>
            <dbReference type="Rhea" id="RHEA-COMP:11171"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:85189"/>
            <dbReference type="EC" id="2.3.1.250"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the membrane-bound acyltransferase family. Porcupine subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.250" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A182PCZ4"/>
    <dbReference type="STRING" id="199890.A0A182PCZ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004799-RA">
        <property type="protein sequence ID" value="AEPI004799-PA"/>
        <property type="gene ID" value="AEPI004799"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004799"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990698">
        <property type="term" value="F:palmitoleoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061355">
        <property type="term" value="P:Wnt protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF12">
        <property type="entry name" value="PROTEIN-SERINE O-PALMITOLEOYLTRANSFERASE PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004799-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="439" mass="50269" checksum="E0217CDA1F283919" modified="2016-09-07" version="1">MDYYYDDYYDEYYDHPDQLAARILQRDLSMEETIKNCVHPSIRFATQYITNFIAINLLFSILVLLSRYTPCNGHFIDGYPELADTELLEPSPDTWNRIRGTQMILLMKALSLAFDTEENHSLRSQLGVLSYSGYILCPANIILGPWIAFSDYLTIWKVSSGIEPKHSRPSSPGRRILIHVFRVVVSALMAVGFLLTSNCMIDYLLAPIASWKWVQAYGKALAFRTSHYFIGYLSQCSMIAAAVDWNRAEDERSMMLPVSSLYRVTSPTAVEFPRSLVQVVTAWNIPMHLWLKRYIFRTTKRPFGTATAIALTYIISSLLHGLHYRLWVTLLTIGSWTFVEHELRKKLATIYSACVLVGKCPDTCPAHQHKRNSLFSIVINSLFFALNAFNLTYLGCIFDSSEGPPDEAHQEKSLFGGWAELNYASHWLLVFAYLFYFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD89</accession>
    <name>A0A182PD89_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malate dehydrogenase</fullName>
            <ecNumber evidence="11">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182PD89"/>
    <dbReference type="STRING" id="199890.A0A182PD89"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004894-RA">
        <property type="protein sequence ID" value="AEPI004894-PA"/>
        <property type="gene ID" value="AEPI004894"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004894"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01336">
        <property type="entry name" value="MDH_cytoplasmic_cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000010">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000014">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011274">
        <property type="entry name" value="Malate_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01758">
        <property type="entry name" value="MDH_euk_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003916">
        <property type="entry name" value="PRK05442.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="157"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004894-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="334" mass="35997" checksum="B192B9710FC34D7D" modified="2016-09-07" version="1">MSAEPIRVVVTGAAGQIAYSLLYMVAKGDVFGPNQPLILHLLDIPPMMGVLEGVVMELDDCALPLLVRVVPTADPAVAFKDVDAAFLVGAMPRKQGMERKDLLSANVKIFKVQGEALDKYAKKDVKVLVVGNPANTNALVCSHYAPSIPKENFTAMTRLDQNRAQAQIAGRLGVGITKVKNVIIWGNHSATQVPDARNASVEVNGAVKTVPEAVADDEFLKQQFLETVQKRGAAVIAARKMSSAMSAAKAASDHMRDWFAGTRDGEYVSMGVISDGSYGAPKDIVFSFPVQIQNRQWKIVQGLSVDEFTRGKLDITAKELLEEKEEAMAVCAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDK8</accession>
    <name>A0A182PDK8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDK8"/>
    <dbReference type="STRING" id="199890.A0A182PDK8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005013-RA">
        <property type="protein sequence ID" value="AEPI005013-PA"/>
        <property type="gene ID" value="AEPI005013"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005013"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131185" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005013-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="75" mass="7851" checksum="083BAA1D0A9EB2E7" modified="2016-09-07" version="1">MLPASPHSSVAAASVRMVMMLLVLVPLLPLPGAVLGDYENSWNSYYEQPCCGGSTNGPFHLRHHGAGVSTGAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDZ0</accession>
    <name>A0A182PDZ0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDZ0"/>
    <dbReference type="STRING" id="199890.A0A182PDZ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005145-RA">
        <property type="protein sequence ID" value="AEPI005145-PA"/>
        <property type="gene ID" value="AEPI005145"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005145"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005145-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="69711" checksum="9940ECB4F4131E12" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEJ3</accession>
    <name>A0A182PEJ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEJ3"/>
    <dbReference type="STRING" id="199890.A0A182PEJ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005348-RA">
        <property type="protein sequence ID" value="AEPI005348-PA"/>
        <property type="gene ID" value="AEPI005348"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005348"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000007">
        <property type="entry name" value="Alkaline nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF19">
        <property type="entry name" value="NUCLEASE EXOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="6">
        <location>
            <begin position="126"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005348-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="391" mass="43765" checksum="C49CB86D503FAF0E" modified="2016-09-07" version="1">MDKDLTSCTISLHRDLTALQPLLLQPGTDQFLWPQRNSTIIALDGGQSVELFCSHGFRKGSPAGKDKSATITCEDDGMLGYRADQYNISQFLCQRAVYHVAERTGARCHDNGTIVRVGFSVDVDRFAKLYELCFDETTLRTHYVKHQLTPHNDHHQRAVKRPSFLQGGFYDGLKMATLYSFAGQHATLARILSSPARANAVLSSKKGLFFARGHLAAKSDFVFGAHQRASFWFMNVAPQWQRFNGFSWQRIETSVKAYVAANDLRLTVYTGTYGVLKLLDGNGDGQEIYLDFDANRDPPGRVPAPALFYKVLLDEEHDAGLAVVGVNNPYATPEEIASEYVVCEDVSGAVRWLRWDRNTIDDGYVYACDVNEFNRVTGHLVLDRPVGRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFD4</accession>
    <name>A0A182PFD4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PFD4"/>
    <dbReference type="STRING" id="199890.A0A182PFD4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005640-RA">
        <property type="protein sequence ID" value="AEPI005640-PA"/>
        <property type="gene ID" value="AEPI005640"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005640"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000025">
        <property type="entry name" value="serine/threonine-protein kinase ULK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF65">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ULK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MIT" evidence="12">
        <location>
            <begin position="68"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="MIT" evidence="12">
        <location>
            <begin position="200"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="141"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005640-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="292" mass="32807" checksum="FC9AD4A7743ECA6B" modified="2016-09-07" version="1">MSEAKITEYKLLERLGSGTYAIVYRAMKKTTKEILALLASLLQRDPARRITFEKFFDDPYLDLAHVACEENLEKAIALINRAIEMEQRQELGAAYRAYCQGLQYFVPITRAEPDPAKRQLLRQRVLTYLNRAEALKQHVYAASQREHRPPEVPPKVPPGEKERISRKVITGSSTDGGGRGVGETAEQTPSEPGIAELARDHESIARGLEIGRQAAKEASENKLDAALDSYTSALGLLIPVLHQDIAPGQKRLLRQRVVQWMEEAEQIKSIRSAQIMQEMESTEANHYACTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFG0</accession>
    <name>A0A182PFG0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dihydropyrimidinase</fullName>
            <ecNumber evidence="7">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="8">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A182PFG0"/>
    <dbReference type="STRING" id="199890.A0A182PFG0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005667-RA">
        <property type="protein sequence ID" value="AEPI005667-PA"/>
        <property type="gene ID" value="AEPI005667"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005667"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006208">
        <property type="term" value="P:pyrimidine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000076">
        <property type="entry name" value="Dihydropyrimidinase like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000217">
        <property type="entry name" value="Dihydropyrimidinase-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="71"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="399"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="8">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005667-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="665" mass="73293" checksum="FD7D1CBE49D90C62" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGC1</accession>
    <name>A0A182PGC1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 9">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 9"/>
    <dbReference type="AlphaFoldDB" id="A0A182PGC1"/>
    <dbReference type="STRING" id="199890.A0A182PGC1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005980-RA">
        <property type="protein sequence ID" value="AEPI005980-PA"/>
        <property type="gene ID" value="AEPI005980"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005980"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005980-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="558" mass="62426" checksum="2F344CAE6FAA2D04" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGF6</accession>
    <name>A0A182PGF6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 200A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM200 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGF6"/>
    <dbReference type="STRING" id="199890.A0A182PGF6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006015-RA">
        <property type="protein sequence ID" value="AEPI006015-PA"/>
        <property type="gene ID" value="AEPI006015"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006015"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018787">
        <property type="entry name" value="DUF2371_TMEM200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815">
        <property type="entry name" value="AGAP005329-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 200C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10177">
        <property type="entry name" value="DUF2371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="644"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="712"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="723"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006015-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="82915" checksum="DD56B7D04AC3507E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH15</accession>
    <name>A0A182PH15_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-phosphoinositide-dependent protein kinase 1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="STRING" id="199890.A0A182PH15"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006224-RA">
        <property type="protein sequence ID" value="AEPI006224-PA"/>
        <property type="gene ID" value="AEPI006224"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006224"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01262">
        <property type="entry name" value="PH_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000191">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000405">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000587">
        <property type="entry name" value="Phosphoinositide-dependent kinase 1, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000324">
        <property type="entry name" value="Phosphoinositide-dependent kinase 1, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="19"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="167"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="394"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="637"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1271"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1283"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006224-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1297" mass="145817" checksum="AAECAF494E130E51" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHE5</accession>
    <name>A0A182PHE5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 18</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHE5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006354-RA">
        <property type="protein sequence ID" value="AEPI006354-PA"/>
        <property type="gene ID" value="AEPI006354"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006354"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026721">
        <property type="entry name" value="TMEM18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22593">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22593:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14770">
        <property type="entry name" value="TMEM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006354-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="148" mass="17427" checksum="9CB503F2EADEE688" modified="2016-09-07" version="1">MVDPTWIEINEIKGFITFLSSIDWYDPWLIGLIAFHVCITSTALLTRNYGNFQVFLFFVLLLLVYFSESINEYAAINWRIFSKQQYFDDKGLFISVVFSVPILLNCMLMVGSWLYQSTQLMSKLKTAQLKQQIRQSNSRQRLKDDKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHN6</accession>
    <name>A0A182PHN6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear hormone receptor FTZ-F1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHN6"/>
    <dbReference type="STRING" id="199890.A0A182PHN6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006446-RA">
        <property type="protein sequence ID" value="AEPI006446-PA"/>
        <property type="gene ID" value="AEPI006446"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006446"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016355">
        <property type="entry name" value="NR5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086:SF15">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FTZ-F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006446-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28091" checksum="452BB14184D03A28" modified="2016-09-07" version="1">MRGGRNKFGPMYKRDRARKLQIMRQRQLALQALRGSIGGGVGIGTLGSEGVSPQLQGLDYHQPYSSMHIKQEIQIPQVSSLTSSPDSSPSPIAIALGQVNPQTTISLSSSGVGGNGGGGGGGGGGGGGGGGSNGSGAGTGSSNSNSATNIQNPLSDSKLWMSANSTTASPHSLSPKAFSFDSNPTSTADSGNPADTLRLVVSPMIREFVQSIDDREWQTSLFSLLQSQSYNQCEVDLFELMCKVLDQNLFSQVDWARNTIFFKDLKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHQ3</accession>
    <name>A0A182PHQ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHQ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006463-RA">
        <property type="protein sequence ID" value="AEPI006463-PA"/>
        <property type="gene ID" value="AEPI006463"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006463"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953:SF1">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006463-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="51446" checksum="F78A30596B2FFC1A" modified="2016-09-07" version="1">MEGEVRFVMDRANDLEEQLAPGYQKAFTSNLPTVTRPMLWEYMLRLMKAMSGNDSHLKALQSCAENNPEYGDDSVGYVQLRREDSYCTVKGQIHSIGPCDDGENTEIKIHQLTVTIDEEHHKVESVACSDCAELEFCQHTTSFLLWLHTQDQPGTHQDVECFFRTPLATELEQIPVKPLVNKTKTKNFIREIVHGLQTEDIDCPLRWNFSSVNKKFSNLSIHELIICAVKNRYSVAQFFEHAQAVVASASGVLADKVKFQPRSSPWFQELRYGRISGAKVYECTQPNVSPTLLHEKILGCNKEIDSQLQRKKLAIRQRLEKFTKKTYENPRITMNSSFPIIFNVPDGVSPQHVVEIKCPRTRETLNKYVTPDGSLQEKYYLEMQVHMLMYGATSGMVCVADPNFETNNELYMHSFNLNKPFVMKKLQKALEYWENHVFPELMANWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIN1</accession>
    <name>A0A182PIN1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIN1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006793-RA">
        <property type="protein sequence ID" value="AEPI006793-PA"/>
        <property type="gene ID" value="AEPI006793"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006793"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131319" evidence="2">
        <location>
            <begin position="27"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006793-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="269" mass="30295" checksum="CFDA03DEBF300492" modified="2016-09-07" version="1">MGARVVASFLLLGLVALALTTPLTSGYELTLEAELETGIKDWSCKSYCNNCNCTAEYIPDENVCLCYCPNPAEKTSCFQFVRETNNILGIEYDLQVRDAARSVVGVQRTKRDTPKAERKARRKERIANRKLGKKRHLNKLCLMALSIALVISSARADDIITVDESECNIKPTVISCEKNKLSYSVVVQDSHGDQIVFNHNIERIPATKPPRPTRRRKSGASRAERVGSFRTLLQDKAAALKEKMAMLIAKRRAKFRRQRIRANSRARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIV5</accession>
    <name>A0A182PIV5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein MEAF6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIV5"/>
    <dbReference type="STRING" id="199890.A0A182PIV5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006868-RA">
        <property type="protein sequence ID" value="AEPI006868-PA"/>
        <property type="gene ID" value="AEPI006868"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006868"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="96"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006868-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="246" mass="25963" checksum="F59EF019D69DBF0B" modified="2016-09-07" version="1">MSTKSSNSIDSRTELADLVKRKAEISETLANLERQIYAFEGSYLEDTQLYGNIIRGWDRYLTTNKTTNSKADKRNRKFKEAERLFSKSSITSMAAVSGLADTSDTKHERNSESDSMTNDDSSDNQAGGTHSSVNHSSSAGIREPSTNSGSVAGSAAAGATDGALKNSSNKSLASQSKANSVDKASSGGAFLNRATTPTKESTNSTSSVAKESATNSSSTPSGTAKHKASNIGSMKKGSSNKKVRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJI6</accession>
    <name>A0A182PJI6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJI6"/>
    <dbReference type="STRING" id="199890.A0A182PJI6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007100-RA">
        <property type="protein sequence ID" value="AEPI007100-PA"/>
        <property type="gene ID" value="AEPI007100"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007100"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070920">
        <property type="term" value="P:regulation of regulatory ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051247">
        <property type="entry name" value="RLC_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205:SF4">
        <property type="entry name" value="LD06392P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="110"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007100-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="322" mass="36687" checksum="972F8BEA62F892FC" modified="2016-09-07" version="1">MSKAEILKDKMPVTVLQEIAHKSKLPLPMYQFIGEEVSPLNSNVKTFTYVVMALGKKATGVGRSKQEAKHEAAWQLIRLALELPPDEEDEMVATAAEERGSLAALELGMDRVSQVRDICIQRNFPLPEFELVRNYGPSHAPVFEYECRIREIVRRGSHSTKKGAKQIACQEMIKTLQSMPVEDHGMQMLSLDQAINEVEENEENVIRSYREYTQSDNKKKLGVTIADRHRFFLELPQERIDDARQLLLNETETIQEKCYRIAQVLGLKAKITIANSNILTTNGGAMNTFELINPDYDCFIAGIGETFFKNVYEYFLCMLNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJL4</accession>
    <name>A0A182PJL4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJL4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007128-RA">
        <property type="protein sequence ID" value="AEPI007128-PA"/>
        <property type="gene ID" value="AEPI007128"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007128"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF46">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 99A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007128-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="245" mass="28061" checksum="960D49909FCC7439" modified="2016-09-07" version="1">MVLDCAELMSISPTKLSRIRSGLLVGDDETKCLIRCVGVSAGFWSDRTGLRKDLLAQYFVPHPTDDLNFNRTEACLKELPGSVSNPHDYCDLAFESFLCFYYNFGNLKQDSMFVPLDHLQLQHVTARCVEVHQLTKEQLTSLSEEAMDTNDNVHCLVRCIGLQTGVYSDREGVYLDLIYAQYGEGYCEEEYKRNAFECIKQQRGFAYGTSPSKRAYQLLYKCFENVRNVISAYELHDSVEDLFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJR1</accession>
    <name>A0A182PJR1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJR1"/>
    <dbReference type="STRING" id="199890.A0A182PJR1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007175-RA">
        <property type="protein sequence ID" value="AEPI007175-PA"/>
        <property type="gene ID" value="AEPI007175"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007175"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031114">
        <property type="term" value="P:regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="92"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007175-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="337" mass="38032" checksum="9AD43A3840B8E55E" modified="2016-09-07" version="1">MVNNGSDDGRSGPYRGYGNDNSNENSQEEEIDERLRNIDPKMVELIRSEIMDRFQPLSWDDIAGLEYAKTIIKEAVVWPILRPDIFTGLRKPPRGILLFGPPGTGKTLIGKCIASQSKSTFFSISASSLTSKWIGDGEKMVRALFAVAAVHQPAVVFIDEIDSLLCQRSDTEHESSRRLKTEFLVQLDGAATAEDERILIVGATNRPQELDEAARRRLVKRLYIPLPERSARIQILSRLLNRERNNLETEDIARIGDLTEGFSGADMKVLCHEASMGPIRCIPFEQLGDIAMDQVRPICYDDFRLALTKVKASVSQDDLQHRSWLYLQEEKETLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKE2</accession>
    <name>A0A182PKE2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKE2"/>
    <dbReference type="STRING" id="199890.A0A182PKE2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007409-RA">
        <property type="protein sequence ID" value="AEPI007409-PA"/>
        <property type="gene ID" value="AEPI007409"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007409"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000588">
        <property type="entry name" value="exportin-5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="3">
        <location>
            <begin position="113"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="4">
        <location>
            <begin position="314"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007409-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1236" mass="137885" checksum="3F0F4271A55F0046" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKN6</accession>
    <name>A0A182PKN6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKN6"/>
    <dbReference type="STRING" id="199890.A0A182PKN6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007503-RA">
        <property type="protein sequence ID" value="AEPI007503-PA"/>
        <property type="gene ID" value="AEPI007503"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007503"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007503-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="115" mass="11866" checksum="571846FC3F0B4CAE" modified="2016-09-07" version="1">MSSEEDKPPAPPVRLTSNRGGGGGGGVVGGGGGGSGVVDRIDGVAPVDMKPLPKEPEDADRKKKTLKNKIKVSKASHNDSKPNISYPTNFEHTVHVGFDAVTGEFTLAGIESNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL67</accession>
    <name>A0A182PL67_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PL67"/>
    <dbReference type="STRING" id="199890.A0A182PL67"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007684-RA">
        <property type="protein sequence ID" value="AEPI007684-PA"/>
        <property type="gene ID" value="AEPI007684"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007684"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007684-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="468" mass="51897" checksum="D16B936172D4EA68" modified="2016-09-07" version="1">MAAAQVEQQLPLAPDTKIVKAKPARKVFKGASRVINKIPPSLLNDAELNEAIAALPANYNFEVHKTIWRVRETKAKRVALQMPEGLLMFSLVLSDIIERFTDADTVIMGDVTYGACCVDDFTAKALGADLLVHYGHSCLIPIDQTTGIKVLYVFVDIKIDTLHFVESVKLNFARDRPLAFVSTIQFVATLHAAAKELRETAGYDVLIPQSKPLSPGEILGCTAPRLSNGSGAETTTAPRTLIYLGDGRFHLEAAMIANPSLEAYKYDPYEKKFTRELYAHEAMRRNRKRAIDEARDAARFGLILGTLGRQGSTKVLEHLERRLKHHGREAVIILLSEIFPTKLARIENIDAFVQVACPRLSIDWGTAFPKPLLTPYELSVALGDAEWNIPECTAATEEKPRPVPNLEVTYPMDFYANASLGEWTPNFKKLDICENSTGGCCGRCKEEKDKEQKGKENATQLLLSVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL78</accession>
    <name>A0A182PL78_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Gem-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the core SMN complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the gemin-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PL78"/>
    <dbReference type="STRING" id="199890.A0A182PL78"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007695-RA">
        <property type="protein sequence ID" value="AEPI007695-PA"/>
        <property type="gene ID" value="AEPI007695"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007695"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017364">
        <property type="entry name" value="GEMIN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038038">
        <property type="entry name" value="SMN_Gemin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007695-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="280" mass="32051" checksum="E609FA306AC1CB10" modified="2016-09-07" version="1">MEVDTIQKPALAVEPPDANFDPNLTPETGEQYLQKVMYERGKCPVVVVAEKPQSRRQQKALSGLAAVPVDDVKNVAHRALIPTREWETMQNQKFSELRDIITSYRSGPQYQENLQRTHVFLNFDDRKHLHEYCANNLPYVSILLSIPQRNLEILLEYLHEWLQDADQTTSSASSQQLDEPSDPELCDTTVTPSTVNKELQRADGGYRRDWIPQWIYAILACIIKPLEPYIHSVLRDIAKTCITLRNELKMEDEAKVLPLNLLISIISNHFSQSDLSDNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLT9</accession>
    <name>A0A182PLT9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLT9"/>
    <dbReference type="STRING" id="199890.A0A182PLT9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007911-RA">
        <property type="protein sequence ID" value="AEPI007911-PA"/>
        <property type="gene ID" value="AEPI007911"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007911"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="2">
        <location>
            <begin position="55"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007911-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="232" mass="26244" checksum="435FA4941D40C437" modified="2016-09-07" version="1">MVDPNEDTEWNDILRAKGIIPPKPKEKEITEDEIIGMIESTIAEKQNGKDFSQLDLDELDELEDSEDEAVLQQYRQKRIAEMQAAASKARFGTVREISGQDYVEEVTKAGEGIYVVLHLYSRGVPFCALINQHLTQLAAAFPMTKFVRAIATTCIANYPERNVPTIFVYYEGQLKKQFIGAVELGGPNLTCDELEYMLGQAKAIETSIKEDPRESKKIKDKMFAELSDNNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLU8</accession>
    <name>A0A182PLU8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein alpha subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(i/o/t/z) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLU8"/>
    <dbReference type="STRING" id="199890.A0A182PLU8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007920-RA">
        <property type="protein sequence ID" value="AEPI007920-PA"/>
        <property type="gene ID" value="AEPI007920"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007920"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003559">
        <property type="entry name" value="Guanine nucleotide-binding protein G(i) subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF362">
        <property type="entry name" value="G PROTEIN ALPHA O SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007920-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17266" checksum="894B707AFCCD550D" modified="2016-09-07" version="1">MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTSEDFKQYRPVVYSNTIQSLVAILRAMPNLSIAFGNNERECDAKMVFDVVQRMHDTEPFSEDLLLAMKRLWSDSGVQECFCRSNEYQLNDSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMD3</accession>
    <name>A0A182PMD3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">UbiA prenyltransferase domain-containing protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMD3"/>
    <dbReference type="STRING" id="199890.A0A182PMD3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008106-RA">
        <property type="protein sequence ID" value="AEPI008106-PA"/>
        <property type="gene ID" value="AEPI008106"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008106"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042371">
        <property type="term" value="P:vitamin K biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000005">
        <property type="entry name" value="UbiA prenyltransferase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00751">
        <property type="entry name" value="menA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929:SF0">
        <property type="entry name" value="UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008106-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35169" checksum="3E8F083B9BEA78DD" modified="2016-09-07" version="1">MAAAATDRKAPPHIKAPLMKFKTYLSALRPWSLSGSLIPTLLGTALAYRVQDYERLSIFNFLCTVLTVVTVHCAGNVVNTYYDFVKGIDDRKADDRTLVDHILSQDEVVTLGVLLYGAGCLGFVCLVYLSPARLEHLALVFFGGLSSSFLYTGGFGLKYIALGDVLVLIIFGPISVLFSYMAQTGQYEWATIFYAIPLALNTEAILHSNNTRDAESDKRVGIVTLAILIGRTGSYILYAVLLFTPYVIFVVLGMKYSVLFLLPMVTFKQAFALERQFRNESTMQMVPRQTAKLNLFFGILYVVACFGAPQLPFITRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN21</accession>
    <name>A0A182PN21_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PN21"/>
    <dbReference type="STRING" id="199890.A0A182PN21"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008345-RA">
        <property type="protein sequence ID" value="AEPI008345-PA"/>
        <property type="gene ID" value="AEPI008345"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008345"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000948">
        <property type="entry name" value="Roundabout 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000026">
        <property type="entry name" value="roundabout homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="101"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008345-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="199" mass="21989" checksum="7AEC8C2498DF7BBF" modified="2016-09-07" version="1">QYRAPRIVEHPNNQIVPKNDPVTLNCKADGKPEPAIHWYKDGEPVKLTSNHVLLPSGSLFFLRTLHSKKENDAGVYRCVASNIAGIAESRNATLQIALLRDDFRVEPKDTRVAAGETALLECGAPKGSPEPSIRWMKDDVRLVLDEHLRSAKEIGRIRIVDGGNLLISDVRPSDGGRYQCVAYNVVGTRESSIARLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN91</accession>
    <name>A0A182PN91_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN91"/>
    <dbReference type="STRING" id="199890.A0A182PN91"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008416-RA">
        <property type="protein sequence ID" value="AEPI008416-PA"/>
        <property type="gene ID" value="AEPI008416"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008416"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF33">
        <property type="entry name" value="GLUTAMATE RECEPTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="294"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="368"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008416-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="674" mass="75941" checksum="120EEBFA86F96B8E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNE1</accession>
    <name>A0A182PNE1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182PNE1"/>
    <dbReference type="STRING" id="199890.A0A182PNE1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008468-RA">
        <property type="protein sequence ID" value="AEPI008468-PA"/>
        <property type="gene ID" value="AEPI008468"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008468"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008468-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="302" mass="33950" checksum="FAB5702E646D9761" modified="2016-09-07" version="1">MVQIDESKVSAIGDVLNNRDRPLKERFRALFTLRNIGGEQALDSIGRCFDDESALLKHELAYCLGQMQDVRAIPVLTKVLADVQQEPMVRHEAAEALGAIGDSSVEDTLVQYSKDPVVEVAETCEIALERVRWLKEKESLKDDNPYASVDPTPPAASKSVAELKRILMDESDKLFNRYRAMFALRNLRTEEATLALASGLKGKSALFRHEVAFVLGQLQEECSVPFLMENLRDPMENEMVRHECAEALGAIATDECTRVLNEYLKDEKRVVKESCEVALDMCEYENSPEFQYADTLVKVNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNV5</accession>
    <name>A0A182PNV5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E2F/DP family winged-helix DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNV5"/>
    <dbReference type="STRING" id="199890.A0A182PNV5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008634-RA">
        <property type="protein sequence ID" value="AEPI008634-PA"/>
        <property type="gene ID" value="AEPI008634"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008634"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000047">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="11">
        <location>
            <begin position="227"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="10">
        <location>
            <begin position="316"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008634-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52635" checksum="A1E495A9F8C6D4CE" modified="2016-09-07" version="1">MKTIVAKDLKISNLANQGKAAMSVTADNLDIVGTAMKSSAPGVVAGQYKVISTTSSPHSVSRNLTFSPPANSSLQNNVVTVPSNNIAFTKTLGITSSNAIASTSVITKPPSLTVASNAFSSTARCNGDSKSPSVTNKPLNTISEAVSLENGSINNGTIGKSSSENGNDCPSFLQMSSASTISSAVNTFQQSNQSNKMHSQQQQHSYSKKTSPSQMHIPASRRQKADKAGRGLRHFSMKVCEKVKAKGTTTYNEVANELVAEETQNHHPGVDPGTYDQKNIRRRVYDALNVLMAMKIISKEKKEIRWHGLPTSNTLQECEELEKENEKARRRIEIKQQQLLDLIQQHVALKSLITRNKANEERGLVPNPNSAVQLPFIIVNTDRKSNINCNISNDKSEYSFKFEDSFEIHDDVQILKRIGLSLAYGLGFEQDDVDDWEMSSLYNGPDNDDSLSTQDMLAFNDTTNDMLDDDMKFEDDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP39</accession>
    <name>A0A182PP39_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP39"/>
    <dbReference type="STRING" id="199890.A0A182PP39"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008718-RA">
        <property type="protein sequence ID" value="AEPI008718-PA"/>
        <property type="gene ID" value="AEPI008718"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008718"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000035">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF505">
        <property type="entry name" value="TRANSMEMBRANE 4 SUPERFAMILY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008718-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="271" mass="30560" checksum="A7413766E5EC473E" modified="2016-09-07" version="1">MYLYPHFIQICGGAQLVIGAFLLWTHKQYAPIVKNQFWEPFAVLIALGVISQGLCYLGWTSTSRKQRCYLGLFCAFLVLFIVILFLVSGWSIATKAHLIVPAELAIESSFSEFLAKDNTNDQTHIWNRLQRDFRCCGYNGIHDYKKNKQMGFPWSCYDPIDTKVFNTGCMHVFVKSIEMNMIRVAVVAVASALIQSLGIFCAIQLTMLLRRPTLMLPNGDNHSVRVKRTREMTPLATATIGNPTPHSSTKPPIPLKPVVPRIDQPVMKSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP88</accession>
    <name>A0A182PP88_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDGSH iron-sulfur domain-containing protein 2 homologue</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="10">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CISD protein family. CISD2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP88"/>
    <dbReference type="STRING" id="199890.A0A182PP88"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008767-RA">
        <property type="protein sequence ID" value="AEPI008767-PA"/>
        <property type="gene ID" value="AEPI008767"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008767"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045131">
        <property type="entry name" value="CISD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019610">
        <property type="entry name" value="FeS-contain_mitoNEET_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13680">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13680:SF5">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10660">
        <property type="entry name" value="MitoNEET_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="11">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008767-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="132" mass="14628" checksum="1D0CC102F584B255" modified="2016-09-07" version="1">MQLLSGLVKTTVPNYLSGLPIPDTFGGWFRLGFKDWLSLVPPTAAVAGVVYMSYLAFCPEARPKPSQKANNKIRLDEAKVVDMIDIEDIAEKAAFCRCWKSNNWPYCDGSHGAHNKECGDNLGPVVVQRKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ27</accession>
    <name>A0A182PQ27_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQ27"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009057-RA">
        <property type="protein sequence ID" value="AEPI009057-PA"/>
        <property type="gene ID" value="AEPI009057"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009057"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009057-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="130" mass="14830" checksum="59CA78BFC09918C6" modified="2016-09-07" version="1">MVRMQIDMMSMAVRFKVMATEIMSAKVVLEQATLIVALLALHCWFRFLGRRLLLLLLGRRTQDHVLQSAASMAYDKRCHHVAMSVTERWCDDSSPTHLTHVSVPQRINCSVKTGKLMKNETNLNKPHIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQU1</accession>
    <name>A0A182PQU1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cathepsin propeptide inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQU1"/>
    <dbReference type="STRING" id="199890.A0A182PQU1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009322-RA">
        <property type="protein sequence ID" value="AEPI009322-PA"/>
        <property type="gene ID" value="AEPI009322"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009322"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018556658" description="Cathepsin propeptide inhibitor domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="117"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="207"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009322-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36929" checksum="04D29CAB88B1B3C6" modified="2016-09-07" version="1">MHIRGSHFVLCLTVVGFAAGVNFPPSQRQGKAPARAVLKPARNRHPPQTAILQSVGMRSHGEESSGVVSLSQELDMVEPIVGAPDNTEQQPPATTASAVPENSTLPAVATTTEADMFNSYMNTHRKRYYAKYRADRRRSALLENMEEIKEHNKAFEAGSNRFRMAPNAFADMQNSEYRKRLVRLKMDPHRKVEPAMADEIVSSSNELPDEIDWRKKGFVTEAANQKTCGSCYAFSVAYAISAQLMKHIGRVELVSEQQMVDCSTANGNLGCGGGSLRNTLKYLEQAGGVMRDVDYPYTSSVSRQMDGYCPRVCVGARRESGSPLYLKSEDIPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR95</accession>
    <name>A0A182PR95_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Membrane</location>
            <topology evidence="2 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PR95"/>
    <dbReference type="STRING" id="199890.A0A182PR95"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009477-RA">
        <property type="protein sequence ID" value="AEPI009477-PA"/>
        <property type="gene ID" value="AEPI009477"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009477"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008020">
        <property type="term" value="F:G protein-coupled photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001391">
        <property type="entry name" value="Opsin_lateye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00578">
        <property type="entry name" value="OPSINLTRLEYE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 16" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4 16" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="14 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="640"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="857"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="895"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="936"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="985"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1047"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="65"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="430"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="837"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1121"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1128"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009477-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1144" mass="128494" checksum="19F18FEBF1156896" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS34</accession>
    <name>A0A182PS34_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4704 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PS34"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009769-RA">
        <property type="protein sequence ID" value="AEPI009769-PA"/>
        <property type="gene ID" value="AEPI009769"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009769"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF4704" evidence="3">
        <location>
            <begin position="831"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1383"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1387"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009769-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1704" mass="191390" checksum="954505B453BA2AC3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS57</accession>
    <name>A0A182PS57_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein osiris 22</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PS57"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009792-RA">
        <property type="protein sequence ID" value="AEPI009792-PA"/>
        <property type="gene ID" value="AEPI009792"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009792"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131766" description="Protein osiris 22" evidence="3">
        <location>
            <begin position="27"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009792-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="54220" checksum="46C9457A3FADC632" modified="2016-09-07" version="1">MATFYRTVQLGALVLCAVFCLACATAETTTGNEADSSFDADIMEGRTFGHHFLKRISFAMIPAAFVVGVITTLLSALTVVSMKGLGVGDSSRAYHLASHCQKLPDPATTASSGRLQCTRTRTDTARLQGLVNSSFPSQTLSSTCGPYLTRGEMRKSWQAKSVDIQAQMLKAARLEDPPNAKPPEERELEVTRSVAATEVSTTGQTGGPGSSSTGSVKAVVEELKAKPAPVFSSRVRSKYGTVGGSSVVPDKVTEAAVVTTHREDEERRAVPPVMEHNPEDIQIDDATVQDDDDDEDDEDDDDDDRLGWNAAAQGDKAQQYDLIENILEEVEGRIAGQGKRDEVEEELSSSKEKKPTQRIKEYTFPPVLNMTIDEPNNIVKVKLNQDIVRDMLNTGRESGGGIGGKKMLRYVLPLFILPFLIQSAVIPFMLTAVKLFLLKSLMAGKLAIFLLLLGAFKNFTKKDGRDVYVKDLPDRRYEPSSEGFAYLAEGRPSGWVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSH3</accession>
    <name>A0A182PSH3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Strictosidine synthase conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSH3"/>
    <dbReference type="STRING" id="199890.A0A182PSH3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009908-RA">
        <property type="protein sequence ID" value="AEPI009908-PA"/>
        <property type="gene ID" value="AEPI009908"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009908"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000065">
        <property type="entry name" value="Hemomucin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131707" description="Strictosidine synthase conserved region domain-containing protein" evidence="5">
        <location>
            <begin position="31"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="6">
        <location>
            <begin position="180"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009908-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="447" mass="48306" checksum="77376E6BF9B9681E" modified="2016-09-07" version="1">MGLKGKLFKASLVLMLIAFLPGLPPKTVFPFKPIAISKERPLTGVLAPNQLLNGAERLHEGGLLQPEGVVVRGNVTYVTVYGGKILELGEQGSVRTVAKLGPECVGTYSERICGRPLGIDFDTKGNNLIVADPYLGIWQVHIKTGEKKLLVSKDNAIIVDDQAESEAVRKVRTRQPNIPNGVAVARNGDFYWSDTASDFIFEDAIQAVLCNPSGRLLHYSRAEGKSRVLIDEVYGANGVVLSPDESFVLVGELGGQLIRRYYLKGPKAGTHDVFIDGLPGAVDNLNGDDNGFWVGLVIAADESNPSFVSMLAPFPNLRRLLVRLFVLVEAPFRLWHGATGSDFALWATHHIGHLGGLVALFPDRGTVLRLDWEGNIVLALHNDDTSSHVISQAVPFGADQLLLGSPVNQWLGRVKLTPETLATLKGGSKGQPSKQQPTGAPPSREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSQ4</accession>
    <name>A0A182PSQ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="16">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="16"/>
    <dbReference type="STRING" id="199890.A0A182PSQ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009990-RA">
        <property type="protein sequence ID" value="AEPI009990-PA"/>
        <property type="gene ID" value="AEPI009990"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009990"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000019">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 16" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 16" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="18">
        <location>
            <begin position="1546"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1212"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1231"/>
            <end position="1241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009990-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2223" mass="254033" checksum="8B26CDEE85E35513" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSX9</accession>
    <name>A0A182PSX9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSX9"/>
    <dbReference type="STRING" id="199890.A0A182PSX9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010065-RA">
        <property type="protein sequence ID" value="AEPI010065-PA"/>
        <property type="gene ID" value="AEPI010065"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010065"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03403">
        <property type="entry name" value="SPFH_stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF127">
        <property type="entry name" value="PODOCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="41"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010065-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="279" mass="30937" checksum="C6C7270A54E4B036" modified="2016-09-07" version="1">TLFLHIPAEDDTNGEASTCGRILIFLSWVLVVLTMPFSLLVCFKVVQEYERAVIFRLGRLMQGGAKGPGIFFILPCIDAYARVDLRTRTYDVPPQEVLTKDSVTVSVDAVVYYRVSNATVSIANVENAHHSTRLLAQTTLRNTMGTRHLHEILSERMTISGSMQLSLDEATEAWGIKVERVEIKDVRLPVQLQRAMAAEAEAAREARAKVIAAEGEQKASRALREASEVIGDSPAALQLRYLQTLNTISAEKNSTIVFPLPIDILTYFMKSKEAFVPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTC5</accession>
    <name>A0A182PTC5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PTC5"/>
    <dbReference type="STRING" id="199890.A0A182PTC5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010211-RA">
        <property type="protein sequence ID" value="AEPI010211-PA"/>
        <property type="gene ID" value="AEPI010211"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010211"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052435">
        <property type="entry name" value="YY1-Transcr_Regul"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16088:SF3">
        <property type="entry name" value="GON-4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16088">
        <property type="entry name" value="YY1 ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010211-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="634" mass="71976" checksum="BFCDA5CFB07B71FF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTD8</accession>
    <name>A0A182PTD8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTD8"/>
    <dbReference type="STRING" id="199890.A0A182PTD8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010224-RA">
        <property type="protein sequence ID" value="AEPI010224-PA"/>
        <property type="gene ID" value="AEPI010224"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010224"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000005">
        <property type="entry name" value="39S ribosomal protein L13, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010224-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="178" mass="21111" checksum="70B8262823CD6552" modified="2016-09-07" version="1">MSVTQRVQQWATFARTWHIFDCTWQNPFEAASLIRKHLMGLHKPIYHPMNDCGDHVVVINTAEIALPGDEWKKRAYFHHTGYAGGASWTLAWQLHEKDPTMIMKKAIYRAMKGNLQRRHTMQRLHLFKDGEVPKDILENVTNQIRQPRRVPQRLDHIDPEMVRNFPKVMDYPKDYILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTP3</accession>
    <name>A0A182PTP3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PTP3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010329-RA">
        <property type="protein sequence ID" value="AEPI010329-PA"/>
        <property type="gene ID" value="AEPI010329"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010329"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000246">
        <property type="entry name" value="Cadherin 86C, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000295">
        <property type="entry name" value="Cadherin 86C, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000098">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000259">
        <property type="entry name" value="cadherin-86C isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131945" description="Cadherin domain-containing protein" evidence="15">
        <location>
            <begin position="46"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="859"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="173"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="275"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="392"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="509"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="635"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="686"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="936"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1059"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1340"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1436"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1598"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1834"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1280"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="942"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="981"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1059"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1386"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1498"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1525"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1604"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1614"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1638"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1685"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1704"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1725"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1853"/>
            <end position="1872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010329-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1930" mass="212423" checksum="FFE1A38E5C05C95A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU19</accession>
    <name>A0A182PU19_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms a heterodimer with PSMG1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the PSMG2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU19"/>
    <dbReference type="STRING" id="199890.A0A182PU19"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010455-RA">
        <property type="protein sequence ID" value="AEPI010455-PA"/>
        <property type="gene ID" value="AEPI010455"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010455"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010455-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="243" mass="27213" checksum="A4E69AE50CB99DDD" modified="2016-09-07" version="1">MFSFKQEIDFTGYSFIVPSVSVGNVPQLAVDAVIETLQLEPIGLLWSPALVPIVGAPAFEHTVTNDATMTTTAELYISQEKKLLVLQIRAPLVAPLRQSFLGELSDFVRDRKFSHVILLASCFSHEKFDIRTGPFRYVANELYEQTAHGEHLKDDRWTKHTGGVIHGGGYASKLLEALTDRKVPAVVFFMYVSEGDNTAEGLMLARMLNAISGERLLASERTDFRWPSSWKHLFGTAHPRTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUL5</accession>
    <name>A0A182PUL5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DOMON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUL5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010652-RA">
        <property type="protein sequence ID" value="AEPI010652-PA"/>
        <property type="gene ID" value="AEPI010652"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010652"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF40">
        <property type="entry name" value="MOXD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOMON" evidence="1">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010652-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="67" mass="7761" checksum="BAD5EDE0F1656DEF" modified="2016-09-07" version="1">MQMRLDRHVKKHGDGEPLVDSSQDYVLLLGYENQTHTVLRFKRKLDTCDVAYDVPITVSEARTNRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVC5</accession>
    <name>A0A182PVC5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVC5"/>
    <dbReference type="STRING" id="199890.A0A182PVC5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010912-RA">
        <property type="protein sequence ID" value="AEPI010912-PA"/>
        <property type="gene ID" value="AEPI010912"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010912"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002299">
        <property type="entry name" value="Krueppel factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002692">
        <property type="entry name" value="Kruppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010912-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="291" mass="32827" checksum="1FE4C1F394FEF08F" modified="2016-09-07" version="1">MIDTDRIAEMMELGSFEQSSDDFLANGFYHLYTELQDDRDIALALAELTCPTSQGTGQGPDEVRTAPATADLPSLEHTLQGEVDGLELEVNVEDFILEYNCVNFSQLWENELKLPESTYLCDDSCEAFIRQSSTTKEDTVQPEVPRTCPATVPSSAHRPSETEPDSTGTFVCPFESCRKVYAKPVHLKAHLRRHVGDKPYRCKWPGCQWRFSRSDELSRHFRSHSGVKPYRCEYCPKCFSRSDHLAKHRKVHERKMSAGAGKLKPDGTFVGVTPARGRPGRKPKQTAVKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVT9</accession>
    <name>A0A182PVT9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein ABHD13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Alpha/beta hydrolase domain-containing protein 13</fullName>
        </alternativeName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVT9"/>
    <dbReference type="STRING" id="199890.A0A182PVT9"/>
    <dbReference type="ESTHER" id="anoga-q7q887">
        <property type="family name" value="ABHD13-BEM46"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="AEPI011076-RA">
        <property type="protein sequence ID" value="AEPI011076-PA"/>
        <property type="gene ID" value="AEPI011076"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011076"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="114"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00042701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011076-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="306" mass="33981" checksum="DDDEE363D32F08B7" modified="2016-09-07" version="1">MSFRDWKIVRVLAGIAMRIWAASGAALLSAFLIYVVYGGFFAFLLLLFAVSGILYHAQDNLLYHPELPANSRIFIPVPSMHGLPYETLHLKTRDAVSLHAFWIRHPGDKGRYVPTIVYFHGNAGNMGHRLQNASGFYHTLQCNVLMVEYRGYGLSTGTPSEKGFFADARSVLDHLFSRHDLDHGQIVVFGRSLGGAVSIDLAADAVYGSRIMGVIVENTFTSIPDMAVELIHPAVRYLPLLLYRNQYLSVDKIQFISAPILFVSGLADTLVPPRMMTMLHTRCGSTRKQMLQIVGGSHNDTWAVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW16</accession>
    <name>A0A182PW16_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PW16"/>
    <dbReference type="STRING" id="199890.A0A182PW16"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011153-RA">
        <property type="protein sequence ID" value="AEPI011153-PA"/>
        <property type="gene ID" value="AEPI011153"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011153"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF31">
        <property type="entry name" value="SIDESTEP II, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="107"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011153-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="401" mass="44061" checksum="496D3BDC698E3157" modified="2016-09-07" version="1">MVQFCSSDPPIVSLRLGSTLSADDIKEGDDVYFECHVQANPPWRKLHWLHDGVMITHNASARVIRSNQSLVLQKVTRNSSGNYSCSAINAEGETVSNQLALRVKYAPVCATDRIIIVGAFRSESLQIPCEVHADPPPRQFNWKFNNSGETLKIGKERYVKNGSLSLLNYVPVSDQDYGTLTCWGQNEVGTQDWPCFFQVVLAGLPAAVKNCSINNQTQHSVEVQCLPGYDGGLPQIFILEVISSRTGRVRYNVTNPDEPYFLVESLENLIHYGGAYDDIGDDNPLKAVIYAVNQKGRSQGIVVKDFYLESSVENRAGVLTSNSLDSISPILFGVLLTLLVLCFVIFVRVYYIKATATSTTITTSNDLVSNSKQGNNKQDTLAKVSASNGSRAQGYITFALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWK6</accession>
    <name>A0A182PWK6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWK6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011343-RA">
        <property type="protein sequence ID" value="AEPI011343-PA"/>
        <property type="gene ID" value="AEPI011343"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011343"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011343-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="40" mass="4496" checksum="7B3CA3ABC783F39B" modified="2016-09-07" version="1">MALVPLSRKRCVLKNMVSGYQPDTINTGFKVAFDSLKFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWL5</accession>
    <name>A0A182PWL5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWL5"/>
    <dbReference type="STRING" id="199890.A0A182PWL5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011352-RA">
        <property type="protein sequence ID" value="AEPI011352-PA"/>
        <property type="gene ID" value="AEPI011352"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011352"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5641" evidence="2">
        <location>
            <begin position="192"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011352-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34623" checksum="E610989F3745FFBB" modified="2016-09-07" version="1">MMDQHGILRMEGRTANAEILPFDLRFPMILPNNHPITLLIVKSYHERCGHGYRQAVKNELRQLYYIPHVDAVVRKVASSCVWCKVKRNHPETKWTFNPPAAPHMGGVWERLVRSLKAAMTALDDGRRLTDEILLTVIVEAEDVVNSRPLTTVTQEDGVEVTLTPNLFLRGYSSSDSRSQPTTDTKGALKDHYLRTQQLTNEFWIRWIKEYVPGINLRTKWHGETRQLRTGDLVYIVDGDNRQNWRNLSCPGTGEFDKLGSAPTTADIGERRENLWFWNWNRSNASQRLRAGLRAGECWGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX25</accession>
    <name>A0A182PX25_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PX25"/>
    <dbReference type="STRING" id="199890.A0A182PX25"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011512-RA">
        <property type="protein sequence ID" value="AEPI011512-PA"/>
        <property type="gene ID" value="AEPI011512"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011512"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007021">
        <property type="entry name" value="DUF659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04937">
        <property type="entry name" value="DUF659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011512-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="222" mass="24758" checksum="55BB68622627777E" modified="2016-09-07" version="1">MAPTNSTTSPIWDHFTQAENGAKCRYCLKVFSFSKGTTSNLKRHLNLVHKTVPYARRQPTTSTAINIDDEAEPSGLNHLQSNQRANENVVIQKLEKVKDKLTTTKAIALTSDGWTNINNTSFMALTGHYIDENFKFQSTLLDCSEFEKIHSGLNIANWIADTINQFGITNKVVAMITDNASNMKAAVKELKLDHIPCFAHTLNLIVQHAVNNSVSVIEEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX51</accession>
    <name>A0A182PX51_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX51"/>
    <dbReference type="STRING" id="199890.A0A182PX51"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011538-RA">
        <property type="protein sequence ID" value="AEPI011538-PA"/>
        <property type="gene ID" value="AEPI011538"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011538"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011538-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32488" checksum="B21F1AFAA98E4257" modified="2016-09-07" version="1">MDDVLSGAESIEEAITALQQLRNLLNRGGFPICKWCSNSPEFLSTIPEQERELSMQLHERNINSIIKVLGLLWDPNTDLLYIAHQISPLTGACVTKRHIYSQIAKNFDPTGLVAPVLVLAKLFAQRMWQLKMNWDDPIDSTLRHEWCELENNLTELQSISIPRCVTNQAATEYEIHGFADASNMAYGACIYIRCLLTDGSAKMNLLTSKSKLAPLRDLSIPRKELCAALLLARLMDRVVPAINISAKEVILTTCGAVASWYLKFDQRVEATILAVKCEVDREEDYLSMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX57</accession>
    <name>A0A182PX57_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX57"/>
    <dbReference type="STRING" id="199890.A0A182PX57"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011544-RA">
        <property type="protein sequence ID" value="AEPI011544-PA"/>
        <property type="gene ID" value="AEPI011544"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011544"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="211"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011544-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="803" mass="91902" checksum="848C3DBCE127E7C9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX66</accession>
    <name>A0A182PX66_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX66"/>
    <dbReference type="STRING" id="199890.A0A182PX66"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011553-RA">
        <property type="protein sequence ID" value="AEPI011553-PA"/>
        <property type="gene ID" value="AEPI011553"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011553"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011553-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="144" mass="15408" checksum="7A657C37DBA58FF5" modified="2016-09-07" version="1">MAELSISSVAPLASGEEMAKALSALVNETVPEAEVRMREAWNGTQTARVRVTERAAELAAGKSLKILYTSCQVSIVQLSTTGPQRCFRCLQFGHLRAKCPSEVDRSEACIRCGVTGHLSRSCTAPVSCAVCKGPHRMGSPECKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PXA2</accession>
    <name>A0A182PXA2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-C2HC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PXA2"/>
    <dbReference type="STRING" id="199890.A0A182PXA2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011589-RA">
        <property type="protein sequence ID" value="AEPI011589-PA"/>
        <property type="gene ID" value="AEPI011589"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011589"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011589-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35464" checksum="79A9AA470B6CE882" modified="2016-09-07" version="1">MVKKKKTEEISPGALGDERKCDSMQIKINEMDVEEGEFIRVERGTKRAAPTPSPVPDVTVPDATVPEATVPGVTVPKPSQRFPPIVVKNPRFQELRTALQHVANVEYQIVGVGTKVFVKREEDFAAVLTFLETSNCEFYTHDLPKNRPFKVVIRGLPLMEECDIQQCLEQEGVQVTGIYRIKRRHEGDGDNGNCLYLIHIKKGTTRLSELKEIRALLSIRIRWEAFRGGRRGVTQCLRCLGFGHGSRNCAMRKRCMNCGQEHGVAECTADATDEPKCANCGGKHRANDKECSNRARFEQIRQQASNRQRRQTAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PN96</accession>
    <name>A0A240PN96_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Yellow protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PN96"/>
    <dbReference type="STRING" id="199890.A0A240PN96"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015248-RA">
        <property type="protein sequence ID" value="AEPI015248-PA"/>
        <property type="gene ID" value="AEPI015248"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015248"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF10">
        <property type="entry name" value="L-DOPACHROME TAUTOMERASE YELLOW-F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012783099" description="Yellow protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015248-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48866" checksum="7474320BF3D151B7" modified="2017-10-25" version="1">MNYWHRCTTHILCAIFVLGAGGTEFEKVFEWKQMSYLDLPDLSKDNGTILFPRALGATENETFQAYNNIPMGATHHKNRLFITIPRRRPGVPATLNVIDLTKVPRGERSPPLTAYPNYRINELQPLYEPDLRRLISVYRTSVDACERLWFVDTGMLEYPNNRVQVQRPQLWIIDLQRDQLVRRYTIPASIVREGVGMASVTVDVEPTDCDGAFAYIPDLTANAIHVYSLRDNDMWSFNHSSFAHDPSRAAFSVAGQRFEWDDGVFSLALGQNDTVAGSKLVYYHPMVSTTEFGTFTNVLQSKRIALSGYYDGLFEMLGERGANTQSTMHHYDPRTGVLFYAEVNRNSIGCWNTRQLFAADNHAVVHLDNRELIYPTDLTSDSEGVLWVLTNNLPVWIYSRLNESDYNYRLWRQDPAVAIRGTKCDNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9GVP4</accession>
    <name>A0A2C9GVP4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2C9GVP4"/>
    <dbReference type="STRING" id="199890.A0A2C9GVP4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015423-RA">
        <property type="protein sequence ID" value="AEPI015423-PA"/>
        <property type="gene ID" value="AEPI015423"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015423"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015423-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="413" mass="45917" checksum="229995D0BE3D1B86" modified="2017-12-20" version="1">MKLNVSFPATGAQKTFEIPSDDHKLRHFYDKRMGTEITADHLGEEWKGYILKIAGGNDKQGFPMKQGVLTNTRVRLLLKKGHSCYRPRRAGERKRKSVRGCIVDQNLSALALIIVRKGEKDIPGLTDVNVPRRLGPKRASNIRKLFNLQKEDDVRQHVIKRPLPVKDGKKPRFKSPKIQRLITPVVLQRKRHRLLIKKRRSEARREAEAQYVRLLALRRRQERVRRHSRLSSIRDSRSSLTSEKDKKSLAAAKKKEAATKKEASATKKEVAPAKKGAVAKKEVAKKDAGKKAAATKKEVKKDAGKKEVKKDTAKKEVKKDGKKEEKKPAAASAGKKAAASSAKPEAAKKAAPKTEGKKPVAGAAEKKPAAKKETAAPAAKKEAPKRKPEPAAQQKGEASAAKKEKKQQQPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FGV5</accession>
    <name>A0A9I3FGV5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nebulin repeat protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A9I3FGV5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015487-RA">
        <property type="protein sequence ID" value="AEPI015487-PA"/>
        <property type="gene ID" value="AEPI015487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09447">
        <property type="entry name" value="LIM_LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11789">
        <property type="entry name" value="SH3_Nebulin_family_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000087">
        <property type="entry name" value="LIM zinc-binding domain-containing Nebulette"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051759">
        <property type="entry name" value="LIM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000900">
        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218">
        <property type="entry name" value="LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218:SF4">
        <property type="entry name" value="LIM AND SH3 DOMAIN PROTEIN LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00880">
        <property type="entry name" value="Nebulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00227">
        <property type="entry name" value="NEBU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="576"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015487-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="70469" checksum="37E6EC56746E9CA2" modified="2023-06-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZJ2</accession>
    <name>A0A182NZJ2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZJ2"/>
    <dbReference type="STRING" id="199890.A0A182NZJ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000073-RA">
        <property type="protein sequence ID" value="AEPI000073-PA"/>
        <property type="gene ID" value="AEPI000073"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000073"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000073-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="186" mass="19740" checksum="F05DCED23F91893C" modified="2016-09-07" version="1">MDNPSYGSAHMSSPALVVFSQATNGLSDALRIQRPFHSQLPDAKDLHHLSLMSGYGAHLLHGFQPHFLHPLNPAVSTASGTSPFSGGGAFVKPFPSNLPLPSAFAPPKCLGFGIDQNIFSKGLLFGSSGSGSESFRTDSSSPACTSLSPPAKDESLEGQTSEDGDRERDRICTPERSPETPGFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0K6</accession>
    <name>A0A182P0K6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an olfactory role that is not restricted to pheromone sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0K6"/>
    <dbReference type="STRING" id="199890.A0A182P0K6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000438-RA">
        <property type="protein sequence ID" value="AEPI000438-PA"/>
        <property type="gene ID" value="AEPI000438"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000438"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF89">
        <property type="entry name" value="GH15894P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000438-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="126" mass="14796" checksum="0128CB395B8EC38C" modified="2016-09-07" version="1">MKPDRESQHSYAIVDPSFGIPLDQCARTQTNLAIPKLTGYSPEIRRFSEMIIPMFWIEYHQQELPSYIVRTLQAFYVVRDVEPYLPYVLYLCFMLLLAIAFREAARYKMHGKISPTKYTKPQLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0L2</accession>
    <name>A0A182P0L2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CARMIL C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CARMIL family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P0L2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000444-RA">
        <property type="protein sequence ID" value="AEPI000444-PA"/>
        <property type="gene ID" value="AEPI000444"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000444"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000009">
        <property type="entry name" value="F-actin-uncapping protein LRRC16A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031943">
        <property type="entry name" value="CARMIL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041245">
        <property type="entry name" value="CARMIL_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF66">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17888">
        <property type="entry name" value="Carm_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16000">
        <property type="entry name" value="CARMIL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CARMIL pleckstrin homology" evidence="11">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CARMIL C-terminal" evidence="10">
        <location>
            <begin position="790"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="960"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1108"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1276"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="972"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1159"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1286"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1302"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1321"/>
            <end position="1343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000444-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1401" mass="153193" checksum="72F1F2D01A786518" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0P0</accession>
    <name>A0A182P0P0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P0P0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000472-RA">
        <property type="protein sequence ID" value="AEPI000472-PA"/>
        <property type="gene ID" value="AEPI000472"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000472"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001864">
        <property type="entry name" value="zinc finger protein 883-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1176"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1269"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1362"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1401"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="518"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1122"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1284"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1325"/>
            <end position="1342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000472-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1695" mass="187913" checksum="21D0AC14F35AE767" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0T1</accession>
    <name>A0A182P0T1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0T1"/>
    <dbReference type="STRING" id="199890.A0A182P0T1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000513-RA">
        <property type="protein sequence ID" value="AEPI000513-PA"/>
        <property type="gene ID" value="AEPI000513"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000513"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000513-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="256" mass="29175" checksum="6774CEEF8D3F557E" modified="2016-09-07" version="1">MLQVLKRLDEIDQRISHLERRIQSNQHVATALITDKLEGISVGTYYGSCQEAPALLSDVYTIKPPASSVAPFRVYCEQSYRQGGWIVLSRRFDGSLNFTRDWVDYRDGFGTPEGEYWLGLEKMHRITGSDYFQLLVHLKDYDGTVKTALYDEFEIGSESTGYRLHLGSFVEGSAKDSLRVSAGMKFSTPDRDNDEHPGSCAAYYASGWWYRNCMNANLNGLYKRFDANNATMNWFNFRGDLQGLKEATMMIREVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1F8</accession>
    <name>A0A182P1F8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP synthase subunit beta</fullName>
            <ecNumber evidence="17">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 17">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A182P1F8"/>
    <dbReference type="STRING" id="199890.A0A182P1F8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000740-RA">
        <property type="protein sequence ID" value="AEPI000740-PA"/>
        <property type="gene ID" value="AEPI000740"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000740"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000006">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 17" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 17" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="170"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="525"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000740-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="855" mass="91958" checksum="86C421E11CAEB185" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P240</accession>
    <name>A0A182P240_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P240"/>
    <dbReference type="STRING" id="199890.A0A182P240"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000974-RA">
        <property type="protein sequence ID" value="AEPI000974-PA"/>
        <property type="gene ID" value="AEPI000974"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000974"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF50">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130717" description="Peptidase S1 domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="53"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000974-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="299" mass="32559" checksum="012F2669E841705D" modified="2016-09-07" version="1">MKQIALLFVTVLSVQGVDWTRVQPVEELDHYWARLPAELQIYRNDTFRPAARITNGLEARSGQFPYQALLLTEFGMLTIMCGGSVLTQNFILTAAHCVMLDQTTKATGGMVILGAHNRLEVEPTQQRIRFGTGGVMVHPWYAASNHRYDVAVVRLNTPLRYTSYVQPVRLPGRNDQRQFDGLIGTVSGFGRTSDVGGSFASILQYTVNTIMSNSACIGVWGSVLIEPHNMCLTGDGGRAACTGDSGGPLTINESGQTIQVGVTSFGSANGCTSGMPTVYGRITYFLDWIRANSDYVTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P261</accession>
    <name>A0A182P261_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P261"/>
    <dbReference type="STRING" id="199890.A0A182P261"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000995-RA">
        <property type="protein sequence ID" value="AEPI000995-PA"/>
        <property type="gene ID" value="AEPI000995"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000995"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000995-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="193" mass="22474" checksum="66B24C2BBA146F36" modified="2016-09-07" version="1">MVVVVRMFIIVVTIFAICWLPYHLFFVYAYHNNQMTSSSYVQQLYLGFYWLAMSNAMVNPIIYYWMNGRFRVYFQEIICFCCLQFINSRMRDGVPQGVLLNKNSNSELGRYRSYRPRSVSVRWRPPSTEEYRMRTGLPRPAHLGVNVLEGAANGASDKQPVADIAELQTINFLHLNHNSNELQHSSSNSHEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P265</accession>
    <name>A0A182P265_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P265"/>
    <dbReference type="STRING" id="199890.A0A182P265"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000999-RA">
        <property type="protein sequence ID" value="AEPI000999-PA"/>
        <property type="gene ID" value="AEPI000999"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000999"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000999-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="149" mass="16606" checksum="0F5DCFB06D39ED5D" modified="2016-09-07" version="1">MSESVELELLINCTQATVVRFPWSADLNTTVIGDLNRTEVLDVLAEMITRSRGYVPKSADPLTLREFITECLFPTTKSPYELPWQLKTAWGVVFGAMLLVAITGNCIVLWIVLGKWIRSGDATDGRGVDPGSINLRVSRVQILERMHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2F8</accession>
    <name>A0A182P2F8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sidestep protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2F8"/>
    <dbReference type="STRING" id="199890.A0A182P2F8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001092-RA">
        <property type="protein sequence ID" value="AEPI001092-PA"/>
        <property type="gene ID" value="AEPI001092"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001092"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF28">
        <property type="entry name" value="SIDESTEP IV, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="125"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="227"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="326"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="423"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="523"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="650"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001092-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="95584" checksum="3E1B7F7A91CC7823" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2Z6</accession>
    <name>A0A182P2Z6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2Z6"/>
    <dbReference type="STRING" id="199890.A0A182P2Z6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001284-RA">
        <property type="protein sequence ID" value="AEPI001284-PA"/>
        <property type="gene ID" value="AEPI001284"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001284"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000018">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001284-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29724" checksum="26969C916D0F1DB6" modified="2016-09-07" version="1">MDLQSNDREKGEKVKIVNQIKHIPKDAQVVMSILKELGATDYEPRVINQLLEFTYRYVTCILDDAKIYANHARKKVIELDDVKLATQMILDKAFTRPPPRDVLLEIARVRNATPLPLIKTHCGLRLPPDRYCLSSCNYKLRAAQQSKRMNKSALEGRSSLKAAKAAAAAAAAGGDGTSSGGGVKRPSVQSTPKTQVVSIPKPVFKFSTAPKTTPSAATKPVKTTVTSIGSNGASTGNAGAPGAVDIKMETDDQFGETTNGNKRKREEDDFEIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P336</accession>
    <name>A0A182P336_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P336"/>
    <dbReference type="STRING" id="199890.A0A182P336"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001320-RA">
        <property type="protein sequence ID" value="AEPI001320-PA"/>
        <property type="gene ID" value="AEPI001320"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001320"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21739">
        <property type="entry name" value="NES2-NLS_ChREBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF37">
        <property type="entry name" value="LD38259P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001320-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="99" mass="12011" checksum="7006CB44B3ECC443" modified="2016-09-07" version="1">QKLTSPKWNPFKGIRLRWKEKIRLNNVIWRCWHMQFIMKRKTLVCQFASPLDVDVHNTPQAILLEGKYWKRKCNVIKAEYKKWRRFNVNRALGATNIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P423</accession>
    <name>A0A182P423_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="STRING" id="199890.A0A182P423"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001659-RA">
        <property type="protein sequence ID" value="AEPI001659-PA"/>
        <property type="gene ID" value="AEPI001659"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001659"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000022">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056850">
        <property type="entry name" value="ARM_UBP34_24_USP9X_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF943">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE PUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25010">
        <property type="entry name" value="ARM_UBP24_USP9X-Y"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="2218"/>
            <end position="2677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="738"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1446"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1667"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2452"/>
            <end position="2578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2683"/>
            <end position="2747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2752"/>
            <end position="2771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2782"/>
            <end position="2869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="4248"/>
            <end position="4360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="4390"/>
            <end position="4547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1676"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1719"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2467"/>
            <end position="2486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2492"/>
            <end position="2508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2509"/>
            <end position="2519"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001659-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="4547" mass="503067" checksum="49556B9C602FF12D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P463</accession>
    <name>A0A182P463_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P463"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TR-Histone_Methyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16516">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16516:SF4">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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            <begin position="367"/>
            <end position="395"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001699-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="471" mass="50949" checksum="CE682D157737ECB4" modified="2016-09-07" version="1">MTMDVKQSRMNVKIAPPIPDQQDHQLLHQHVTPTKMAERKSTTGTKRSFDVAFLMLPDEKLTAARNGRTAKRQIPPAPSSPTIDVESDSTQSEDLSVKGGFSPIRSPEVERHFSLDVLSAGRQRALLVDGLTTAHATPLVHHPQQPHGHQQPHPHSHPHPHQQHLQHPGSEERLAYLFNSGARFYEHPFGAFGRSDADTQRSAFQKVSSVMPTGSPLPPLSPDRHSCPSTSPPISLSPSGSHTGSVGGFRTYEYGPFLSPSPGSSPSAAPAGSTRSVSPAAKPPTGPGAPPLPAMLYRPTDPNEPPMPGTPYFPGVPPFALPPFTTGPAAPAIPEAVDGIIRNPAAAAILSTLLPSAMSTFTLSAQNVCAKCNISFRMTSDLVYHMRSHHKSEHVHDHARRKREDKLKCPVCNESFRERHHLTRHMTAHQDKAGDLLEKTPSAGVNGKGAAARHQHQHQQHLHVASPGRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4G3</accession>
    <name>A0A182P4G3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ak2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182P4G3"/>
    <dbReference type="STRING" id="199890.A0A182P4G3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001799-RA">
        <property type="protein sequence ID" value="AEPI001799-PA"/>
        <property type="gene ID" value="AEPI001799"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001799"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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            <begin position="28"/>
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            <name>ATP</name>
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            <name>AMP</name>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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    </evidence>
    <sequence length="240" mass="26407" checksum="FCF4137B34D9939A" modified="2016-09-07" version="1">MAPNATEPKVNPASSPTGINAILLGPPGSGKGTQAPLLKEKYCVCHLSTGDMLRAEIASGSKLGAQLKKVMDEGKLVSDELVVDMIDSNLDKPECRNGFLLDGFPRTVVQAEKLDNLLEKRNTGLDAVIEFGIDDSLLVRRITGRLIHQASGRSYHEEFAPPKVPMRDDVTGEPLMRRSDDNAQALVKRLESYHRQTKPLADYYALRGLHFRVDAAKSTSDVFSNIDSIFIKQRAHRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4G7</accession>
    <name>A0A182P4G7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="AEPI001803"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001803"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0070161">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SH3_domain"/>
    </dbReference>
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        <property type="entry name" value="SoHo_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3_9"/>
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        <location>
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            <end position="2733"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001803-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="3257" mass="366523" checksum="FCDF0A1352A2BA1B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4S4</accession>
    <name>A0A182P4S4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin-K</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4S4"/>
    <dbReference type="STRING" id="199890.A0A182P4S4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001910-RA">
        <property type="protein sequence ID" value="AEPI001910-PA"/>
        <property type="gene ID" value="AEPI001910"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001910"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20530">
        <property type="entry name" value="CYCLIN_CCNK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20531">
        <property type="entry name" value="CYCLIN_CCNK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000018">
        <property type="entry name" value="Cyclin-K (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000021">
        <property type="entry name" value="Cyclin-K (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 11" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="14">
        <location>
            <begin position="138"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="142"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="321"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001910-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="376" mass="42934" checksum="97B515A683DA3A4A" modified="2016-09-07" version="1">MPNWYYDKKDLRNTPSARDGVDYETERRYRREGARFIMEAGASMSLGHNTVATGVVYFHRFYMFHSFRTFPRFVTASCCLFLAGKVEETPKKCKDIIKTARGLLSDEKFQSFGEDPKEEVMTLERILLQTIKFDLQVEHPYSFLVKYAKCLKGDSAKLQKMVQMAWNFVNDSLSTTVSIQWEPEIIAVALIYLASKLSKFTVVDWVGKRPEHLKWWDMFVQDVTMDILEEICHQVLDLYQPSQAESAPQKSPPQLPPSKASPPMKRANISPITNKNSPNIAVKTPLPPMPPTEVEANPIPKHITTENPHYPYPPYPMHPVPPIPPQGHGPPPPYGTMPPVMPPQPPQAWQHYPHPNANKYYPPGPPPGRNPYYPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P507</accession>
    <name>A0A182P507_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the TOPBP1 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P507"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001994-RA">
        <property type="protein sequence ID" value="AEPI001994-PA"/>
        <property type="gene ID" value="AEPI001994"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001994"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17738">
        <property type="entry name" value="BRCT_TopBP1_rpt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17728">
        <property type="entry name" value="BRCT_TopBP1_rpt8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000018">
        <property type="entry name" value="DNA topoisomerase 2-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000118">
        <property type="entry name" value="DNA topoisomerase 2-binding protein 1-A-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000010">
        <property type="entry name" value="DNA topoisomerase II binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000020">
        <property type="entry name" value="DNA topoisomerase II binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049542">
        <property type="entry name" value="TopBP1-like_BRCT0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049936">
        <property type="entry name" value="TopBP1_BRCT_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21298">
        <property type="entry name" value="TopBP1_BRCT0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="114"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="208"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="396"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="596"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="691"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="485"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="936"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1017"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1075"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1141"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1314"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1075"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1142"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1186"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1219"/>
            <end position="1237"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1314"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1325"/>
            <end position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001994-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1569" mass="172386" checksum="E6A51C5464714F71" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5D9</accession>
    <name>A0A182P5D9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="STRING" id="199890.A0A182P5D9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002129-RA">
        <property type="protein sequence ID" value="AEPI002129-PA"/>
        <property type="gene ID" value="AEPI002129"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002129"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01379">
        <property type="entry name" value="MYSc_Myo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06608">
        <property type="entry name" value="STKc_myosinIII_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000010">
        <property type="entry name" value="Myosin IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000421">
        <property type="entry name" value="Serine/threonine-protein kinase PAK 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036083">
        <property type="entry name" value="MYSc_Myo3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF3">
        <property type="entry name" value="MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 21" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 21" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13 21" id="KW-0518">Myosin</keyword>
    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0844">Vision</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="26">
        <location>
            <begin position="340"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="21">
        <location>
            <begin position="926"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1427"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1471"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1697"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1787"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1850"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="1089"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1526"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1555"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1580"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1697"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1794"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1806"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="1871"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="433"/>
            <end position="440"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002129-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1882" mass="215003" checksum="E61FEDB628959525" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P674</accession>
    <name>A0A182P674_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P674"/>
    <dbReference type="STRING" id="199890.A0A182P674"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002422-RA">
        <property type="protein sequence ID" value="AEPI002422-PA"/>
        <property type="gene ID" value="AEPI002422"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002422"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000020">
        <property type="entry name" value="Protoheme ix farnesyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002422-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="511" mass="54573" checksum="FC976A0DCBAA7905" modified="2016-09-07" version="1">MHKFLANGRLWCDLVRQAGPRTSGRPPFVFCSRLDTTGTTTSCAAVPLLTIRKQHSGSNEGDTAPFGSRGATKTAAVHQPVAVPLAVPLSVVPPVVDAQALVSEISKSVGLPAGSTLRKSIKASSADGTKEEPVVASVTSLPGLSRLIYHYLMLSKIRLTSLVVMTAMAGYAMAPGSFELGTFLLCSAGTTLVSGAANSINQVIETSFDAQMARTRNRVLVKGHLSRLHAVGFALGASTIGCSMLYFGVNEMTAALGAANLILYTSIYTPMKRYSILNTWVGSVVGAIPPLMGWAACTGGDLGAGAWILAGLLYCWQFPHFNALSWNIRPEYLKAGYKMMANSHPALCTRVSLRHTGFITGLSLLAPVLDVTNAWFALETLPLNAYFAYLAWDFHQKADSKSSRKLFRFSLLHLPLLMALFLLNKKHWQFREDKQKKATDEAVEFGQAGAIATGVFVSGGDTGEQRSEYLVPNIVADIGAPAPSPGSIKAIEDSLLSNVATVLPTPGKQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6T3</accession>
    <name>A0A182P6T3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myofilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6T3"/>
    <dbReference type="STRING" id="199890.A0A182P6T3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002633-RA">
        <property type="protein sequence ID" value="AEPI002633-PA"/>
        <property type="gene ID" value="AEPI002633"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002633"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031828">
        <property type="entry name" value="Myofilin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15929">
        <property type="entry name" value="Myofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002633-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10903" checksum="FE220BEB2CD53270" modified="2016-09-07" version="1">MFKSHLEMIGSYEPISKKARFFNTYLKSLKGSQDIMAKEKRSYSSSFESQSIYSDSKFACERVKSPGYHYNPVSKDTYGVTPRKINARDFTTMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6Y6</accession>
    <name>A0A182P6Y6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane-bound transcription factor site-2 protease</fullName>
            <ecNumber evidence="3">3.4.24.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endopeptidase S2P</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site 477-DRSRILL-|-CVLTFLCLSFNPLTSLLQWGGA-505. The residues Asn-Pro, 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced.</text>
            <dbReference type="EC" id="3.4.24.85"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.24.85" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P6Y6"/>
    <dbReference type="STRING" id="199890.A0A182P6Y6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002686-RA">
        <property type="protein sequence ID" value="AEPI002686-PA"/>
        <property type="gene ID" value="AEPI002686"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002686"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="11">
        <location>
            <begin position="118"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002686-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="484" mass="53891" checksum="8AC15C00475BDD53" modified="2016-09-07" version="1">MHYPYDAFLRGTGLTVKFLRLQWHTTALNRSIVKWSTKYPKILDCSFNAGVYLSLVLMPFAVAMIVVSSLQTNLHGQSARVVASGGAGNGDSRAPARRMVEIDLVVPGVNLPINEIGYYIAALAINSIVHELGHGLAAVLEDVQIRGFGLHVLLIIPMAYTQLDSDQLNTLRLWKKLRVLCAGIWHNLVLGLLTYLLFISTPFLFSSLYRTSDGVIVTALKNNSPMAGSRGLEHGDIIKSINSCEIQHEESWFDCLLHTIHSPPAYCVSTDFVHLNDESVPMSHKNDGLIECCDSKNTASSCFEYMVDANEDDVALPQHMCLNIRKTIENSFGYCQHNGQCSEGHCFRPSINNYTTIMQIRRESKPDVIYIGHPGDATRTVHISRFIPKTGLFAPRFADSIQLLLKYVTVFAIGLAFINIMPCYGFDGQHIVNALLSDGSIQQRIPQKNKRDMISLAVNVIGTLFVFILLMKVFWLSLSRVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7N6</accession>
    <name>A0A182P7N6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 25">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="25">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate + ATP = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60148"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:60149"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="22 25">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="24">Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with PCM1, CSTPP1 and LRRC49.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 25">Mitochondrion inner membrane</location>
            <topology evidence="2 25">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin polyglutamylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7N6"/>
    <dbReference type="STRING" id="199890.A0A182P7N6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002939-RA">
        <property type="protein sequence ID" value="AEPI002939-PA"/>
        <property type="gene ID" value="AEPI002939"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002939"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000033">
        <property type="entry name" value="Probable tubulin polyglutamylase TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF31">
        <property type="entry name" value="POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="20" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15 25" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="18 25" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 25" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 25" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 25" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002939-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="466" mass="53669" checksum="A0DF2F86C5FBE723" modified="2016-09-07" version="1">MGHGFGELAKVRGIVTHKISPFEQRAFANVISKGIPNTLRRIRSQVFIVAPRHERVKICFCTDLDKSVLISNFEKRGWVQVTADDDWNFYWAGTGTCRNIFSVDSGYRMHDNQLINHFPNHYELSRKDLLVKNIKRYRKDLERDGNPLAEKTEANIPGGSKYLYLDFIPITFVLPADYNMFVEEYRKNPQSTWIMKPCGKSQGAGIFLINKLSKLKRWSREAKTSFHPQIGKESYVISRYIENPLLIGGKKFDLRLYVLVTSFRPLKAYLFRLGFCRFCTVKYDTSVTELDNMYVHLTNVSVQKHGGEYNNHHGGKWSVQNLRLYLEGTRGKEVTDKLFGSITWLIVHSLKAVSSVMASDRHCFECYGYDIIIDNTLKPWLVEVNASPSLTSTTANDRILKYKLIDNILNIVLPPDGVPDVRWNKIPSPDMLGNFDLLIDEEIAAQDDNMQNSNNGKHRSNNNRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P843</accession>
    <name>A0A182P843_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="199890.A0A182P843"/>
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        <property type="protein sequence ID" value="AEPI003096-PA"/>
        <property type="gene ID" value="AEPI003096"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="protein SON isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dsRBD_dom"/>
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        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dsrm"/>
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    </dbReference>
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        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="837"/>
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        </location>
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            <begin position="140"/>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003096-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="944" mass="105110" checksum="1E94C3F44C85879F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P852</accession>
    <name>A0A182P852_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P852"/>
    <dbReference type="STRING" id="199890.A0A182P852"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003105-RA">
        <property type="protein sequence ID" value="AEPI003105-PA"/>
        <property type="gene ID" value="AEPI003105"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003105"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38337">
        <property type="entry name" value="AGAP010540-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38337:SF1">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003105-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="85" mass="9368" checksum="9B6A39E2D0697A54" modified="2016-09-07" version="1">MAASLTVACRQTQSCGHLISIRPFVHRNTSSEDLNTVLLYASSLKMSAKLFRMPVSAHYLCFLVLVCFIGVLTFGMCLNISLGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8P4</accession>
    <name>A0A182P8P4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EF-hand domain-containing family member C2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8P4"/>
    <dbReference type="STRING" id="199890.A0A182P8P4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003298-RA">
        <property type="protein sequence ID" value="AEPI003298-PA"/>
        <property type="gene ID" value="AEPI003298"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003298"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010975">
        <property type="term" value="P:regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000002">
        <property type="entry name" value="EF-hand domain (C-terminal) containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000001">
        <property type="entry name" value="EF-hand domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000004">
        <property type="entry name" value="EF-hand domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF11">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="11">
        <location>
            <begin position="80"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="11">
        <location>
            <begin position="231"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="11">
        <location>
            <begin position="433"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="681"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003298-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="762" mass="87357" checksum="C5A5393ED263862B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P963</accession>
    <name>A0A182P963_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P963"/>
    <dbReference type="STRING" id="199890.A0A182P963"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003467-RA">
        <property type="protein sequence ID" value="AEPI003467-PA"/>
        <property type="gene ID" value="AEPI003467"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003467"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130983" description="Ketoreductase domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="464"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003467-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="741" mass="77451" checksum="5F4A90707B003A43" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9P5</accession>
    <name>A0A182P9P5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein hook</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in endocytic trafficking. Probably acts as a cytoskeletal linker protein that tethers endosome vesicles to the cytoskeleton.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with microtubules via its N-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the hook family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9P5"/>
    <dbReference type="STRING" id="199890.A0A182P9P5"/>
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        <property type="protein sequence ID" value="AEPI003650-PA"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
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    <name>A0A182P9Q7_9DIPT</name>
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            <fullName evidence="6">ARID domain-containing protein</fullName>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">Epiroticus2</strain>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="7">Epiroticus2</strain>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1311"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1327"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1339"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1354"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1375"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1452"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1471"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1507"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1555"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1585"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1643"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2034"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2070"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2141"/>
            <end position="2159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2168"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2191"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2634"/>
            <end position="2651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2655"/>
            <end position="2667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003661-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2707" mass="286024" checksum="C82CE31F61F5CA0B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9U2</accession>
    <name>A0A182P9U2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9U2"/>
    <dbReference type="STRING" id="199890.A0A182P9U2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003696-RA">
        <property type="protein sequence ID" value="AEPI003696-PA"/>
        <property type="gene ID" value="AEPI003696"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003696"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13329">
        <property type="entry name" value="PH_RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872:SF2">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="132"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003696-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="467" mass="51754" checksum="6534A49838BA2F81" modified="2016-09-07" version="1">DEQNEASSLANNNYSSSSTSSLPLALDSRSTSMEAVGGGATTAVSSAGPAGTVSGINPTHSPGGVLPASASTTSGTSVSHGLSGQGSGPGGLLNVPTAREWIDSEDEEAPEAVWSSNIPPEILSSIGNLEKERQEVINEICHTERKHVRTLRLLEGMFMRPLQESGALPHDLLNLLFPHSLIHLKDLHTAFEQKLKQRRSEHGTIIREIGDLLLYMFDGQTGDELKEHAAHFCARQQIALEALKERRKKDEQLQRLLTKAESHKACRRLQLKDLLPTVLQRLTKYPLLFDKLYNFTERSSTKHESEALAIQKALESAKRILDHVNQAVRIEEDMHKLQTIQRKLDKSGLDKEASVEFKNIDLTVRKLIHDGPLTMKKNPGVQLHGLLFEDIMVLLQKQDDKYLVKYHSSPGLGSESKHAEGRFNPITKIHLILVRQSAVDKNTFFLINTNVSQMLELTAPSSTECKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAR0</accession>
    <name>A0A182PAR0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="12">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="12"/>
    <dbReference type="STRING" id="199890.A0A182PAR0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004015-RA">
        <property type="protein sequence ID" value="AEPI004015-PA"/>
        <property type="gene ID" value="AEPI004015"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004015"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000212">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000293">
        <property type="entry name" value="ATP binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005292">
        <property type="entry name" value="MRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00957">
        <property type="entry name" value="MRP_assoc_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1031"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1129"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1218"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="351"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="663"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="991"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="1306"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="920"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="939"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004015-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1546" mass="172606" checksum="F94943D67FE1AE2B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBZ4</accession>
    <name>A0A182PBZ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 141</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBZ4"/>
    <dbReference type="STRING" id="199890.A0A182PBZ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004450-RA">
        <property type="protein sequence ID" value="AEPI004450-PA"/>
        <property type="gene ID" value="AEPI004450"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004450"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3350.20">
        <property type="entry name" value="Tmem141 protein family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026788">
        <property type="entry name" value="Tmem141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038259">
        <property type="entry name" value="Tmem141_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47229">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47229:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15110">
        <property type="entry name" value="TMEM141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004450-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12710" checksum="4FB6C764A8E7C72E" modified="2016-09-07" version="1">MNDIRLLKDQQREKHPGFDSYIECMSRSLFTGLATFSLGFAGIYFLQQIGQRYLPYTKKGNILVATLVATGAAYNVTSDRTRACQARWMAVEEKYSVLQEAIEPAGPPKETII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC91</accession>
    <name>A0A182PC91_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial brown fat uncoupling protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC91"/>
    <dbReference type="STRING" id="199890.A0A182PC91"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004546-RA">
        <property type="protein sequence ID" value="AEPI004546-PA"/>
        <property type="gene ID" value="AEPI004546"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004546"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000008">
        <property type="entry name" value="Mitochondrial uncoupling protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="143"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="241"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004546-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36180" checksum="2B95DA6366E2A123" modified="2016-09-07" version="1">MSFQRRSSEKTTELTASVPVKLMTAGAAACFADFITFPLDTAKVRLQIQGEQPVRTVALAPAINTSASLKLNPTPVPATQHVQYRGLVGTITTITRQEGFRTLYNGLSAGLQRQLCFCSIRLGLYDTVKKFYGSLLKENEAGLQIGTRILAGLTTGGAAVMIAQPTDVVKVRFQAATRSSTGRRYASTLEAYRTIHREEGVRGLWRGAMPNVGRNAIVNVAEIVCYDVVKDCLLLYAHMPNDIRCHFSAAVVAGLAATIVASPVDVVKTRYMNSPRGQYRGAIDCAIRMGAKEGVAAFYKGFVPSFARLVSWNVVMWISYEQLKLVIFNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCF4</accession>
    <name>A0A182PCF4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfakinin neuropeptide</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gastrin/cholecystokinin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCF4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004609-RA">
        <property type="protein sequence ID" value="AEPI004609-PA"/>
        <property type="gene ID" value="AEPI004609"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004609"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013152">
        <property type="entry name" value="Gastrin/cholecystokinin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013259">
        <property type="entry name" value="Sulfakinin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08257">
        <property type="entry name" value="Sulfakinin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00259">
        <property type="entry name" value="GASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0027">Amidation</keyword>
    <keyword evidence="5" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131238" description="Sulfakinin neuropeptide" evidence="6">
        <location>
            <begin position="26"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004609-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20401" checksum="9C651678D1B06F39" modified="2016-09-07" version="1">MARVTLAFLVSLVAYLAYYALVTEAQPLGSLVLGHSQSNSPSLDEASDNVRLDSVKHARLKDIDIYRPRGAKIRPHDRKSSGNSGYQAYRRNMPLPVLTLKESAASTSELLPPQDTGLDVGKVDQVRFNFAGYLTDGGTLVDDDEEEDEVGLAKRFDDYGHMRFGKRGGEGDQFDDYGHMRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCU7</accession>
    <name>A0A182PCU7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCU7"/>
    <dbReference type="STRING" id="199890.A0A182PCU7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004752-RA">
        <property type="protein sequence ID" value="AEPI004752-PA"/>
        <property type="gene ID" value="AEPI004752"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004752"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004752-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="82" mass="9389" checksum="642F02686F35FEA5" modified="2016-09-07" version="1">MRASRAALQVGLSVRPETEEFCVPIELTKRLEEIRLLESRRSQRLAVQEKDTDFARLADMAGDRRRQSNSIDVPFSLTQQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCZ0</accession>
    <name>A0A182PCZ0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCZ0"/>
    <dbReference type="STRING" id="199890.A0A182PCZ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004795-RA">
        <property type="protein sequence ID" value="AEPI004795-PA"/>
        <property type="gene ID" value="AEPI004795"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004795"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016402">
        <property type="term" value="F:pristanoyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000010">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF390">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="225"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="17">
        <location>
            <begin position="372"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="15">
        <location>
            <begin position="578"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004795-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="763" mass="84734" checksum="580516471C52A7EE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD36</accession>
    <name>A0A182PD36_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Activator 1 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Activator 1 subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Replication factor C 38 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Subunit of the RFC complex, an heteropentameric complex consisting of a large subunit RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA. Forms an heterotetrameric complex with RFC2, RFC4 and RFC5; this complex has ATPase activity but is not stimulated by PCNA. The heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 interacts with RAD17. Interacts with CNTD1; this interaction facilitates crossover formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PD36"/>
    <dbReference type="STRING" id="199890.A0A182PD36"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004841-RA">
        <property type="protein sequence ID" value="AEPI004841-PA"/>
        <property type="gene ID" value="AEPI004841"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004841"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004841-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="358" mass="41348" checksum="FFC71BB26585109E" modified="2016-09-07" version="1">MSLWVDRYRPRELSRLDYHKQQANQLINLCSQGDFPHLMFYGPSGAGKKTRIICLLRELYGPGVERLRNEVMNFTTPSNKKIEIMTVSSNYHIEVNPSDVGIYDRVVITDMIKQIAQTQQIDPTGQREFKTIVLSEVDELTKDAQHALRRTMEKYVATCRLILCVNSTSRIIPAVKSRCLGIRVSAPTEDEIVSVMNSICKKESLHIPPELATRIAQKSERNLRRAILTLEACKVMQYPFTANQEIPDMDWQTYLKETANMIVQEQTPQRMEVVRERLYELLSQGIPPYIIFKGLVEILVKNCDMSLKSQTLSFAGLYDHRMQRGSKHIFHLEAFVAQFMALYKKFLNQVSVMDMDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEA1</accession>
    <name>A0A182PEA1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEA1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005256-RA">
        <property type="protein sequence ID" value="AEPI005256-PA"/>
        <property type="gene ID" value="AEPI005256"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005256"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005256-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="38308" checksum="C53F95793F6AABB7" modified="2016-09-07" version="1">MQADSQQRNTRHTFSATEGHVGTLLSDPFQIQSVAAHRSGFSDRPVFRPSGRSEQTSSFAEPKARLAPPKLTTTDLLDALARFTYFDRWSDEQRRDCCHRAQIRQFDPDQTVFVEGQAPVNYAHFMLSGECGLLQCLRLHRRRDRRTGTVRYRLTRAQPTEDEITRFHRRRAQATDPEQVGSSATVPAEPRPRKPLDGRLEYHFVDIATYSRGSVFGVGEHMVDRAVFARTAVQCLLIPRYWLLEKPQNRGNIWNRIRIFLEQRQPSRDRLFRWFLTELLWHRYRHQLVDDFRLVHAPRHLPRLHDVPLVCRIEECDVQQQQRDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEN5</accession>
    <name>A0A182PEN5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAB6-interacting golgin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GORAB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEN5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005390-RA">
        <property type="protein sequence ID" value="AEPI005390-PA"/>
        <property type="gene ID" value="AEPI005390"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005390"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007033">
        <property type="entry name" value="GORAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21470:SF2">
        <property type="entry name" value="RAB6-INTERACTING GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21470">
        <property type="entry name" value="RAB6-INTERACTING PROTEIN GORAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="724"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="840"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005390-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1002" mass="115436" checksum="99ED2C788DEC64E9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEU6</accession>
    <name>A0A182PEU6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEU6"/>
    <dbReference type="STRING" id="199890.A0A182PEU6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005451-RA">
        <property type="protein sequence ID" value="AEPI005451-PA"/>
        <property type="gene ID" value="AEPI005451"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005451"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000033">
        <property type="entry name" value="Polycomb group RING finger protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825:SF29">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="123"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005451-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="173" mass="17929" checksum="6AD303CA0DAE5503" modified="2016-09-07" version="1">MVLLPHSDVLSGDALSASTEMASEGTPVVKVSAPPPPAVAAGATNTNTTTTTTTTTTATSDTPPPLAISISTTTTVTTATPNASSTDDVTAATAASMYGSAGPLSPYRPSRVKLGSVYPCITCNLCKGYLIDATTIVECLHSFCHSCIMKHLRTEQYCPQCEMMINKAKPNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFC5</accession>
    <name>A0A182PFC5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PFC5"/>
    <dbReference type="STRING" id="199890.A0A182PFC5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005631-RA">
        <property type="protein sequence ID" value="AEPI005631-PA"/>
        <property type="gene ID" value="AEPI005631"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005631"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="486"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="835"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005631-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="898" mass="101641" checksum="6D260B727940E9B5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFM1</accession>
    <name>A0A182PFM1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PFM1"/>
    <dbReference type="STRING" id="199890.A0A182PFM1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005728-RA">
        <property type="protein sequence ID" value="AEPI005728-PA"/>
        <property type="gene ID" value="AEPI005728"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005728"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000004">
        <property type="entry name" value="Chitinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF360">
        <property type="entry name" value="CHITINASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131241" description="chitinase" evidence="14">
        <location>
            <begin position="25"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="44"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="15">
        <location>
            <begin position="443"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="386"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005728-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="506" mass="55590" checksum="00E4DB5543CC96E6" modified="2016-09-07" version="1">MVERARVFGAVLLVLVIAITVGRAEEDQPKDRAEGDYFGAIRRKKVVCYVGTWAVYRHGNGRFDIDHIDPRLCTHLMYGFFGINEDATVRIIDPYLDLEENWGRGHIRRFVALKNAVPQLKTLAAIGGWNEGSRKFSAMAASPELRKRFIYDCVAFCQRHGFDGVDLDWEYPAQRDGNPLIDRDNHAQLVEEMRVVISKSFHFLNVMVYDMHGAWDSYCGINAPLYRGPADTTGKQVQLNVNASIQYWLAQGAPAEKLVLGIPLYGRSFTLANAGNTQVGAPAVGGGTPGPYTGEPGVMGYNEFCEKLQTESWDLRWSEEQQVPYAVRNNQWLGYDDLRSVQLKVKFLLEQGLGGAMVWSLETDDFRGLCGGGRYPLMNEIRSLLNGGAPSPTTTLTPSPAPITTTGTMGPTPDVTSSTASDAEPGSTEGSTPPGTTNPPSLNGPCANGKSGFVPHPKHCNQYYICLTADTYFEFTCPAGTLFDPDLNVCNWADQVSCIDKSSESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFQ8</accession>
    <name>A0A182PFQ8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="3">Epiroticus2</strain>
        </source>
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        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
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        <property type="gene ID" value="AEPI005765"/>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="603"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005765-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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            <strain evidence="9">Epiroticus2</strain>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Wortman J."/>
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            <strain evidence="3">Epiroticus2</strain>
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        </citation>
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        <source>
            <strain evidence="2">Epiroticus2</strain>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIC4"/>
    <dbReference type="STRING" id="199890.A0A182PIC4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006686-RA">
        <property type="protein sequence ID" value="AEPI006686-PA"/>
        <property type="gene ID" value="AEPI006686"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006686"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF48">
        <property type="entry name" value="GH09711P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="7">
        <location>
            <begin position="375"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006686-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="84853" checksum="ADC338658F09784E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIF4</accession>
    <name>A0A182PIF4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIF4"/>
    <dbReference type="STRING" id="199890.A0A182PIF4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006716-RA">
        <property type="protein sequence ID" value="AEPI006716-PA"/>
        <property type="gene ID" value="AEPI006716"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006716"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03391">
        <property type="entry name" value="PAP2_containing_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006716-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="220" mass="25150" checksum="A91EDC3481DA22DC" modified="2016-09-07" version="1">MGESVDSKTRLEEGRNIPPALKKLLEWDVVMTKKFVSFMLNFVPVRSLRTHCKALEYSCHGIAWLAGWLAFCWMIDKPEWYQMQVNLFIGLLTDIVMVAIIKAATRRRRPAINDDPLCFGPDKFSFPSGHVSRGVFITTFLILLDPVTVLFWPPLLAWTVSLCLSRLILYRHHILDVLGGILLGLFNALLISILWFDQEGSVWLINWITDERVAGAEYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIF6</accession>
    <name>A0A182PIF6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein TsetseEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIF6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006718-RA">
        <property type="protein sequence ID" value="AEPI006718-PA"/>
        <property type="gene ID" value="AEPI006718"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006718"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131431" description="Protein TsetseEP domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006718-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="56063" checksum="0FB252ED7731BF71" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIG9</accession>
    <name>A0A182PIG9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein phosphatase inhibitor 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein phosphatase inhibitor 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIG9"/>
    <dbReference type="STRING" id="199890.A0A182PIG9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006731-RA">
        <property type="protein sequence ID" value="AEPI006731-PA"/>
        <property type="gene ID" value="AEPI006731"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006731"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006731-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30308" checksum="81C927170D4EB225" modified="2016-09-07" version="1">MSFSSDSPDAKKPCKGILKSSSSFDKHSAASSVHRKSAKFDELNVLQTYHPPDKDYGHMKVDEPKTPFNYVESDDVDHLDAELLAERLRVAADSQSDDTWEKGVEDEDDEEEEEEELTEEQKKRKLEFERRRKAHYNEFEAVKLARKLIEEDDEDDEEDEEANKGTSSSANTANPSETGASSSTSPGKDDGTGMEIEEIEEAAGGHKAKTADSPVARLKPVSSSIILEECSNLESPRSSVIALIMIVSICLMIFFIVCFTLLFYLLKRNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIM8</accession>
    <name>A0A182PIM8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIM8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006790-RA">
        <property type="protein sequence ID" value="AEPI006790-PA"/>
        <property type="gene ID" value="AEPI006790"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006790"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006790-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="95" mass="10598" checksum="2ACA674B1A512F83" modified="2016-09-07" version="1">MLVHFQVSSAPVESNETPVSKAIALIHHLSYLIDYLVQYVIGSENDRKTPQEAADYYQTALVEGKNPGSQEASGLKPDNARARQETEIIHKMMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ45</accession>
    <name>A0A182PJ45_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJ45"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006959-RA">
        <property type="protein sequence ID" value="AEPI006959-PA"/>
        <property type="gene ID" value="AEPI006959"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006959"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131464" description="Protein sleepless" evidence="2">
        <location>
            <begin position="23"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006959-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15218" checksum="79894A6FE0A49533" modified="2016-09-07" version="1">MKSLPQRAIFALVILCIQQALSLQCYVCLSAVSFDDCSSKAMQVDCDSPPPDLPFPFAAQPMATNVAFACGKGSGSDRSGQIFVKTCVPKMSEAEFCALLTTEVGDTGKVDVCKVCNDNLCNVGSVQVLTGALLLFTVGLILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJD2</accession>
    <name>A0A182PJD2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SRP54-type proteins GTP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJD2"/>
    <dbReference type="STRING" id="199890.A0A182PJD2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007046-RA">
        <property type="protein sequence ID" value="AEPI007046-PA"/>
        <property type="gene ID" value="AEPI007046"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007046"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000004">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000015">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000188">
        <property type="entry name" value="signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="9">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007046-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="643" mass="71405" checksum="729EC4EFFA402D7E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJG8</accession>
    <name>A0A182PJG8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJG8"/>
    <dbReference type="STRING" id="199890.A0A182PJG8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007082-RA">
        <property type="protein sequence ID" value="AEPI007082-PA"/>
        <property type="gene ID" value="AEPI007082"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007082"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF104">
        <property type="entry name" value="CYTOCHROME P450 308A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007082-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39953" checksum="1B02506BA47E2896" modified="2016-09-07" version="1">MESVADAFVTFIGRQVGQELEAKEIAARFTTQNVVACTFSIDGDCFAERESEFRRMGRRVFETSHMATAKTMMAVFLPTVAKYIPVPFLLKDVDEWIRSLVANLIIQRSATEGTVKEDLLQSFLKNREKSNATQTEITAHALTIFLEGFETSSVVLGFALYRLAKSPEVQRKLHEELKSKIDANGGRLDFDVMQQLDYLDWVMLETLRMHPPAATMHKVCTKKYIMRKGFRDEAGNDMGVYVREGTPILIPVLAIHMDPKYYPEPHIFNPERFNPERKVTHNGAIFLPFGDGPRMCLGMRFAQAQVKLAMVRLILNYRVAVGPNDKPFAVDSRSFVYQARDGLRIKFERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJS2</accession>
    <name>A0A182PJS2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PJS2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007187-RA">
        <property type="protein sequence ID" value="AEPI007187-PA"/>
        <property type="gene ID" value="AEPI007187"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007187"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0022857">
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>IDENTIFICATION</scope>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007300-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1598" mass="179620" checksum="7D1A60CB9E451799" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK79</accession>
    <name>A0A182PK79_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PK79"/>
    <dbReference type="STRING" id="199890.A0A182PK79"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007345-RA">
        <property type="protein sequence ID" value="AEPI007345-PA"/>
        <property type="gene ID" value="AEPI007345"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007345"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000063">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007345-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="275" mass="30726" checksum="6AB754EDF9EE8C09" modified="2016-09-07" version="1">MFRNQYDSDVTVWSPQGRLHQVEYAMEAVKLGSATVGLKNKDYAVLIALKRASSELSSYQKKIISIDDHLGLSFAGITADARILSRYLRQECLNYKYAYDAFYPVGRLISNLGNKMQVCTQRYDRRPYGVGLLVIGYDDQGPHIYQTCPSANFFDCKAMSIGSRSQSARTYLEKHLATFPDCTKDELIRHGVQALQDTLPNEVELNNKNISIAIVGKDENFHVLEEQENDKYLSNIVRRGGAAPETAAGSQPPRDDGDDQPPNVPDPIPVVAMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK93</accession>
    <name>A0A182PK93_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PK93"/>
    <dbReference type="STRING" id="199890.A0A182PK93"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007359-RA">
        <property type="protein sequence ID" value="AEPI007359-PA"/>
        <property type="gene ID" value="AEPI007359"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007359"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="5">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="80"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007359-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26940" checksum="97647D116A5EA2A7" modified="2016-09-07" version="1">MTSMTFGQKKFIPTAPEKGSFPLDHGGQCRKLMLFYMRCLRENADDNSACREESKAYLQCRMDNDLMAREDFSKLGYRDLELDVHVIVTEHAQHFFSPSELPATVTLHTDAEEWTSWQKRGDPVLHIELGKWADLLVIAPLDANSLAKMATGLCDNLLLCTTRAWDPAKPLIFCPAMNTRMWEHPITAAQISTLKSWGHREIPCIAKTLMCGDTGYGAMAEVNTIVSTIRDTLLLMEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK95</accession>
    <name>A0A182PK95_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PK95"/>
    <dbReference type="STRING" id="199890.A0A182PK95"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007361-RA">
        <property type="protein sequence ID" value="AEPI007361-PA"/>
        <property type="gene ID" value="AEPI007361"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007361"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007361-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26052" checksum="CDB52F5D18BE0C83" modified="2016-09-07" version="1">MMNEETSSPASSNVVAQFFKRLGQLYQLQLDKWTPHTKVRWAAALGLIGLFLLRVFTKQGWYIVTYALGIYHLNLFIAFLTPKIDPALDLDDDQGPELPTRSNEEFRPFIRRLPEFKFWYAISKSTVIGIVCTFFDMFNVPVFWPILVLYFITLFCITMKRQIKHMIKYRYLPFTHTSSSSLSSSSSSSVGGSVAPAVAAAATPFPAVAVPQVLAGVHPSAVGGGMPSSSSVSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKC5</accession>
    <name>A0A182PKC5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleosome assembly protein 1-like 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKC5"/>
    <dbReference type="STRING" id="199890.A0A182PKC5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007391-RA">
        <property type="protein sequence ID" value="AEPI007391-PA"/>
        <property type="gene ID" value="AEPI007391"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007391"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007391-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="46906" checksum="1873B23959227EC6" modified="2016-09-07" version="1">MTTGAKTESECEVPDFVDAPGYLDAFSRRYMMKQFIQSLPEAAQKRVNALKHLQVEYTKLEAKFFEEVYQLECKYQQLYQPIVDRRKEIVSGKADPTPEEAVWVDPPRKKEEGDEEEEQEEEDDEINEKLKKMALNYHKELPANGQGIPNFWLMVFKNTEALAELVHPHDEPVLEYLRNLNIVYEKEPMSYVIEFHFDPNPYFKDTVLTKKYFLRCNIDKDEPFGFEGPEIFKCTGCPINWNPGKNVTVKTIKKQQKHKQRNATRMVMKTQPTESFFNFFSPPRIQEDDAIDPETQFLIGRDFEVGHFLRARIIPKAVLYYTGEVMDDEDDDDDDEEEEEEEEDEEMEEGEEEEEEDDDDDDDEDNAPKPPAQPSNRAKKAKGGRGAGGGGGGKKGEQPPECNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKD5</accession>
    <name>A0A182PKD5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L17, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKD5"/>
    <dbReference type="STRING" id="199890.A0A182PKD5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007402-RA">
        <property type="protein sequence ID" value="AEPI007402-PA"/>
        <property type="gene ID" value="AEPI007402"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007402"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.10:FF:000009">
        <property type="entry name" value="39S ribosomal protein L17, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007402-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="201" mass="23148" checksum="46E670F04BCA8D3B" modified="2016-09-07" version="1">MNQAEVTKLMSQLRVAIRPRHRNLKNIDGPEGRLNKLRKTVTALVKHERIELNYQRADEARGYAERLISDAIRHGDCHKPTMEMADYWLLEKQLVHKLFKVLVPRFEEYKVSATRMYKAPKEYPGWYRKRAVLELRGNPYPPLLPNQSNNRNLLHNVLMDEAKKDYRREKYAEIAAQIGTEGTGGLVGEPAGASSEQPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKJ6</accession>
    <name>A0A182PKJ6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKJ6"/>
    <dbReference type="STRING" id="199890.A0A182PKJ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007463-RA">
        <property type="protein sequence ID" value="AEPI007463-PA"/>
        <property type="gene ID" value="AEPI007463"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007463"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF186">
        <property type="entry name" value="NEUROCALCIN HOMOLOG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007463-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="205" mass="23569" checksum="4A938C8E957EB179" modified="2016-09-07" version="1">MATPPDSPIEEVVYELEPTRAPKPIPVALEDLCRLTKFTRQEIRVMYRGFKTECPDGVVHEDSFKDIYAKFFPHGNSSLYAHYVFKAFDVNCNGSITFRDLLVTLSTLLRGSVYERLRWTFRLYDINGDGCISRGELGEIISAVHELMGRRPHQPDDDRKAREQVDRVFAKLDLNQDGIITIEEFLEACLKDDVVTKSLQMFDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKZ4</accession>
    <name>A0A182PKZ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKZ4"/>
    <dbReference type="STRING" id="199890.A0A182PKZ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007611-RA">
        <property type="protein sequence ID" value="AEPI007611-PA"/>
        <property type="gene ID" value="AEPI007611"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007611"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="138"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007611-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="290" mass="34070" checksum="DEAEB8FF005CDB2F" modified="2016-09-07" version="1">MALVARVMEPIVETRAMIGSAVEQRWNALLDVIGDDPDFLYTWGLTVYVHTFFWVVGGLFVLMDLTNRPAFLRRYKTQPGKNEPIAWNDLWRVMRTIFFNQTVVGIPLTFVGYHATIKGTVPDVRILPSIDVILRDLVVCVFFAEVGFYYVHRFLHIKPLYKLIHKKHHEWTAPFAWTAMYCHPIEHIISNMIPPMIGIQLMRAHVFTTAIWFPLVIFNTIRDHCGYHLPFFPSSEYHDYHHAKFTECFGTFGYLDWLHGTDTKFRKSKQHQRHRTLWGIKSARELYPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL06</accession>
    <name>A0A182PL06_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Aminopeptidase</fullName>
            <ecNumber evidence="20">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 20">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 20">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A182PL06"/>
    <dbReference type="STRING" id="199890.A0A182PL06"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007623-RA">
        <property type="protein sequence ID" value="AEPI007623-PA"/>
        <property type="gene ID" value="AEPI007623"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007623"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000008">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000007">
        <property type="entry name" value="thyrotropin-releasing hormone-degrading ectoenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminopeptidase_N-like_N"/>
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        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
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        <property type="entry name" value="ERAP1-like_C_dom"/>
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        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF253">
        <property type="entry name" value="AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 20" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 20" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11 18 20" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="23">
        <location>
            <begin position="36"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="21">
        <location>
            <begin position="271"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="22">
        <location>
            <begin position="586"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="19">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007623-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="922" mass="106771" checksum="A80BF6E67052EB01" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL17</accession>
    <name>A0A182PL17_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="STRING" id="199890.A0A182PL17"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007634-RA">
        <property type="protein sequence ID" value="AEPI007634-PA"/>
        <property type="gene ID" value="AEPI007634"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007634"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14513">
        <property type="entry name" value="DSP_slingshot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043588">
        <property type="entry name" value="SSH-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23040">
        <property type="entry name" value="PH_SSH1-like_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="12">
        <location>
            <begin position="442"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="501"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="563"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="649"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="726"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="971"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1088"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1229"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1404"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1441"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1499"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1617"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="974"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1231"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1476"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1499"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1620"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1665"/>
            <end position="1682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007634-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1779" mass="189836" checksum="0214BC3D96AB6917" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL27</accession>
    <name>A0A182PL27_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Osteopetrosis-associated transmembrane protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PL27"/>
    <dbReference type="STRING" id="199890.A0A182PL27"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007644-RA">
        <property type="protein sequence ID" value="AEPI007644-PA"/>
        <property type="gene ID" value="AEPI007644"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007644"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019172">
        <property type="entry name" value="Osteopetrosis-assoc_TM_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15644">
        <property type="entry name" value="OSTEOPETROSIS ASSOCIATED TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15644:SF2">
        <property type="entry name" value="OSTEOPETROSIS-ASSOCIATED TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09777">
        <property type="entry name" value="OSTMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007644-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38387" checksum="172D87842A07E3EE" modified="2016-09-07" version="1">MPQMIACCFWTATGDQECEDIHLFLKYGGKMMVALPMHTYPVFNVCTSQLVINDYHMAIEHYQNMTKSPICQKYLTSNRMNVYETIYNLLTGMWNDANCDACANAVNETATFMNMSSVLERCIAINSADPCEKCADDYQRVQQYYAKLDKEGHGPDRLCFDIADRMNKTRRSWSGTYNCCHDKRHSMVIFSVIASVVCTLPVLFYAVMHLVTVRQEARRISLLSASSGHEDRPQHFSSSRPYHGVLRQPEMERIVETLDGDEDEGAESQESDNESDEGVGGVKKLALLSPDPTEINNLDVKESKLINVSGLDHQMPSQSATCITKVNQPQNCSHDESLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLH6</accession>
    <name>A0A182PLH6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubulin polyglutamylase ttll-15</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLH6"/>
    <dbReference type="STRING" id="199890.A0A182PLH6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007796-RA">
        <property type="protein sequence ID" value="AEPI007796-PA"/>
        <property type="gene ID" value="AEPI007796"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007796"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053317">
        <property type="entry name" value="Tubulin_polyglutamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47113">
        <property type="entry name" value="LD09343P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47113:SF1">
        <property type="entry name" value="LD09343P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007796-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="63007" checksum="1EECE6CA177C0B17" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLJ8</accession>
    <name>A0A182PLJ8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLJ8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007818-RA">
        <property type="protein sequence ID" value="AEPI007818-PA"/>
        <property type="gene ID" value="AEPI007818"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007818"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007818-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="351" mass="37806" checksum="4E31B30C52446570" modified="2016-09-07" version="1">MQLMTFNSLLMFDIVFIFFLFLVGVTCLVYYLPPRELTPHDAPAHHHPHHQSSCFSSSSAATQDAFPSPGSGGPVVRGCASAARRISGEGGTPIILVGVRSEAEQQQQEPAQHRSPPPASRYARALTADSVDPAVPEPGAPYLPPAAYPLRSDEQEVLLLDCTLEDLIVLQQMAGEGAGAGVGGGLGIGEMRLSRAAGSEPCRNCCCQYQPSADRWSAPPAVMSPIVVPLPATPPPPPRRRTVGRPAELLPFPTMTRNDGEPEEHDEGDDEDEGELEMEEAYQRQQQQQQQHHRVEYVRIEIERRGSTVGKGSATTANPAAGGEPMSMPACCYVRAKDTDIRACSGPIHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLN1</accession>
    <name>A0A182PLN1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein phosphatase 1 regulatory subunit 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLN1"/>
    <dbReference type="STRING" id="199890.A0A182PLN1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007851-RA">
        <property type="protein sequence ID" value="AEPI007851-PA"/>
        <property type="gene ID" value="AEPI007851"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007851"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000055">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007851-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="38074" checksum="14DC7E8B5713AB88" modified="2016-09-07" version="1">MSTNEEQQEQPPRADSPTVDEERPPGAGEVAEHEIVKMEDVITIDPETTEVDLNHGRIGKIENLEPLTKLERLYLRWNLIKKIENLDHLTSLLELELYDNQITELENLDNLVNLEMLDVSFNRLSQIKNLSALTNLRKLFLCANRISLIENLDHFSGLTMLELGDNKIRRIENLDNLSSLTHLYLGKNKITKIENLDKLVKLECLSLQCNRLTKIENLDQLVNLTELYLSENGIEVIENLDQNKQLETLDLAKNRIKRIENIDHLELLEEFWMNDNGVSEWSCVDKLASNKNLATVYLERNPVASDVNYRRKLKLAVPWLQKIDATLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMA5</accession>
    <name>A0A182PMA5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PMA5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008078-RA">
        <property type="protein sequence ID" value="AEPI008078-PA"/>
        <property type="gene ID" value="AEPI008078"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008078"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008078-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="81" mass="8836" checksum="BF651218FF4712F4" modified="2016-09-07" version="1">QQTEKSTHSQQPLYKAGTNHSRGNETSVAGRAGRLAARSGQSNRLLDSGSQFASASEPDQTSSRSRRSVTLSRSWNKLQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PME0</accession>
    <name>A0A182PME0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PME0"/>
    <dbReference type="STRING" id="199890.A0A182PME0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008113-RA">
        <property type="protein sequence ID" value="AEPI008113-PA"/>
        <property type="gene ID" value="AEPI008113"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008113"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21312:SF28">
        <property type="entry name" value="OVOINHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21312">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131462" description="Kazal-like domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="46"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008113-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="111" mass="12197" checksum="19F35AE6D708C857" modified="2016-09-07" version="1">MMRAHLLAVSILFVVLALQSTPVRADINSEMATLVLLGGESVQARRSKDGACACPRIYDPVCGTDLSTYANRCMLDCQAEEMAARSIELRVLRRGACDEPIEEPIEDLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMZ6</accession>
    <name>A0A182PMZ6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PMZ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008320-RA">
        <property type="protein sequence ID" value="AEPI008320-PA"/>
        <property type="gene ID" value="AEPI008320"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008320"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131689" evidence="2">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008320-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="157" mass="16239" checksum="5D6EE52066960B61" modified="2016-09-07" version="1">MAHPERLLTLALAFLLVANQPLPVAAFDDFLDEIFSIFFDSESESESEEPIQVNGKHATINVMCDNCTLTINCPNCSSMAMAPMTVAPAPAPNGDSTTAAPVLVPATSTTTPMPTTTTTATTTTTTTTSAPSAGSAGNTNEDIPVNTNNAETTDPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNF4</accession>
    <name>A0A182PNF4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNF4"/>
    <dbReference type="STRING" id="199890.A0A182PNF4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008481-RA">
        <property type="protein sequence ID" value="AEPI008481-PA"/>
        <property type="gene ID" value="AEPI008481"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008481"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058999">
        <property type="entry name" value="EIF3CL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26569">
        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="672"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="879"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="896"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="925"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008481-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="968" mass="112913" checksum="73602C2705FE818E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNI3</accession>
    <name>A0A182PNI3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNI3"/>
    <dbReference type="STRING" id="199890.A0A182PNI3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008510-RA">
        <property type="protein sequence ID" value="AEPI008510-PA"/>
        <property type="gene ID" value="AEPI008510"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008510"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09377">
        <property type="entry name" value="LIM2_Lhx2_Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000177">
        <property type="entry name" value="LIM homeobox 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF168">
        <property type="entry name" value="PROTEIN APTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008510-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="151" mass="16493" checksum="0A6879E4BDA42F6A" modified="2016-09-07" version="1">MGRVFGSRRCSKCLASISSSELVMRARHLVFHIRCFSCAVCNTPLNKGDHYTIRDSAVFCRSHIELPLEAATTPLPGMPMQCPYQSQYGTSPSAPLSPSDSTASGGKLNPATYYPPHGVTGLPQQPRQKGRPRKRKPKDIEAMTASLVNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNX5</accession>
    <name>A0A182PNX5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNX5"/>
    <dbReference type="STRING" id="199890.A0A182PNX5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008654-RA">
        <property type="protein sequence ID" value="AEPI008654-PA"/>
        <property type="gene ID" value="AEPI008654"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008654"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008654-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="148" mass="16695" checksum="1E85844CEE7E7F35" modified="2016-09-07" version="1">MKDVNNFPVNGLPPLTYSSKKYTFHIEFVTFFQAWNRCRDMGKRLASIESYQDNLAYREAVAPYAGFEITFWIAATNIGARSNDQSKYYWITTDRPVGYVSGFENWFLGFVPDSANQCVATYLGSALWLTGPCATAVSAYACEESQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP49</accession>
    <name>A0A182PP49_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PP49"/>
    <dbReference type="STRING" id="199890.A0A182PP49"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008728-RA">
        <property type="protein sequence ID" value="AEPI008728-PA"/>
        <property type="gene ID" value="AEPI008728"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008728"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024857">
        <property type="entry name" value="Cappuccino"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16230:SF3">
        <property type="entry name" value="BIOGENESIS OF LYSOSOMAL ORGANELLES COMPLEX-1, SUBUNIT 4, CAPPUCCINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16230">
        <property type="entry name" value="CAPPUCCINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008728-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="189" mass="21307" checksum="54CC458E927D299D" modified="2016-09-07" version="1">MAEELAHDYSGYFKASNLDQELKPITVGIDRMMLRLEEFENLLELVKAESSVALTQNVPKLLALHPELDVLCERIDKLEKFVAMVGRNLDAVEKQVQIAEEELDIPDKTINVLLKSLNIFGKPKPAERLTNRNASGLYEPVAVFKTEQYFRPNGPEQTPVERIDEKEESENKEETVSSGGDCDTGTPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP56</accession>
    <name>A0A182PP56_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dehydrogenase/reductase SDR family protein 7-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP56"/>
    <dbReference type="STRING" id="199890.A0A182PP56"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008735-RA">
        <property type="protein sequence ID" value="AEPI008735-PA"/>
        <property type="gene ID" value="AEPI008735"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008735"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05332">
        <property type="entry name" value="11beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004825">
        <property type="entry name" value="PRK06181.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008735-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34264" checksum="56915FF4E583284E" modified="2016-09-07" version="1">MKNLAERSAGSLYWWLLATLFLPIAIPGLVLKLLTMMKEQRNARNLNGKVVLITGASSGLGEALAHSFFLAGCKVVLAARRKDELERVRKDLLELHATVPTHPPIILPLDLSDLNSMAAKVQTVLEIHGAIDILVNNGGISVRGDALSTAIDVDIRIMLVNYFGTVALTKACLPSMMARKEGRIVSISSVQGKFAIPHRSAYSASKHALQAFCDSLRAEVAKDNIKVTLISPGYINTALSLNALTGSGASYGKMDATTAGGASPEDTARSILKAIVRDEKDIVLAPIAPRAAYWLRHLIPPVYFWIMKKRAEKLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPF6</accession>
    <name>A0A182PPF6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPF6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008835-RA">
        <property type="protein sequence ID" value="AEPI008835-PA"/>
        <property type="gene ID" value="AEPI008835"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008835"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131756" evidence="2">
        <location>
            <begin position="28"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
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        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
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        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008835-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="907" mass="103511" checksum="293D273D09866BB7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPH5</accession>
    <name>A0A182PPH5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPH5"/>
    <dbReference type="STRING" id="199890.A0A182PPH5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008854-RA">
        <property type="protein sequence ID" value="AEPI008854-PA"/>
        <property type="gene ID" value="AEPI008854"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008854"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
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        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008854-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="289" mass="31360" checksum="3FBD290270E99E5E" modified="2016-09-07" version="1">MVGPNGAQQTSATSFLQLSQDHLTAGQQQQTGPAVHQPGMKLFPNYTPPIPPHHQHHQHHNGNSGLVGDDGGSNPASNHHYHQITYQTQTLAPLRLNQDHFLPSTHAAKTNTGVNQARSHAKYQTHHHHQVHHHHGVVGDASTLHHHGSSYSPDAQLHHHHHHHHHPHAHHHPHHLRDDGSDREDEDTLDVNDGEGSGQSDATSPPQSPLSPVPPELPIRNGLLANTLNHINNNSSVSSNGPIMVTDRIRSPPSPPVTPPPATHTTGSSTTLGNGGGRKTLSVARQHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPJ3</accession>
    <name>A0A182PPJ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPJ3"/>
    <dbReference type="STRING" id="199890.A0A182PPJ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008872-RA">
        <property type="protein sequence ID" value="AEPI008872-PA"/>
        <property type="gene ID" value="AEPI008872"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008872"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053202">
        <property type="entry name" value="EGF_Rcpt_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009:SF2">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="90"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008872-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="466" mass="52482" checksum="AA846A99F20C0B7C" modified="2016-09-07" version="1">MSRDYDLMGVPQDNPALVKYVRDIHMKKYPMTFMRNANAPVEPLNFTNRHELTPEMAHLISDLLGRKRFGTFFQSLTGNSDSMMTAPWLAETMNWGGYLVEPDPRKYFSLRKQNAFRSNVQVIHACLSPNTYPKEVTLHHDDDSEVQINSVLDEETEWFHPRVKCFPVYTLMLAVNRTSIDLLSLGCHGQELQILQTIPFDRVHIKIISIHLVHYYEEDEMIIDVDEYVQSIGRFLMSKSYKLVRSMDRNFIYQHISVLSANKQRQRLQQQQQTFSMSDHMLQSVQQQQQPQPARGNAISSGEKPDATMEIRKGQDVSSNNSGSGGKMPISLALPTSTSTTTTAAATTTKSTTAAPSPSTAEPFSSERFDKLMLLRGGDSEPFDASDSEFIESSDSSALEDVSDSDTDDHGVEAYQQQETKQQQPDLVDLEQTVMVQQPVEEPEIEEGSVRVAGSSSPPPMVTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQB6</accession>
    <name>A0A182PQB6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Myosin N-terminal SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQB6"/>
    <dbReference type="STRING" id="199890.A0A182PQB6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009146-RA">
        <property type="protein sequence ID" value="AEPI009146-PA"/>
        <property type="gene ID" value="AEPI009146"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009146"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003012">
        <property type="term" value="P:muscle system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="10">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009146-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13484" checksum="14489CC4D70768F6" modified="2016-09-07" version="1">MAEDLRDRNDPELKYLSVERNSFNDPATQAEWTQKRLVWVPHESQGFVAASIKGERGDEVEVELAETGKRIVVLKDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRR7</accession>
    <name>A0A182PRR7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRR7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009652-RA">
        <property type="protein sequence ID" value="AEPI009652-PA"/>
        <property type="gene ID" value="AEPI009652"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009652"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009652-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="156" mass="16845" checksum="BE018ABF09FE28D5" modified="2016-09-07" version="1">MAGPIDTRKRSREEEQNEFMPLSKRINNLHLNNNQNSIAGGVLAEQIATGQPHDHHLLGAAGSCGMNIHSNHHHLIGVMAGTSSSSSNSSNSNGSSNASFQIPSNSGSNSPASSISINGEILGDYCPVLSAEENPHYFTKNKILYELYIERMSRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS29</accession>
    <name>A0A182PS29_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BEACH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PS29"/>
    <dbReference type="STRING" id="199890.A0A182PS29"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009764-RA">
        <property type="protein sequence ID" value="AEPI009764-PA"/>
        <property type="gene ID" value="AEPI009764"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009764"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="74"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="184"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="626"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="709"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009764-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="98935" checksum="FCBF4141D98DAACF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSI5</accession>
    <name>A0A182PSI5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocon-associated protein subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Signal sequence receptor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAP-alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSI5"/>
    <dbReference type="STRING" id="199890.A0A182PSI5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009920-RA">
        <property type="protein sequence ID" value="AEPI009920-PA"/>
        <property type="gene ID" value="AEPI009920"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009920"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131895" description="Translocon-associated protein subunit alpha" evidence="14">
        <location>
            <begin position="19"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009920-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="286" mass="31664" checksum="03B09152CA83F988" modified="2016-09-07" version="1">MQKFFVLLLLALPAVLLTVNTGSSPFAFAAEDELDEELVDVETEDAAVVADETEPEDEPETTKSPDADTYLLFTRPLHAAGSQLELPAGYPVEFLVGFTNKGEFEDFVVESVEASFRYAMDFSYFIQNFSAVPYNREVKPGHEATVSYSFLPTESFAGRPFGLNIALNYRDGRGNQFSEAVFNETVQITEVDEGLDGETFFLYVFLAAIVILLLVLGQQFLGSYGKRKRPTAARKVVETGTTSTKDVDYEWIPSETLKQLQNSPKGAPKSSPKQSPRQRKAKAGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSQ1</accession>
    <name>A0A182PSQ1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSQ1"/>
    <dbReference type="STRING" id="199890.A0A182PSQ1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009987-RA">
        <property type="protein sequence ID" value="AEPI009987-PA"/>
        <property type="gene ID" value="AEPI009987"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009987"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF187">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009987-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="263" mass="29769" checksum="4840A246D2D747FF" modified="2016-09-07" version="1">YGRWVTRRVAIGTIAVIWLLAALVSFVPISLDLHRDKRDKTDTSLKINGIKYETCALDLTPTYAVVSSCISFYVPCIVMIGIYCRLYCYAQKHVKSIRAVTRPGEISEKRYRSIRRPKSSKNKLKLRQLAHHASSPYHVSDHKAAITVGVIMGVFLICWVPFFCVNIIAAFCKTCIGQQTFKVLSWLGYSNSAFNPIIYSIFNTEFREAFKRILTSRSSWCCGQEMGNIYPRSSDRYVTDYAAKNVVMNSGRSSADLEQVSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTH2</accession>
    <name>A0A182PTH2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTH2"/>
    <dbReference type="STRING" id="199890.A0A182PTH2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010258-RA">
        <property type="protein sequence ID" value="AEPI010258-PA"/>
        <property type="gene ID" value="AEPI010258"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010258"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010258-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="581" mass="65285" checksum="7DDC69AF05CADB41" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTY8</accession>
    <name>A0A182PTY8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTY8"/>
    <dbReference type="STRING" id="199890.A0A182PTY8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010424-RA">
        <property type="protein sequence ID" value="AEPI010424-PA"/>
        <property type="gene ID" value="AEPI010424"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010424"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03165">
        <property type="entry name" value="NET-5_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF527">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010424-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="356" mass="39567" checksum="19CB39AD7EE46CFA" modified="2016-09-07" version="1">MGSGGRMDCCGQCVKYSMFVANFVIFLGGAIVFGLGIWTLVDKHFINELLGTNLFSGAVYVLIATSALVCLLSFFGCMGAAKEYKCMLLTYFILVFLIFVTMLIGGILGYVFREKVSQTMGDEMRSSMSLYGSRRSITTAWDETQERLKCCGVKSYSDWRGDIPQSCCQRTLDGYKPCIENPSPENIYINGCLEITSSYIRDNAAIIGGAGIGYFLLSFLTVVVLGVGSVLGYAFRERIALGLQDQMYESLDMYGRRRLTTVSWDMTQEDLQCCGVEDFRDWSERIPDSCCMDDYGARKRPCQQLQTSLTIHRQGCYEAITDALMRNGLLLGGSSLLLLVAIVPATVMAYYMLTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU82</accession>
    <name>A0A182PU82_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 6 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.267" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PU82"/>
    <dbReference type="STRING" id="199890.A0A182PU82"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010518-RA">
        <property type="protein sequence ID" value="AEPI010518-PA"/>
        <property type="gene ID" value="AEPI010518"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010518"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010518-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="416" mass="47021" checksum="E605AC27D556E28F" modified="2016-09-07" version="1">MSGYTEEYIRQKLTEKLEATHVCTVVRIGYGHLTESGKMDGKFSLLLVAIVAAGLFLRAAISLHSYSGQNRPPMYGDYEAQRHWQEVTVNLPVGDWYRNTTDNDLLYWGLDYPPLTAYHSYLVGLWARRWHNESYVALHKSRGISTEEHKQFMRNSVLLLDVLLYIPALLYATYTIRKRFADNRTAGAEWAYLTLAVLFPGQILIDNGHFQYNNASLGLCALAVVALVKGRTLVGAALFCLALNYKQMELYHALPFFFYLLRDCFIQTDKSSSALERLMAGTKKLVVLGLTVLATFIILWLPWLSSLDAVGQLVHRIFPVARGVFEDKVSNVWCVVNVFIKLRNIPNTTMALEVVDESDGCGGKFRVVVVSSQFQGKPLLQRHRLVNAALEEELKTIHAFSQKTYTPEQWAGESGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUK5</accession>
    <name>A0A182PUK5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PUK5"/>
    <dbReference type="STRING" id="199890.A0A182PUK5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010642-RA">
        <property type="protein sequence ID" value="AEPI010642-PA"/>
        <property type="gene ID" value="AEPI010642"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010642"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000150">
        <property type="entry name" value="ATP7, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000031">
        <property type="entry name" value="Probable copper-transporting ATPase HMA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="672"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="717"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1121"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1149"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="125"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="240"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="316"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010642-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1268" mass="136896" checksum="A444783AC3F0D1D7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUP1</accession>
    <name>A0A182PUP1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bardet-Biedl syndrome 2 protein homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUP1"/>
    <dbReference type="STRING" id="199890.A0A182PUP1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010678-RA">
        <property type="protein sequence ID" value="AEPI010678-PA"/>
        <property type="gene ID" value="AEPI010678"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010678"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016616">
        <property type="entry name" value="Bardet-Biedl_syndrome_2_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029333">
        <property type="entry name" value="BBS2_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055380">
        <property type="entry name" value="BBS2_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029429">
        <property type="entry name" value="BBS2_Mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029430">
        <property type="entry name" value="BBS2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055379">
        <property type="entry name" value="BBS2_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BBS2_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23353">
        <property type="entry name" value="BBS2_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14783">
        <property type="entry name" value="BBS2_Mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14781">
        <property type="entry name" value="BBS2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23350">
        <property type="entry name" value="BBS2_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013684">
        <property type="entry name" value="BBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4 7" id="KW-0969">Cilium</keyword>
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    <keyword evidence="5 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 middle region" evidence="10">
        <location>
            <begin position="167"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 GAE" evidence="9">
        <location>
            <begin position="401"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 platform" evidence="11">
        <location>
            <begin position="513"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 hairpin" evidence="12">
        <location>
            <begin position="611"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR013684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010678-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="742" mass="83585" checksum="0B0603E9D4643309" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV23</accession>
    <name>A0A182PV23_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PV23"/>
    <dbReference type="STRING" id="199890.A0A182PV23"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010810-RA">
        <property type="protein sequence ID" value="AEPI010810-PA"/>
        <property type="gene ID" value="AEPI010810"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010810"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010810-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="92" mass="9459" checksum="1AE69B44F8460ACF" modified="2016-09-07" version="1">MELCQQGSHGGTLSLAAIMSTAKRLVLSLRGRKESHGTAGTSSTRLVSANSTSPGHELDEIAVVSVGAESGHVSYGSLSLGHTNGPRYIPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV64</accession>
    <name>A0A182PV64_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PV64"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010851-RA">
        <property type="protein sequence ID" value="AEPI010851-PA"/>
        <property type="gene ID" value="AEPI010851"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010851"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17313">
        <property type="entry name" value="MFS_SLC45_SUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010851-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="74534" checksum="FFC9BC07B439C419" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWL7</accession>
    <name>A0A182PWL7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWL7"/>
    <dbReference type="STRING" id="199890.A0A182PWL7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011354-RA">
        <property type="protein sequence ID" value="AEPI011354-PA"/>
        <property type="gene ID" value="AEPI011354"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011354"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="169"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011354-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="274" mass="31570" checksum="D89B3DF3C71153B5" modified="2016-09-07" version="1">PPLTSSELQLSELRLCHLAQQDSFSEDRHQITNGRELSRSSMLKWLSPFIDETGIKRVGGRLHNAQLPDCTKHPILLSSKHQLAALITEAYHQKYLHAGPELLLSILRQRFWIIAEVELCMNSRPLIPLSSDPSDTEPLTPGHFLVGSNMLSLPQVDRSQIPTNRLKELELVQKHLQSIWSRWYPEYLQQLQARAKHSMAQPVQLEEGQLAIIKEDNVPPTLWPMGRITKLHPGKDGIRQENKLFETQRELRFSLTHYVQRVKVQIRLLRGSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWN0</accession>
    <name>A0A182PWN0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWN0"/>
    <dbReference type="STRING" id="199890.A0A182PWN0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011367-RA">
        <property type="protein sequence ID" value="AEPI011367-PA"/>
        <property type="gene ID" value="AEPI011367"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011367"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011367-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="76" mass="9107" checksum="F71F1636CDCA51E2" modified="2016-09-07" version="1">PRTILRTQRNPPIPRDLGNGKFWYHGIRRCLTVELRKHKILPRNLLFDINIDGLPLHNRAKTQFWPILLRVVDQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWS9</accession>
    <name>A0A182PWS9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182PWS9"/>
    <dbReference type="STRING" id="199890.A0A182PWS9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011416-RA">
        <property type="protein sequence ID" value="AEPI011416-PA"/>
        <property type="gene ID" value="AEPI011416"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011416"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF12">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011416-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="183" mass="21737" checksum="32A93A7536C112F2" modified="2016-09-07" version="1">MSSTNISESIPFYDVFGYYEWTLTLADPRTKGWPMVDSPIPTLTGVCIYLFLVWIGPKIMRDRKPFDLTTFLVPYNLAMALLNLYICLQLFIGSTMRRYSYICEPCRQSFHPAELRIVDAVWWYYFSKVLEFSDTFFFILRKKDNQLTFLHVYHHSTMFSFWWIGVKWVPSGSSKCTFYLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX01</accession>
    <name>A0A182PX01_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX01"/>
    <dbReference type="STRING" id="199890.A0A182PX01"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011488-RA">
        <property type="protein sequence ID" value="AEPI011488-PA"/>
        <property type="gene ID" value="AEPI011488"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011488"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011488-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="117" mass="13535" checksum="699B4E256567B13A" modified="2016-09-07" version="1">MLTLQQPALSREWMCPILLEKENQASRLIESILQEELDNTIINFMRLSRTDFSYLLQQIAPNIQKADTNMRKSLSAKDKLIISAQAIDKFIPEVCCCIVEVLKDFVKSYLQLQTIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX65</accession>
    <name>A0A182PX65_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1758 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX65"/>
    <dbReference type="STRING" id="199890.A0A182PX65"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011552-RA">
        <property type="protein sequence ID" value="AEPI011552-PA"/>
        <property type="gene ID" value="AEPI011552"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011552"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011552-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="320" mass="36834" checksum="12973FC446A28C52" modified="2016-09-07" version="1">MKVAGAVVSTIRSLTTEYSTCLELLVLPKIATDLPSETIDVRDWAFPKRVRLADPQFNERSSIDLLIGVDTFMDIIKSRKIRLECGLPTLLETELGWIVSGACTNNKVKLSMACTIQRKEEESDIGSLMNAFFNIEEVIDQSVWSVEEQECEDYFQATKRRECDGRYIVRLPFKTDRELGRSKEIAMHRLKGLERRFEREPKLKEAYESFMREYFANEVVNLKEGKQVSRKSPLRALKPVMGKDNIMRVGGRLSNADITEEQKHPIIIPGKHRLAELIASKYHEILRHAAVQLTINTIQLKYWIIGSRNVVKRTIFNCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYW9</accession>
    <name>A0A182PYW9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYW9"/>
    <dbReference type="SMR" id="A0A182PYW9"/>
    <dbReference type="STRING" id="199890.A0A182PYW9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015037-RA">
        <property type="protein sequence ID" value="AEPI015037-PA"/>
        <property type="gene ID" value="AEPI015037"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015037"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015037-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="509" mass="58704" checksum="6FC5255DCC9DB701" modified="2016-09-07" version="1">MEPITVVLSAFIFIVSIVYLFVRSKHNFWKDQGVPYAPKPHFFYGHVKGQSRTRHGADINQELYKQFKQRGVPYGGISLFIMPSLIVVDPELVKTILVKDFNVFHDRGVYSNPRDDPFTGNLFGLEGTPWRLLRQKLTPTFTSGRMKQMFGTIWAVALELEKYMEENYNQPEIEMKDVLGRFTTDVIGTCAFGIECNTLKTPDSEFRKYGNKAFELDPVTMTKFFFATSYPKLARKLHVRTTQQDVEDFFMKIVRETVDYRESNNVQRNDFMNLLLQIKNKGKLDDHGTSVGKGEIGLTQNELAAQVLIFFLAGFETSSTTQSFCLYELAKNPDIQDRLRDEINRAIEENGGEVTYDLAMNIQYLDNVINETLRKYPPVETLTRKPSTDYVIPGTTHIVPKDTIVQIPIYAIQRDPDHYPDPERFDPDRFLPEEVKKRHPYVYLPFGEGPRICIGLRFGMMQTKVGLINLLRRFRFSPSARTPERVVFDPKMFTLSPIAGNYLKVEKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYY6</accession>
    <name>A0A182PYY6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYY6"/>
    <dbReference type="STRING" id="199890.A0A182PYY6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015054-RA">
        <property type="protein sequence ID" value="AEPI015054-PA"/>
        <property type="gene ID" value="AEPI015054"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015054"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF134">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015054-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="394" mass="46167" checksum="5C407AFF32B82DA7" modified="2016-09-07" version="1">MSSYYRRHARIFQVAALIYLVPCSYNPGTDKFEQRTLNKLAFAFAIASTVPFWYFDLKNMVAFYLENISPIMMAVGCIEIALYVSIVSFTLLGTFGRRNRYTRLMNVLFHTDWLLDRYERVEREYDNRRQFAALVFFVVAMVCFNLYYHRDANIRLLSISVALKIFGVCYLATVHRICVGAIGVRMRQLAALYDMGRGYRTQDLTVHCFIERFELYAAQVAQIDQCFSLPLTMVILLVVIEMVYLLFDLFTVFELGRPVLEETMQIDYTQWVLRQLWQMIYGAVVLLTVTGCQKTSGEILQTAQLVRHFDNDRPRRSRAANQVQRFLLQNVNRKTTFSVWNMFDIDYAMLHMVFSSIFTYMVILVQFDQMQPEYLSYTSVNSANITDTKVVHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ69</accession>
    <name>A0A182PZ69_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GST class-theta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PZ69"/>
    <dbReference type="STRING" id="199890.A0A182PZ69"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015134-RA">
        <property type="protein sequence ID" value="AEPI015134-PA"/>
        <property type="gene ID" value="AEPI015134"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015134"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000034">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="86"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015134-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="214" mass="24551" checksum="7588ED806AFED36D" modified="2016-09-07" version="1">MDFYYLPLSAPCQSIRLLAKALGVHLNLKELDLLKGEHMKPEFLKINPQHTIPTLVDNDFVLWESRAILTYLCEKYGKNDALYPKDPKKRAVVNQRLYFDMGTLYLRFSQAFYPVMMEGKELNPDNVLKLEEALEFLEHFLGKTPYAAGDRLTVADFALLASITTIQVTGGRDLSKYPNIQRWYNELKESVVGHQEICVEGATSFRETFSPIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PK77</accession>
    <name>A0A240PK77_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sepiapterin reductase</fullName>
            <ecNumber evidence="4">1.1.1.153</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sepiapterin reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.153" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A240PK77"/>
    <dbReference type="STRING" id="199890.A0A240PK77"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015257-RA">
        <property type="protein sequence ID" value="AEPI015257-PA"/>
        <property type="gene ID" value="AEPI015257"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015257"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004757">
        <property type="term" value="F:sepiapterin reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000259">
        <property type="entry name" value="Sepiapterin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051721">
        <property type="entry name" value="Biopterin_syn/organic_redct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006393">
        <property type="entry name" value="Sepiapterin_red"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01500">
        <property type="entry name" value="sepiapter_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44085">
        <property type="entry name" value="SEPIAPTERIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44085:SF2">
        <property type="entry name" value="SEPIAPTERIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015257-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="304" mass="33244" checksum="9C355EBA3D1244CA" modified="2017-10-25" version="1">MYVCVSLLASFDRLIHPTTHKALPIMSSATTTTTPTPATTTAVNLEQVAYFLVTGASRGIGAKMAIETARKFKPGSVVVLLARSASGLESTRAEILAVNPHVTVVTSSVDLATASKELLNEILEKSLGKQPTDRFGLACVIHNVGTVGNIERKAIDMDDRAEWEQYFGMNVFTVAVLNSCFLRKFQSVPVKLVVNITSKACLVPFQSMTYYCAGKAARELYFRVLAEEEATAGITVLNYSPGPVDTEMTVELQANSNASDIRDYFKNLRDTTTILTTDQTTAKFLHILQNGLFKSGDHVDYYDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZV6</accession>
    <name>A0A182NZV6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182NZV6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000187-RA">
        <property type="protein sequence ID" value="AEPI000187-PA"/>
        <property type="gene ID" value="AEPI000187"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000187"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098592">
        <property type="term" value="C:cytoplasmic side of apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035332">
        <property type="term" value="P:positive regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13185">
        <property type="entry name" value="FERM_C_FRMD1_FRMD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041781">
        <property type="entry name" value="FRMD6-FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047145">
        <property type="entry name" value="FRMD6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429">
        <property type="entry name" value="FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429:SF5">
        <property type="entry name" value="PROTEIN EXPANDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
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        </location>
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        </location>
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        </location>
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        <source>
            <dbReference type="PROSITE" id="PS50057"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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    </evidence>
    <sequence length="1472" mass="155321" checksum="1C1E5035B895B734" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0B0</accession>
    <name>A0A182P0B0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
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    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
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        <text evidence="5">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
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            <position position="1"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000342-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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    </evidence>
    <sequence length="269" mass="29854" checksum="C56FEF5D9244CBA0" modified="2016-09-07" version="1">MAVGKNKGVSKGGKKGSKKKVVDPFTRKDWYDVKAPNMFKNRQVGKTLVNRTQGTKIASDGLKGRVFEVSLADLQNEPDAERSFRKFKLVAETVNGRDVLTNFHGMDLTTDKLRSMVKKWQTLIECSVDVKTTDGFMLRVFCIGFTIKDSMSQRKTCYAQHSQIKNIRAKMTAIIKREITSTDLKGVVEKLLPDSIAKDIEKACQVVYPLHDVYIRKVKVLKKPRFDLASLMELHGDGGGKAAEVSTGAASGVVVDRPEGYEPPVQASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0E7</accession>
    <name>A0A182P0E7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBA domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P0E7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000379-RA">
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        <property type="gene ID" value="AEPI000379"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
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    </dbReference>
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        <property type="entry name" value="UBA-like_sf"/>
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        <property type="entry name" value="PROTEIN GAWKY"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13020">
        <property type="entry name" value="TRINUCLEOTIDE REPEAT-CONTAINING GENE 6"/>
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    </dbReference>
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        <property type="entry name" value="M_domain"/>
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        <property type="entry name" value="RRM"/>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="881"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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    </feature>
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        </location>
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        <location>
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        </location>
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        <location>
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        <location>
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        <location>
            <begin position="1371"/>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        <location>
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        </location>
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        </location>
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        <location>
            <begin position="1374"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        <location>
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            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1435"/>
            <end position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000379-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1651" mass="169694" checksum="C3C17014FBC113CB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0L5</accession>
    <name>A0A182P0L5_9DIPT</name>
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        <recommendedName>
            <fullName evidence="10">Rab5-interacting protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0L5"/>
    <dbReference type="STRING" id="199890.A0A182P0L5"/>
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        <property type="gene ID" value="AEPI000447"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000447"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RCAF1"/>
    </dbReference>
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        <property type="entry name" value="GEL COMPLEX SUBUNIT OPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="105"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000447-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15213" checksum="9C700E9EBB91F361" modified="2016-09-07" version="1">MVVKSSNSEKVAKSKQSHISSVWNRAIKPNSEWAEKDDFLDVVYWARQVLSILIGIVMGLIPLKGFIALALFALLNCGAVYLYSTSFQNIDEDAYGGMWEVVKEGFMTSFACFLVTWIIFYTGIHFDSVIIEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0W5</accession>
    <name>A0A182P0W5_9DIPT</name>
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        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P0W5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000547-RA">
        <property type="protein sequence ID" value="AEPI000547-PA"/>
        <property type="gene ID" value="AEPI000547"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000547"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061860">
        <property type="term" value="F:DNA clamp unloader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="831"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="84"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000547-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1407" mass="155565" checksum="67AC3360B3EA998D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P158</accession>
    <name>A0A182P158_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P158"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000640-RA">
        <property type="protein sequence ID" value="AEPI000640-PA"/>
        <property type="gene ID" value="AEPI000640"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000640"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000640-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="172" mass="18545" checksum="44A0E08BA33C466B" modified="2016-09-07" version="1">MDLRGDDLSDRGAVYFSDRDRSNHFGDWSNGLDDLVSLQGFTADDGVESVVLIGGVVNHTAVTVGVDQGVLSLNVISVALFLLALDVSGVVIMNGVLELVLGRGFWVLDVLYSLDQSWLDSLDKSGLDSLNNGWLVILLVLWLVMVRIVVLSAGNGQESNDGQELFLPINGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2E6</accession>
    <name>A0A182P2E6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPR158/179 extracellular domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2E6"/>
    <dbReference type="STRING" id="199890.A0A182P2E6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001080-RA">
        <property type="protein sequence ID" value="AEPI001080-PA"/>
        <property type="gene ID" value="AEPI001080"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001080"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18773">
        <property type="entry name" value="PDC1_HK_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF25">
        <property type="entry name" value="MIP05539P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130732" description="GPR158/179 extracellular domain-containing protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="776"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="GPR158/179 extracellular" evidence="11">
        <location>
            <begin position="263"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="GPR158/179 extracellular" evidence="11">
        <location>
            <begin position="642"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001080-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="805" mass="94158" checksum="6FCF0FE22753A186" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2G0</accession>
    <name>A0A182P2G0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L35</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2G0"/>
    <dbReference type="STRING" id="199890.A0A182P2G0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001094-RA">
        <property type="protein sequence ID" value="AEPI001094-PA"/>
        <property type="gene ID" value="AEPI001094"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001094"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_uL29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001094-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="123" mass="14536" checksum="AE47606B0B91ED86" modified="2016-09-07" version="1">MVKVKCSELRQKDKKELTKQLEDLKKELLNLRVAKVTGGAPSKLSKIRVVRKAIARVYIVMNTKTKENLRKLYKGKKYVPLDLRPKKTRAMRKALSYRDAHRMTLKQQRRLAKFPRRRYAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P364</accession>
    <name>A0A182P364_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P364"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001348-RA">
        <property type="protein sequence ID" value="AEPI001348-PA"/>
        <property type="gene ID" value="AEPI001348"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001348"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="55"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="492"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="960"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001348-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1365" mass="155559" checksum="922094BA34C5FF2F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P374</accession>
    <name>A0A182P374_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P374"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001358-RA">
        <property type="protein sequence ID" value="AEPI001358-PA"/>
        <property type="gene ID" value="AEPI001358"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001358"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001358-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="60" mass="7305" checksum="13EDE5528A257687" modified="2016-09-07" version="1">MYVTTYDRIILLQDYARSLMAAPVCTYLQTIKWDPRYGLDISSFYHLFRLMEHRLTTKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3F1</accession>
    <name>A0A182P3F1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3F1"/>
    <dbReference type="STRING" id="199890.A0A182P3F1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001436-RA">
        <property type="protein sequence ID" value="AEPI001436-PA"/>
        <property type="gene ID" value="AEPI001436"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001436"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001436-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="400" mass="46378" checksum="B81BD4DFE5E1746F" modified="2016-09-07" version="1">MDSSTKKSEYLLIPLTIKLLKMIRFWNESPGQRISTFGVFVVVSYPIVWLIPSWLFILSSQDDVKRLMKAVNEQIVFLIVFFKLFFYAVHYRRLEQLFYDVQRAFSTVMNDPSIEIQKILGHVTKSTHNLTKYYCSALSFNCAAYGLFPMLFIVIKYAMTGSYAEPLPTPIEANYFIPDYHTNLWMWLPLDLTLNLILTLDGLSLFLLECFTWNLVYVTSRMFQVLKIQSDELLNRRLGEEEWAMALKRIITLHDSVLRSAFTLEEILSGQLLLLYISTIFALCLGMVVLSLAFEEVYLLLTTSAVLGYCIFQTFSFSYLGTELIEQSSAVSDAIFHSAWYTQDVKRQKDLCFVLLRANKPVRLTAAKFFVVTRDSFTQVIKQAYTIFTLMSQFLNDRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3V4</accession>
    <name>A0A182P3V4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium-bile acid cotransporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3V4"/>
    <dbReference type="STRING" id="199890.A0A182P3V4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001590-RA">
        <property type="protein sequence ID" value="AEPI001590-PA"/>
        <property type="gene ID" value="AEPI001590"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001590"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130778" description="Sodium-bile acid cotransporter" evidence="8">
        <location>
            <begin position="26"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001590-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51135" checksum="5220FAA21D836533" modified="2016-09-07" version="1">MACPLHKLLLFTALLILQLIATCKATIMDNHEERDSVHRQVSNVGWEVTYDPPNLNMDMSTTRNVTLRIDRITKADLEDIQSVQFKSEREHVAWVENGTIVLEPLVASIAYNGSFSVVANFLGQTNFFVELVRKNGSSETIKSSTLPVTVIRPERVIDHVFTVSVILLISILYINFGAALDVGALKQIALRPVGPVIGFVCQFVFMPLLSYGLGHLLFPDNYELQLGLFFTGVSPAGGASNIWTVALGGNLTLSIAMTTISTIAAFGMMPLWIFTLGRTIFQKANLVVPYSRIAYTAVGLVVPISAGLLIQRYCPRFSRLLVRILKPMSVILILFIVIFAIVTNLYLFELFSWQIIIAGLGLPLLGYCFGFLVSFLLRLPFADSLAISVETGIQNTGIAIFLLRFALEQPAADLTTVMPVSNAIMTPLPLLLLLVGLRLHERSKRRAENSLIPKTETDPVIATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P433</accession>
    <name>A0A182P433_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 H2O = 2 alpha-D-mannopyranose + an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:56052"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28729"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="3.2.1.114"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A182P433"/>
    <dbReference type="STRING" id="199890.A0A182P433"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001669-RA">
        <property type="protein sequence ID" value="AEPI001669-PA"/>
        <property type="gene ID" value="AEPI001669"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001669"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004572">
        <property type="term" value="F:mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10809">
        <property type="entry name" value="GH38N_AMII_GMII_SfManIII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000001">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000042">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000009">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000007">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF70">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="11">
        <location>
            <begin position="499"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1138"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1138"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1158"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001669-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1231" mass="139865" checksum="75233E183459B47F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P444</accession>
    <name>A0A182P444_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mpv17-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P444"/>
    <dbReference type="STRING" id="199890.A0A182P444"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001680-RA">
        <property type="protein sequence ID" value="AEPI001680-PA"/>
        <property type="gene ID" value="AEPI001680"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001680"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF26">
        <property type="entry name" value="IP08061P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001680-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21851" checksum="34E5763CF32EE36A" modified="2016-09-07" version="1">MWWKFIVEVTNEYKILRGMISYSALWPIGCLIQQTFEGKRFKNYDWERCLRYSLYGTFVSAPMLYTWMRCANIMWPRTDFRSSLAKAFTEQAAYDPFAIVLFFYGMSILERRTQQQAGDEVQSKFWDTYKVGFFYWPMVQTFNFSLVKPKNQIVIAGFFSLIWTTFLAYVKTSQKEKPIAETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4J5</accession>
    <name>A0A182P4J5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM122 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4J5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001831-RA">
        <property type="protein sequence ID" value="AEPI001831-PA"/>
        <property type="gene ID" value="AEPI001831"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001831"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026716">
        <property type="entry name" value="PBIR1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227:SF6">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001831-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="539" mass="55555" checksum="AAC44EA433402AF1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4R6</accession>
    <name>A0A182P4R6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4R6"/>
    <dbReference type="STRING" id="199890.A0A182P4R6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001902-RA">
        <property type="protein sequence ID" value="AEPI001902-PA"/>
        <property type="gene ID" value="AEPI001902"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001902"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060076">
        <property type="term" value="C:excitatory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098700">
        <property type="term" value="P:neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050803">
        <property type="term" value="P:regulation of synapse structure or activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17382">
        <property type="entry name" value="MFS_SLC17A6_7_8_VGluT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000226">
        <property type="entry name" value="Vesicular GLUtamate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000264">
        <property type="entry name" value="vesicular glutamate transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF456">
        <property type="entry name" value="VESICULAR GLUTAMATE TRANSPORTER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="68"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001902-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="583" mass="63960" checksum="62745198481898AE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P586</accession>
    <name>A0A182P586_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P586"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002074-RA">
        <property type="protein sequence ID" value="AEPI002074-PA"/>
        <property type="gene ID" value="AEPI002074"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002074"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130844" evidence="2">
        <location>
            <begin position="20"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002074-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="298" mass="33098" checksum="570C17FE292EF09E" modified="2016-09-07" version="1">MLLAVGLLLSLIRAPKGSSEMISVKLFNQYHARTFDVPGQLDANEQDLDADRPLPAGHEDIDAVNRLDGIGNDLAIEYVHPPTAIEPIDVIDRKENGIEQDLVVSVPMPDQRLLDGWMQPRTPESNAMPADGAKPNAVTTTTTTTSTTTRTTTVRKIHRKARLMPRSIRQEEAAPAPCGCQHKKRSLGNHLYSSEEMGDPAGDYDEYDDYDYGAGELRLPPVVTSRPMLLPAMSRLLATPVSGEALESSVERAEKVHGTLERLMGIVTIFSHVDEFIQRKTKQSIRRLARLYESEELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5H9</accession>
    <name>A0A182P5H9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADAM10 endopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.81</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endopeptidase of broad specificity.</text>
            <dbReference type="EC" id="3.4.24.81"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.81" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182P5H9"/>
    <dbReference type="STRING" id="199890.A0A182P5H9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002169-RA">
        <property type="protein sequence ID" value="AEPI002169-PA"/>
        <property type="gene ID" value="AEPI002169"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002169"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049038">
        <property type="entry name" value="ADAM10_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21299">
        <property type="entry name" value="ADAM10_Cys-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="8">
        <location>
            <begin position="316"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="7">
        <location>
            <begin position="582"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="872"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="926"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002169-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113069" checksum="E4DB7978A3398ECF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6J3</accession>
    <name>A0A182P6J3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of split malpha protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6J3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002541-RA">
        <property type="protein sequence ID" value="AEPI002541-PA"/>
        <property type="gene ID" value="AEPI002541"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002541"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029686">
        <property type="entry name" value="Malpha/m4/m2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12254:SF0">
        <property type="entry name" value="BARBU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12254">
        <property type="entry name" value="ENHANCER OF SPLIT MALPHA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15952">
        <property type="entry name" value="ESM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002541-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20478" checksum="30C284A1878B79C4" modified="2016-09-07" version="1">MHSYAVNNAANLAACSNNSINENRYNSEKLAKSSAVYRLKKILKPLVTLLKSKSKAQSVKSTAAAAQVDQRRSIISYIDDFDCDYDNSANERLEAELVAELEQCHATDAAILVLEDQQLRLQPVLPEELYVPVHFARTEAGTFFWTAMPAREVDEDLIQPALCYSEEKQYAQQAYADRWAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6Y8</accession>
    <name>A0A182P6Y8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM129 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6Y8"/>
    <dbReference type="STRING" id="199890.A0A182P6Y8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002688-RA">
        <property type="protein sequence ID" value="AEPI002688-PA"/>
        <property type="gene ID" value="AEPI002688"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002688"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018801">
        <property type="entry name" value="TM129"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31322">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TM129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31322:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TM129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10272">
        <property type="entry name" value="Tmpp129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002688-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="394" mass="44763" checksum="9D3F2B14FCE2D6EF" modified="2016-09-07" version="1">MVPHIIYGIIFVMLFFFTIFPTAEMESAGLTVNHLCSHYLSAEMDFVLYQLKATSVKLLIHSSLPFIYVIFIWLMAWINPDEMMMHSHASPLGESLWSAFCSGAGTLLIVAMVTVLYWAQDGWSNHPIAKQLHLLTNPALPDWRSVATNINDEYRRDTKVLIRSSAISTLVVTESWIIKTNMYVHNIIPQSQALLCAYKIDTKEVITDTLESAEFVNIGVKPQLTGRVKPFIIRINIAHIKELQDRLQQPILVMPSVQFRTLTERFVEAFMEEVAQNPTAPPSTHVPDEGDCCLACLQAQPDVKIVKYCFDVDVTGAVLPESERCQPCGCRPLWCVGCLATWFASQQQRAERDTWLSKKTTCPMCRARFCVRDVCYLENRVVQQPEPVQQQTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P878</accession>
    <name>A0A182P878_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="STRING" id="199890.A0A182P878"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003131-RA">
        <property type="protein sequence ID" value="AEPI003131-PA"/>
        <property type="gene ID" value="AEPI003131"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003131"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06608">
        <property type="entry name" value="STKc_myosinIII_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000259">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000003">
        <property type="entry name" value="TRAF2 and NCK-interacting protein kinase isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051700">
        <property type="entry name" value="STE20_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096:SF1">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="8">
        <location>
            <begin position="1228"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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    <sequence length="1545" mass="169056" checksum="9C21BE039415A5D5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P887</accession>
    <name>A0A182P887_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
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    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the integrin beta chain family.</text>
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    <keyword evidence="5" id="KW-0732">Signal</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR002512-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003140-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="779" mass="88404" checksum="4D50523E7339B6C8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8A2</accession>
    <name>A0A182P8A2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8A2"/>
    <dbReference type="STRING" id="199890.A0A182P8A2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003155-RA">
        <property type="protein sequence ID" value="AEPI003155-PA"/>
        <property type="gene ID" value="AEPI003155"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003155"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF33">
        <property type="entry name" value="AT22075P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="6"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003155-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="464" mass="50301" checksum="9335E7F47C0FC42A" modified="2016-09-07" version="1">MHLLTVTITTFVAANIISLSLGTAIGWLSPFLPLLISSDSPLDAGPVTDIQATWIASLLCIGAFGGTFLFGWSAEKFGRKTSLLATAVPLICFWGCVAFGTTVEVLYVARLLAGLGAAGVFLLVPMYITEIAEDRIRGTLGSLFILFLNIGTLVSFVMGSYLSYHMTAYILFALPIVFLALFLQFPETPQYLIRRNRVRDAESSLKYLRGYTSTPDHLEMLRSEMDGLLVQVSGEKDSTEQSSISLADFAPPSARKALLIGLVLVSLNQLSGCFALINYTAQIFADSGSDLDPNMAAIVVGAIQIIGSYGSTIIVDRCQRKHVYIVTSFFAAIGLFAMGTHGYLKSQHVDVSAINWIPVASLSFVIFIASVGLLPLTFVILSEILPPKVRGLGGSLCTAFLWTISFLVVKYFPVMVELIGLHGCMWVFCAVCLSAGLFNAIFIPETRGRSIEQIIHAMENNIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8A7</accession>
    <name>A0A182P8A7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Membrane protein BRI3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Brain protein I3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with BRI3BP. Interacts with MGAT1 and IFITM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRI3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8A7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003160-RA">
        <property type="protein sequence ID" value="AEPI003160-PA"/>
        <property type="gene ID" value="AEPI003160"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003160"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019317">
        <property type="entry name" value="BRI3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13551">
        <property type="entry name" value="BRAIN PROTEIN I3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13551:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN BRI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10164">
        <property type="entry name" value="BRI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003160-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="161" mass="17090" checksum="963C945EA130B28A" modified="2016-09-07" version="1">MASQKFSNEPPSYEQVIADSNQQSYVYGGAQPSAPSVATAATSIPSAAASYPRQEYTQQQPTAHTYVTPAAGTVPYYGAMDGNKGTAVPIVPQVTIQTVQPPAVISQQIIVVNGCPACRIGMLEDDYSCLGIFCAIFFFPIGILACLALRNRRCTNCGAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8P0</accession>
    <name>A0A182P8P0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Rad4 beta-hairpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8P0"/>
    <dbReference type="STRING" id="199890.A0A182P8P0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003293-RA">
        <property type="protein sequence ID" value="AEPI003293-PA"/>
        <property type="gene ID" value="AEPI003293"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003293"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DNA repair protein complementing XP-C cells"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BHD_2"/>
    </dbReference>
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        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018026">
        <property type="entry name" value="DNA_repair_Rad4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00605">
        <property type="entry name" value="rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="798"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="10">
        <location>
            <begin position="853"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="11">
        <location>
            <begin position="916"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="11">
        <location>
            <begin position="989"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="641"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003293-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1151" mass="129384" checksum="EDEDC28EF3D1A565" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8Q4</accession>
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    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
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                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of translation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="eIF4E-T"/>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER"/>
        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="77"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="178"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="351"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003308-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8R0</accession>
    <name>A0A182P8R0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P8R0"/>
    <dbReference type="STRING" id="199890.A0A182P8R0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003314-RA">
        <property type="protein sequence ID" value="AEPI003314-PA"/>
        <property type="gene ID" value="AEPI003314"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003314"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070876">
        <property type="term" value="C:SOSS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000072">
        <property type="entry name" value="SOSS complex subunit B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003314-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="25595" checksum="475C318B0E01F962" modified="2016-09-07" version="1">MAVNMYGPMQNHPPPNPNPTDLMAIKDIYPGMKNINVIFIILEIGPVTLTKENREVRTFKVADQSAAINVSIWDEPGKQLSPGDIVRLTKGYANVWRQSLTLYSGKNGEIVRLGDFCYTFNEMHNMSEPNPNLSASLPQPVLNNGSGGGPNSGPNSNNGTGKSMGSQPKPVPNSSNNSAMLSANSGPQPKPHAATTRYSVAVAAAAAAATSPSIMKPAQKNTPRTGRNSQAKGTAVKGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8T2</accession>
    <name>A0A182P8T2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Down syndrome cell adhesion molecule</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8T2"/>
    <dbReference type="STRING" id="199890.A0A182P8T2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003336-RA">
        <property type="protein sequence ID" value="AEPI003336-PA"/>
        <property type="gene ID" value="AEPI003336"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003336"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000093">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000967">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="77"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="171"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="260"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="362"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="491"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="601"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="702"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="788"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="892"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003336-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="985" mass="108565" checksum="4ACBE17633B10F79" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P993</accession>
    <name>A0A182P993_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P993"/>
    <dbReference type="STRING" id="199890.A0A182P993"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003497-RA">
        <property type="protein sequence ID" value="AEPI003497-PA"/>
        <property type="gene ID" value="AEPI003497"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003497"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1880:FF:000001">
        <property type="entry name" value="REST corepressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049048">
        <property type="entry name" value="REST_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF28">
        <property type="entry name" value="REST COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20878">
        <property type="entry name" value="REST_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="273"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003497-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="511" mass="54720" checksum="5F69546E924DA51E" modified="2016-09-07" version="1">MVRGKTKQLPDKSIASLVKFYYSWKKTRSRTSVMDRQEKMKKNDSSENGSDHGSNEESDNDDKPSSNSVAAAGTNSGSGGNSNPNISSSGSGGGNGKTNETENESNGSSGIGGATNEGSLNCAGCGVTCSEVHPSSHGKLCGSCHHHWRRTGVLRPTTGPSFMNKRTRGSNILGKSGDSHKRRPPKGMYINHDDIVKLASTAQNDDGAGGTVGSDGGGGRKGNQNNDLLASMDREIVSLLTQIQKNKQKSSGLKRKIDDMLEELNPPEVSSVRLNSRWNNEELMLAVQGVRMYGRDFQAIADALGTKTETQVRTFFINYRRRFNLDAVLKEFEATNAKKAPEIMSNNNNNNRANNSGTKESFDQSKANSSEMLIADTGKPIDSVTTGTGDVEDKDPENRPVEKDKPEKSVSPGGEFEIMEIDLVDDDNNRVAAATANGKSAKDAPDSVMIDSNNIIDDDTSINNLESVSVNSLSAAIALDSSLSMDVDEVTITPSIKNSDAVDASNTVIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAD4</accession>
    <name>A0A182PAD4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">CLIP domain-containing serine protease</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAD4"/>
    <dbReference type="STRING" id="199890.A0A182PAD4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003888-RA">
        <property type="protein sequence ID" value="AEPI003888-PA"/>
        <property type="gene ID" value="AEPI003888"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003888"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.30:FF:000001">
        <property type="entry name" value="Serine protease 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131046" description="CLIP domain-containing serine protease" evidence="15">
        <location>
            <begin position="26"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="17">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="16">
        <location>
            <begin position="122"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="17">
        <location>
            <begin position="226"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="16">
        <location>
            <begin position="482"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003888-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="73301" checksum="2AAFAA9CB3DDF6E8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAZ0</accession>
    <name>A0A182PAZ0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAZ0"/>
    <dbReference type="STRING" id="199890.A0A182PAZ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004095-RA">
        <property type="protein sequence ID" value="AEPI004095-PA"/>
        <property type="gene ID" value="AEPI004095"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004095"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000126">
        <property type="entry name" value="AGAP006185-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="83"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="465"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004095-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="65099" checksum="C9E6B22766083F07" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB01</accession>
    <name>A0A182PB01_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Extracellular metalloprotease that contributes to pathogenicity.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PB01"/>
    <dbReference type="STRING" id="199890.A0A182PB01"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004106-RA">
        <property type="protein sequence ID" value="AEPI004106-PA"/>
        <property type="gene ID" value="AEPI004106"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004106"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000165">
        <property type="entry name" value="Glucan 1,4-alpha-glucosidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF140">
        <property type="entry name" value="FI02848P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M14" evidence="18">
        <location>
            <begin position="94"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="18">
        <location>
            <begin position="486"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="18">
        <location>
            <begin position="803"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="17">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="17">
        <location>
            <position position="750"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="17">
        <location>
            <position position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004106-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1117" mass="126393" checksum="F26BA8004F1FB766" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBF1</accession>
    <name>A0A182PBF1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBF1"/>
    <dbReference type="STRING" id="199890.A0A182PBF1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004256-RA">
        <property type="protein sequence ID" value="AEPI004256-PA"/>
        <property type="gene ID" value="AEPI004256"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004256"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004256-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="150" mass="17123" checksum="6A195766FF2BBD81" modified="2016-09-07" version="1">MEYLTGLSQKENVDPQSHAVVPAQQRPGSESPEQNYLTPLQELRKQEEEEEKRKAEKAARKERKERARQAREARKEKKKRKHRKRSRSRSSSSSSDASSESSDSDSSSNDGKHKKKSRKRSKKKLTKKSKKSKKGKHSRKGKGSDSSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBP7</accession>
    <name>A0A182PBP7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBP7"/>
    <dbReference type="STRING" id="199890.A0A182PBP7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004352-RA">
        <property type="protein sequence ID" value="AEPI004352-PA"/>
        <property type="gene ID" value="AEPI004352"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004352"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004994">
        <property type="term" value="F:somatostatin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15094">
        <property type="entry name" value="7tmA_AstC_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000231">
        <property type="entry name" value="Allatostatin C receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000586">
        <property type="entry name" value="Somatstn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00246">
        <property type="entry name" value="SOMATOSTATNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131123" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="15">
        <location>
            <begin position="29"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="185"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="479"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
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        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
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        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004352-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="640" mass="68747" checksum="DC969F27D5E70658" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBR3</accession>
    <name>A0A182PBR3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vang-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the Vang family.</text>
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        <property type="gene ID" value="AEPI004368"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004368"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009539">
        <property type="entry name" value="VANGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20886">
        <property type="entry name" value="VANG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06638">
        <property type="entry name" value="Strabismus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007991">
        <property type="entry name" value="Strabismus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004368-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="588" mass="66270" checksum="D9F9E6529E702649" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBR8</accession>
    <name>A0A182PBR8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA polymerase theta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBR8"/>
    <dbReference type="STRING" id="199890.A0A182PBR8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004374-RA">
        <property type="protein sequence ID" value="AEPI004374-PA"/>
        <property type="gene ID" value="AEPI004374"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004374"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF12">
        <property type="entry name" value="HELICASE POLQ-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="344"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="570"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1109"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004374-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1139" mass="126548" checksum="492B4EC303EAC38C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCC3</accession>
    <name>A0A182PCC3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCC3"/>
    <dbReference type="STRING" id="199890.A0A182PCC3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004578-RA">
        <property type="protein sequence ID" value="AEPI004578-PA"/>
        <property type="gene ID" value="AEPI004578"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004578"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026193">
        <property type="entry name" value="NDUFV3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15880">
        <property type="entry name" value="NDUFV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004578-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="127" mass="13535" checksum="DCA496E6CCEBF9CF" modified="2016-09-07" version="1">MRLGMSGPSYARSIVKIKSPLTEMIRQILMKNDILVKLVAARGYSAAPSSTAGSKGPSAAAPAPAPPADVPGLSSRCVEKKDGPVGPGAERNGTYKVPEYFSYNQTSYFEAEIEMSKFRIPQPSAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCE2</accession>
    <name>A0A182PCE2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCE2"/>
    <dbReference type="STRING" id="199890.A0A182PCE2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004597-RA">
        <property type="protein sequence ID" value="AEPI004597-PA"/>
        <property type="gene ID" value="AEPI004597"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004597"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131120" evidence="3">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004597-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="139" mass="14776" checksum="208490F7DEC923E4" modified="2016-09-07" version="1">MKCFVAIALLAVAVSASPVEYGHYAAPALVHAPLAVHAPVVKHVVAEPVAYPKYSFNYGIKDPHTGDIKSQAEERDGDVVKGQYSLVEPDGSVRTVDYTADDHNGFNAVVHKSAPAVQKVIAAPVAHYAPAPVLSHYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCH8</accession>
    <name>A0A182PCH8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allatostatin CC</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCH8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004633-RA">
        <property type="protein sequence ID" value="AEPI004633-PA"/>
        <property type="gene ID" value="AEPI004633"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004633"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131244" description="Allatostatin CC" evidence="1">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004633-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21208" checksum="DA4747297D573F45" modified="2016-09-07" version="1">MRRILLQLTICCVLIETPSVWCKLASYKAIVPPAKIKSDETAKFAEVNYDDYPMVVPKRAAMLLDRLMVALHHALEKGDGENGSGRPINKVYRDGRYTGKPTVSLAPAKIPPPPPSKTEQLMKSYYAEADADEDAEDRVANSIPDDIDDMEARKELLDEMMDIQTRGTEDKSKKGRYWKCYFNAVSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDC9</accession>
    <name>A0A182PDC9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBM39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDC9"/>
    <dbReference type="STRING" id="199890.A0A182PDC9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004934-RA">
        <property type="protein sequence ID" value="AEPI004934-PA"/>
        <property type="gene ID" value="AEPI004934"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004934"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2140">
        <property type="entry name" value="Beta-1,3-glucan-recognition protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031756">
        <property type="entry name" value="BGBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043030">
        <property type="entry name" value="BGBP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15886">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51969">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM39" evidence="1">
        <location>
            <begin position="46"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004934-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="296" mass="32995" checksum="4E7B0D919A6C6CBE" modified="2016-09-07" version="1">MLAIDVILQQVCCHGHGRHNRGRYYQGHYEHHGHHGHHRHHRRPHHWIPPPNIDIYSPKGIEVSIPRWNGTSQYFAFEMFINNPDGGTPDVAHNTTELVYGKFIVRDTEVIIRQGDALNVTTYMGFTDGGVLKNTYSFHVFTRTTTTAATTTSTSSSTDWNRDQVIGGDYSDEDFDCVIDPTTNLCAYGSLIDERSGSRPQKLCVAEPRTNLLILDGVEDAYDPTVDWIGNVGAVLKQLPKLGKVAESGLVSAGRHGKVVVFQMDTLLTKLLVLYHAQEAGIKCVSDYDDVKIVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDS8</accession>
    <name>A0A182PDS8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ganglioside-induced differentiation-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDS8"/>
    <dbReference type="STRING" id="199890.A0A182PDS8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005083-RA">
        <property type="protein sequence ID" value="AEPI005083-PA"/>
        <property type="gene ID" value="AEPI005083"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005083"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44188">
        <property type="entry name" value="GDAP1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44188:SF1">
        <property type="entry name" value="GDAP1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="148"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005083-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="36139" checksum="BF2F7CE6F800E683" modified="2016-09-07" version="1">MSEKRFKRPSIANGDGLILYCNQYSYYCHKVLQALHEKEIRFTKYEIDVTNDEHFSEWFLELNPRAELPVLQNGLLIVPGSNRILDYLEENFPKNNPLRMPNETDKLVVGFRQTIESLPIGVITIGSFLHSQHTSSPKFPFVLPVRQTILARDETLSHRLRSYATEYPGFAEVLLKKADFHERKRTIIASEEYYCKLLIALDEFLTSVEQYLATIDIGRCWLVGTDTFTLVDISMGTLLHRLYVLGLEDRFWGKGKRPLVGRYFTKICQRESFQSVLPSKVSILRTVWINTPPVYKAGLAAVSSVLISSTLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDW8</accession>
    <name>A0A182PDW8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDW8"/>
    <dbReference type="STRING" id="199890.A0A182PDW8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005123-RA">
        <property type="protein sequence ID" value="AEPI005123-PA"/>
        <property type="gene ID" value="AEPI005123"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005123"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131142" description="VM domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005123-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="63718" checksum="A09753971B59B6CB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE44</accession>
    <name>A0A182PE44_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myb-binding protein 1A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PE44"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005199-RA">
        <property type="protein sequence ID" value="AEPI005199-PA"/>
        <property type="gene ID" value="AEPI005199"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005199"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="719"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1176"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="726"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1184"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1269"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005199-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1363" mass="153058" checksum="84C663702C234ABD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE71</accession>
    <name>A0A182PE71_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PE71"/>
    <dbReference type="STRING" id="199890.A0A182PE71"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005226-RA">
        <property type="protein sequence ID" value="AEPI005226-PA"/>
        <property type="gene ID" value="AEPI005226"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005226"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF209">
        <property type="entry name" value="CYTOCHROME P450-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005226-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="523" mass="60648" checksum="722F762B05318F29" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEJ2</accession>
    <name>A0A182PEJ2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEJ2"/>
    <dbReference type="STRING" id="199890.A0A182PEJ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005347-RA">
        <property type="protein sequence ID" value="AEPI005347-PA"/>
        <property type="gene ID" value="AEPI005347"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005347"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000044">
        <property type="entry name" value="GM25395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000140">
        <property type="entry name" value="Syntaxin 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="185"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005347-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="282" mass="31462" checksum="8CFF3BB2A6C528F0" modified="2016-09-07" version="1">MSREGLGLPRGIGQRDYGAMSSTATTSDGNFGGFSPTEFISLSESIAANTIFVKQSWQFLEKANRTIGTAKDNQSLRDKINDIQTGTNQRIGTTTKDLQRLTVVVRGGDKQQKLQVEKLTSDFKQVVEFYSKSQQSIAGKMKQVFLVNASQMDDLANDAGVPGTAEQQQELQKQRQLQQSLQFEQDMLLEREQRFREIEANVLDVNHIMKELSNITSQQSEVIDTIENSIGRTVDNVESGAEELVKAAEYQNRYRRKVLILLIIAVILGLVVTGIIVSKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEQ0</accession>
    <name>A0A182PEQ0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEQ0"/>
    <dbReference type="STRING" id="199890.A0A182PEQ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005405-RA">
        <property type="protein sequence ID" value="AEPI005405-PA"/>
        <property type="gene ID" value="AEPI005405"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005405"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005405-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="262" mass="30779" checksum="459C5934ABF719AF" modified="2016-09-07" version="1">MDAFPITSEDPDVRQRFAENIFQILRPLSALEMPRAHRPDDGDSSECSALSDPFSDLDESYILLDQRKKKPGVDESDELLLMNQFTPEFRCAYDELMGENRHRKQTKETPPEAAGCAACPDLQTATDFSPKFRSFIDEMLRKCDLQHHQEEKKRREQQQLLQQRKKGRVRTIVSEESFCGLETDSMSGMWRMLDAMSENERELFPTSGPHYDLYYDRRFDWMTRDEIPWEQIETSKKKCEQWLKIPSQLEQLNDGPKTKQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF20</accession>
    <name>A0A182PF20_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PF20"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005525-RA">
        <property type="protein sequence ID" value="AEPI005525-PA"/>
        <property type="gene ID" value="AEPI005525"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005525"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000008">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF58">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="910"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="949"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="990"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1024"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1095"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1135"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1166"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1191"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1219"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1257"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="670"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="746"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="776"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="804"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1370"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1370"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1388"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005525-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1458" mass="162541" checksum="C106EA33C3E07849" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF39</accession>
    <name>A0A182PF39_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fanconi_A_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PF39"/>
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        <property type="protein sequence ID" value="AEPI005544-PA"/>
        <property type="gene ID" value="AEPI005544"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005544"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031729">
        <property type="entry name" value="Fanconi_A_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15865">
        <property type="entry name" value="Fanconi_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fanconi anaemia group A protein N-terminal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005544-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="360" mass="40693" checksum="F88B2D3B5AA14382" modified="2016-09-07" version="1">MPDLPYEEEYRAQLKHLGYKEKELLKEAFQRQEWNMGSARVLSLLQEANILTASEYILSLDSIELIQQIMNDLLEAEYSLLAHIVRYAYQDTVQSQTLTTVLKDSFRSLLDDLNEDPNVIPCSYLQAIKERVLPSELKLIVHEHLQLVLLVQGDSPFDLDEAIGCQQRWRTEMQTTLNGTVFERLLGALVVDTASFIEVLKELLKKSCPFSLKYALYLVSLAAKAVALNSSGEKLLKSFVKDLFRTVVGTGLMSTMQLLLLFAREICAANATVLGAYPIWYKQTIGEMTYSVKKDQFISTMELLTALIPAERNLEMLGVHSTVAISAPAKCNDYVLNYKQLCRAHIAQLKEPDCTVVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF51</accession>
    <name>A0A182PF51_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
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        <property type="protein sequence ID" value="AEPI005556-PA"/>
        <property type="gene ID" value="AEPI005556"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005556"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055213">
        <property type="entry name" value="IML1_double_psi_beta_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23013">
        <property type="entry name" value="IML1_N"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="372"/>
        </location>
    </feature>
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        <location>
            <begin position="1264"/>
            <end position="1590"/>
        </location>
    </feature>
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            <end position="1102"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF19418"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005556-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1612" mass="182731" checksum="47170C375389B0E3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PG20</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="199890.A0A182PG20"/>
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        <property type="protein sequence ID" value="AEPI005879-PA"/>
        <property type="gene ID" value="AEPI005879"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005879"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005879-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Howell P."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
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                <person name="Shea T."/>
                <person name="Sisk P."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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            <end position="237"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="1189"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005919-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1224" mass="128299" checksum="F93824F14671FFB6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHF2</accession>
    <name>A0A182PHF2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHF2"/>
    <dbReference type="STRING" id="199890.A0A182PHF2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006361-RA">
        <property type="protein sequence ID" value="AEPI006361-PA"/>
        <property type="gene ID" value="AEPI006361"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006361"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006361-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="64" mass="7560" checksum="CFB375A138A4ED22" modified="2016-09-07" version="1">MYIINACLRCQAESKKDTLGRQDCVVVWGECNHSFHHCCMSLWIKQNNRCPLCQQEWSIQRMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHR9</accession>
    <name>A0A182PHR9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHR9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006479-RA">
        <property type="protein sequence ID" value="AEPI006479-PA"/>
        <property type="gene ID" value="AEPI006479"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006479"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131320" evidence="1">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006479-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="209" mass="19798" checksum="FD163D87359F0C83" modified="2016-09-07" version="1">MRGLVLFTLLVASTALLVEGQNVNIVLTANTDGSITLATSDGSQSVTIAADSPDLLSELITILDAIIANASTATAATTVGIGFGAGIGIGGLRLGGGIFGGVRRGTGIGGNVGAAGRIGTGGIIPGAIGLLGRGISGGINTVGNVLSAKTNFEGRSIYRGGTLGGGLARSAGNLIGGAAAGLGNVVGSVLGGVPRVGGSASLYASGRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIH8</accession>
    <name>A0A182PIH8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIH8"/>
    <dbReference type="STRING" id="199890.A0A182PIH8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006740-RA">
        <property type="protein sequence ID" value="AEPI006740-PA"/>
        <property type="gene ID" value="AEPI006740"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006740"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051110">
        <property type="entry name" value="Ly-6/neurotoxin-like_GPI-ap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16983:SF10">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16983">
        <property type="entry name" value="UPAR/LY6 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131348" description="UPAR/Ly6 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006740-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18540" checksum="7360413712AB63C4" modified="2016-09-07" version="1">MSIIIAIVFMGLLELGRSQYLTNTVHKTSAATEKINDLWCYSCNATDDGEACIDLSSGNNASYVKKCNPEEFICMVKQFSYTTSTENSTSTPKLWSLERRCISSCEAGCIIIGERTKLYACTSCCEKSLCNTGKAHSTNPIAHFRRTSTALALGMLVLLSVAKPTLSVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ16</accession>
    <name>A0A182PJ16_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJ16"/>
    <dbReference type="STRING" id="199890.A0A182PJ16"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006930-RA">
        <property type="protein sequence ID" value="AEPI006930-PA"/>
        <property type="gene ID" value="AEPI006930"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006930"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131457" evidence="5">
        <location>
            <begin position="29"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006930-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="196" mass="20561" checksum="7705FB302294F070" modified="2016-09-07" version="1">DRATPLFIAAQNGHSLVLKLLLAAGANADAPRKDGATPLWIAAQMGHDHVVKILLHNGALVDAVRCDGATALFKAAHKGHSAVVHELLKFRPNLGTLANGETALHAAVMFGHLPIVKQLVAVGADCTVANQDGYTPLQLARQQKFASVYQYLKEREQQDKQQPSAGTPKRTVVVGSPASNQSKASKGAAPSVAITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK29</accession>
    <name>A0A182PK29_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PK29"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007295-RA">
        <property type="protein sequence ID" value="AEPI007295-PA"/>
        <property type="gene ID" value="AEPI007295"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007295"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007295-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="154" mass="17092" checksum="1FDC6F47E2AF0971" modified="2016-09-07" version="1">MSHVRYNQRLQESYEQEWQQQQQQQEQEQEHDEWYRGSSERSSEDRSRSSQQLRQQPRQHQQQEDEDSIEEVVRLHQQQLQQQQQQQYYSAGPGSSSVRRRSAGVQVGGGGSGGGGVGCSGGAGGRGFVAAVGGVVGQGFLALRRTRARAGCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKI5</accession>
    <name>A0A182PKI5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKI5"/>
    <dbReference type="STRING" id="199890.A0A182PKI5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007452-RA">
        <property type="protein sequence ID" value="AEPI007452-PA"/>
        <property type="gene ID" value="AEPI007452"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007452"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007452-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="183" mass="21082" checksum="45DE5938D17F9B25" modified="2016-09-07" version="1">EKDVYGNEVQRLGRPLPVEYLLVDVPASTPLVPLYTFLERKDAKQYFPVENRMIDGHIQDFAALANYLAKSRSLPFLDAVSDFHLLFYLYRMEDMLPMKSQLGPLLEAVRTKDKAKANEWKTREVWKTLEELIEASSNHDDSSMSNDVEFVPSGDAEQNWICTFCTFINSRELPACEICNLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKV2</accession>
    <name>A0A182PKV2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">YEATS domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). Also able to recognize and bind crotonylated histone H3. May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo. Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z. H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Interacts with MLLT10/AF10. Also interacts with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKV2"/>
    <dbReference type="STRING" id="199890.A0A182PKV2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007569-RA">
        <property type="protein sequence ID" value="AEPI007569-PA"/>
        <property type="gene ID" value="AEPI007569"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007569"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16909">
        <property type="entry name" value="YEATS_GAS41_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1970:FF:000002">
        <property type="entry name" value="YEATS domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="YEATS" evidence="14">
        <location>
            <begin position="14"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007569-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="230" mass="26401" checksum="97620F3AA4A4039B" modified="2016-09-07" version="1">MNILTHFGPDSGGRVKGLTIVKPVVYGNVARSFGKKREEDGHTHQWTVYVKPYHNEDMQSYVKKIHFKLHESYANPNRIITKPPYEVTETGWGEFEIVIKIHFHDPTERPVTMYHILKLFQSPILDGEVSTQIEGKKGLVSEQYEELVFQEPTQLMQQQLTNVKPVTNGAWKHDTDFEEKQAQALENIIETKAKVISEIAQLKEKLKLARETIAKFKTEMAKVQGQQTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKW9</accession>
    <name>A0A182PKW9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKW9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007586-RA">
        <property type="protein sequence ID" value="AEPI007586-PA"/>
        <property type="gene ID" value="AEPI007586"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007586"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39959:SF2">
        <property type="entry name" value="RE44287P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39959">
        <property type="entry name" value="RE44287P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007586-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="64042" checksum="094585B8B247F4CC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKY5</accession>
    <name>A0A182PKY5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PKY5"/>
    <dbReference type="STRING" id="199890.A0A182PKY5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007602-RA">
        <property type="protein sequence ID" value="AEPI007602-PA"/>
        <property type="gene ID" value="AEPI007602"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007602"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000078">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="165"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="261"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="332"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007602-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="426" mass="48408" checksum="D539304DD5C5C1CC" modified="2016-09-07" version="1">MPGRFTARSMSQHRFNLQPACFDTDYLLNPANRAAIEANIQHRKGIGDIQLVQRLSEQLDAGQATLSKGERSALQAQLSAELGKIPNRTHPALLDYGTEPRIVARYNEQAKQTDRKYFQFGDICKRMNLYRMENLGNFTGHRSYYLTDELAELEHALICYAVDSLRERHFRLVTVPDVLPARIIESCGMSVHGERNQVYKLNGRHERDTLCLSGTSEMALAGYLAGRVLPADQLPQKLMAVSRCYRAETSALQEEKGIYRVHQFTKVEMFAVCQPDQSATVLEEFRDIEVALFNQLGLHFLLLDMPACELGAPAYRKYDIEAWMPGRGMYGEISSCSDCTDYQARRLGIRVRTADGRETFAHTVNGTACAIPRMLIATLENFQNADYTVTVPDVLRRYMGGKQLLRRRKVLPELKLAKRLVQEETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLD1</accession>
    <name>A0A182PLD1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLD1"/>
    <dbReference type="STRING" id="199890.A0A182PLD1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007749-RA">
        <property type="protein sequence ID" value="AEPI007749-PA"/>
        <property type="gene ID" value="AEPI007749"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007749"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000002">
        <property type="entry name" value="guanine nucleotide-binding protein G(Q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003977">
        <property type="entry name" value="Guanine nucleotide-binding protein G(q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000654">
        <property type="entry name" value="Gprotein_alpha_Q"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF329">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00442">
        <property type="entry name" value="GPROTEINAQ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="174"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="242"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="311"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007749-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="360" mass="42533" checksum="1E34973B211F927F" modified="2016-09-07" version="1">MECCLSEEAKEQKRINQEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFIKLVYQNIFMAMQSMIRAMDLLKILYSDPANIEHAELIRSVDFETVTTFEPPYVQAIKDLWADAGIQECYDRRREYQLTDSAKYYLMEIDRVAAPNYLPTEQDILRVRVPTTGIIEYPFDLEEIRFSYLSDLARIEKEDFLPTEQDILRARAPTTGILEYPFDLDSIIFRMVDVGGQRSERRKWIHCFENVTSIIFLVALSEYDQILFESENENRMEESKALFKTIITYPWFQHSSVILFLNKKDLLEEKIMYSHLVDYFPEYDDTENIRFVFAAVKDTILQSNLKEYNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLR3</accession>
    <name>A0A182PLR3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Ubiquitin carboxyl-terminal hydrolase 39</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">U4/U6.U5 tri-snRNP-associated 65 kDa protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PLR3"/>
    <dbReference type="STRING" id="199890.A0A182PLR3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007885-RA">
        <property type="protein sequence ID" value="AEPI007885-PA"/>
        <property type="gene ID" value="AEPI007885"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007885"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:spliceosomal complex assembly"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="25">
        <location>
            <begin position="39"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="24">
        <location>
            <begin position="162"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023187"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007885-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="497" mass="58205" checksum="EF87669D53A01E10" modified="2016-09-07" version="1">QQSAPPIKKPKLEDVLDEDEGNSGQQIQRRKQTVTDRSKQCPYLDTINRHLLDFDFEKLCSVSLTRINVYACLVCGKYFQGRGTNTHAYTHSVAESHHVFLNLSTLKFYCLPDNYEIIDSSLDDIKYVLDPVFTVRDIRSLDREDVKQSRTVDGTFYHPGVVGLNNIKANDYCNVILQALSHVKPIRDFFLMEKNYANIKRPPGDTAFTLVQRFGELLRKLWNPRNFKAHVSPHEMLQAVVLWSNKQFQITKQGDPIEFLSWFLHSLHKQLRGNKQPDSSVINRSFLGEMKIYTRKLPPTELDDVQKQLLLATDEYQEKEETSTFLYLTCDLPATPLFIDELRENIIPQVNLYQLLAKFNSISEKEYKTYKDNFLKRFEITRLPKYVILYIKRFTKNTFFLEKNPTIVNFPVKNVDFGDILTEENKKTHRYTKYNLVANIVHDGEPNSGTYRCHILQKSTNQWYEMQDLHVTNILPQMITLTEAYIQIYELQENDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLV2</accession>
    <name>A0A182PLV2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PLV2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007924-RA">
        <property type="protein sequence ID" value="AEPI007924-PA"/>
        <property type="gene ID" value="AEPI007924"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007924"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000007">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily C, member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000518">
        <property type="entry name" value="Receptor mediated endocytosis 8, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044978">
        <property type="entry name" value="GRV2/DNAJC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045802">
        <property type="entry name" value="GRV2/DNAJC13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14237">
        <property type="entry name" value="GYF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19432">
        <property type="entry name" value="RME-8_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1931"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2475"/>
            <end position="2497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1943"/>
            <end position="1953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007924-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2497" mass="282048" checksum="50EF7B70762A9275" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLW5</accession>
    <name>A0A182PLW5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLW5"/>
    <dbReference type="STRING" id="199890.A0A182PLW5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007937-RA">
        <property type="protein sequence ID" value="AEPI007937-PA"/>
        <property type="gene ID" value="AEPI007937"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007937"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000077">
        <property type="entry name" value="Kirre like nephrin family adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF136">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007937-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="113" mass="12492" checksum="09DC7571726EC4CB" modified="2016-09-07" version="1">LPFLVQCTAEQQKFRLTPVDLVVAEGAEALLRCEIHNAAGSVQWTKDGFALGFTQSIPGYPRYSVLGDSGQGIYNLRIVNVTLDDDAEYQCQVGPYMHHKLIRAKARLTVIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLX4</accession>
    <name>A0A182PLX4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLX4"/>
    <dbReference type="STRING" id="199890.A0A182PLX4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007946-RA">
        <property type="protein sequence ID" value="AEPI007946-PA"/>
        <property type="gene ID" value="AEPI007946"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007946"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF317">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007946-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="239" mass="26076" checksum="1810C19A14F02679" modified="2016-09-07" version="1">MFWVSSPQHQQSYHRNYEEYVHPMQQQQQQQQQQQHNAAASSPLSTLSQHGSMMAPQSPSMLGGTNGMMPSPLMQSHSPLLSSNASLLQSQSPLLSSSPLMSQYSPYHHQDVPMPTILPQDEPGGGGGGGAGGWGGYALTAAGPYQSEFCASNYGVLHQRQAYGGPHGPGKLGPHGGLKSAKEARIRRPMNAFMVWAKVERKKLADENPDLHNADLSKMLAERLSDKIMRSVFFSVEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLX7</accession>
    <name>A0A182PLX7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLX7"/>
    <dbReference type="STRING" id="199890.A0A182PLX7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007949-RA">
        <property type="protein sequence ID" value="AEPI007949-PA"/>
        <property type="gene ID" value="AEPI007949"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007949"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007949-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="936" mass="101996" checksum="17D110C0FCF2A2B6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMM8</accession>
    <name>A0A182PMM8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease H1</fullName>
            <shortName evidence="8">RNase H1</shortName>
            <ecNumber evidence="8">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A182PMM8"/>
    <dbReference type="STRING" id="199890.A0A182PMM8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008202-RA">
        <property type="protein sequence ID" value="AEPI008202-PA"/>
        <property type="gene ID" value="AEPI008202"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008202"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000097">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF31">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="10">
        <location>
            <begin position="131"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008202-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="286" mass="31094" checksum="AA121413F7C8F546" modified="2016-09-07" version="1">MSFRQLLQLLRVLPRMPYYAVAKGRQVGIFSTWPECQAQVNGFTGARFKKFPTEAEAKAFIATNGGNGGSVLAGKKPSTAPSWSGKRSASSSSTNGETPNKQPKKTILLEKAPAPVSKLVKHGLYSFLEDDNGFVHVYTDGSCEGNGTARAVAGLGVYFAEGHALNTAKPVSGRATNNCGEIQAASLAIRLARGQGIRRLVVNTDSQFLINAITKWLPGWKKRNWTLASGGPVKNKTDFVELERELSSGDIEIKWNHVDAHCGILGNERADQLARKGSEMYRMQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN49</accession>
    <name>A0A182PN49_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN49"/>
    <dbReference type="STRING" id="199890.A0A182PN49"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008373-RA">
        <property type="protein sequence ID" value="AEPI008373-PA"/>
        <property type="gene ID" value="AEPI008373"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008373"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008373-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="383" mass="44393" checksum="96272C8B6D49D6F9" modified="2016-09-07" version="1">MSEHPIHDFDRLIRRQRLLLKLIGLDSYDPTFRPRITIMVVCLSLIFVAISMYDLYIFRNDLFNFVYVLITIFFASIGIGHICVFVCYRDVLPMMLEQSYDTYRLVGKDERELHILQWYTKLFKRGANVYSLMFIGTSILTGLLPIAIYQLTGERVLPYGVVLPFVDPDSQVGYELNYMYQVSCIIWTPPGLVGAQCMMFGVVLNICVQYDILGVKLHDLDKLIRSGEESAQREELIGKKLRVILRDQQRLISFISHVEEANTVMAGVEILSFGLQIVITLYVLQLAFWFPGYVIIVLATMQLFILCLLGTIIEYKGEKFSEAVYQLTWNELSRGHKKIFRLLLLSSQQPYILTWSGMTNINMNLFVGMSQKFYSIFMMLRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP01</accession>
    <name>A0A182PP01_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Galactosyltransferase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP01"/>
    <dbReference type="STRING" id="199890.A0A182PP01"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008680-RA">
        <property type="protein sequence ID" value="AEPI008680-PA"/>
        <property type="gene ID" value="AEPI008680"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008680"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="33"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="170"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008680-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25109" checksum="BD958FA254988A6B" modified="2016-09-07" version="1">MVKSNDNLIDQPASKDGISSAENLSDKFTITSCPPIPSNLDGPIDVDVAFEPLSVVEKRFADKLQPGGQYVPPDCTARNRVAIIVPYRDREQHLPIFLKNIHSLLMKQQLEYGVYIVEQTAGSSFNRAALMNIGFVEAMKQKNWECMVFHDIDLLPMDDRNLYTCPDQPRHMSVAVDTFGFKLPYSTIFGGVSAMTEKQFRMVNGFSNSFWGWGGEDDDMSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP91</accession>
    <name>A0A182PP91_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase III subunit RPC4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP91"/>
    <dbReference type="STRING" id="199890.A0A182PP91"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008770-RA">
        <property type="protein sequence ID" value="AEPI008770-PA"/>
        <property type="gene ID" value="AEPI008770"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008770"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008770-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39603" checksum="655C0AF76AA9A1B3" modified="2016-09-07" version="1">MDHSPRIKQEPGIDTPYLAKSNNLIGNVAVPMEATVKTERLQSFRVPRDLTLANGRTTKPPNNKKVYTPNLNAVRNKNTDVKTASSGPKGRVKTDRNRNDKDARNKKNTLIQTSGIFSDGLAQRALTRASRSEKSSSSKEPGDSIQKPVFARANAKIDLEDERQRIQNLCEDMDDDVAELDQKMANGLKLPVKLENSDYKIKPPEVKTENVPVTKLDSFNSIENVLSGEQTNKIFLLQLPDALPGKSDDGNKRGGTNGEDSKSETPATGEETPQYCTVRDLAEGYIGKIIKYRSGKVKLKLGEIMFDISLGMDTGFLQELVSINTNPVERSGNMINISTINTKLNASPDWEYLFKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPE1</accession>
    <name>A0A182PPE1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPE1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008820-RA">
        <property type="protein sequence ID" value="AEPI008820-PA"/>
        <property type="gene ID" value="AEPI008820"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008820"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF13">
        <property type="entry name" value="LETM1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="9">
        <location>
            <begin position="200"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008820-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="381" mass="44576" checksum="CE43FFA46048890F" modified="2016-09-07" version="1">MSLALLRTLCRHQQHVLQQRQPVSFVSSSAARCAIRFQSTTGSDDGPKQDGNDKQSTKERLAVKYSRENVKRNVQGYVFSRFFDYVKNYDKVIEKKFPSAVHVYRVFLVGVRDFFNDMKKLVKVTKIVYSHDNDLRCLTRKEIELYYQMPRDMKKVAPVLLISALPFANYVIFPLAYMYPRTLLTSHFWSAQQKVDFAQIDLRNRLLYNRRVFRCMQSKLDALKKTHDPAYEKFSYILGLLGSGLHPTSEEILDVKDVFQRPPFHLNSLSSSHLKYLCRLHDIHAVLLRRFRLSERAYVVHHMDMAIKREGGVHNMPIESLKNACYIRGLNANNMSAESMIEWLQEWVRVSLVVDEDCISMLLHLPILLSYNHTSNWILIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPY4</accession>
    <name>A0A182PPY4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PPY4"/>
    <dbReference type="STRING" id="199890.A0A182PPY4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009014-RA">
        <property type="protein sequence ID" value="AEPI009014-PA"/>
        <property type="gene ID" value="AEPI009014"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009014"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000594">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000017">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="12">
        <location>
            <begin position="210"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009014-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="501" mass="57088" checksum="EDC348A0201A5E89" modified="2016-09-07" version="1">MSSTPEETNHKSEKPAAVVAPETTAEENPLQAKADELGARGNEYFKEQNYEQAIALYTEAIETCPNERFYANRSFAHFRTESYGYALCDADQAIAMKSSYTKAYYRRAAALMALGRFKKALADLEFVAKRCPSAKDAQDKYTECKKMVNKIAFEKAISVQHQEKSVEKMCRDLEFATIEDDYTGPKLENGKVTLEFMESLLEWYKKQNKLHKNFAYRILCDMESLLKTQPSLVEINVPDEQKFTVCGDIHGQFYDLLHIFEINGLPSPTNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESFNMNQLYGFTGEVVSKYSQNMADMFTLVYNWLPLCHLINKKVLVMHGGLFSKDNVSLDDLRAIDRNCQPPEEGLMCELLWSDPHPLQGRVPSKRGVGIQFGPDVTEAFLKYNNLDYIIRSHEVKAEGYEVDHNGKCITVFSAPNYCDQMKNLGAFITLKGNDLTPKFTTYADSPHPSIRPMAYAYSLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQF7</accession>
    <name>A0A182PQF7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MELT/VEPH family.</text>
    </comment>
    <dbReference type="EnsemblMetazoa" id="AEPI009188-RA">
        <property type="protein sequence ID" value="AEPI009188-PA"/>
        <property type="gene ID" value="AEPI009188"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009188"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01264">
        <property type="entry name" value="PH_MELT_VEPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039888">
        <property type="entry name" value="Melted-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21630:SF10">
        <property type="entry name" value="VENTRICULAR ZONE-EXPRESSED PH DOMAIN-CONTAINING PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21630">
        <property type="entry name" value="VEPH-A/MELTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1271"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1308"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="1062"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="775"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="982"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="995"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009188-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1364" mass="146694" checksum="3DCC16690ABE05D8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQI0</accession>
    <name>A0A182PQI0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mandelate racemase/muconate lactonizing enzyme N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQI0"/>
    <dbReference type="STRING" id="199890.A0A182PQI0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009211-RA">
        <property type="protein sequence ID" value="AEPI009211-PA"/>
        <property type="gene ID" value="AEPI009211"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009211"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009211-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="145" mass="16311" checksum="E05D7EF9F050CA09" modified="2016-09-07" version="1">MGKDRCLNITRLLAKDIRWPTSLGAHGSDAMHTDPDYSCVYVTIETAEGIAGYGMTFTLGRGTDIVLLAVRAMARMVEGRTTASIFERFGQFWRELTSDSQLRWIGPEKGVTHLAVAAIINALWDLWGRIRNVPVWRLLTEMEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR86</accession>
    <name>A0A182PR86_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PR86"/>
    <dbReference type="STRING" id="199890.A0A182PR86"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009468-RA">
        <property type="protein sequence ID" value="AEPI009468-PA"/>
        <property type="gene ID" value="AEPI009468"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009468"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002066">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009468-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="298" mass="33845" checksum="6AE65D6197232A51" modified="2016-09-07" version="1">MRYGQLVMGPAGSGKSTYCATMQRHGFDDKRLIKVVNLDPAAENFDYQPFLDIRDLIQLDDAMEDEELRYGPNGGLIFCIEYLIEHSDWLRDQLCGVGSDDDDDDTTGIEEPDDDYVLFDMPGQIELYTHLKAGHSLARLLESWNFRLCSVFLVDSQFMIDGAKFLSGTMAALSVMANMELPHVNVLSKMDLLSKGHRGQMDKYLDPDAHALLGEVTNESAWGRKYRKLSETIGTLIEDFSLVRFTPLNINDEENVADLLLMIDNVIQYGEDADVKVRDFDPPEPDELEDDSRYYQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRX1</accession>
    <name>A0A182PRX1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRX1"/>
    <dbReference type="STRING" id="199890.A0A182PRX1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009706-RA">
        <property type="protein sequence ID" value="AEPI009706-PA"/>
        <property type="gene ID" value="AEPI009706"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009706"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF42">
        <property type="entry name" value="FI18455P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131753" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009706-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="169" mass="19273" checksum="B1F99B272C5052B5" modified="2016-09-07" version="1">MLKFAAIATVGLLVVAVQCVKVDYYGSLYNPKDELHAPYHEKEDKQDFSKIPGVPGVDYPIYHEVPHTSFHCGNVPAIPGMYANVETGCQAYHTCHDGREGHQGASFLCTNGTLFNQKEFACDWWYNVKCEDAPSYYHLNADPEHNPFTPKRKPEEEEHQHHKKFLIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS79</accession>
    <name>A0A182PS79_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAM86 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PS79"/>
    <dbReference type="STRING" id="199890.A0A182PS79"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009814-RA">
        <property type="protein sequence ID" value="AEPI009814-PA"/>
        <property type="gene ID" value="AEPI009814"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009814"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029426">
        <property type="entry name" value="FAM86_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14904">
        <property type="entry name" value="FAM86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAM86 N-terminal" evidence="3">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009814-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="349" mass="38642" checksum="7F9D131DAE473346" modified="2016-09-07" version="1">MKPSDCLETTVEANVSPAVAATDSNRIDESALKLGLLEHELTWDEQAALLDATVDHPLVQRYPLSVEYQAAFLKYIIAHLSNMNVEHHDRMYENYCAMLSPGTDLPLDDPSIGLSYKHYELPHGQGVISLKESGAFVSDGTTGLCSWQAAKALCEHISNNRDDFHGRNILELGSGVGLSGIYLAKCYEPSIIVMSDCHSSVLTALKENVRLNFPNAAPVECDNPLVSLLLDSGNTLIGVMDLDWQYISASNLSQLIEPDVIVAADIVYDHTLFPALLSTLNYIFCLSNNRCKFVLACTERNQDTLNEFLQLLITAKFRINEEAVSPSRHFHWDSSASTIRIFTISRAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSC8</accession>
    <name>A0A182PSC8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PSC8"/>
    <dbReference type="STRING" id="199890.A0A182PSC8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009863-RA">
        <property type="protein sequence ID" value="AEPI009863-PA"/>
        <property type="gene ID" value="AEPI009863"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009863"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009863-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="130" mass="15019" checksum="2F23235366A374E9" modified="2016-09-07" version="1">MSAPGFYPDPTNCTRYLYCDAEMLSYEQSCVANNVYNQTSASCFLKRRSTDCFQVDCKNSRNKDKWFVYTPSPQLYFLCSANGAIMFKCPRENDVFDLELKRCEFACREAGRFAHPNPAMYYECAYISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSK4</accession>
    <name>A0A182PSK4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PSK4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009939-RA">
        <property type="protein sequence ID" value="AEPI009939-PA"/>
        <property type="gene ID" value="AEPI009939"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009939"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000096">
        <property type="entry name" value="eIF-2-alpha kinase activator gcn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000162">
        <property type="entry name" value="GCN1, eIF2 alpha kinase activator homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1353"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1527"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1646"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1994"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009939-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2663" mass="293100" checksum="5EF62D5BCB71230E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTP1</accession>
    <name>A0A182PTP1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">protein kinase C</fullName>
            <ecNumber evidence="5">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PTP1"/>
    <dbReference type="STRING" id="199890.A0A182PTP1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010327-RA">
        <property type="protein sequence ID" value="AEPI010327-PA"/>
        <property type="gene ID" value="AEPI010327"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010327"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20795">
        <property type="entry name" value="C1_PKD_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20796">
        <property type="entry name" value="C1_PKD_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01239">
        <property type="entry name" value="PH_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000137">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000021">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000068">
        <property type="entry name" value="Serine/threonine-protein kinase D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057764">
        <property type="entry name" value="Ubiquitin_PRKD1-3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25525">
        <property type="entry name" value="Ubiquitin_PRKD1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="22">
        <location>
            <begin position="122"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="22">
        <location>
            <begin position="273"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="20">
        <location>
            <begin position="466"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="619"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="321"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010327-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="915" mass="100909" checksum="53726FD88157ADDB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU02</accession>
    <name>A0A182PU02_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PU02"/>
    <dbReference type="STRING" id="199890.A0A182PU02"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010438-RA">
        <property type="protein sequence ID" value="AEPI010438-PA"/>
        <property type="gene ID" value="AEPI010438"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010438"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131964" evidence="2">
        <location>
            <begin position="20"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010438-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="628" mass="69330" checksum="EB886C3259C6149C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU75</accession>
    <name>A0A182PU75_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU75"/>
    <dbReference type="STRING" id="199890.A0A182PU75"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010511-RA">
        <property type="protein sequence ID" value="AEPI010511-PA"/>
        <property type="gene ID" value="AEPI010511"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010511"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051307">
        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010511-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="164" mass="17884" checksum="4BBA79166C7E61ED" modified="2016-09-07" version="1">MISDVQLAVFCNVLGVFLFLLVVAFHYINANMGSLNMISDVQLAVFCNVLGVFLFLLVVAFHYINANMGRGYSLFSITCGVLREELFEMFLYVKDFLSFTNDVSKLNTFSGSLLLSSEGVRHSCSVAAMESGPTGTATNDEDVTVGVMAAMGCVARFCLSIRCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV22</accession>
    <name>A0A182PV22_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PV22"/>
    <dbReference type="STRING" id="199890.A0A182PV22"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010809-RA">
        <property type="protein sequence ID" value="AEPI010809-PA"/>
        <property type="gene ID" value="AEPI010809"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010809"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000100">
        <property type="entry name" value="Cyclic nucleotide-gated cation channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF4">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="184"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010809-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="445" mass="50618" checksum="7F0B229AE4EB846B" modified="2016-09-07" version="1">MHLAPPPLEAVGSDFNTIQSSADHNRNSVSRQSLMDIVSSKLGMSGPQLGQSISQQGFFSSRDSLSASGTSRPLHSHVSATTSEMDLSRKDRKRERSKLKAADPPLLGSWSRTGPRESNANAMGPCATVRASTNHLAAPCGTGSTCNGADRYIFGRRSGCSTTSRKSNGRRWSFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINGESIVLWFCLDYFSDFLYLVDILFHFRTGYLEDGVLQTDSTKLRQHYMNSTTFYIDCLCLLPLDFLYLSIGFNSILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTSLIHYLLVIFHWNGCLYHIIYKNNGFGSKNWVYHDSESADVVKQYLQSYYWCTLALTTIGDLPRPRSKAEYVFVIAQLLFGLMLFATVLGHVANIVTSVSAARKEFQGKWMREAGPGGRFRRPEKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV30</accession>
    <name>A0A182PV30_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquitin-conjugating enzyme E2 J2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PV30"/>
    <dbReference type="STRING" id="199890.A0A182PV30"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010817-RA">
        <property type="protein sequence ID" value="AEPI010817-PA"/>
        <property type="gene ID" value="AEPI010817"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010817"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000023">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010817-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="247" mass="27680" checksum="F7FA5AD8DA3F25FF" modified="2016-09-07" version="1">MTNQKPTATCRLKQDYMRLKRDPVPYITAEPLPSNILEWHYVIKGPEDSPYYGGYYHGTLLFTKEFPFKPPSIYMTTPNGRFKTNKRLCLSISDFHPDTWNPAWSVATILTGLLSFMLESTPTMGSCETTPAEKRRYAQLSLEFNMKNEVFQELFPEICEEISERLQKIEEQRKLAAAASAENGGTGPDGANGDGETTDGGGMFVAGGRSGIDDSNIWHSLYTNLIVLVGFVVFALIVHYVIKSMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVQ5</accession>
    <name>A0A182PVQ5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
            <ecNumber evidence="11">7.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.1.3" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182PVQ5"/>
    <dbReference type="STRING" id="199890.A0A182PVQ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011042-RA">
        <property type="protein sequence ID" value="AEPI011042-PA"/>
        <property type="gene ID" value="AEPI011042"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011042"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140571">
        <property type="term" value="F:transmembrane ascorbate ferrireductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF43">
        <property type="entry name" value="ASCORBATE FERRIREDUCTASE (TRANSMEMBRANE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="29"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011042-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="237" mass="27000" checksum="72DDA0BA175A49BE" modified="2016-09-07" version="1">MHNTSEKELVPDRKLKATENEWFSMAEGIFNTLNHTMIGVVCIYTSWLCWMNGFEKLYTWHVFLTLIGYHLLMAEGIVLLYSGNGWTQKLSHSHKRTVHWLIEVVGCACCVVGIALEIYFRESTNRRHFSSSHSIVGLVSFAFLVLTLVNGLMALFATELRRRIRPIYSKLSHYLTGTVCYVLGMVAIVLAYEKKIYRQNTITEGITMMTVFTIAVTVLSMVGVVKTVYNQVKTLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVR7</accession>
    <name>A0A182PVR7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVR7"/>
    <dbReference type="STRING" id="199890.A0A182PVR7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011054-RA">
        <property type="protein sequence ID" value="AEPI011054-PA"/>
        <property type="gene ID" value="AEPI011054"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011054"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="1">
        <location>
            <begin position="222"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011054-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="59413" checksum="E5A02C63E8174C68" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW62</accession>
    <name>A0A182PW62_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PW62"/>
    <dbReference type="STRING" id="199890.A0A182PW62"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011199-RA">
        <property type="protein sequence ID" value="AEPI011199-PA"/>
        <property type="gene ID" value="AEPI011199"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011199"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000475">
        <property type="entry name" value="GTP-binding protein Rhes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF7">
        <property type="entry name" value="GTP-BINDING PROTEIN DI-RAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011199-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="148" mass="16955" checksum="DF8AE6A33AA09AB5" modified="2016-09-07" version="1">MSDFERIRLVILGGAGVGKSCIIKRFLFKTYSDKYRPTVEDLYNREYDLGSVTLKVDILDTSGEMQFPAMRRLSIATAHAFLLVYATTSEASLGCVKQCFEEIREQRADFQDIPMVIVGNKYDLTASHREVRIEDVSEWVFCELPKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWP8</accession>
    <name>A0A182PWP8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transposase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWP8"/>
    <dbReference type="STRING" id="199890.A0A182PWP8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011385-RA">
        <property type="protein sequence ID" value="AEPI011385-PA"/>
        <property type="gene ID" value="AEPI011385"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011385"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022242">
        <property type="entry name" value="TNP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12596">
        <property type="entry name" value="Tnp_P_element_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP9-like helix-turn-helix" evidence="2">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="4">
        <location>
            <begin position="190"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="5">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like C-terminal" evidence="3">
        <location>
            <begin position="505"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011385-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="75088" checksum="27D2E992A67025B8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWS6</accession>
    <name>A0A182PWS6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWS6"/>
    <dbReference type="STRING" id="199890.A0A182PWS6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011413-RA">
        <property type="protein sequence ID" value="AEPI011413-PA"/>
        <property type="gene ID" value="AEPI011413"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011413"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055510">
        <property type="entry name" value="DUF7083"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23309">
        <property type="entry name" value="DUF7083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011413-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="210" mass="23508" checksum="6880C1EC92947D4A" modified="2016-09-07" version="1">MPPPTELGSTAPMENVTGQSFQATILQLLSNQQALMCRMAEQMENIQENVQSTSRNELVLDSLASNITEFAYDLQQGNTFDGWFSRYVDLFEKDASKLDDAAKNHKCRDCGQTGHKEGYCSCFTSKTNFKRFTPKQQNHATKIVTVNNVKRSRRFVETVINGVPVELQLDSGSDMTIISKQNWFKIGAPQTSLPDCKVQTASGDRLQIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX68</accession>
    <name>A0A182PX68_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX68"/>
    <dbReference type="STRING" id="199890.A0A182PX68"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011555-RA">
        <property type="protein sequence ID" value="AEPI011555-PA"/>
        <property type="gene ID" value="AEPI011555"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011555"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011555-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="146" mass="16578" checksum="8440CC27701CEB9D" modified="2016-09-07" version="1">TSSVDRQQFRLVQHQAKLFWDKWKKEYLPTLVKRDKWTSKVVPIKQGDIVVITDDNAPPGVWLKGRVIKAHLAKDEQDSPSVRIGPCKLGATSWKAALRRESLSVETLREGARPWLARSASFDDGKQRAYIAVRSPEASRDQSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX76</accession>
    <name>A0A182PX76_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX76"/>
    <dbReference type="STRING" id="199890.A0A182PX76"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011563-RA">
        <property type="protein sequence ID" value="AEPI011563-PA"/>
        <property type="gene ID" value="AEPI011563"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011563"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011563-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="339" mass="38244" checksum="AB38D82D23247937" modified="2016-09-07" version="1">MFSDNDDEDDDSFLKNDNVLTLDKLSVVDGIRYWALSTNATHKSIDMVLKLFRKVNVKVPATAKTLLQTKRNASSEIMEIGGGQFWYHGIKKCLCNHYRYDKPPSKQLTLTISIDGLPLHNSSAMQFWPILFKIVEDSQAPVMTAAIFCGYKKPESTEQYLRPMVEELNDLISNGLDMHGENVAVKLLAIVADTPARSFVKGVTSHTGYRSCLKCTIEGEYVGHTVTFVGLNAPKRSDQAFRNDAYPGHRKMYTPLLDILFFDTIEDICVADRMHLIGLGATKRLLLGWRDGTLGIKRWTEKQCEQISEAFQKVLKPLEVHSKRLETTPSQIPQSLESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX86</accession>
    <name>A0A182PX86_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4219 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX86"/>
    <dbReference type="STRING" id="199890.A0A182PX86"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011573-RA">
        <property type="protein sequence ID" value="AEPI011573-PA"/>
        <property type="gene ID" value="AEPI011573"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011573"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011573-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="137" mass="15761" checksum="281FFFF70F343CB2" modified="2016-09-07" version="1">MGDLKFAIEKLHGSNWQTWSVRIEMLLTRDDLWEVVEQDVPDEAARTAAWKAKDRKAKATIILLIEDSQLPLVKNAVCAHDVYSALKQYHQKTTRSVRVSLLKKLCATNLAENGNLEDHLRIFDDLFDRLEALRTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ09</accession>
    <name>A0A182PZ09_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZ09"/>
    <dbReference type="STRING" id="199890.A0A182PZ09"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015077-RA">
        <property type="protein sequence ID" value="AEPI015077-PA"/>
        <property type="gene ID" value="AEPI015077"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015077"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015077-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="440" mass="48910" checksum="0FDD7A8F76B50D83" modified="2016-09-07" version="1">MARLKTFGAWSSSLGLQTAIIPLHVVAKVSCLNAFTYLPLSQCIGRHVACKSDGSIEAGTAVVCNKRCRVINDKTLAFSFVGLLHALGCSVVYASYHILSSLSQSGKLTDSNLVRVAIDLKNQYIGCMLVIGLVTVSLMRQPALDRLIQALLSVDRAIPEMVQAGELLTLKRFAPNNVCWLRLNVLLMLVLGVGVKAVLEVSNCLMYIRDSGSPFSSNCLLLCIIPQTLCVISELQFVAYALLISDRLRLLNRWLVQLQPHLARGSDAAFRSVRHLIPIHGKLLSAIELLNHCFGVQNAILLLYQFVTLVELGYNTCMMSVRFAEANIQQGDSTEDFLETVYWVAWFLVEIFTLCYFSHDTVEEAGRTIQLLKMPNAYEMNQRNYFRTVSQEQLVFLNVKTRVSCGGLFAVDLTLLHAIIGATTTYLIILIQFDQTFNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ74</accession>
    <name>A0A182PZ74_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZ74"/>
    <dbReference type="STRING" id="199890.A0A182PZ74"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015139-RA">
        <property type="protein sequence ID" value="AEPI015139-PA"/>
        <property type="gene ID" value="AEPI015139"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015139"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015139-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="396" mass="45751" checksum="D1CF32F16CF27B63" modified="2016-09-07" version="1">MHRVALQHYPKSDFNVTHRLVTIMVPIKTDTAFYHALLIKKFHLLLNISQFGGFLPFPSYVLRQDVDRRHFRTLVLAGLNLAFGVLTFCISLTCYLIMYIYYPDLMYKENLPAVLLIMYHVENWLRVVMVLIALVAPRLSGRFFRETLDTLVHVMKLFDHAGKIERVLGSNATVTNRLLLLYCCHALIITTVVWISTHHPISTLLNVCFLAPYMTTVLYILLYRTLLQSVAGFAGCLNDTLHAITLQDKFEPRRSTYGKHTTISYIKVHDGKQRESQSSRVDVATLEKLSMLHMALMRLARDTNKHFGLLILVIVLATFIFINMLLLELYHNIGSPVLPEYCLWVLLLHAFAHFTFFFVIAKSNHSIQQENERTMVLLHEFKCSWNSEQNMAVSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PK82</accession>
    <name>A0A240PK82_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Luciferin 4-monooxygenase</fullName>
            <ecNumber evidence="4">1.13.12.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>firefly D-luciferin + ATP + O2 = firefly oxyluciferin + hnu + AMP + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10732"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16792"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58038"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.13.12.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.7" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A240PK82"/>
    <dbReference type="STRING" id="199890.A0A240PK82"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015277-RA">
        <property type="protein sequence ID" value="AEPI015277-PA"/>
        <property type="gene ID" value="AEPI015277"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015277"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF423">
        <property type="entry name" value="GM05240P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0455">Luminescence</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-0599">Photoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="14">
        <location>
            <begin position="33"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="15">
        <location>
            <begin position="447"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015277-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="538" mass="59588" checksum="B2B7260E99FAF0C1" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PKZ7</accession>
    <name>A0A240PKZ7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A240PKZ7"/>
    <dbReference type="STRING" id="199890.A0A240PKZ7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015291-RA">
        <property type="protein sequence ID" value="AEPI015291-PA"/>
        <property type="gene ID" value="AEPI015291"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015291"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015291-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="429" mass="47549" checksum="0CCF8775F147C252" modified="2017-10-25" version="1">MSNIPPINSRVYVGGLGEQAKVEEFEELFKDFQPYQDLTLLRGFGFIQFHTEQAAQAAIKAMNGKMFNGRKLMVKVANDNRAKKGLLPRGAAPAPSGMAGVPSAATRDRSPVEAIHPIKRGYHPQQYSVADLSSVYPETPIGQAPHRGIESNDCEIIVVNKELTPYAELIEARLKRAGLSVDLLFPNNDVPIGKVLANRASQGTYYCIVITPENQERNSITVNVLYGIPAEHRNMPTDDAIDFIVKNFDEKIRSELTSHSRAGYHRAAPAVHPQLHPIPLRSEPAQAHEKHPEAIQNMINLLAANRSLTVLQYERLIKYLNERKEMQIRLELGEDVDSTTASSLIPPIGSAAPVKSKQETERELQKKILDIMNKPSIIGITKPVTSPDTKQSTGNMPTSTLLHDPKVQRALDSLLQSQMFSNVNVGYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PL19</accession>
    <name>A0A240PL19_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="16">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="16">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PL19"/>
    <dbReference type="STRING" id="199890.A0A240PL19"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015361-RA">
        <property type="protein sequence ID" value="AEPI015361-PA"/>
        <property type="gene ID" value="AEPI015361"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015361"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000009">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000013">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000003">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000003">
        <property type="entry name" value="Aldehyde oxidase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.120:FF:000007">
        <property type="entry name" value="indole-3-acetaldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000019">
        <property type="entry name" value="indole-3-acetaldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0408">Iron</keyword>
    <keyword evidence="11 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="171"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="1168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="844"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="996"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015361-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1224" mass="134466" checksum="37D975E3EDF2B61C" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PNE2</accession>
    <name>A0A240PNE2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PNE2"/>
    <dbReference type="STRING" id="199890.A0A240PNE2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015338-RA">
        <property type="protein sequence ID" value="AEPI015338-PA"/>
        <property type="gene ID" value="AEPI015338"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015338"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF50">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013394550" description="Peptidase S1 domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="55"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015338-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="300" mass="32236" checksum="CD46616561191BB9" modified="2017-10-25" version="1">MKTFVLLVGLLAVASAEWIEIDWSQVRPIEDFDHYWERLPAELQVYRKLRPPQRIVNGQEATPGQFPYQIALLSEFLTGTGLCGGSVLTNNFILTAAHCVVSGATTLARGGTAIMGAHNRNIQEPSQQRIRFSTGGIIRHPQYTTTNIRNDIAVVRLDAPIVFNDRVQPARLPARSDTRQFGGFTGTVSGFGRTSDGSQATSAVVRFTSNPVMTNADCIARWNTALIQPQNVCLSGEGGRSACNGDSGGPLAVQDGGSLQIGIVSFGSAGGCSIGMPSVYARVSFFLSWIEANSDFVARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PPP6</accession>
    <name>A0A240PPP6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">FCS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A240PPP6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015274-RA">
        <property type="protein sequence ID" value="AEPI015274-PA"/>
        <property type="gene ID" value="AEPI015274"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015274"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20100">
        <property type="entry name" value="MBT_dSfmbt-like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09580">
        <property type="entry name" value="SAM_Scm-like-4MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037605">
        <property type="entry name" value="Sfmbt_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012313">
        <property type="entry name" value="Znf_FCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038603">
        <property type="entry name" value="Znf_FCS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF104">
        <property type="entry name" value="POLYCOMB PROTEIN SFMBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21319">
        <property type="entry name" value="zf-FCS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51024">
        <property type="entry name" value="ZF_FCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FCS-type" evidence="15">
        <location>
            <begin position="346"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="12">
        <location>
            <begin position="558"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="12">
        <location>
            <begin position="677"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="12">
        <location>
            <begin position="786"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="12">
        <location>
            <begin position="904"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="1294"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="397"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1012"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1173"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1233"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1016"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1174"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1189"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1204"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015274-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1375" mass="150462" checksum="D576BD5D51478751" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FHA6</accession>
    <name>A0A9I3FHA6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A9I3FHA6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015491-RA">
        <property type="protein sequence ID" value="AEPI015491-PA"/>
        <property type="gene ID" value="AEPI015491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052295">
        <property type="entry name" value="Odorant-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066:SF3">
        <property type="entry name" value="IP02236P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066">
        <property type="entry name" value="ODORANT-BINDING PROTEIN 59A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015491-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="153" mass="17350" checksum="324CB4986EA4B760" modified="2023-06-28" version="1">MCSSIHYFLLKQSLMPYCCEMEPLVPEHVDNQCQEQEAANYNPGSKQHEVCYLRCVYETLGVVNGSKVQVEKLYDLAKGFPADYRQAVHLAIDECSSRLHKTRNMFEQTGVPCSLLGFAVDRCVRLLIYGNCPTARWSSSITCTKVRQGLPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZG5</accession>
    <name>A0A182NZG5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohormone-3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZG5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000045-RA">
        <property type="protein sequence ID" value="AEPI000045-PA"/>
        <property type="gene ID" value="AEPI000045"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000045"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130738" description="Prohormone-3" evidence="1">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000045-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23445" checksum="7223846B5E55AB06" modified="2016-09-07" version="1">MKSSALWMAIGAILLLGGSVNAWGGLFNRFSPEMLANMGYGSHGGSYRPQSFLQNEILDEEQQSPRYEPDPCYPRGCSANEYCCPGFICVAVDDVRGMCMPLYGRKYGELCRHDSDCESGLVCDISALSGASVCRPPTIVAKQYGEDCITSSDCDITRGLCCQVQRRHRQVPRKVCSYFKDPLLCVGTVAADQVKHQIEHTAGEKRIIYNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZL8</accession>
    <name>A0A182NZL8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZL8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000099-RA">
        <property type="protein sequence ID" value="AEPI000099-PA"/>
        <property type="gene ID" value="AEPI000099"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000099"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000099-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="306" mass="31764" checksum="4881BD3A625B68E5" modified="2016-09-07" version="1">MVHAERLKDASQQPEAAALESQLVSAFRAAALPEGETLDLRQPSPLSPGADPHSHQHLHQQHHHQHPGAGPLPLPDYTRKRSHRHTDLPSFFQAAPGPGGATDLMPGPKKAKFSAAATAAAAAVAANYYDNAYLSFEKSLRGAFGGVDGMAGGGSLLDGAGGAGGGGNGGGSALDPYGGGHHLLSPINYTLTAEAINRRIRSTLGLDDQDPMERALALNNGSKGTPDECCPGMASPDWMLRRSGSGSASGPALAETRAYAHSPLPPGTPGTLYEEQKFAPFSPASSTNANTLHDDNNNVDKKAYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P003</accession>
    <name>A0A182P003_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KLRAQ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P003"/>
    <dbReference type="STRING" id="199890.A0A182P003"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000234-RA">
        <property type="protein sequence ID" value="AEPI000234-PA"/>
        <property type="gene ID" value="AEPI000234"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000234"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040024">
        <property type="entry name" value="PPP1R21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019343">
        <property type="entry name" value="PPP1R21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21448:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21448">
        <property type="entry name" value="SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10205">
        <property type="entry name" value="KLRAQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01254">
        <property type="entry name" value="KLRAQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein phosphatase 1 regulatory subunit 21 N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000234-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="215" mass="23931" checksum="775462C1E65741E0" modified="2016-09-07" version="1">MEAMEAENSNKYQKLATEYSKLRAQASVLKRAVLDEQNKSSSLRESLRLKEATLRKSEQEVDSLGFRNKQLERRVAALQENLEHELKKGSGGKALKTKSSNNDLNAVTGTEASVIAEELQKKILENAQLSNSVEDKSAEVKQLQNRIESLNRELQQQATVEQKLRKELELLTVRNSELESKVSEAASTVSGKLVAPCVPNHAMVFFLFCSDGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P048</accession>
    <name>A0A182P048_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P048"/>
    <dbReference type="STRING" id="199890.A0A182P048"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000280-RA">
        <property type="protein sequence ID" value="AEPI000280-PA"/>
        <property type="gene ID" value="AEPI000280"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000280"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000280-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="215" mass="21753" checksum="CFD511E51CF5DF99" modified="2016-09-07" version="1">MYGGGVLCPSPSTATGFYNPRGQGSEIGALELGFPRGMALVPPPPHGAWRDPSSLTGTHLPVASSTATAAGDDITTLGSQGPPGQTGSVVVPGMQTSSSSSSGGGGAQDKKDFISSSSGGSSIGSVGQHPSVTGAGSVGQGNGIEKKEFLSLQQSTTPGSQSMNSQNGQDLKNQNIECVVCGDKSSGKHYGQFTCEDSIELRRLACERAHDSQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0V7</accession>
    <name>A0A182P0V7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0V7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000539-RA">
        <property type="protein sequence ID" value="AEPI000539-PA"/>
        <property type="gene ID" value="AEPI000539"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000539"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="41"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000539-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="191" mass="21138" checksum="8EDBB1F27D0949B2" modified="2016-09-07" version="1">MPSTVIRMPAAAGGRHRNDQQQNRGLKIGCCRVCTCVNLAFFLSKNGILKCFELVLGWFCQTMLIQFGMDSAQDIGEAYWGFLTTCSACQLTTTILLLCYTISARTFHLVRQSIFEVVFNGLACVLYLSASSYLGFAVNVFLYPKFLLFKTTGGIHSAYPAMTAVYYMGGIVGMVYGVDTFVAYRHLKGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0Y8</accession>
    <name>A0A182P0Y8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0Y8"/>
    <dbReference type="STRING" id="199890.A0A182P0Y8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000570-RA">
        <property type="protein sequence ID" value="AEPI000570-PA"/>
        <property type="gene ID" value="AEPI000570"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000570"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12407">
        <property type="entry name" value="RRM_FOX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000375">
        <property type="entry name" value="RNA binding fox-1 homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034237">
        <property type="entry name" value="FOX1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047131">
        <property type="entry name" value="RBFOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597">
        <property type="entry name" value="ATAXIN 2-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597:SF22">
        <property type="entry name" value="RNA-BINDING FOX PROTEIN 1, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="194"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000570-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="277" mass="29286" checksum="49232AA567AD0A7A" modified="2016-09-07" version="1">MQQSEQEASNNVSSANTADATSVSSNNNSSSNTSSSSSTVNNNQTNAAVSAAIAAAVNSISSNTSPNSAINTSNSNNGTVNGSSSGSIVSSMVVTAAGPIGAGTTTVVSAIPPTMTSSASAVALAQQQQQQHHQQTLQAQLQQQQQQLNGQQTNQLQQQQQQQQQQVVVSSQPQQSQSVAAAVAALTDSKSQPKRLHVSNIPFRFRDPDLRTMFGQFGSILDVEIIFNERGSKGFGFVTFANSSDAERARERLHGTVVEGRKIEVCMKNKVFSFFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P109</accession>
    <name>A0A182P109_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CTLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P109"/>
    <dbReference type="STRING" id="199890.A0A182P109"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000591-RA">
        <property type="protein sequence ID" value="AEPI000591-PA"/>
        <property type="gene ID" value="AEPI000591"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000591"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057749">
        <property type="entry name" value="WDR47_COR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF11">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25602">
        <property type="entry name" value="WDR47_COR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000591-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="626" mass="67659" checksum="F1C87A0EACCCB330" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P111</accession>
    <name>A0A182P111_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P111"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000593-RA">
        <property type="protein sequence ID" value="AEPI000593-PA"/>
        <property type="gene ID" value="AEPI000593"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000593"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000593-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="227" mass="23412" checksum="37EBE34550767279" modified="2016-09-07" version="1">MVLTAATTSSSASAIVPAPMTRYDRALPVNAMTEKRYSDRRLRPWPPTYNYGIPGGGGVGGGPPNGSALMTMTTGGKSRWMSAGLSDIGSSLGGGGGGGMRGSSAGSIYGGSVGGGVPQPRYLYAPPGGALKRQNSDFFLNVKSASALAAGMGYDYNNNNSNGGSSSNYVVNNIAARKVKNIAGMTAIVDSDSNMEVVRRMRYKKRGGSGKRREKGGDGGAEIRRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P122</accession>
    <name>A0A182P122_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P122"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000604-RA">
        <property type="protein sequence ID" value="AEPI000604-PA"/>
        <property type="gene ID" value="AEPI000604"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000604"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000604-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="106" mass="11537" checksum="4031C6FB0BB31D3F" modified="2016-09-07" version="1">MVTVIDGLVNATRGPVGFAEVGSSWLPLPNQSRVASGGLDAADAIMEDSLDLLFVTLVFFIYLVQIVRFLTLPLRDRLEQRDEAQRLKRICMIVVKAILSSSAGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P152</accession>
    <name>A0A182P152_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P152"/>
    <dbReference type="STRING" id="199890.A0A182P152"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000634-RA">
        <property type="protein sequence ID" value="AEPI000634-PA"/>
        <property type="gene ID" value="AEPI000634"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000634"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001564">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF57">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="31"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="122"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000634-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="215" mass="23598" checksum="8F09A10348674BEB" modified="2016-09-07" version="1">MGKYECVAENSIGTEHTKPTPLYVKVRRVPPTFSRPPEPVYEVMLGANLTLTCVAVGSPMPSVKWRKGVDQDLTPENDVPVGRNVLELIDIRVSTNYTCIAQSSLGVIEATSLVKVQSLPAAPTDVTISEVTATQVRLEWSYKGPEDLQYYVIQYKPKNANQASIAFSEISGIITMFYVVRTLSPYTEYEFYVIAVNNIGRGPPSSPATTTTGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1E8</accession>
    <name>A0A182P1E8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Guanine nucleotide-binding protein G(s) subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Adenylate cyclase-stimulating G alpha protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the G-alpha family. G(s) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1E8"/>
    <dbReference type="SMR" id="A0A182P1E8"/>
    <dbReference type="STRING" id="199890.A0A182P1E8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000730-RA">
        <property type="protein sequence ID" value="AEPI000730-PA"/>
        <property type="gene ID" value="AEPI000730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000730"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000003">
        <property type="entry name" value="Guanine nucleotide-binding protein G(S) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:006178">
        <property type="entry name" value="Guanine nucleotide-binding protein G(s) subunit alpha isoforms short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000367">
        <property type="entry name" value="Gprotein_alpha_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF212">
        <property type="entry name" value="G PROTEIN ALPHA S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00443">
        <property type="entry name" value="GPROTEINAS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="54"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="187"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="212"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="281"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000730-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="383" mass="44701" checksum="56B4EB68F20DE0FB" modified="2016-09-07" version="1">MGCFGSAGSKQSDSNSSEDTKSQKRRSDAITRQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFSDSERKQKIEDIKKNIRDAILTITGAMSTLTPPIQLEKPENQARVDYIQDYASGPDFNYPPEFYEHTEELWKDRGVQQTYERSNEYQLIDCAKYFLDRVSEIKQPNYTPTEQDILRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWNNRWLRTISVILFLNKQDLLAEKIKAGKSKLSDYFGEFNRYQTPADAVCEMGEDPEVIRAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1W8</accession>
    <name>A0A182P1W8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">trypsin</fullName>
            <ecNumber evidence="12">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A182P1W8"/>
    <dbReference type="STRING" id="199890.A0A182P1W8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000902-RA">
        <property type="protein sequence ID" value="AEPI000902-PA"/>
        <property type="gene ID" value="AEPI000902"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000902"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF97">
        <property type="entry name" value="GH13245P2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0222">Digestion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="213"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000902-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="395" mass="43979" checksum="9B72CF891FE9BD26" modified="2016-09-07" version="1">MVSVQRWKPNASSHICGGTFISDRWILTAGHCVDDGEFIQGGIVRVESSFHASGGFFLTIERTVRHESIAYGSVGIDYDYGLIKLATRFERAVPVRLVADGRRFRAGELCTIIGWGMTKNTGDREQLRMVRVPIVRQQECREVYSELHSITRRMICAGYPAGGQDACEGDSGGPLLCRGIQVGITSWGLGCAKPKRYGVYSNIANQREWIRKHTGVKISSTTVMVRANSSFFNRGGKLHRVEKVIKHELFSYATGDYDFGLLKLKQRFRRGRFVKLPSRRRRFPPGERCTAMGWGQTLGPESRDQLREVVLPIVSQRVCRKAYEGTDEITARMLCAGYPEGMRDACDGDSGGPLICRGIQAGVISWAIGCAQPNKYGVYSSIAQGLDWIRNHTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2M8</accession>
    <name>A0A182P2M8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide. Man(5)GlcNAc(2)-PP-dolichol is a substrate for ALG3, the following enzyme in the biosynthetic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="4 14"/>
    <dbReference type="AlphaFoldDB" id="A0A182P2M8"/>
    <dbReference type="STRING" id="199890.A0A182P2M8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001162-RA">
        <property type="protein sequence ID" value="AEPI001162-PA"/>
        <property type="gene ID" value="AEPI001162"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001162"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000227">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="16">
        <location>
            <begin position="47"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="15">
        <location>
            <begin position="280"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001162-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="478" mass="55226" checksum="B4BD1805FD0E2842" modified="2016-09-07" version="1">MFCWSCFVYVLFFLGSFLAIGLLTVCVLLRQIIKFQRRKRTDPTVKHVAFFHPYCNAGGGGERVLWCAIRALLARYENIKLFVYTGDLEAKPEDILAKAERSFNLALEADRITFVYLSKRCWVEASRYPHFTLLGQSLGSIVLAFEALLKLQPDVFIDTMGYAFTYPVFSYFGGCKIGCYTHYPTISTDMLRRVQSQSQSYNNRGYVAKNPFATWLKIVYYRLFSRIYGWVGRCADTVMVNSSWTENHIISLWDVPYKTHRVYPPCEVSQLKRLESLTDERDEHIIILSVGQYRPEKDHPLQLQAMYELRTLLNNDEALWNRLKLLIVGSCRDEEDRVRVKNMQDLAKHLSLENSVEFRVNVPYRELLECYQRATIGLHCMWNEHFGISVVDCMAAGLIMVANRSGGPLMDIIETSEGSQNGYLAFDAYDYARCIANILYNTPEYNARIREAARASVDRFSEKEFENGFLRAISPIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P321</accession>
    <name>A0A182P321_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P321"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001309-RA">
        <property type="protein sequence ID" value="AEPI001309-PA"/>
        <property type="gene ID" value="AEPI001309"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001309"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028928">
        <property type="entry name" value="CC2D2AN-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056288">
        <property type="entry name" value="CEP76_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052434">
        <property type="entry name" value="Tectonic-like_complex_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837">
        <property type="entry name" value="CENTROSOMAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837:SF0">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15625">
        <property type="entry name" value="CC2D2AN-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24652">
        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="867"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001309-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1454" mass="167438" checksum="5A685272B7B18AF7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3B7</accession>
    <name>A0A182P3B7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">CSN12-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3B7"/>
    <dbReference type="STRING" id="199890.A0A182P3B7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001402-RA">
        <property type="protein sequence ID" value="AEPI001402-PA"/>
        <property type="gene ID" value="AEPI001402"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001402"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000146">
        <property type="entry name" value="PCI domain-containing protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="207"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001402-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="395" mass="46058" checksum="A1481978AEF7EC32" modified="2016-09-07" version="1">MYLHDYLNKIMRVWNAYEGQAVARFLSLQDFHVNDPNLYKENPDAAVSRQLPSPLDEIVSAHLKVVYHLMRSEPPNYTEAYRYQTSCIQAVVKLLQQMKEENWILPIMYVVSIDLRILAAKCEQQTKSSKCGEILEKAAESLMSCFRVCAGDTRSSDEDTKRLGMLNLVNQLLKVYFRINKLHLCKPLIRAIDSSNFKDSFSLAQRITYKYFAGRKAMYDSDFKNAEEYLSFAFNNCPRRFTKNKRLILIYLTPVKMLLGYMPRKEVLERYNVLQFHDLASAVKEGNVRRFDEAIRRHEMFFINAGVYLIVEKMKILTYRNLFKKVHQILQTHQIDMNAFQTALQFSGAEDVSMDETHCIVANLIYEGRIKGYISYQHNKLVISKQNAFPNVVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3U6</accession>
    <name>A0A182P3U6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">BIR repeat-containing ubiquitin-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Baculoviral IAP repeat-containing protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Ubiquitin-conjugating BIR domain enzyme apollon</fullName>
        </alternativeName>
    </protein>
    <organism evidence="32 33">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="32">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
            <location evidence="4">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the BIRC6 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P3U6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001582-RA">
        <property type="protein sequence ID" value="AEPI001582-PA"/>
        <property type="gene ID" value="AEPI001582"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001582"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <sequence length="5443" mass="589214" checksum="1CD0A2D762F5BC5E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P414</accession>
    <name>A0A182P414_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA topoisomerase</fullName>
            <ecNumber evidence="3 8">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Weakly relaxes negative supercoils and displays a distinct preference for binding single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
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        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd00186">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056452">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23546">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="11">
        <location>
            <begin position="169"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="819"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="819"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001650-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="857" mass="96179" checksum="E0AD17C0F2E6B990" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4J9</accession>
    <name>A0A182P4J9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ-loop repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4J9"/>
    <dbReference type="STRING" id="199890.A0A182P4J9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001835-RA">
        <property type="protein sequence ID" value="AEPI001835-PA"/>
        <property type="gene ID" value="AEPI001835"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001835"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001835-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7673" checksum="E2818E027F7B9295" modified="2016-09-07" version="1">MDWIINDELGLTVGHLVGWTSASFMVVGGVLPYIPQYRQIKQTQDPEGFSLHVCLALLVANTLRILFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5C5</accession>
    <name>A0A182P5C5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5C5"/>
    <dbReference type="STRING" id="199890.A0A182P5C5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002115-RA">
        <property type="protein sequence ID" value="AEPI002115-PA"/>
        <property type="gene ID" value="AEPI002115"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002115"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF13">
        <property type="entry name" value="LD14533P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002115-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37901" checksum="33D16CBDF2475093" modified="2016-09-07" version="1">MDRVKLCDQILLQKLHLLSNEVLRTNRGITERDMEEAFKQSIGYRAPRFFPQNDGILAIVYSAIFVVVLFIITPFLASFLELALGMRCIVPNNYLIWEATRPVSNCDFCRGVDRPIILPNLTREEFQPYAYSSRPIIIKRAVSHWPAVRLLNYTFLKDLYLKHPAALDSLHEDCQFLHFKSNFQTLRDVFRMSDERAEFRAGQQPWYVGWSNCNPAVLGELRKLYPKPHFLPDDAEMPNTDFVFLGYEQGAVMHIDYIPRLMWQAQLRGNKSWILAPTPECDAECRSFSFYVEPGDALLVDTRLWYHGTFIHSKGEFSLTIQSEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5I7</accession>
    <name>A0A182P5I7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A182P5I7"/>
    <dbReference type="STRING" id="199890.A0A182P5I7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002177-RA">
        <property type="protein sequence ID" value="AEPI002177-PA"/>
        <property type="gene ID" value="AEPI002177"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002177"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF3">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="616"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002177-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="696" mass="78450" checksum="984680FCD2A74CF3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5V1</accession>
    <name>A0A182P5V1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5V1"/>
    <dbReference type="STRING" id="199890.A0A182P5V1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002292-RA">
        <property type="protein sequence ID" value="AEPI002292-PA"/>
        <property type="gene ID" value="AEPI002292"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002292"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003287">
        <property type="entry name" value="Zgc:113343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002292-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="559" mass="64050" checksum="2FA4C3B45EE5DB95" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5V4</accession>
    <name>A0A182P5V4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="199890.A0A182P5V4"/>
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        <property type="project" value="TreeGrafter"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF09335"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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</entry>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P681"/>
    <dbReference type="STRING" id="199890.A0A182P681"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002429-RA">
        <property type="protein sequence ID" value="AEPI002429-PA"/>
        <property type="gene ID" value="AEPI002429"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002429"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992:SF9">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002429-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="80015" checksum="B290853921598209" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7D5</accession>
    <name>A0A182P7D5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
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                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
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        <property type="gene ID" value="AEPI002837"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
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    <proteinExistence type="predicted"/>
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            <end position="189"/>
        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="940" mass="104226" checksum="C006BD3C57D7468D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7I0</accession>
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        <alternativeName>
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        </alternativeName>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB4 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7I0"/>
    <dbReference type="STRING" id="199890.A0A182P7I0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002882-RA">
        <property type="protein sequence ID" value="AEPI002882-PA"/>
        <property type="gene ID" value="AEPI002882"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002882"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009866">
        <property type="entry name" value="NADH_UbQ_OxRdtase_NDUFB4_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B15 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07225">
        <property type="entry name" value="NDUF_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002882-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="105" mass="12462" checksum="6201CB5A78633CCB" modified="2016-09-07" version="1">MSQQEKAARRAALRNEYWRTMTNPHNHLRGESGGVFDTGLARFQAMRVNHYEHFKPTGRSFKIGLFTVVIPIIVYAKMMKNERDQREHQYRTGQVAYADRRFKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P855</accession>
    <name>A0A182P855_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P855"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003108-RA">
        <property type="protein sequence ID" value="AEPI003108-PA"/>
        <property type="gene ID" value="AEPI003108"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003108"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003108-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="141" mass="15449" checksum="A5B3CE6682E84DEC" modified="2016-09-07" version="1">MKLQQCVIDFAIVLITIPSLVVVALLLDTMMNRTGWSEQLETQLIMAALAVAFFLICIMISVYLTHRVGNCLWAGPQPDQQSICSIERGLAIAPPPSYETVMSEQAHPPSYEKISKIFPPQEPPPSYAATVALGRDVAAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8L3</accession>
    <name>A0A182P8L3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanine nucleotide-binding protein-like 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Possible regulatory or functional link with the histocompatibility cluster.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8L3"/>
    <dbReference type="STRING" id="199890.A0A182P8L3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003266-RA">
        <property type="protein sequence ID" value="AEPI003266-PA"/>
        <property type="gene ID" value="AEPI003266"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003266"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF3">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="178"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003266-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="594" mass="68346" checksum="80BA5D15A2F856F5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P972</accession>
    <name>A0A182P972_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein FRG1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P972"/>
    <dbReference type="STRING" id="199890.A0A182P972"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003476-RA">
        <property type="protein sequence ID" value="AEPI003476-PA"/>
        <property type="gene ID" value="AEPI003476"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003476"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23338">
        <property type="entry name" value="beta-trefoil_FSCN_FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000061">
        <property type="entry name" value="Protein FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003476-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="262" mass="29061" checksum="2BAFE7E07345FF8D" modified="2016-09-07" version="1">MSEYSKAKVSKLVLKGESSKGTKRKHKKDKKNKEAKRALVVDADAVKHGGWWMVTKTSDITGSIALQFDKQAYVKALDNGLFTLGAPHNEGDPPDPEEIFSAVLINEQKVAFKSGYGKYLKVEKDGMITGRSDAVSALEQFEPVFEQGKTALLAANGCFVSVDPEDDALVAIKKKVGSDEVCMIRSCAGREDISNKELPVEESGDLDQVELNYVKKFQKFQDKKIRVSKEDKLALKKAKDDGALHEALLDRRSKMKADRYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9H2</accession>
    <name>A0A182P9H2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P9H2"/>
    <dbReference type="STRING" id="199890.A0A182P9H2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003577-RA">
        <property type="protein sequence ID" value="AEPI003577-PA"/>
        <property type="gene ID" value="AEPI003577"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003577"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF130">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="126"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003577-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="394" mass="45730" checksum="7DC59F104BEE112D" modified="2016-09-07" version="1">MSSNDSTPLNSPRKIFGKTATLDNNAMLEYEMNKNLDVTFREKAEKELGETGGELTYTKIRQLRQQLNIYNENHQRALGCRRDDSFLLRFLRAKKFDVEKAFKMMQKYYKMKEEYPEIFKVSPPSEMKFMLEMQIQTMLPKKDEHGRQIYLFRVEKCDPYKIPVDYVFRSNVLALEDAVRSPETQIGGLVVLLDMAGLGFAHARYLSPHLAKKTVEVVQEAFPLRFKAFHVLHEPFYFDAILAVLKPFLKDKIRRRIHLHGNSLSSLHKYISKDLLPVEYGGNLGPFDNTEWRQTILDNEQYFIDLETYNHLSESCYQLGGGDGDAESIDSLQFGDTETEDSEFDEDDRRVLSPKRNARSIQNIEEIFLKNGYDGMAPEVASVPDMEKEVEELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9S5</accession>
    <name>A0A182P9S5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-uridine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TDD superfamily. DTWD2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182P9S5"/>
    <dbReference type="STRING" id="199890.A0A182P9S5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003679-RA">
        <property type="protein sequence ID" value="AEPI003679-PA"/>
        <property type="gene ID" value="AEPI003679"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003679"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039262">
        <property type="entry name" value="DTWD2/TAPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392:SF0">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="7">
        <location>
            <begin position="24"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003679-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="263" mass="29581" checksum="5A233C5FF86777CE" modified="2016-09-07" version="1">MSEVMLETSAWEDLANIPADPPRMRPLCVKCCRPVQVCWCSALPPEPLSPAGRIVLLQHPAEEKRSLRTAPMLSVGLAPGKCLIYKGKRFPRHDQELETILADKRSLLLYPSANSVPIEQIDPSEGPYNLILIDGTWPQAKAIYHSSTALHGMRQVKLVSSGTSSYIIRTQPTEGCLSTLETAIEALSVLERDNRYREQLLQPLHVLCQYQLANGAVTHQSKEFLIRHNQYPKLIGRRLNRLLKHADNFKDEPMDAAERINST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA51</accession>
    <name>A0A182PA51_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PA51"/>
    <dbReference type="STRING" id="199890.A0A182PA51"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003805-RA">
        <property type="protein sequence ID" value="AEPI003805-PA"/>
        <property type="gene ID" value="AEPI003805"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003805"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003805-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="340" mass="37041" checksum="37B7177A706842BD" modified="2016-09-07" version="1">MSYIGPDPASLAEEWPTEEALDLLSNNVAGETDVQLYSGGSSKLPRSSGDDHRFARQTELTDEDSGIISGRASIQAITKVDVGVNSQLIGARGQALQLYFEVTNYRQTPITYFFRVTDELAFLRSLNPGQVTLNPGASVLVTVALVVTPTAEIGSRDKVTFSTTGVDTVSQSAWVTVSDSAGLADSTRPSLWYTYSSRCEGRSTPATCTGAFWTLEVMARDWETGLMRISSSPAGLLYKTPFTAGTRDEVRASYTASCCQPRVTVTAYDVSRNVRSLNLDVTDIWLNDAGIAAVVLGVLLFIALIILLVLLIRYCIRKRRQSKELPIYRGGEPIGSRRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAN8</accession>
    <name>A0A182PAN8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAN8"/>
    <dbReference type="STRING" id="199890.A0A182PAN8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003993-RA">
        <property type="protein sequence ID" value="AEPI003993-PA"/>
        <property type="gene ID" value="AEPI003993"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003993"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="355"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003993-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="413" mass="45666" checksum="F101D9AA66DD73E1" modified="2016-09-07" version="1">MEEKHHSDAPRAEVEDQFQCKTDGCKQTVPTDGYCTLHSKKHDLSLNLQMPQKTTGGGLLFADQTPTPTRLIGKCEEVGLFEDLQKVNPFDETFRRAVESGASSVCSSDDQSPLIPSFSVPCCRAVEGETLHTPHIFPSGIDRSSLLDGIASGSEKNAAAKQQKPKNKASGSSPRGKQQQQQPQPQQTQPQQTQPQQTQPQSQQQQQLQAKQVEQPPKSTMATNSTTPTNKPKSVKKTPAKRKTPAAAVEILPKPSTTQSSLITDEPIPLIIIPPDHVPDTTLPAEGIVLVKKKLKEHLAKVRETGPLQKESAPAVKKAKRSEQKPDTSNKVTKPTDLPDALNERAILKQERWKAAAKRYRMRLKISQDQQLQRNIELEAENHRLRTQLAEMKAAHRNCNVTCSSKLVQVNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAR5</accession>
    <name>A0A182PAR5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAR5"/>
    <dbReference type="STRING" id="199890.A0A182PAR5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004020-RA">
        <property type="protein sequence ID" value="AEPI004020-PA"/>
        <property type="gene ID" value="AEPI004020"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004020"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004020-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="169" mass="17521" checksum="17DAA5CC0D385F01" modified="2016-09-07" version="1">MTPLAQAPVAGAPVETTTVNPNAKQYIPPPGQYYPATGQYVPPGEYDPATGIFTPGRYIPDTSIFQSGQYDPLTQMFTPGRYEANGQFVPDPNHPPLSLAPPNDGSTAGQTAAVTPAAAAVQSAQSEPVATPAVASLKTTSGGSMKTVSLLTALGALIVSESFRQIVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB32</accession>
    <name>A0A182PB32_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PB32"/>
    <dbReference type="STRING" id="199890.A0A182PB32"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004137-RA">
        <property type="protein sequence ID" value="AEPI004137-PA"/>
        <property type="gene ID" value="AEPI004137"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004137"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001579">
        <property type="entry name" value="Crooked legs, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000253">
        <property type="entry name" value="Crooked legs, isoform H"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000151">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="632"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="716"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="772"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="801"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="833"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="861"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="929"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="971"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="986"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1035"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004137-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1116" mass="128344" checksum="94020648A13A01A0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB57</accession>
    <name>A0A182PB57_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import receptor subunit TOM22 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PB57"/>
    <dbReference type="STRING" id="199890.A0A182PB57"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004162-RA">
        <property type="protein sequence ID" value="AEPI004162-PA"/>
        <property type="gene ID" value="AEPI004162"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004162"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004162-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="223" mass="23278" checksum="BFD8765A377C7667" modified="2016-09-07" version="1">MDSDPEVVLVEKIEEDEISTDKDSGMESAIGSKDETPERKPSTPEEAPKQDEPVKPAATAASETAPSAPASSSSSTAAPAPAAAPSGPSTSSRTSATTPPQPNKTVARTSANDYDDEPDETLGERLWGLTEMFPEPVRQLSGAVTDLTVRSVKGLYSLTCNASWIFFTSSMILLAPVVFEVERAQMEEMQKSQQKQVLLGPGSAVGGGAPGGMPALPPMASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBS9</accession>
    <name>A0A182PBS9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-spondin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBS9"/>
    <dbReference type="STRING" id="199890.A0A182PBS9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004385-RA">
        <property type="protein sequence ID" value="AEPI004385-PA"/>
        <property type="gene ID" value="AEPI004385"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004385"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000161">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000154">
        <property type="entry name" value="GD10853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000172">
        <property type="entry name" value="Putative reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2130:FF:000002">
        <property type="entry name" value="Putative Spondin-1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF16">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131219" description="Spondin-1" evidence="13">
        <location>
            <begin position="36"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="15">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="16">
        <location>
            <begin position="199"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="680"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004385-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="892" mass="100802" checksum="CFF4FCB0866FFA17" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC14</accession>
    <name>A0A182PC14_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UNC93-like protein MFSD11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC14"/>
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        <property type="gene ID" value="AEPI004470"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004470"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF0">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004470-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="397" mass="42331" checksum="8BC96A93202CDFCE" modified="2016-09-07" version="1">MVERNLVNVLLLGGGFMLIFTSFQTLGNIEQTIIDSIKKDLPSFTGDGYTSLAIIYAALSLSNWVTPSVLSAIGPRLAMAIGAITYCLFMASFFVPHVALLYGCSVVLGAGAALIWTGQGMYLSQCSTGETISRNSGIFWAMLQMSMFFGNLLVFFTFQGKTHIDETTRSIVFAVLIAVAIVGLILLSCLRRPATNGDVPVELSESVRPREAFLSLSLSFFSGVYGSSIGFTNAIGTSAKQYVGLNGVFIGVGEVLGGVAFGLLGTRTTTRWGRDPIVIAGGVLHMAAYFLIYLNLPNGAPFGSTDEVAYIHPPSALIAMACSFLLGLGDACFNTQCYSMLGGSVAAAASFVYSSYCGLHVQLIILVLLGITGTVTFCVVEFAVKRERPALERDYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCK1</accession>
    <name>A0A182PCK1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCK1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004656-RA">
        <property type="protein sequence ID" value="AEPI004656-PA"/>
        <property type="gene ID" value="AEPI004656"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004656"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004656-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="109" mass="10829" checksum="A544B66F3D340B4E" modified="2016-09-07" version="1">MLCFVQGIASMNHGGSSSNSSNNPPMVRSNSKLGSSEASSTSSASSSSPAGKRLSATSVGLGTRPLPLSSTIEPLSSVESSGGGQPEGTAHLNVLSRSPSHSTAKSDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCM9</accession>
    <name>A0A182PCM9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCM9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004684-RA">
        <property type="protein sequence ID" value="AEPI004684-PA"/>
        <property type="gene ID" value="AEPI004684"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004684"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004684-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="136" mass="14530" checksum="CF2E3957250EE519" modified="2016-09-07" version="1">ASAHDLSTHTRGPLRLEDRLSIPSEAQELEFSLAPDIDLTGTQRDETGKMGPVDKRTPVGRLVGVTMCLVLLTASVVQTGPVIRSRRMIREIYVENSAASPMAQENASSEIPSSTSGNSNGKSLAVRLSSTEHCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDF9</accession>
    <name>A0A182PDF9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PDF9"/>
    <dbReference type="STRING" id="199890.A0A182PDF9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004964-RA">
        <property type="protein sequence ID" value="AEPI004964-PA"/>
        <property type="gene ID" value="AEPI004964"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004964"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008586">
        <property type="term" value="P:imaginal disc-derived wing vein morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045746">
        <property type="term" value="P:negative regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04021">
        <property type="entry name" value="C2_E3_ubiquitin_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000084">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000221">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase HACE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF429">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SU(DX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="562"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="656"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8 9">
        <location>
            <position position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004964-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="990" mass="111465" checksum="A9F68E485658640A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDS5</accession>
    <name>A0A182PDS5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF667 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDS5"/>
    <dbReference type="STRING" id="199890.A0A182PDS5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005080-RA">
        <property type="protein sequence ID" value="AEPI005080-PA"/>
        <property type="gene ID" value="AEPI005080"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005080"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005080-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="242" mass="27639" checksum="4F1B81BCDEEBFB85" modified="2016-09-07" version="1">MFRNAFQHRFVTVFSSAGSKPLAIWDVHTKNGHARRVTDEDIRSLAFELTGVNVATTYMVAPCAPCPSLSIKLPFLVMLVKNMKKYFCFEVQVLDDRQSLRRLRFSNYQSGSRVDNFSSCMPLSLTCNWNHIQLNLAEFIRRAYGTNYVETVRLQIHANVRVKRIYFCDRLYTNDETPAELRLFAPVRPNRMVQLKAQQKAAKIPHEPIETVRPPTPVDASDITNLLENELASTQCIVAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDT3</accession>
    <name>A0A182PDT3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDT3"/>
    <dbReference type="STRING" id="199890.A0A182PDT3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005088-RA">
        <property type="protein sequence ID" value="AEPI005088-PA"/>
        <property type="gene ID" value="AEPI005088"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005088"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008020">
        <property type="term" value="F:G protein-coupled photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00577">
        <property type="entry name" value="OPSINRH3RH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="13 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="15 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="72"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005088-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="379" mass="42326" checksum="C4C872C4CDE814D5" modified="2016-09-07" version="1">MGLVQLDNQTAYRPEALIGADQSGLRYLGWNVPPEELVHIPEHWLQFPEPEASLHYLLGLLYIAFTIFSLVGNGLVIWIFIAAKSLRTPSNVFVINLAICDFFMMAKTPIFIYNSFTKGFTLGNLGCQIFGFVGSLTGIGAGATNALIAYDRYNTITRPFEGRLTQTKAIIFICLIWAYTIPWGVLPLLEIWGRFVPEGFLTSCTFDYLSGTFDTRLFVGSIFTFSYVLPMSLIIYYYSQIVSHVVNHEKSLRDQAKKMNVESLRSNQTQKDASVEIRIAKAAITVCFLFVASWTPYAVLALIGAFGDKSLLTPGVTMFPACACKFVACLDPYVYAISHPRYRIELQKRLPWLAITETLPAENASTCTEQQDGNATTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDY6</accession>
    <name>A0A182PDY6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDY6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005141-RA">
        <property type="protein sequence ID" value="AEPI005141-PA"/>
        <property type="gene ID" value="AEPI005141"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005141"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005141-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="190" mass="20709" checksum="33C6DA26EB8846A9" modified="2016-09-07" version="1">MDKTVKLKSGSASSLSLLELSNSNEDVIQQRINSIRMELDDTYNIFVSAQETLSSISFEHLSERLGTNDDCSSPSVEAIGTSPSESSPLVHDANDRVDVAKSLEQLNAVPKQAQRTKSAEDIPELSAFFKVIQDLTEGIKKISSHQQSITELNQDINTFGERTSSGAQKSSDSHSSLTSLSNRMATMNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE86</accession>
    <name>A0A182PE86_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="18">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="16">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A182PE86"/>
    <dbReference type="STRING" id="199890.A0A182PE86"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005241-RA">
        <property type="protein sequence ID" value="AEPI005241-PA"/>
        <property type="gene ID" value="AEPI005241"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005241"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02173">
        <property type="entry name" value="ECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase S1" evidence="21">
        <location>
            <begin position="492"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005241-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="751" mass="83090" checksum="2BCF7220FA575611" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PET1</accession>
    <name>A0A182PET1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PET1"/>
    <dbReference type="STRING" id="199890.A0A182PET1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005436-RA">
        <property type="protein sequence ID" value="AEPI005436-PA"/>
        <property type="gene ID" value="AEPI005436"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005436"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF50">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131206" description="Peptidase S1 domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="29"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005436-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="261" mass="27957" checksum="D51B8944E82F28C8" modified="2016-09-07" version="1">MQSATMIALLAVASYAFVAQAAPQGGMRVVNGETAALGQFPYQVRLTLKVGNGQQALCGGSLLNEEWVLTAAHCVMLAKSVEVHLGAVDFNDETNDGRLVLESTEFFKHSRYNPLVVANDVALVKLPEKVQFSERVQPVRLPTGNEDFVGQSVVVSGWGLMVNGGQVAQELQYATLKVITNSECQKTFSPLVVRKSTLCARGEELRSPCNGDSGGPLVLAEDKTLVGVVSFGHAQGCDKGHPAAFARVTAFRDWVKKHTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH40</accession>
    <name>A0A182PH40_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PH40"/>
    <dbReference type="STRING" id="199890.A0A182PH40"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006249-RA">
        <property type="protein sequence ID" value="AEPI006249-PA"/>
        <property type="gene ID" value="AEPI006249"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006249"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF7">
        <property type="entry name" value="RE59626P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="41"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006249-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="233" mass="26325" checksum="EFA6395EADBE04C2" modified="2016-09-07" version="1">MLKQKRVFYKERLIQSLFEQDLGDQFKIDASTQGLQKVNLRCGADSMRIELKTEEDFQGVMYTRGSYYKQTQPCFVKPERAGRTLEMKFNLDQCQTVNNGEVYSNIVVVQHDPDIVTPGDAAFAVECDFRKPRGVTVSSEIQARDSEAAATSPSSRITLTSPDPSANTQTPNEHNSVHSESGTVTFVPSRFRNASHQLPEQRVRGTVETVQIPLHTTQQEQQQEHHDANHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHB0</accession>
    <name>A0A182PHB0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26C</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the heterotrimeric retriever complex consisting of VPS26C, VPS29 and VPS35L; within the complex interacts with VPS35L. Interacts with SNX17 (via C-terminus); the interaction is direct and associates SNX17 with the retriever complex. Interacts with SNX31; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHB0"/>
    <dbReference type="STRING" id="199890.A0A182PHB0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006319-RA">
        <property type="protein sequence ID" value="AEPI006319-PA"/>
        <property type="gene ID" value="AEPI006319"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006319"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000009">
        <property type="entry name" value="Down syndrome critical region protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000024">
        <property type="entry name" value="Down syndrome critical region protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006319-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="552" mass="63157" checksum="FA0D27E3091AA3EE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHG7</accession>
    <name>A0A182PHG7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHG7"/>
    <dbReference type="STRING" id="199890.A0A182PHG7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006376-RA">
        <property type="protein sequence ID" value="AEPI006376-PA"/>
        <property type="gene ID" value="AEPI006376"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006376"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052085">
        <property type="entry name" value="WD-SAM-U-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573:SF1">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="365"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="4">
        <location>
            <begin position="424"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006376-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="503" mass="55552" checksum="1FDE95403D7F2DAC" modified="2016-09-07" version="1">MSAAKTTILQKLTAHTSDVTSLDFYGNALLVTGSSDKTVRVWRWVAGSGYREEPFSPLLGHRYGVTSVRVSPKGAVLASASVDGTVILWNLSNGEISNVLNQEGGEAIRACIFSPNGSTIVSSDDSGSVCIWGQDKTLKWYVCFWSMLSKSSFPYMSVYILSSHVKVHDEAVHTIAFSSDSDILLTACTLGNVRLYAVENDFAGNSNHALLFKELHRKCFTLSLGDLSSADCSIDAAHDMGVLSADFCKIVHTDPTDKCSLIYTVATCGTDHYIKIWRIFFMPNNIDRSRRRSRLIPTSPQEHFAGQSTIYSTEVMNASCVQTISAHGSSVTCVRFNPTGTLLFSCSLDKNIKIWNQQGTCLKTLSEHLRYVNCLAINSDSSVVASGSNDRTIVVWDLTSRLSTSSHITGIRSLLFSLAMKTSEIPLEFTCPITHELMKDPVYAEDGFTYERSAIREWFSREKTISPMTNLELSTDELVENGKLKQQIEDYMRSLDVEAGDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI90</accession>
    <name>A0A182PI90_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Piwi</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the argonaute family. Piwi subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PI90"/>
    <dbReference type="STRING" id="199890.A0A182PI90"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006652-RA">
        <property type="protein sequence ID" value="AEPI006652-PA"/>
        <property type="gene ID" value="AEPI006652"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006652"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02845">
        <property type="entry name" value="PAZ_piwi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04658">
        <property type="entry name" value="Piwi_piwi-like_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000003">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23278">
        <property type="entry name" value="Piwi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="PAZ" evidence="8">
        <location>
            <begin position="274"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="9">
        <location>
            <begin position="550"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006652-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="863" mass="97850" checksum="6F31EE941EB0D39A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIB5</accession>
    <name>A0A182PIB5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIB5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006677-RA">
        <property type="protein sequence ID" value="AEPI006677-PA"/>
        <property type="gene ID" value="AEPI006677"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006677"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398:SF21">
        <property type="entry name" value="AGAP004005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131479" evidence="1">
        <location>
            <begin position="26"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006677-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="273" mass="29777" checksum="D647A5AEAAD9591D" modified="2016-09-07" version="1">MFTATSPVHWAVLATLGYLTAVSIASGSSEEGKPRQKRFLIFPRANPQRLQLIGGFGIPADIQLESITMGYVFKSVYLLPWNSSHWIPPFLDRHEFETGRRALRRRNVPPIVPLVLAPSNAEPYERYDGRWQELDREPLPAPEQATGSGASSPQHSRWLFYHMLEQLLEQKGLPGRVCVLRAICEASEATFTHTSGLIGELLHIAFTPSATEDGAGQGLHQALLYGQAEKLPATMSAKSGRSVCADVYAECALSLLGSFTDVFGADGSDGPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PID5</accession>
    <name>A0A182PID5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PID5"/>
    <dbReference type="STRING" id="199890.A0A182PID5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006697-RA">
        <property type="protein sequence ID" value="AEPI006697-PA"/>
        <property type="gene ID" value="AEPI006697"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006697"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131344" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="41"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="183"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="266"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006697-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="329" mass="36514" checksum="C6FC1BA5E0898DCC" modified="2016-09-07" version="1">MTSGLRPILILLALGTLASASVVRKSCLSCGYPTGHQIPSHSFCLQTDLRTYFRHEHECGKFYRCNRGTAYEFLCSEGYGFNEEANACEHIAKFLCSEGYGFNEEANACEHIAKVRCPTDISYASNTHELEHDFVRASGAGQRNRTGNTHELEYDFVRASGAGQRNKTSCNICQSAVHLVRNHPNCPTRNGYYPVMFRHQSDCSKYYLCDHGTAYEIACPGGLHFNTALNVCDYPESVGCSAVAEDSDVAVEKPTEEGEQSVPKVHPNCPAVTGRQEPAYWPHPHDCGKYFGCQWGCVELLSCPAGYRWDDGKKACSLKKSVECDNAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PID6</accession>
    <name>A0A182PID6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PID6"/>
    <dbReference type="STRING" id="199890.A0A182PID6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006698-RA">
        <property type="protein sequence ID" value="AEPI006698-PA"/>
        <property type="gene ID" value="AEPI006698"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006698"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006698-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="210" mass="21491" checksum="C293B9AC1E9325D5" modified="2016-09-07" version="1">METLAETSLPSGLRRTEPSSLIPTSPEGEQSPQNSNPGSVLANIIGTSPGGSSSAHNLLEDHSQSSQEDSGSVVSPVPHPEPEETIENIEKELSESCADTDSQSALEAGYGKQAATSPSGRARRGKTTTSSPPTSSSAGGKGEAKEQSVMTAASGTGAASVSNGGSLPKVAHAPSGGKPKAMRDFDRKMNKARGRPKSKGMVAMYQSQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIG3</accession>
    <name>A0A182PIG3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIG3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006725-RA">
        <property type="protein sequence ID" value="AEPI006725-PA"/>
        <property type="gene ID" value="AEPI006725"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006725"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41155">
        <property type="entry name" value="FI19525P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41155:SF1">
        <property type="entry name" value="FI19525P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006725-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="338" mass="37644" checksum="2B8A8E19A05223C6" modified="2016-09-07" version="1">VALALSRGCNLSFSPNIFVRAFLSSPLVDPTATVIMLKNIHERTVKKVKGNHYVATHGRDTVDLPYAQANRGYSTDGEDSQRAPSERTLSEYTVANERATPPTAPARKSRSEHKYQNNGGPRPLSSPPTRAPPRAPSALSYDHGGETGSDIYVTSAAYKAPSEISRYSAHRTHQSRGPRSVYSVASTAKTGRSSRRHGAKVEAMSAPNPFCPNVKGVCCLMLLLNLGLILITLGFVIVMQFMEPLFVWILGVVFLIFGFGTLIGSMIYCVIVCRDAKTPSQLKNEDLYWTKHWQKSIGYTPQEIDYKTDRFDERDRYSDRFSVSKMSGKYSDRDITRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJR6</accession>
    <name>A0A182PJR6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PJR6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007180-RA">
        <property type="protein sequence ID" value="AEPI007180-PA"/>
        <property type="gene ID" value="AEPI007180"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007180"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF37">
        <property type="entry name" value="GH25853P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="478"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007180-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1335" mass="148236" checksum="B413A77701F9ADCB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKA8</accession>
    <name>A0A182PKA8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mpv17-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKA8"/>
    <dbReference type="STRING" id="199890.A0A182PKA8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007374-RA">
        <property type="protein sequence ID" value="AEPI007374-PA"/>
        <property type="gene ID" value="AEPI007374"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007374"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF85">
        <property type="entry name" value="MPV17-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007374-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21108" checksum="AA04FDA117267776" modified="2016-09-07" version="1">MATFLRAFGRFFTKHPLAGNGLVYGTLYVGAEFSQQAITRKLLTDPPQDIDRPTLARYAVMGTFIYSPILYNWYKWLDKTFPGTAKRIIVKKLLLDQFVLTPPLLVIFFTGMSLMERQSSITEECRQKFLPTFARSCLFWIPAQTLNFVLVPPKFRVVYVGSCAFAWVNILCWVKRQKMLNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKR4</accession>
    <name>A0A182PKR4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKR4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007531-RA">
        <property type="protein sequence ID" value="AEPI007531-PA"/>
        <property type="gene ID" value="AEPI007531"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007531"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131404" evidence="3">
        <location>
            <begin position="23"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007531-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="238" mass="26170" checksum="A8F36BF38A31A797" modified="2016-09-07" version="1">MPLLTDIFIRILALFVAGKVQSLPVGAESVPAQELNGPTETNAEDVATTITGDDITVTDTTTQSIRTSTHDRVLFTDTPVMDAITIVWYLATFIALISFFLVMACADHNRCRSRKPSSDELTPPPTPAPSYRQFAPPSYDSLVFEKDNDSIFIIPYDTRMESDHVRSADELASNLEYIIEAPPTTTTTTIVRQMSSLSVRISDISEGRSEDVPTVVTLPNPTPAVQQNDATERYVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL68</accession>
    <name>A0A182PL68_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Argonaute 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PL68"/>
    <dbReference type="STRING" id="199890.A0A182PL68"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007685-RA">
        <property type="protein sequence ID" value="AEPI007685-PA"/>
        <property type="gene ID" value="AEPI007685"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007685"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="467"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="748"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007685-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1083" mass="122551" checksum="FA5430DEF3806C49" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL92</accession>
    <name>A0A182PL92_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin-conjugating enzyme E2 C</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
            <ecNumber evidence="12">2.3.2.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">(E3-independent) E2 ubiquitin-conjugating enzyme C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ubiquitin carrier protein C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin-protein ligase C</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EC" id="2.3.2.24" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A182PL92"/>
    <dbReference type="STRING" id="199890.A0A182PL92"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007709-RA">
        <property type="protein sequence ID" value="AEPI007709-PA"/>
        <property type="gene ID" value="AEPI007709"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007709"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000039">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7 20" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="22">
        <location>
            <begin position="30"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="19">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007709-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="176" mass="19898" checksum="83BCB0F99CCCFFF8" modified="2016-09-07" version="1">MAQNINPERAQSSNPSKQNDEALINNNNQAVSKRLQKELMALMLSSEKSISAFPEGENFFKWIGTISGPDGTVYKGQKYKLLLEFPNSYPYSAPNVKFITPCFHPNVDLSGAICLDILKDKWSALYDVRTILLSIQSLLGEPNNDSPLNSQASQLWPNQVEYKKYLDDFYEKNKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLK8</accession>
    <name>A0A182PLK8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZU5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLK8"/>
    <dbReference type="STRING" id="199890.A0A182PLK8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007828-RA">
        <property type="protein sequence ID" value="AEPI007828-PA"/>
        <property type="gene ID" value="AEPI007828"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007828"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000009">
        <property type="entry name" value="Ankyrin 2, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000095">
        <property type="entry name" value="Ankyrin 2, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000003">
        <property type="entry name" value="Ankyrin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000001">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF141">
        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="460"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="493"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="541"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="574"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="607"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="640"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="673"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="706"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="739"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="4">
        <location>
            <begin position="922"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="4">
        <location>
            <begin position="1081"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007828-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1188" mass="128612" checksum="2D4F11E644FA77AC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM59</accession>
    <name>A0A182PM59_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Casein kinase I isoform alpha</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CK1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PM59"/>
    <dbReference type="STRING" id="199890.A0A182PM59"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008032-RA">
        <property type="protein sequence ID" value="AEPI008032-PA"/>
        <property type="gene ID" value="AEPI008032"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008032"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000120">
        <property type="entry name" value="Casein kinase I isoform alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="10"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="300"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008032-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="331" mass="38842" checksum="F1954532FAE956B9" modified="2016-09-07" version="1">MNDFIVAGKYRIIRKIGSGSFGDIYLGINITNGEEVALKVESILARHPQLTYEYKLYKVLTGGVGIPHIRYFGQERSYHVLVMDLLGPSLEDLFNFCSRHFTIKTVLMLVDQMIGRLEYLHMKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDFRSRIHISYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVMMYFNRGSLPWQGLKATNKKQKYEKISEKKMSTPIEVLCKGFPAEFAMYLNYCRSLRFEEGPDYMYLRQLFRILFRTLNHQYDYTFDWTIMKQRAMQQGSTNPPAVTSGENKREERRDKDKLSSDTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM69</accession>
    <name>A0A182PM69_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VDE lipocalin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PM69"/>
    <dbReference type="STRING" id="199890.A0A182PM69"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008042-RA">
        <property type="protein sequence ID" value="AEPI008042-PA"/>
        <property type="gene ID" value="AEPI008042"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008042"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046422">
        <property type="term" value="F:violaxanthin de-epoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00301">
        <property type="entry name" value="lipocalin_FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000034">
        <property type="entry name" value="Karl, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010788">
        <property type="entry name" value="VDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF11">
        <property type="entry name" value="KARL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07137">
        <property type="entry name" value="VDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131456" description="VDE lipocalin domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="VDE lipocalin" evidence="2">
        <location>
            <begin position="47"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008042-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="220" mass="25374" checksum="00FE7E38FE50EBAE" modified="2016-09-07" version="1">MVRKGCGILARPAYCCCLLTALLLALFLADTAGQLPRRQPRNDRCPKVRAMRNFGLNAMMGSWYVIQYFASTEMFPEYGCMRSSFVTSDGYVTMNFTYVFLDDPVGTFQQGNITWIIPDYGQPAHWVHAESSYEEIYNTYVIDTDYRTWALIMHCAEKTKSQKYLSALMLAREPTLGQNVVNFLREKLPRYDIDVENMFPIPQTNCSRLDPNAYYSYQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMB6</accession>
    <name>A0A182PMB6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED11</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMB6"/>
    <dbReference type="STRING" id="199890.A0A182PMB6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008089-RA">
        <property type="protein sequence ID" value="AEPI008089-PA"/>
        <property type="gene ID" value="AEPI008089"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008089"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3490:FF:000001">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22890">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008089-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="134" mass="14912" checksum="7F3C374ED3FE028C" modified="2016-09-07" version="1">MTAIDKIQALDQIEKELIACLQSAGAALMELSKEKTSQKATETNVNQFLKSLNIVETKLSEQINYLTQVSTGQPHEGSGYASAKVLQMAWHRIQHVKSRIKDLEECKMRYIQANRMQSNRVGQNASSSTAGVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMP8</accession>
    <name>A0A182PMP8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Etoposide-induced protein 2.4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EI24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMP8"/>
    <dbReference type="STRING" id="199890.A0A182PMP8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008222-RA">
        <property type="protein sequence ID" value="AEPI008222-PA"/>
        <property type="gene ID" value="AEPI008222"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008222"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389:SF0">
        <property type="entry name" value="ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389">
        <property type="entry name" value="P53 INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008222-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47440" checksum="F2EA4729805CCF24" modified="2016-09-07" version="1">METLYRVGAAVLHGILDSIKGITVVFYLDREANRKVSHQPTTSPRLVGSAPRTKESLSSSQPTPRTTSAHSLISKRTEESKVLKRVLQCSGLNGGVFMLSILFFEYAVLPGLHLFLYYLFRNSSTMTTVWGWMQPSLSLMFHSFYVAPLFLMSKIINSLWFQDIADSAYKFRKGRPQLIPSISKLIADTLISLLIQILFLLQSTAIKYLPVPVPFACTAIYMVHMSLLCSLYAFEYKWFNMGWELHKRLTYIEQNWPYFLGFGLPLAVLSELPNSIVISGCVFSVLFPLFIISANEATPKVDVCETPLKLFSIVVALTNALFRGRTKPGKAALSQPLTSGDNSRGLTPPLSSSSSSFMFQQQQQQQQQQQHRQHSSQKHHHHRSHHRQPSPSSSVASSSFASVQTAQLHQHQPVLNRPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN04</accession>
    <name>A0A182PN04_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN04"/>
    <dbReference type="STRING" id="199890.A0A182PN04"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008328-RA">
        <property type="protein sequence ID" value="AEPI008328-PA"/>
        <property type="gene ID" value="AEPI008328"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008328"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="6">
        <location>
            <begin position="948"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1128"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="67"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="390"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="699"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="921"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1136"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008328-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1148" mass="129216" checksum="5E43FA7703B797DA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN64</accession>
    <name>A0A182PN64_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN64"/>
    <dbReference type="STRING" id="199890.A0A182PN64"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008388-RA">
        <property type="protein sequence ID" value="AEPI008388-PA"/>
        <property type="gene ID" value="AEPI008388"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008388"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000011">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008388-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="174" mass="18979" checksum="41B0C7D9C5248A85" modified="2016-09-07" version="1">MAASLLLRNACRRTLLQGYGSNVTLPLVAARTIVLKPVQADVRPGESHDDRNARLKRPQSPHLTIYSFQLTSMLSITHRFTGLALTGYITALGLGALAMPNDATHYLTMLEGLSAPTLIALKFTLAYPFAYHTVNGVRHLFWDMGKFLTIKEVYTTGYTMLGVSGVLAGLLTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNT5</accession>
    <name>A0A182PNT5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PNT5"/>
    <dbReference type="STRING" id="199890.A0A182PNT5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008614-RA">
        <property type="protein sequence ID" value="AEPI008614-PA"/>
        <property type="gene ID" value="AEPI008614"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008614"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015173">
        <property type="term" value="F:aromatic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015180">
        <property type="term" value="F:L-alanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015190">
        <property type="term" value="F:L-leucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904273">
        <property type="term" value="P:L-alanine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903801">
        <property type="term" value="P:L-leucine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015823">
        <property type="term" value="P:phenylalanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11329">
        <property type="entry name" value="AmyAc_maltase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042280">
        <property type="entry name" value="SLC3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031984">
        <property type="entry name" value="SLC3A2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673:SF1">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16028">
        <property type="entry name" value="SLC3A2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Solute carrier family 3 member 2 N-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="6">
        <location>
            <begin position="176"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008614-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="584" mass="64329" checksum="D734EE3CE7C47329" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNV9</accession>
    <name>A0A182PNV9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNV9"/>
    <dbReference type="STRING" id="199890.A0A182PNV9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008638-RA">
        <property type="protein sequence ID" value="AEPI008638-PA"/>
        <property type="gene ID" value="AEPI008638"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008638"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF98">
        <property type="entry name" value="CUTICULAR PROTEIN 56F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131664" evidence="4">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008638-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="181" mass="19384" checksum="1F44AD8FD56CFE1C" modified="2016-09-07" version="1">MKIFIAIATISMIALAAAEPPSPRNSFTSPSSNYLPPSQSYNGNNGYNYNSNDNGYNYPSASNGGNYAAPSQQYGAPSGSDGNGGYNYEDANAQPAKYSFEYNVQDFASGNDFGHMESRDGDRTVGRYYVLLPDGRKQVVNYEADQNGYRPTITYEDVGTGNGANGNNGGYGGNGQFNGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP02</accession>
    <name>A0A182PP02_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclin-dependent kinase 12</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cell division protein kinase 12</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="STRING" id="199890.A0A182PP02"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008681-RA">
        <property type="protein sequence ID" value="AEPI008681-PA"/>
        <property type="gene ID" value="AEPI008681"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008681"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07864">
        <property type="entry name" value="STKc_CDK12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000102">
        <property type="entry name" value="cyclin-dependent kinase 12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000074">
        <property type="entry name" value="cyclin-dependent kinase 12 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="1013"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="715"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="796"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="841"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="906"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1336"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="292"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="318"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
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            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
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            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
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            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="944"/>
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        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1042"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008681-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1375" mass="153227" checksum="5336EC885C9397C1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPR2</accession>
    <name>A0A182PPR2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPR2"/>
    <dbReference type="STRING" id="199890.A0A182PPR2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008941-RA">
        <property type="protein sequence ID" value="AEPI008941-PA"/>
        <property type="gene ID" value="AEPI008941"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008941"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000047">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="71"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="328"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008941-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="375" mass="42201" checksum="BC1E1D458F99273E" modified="2016-09-07" version="1">MGGLIGHRDTQETLAVLERLDLDTEKPTEEELARKFGYEDDYLKGTVSWWQHTKPQIWSLFDEPYSSNAAKIIGVISVFFICVSILSFCLKTHPDMRVPVIRNITVKTANGSTAWVLDKTQTNAHVAFFYIECVCNAWFTFEILIRFISSPNKCEFVTSSVNIIDYIATLSFYVDLVLQRFASHLENADILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQANPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRTAGQGGGIGMPGSGPMARRMNQVKTKDLGPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQK4</accession>
    <name>A0A182PQK4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQK4"/>
    <dbReference type="STRING" id="199890.A0A182PQK4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009235-RA">
        <property type="protein sequence ID" value="AEPI009235-PA"/>
        <property type="gene ID" value="AEPI009235"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009235"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009235-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="458" mass="48495" checksum="BD69BDBB09F8CF5D" modified="2016-09-07" version="1">MLGKYGEASSGSMKNLENGLRDRVLYHQNMLSMNLATEFYHNPFLASGAAGTGSGSNTGASPIAQSQKMLSSLASTSSSSSSSSAGHPQQHAANNGSSTVVAAVPNSPSTAQPFQCQLCQKCFISSAVLAQHMKTHDNNGFATRESGNYVQQQSASPAVASISKTSPPPAAATQHIIKSEYIGGTVTNTMGHYTYGMAKQFECHICHKSFMTMVNLNLHLQIHESAIKPLAQTQHVYSAGQTASSSASTSYHHTGQHHSQQQQQPHHSIVPGVTSSDVVCQICHKTFSTAEQFAVHMKIHENEFKNRALYHSGSANGGGESGGGPPVPTSNGVGDHFYTASQPAHHNLAPPPPHLDASKGHRCPICHKMSNNIIEHIKQHEGQLQGTSDGPGYHQTNEDSQSSLDDDNEGGCGAGGDENICSGVQFSPARRFVLSFAIASSSAGSLHAPPCFRRCNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQR9</accession>
    <name>A0A182PQR9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQR9"/>
    <dbReference type="STRING" id="199890.A0A182PQR9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009300-RA">
        <property type="protein sequence ID" value="AEPI009300-PA"/>
        <property type="gene ID" value="AEPI009300"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009300"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009300-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="84" mass="9486" checksum="1B4329DCB390F0C3" modified="2016-09-07" version="1">MAFAHSAQLLWTDCGYPRWSVFFTLPNAIFFYMLFNDFYKKSYGSKKPQPTPVTAADRNASNDVASNLKSVENNNSPKVASKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR56</accession>
    <name>A0A182PR56_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PR56"/>
    <dbReference type="STRING" id="199890.A0A182PR56"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009437-RA">
        <property type="protein sequence ID" value="AEPI009437-PA"/>
        <property type="gene ID" value="AEPI009437"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009437"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009437-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="410" mass="46770" checksum="5EEF4D21BDA67C79" modified="2016-09-07" version="1">MGRLFEANSFVETLRILYYIAKAFGLIAFTTTFEKVGIQRSFKDVLVFVAFMFFNGFIVFKAGIPPKAGSPSYFNSSLIEFILSLFLTLQLIALVGIPIANYVQAYMYDRLIYLIMEVDKGLAHLGYRHDYSIEYFYSTVYLCVTLGLQLTCLTGTAFSNPFLVDYNTGSNITALMGFIMCNLVYIMTSCFCCVTLWAIVYRYQKINATFCMYFHTQSEPNKQLLPLCEKETIKTIAMLYMKLGAAVQVYNRCFFIHTFYIIASAFGLNLVSFFTIIHVYLASTDITITDPLILSQLFLSLFFILVILQVMFAGNLLHKKATQTAILLHKAAIYNDCGSQILEQLRCFSVQLSHGIPKVSCYFYDIDWSFLLTTISSFATYLNILVQFDIMQIRTSSTTFNHTLLSFERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRC1</accession>
    <name>A0A182PRC1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="2">Epiroticus2</strain>
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        <property type="gene ID" value="AEPI009505"/>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Howell P."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
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                <person name="Larimer J."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Epiroticus2</strain>
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        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009740-PA"/>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="671" mass="67294" checksum="78A8FEAD6E7769E5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS92</accession>
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                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Larimer J."/>
                <person name="McCowan C."/>
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                <person name="Poon T.W."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009827-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="860" mass="94236" checksum="743E93989940D14C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSB7</accession>
    <name>A0A182PSB7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PSB7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009852-RA">
        <property type="protein sequence ID" value="AEPI009852-PA"/>
        <property type="gene ID" value="AEPI009852"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009852"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009852-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="85" mass="9482" checksum="5CCA2BBDD9C0C78E" modified="2016-09-07" version="1">MMIAVDVITRNAKNENPATETNGTVVASETIEIAIAIDEIIEIIRNDWIALIIVSETVIVDAVGMVAKSNRNDHRDRDRSRSRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTZ3</accession>
    <name>A0A182PTZ3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PTZ3"/>
    <dbReference type="STRING" id="199890.A0A182PTZ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010429-RA">
        <property type="protein sequence ID" value="AEPI010429-PA"/>
        <property type="gene ID" value="AEPI010429"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010429"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010429-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="201" mass="19894" checksum="50D794F129032083" modified="2016-09-07" version="1">MNTQKTVKTIYLRPYKDIFPGGGHNQLSSLYPQPVMERGGGGGGSGGGGSGGPTPSSLGDTMSDSAGLCLQDLVGVNGAGGGGAGGGGGGGGGGGAGVNSTLADHLHGAGAHHGPHHTHHSLHDGLVSGGVSVSSAITSLMSPGGINSGGLGHLHHGAPDLSAHHHHHHHHHQHHHSSALHEPLEKLKLPKVMQLAAQNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU49</accession>
    <name>A0A182PU49_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SPRY domain-containing SOCS box protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU49"/>
    <dbReference type="STRING" id="199890.A0A182PU49"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010485-RA">
        <property type="protein sequence ID" value="AEPI010485-PA"/>
        <property type="gene ID" value="AEPI010485"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010485"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12876">
        <property type="entry name" value="SPRY_SOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035754">
        <property type="entry name" value="SPRY_SPSB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF12">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="8">
        <location>
            <begin position="106"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010485-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="171" mass="19567" checksum="179AAEC35C80BECD" modified="2016-09-07" version="1">MMFGIGTKKARLHVNMFTNLLGEDRNGWGLSHKGLLWHGGVARNYTKRFKENQPTKIGLLFDGIAGTLTYYKDDVCLGIAFRGLNEIREPLYPIVCSTAAKTEMLLSETRRDFVNLQDRCRAIIIKHINTREKLDRLALPYFIKNYLAEAVTESSATVTPLELHLIDQYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU54</accession>
    <name>A0A182PU54_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU54"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010490-RA">
        <property type="protein sequence ID" value="AEPI010490-PA"/>
        <property type="gene ID" value="AEPI010490"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010490"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015375">
        <property type="term" value="F:glycine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF313">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010490-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="625" mass="70629" checksum="7EB9317579FC7209" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUN1</accession>
    <name>A0A182PUN1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus</location>
            <location evidence="13">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUN1"/>
    <dbReference type="STRING" id="199890.A0A182PUN1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010668-RA">
        <property type="protein sequence ID" value="AEPI010668-PA"/>
        <property type="gene ID" value="AEPI010668"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010668"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000092">
        <property type="entry name" value="Transport protein SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000004">
        <property type="entry name" value="vesicle-trafficking protein SEC22b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="16">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010668-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24656" checksum="609BDA6424AC361C" modified="2016-09-07" version="1">MALMTMIARFVDGLPLVGTMQEDEQSGRSILEYQNQAKLLFRKLGPNSPTRCSIETGPYLFHYLIEHDVCYLVMCDKMFSKRIAFLYLEDIAQEFHNNYGRKVNTVTRPYAFIEFDIYIQKARKNLTDRRRNINTINNQLQDVQRIMVQNIDDVLQRGTVLSELDTKTQNLSMLSQKYKKDASYLNRKSLYVKGAVAGIVLIIFVLYFWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUQ3</accession>
    <name>A0A182PUQ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUQ3"/>
    <dbReference type="STRING" id="199890.A0A182PUQ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010690-RA">
        <property type="protein sequence ID" value="AEPI010690-PA"/>
        <property type="gene ID" value="AEPI010690"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010690"/>
    <dbReference type="UniPathway" id="UPA00662"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050220">
        <property type="term" value="F:prostaglandin-E synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03197">
        <property type="entry name" value="GST_C_mPGES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034334">
        <property type="entry name" value="PGES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034335">
        <property type="entry name" value="PGES2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782">
        <property type="entry name" value="MICROSOMAL PROSTAGLANDIN E SYNTHASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782:SF5">
        <property type="entry name" value="PROSTAGLANDIN E SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01182">
        <property type="entry name" value="Prostaglandin_E_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01203">
        <property type="entry name" value="Prostaglandin_E_synthase_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="111"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010690-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="391" mass="44493" checksum="B0FB6DAA6F15FA37" modified="2016-09-07" version="1">MATFRLGAVASFATRLPHQNVAKLQRINLVRQLATGAAPKKPSSTLGLAIKGMAIGALVGTGWSGYSFFKGGPTDHMLHEHVGPKVLDKLPDVKIMRKVVNPKDDSGLDLVLFQFQTCPFCCKVRAFLDHSGLSYSVVEVDAVLRQDIRWSDSKKVPILLAKTKSGKYVQLTDSSMIVSSISSFLRDKKQDIGELAKYYPSISYENDAGRKVFDIMNKYFLMFQEKKGDNRSKEEQEEERKWRAWADDHLVHLISPNVYRTKDEALETFEWFSDVGEWSIHFPKWERDLMVYVGAFAMWGISKRLKARHQLSDDVRSHIYDACDRWINEIEKKKTTFHGGSQPNLADLAVFGVLNSMEGCQAFKDCLENTKIGPWFYAVKERVLRNRGNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUZ9</accession>
    <name>A0A182PUZ9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUZ9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010786-RA">
        <property type="protein sequence ID" value="AEPI010786-PA"/>
        <property type="gene ID" value="AEPI010786"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010786"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131890" description="ZP domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010786-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21912" checksum="CA8084FC1AE638FA" modified="2016-09-07" version="1">MDVLIYGLLLQLTTFITFVRPEQPSSLPAIFLYDDFGHCKAVASVYCYARTILRVDQFPAGFEIPQTESTDRIVHNHRPHCLELGICLRNCEQEVNKLTASSRETLFQPQIPVNFTFLIPSELFPTMQSDKRRYETLVNVCVNQRLRARYNMTGYTTLEYCRPDPKQSARPYGTVIKRRKIVIGFVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV13</accession>
    <name>A0A182PV13_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vesicle-associated membrane protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Synaptobrevin-like protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">Phagosome membrane</location>
            <topology evidence="12">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Secretory vesicle membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">trans-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Late endosome membrane</location>
            <topology evidence="10">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Lysosome membrane</location>
            <topology evidence="11">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PV13"/>
    <dbReference type="STRING" id="199890.A0A182PV13"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010800-RA">
        <property type="protein sequence ID" value="AEPI010800-PA"/>
        <property type="gene ID" value="AEPI010800"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010800"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15871">
        <property type="entry name" value="R-SNARE_VAMP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000015">
        <property type="entry name" value="Synaptobrevin 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF179">
        <property type="entry name" value="VESICLE ASSOCIATED MEMBRANE PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="17">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="18">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010800-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="233" mass="26749" checksum="23E56D54FE8EB3F7" modified="2016-09-07" version="1">MPILYSMVSRGQTVLARYADCIGNFTEVTEQIIPKIQLIDHKLTYLHGNYLIHYICDNRVIYLCITDDRFDRSRAFLFLQDINERFICMYGLTVATAISYAMNTEFARTLAAQMRQFNEGQEQDAISRVNGEIDELKDIMVKNIENITNRGERLELLVNQTENLRNNSVTFRQTSRNLARTMFWRNVRMYFLVAAILLFVIYVIVSMACGGLLWQSCIHSSPAPKGPPNAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVF7</accession>
    <name>A0A182PVF7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kintoun</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Dynein assembly factor 2, axonemal homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIH1 family. Kintoun subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVF7"/>
    <dbReference type="STRING" id="199890.A0A182PVF7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010944-RA">
        <property type="protein sequence ID" value="AEPI010944-PA"/>
        <property type="gene ID" value="AEPI010944"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010944"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06463">
        <property type="entry name" value="p23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03069">
        <property type="entry name" value="Kintoun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034727">
        <property type="entry name" value="Kintoun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF3">
        <property type="entry name" value="PROTEIN KINTOUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="5">
        <location>
            <begin position="38"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="6">
        <location>
            <begin position="257"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="566"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="649"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="770"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="798"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="872"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010944-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="897" mass="100309" checksum="4FBA529D8FAA7046" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW52</accession>
    <name>A0A182PW52_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PW52"/>
    <dbReference type="STRING" id="199890.A0A182PW52"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011189-RA">
        <property type="protein sequence ID" value="AEPI011189-PA"/>
        <property type="gene ID" value="AEPI011189"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011189"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13717">
        <property type="entry name" value="PBP2_iGluR_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000160">
        <property type="entry name" value="GLutamate Receptor family (AMPA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000080">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000284">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 3-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="766"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="17">
        <location>
            <begin position="344"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="18">
        <location>
            <begin position="354"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="683"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="14">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="14">
        <location>
            <position position="582"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="14">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="695"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011189-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="888" mass="100428" checksum="834F8B93452786B0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW82</accession>
    <name>A0A182PW82_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PW82"/>
    <dbReference type="STRING" id="199890.A0A182PW82"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011219-RA">
        <property type="protein sequence ID" value="AEPI011219-PA"/>
        <property type="gene ID" value="AEPI011219"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011219"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001707">
        <property type="term" value="P:mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20192">
        <property type="entry name" value="T-box_TBXT_TBX19-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000002">
        <property type="entry name" value="T-box transcription factor Brachyury"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002070">
        <property type="entry name" value="TF_Brachyury"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF106">
        <property type="entry name" value="T-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00938">
        <property type="entry name" value="BRACHYURY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="9">
        <location>
            <begin position="78"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="523"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="601"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011219-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="644" mass="69560" checksum="A39FC4CD9F4BBBF5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW94</accession>
    <name>A0A182PW94_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PW94"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011231-RA">
        <property type="protein sequence ID" value="AEPI011231-PA"/>
        <property type="gene ID" value="AEPI011231"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011231"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131910" evidence="1">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011231-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="156" mass="16529" checksum="EF476CE1229148AE" modified="2016-09-07" version="1">MKSFVAAALLAVVVVAEAGYIAPYNDLAHTVVHDTGAYYGDHYAPFAYAAHGYAAPYAAYYGNPSGTYSYWGAHGPTVVQENAASLAAPLHGAHLYAPYDTHYGIYAPLKATVVQSNLASNLANHWGYPAAYGAYGYGYGYNKYLAGAAPTAKYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWA8</accession>
    <name>A0A182PWA8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1</fullName>
            <ecNumber evidence="5">3.1.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Metazoan SpoT homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Penta-phosphate guanosine-3'-pyrophosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ppGpp hydrolyzing enzyme involved in starvation response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>guanosine 3',5'-bis(diphosphate) + H2O = GDP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:77828"/>
            <dbReference type="EC" id="3.1.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MESH1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.7.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PWA8"/>
    <dbReference type="STRING" id="199890.A0A182PWA8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011245-RA">
        <property type="protein sequence ID" value="AEPI011245-PA"/>
        <property type="gene ID" value="AEPI011245"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011245"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008893">
        <property type="term" value="F:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000012">
        <property type="entry name" value="HD domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052194">
        <property type="entry name" value="MESH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246:SF1">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13328">
        <property type="entry name" value="HD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011245-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="181" mass="21053" checksum="CB7B19DFC5EEE4EE" modified="2016-09-07" version="1">MEIPPTPADLLKIYTECVNFAAVKHRNQRRLDSQETPYINHPIAYILTEAGITDFEVLQTAILHDTVEDTDTSFEEIESLFGKTVRLLVQEVTDDKSLPKQERKRLQIEHASTTSHRAKLVKLADKIYNLRDLQRCKPKNWTNERCREYFCWAKQVCDNMKGTNAALESILDDIFRQENVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWG8</accession>
    <name>A0A182PWG8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWG8"/>
    <dbReference type="STRING" id="199890.A0A182PWG8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011305-RA">
        <property type="protein sequence ID" value="AEPI011305-PA"/>
        <property type="gene ID" value="AEPI011305"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011305"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011305-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="231" mass="26661" checksum="258113787AE5B75E" modified="2016-09-07" version="1">MAETAGSSSKTFAEKQADRMARLKQLHNQRNEARASNHQEVVAEHERKKLPANWEARQRQAEWLMGDLKARTEAEEKGLDYNRVKMLNVSAAEADRIDKLKAKKRNADPGFSDYEAQTARQYNRLVKAMPPRDLAKYEEQKEKYGNAFYGGPNVILQGLHKDTPAAIDNMVKDLEGQIAKRKKFSRRRTHNDDADIDYINEKNARFNKKLERFYGEHTAEIKQNLERGTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWS1</accession>
    <name>A0A182PWS1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWS1"/>
    <dbReference type="STRING" id="199890.A0A182PWS1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011408-RA">
        <property type="protein sequence ID" value="AEPI011408-PA"/>
        <property type="gene ID" value="AEPI011408"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011408"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011408-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="231" mass="25857" checksum="DA9AABA44F7F4159" modified="2016-09-07" version="1">MEREYAEWRHAVEDSIKEHRAKRSIRPYNTGAMAAARAAPYGANSTVVPTPVQRASSGIPLTPSQKAARDNTPKELPVFSGLVEQWPMFITAFERSTATCGFTDDENLLRLQQALRGPALESVDHMLLLPDGLTEVLDILRTEYGRPDLIVDSLVDKVRRLPPVIAERLDTLANFGKAVRKLCATIRASGLEDYDCNVALLKELVAKLPAERRLEWARYKVKLTRKTVGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWY4</accession>
    <name>A0A182PWY4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWY4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011471-RA">
        <property type="protein sequence ID" value="AEPI011471-PA"/>
        <property type="gene ID" value="AEPI011471"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011471"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011471-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="82" mass="9258" checksum="72CBC1771585D237" modified="2016-09-07" version="1">MNSHRLVVEDRKSKQRFFIDDADASVILRQHNSVSCKSSSMIMFAANSTHIQPTSTPPSKEPTSINSSIFWPISVTSVWYMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PXE7</accession>
    <name>A0A182PXE7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PXE7"/>
    <dbReference type="STRING" id="199890.A0A182PXE7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014039-RA">
        <property type="protein sequence ID" value="AEPI014039-PA"/>
        <property type="gene ID" value="AEPI014039"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014039"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030719">
        <property type="term" value="P:P granule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="308"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014039-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="563" mass="61869" checksum="28B7620752BF5836" modified="2017-12-20" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ78</accession>
    <name>A0A182PZ78_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZ78"/>
    <dbReference type="STRING" id="199890.A0A182PZ78"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015143-RA">
        <property type="protein sequence ID" value="AEPI015143-PA"/>
        <property type="gene ID" value="AEPI015143"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015143"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF104">
        <property type="entry name" value="CYTOCHROME P450 308A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015143-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="499" mass="57520" checksum="A16A69582EBE6635" modified="2016-09-07" version="1">MFGLYVALIVLAVCLYFKWSCSYWTRAGNVAGPKPLPIFGNLLEQLTGQKHFGEIFEEMYRAFPQASWVGYYKISNQPGIVVRDLELVKEVLTSSFSSFNQNDFIIDEKIDPLLAYNPFTQSGERWKERRNQMTSVFTMNRIRATFPLVQQVADEFVQFIARTRKTDPHFEAKDICAKYTINVVASVGFGIDAESFTNPNAEFPLMGNSLFAPTWMTAIRSQLALFAPGLAKFLRVPFIPGYVDRWFRRMVQETIRQRKDAKRHDFFQVMYDNLSENGTVEVNENHVVGHSVTFLTEGFETSSSMMSYLLYELAANPSIQERVVKELRTVMEESGGQLTEAGLHKLVYMEAAMMETLRMHTPVFTLPRICTKDYELPPQFPNDTKRITLRRGTSVIIPVYAIHYDPEIYPMPYTFDPDRFMEENRKNRPRHAFLGFGEGPRLCLGMKFALHQSKIGIATLLNKYRVKLSSKQELPLEFAKSSFLLCPKTGIWLNFEDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZB4</accession>
    <name>A0A182PZB4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZB4"/>
    <dbReference type="STRING" id="199890.A0A182PZB4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015179-RA">
        <property type="protein sequence ID" value="AEPI015179-PA"/>
        <property type="gene ID" value="AEPI015179"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015179"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF187">
        <property type="entry name" value="CYTOCHROME P450 4AE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015179-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="504" mass="57673" checksum="796EA7053CE36BC0" modified="2016-09-07" version="1">MAISAFLFLAALLCSVLYIVHKVHRNRKRAQVLLQQLPSFRALPSLPVLGSAHLFLDTTPDGTLRTIVNCHRRYGKNLLMQELCNDFKLLTCDPRVIEQVLQAKTIVKSNFYHFLQPWLGRSSVVSSGERWHNLRKVTNPAFHYNMLQDFLPTIETQAAILVRKLVQHVDGPDLDVYEPLQYFAMDIICETAMGVRLACQSNPRVQFVQDSEELVDLIYKRIFNPLLASDLVYACTRAGRRAKATVRSIHQFTRSVICERMKHMQDVPVSRESERRSTFMDLLLQTRLAGDELLSDDDIRGEVNTFMFAGHETVTSCLAFALYHLSRNAHVQQRLYDEIVSVYGSATEPVALTYATLTELKYTELVIRETLRMNPTVPMIGRLAAGDMVIDGVTIPTGTEIMINIYVMHNDPHLYPDADQFRPERFLEDLQPYSYLPFSTGVRSCIGQRFAMLEMKTALVKLLSRFRFVPCEEENALQVKANLTLKPFRGSFVKLVDRSMHYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PLY8</accession>
    <name>A0A240PLY8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Caspase family p20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PLY8"/>
    <dbReference type="STRING" id="199890.A0A240PLY8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015223-RA">
        <property type="protein sequence ID" value="AEPI015223-PA"/>
        <property type="gene ID" value="AEPI015223"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015223"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF232">
        <property type="entry name" value="AT03047P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="4">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="3">
        <location>
            <begin position="157"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015223-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27632" checksum="1A22D3CD0B448A8E" modified="2017-10-25" version="1">MDSPPKLEIEKYNTNNPKRGIAVILHDTNNRKGTEKDLKRLIGVLSALKFVVRVITDKTVTEIRTALELVSKEDHSDNDCLVIVAMCHGSKDTLIFDGRELHIKELWENFVGNRCPSLFDKPKLVFVQSCRGEKFDSGSKLETDSAPNLVDPVSVLIPMYAHLLVMYSCYEDYVSYRSEEEGTWFIQALCNVLRSDIENENLLTLLTHVSNLVANRSAETASGSFKQIPVINSMLTKQFYFVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PM69</accession>
    <name>A0A240PM69_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">trypsin</fullName>
            <ecNumber evidence="12">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A240PM69"/>
    <dbReference type="STRING" id="199890.A0A240PM69"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015415-RA">
        <property type="protein sequence ID" value="AEPI015415-PA"/>
        <property type="gene ID" value="AEPI015415"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015415"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF97">
        <property type="entry name" value="GH13245P2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0222">Digestion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012489701" description="trypsin" evidence="14">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="48"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015415-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="274" mass="29439" checksum="B76247D3C96F1DCC" modified="2017-10-25" version="1">MSNKVTIILAVLVAVVACAQARVSHQKRVPYPLPRFLLRTQHNAGHRIVGGFEIDVAETPYQVSLQRNRRHICGGSILSGQWVLTAAHCTDGSTPQRLTVRLGSSLHASGGTIVRVARIIPHPNYNDENIDFDYSLLELASPITFSDVVRPIALPEQDEPVEDGIMTIVSGWGSTKSATESNDVLRAANVPTVSQEECSEAYNQSGGITDQMLCAGYHQGGKDACQGDSGGPLVADGKLIGVVSWGYDCARAGFPGVYARVASVREWLRENSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PPM6</accession>
    <name>A0A240PPM6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PPM6"/>
    <dbReference type="STRING" id="199890.A0A240PPM6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015239-RA">
        <property type="protein sequence ID" value="AEPI015239-PA"/>
        <property type="gene ID" value="AEPI015239"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015239"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000027">
        <property type="entry name" value="AMSH-like protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000010">
        <property type="entry name" value="AMSH-like protease isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="249"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015239-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="417" mass="45938" checksum="C529D51FE05A3394" modified="2017-10-25" version="1">MSTQQKTHPVEMGPIEPHQRLQKLVADSQRVSIDPTMPINRYYRSGNQIVESADRSLREGNLEKAFTFYLRFVTIFVELIRDHPGYKSVPPADKQQTKDKIKKIMPRAEEIRKTLLERYTTEYRLYLKQLQLQAEQEEKEGEARKAAAAAAAATAAAAAAAKAADQQPTTSYAPSAPPSHVAVISDTDAKLIDQVFYPSDFLTDRSQTTGLPGTGLLLAGEDRRFDRALKPTALPTVPATGGVAGFRSIVVPTDTMQKFLELAAANTAANLETCAILAGSLGQARFTITHVIFPKQSGTSDSCNTMNEEEIAVVQDRHNLITLGWIHTHPSQTAFLSSVDLHTHCSYQLMLEEAIAIVCSPKYRETGFFNLTPHGMDSISQCRQTGFHPHPAGQPLFTEAQHIILSDTVAARVIDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FGL4</accession>
    <name>A0A9I3FGL4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A9I3FGL4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015529-RA">
        <property type="protein sequence ID" value="AEPI015529-PA"/>
        <property type="gene ID" value="AEPI015529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF54">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="132"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015529-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="425" mass="49308" checksum="DD27CB89A76990B4" modified="2023-06-28" version="1">MPELLTTSLPDYISAGLEQVAREQGFTDGLYRFESESGSNMGDGFVGQLLKVFIREADRELVVLCKLLPDNEMRKQQGVPLFDRETDAYVKILPMLLKFQREKALPEHVPQFDNVPRCYYAKTTVDKMESVIIMEDLRLQAFRMWDKANPVDFEHARLLMVTLGRLHALSFALKDQQPEEFAQCREFTDPMGKMLDLDPTKAFEKMMAGMCRRAIDTLEKHDTFRREKLQQLEKRCVQEIVACVDGKAAEPYAIVGHGDCWSNNMMFQYQEDNETPSYIKLIDWQLSRYGSPVLDLVYFIFNCTDEEMRSDSYHRLLNIYYHSLSEHLHNLGGDVERQYPRSAFREQLKKFGRYGLVMSMMVLPIICTPNDELPNTDTAMEGFMNDMNNGNTEAELVYGTTEKAAIRYKKRMSGCIRDCIRYGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FH50</accession>
    <name>A0A9I3FH50_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A9I3FH50"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015508-RA">
        <property type="protein sequence ID" value="AEPI015508-PA"/>
        <property type="gene ID" value="AEPI015508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000653">
        <property type="entry name" value="AGAP002654-PB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
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        </location>
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            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
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            <begin position="392"/>
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        </location>
    </feature>
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            <begin position="626"/>
            <end position="637"/>
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        <location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015508-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1197" mass="126479" checksum="9ED0F322387D811D" modified="2023-06-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FHD2</accession>
    <name>A0A9I3FHD2_9DIPT</name>
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        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A9I3FHD2"/>
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        <property type="gene ID" value="AEPI015526"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF61">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
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    </dbReference>
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        <property type="entry name" value="ATP6V0A1"/>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        <location>
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            <end position="784"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="699"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015526-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="829" mass="94786" checksum="8D30C4588BB6CD4F" modified="2023-06-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZK3</accession>
    <name>A0A182NZK3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182NZK3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000084-RA">
        <property type="protein sequence ID" value="AEPI000084-PA"/>
        <property type="gene ID" value="AEPI000084"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000084"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130555" description="Right handed beta helix domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="3">
        <location>
            <begin position="217"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000084-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1311" mass="145590" checksum="EFD7990A615CB84F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZX5</accession>
    <name>A0A182NZX5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP135/TSGA10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZX5"/>
    <dbReference type="STRING" id="199890.A0A182NZX5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000206-RA">
        <property type="protein sequence ID" value="AEPI000206-PA"/>
        <property type="gene ID" value="AEPI000206"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000206"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051877">
        <property type="entry name" value="Centriole_BasalBody_StrucProt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544:SF0">
        <property type="entry name" value="NUCLEOPROTEIN TPR_MLP1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000206-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="148" mass="16777" checksum="34353661A759A0F5" modified="2016-09-07" version="1">MEIEARHSELRKRLDGLGFGHPLPLSAIGIVSAILDDLIQTSEKLKCANQKIEVLHQEKAAWELGVEPYKCDNSRLLAECNELHLELIKQQDKHILANTELRSRVRSLQAEKKQLEEKCLAAECKIRDLQAGVSESVKSRKDTANKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0E3</accession>
    <name>A0A182P0E3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0E3"/>
    <dbReference type="STRING" id="199890.A0A182P0E3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000375-RA">
        <property type="protein sequence ID" value="AEPI000375-PA"/>
        <property type="gene ID" value="AEPI000375"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000375"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000375-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="361" mass="41008" checksum="CE7A76ADDD52EC44" modified="2016-09-07" version="1">MFDNNINNYVLKVELAKCFGNLGTVYLAQHLPTRQHVAVKKFLVEDLKNDISYVMDEAKHLREFDHPNILSYHTAFVHNLDLYFVLPLMCYGSCRDTMTNYFETGFPEPILVCILRDILQGLVYLHWKGYIHRSIRASHVFLNETRAVLGGFRVCTSFLGEGKRIRNLHELPPHSVKSLNWLAPEVLAQNLTGYTEKSDVYSLAITVYELANGLEPFSNITTTLMLTEKMKGGYLPMLLDASTIPSEEVVLAQSAEAKSNEAAAASMRQIYASRQFSDALHKFAEQCSESDPKNRPSATALLSHPVFKQVSHTNIREQFALHCIQTVDFDSIQDFDINMTNSFSQMHMDADGSFEWDFDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P125</accession>
    <name>A0A182P125_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P125"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000607-RA">
        <property type="protein sequence ID" value="AEPI000607-PA"/>
        <property type="gene ID" value="AEPI000607"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000607"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000607-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="237" mass="26558" checksum="87ABD99D707A3633" modified="2016-09-07" version="1">MPVGEDTPVQESAVEAQDDMDKAETFGFGYHKVIHLVCAFALIAVVASMPNPARPMIPMRPIVKRETIAPEAAVPVGKDASAQESAVEAQDDLEKAETFGFGYHKVIHVGVPVYPAFYHYPLYYPGYHGYGMAKQETELLCVCACILVAVAALPSAIEEPVRQDGIVKRDTVAAAPMQEEDAPAVESAVEAQDDMDRAETFGFGYRKYIHIYPRYYPRFYYGGYYPRYYYGHYGHYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2N8</accession>
    <name>A0A182P2N8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">snRNA-activating protein complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Small nuclear RNA-activating complex polypeptide 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2N8"/>
    <dbReference type="STRING" id="199890.A0A182P2N8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001172-RA">
        <property type="protein sequence ID" value="AEPI001172-PA"/>
        <property type="gene ID" value="AEPI001172"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001172"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001172-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="412" mass="48303" checksum="529ED35046AD9683" modified="2016-09-07" version="1">MEKIYCPRTEKVISVWEALDEFQKEMYPPGLDRIVETDHDIMEAMGLASNSAEFDRLLESVDVGQLSSKKDIPVRTFVPHKTGTRPKPTEIPPKAARFNCVQRVTVRKSVKDQRNVDVKLRYTRHKYLERKEELELRKDLVPFREMVLVLRFYEPFKYKAGRRLGHPKFSQEFYVLSSQFLTELKDKIFCHCDSGPFYEISKDRAAEPAQKPPKSGFFFIHDTFYNDYRDDANHDYSTVIRKWAERQSLIGELQSARMEDTRFGDLKFRVGYPQVNGPLRINATTLIMIVLFQLYQHQGNCEHLFVISDCRLLATTDILTRSRYPWLNSYGFSRDVPCNICGHCQAQYIVQNCSRHIFDPAYLCENCVETYHYTEDGEKIGEFELYKYTLTMVRADVDEEEENDKKEASTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P343</accession>
    <name>A0A182P343_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182P343"/>
    <dbReference type="STRING" id="199890.A0A182P343"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001327-RA">
        <property type="protein sequence ID" value="AEPI001327-PA"/>
        <property type="gene ID" value="AEPI001327"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001327"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000072">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000130">
        <property type="entry name" value="Protein kinase, cGMP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF144">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="13">
        <location>
            <begin position="481"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="13">
        <location>
            <begin position="599"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="652"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="945"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="976"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001327-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="995" mass="111441" checksum="54AFD448D01CA8C1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3M5</accession>
    <name>A0A182P3M5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xyloside xylosyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3M5"/>
    <dbReference type="STRING" id="199890.A0A182P3M5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001510-RA">
        <property type="protein sequence ID" value="AEPI001510-PA"/>
        <property type="gene ID" value="AEPI001510"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001510"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140560">
        <property type="term" value="F:xylosyl alpha-1,3-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042465">
        <property type="entry name" value="XXLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46612">
        <property type="entry name" value="XYLOSIDE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46612:SF1">
        <property type="entry name" value="XYLOSIDE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001510-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="48767" checksum="42AA4C5C41BDA58A" modified="2016-09-07" version="1">MGMNKALLVFIVASGFLLFIYANSSVFNRHLVQKEDPERLTAAAAALVHRNHQHHQHQHHGGGKHRNGTVATGEDGTSDPSTSKLKRVKYISKGTNDTEYNIFLIYTKESQNLILHSQLELFLRSLLKYSTIELHLHIITDEQSERSAEELIKQQIERFQRTAFYTLYDVRDCAEKISDIVHGMMPLFNYRSGSYYSDALFLLSLGLHRIVDRNMRRAILIDCDVVFRASVKELFDQFDQFAPDQLFGLAPELTPVYRHVLSRYRMNNPQTIFGSPYYLDKVPASLLDAQPSSPKDVSRSKKTPARVGEKLLHGYPGLNSGVVMLHLDRIRRSRLYEEIIKESTVRNMAEKYSFQGHLGDQDFFTLMGFEFPGLIYRLDCVWNRQLCTWWREHGYSDIFDSYFHCEGTVKIYHGNCNTRAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3S8</accession>
    <name>A0A182P3S8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3S8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001564-RA">
        <property type="protein sequence ID" value="AEPI001564-PA"/>
        <property type="gene ID" value="AEPI001564"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001564"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130856" description="TIL domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001564-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10155" checksum="DFC8409390BEA144" modified="2016-09-07" version="1">MHMYGKLCALFLLLAWCSSFALSQRPVLNIQVCSDFEEYTYSYACQPTCAERTCTITSESAKRETCTCKLGYIRQYTKGPCIRTSRCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3T6</accession>
    <name>A0A182P3T6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">UPAR/Ly6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3T6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001572-RA">
        <property type="protein sequence ID" value="AEPI001572-PA"/>
        <property type="gene ID" value="AEPI001572"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001572"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF20">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130805" evidence="10">
        <location>
            <begin position="28"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="11">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001572-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="156" mass="16740" checksum="C5FC2AD182541B90" modified="2016-09-07" version="1">MMKQVKISDVLVACLFFGALSTQSVSALRCYQCTSPNSWSDCQGGAQIIECSSNSQMSVMGHSLFLPAQARQVEPACLSVYAKGTVGGTTGYAYIRDCLYNDASLCSMIQDTLPPEIRVVDCDLCTTDLCNGANRSITAVTLSSVLMMAIAVLLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P428</accession>
    <name>A0A182P428_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P428"/>
    <dbReference type="STRING" id="199890.A0A182P428"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001664-RA">
        <property type="protein sequence ID" value="AEPI001664-PA"/>
        <property type="gene ID" value="AEPI001664"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001664"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052808">
        <property type="entry name" value="GPCR_Mth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017611433" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="128"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001664-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="424" mass="49517" checksum="931CE1318D725ED0" modified="2019-01-16" version="2">MERTMALVTTLATLTLVLAVGGELVTTHDQKANQCCQDGYLVDGKQQRCLRTDGNYTTAMHLNCSHSYMIFREIEQEVYVDETGSLVDGEFRIQRSDYCAAHTQEGEGTQPVFVVCFNVVNMETIATMLVSKGIMMLISVFFLLVTLYIYYIIPDLRETQDKVTSAAVASLAVFMFLLSLIQLWVSLTHTAFCTVIAFLMYFFLISYFAWLNMVMANVWKLTVARRWKIRERSWYVLNHIYAMTVAVTLTTMVYIYHNRYPTLGEISCWFRTEREQSYFVYLPLSVMLSINIFLFVWTSLHLHASGDDLSPDRKKSLRYKCMLYLKLFLLSGLIWIFEILSFHMSEGLVPQSWFWIIVDAINCLHGVLIFFVLIVWRQRIKRELANRWVFCFRAPARWAELKDDEQEHLHEEGRDTGKYDLIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4B1</accession>
    <name>A0A182P4B1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4B1"/>
    <dbReference type="STRING" id="199890.A0A182P4B1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001747-RA">
        <property type="protein sequence ID" value="AEPI001747-PA"/>
        <property type="gene ID" value="AEPI001747"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001747"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001747-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="139" mass="15393" checksum="290D3FFE161CF752" modified="2016-09-07" version="1">MADNFGIHRGTGKKALEMAEDRSQGQILSDFMMQLEDYTPTIPDAVTSYYLNSAGFEGADPRIVRLISIAAQKFVSDVANDALQHCKTRTNSAPSSGHGSSKNQNQKSSKDRKYTLTMEDLQPALNDYGITVRKAHYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4F6</accession>
    <name>A0A182P4F6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4F6"/>
    <dbReference type="STRING" id="199890.A0A182P4F6"/>
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        <property type="protein sequence ID" value="AEPI001792-PA"/>
        <property type="gene ID" value="AEPI001792"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001792"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="ASAP"/>
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        <property type="entry name" value="ASAP1-like_SH3"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854:SF3">
        <property type="entry name" value="ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ASAP FAMILY MEMBER"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3"/>
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    <proteinExistence type="predicted"/>
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            <end position="66"/>
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            <begin position="512"/>
            <end position="576"/>
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            <begin position="107"/>
            <end position="288"/>
        </location>
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            <end position="501"/>
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            <end position="199"/>
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            <end position="472"/>
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        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001792-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="576" mass="61402" checksum="4E072B8B726941F8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4G5</accession>
    <name>A0A182P4G5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4G5"/>
    <dbReference type="STRING" id="199890.A0A182P4G5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001801-RA">
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        <property type="gene ID" value="AEPI001801"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001801"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130835" evidence="2">
        <location>
            <begin position="19"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001801-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="316" mass="35570" checksum="C518A1D1E430B571" modified="2016-09-07" version="1">PSVVFSLLVAHLAHANLAAESTVTSAKLINAPPPLSTTSLGSLYRSARDDYNSRRHCSNCGTGYERDMRSYGRQTGITGYYSGMGPIEDDRNWYYRPESFEDRYRGGGMQASYSGAYRQSPYMGYEYDRYMHRPDDRGYGYGYPAMIMRAGFYDGSVSRMPYYPEMLRGYGYRGNGYDNLDPHYEYYMTQRGGGSPIGMSNRDRVYGNHGIYDDRMGYGGQYDQKNFRPWDQTYSVAYGGRPRPASLGDTSYLMDRDNHLDNQVSLSQDSKGSSDDNSDIRAKLDSETGASEIPKHKDGTAESADSSDTENKTPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4I7</accession>
    <name>A0A182P4I7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4I7"/>
    <dbReference type="STRING" id="199890.A0A182P4I7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001823-RA">
        <property type="protein sequence ID" value="AEPI001823-PA"/>
        <property type="gene ID" value="AEPI001823"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001823"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11057">
        <property type="entry name" value="CYP313-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001823-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="504" mass="58030" checksum="5F997DA4705F0AD3" modified="2016-09-07" version="1">MIVLVFVGVFALVYYLNFRRSRKRLYALAERIPGPFDYPLIGSIWLTIGKSPLEMVTHLMELMHHLPSPMRAWLGPFLLIVIDRPEMVQDILSSPDCVQKPFMYDFFRLSKGLFGAPATLWKRHRKLLNTSFSPAVLKSFVPTLNAKAAQFSQELEGQASGECFDVHTLLARYTLVTISSTTFGADLSVEKREVLEEYSSNAIQMFTNCFERIYKAWLHPEPIYRLTAAFREEEMRLKIFKRMSKKIMAMRQALVPRKPKDEQQQQQDSDPEDNQEFPKAKIFIERLEEIAQDPANGIDEDGFQQHIDTMLFGGNDTSAQALANTLLTLGMYPDWQERVYQEIMDVAPSGPISYDDLSKLTCMEMFLKETIRLLPITGLVARAPVKEVQAQHITVPSGAIVLIPLLKMHRDKAIWGPDAEQFNPDNFLPERCAERHPYAFIPFSQGPRNCIGMKYGWISMKVLLCHVVRRYRIATDIKLRDIKLSLSLVMKLNTKHLIRLERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5H0</accession>
    <name>A0A182P5H0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="6 16">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="6 16"/>
    <dbReference type="AlphaFoldDB" id="A0A182P5H0"/>
    <dbReference type="STRING" id="199890.A0A182P5H0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002160-RA">
        <property type="protein sequence ID" value="AEPI002160-PA"/>
        <property type="gene ID" value="AEPI002160"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002160"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002160-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="415" mass="43871" checksum="D244BDCA9392E516" modified="2016-09-07" version="1">MALNKLSIENVDLKDKRVFMRVDFNVPIKEGKITSNQRIVAALDSIKFALEKGAKSVVLASHLGRPDGNKNTKYTLAPVADELKKLLGRDVTFLNDCVGAEVEAACKDPAPGSVILLENVRFYVEEEGKGVDASGNKVKADKDKVKTFRESLAKLGDVYVNDAFGTAHRAHSSMMGEGYSQRAAGLLLNKELRYFSQALDNPPRPFLAILGGAKVADKIQLIENLLDKVNEMIIGGGMAFTFLKVLNNMEIGGSLFDAEGAKIVQNLVDKAKKNNVQLHLPVDFVTGDKFAEDAATGEATVAGGIPAGHMGLDIGPKSREAFAAPIARAKIIVWNGPPGVFEFPNFANGTKSLMDGVVAATKAGTVSIIGGGDTASCCSKWGTESQVSHVSTGGGASLELLEGKVLPGVDALSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5N7</accession>
    <name>A0A182P5N7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5N7"/>
    <dbReference type="STRING" id="199890.A0A182P5N7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002228-RA">
        <property type="protein sequence ID" value="AEPI002228-PA"/>
        <property type="gene ID" value="AEPI002228"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002228"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002228-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="78" mass="8664" checksum="0960576E882FD7B9" modified="2016-09-07" version="1">MEIYDQQTYALLANVSSKLPIFTVNGLDAGLLLKIVIYATNMRGRSEPILLQAYTLKAAEKQTVHKLSRRAVDNGAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5S1</accession>
    <name>A0A182P5S1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5S1"/>
    <dbReference type="STRING" id="199890.A0A182P5S1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002262-RA">
        <property type="protein sequence ID" value="AEPI002262-PA"/>
        <property type="gene ID" value="AEPI002262"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002262"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130937" evidence="2">
        <location>
            <begin position="25"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002262-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="717" mass="78149" checksum="8B81BC2866978BD8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5W8</accession>
    <name>A0A182P5W8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NLGase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5W8"/>
    <dbReference type="STRING" id="199890.A0A182P5W8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002309-RA">
        <property type="protein sequence ID" value="AEPI002309-PA"/>
        <property type="gene ID" value="AEPI002309"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002309"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000041">
        <property type="entry name" value="Non-lysosomal glucosylceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024462">
        <property type="entry name" value="GH116_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052566">
        <property type="entry name" value="Non-lysos_glucosylceramidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654">
        <property type="entry name" value="BILE ACID BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654:SF0">
        <property type="entry name" value="NON-LYSOSOMAL GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Six-hairpin glycosidases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl-hydrolase family 116 catalytic region" evidence="2">
        <location>
            <begin position="319"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002309-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="87719" checksum="6E231CD2F8515D8D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5Y8</accession>
    <name>A0A182P5Y8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein osiris 24</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5Y8"/>
    <dbReference type="STRING" id="199890.A0A182P5Y8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002329-RA">
        <property type="protein sequence ID" value="AEPI002329-PA"/>
        <property type="gene ID" value="AEPI002329"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002329"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF25">
        <property type="entry name" value="OSIRIS 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131015" description="Protein osiris 24" evidence="2">
        <location>
            <begin position="29"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002329-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="44698" checksum="459A45D5F05BC1DF" modified="2016-09-07" version="1">MVTIRQLSRPMALGTIVMLVMAIHQARAATSKNQTTSSQPNELVQLEDALTDYIGDWFSRNSRDLIGSALVGTSSGSGSGNASSSLSHFDRTVIKGVARLLGTAVDSVQSRTTEKSPEAGRLFLFKGMKKLLWPVMIGLQIVKTVLIMMFLPSIIGSLGKIVGKGLSSVSGLSHPAQTVDDLDFKDTTSYNADHDFGMNDGNGYLPADDTHASGTSYNSYVYDPASMGAHTNAANALSRLGYGGGRVTYVGPSMVQAANRRKQQSAKNDFKIFHDIPSSSLLLTNYDPFYSPLLSRLDAIFAQMGLSNKEEQCRQRLVCLMYANPAKYAPYSNLISAQLSRELDELRKPTNDNPDILRFFKYMRAAKDGQDGVDCDAHYKDCTGYKDLSNPAMVTTFNDINKLVHARKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P683</accession>
    <name>A0A182P683_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P683"/>
    <dbReference type="STRING" id="199890.A0A182P683"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002431-RA">
        <property type="protein sequence ID" value="AEPI002431-PA"/>
        <property type="gene ID" value="AEPI002431"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002431"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF2">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002431-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="458" mass="52919" checksum="E7EE26D75F22E601" modified="2016-09-07" version="1">MDSEYRNFHPNKCNVCFQQSSTKPSTSTTGAPLQPCRKCKLIKYCSKNHQLYDAPTHKPFCMAVQSILQKSGTDHVLRCAESFLGIQFKANPVDMVAFMNLVKCTSLLVSKILNRPLMHHEHMMLTFPSLCNVCMEYRPEKLFVCANCNQVAYCSKEHQESDRKKHSKWCDRLRINFFFDTDISNNSSIGAFPKFAFENEETFQNTFPKDIFELASTALEVEVKSSATEPGLELAEELHNISIAGMFSHVGTILYVMRALGMFEEVDNELRVYILGAEKDHVFFNAFTNTVLFRFLPKLRRLRLFFIGPNVDKAAESVMHFSDNRIIEIEMHRYVFHKIPEKVKLPEAHLAIAFNSGFNEFYGSKKYTWEETLRRILKKPNLAFAFTSYTLGEAMDDASIMELTEQRLPSFHNLVFMRRNIVNPFRNPVPIRNPNQADENDVLYYENGYLSICVMRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6E4</accession>
    <name>A0A182P6E4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(i/o/t/z) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6E4"/>
    <dbReference type="STRING" id="199890.A0A182P6E4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002492-RA">
        <property type="protein sequence ID" value="AEPI002492-PA"/>
        <property type="gene ID" value="AEPI002492"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002492"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032291">
        <property type="term" value="P:axon ensheathment in central nervous system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060857">
        <property type="term" value="P:establishment of glial blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007419">
        <property type="term" value="P:ventral cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002487">
        <property type="entry name" value="Guanine nucleotide-binding protein G(i) subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF227">
        <property type="entry name" value="G PROTEIN ALPHA I SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="914"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="673"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="144"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="169"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="238"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002492-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="991" mass="110177" checksum="36ACB08D9DD91C83" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6M0</accession>
    <name>A0A182P6M0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6M0"/>
    <dbReference type="STRING" id="199890.A0A182P6M0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002568-RA">
        <property type="protein sequence ID" value="AEPI002568-PA"/>
        <property type="gene ID" value="AEPI002568"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002568"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061138">
        <property type="term" value="P:morphogenesis of a branching epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18489">
        <property type="entry name" value="BACK_BTBD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18283">
        <property type="entry name" value="BTB1_POZ_BTBD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18284">
        <property type="entry name" value="BTB2_POZ_BTBD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042345">
        <property type="entry name" value="Btbd7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047936">
        <property type="entry name" value="BTBD7_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047934">
        <property type="entry name" value="BTBD7_BTB_POZ_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047935">
        <property type="entry name" value="BTBD7_BTB_POZ_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16064">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16064:SF3">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="223"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="327"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002568-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1232" mass="132216" checksum="A47AAE9DEF04D0CF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P774</accession>
    <name>A0A182P774_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P774"/>
    <dbReference type="STRING" id="199890.A0A182P774"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002776-RA">
        <property type="protein sequence ID" value="AEPI002776-PA"/>
        <property type="gene ID" value="AEPI002776"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002776"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="4">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002776-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="206" mass="22447" checksum="2A8571FA07CF32BC" modified="2016-09-07" version="1">MCIVFFEPTDMRIADRPFAARNPKLAALAARAIKFISPNVHELAQIAQALHYPGPIPAKAMDEYCTLGELLDDVQPLARFVNETIDHVLVTLGHHGVAVFRRTPPTVPFFGPAHEYQPVPSDRPTGRFYPAPELPQIVNVSGAGDSFTSGFIVAALAGRPEPVCVNVALEAAGCALRARSAVAERYFDRAHPCWTNEQGAAYRTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P777</accession>
    <name>A0A182P777_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P777"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002779-RA">
        <property type="protein sequence ID" value="AEPI002779-PA"/>
        <property type="gene ID" value="AEPI002779"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002779"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002779-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="227" mass="24623" checksum="F07AC59071F8F4EE" modified="2016-09-07" version="1">MKQNSAKPTTVPSSKAGSRASGQHGHHHHQQHQSQQQMHSYHQQQMQQPAAVTFQQQPSYLQAPQHHQLQQPGCIVLPSGATPLQPQQPTYMMHQQSGMRPNAGTGIGPTMYVGAPMVQQTSQQAGPTGFSTPSGYLQATAPLQPSMTQVLQQRPNSCQPTVTDFVAGSGAVTAGYSDAHQPYKQSAQQTQLMQPYQEGPSSSYPIHMQSSPHPDGSTTEAHYFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7K0</accession>
    <name>A0A182P7K0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7K0"/>
    <dbReference type="STRING" id="199890.A0A182P7K0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002903-RA">
        <property type="protein sequence ID" value="AEPI002903-PA"/>
        <property type="gene ID" value="AEPI002903"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002903"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000005">
        <property type="entry name" value="Carboxypeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000001">
        <property type="entry name" value="Carboxypeptidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130908" description="Peptidase M14 domain-containing protein" evidence="12">
        <location>
            <begin position="27"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="13">
        <location>
            <begin position="153"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002903-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="449" mass="50427" checksum="4ED52BDC95E5EF75" modified="2016-09-07" version="1">MKQTYSSRISAMWFVLLAALACCCTANKLPAVASTSDQSQPAVRNDATAITQPVKYDGAQLWRIAYDDQPKKNAVAELQDRFEASMWNYNATSVDIFVRGQSIKKAECFLRAANIPYEVVIEDMQRAIDTENPSLEETELWENRNGHRMTWTAYHRLADIYDWMDYLAQTYPDLCSTKAIGKTVQGRELKVLRISNGNPSNKAIWMDGGIHAREWISPATVTFIANELIEDWDNQPDHLRNVDWYILPVHNPDGYEHSHQYDRLWRKNRGGLQYGPCAGVDLNRNYGYKWGGQGTSKQPCSEIFAGSGPFSEPETKAVSEFMQSSAANWRGFLTFHSYGQYILYPWGYDRVVPPDHADLKRVGDAAAEQMLQASGGSRYTVGPSGSTLYPAAGGSDDWARAALNIKYAYTVELRDTGRYGFVLPASQIKPTGDEAFTFVDVIAQEVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8N2</accession>
    <name>A0A182P8N2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8N2"/>
    <dbReference type="STRING" id="199890.A0A182P8N2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003285-RA">
        <property type="protein sequence ID" value="AEPI003285-PA"/>
        <property type="gene ID" value="AEPI003285"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003285"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15136">
        <property type="entry name" value="7tmA_Glyco_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000156">
        <property type="entry name" value="Lutropin-choriogonadotropic hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF82">
        <property type="entry name" value="RICKETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="705"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="556"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="939"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="988"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1091"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="948"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="994"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1017"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003285-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1143" mass="127874" checksum="51DE908D66D21FA2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8Y9</accession>
    <name>A0A182P8Y9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8Y9"/>
    <dbReference type="STRING" id="199890.A0A182P8Y9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003393-RA">
        <property type="protein sequence ID" value="AEPI003393-PA"/>
        <property type="gene ID" value="AEPI003393"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003393"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002142">
        <property type="term" value="C:stereocilia ankle link complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000219">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF36">
        <property type="entry name" value="HARMONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="62"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="195"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="665"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003393-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="711" mass="75996" checksum="54C19D3E0C8DDE0D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9X9</accession>
    <name>A0A182P9X9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9X9"/>
    <dbReference type="STRING" id="199890.A0A182P9X9"/>
    <dbReference type="ESTHER" id="anost-a0a182xzf1">
        <property type="family name" value="Pancreatic_lipase"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="AEPI003733-RA">
        <property type="protein sequence ID" value="AEPI003733-PA"/>
        <property type="gene ID" value="AEPI003733"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003733"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000033">
        <property type="entry name" value="Pancreatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000028">
        <property type="entry name" value="Triacylglycerol lipase, pancreatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002331">
        <property type="entry name" value="Lipase_panc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00823">
        <property type="entry name" value="PANCLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131104" description="Lipase domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="50"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003733-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="554" mass="61867" checksum="02EEDEDDD81C5701" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA52</accession>
    <name>A0A182PA52_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Methionyl-tRNA synthetase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PA52"/>
    <dbReference type="STRING" id="199890.A0A182PA52"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003806-RA">
        <property type="protein sequence ID" value="AEPI003806-PA"/>
        <property type="gene ID" value="AEPI003806"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003806"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000022">
        <property type="entry name" value="Methionyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003806-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="561" mass="64660" checksum="FD29891E8EA54B5D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBD7</accession>
    <name>A0A182PBD7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C-terminal binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBD7"/>
    <dbReference type="STRING" id="199890.A0A182PBD7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004242-RA">
        <property type="protein sequence ID" value="AEPI004242-PA"/>
        <property type="gene ID" value="AEPI004242"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004242"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000012">
        <property type="entry name" value="C-terminal-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF7">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="34"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="130"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004242-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="49139" checksum="7E160D13B9F86868" modified="2016-09-07" version="1">MMPKRSRLGDVRGPISNGPMQSRPLVALLDGRDCSIEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVRDAAQGCARIRGDTLGLVGLGRIGSAVALRAKVFGFNVSFYDPYLPDGIEKSLGLNRVYTLQELLFHSDCVSLHCTLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEALAVALKQGRIRAAALDVHENEPYNGALKDAPNLLCTPHAAFYSEAATTELREMAASEIRRAIIGNIPECLRNCVNKEYFMRSSTGGGAGGYSEAGINGGYYSGGLQQAHSTTPLEAPHSAGSHAPPSGGGPPPPPVTVMPPVSAVTAPPPQGIMLPPSFSETTTTIYYNYCPISTPPPPSPPNLRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBE2</accession>
    <name>A0A182PBE2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBE2"/>
    <dbReference type="STRING" id="199890.A0A182PBE2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004247-RA">
        <property type="protein sequence ID" value="AEPI004247-PA"/>
        <property type="gene ID" value="AEPI004247"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004247"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050686">
        <property type="term" value="P:negative regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000205">
        <property type="entry name" value="Sex lethal, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="85"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="171"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004247-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="282" mass="31593" checksum="16E56D67F0AAD2FD" modified="2016-09-07" version="1">MMVSIVFGSNYLQDADFSSYSRPRLYGDMPSSSTFGGGNPSTPHHHHHHHHHLSQPPSHHHTSSSSTSSLTGMNFGPGSSGTAGTNLIVNYLPQDMTEREMYSMFSAMGPIESCRLMRDLKTGYSYGFGFVNYLNEDAAQRAIKCLNGYPLRNKRLKVSYARPQSDDIKETNLYITNLPRTITEEQLDIIFGKYGTIVQKNILRDKLTGQPRGVAFVRFNKREEAQEAISALNNVIPQGGNQPLIVRVAEDHGRAKAALYVPSYNSIVHNNRGRVRMRNTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBE4</accession>
    <name>A0A182PBE4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GAS2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBE4"/>
    <dbReference type="STRING" id="199890.A0A182PBE4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004249-RA">
        <property type="protein sequence ID" value="AEPI004249-PA"/>
        <property type="gene ID" value="AEPI004249"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004249"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904825">
        <property type="term" value="P:protein localization to microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.20:FF:000004">
        <property type="entry name" value="GAS2-like protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF18">
        <property type="entry name" value="GAS2-LIKE PROTEIN PICKLED EGGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="6">
        <location>
            <begin position="203"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="602"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="811"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="658"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="817"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004249-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="873" mass="93125" checksum="DC009A05235E3C73" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBK3</accession>
    <name>A0A182PBK3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C19orf12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBK3"/>
    <dbReference type="STRING" id="199890.A0A182PBK3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004308-RA">
        <property type="protein sequence ID" value="AEPI004308-PA"/>
        <property type="gene ID" value="AEPI004308"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004308"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033369">
        <property type="entry name" value="C19orf12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31493">
        <property type="entry name" value="NAZO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31493:SF1">
        <property type="entry name" value="PROTEIN C19ORF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20721">
        <property type="entry name" value="C19orf12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004308-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="140" mass="14834" checksum="E8FBF19C7A87629D" modified="2016-09-07" version="1">MTINTRELLDAVATLTDKESMRVTLKSSAKGATVAGSSTFLGGLLAGPIGLFIGGALGGLVAYAMTNGQFKPVSHIIRYDLSAPEQERLKQRVMDALSEFQATDMIMILPLLTGSASAQQAVLGAVVSFLTNEMRMQIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC08</accession>
    <name>A0A182PC08_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CBF-beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC08"/>
    <dbReference type="STRING" id="199890.A0A182PC08"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004464-RA">
        <property type="protein sequence ID" value="AEPI004464-PA"/>
        <property type="gene ID" value="AEPI004464"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004464"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016513">
        <property type="term" value="C:core-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.250.10">
        <property type="entry name" value="Core binding factor, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003417">
        <property type="entry name" value="CBF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036552">
        <property type="entry name" value="CBF_bsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10276:SF3">
        <property type="entry name" value="CORE-BINDING FACTOR SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10276">
        <property type="entry name" value="CORE-BINDING FACTOR, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02312">
        <property type="entry name" value="CBF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50723">
        <property type="entry name" value="Core binding factor beta, CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004464-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="90" mass="10722" checksum="07E107AC5CEB05E4" modified="2016-09-07" version="1">MNGVCVRFRGWLDMERLDGIGCLEMDEKRAAQEDAILREQLERYNQRLRDFEDKQRTYQRNTQDEFEQMRRNQSGMGVSVTAGASGMWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC87</accession>
    <name>A0A182PC87_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC87"/>
    <dbReference type="STRING" id="199890.A0A182PC87"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004542-RA">
        <property type="protein sequence ID" value="AEPI004542-PA"/>
        <property type="gene ID" value="AEPI004542"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004542"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001215">
        <property type="entry name" value="AGAP011680-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF96">
        <property type="entry name" value="FACILITATED TREHALOSE TRANSPORTER TRET1-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004542-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="487" mass="52906" checksum="336E71D93522B647" modified="2016-09-07" version="1">MAALKQTLLSLSVSLSYYCIGLVRGYSAPAVPSMHATVPDLLPTKNIASWVSSIPPFGAFFGSLVAFPLMHRIGRKYTVLIASPLWVTSWILIATAHDWRVLFVSRMLSGFGAGLSLPAAQVYVSECSDPRIRGVIGSLPALAMSFGILVMYIMGKFFHWRVLAWICCGMASCLFLAVACFPQSPVWLKTRKQYEKAHYSAKWLHLQGFAIDPKATTAVVEQKEQPQPASAPKPFSKEALIRREILIPLGIGLVLLSIQQLSGIDAVVFFTVEIFHAAGSSMDGHLATIIVGTVQVLSNGAALFVVDRAGRKPLLIMSGLIMCIAMASMGAAFHLNSIGNTCFGYLPVVSLIVFMIGFSIGFGSIPFLLMGELFPTAQRSLLSSLAGSFNLAMMFTVIKTYHPLEDLITTSGTFLMYSVLCALGVVFVITCVPETKGRELESIQKLFERQPQPCSQQELGSEKVSHDNAGFSATDETVQSRSIDTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCB9</accession>
    <name>A0A182PCB9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Adenosine deaminase-like protein</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PCB9"/>
    <dbReference type="STRING" id="199890.A0A182PCB9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004574-RA">
        <property type="protein sequence ID" value="AEPI004574-PA"/>
        <property type="gene ID" value="AEPI004574"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004574"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00443">
        <property type="entry name" value="ADA_AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000033">
        <property type="entry name" value="Adenosine deaminase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000343">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="18">
        <location>
            <begin position="215"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004574-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="544" mass="61319" checksum="69194C1133F8742C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD39</accession>
    <name>A0A182PD39_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 93</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC93 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PD39"/>
    <dbReference type="STRING" id="199890.A0A182PD39"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004844-RA">
        <property type="protein sequence ID" value="AEPI004844-PA"/>
        <property type="gene ID" value="AEPI004844"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004844"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039116">
        <property type="entry name" value="CCDC93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019159">
        <property type="entry name" value="CCDC93_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048747">
        <property type="entry name" value="CCDC93_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16441:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16441">
        <property type="entry name" value="FIDIPIDINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09762">
        <property type="entry name" value="CCDC93_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21673">
        <property type="entry name" value="CCDC93_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC93 coiled-coil" evidence="6">
        <location>
            <begin position="205"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="275"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004844-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="565" mass="65860" checksum="33696467F8495266" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD59</accession>
    <name>A0A182PD59_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PD59"/>
    <dbReference type="STRING" id="199890.A0A182PD59"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004864-RA">
        <property type="protein sequence ID" value="AEPI004864-PA"/>
        <property type="gene ID" value="AEPI004864"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004864"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF47">
        <property type="entry name" value="GH22833P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="153"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004864-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="458" mass="52115" checksum="28A38D66040097F3" modified="2016-09-07" version="1">MPSQPAIMKEQMAVGVYVDDDRDVYMIERKDTIVDIVRMQQEAGLWQTLSVDLVDCGPGSREGDNYMSIIKRVKAHCKAKSVDGRNHVFTISLIFKRQITNPNRRRLFRCDAAFENEINAYASIVPVLQRISPYDLPYPKCVTAGADDYGDRIVLEDLTTSGYAMVDRRVGLSYDHCAAVMKELAKLHAVSLAMKHAQPTEYGEVCGKIREIVYCPEAAEFYTHSLESSLRGALESLRYSNNDGDLDGPIRAMEALTGRLYRIMSGLVCNGMDEGWRVICHGDTWVNNLMFSADGQHVRLIDLQTMRCTTPVLDILHLLYTSTEHEMRQQNVTELLLQYRRSLLAALNEHFCAFGEPGPAATLLRRYAEQFSYQRLRAEYDRCLPYGLGIAMWLLPAVTFNPDQIPDLDAVTINDFKTKKHDKRIAQMVSADYHARMRDIVLEMYDQGVLQRLKSECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD73</accession>
    <name>A0A182PD73_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear lamin L1 alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PD73"/>
    <dbReference type="STRING" id="199890.A0A182PD73"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004878-RA">
        <property type="protein sequence ID" value="AEPI004878-PA"/>
        <property type="gene ID" value="AEPI004878"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004878"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004878-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="70044" checksum="A2C11CF5EAF3964F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDB9</accession>
    <name>A0A182PDB9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDB9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004924-RA">
        <property type="protein sequence ID" value="AEPI004924-PA"/>
        <property type="gene ID" value="AEPI004924"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004924"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004924-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="129" mass="13817" checksum="3E5F3B698D6EEBC3" modified="2016-09-07" version="1">MFPCLSETKVETDAAENEKDSTTEKTNKEGGDGGGGDTSVAAVSPTSDGESDANNKTLENGSNDESLNDSKAQAAAAGDDANKKAKKPKKKWSFRSLSFSKKDKQKPAKKEKDEERVNGECEKVPEEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDL7</accession>
    <name>A0A182PDL7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDL7"/>
    <dbReference type="STRING" id="199890.A0A182PDL7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005022-RA">
        <property type="protein sequence ID" value="AEPI005022-PA"/>
        <property type="gene ID" value="AEPI005022"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005022"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07661">
        <property type="entry name" value="BAR_ICA69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000068">
        <property type="entry name" value="Islet cell autoantigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024114">
        <property type="entry name" value="Islet_autoAg_Ica1/Ica1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006723">
        <property type="entry name" value="Islet_autoAg_Ica1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164:SF4">
        <property type="entry name" value="GH23156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164">
        <property type="entry name" value="ISLET CELL AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04629">
        <property type="entry name" value="ICA69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01237">
        <property type="entry name" value="ICA69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="2">
        <location>
            <begin position="31"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005022-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="500" mass="54769" checksum="E2053415FC82B700" modified="2016-09-07" version="1">MLTSEFQHQFWVTKKAVQRKLGTKEDENIVASDGELDSKIELFRSVAESCSKLYRIIDQYQERVCILAQEENSLGKFLREVSKESPTTGKMMSTTGKAISYCGQQRIAIRVPLLRLHHDVHTFKGRAIADTHHTIQLMEKERTEYRAALSWMKSVSIQLDPDTGRGLEKFRKAQRHVKTAKTKFDKYTLDCLEKIDLLAAARCNMFSHALVGYQNAILQFAKKTDETYKNTLKSLAKDPHYSFSILKELTQANPNEEEKEGVSEEMVENQPTNESTDDDQMLFFKDDYKDDVGSLKNAEQTTGKGKENILKDVALEIDALLSGVPELSLNPASNTSPATNPTEASGTDLLGLSLDDEFSDFMSAPAPFLPSALLTNCTLTDDGGFDFSSSLSENDPLPALQQTAGELLANDTSNSKSSEKATDIFSSLLQSFSKQGSATAGNSSDGSTGAAKQGKATGGSSKTAGKDLSGWYQLFAELDPLSNPDAIPSKSDAPNNSMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEC8</accession>
    <name>A0A182PEC8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIX1-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LIX1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEC8"/>
    <dbReference type="STRING" id="199890.A0A182PEC8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005283-RA">
        <property type="protein sequence ID" value="AEPI005283-PA"/>
        <property type="gene ID" value="AEPI005283"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005283"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029270">
        <property type="entry name" value="LIX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF6">
        <property type="entry name" value="PROTEIN LIMB EXPRESSION 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14954">
        <property type="entry name" value="LIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005283-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30245" checksum="03A6275C514AA14E" modified="2016-09-07" version="1">MMVYPEEPIWSFPHIPALYDDGDYGVNVVEALQEFWQMKAARGADLKNGALVIYESIPSTSQPYVCYVTLPGGSCFGSFQNCPTKAEARRSSAKIALMNSVFNEHPSRRISDDFIEKAVTEARASFKGDQNQEDDGPDTGIGAFRFMLETNKGRTMLEFQELMTVFQLLHWNGSLKAMRERQCSRQEVVAHYSNRSLDDEMRQQMALDWIEREHENPGLLSRELAIAERELETARLAGRELRFPKEKKDILQMAHNQLTGGSNINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEU4</accession>
    <name>A0A182PEU4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alkaline phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182PEU4"/>
    <dbReference type="STRING" id="199890.A0A182PEU4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005449-RA">
        <property type="protein sequence ID" value="AEPI005449-PA"/>
        <property type="gene ID" value="AEPI005449"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005449"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF85">
        <property type="entry name" value="ALKALINE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005449-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="272" mass="29262" checksum="EC633C0486931063" modified="2016-09-07" version="1">MPNHDRVLVDNTLNVGTQNELASLDTSKIDYLLGLFDYDHLPFSSDIADGSVTPALVRMVHYSLEMLQKKEHTNGFLLFVEDGNIQRAHAQNKPRKAFEQVRHYANAFNMAHMMANEQNTLFISMNDVGSTLTLPGYPARSSDLVDTSAGTSAADGLPYLGVSYATGPAHSTYYRTGTGRVDPMEVLQGVSNMHERTCPAMVPMVEGADGGEDAAVYASGPWAFMLSGGYEQHFVAHTIAFASCMDGACDGAATLVLSTATLLAAVGARLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF48</accession>
    <name>A0A182PF48_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/potassium-transporting ATPase subunit beta-1-interacting protein</fullName>
            <shortName evidence="7">Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein</shortName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NKAIN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PF48"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005553-RA">
        <property type="protein sequence ID" value="AEPI005553-PA"/>
        <property type="gene ID" value="AEPI005553"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005553"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008516">
        <property type="entry name" value="Na/K-Atpase_Interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13084:SF6">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13084">
        <property type="entry name" value="T-CELL LYMPHOMA BREAKPOINT-ASSOCIATED TARGET 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05640">
        <property type="entry name" value="NKAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005553-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="165" mass="19059" checksum="3931A05B8E6F905C" modified="2016-09-07" version="1">MHCGEALFLIERQVFDFLGFMWAPILVNFFQILFVIFGFFGAYQYRPRYIVAYTVWSLLWLGWNIFLICFYLNVGILDRDSDLLNLGTGSVSWFEENGYGCRPTYPTNITFEDPFRPIRPERVDGCLLEYHIVEVVHSGVHCALAVFGIFGAICLGHTFLDEDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFS9</accession>
    <name>A0A182PFS9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epidermal growth factor receptor substrate 15-like 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PFS9"/>
    <dbReference type="STRING" id="199890.A0A182PFS9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005786-RA">
        <property type="protein sequence ID" value="AEPI005786-PA"/>
        <property type="gene ID" value="AEPI005786"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005786"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF176">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE CLONE 15, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="126"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="296"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="724"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="792"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1146"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005786-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1186" mass="126968" checksum="D56445BB84F25091" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFV9</accession>
    <name>A0A182PFV9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PFV9"/>
    <dbReference type="STRING" id="199890.A0A182PFV9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005818-RA">
        <property type="protein sequence ID" value="AEPI005818-PA"/>
        <property type="gene ID" value="AEPI005818"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005818"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00503">
        <property type="entry name" value="Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000002">
        <property type="entry name" value="Frataxin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005818-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="208" mass="23534" checksum="B6FD823AB13F7337" modified="2016-09-07" version="1">MNYMLRPIVGRWGGRLISCTHTLDPAVMPCCNRLSREPVEAIVSKRSCNLRFSRPYSSMNPNDFIATSLIDSVTFVAVCSDTLESLVDYFEQIVDETNTLKNPDVTYGDGVLTVSFGEPHGTYVINRQLPNRQIWLSSPTSGPKRYDFIPDKRTVNEGYWLYRHDGVTLHELLQREISAIVGRELAFFDLPHSQRPQEPVAPADGRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PG10</accession>
    <name>A0A182PG10_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PG10"/>
    <dbReference type="STRING" id="199890.A0A182PG10"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005869-RA">
        <property type="protein sequence ID" value="AEPI005869-PA"/>
        <property type="gene ID" value="AEPI005869"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005869"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005869-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="788" mass="83010" checksum="B25CB7A891E0E93C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGD3</accession>
    <name>A0A182PGD3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 234 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGD3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005992-RA">
        <property type="protein sequence ID" value="AEPI005992-PA"/>
        <property type="gene ID" value="AEPI005992"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005992"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005992-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13503" checksum="5B68574EF79BED1B" modified="2016-09-07" version="1">MDSPEELAPAASVDIYAMLSILLVALMWGATNPFIKRGSIGYNELKANSKLGQLWLEVRFLISRWQYLLPLLINQLGSVAYVLTLQRTELSLTVPMANSLTFVFTAITARLLGERQSGWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGW2</accession>
    <name>A0A182PGW2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">P-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGW2"/>
    <dbReference type="STRING" id="199890.A0A182PGW2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006171-RA">
        <property type="protein sequence ID" value="AEPI006171-PA"/>
        <property type="gene ID" value="AEPI006171"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006171"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017957">
        <property type="entry name" value="P_trefoil_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF167">
        <property type="entry name" value="LYSOSOMAL ALPHA-GLUCOSIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57492">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00025">
        <property type="entry name" value="P_TREFOIL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="10">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006171-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="927" mass="104513" checksum="8249336E70892511" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGX9</accession>
    <name>A0A182PGX9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGX9"/>
    <dbReference type="STRING" id="199890.A0A182PGX9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006188-RA">
        <property type="protein sequence ID" value="AEPI006188-PA"/>
        <property type="gene ID" value="AEPI006188"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006188"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18234">
        <property type="entry name" value="BTB_POZ_KLHL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF450">
        <property type="entry name" value="KELCH-LIKE PROTEIN DIABLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="66"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006188-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="675" mass="73944" checksum="EF2E41B578FC7248" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHB3</accession>
    <name>A0A182PHB3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHB3"/>
    <dbReference type="STRING" id="199890.A0A182PHB3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006322-RA">
        <property type="protein sequence ID" value="AEPI006322-PA"/>
        <property type="gene ID" value="AEPI006322"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006322"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19116">
        <property type="entry name" value="AKR_AKR2E1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000023">
        <property type="entry name" value="aldose reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044488">
        <property type="entry name" value="AKR2E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006322-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="325" mass="36626" checksum="3A574EF5945F39A9" modified="2016-09-07" version="1">MAPKVPNVRLNNGLEMPMLGLGTYLATEEEGIAAVKMAIDEGYRHIDTAYFYQNENQVGQAVRAKIAEGLIKREDVFIVTKVWNTYHAPEHVAEACQKSLDNLGLDYIDLYLIHWPMGWKFAGWSADDLMPMDANGKSIVSDVDYLDTWKAMEALVKEGKVKSIGVSNFNSKQLTRLLGNCEIKPVTNQVEVNPAINQRKLIEFCRQHDIVITAYSPLGRPNMADPVVGTAGIPKHALDDPRVIEIGKKYGKTAGQVVLRYLIELGTLPIPKSSKLERIRQNIDIFDFKLTEEEIKVMDGFNTGGRTVPFNFSSEHKYFPFKEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI29</accession>
    <name>A0A182PI29_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myofilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PI29"/>
    <dbReference type="STRING" id="199890.A0A182PI29"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006591-RA">
        <property type="protein sequence ID" value="AEPI006591-PA"/>
        <property type="gene ID" value="AEPI006591"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006591"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031828">
        <property type="entry name" value="Myofilin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15929">
        <property type="entry name" value="Myofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006591-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="18399" checksum="DAAB54A8720EC92C" modified="2016-09-07" version="1">MFKNHLAMIGMNETPNKKAKFWQSYIRSLKGSDDIRAHDTPAYRRPILLFDEPDTAVGRINSPGYHYLPVHRETYGYSPRPIYDHHYTRSQRAPSVNRLADAEKAWADHLERMREIDRRYPSRYGLYLKDKPSQVVFPQEMEYEPETKPLYSTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI55</accession>
    <name>A0A182PI55_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Symplekin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PI55"/>
    <dbReference type="STRING" id="199890.A0A182PI55"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006617-RA">
        <property type="protein sequence ID" value="AEPI006617-PA"/>
        <property type="gene ID" value="AEPI006617"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006617"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="117"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="6">
        <location>
            <begin position="920"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1151"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006617-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1183" mass="133733" checksum="CB6A85089676264D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI99</accession>
    <name>A0A182PI99_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PI99"/>
    <dbReference type="STRING" id="199890.A0A182PI99"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006661-RA">
        <property type="protein sequence ID" value="AEPI006661-PA"/>
        <property type="gene ID" value="AEPI006661"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006661"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF494">
        <property type="entry name" value="GH04538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="11"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006661-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="412" mass="45368" checksum="BFC133D9AAD5C46B" modified="2016-09-07" version="1">MCRIPPRNTLGTFVHVMKSALGIGILSVPYAFKHGGLVFGVLGAFFFAMLCSHSAHILVSTSYKICKKERIPVLGFAETVEKACANGSAGVRALGTALRNIIDWYLMLTTVVVFIVFVGTTLREVVNYRTGWDWSDRTYILLVGVPILLITQIREIKYLVPFSAIAGFLILANIVISLIFIFQEPLALENRRLFPAPSTIAPYMGIVYFALDATCLIFPLENQMRHPQHYLGCPGIVNLNYICLAILYSFFGAVGYIRYGDAVESSIILNFPTENVLVSCIQVLSAVAVLFSIGLIFYVPTEIAWKKLHTKVPKRWSGLAQSGLRLGMLAVNIAAACGIPHLGTFMGLLGAVLNPILALWIPIVVDTVYRWPNDFGPLRWRLAKNGALGCFGLFLLVTGTVSSVNNIIELYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIM9</accession>
    <name>A0A182PIM9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIM9"/>
    <dbReference type="STRING" id="199890.A0A182PIM9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006791-RA">
        <property type="protein sequence ID" value="AEPI006791-PA"/>
        <property type="gene ID" value="AEPI006791"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006791"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.140.10:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="375"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="765"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006791-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="832" mass="93769" checksum="414159CFD59A3E9E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIU9</accession>
    <name>A0A182PIU9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIU9"/>
    <dbReference type="STRING" id="199890.A0A182PIU9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006862-RA">
        <property type="protein sequence ID" value="AEPI006862-PA"/>
        <property type="gene ID" value="AEPI006862"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006862"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000674">
        <property type="entry name" value="Mucin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006862-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="91" mass="10327" checksum="22338D2E8D8C2830" modified="2016-09-07" version="1">MPETTGPSSVPGEEDEEAEEELLPPEIVCEDPREVYNECGSACDDRTCEDLRRNDLQCTKQCVEGCFCRNGYVRDKRDRCIPAYRCGKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ61</accession>
    <name>A0A182PJ61_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJ61"/>
    <dbReference type="STRING" id="199890.A0A182PJ61"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006975-RA">
        <property type="protein sequence ID" value="AEPI006975-PA"/>
        <property type="gene ID" value="AEPI006975"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006975"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead" evidence="13">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006975-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="732" mass="80899" checksum="29D44689312BBEB1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJC9</accession>
    <name>A0A182PJC9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJC9"/>
    <dbReference type="STRING" id="199890.A0A182PJC9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007043-RA">
        <property type="protein sequence ID" value="AEPI007043-PA"/>
        <property type="gene ID" value="AEPI007043"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007043"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000232">
        <property type="entry name" value="Organic cation/carnitine transporter 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="107"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007043-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="577" mass="62746" checksum="CBF2E0E3F8248234" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJF3</accession>
    <name>A0A182PJF3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trichohyalin-plectin-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJF3"/>
    <dbReference type="STRING" id="199890.A0A182PJF3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007067-RA">
        <property type="protein sequence ID" value="AEPI007067-PA"/>
        <property type="gene ID" value="AEPI007067"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007067"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043596">
        <property type="entry name" value="CFAP53/TCHP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="322"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007067-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="53329" checksum="735064D576316494" modified="2016-09-07" version="1">MLFYPEISIQNELKKLMSCADQEYDHQLEEKRKRLQSLLQSEQEQQEREIMKKFQEEEATRLRERTNALLSAKQDQERQRMEFVKSKMIQLKLNNCDEIRSFIQQKYHEESKKCQLAQIEEKMKLKQAKMDEERMWTEVHVRKYKMDLQNEQQEKHERKIMEQKTLQDIKNQIKEKSLKAAQDKIDLQKVVCASLPFPDHDPKLRALGKAELAEHLSEQIALRKELQRKQTEQDKQLIRTINETSSKELEQERQTRKAEDMLLKKQKDQFYQYSKHVIRQRQLEDGKLEKLINDTREKFEREKLEACRREKQKRLQLASIAYEGQRLQIAEMEARKAREREERQQEALRERELHEKNRKEAEQADCRIQTAVQQYRDSLKEQIKSASLDRERSKRANQMETNRLIERSFNELSFVQSYVKGSFEEHFKKHPNVSLMKRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJG9</accession>
    <name>A0A182PJG9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pickpocket</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJG9"/>
    <dbReference type="STRING" id="199890.A0A182PJG9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007083-RA">
        <property type="protein sequence ID" value="AEPI007083-PA"/>
        <property type="gene ID" value="AEPI007083"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007083"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007083-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="63256" checksum="482BED3D529BD8C6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJM5</accession>
    <name>A0A182PJM5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJM5"/>
    <dbReference type="STRING" id="199890.A0A182PJM5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007139-RA">
        <property type="protein sequence ID" value="AEPI007139-PA"/>
        <property type="gene ID" value="AEPI007139"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007139"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007139-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="63" mass="7221" checksum="DB64155C874A6D77" modified="2016-09-07" version="1">MPFGRKSPLEALAMPGAIIAYKYSQFRQRRREAANRRVTERELSALHTKIPIHSMNAPLTRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLH0</accession>
    <name>A0A182PLH0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A182PLH0"/>
    <dbReference type="STRING" id="199890.A0A182PLH0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007790-RA">
        <property type="protein sequence ID" value="AEPI007790-PA"/>
        <property type="gene ID" value="AEPI007790"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007790"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000005">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000006">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="329"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007790-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="733" mass="81907" checksum="D20DBECD1F06F437" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLI5</accession>
    <name>A0A182PLI5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dephospho-CoA kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLI5"/>
    <dbReference type="STRING" id="199890.A0A182PLI5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007805-RA">
        <property type="protein sequence ID" value="AEPI007805-PA"/>
        <property type="gene ID" value="AEPI007805"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007805"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000485">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000025">
        <property type="entry name" value="Midline fasciclin, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000031">
        <property type="entry name" value="periostin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000023">
        <property type="entry name" value="periostin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EMI" evidence="9">
        <location>
            <begin position="361"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="8">
        <location>
            <begin position="460"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="8">
        <location>
            <begin position="623"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="8">
        <location>
            <begin position="786"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="8">
        <location>
            <begin position="936"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007805-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1104" mass="123828" checksum="E1A08E606AA0A235" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLV3</accession>
    <name>A0A182PLV3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein SCAI</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLV3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007925-RA">
        <property type="protein sequence ID" value="AEPI007925-PA"/>
        <property type="gene ID" value="AEPI007925"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007925"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022709">
        <property type="entry name" value="SCAI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21243">
        <property type="entry name" value="PROTEIN SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12070">
        <property type="entry name" value="SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007925-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56617" checksum="C0DDBAB4BD3E65D7" modified="2016-09-07" version="1">MVKMASTEEQDRKIVLEFCHLLEKSKQLFNGLRDLPQYGHRQWQAYFGRTFDVYTKLWKFQQQHRLVLDSKYEPEDQLEWSLVLEEIKGFIKAESAVAVLHADTNPIVLSHRLSPLTTPPCERTPHMTLSLQEILIVGSACEQAKFSELTMDMFRMLQTLEREPTDAMHPMIGHPMAHGGPHDASPAASRMPYGVPGSKGYVENGDRRTMRDNPHKYLLYKPSLSQLMVFLSSGFKELPPGGALLLYMSADGCFSTTKHPQDYGYELGGLATSVKRDAVDSGLSVRGKSSAGYKEPHCLYPGDLYPYTRRPLFIIIDSDNSFVFQHIPRYFGQPLVILMSPQDIPANYQDLQHHGSLFTLFLHSPMTAMCYICNVGDVPIHHWERCQSYVDRFVTEASRLVTRCRMDEIEQGIGYIDSSYVQFFGDDFLRTLILRFVFCDVALRLHRGFRGRHQRPRCEPPLPGPELLEHPSLAHIVLQLATALDVRGHFVEGPEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM70</accession>
    <name>A0A182PM70_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PM70"/>
    <dbReference type="STRING" id="199890.A0A182PM70"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008043-RA">
        <property type="protein sequence ID" value="AEPI008043-PA"/>
        <property type="gene ID" value="AEPI008043"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008043"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131518" description="GH18 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="26"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008043-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="404" mass="43436" checksum="89D41BAACD22C7B3" modified="2016-09-07" version="1">MERPLLSCLLLMCLVLAYTPEIAAQRSRVCFAQSGDYTDTTALGFCSHAVYIALNPTSRANVGIINPANDADDLLGGIKKFATLKSKYTHVEIYMGVLGSVAAGQLAWLPVLDSRKTFIDLLVTKMQAYPEMTGVYLDFEGLTTTLRNGYALFVSELNTALVAKGLKLVTALPWDASASADIYYSTLLATLPFNVIKMHEEMYPTATTTRPISPLFALASPFDVETRTIYNNVFRWVLKGFLTTNIVISLPNYSVKFTTSGATQFGGAATSIVKDTYCNGLLFGSQNTLGAVRGGEGFAYSASTFYTYNSPAALVDKLQFVIATNLAGVGVYSLDQAGSRNTEMLRQVTSVLAPTPPTATPYPEAEAPTCGVPVEYDNLVSEYCLNLKAVAAYVAKGANCGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PME8</accession>
    <name>A0A182PME8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="STRING" id="199890.A0A182PME8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008121-RA">
        <property type="protein sequence ID" value="AEPI008121-PA"/>
        <property type="gene ID" value="AEPI008121"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008121"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18598">
        <property type="entry name" value="ABC_6TM_MRP7_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18605">
        <property type="entry name" value="ABC_6TM_MRP7_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000113">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001712">
        <property type="entry name" value="ATP-binding cassette protein putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000037">
        <property type="entry name" value="ATP-binding cassette subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF330">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="992"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1065"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1090"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1184"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1209"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="291"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="637"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="972"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1272"/>
            <end position="1505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008121-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1510" mass="168004" checksum="5741A7037805A8D0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMT3</accession>
    <name>A0A182PMT3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sialin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">H(+)/nitrate cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">H(+)/sialic acid cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Vesicular excitatory amino acid transporter</fullName>
        </alternativeName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitrate(out) + H(+)(out) = 2 nitrate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71539"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71540"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>D-glucuronate(out) + H(+)(out) = D-glucuronate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72591"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:72592"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-aspartate(out) = L-aspartate(in)</text>
            <dbReference type="Rhea" id="RHEA:66332"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66333"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-glutamate(out) = L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:66336"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:66337"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-acetyl-L-aspartyl-L-glutamate(out) = N-acetyl-L-aspartyl-L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:72599"/>
            <dbReference type="ChEBI" id="CHEBI:76931"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:72600"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-acetylneuraminate(in) + H(+)(in) = N-acetylneuraminate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28987"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35418"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:28989"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMT3"/>
    <dbReference type="STRING" id="199890.A0A182PMT3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008257-RA">
        <property type="protein sequence ID" value="AEPI008257-PA"/>
        <property type="gene ID" value="AEPI008257"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008257"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000067">
        <property type="entry name" value="sialin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF455">
        <property type="entry name" value="GH23975P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="27">
        <location>
            <begin position="27"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00056891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00069713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00080244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00081195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00081925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008257-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="487" mass="53802" checksum="828FD07E22B6F839" modified="2016-09-07" version="1">MDATESSKLSDGINAPMWMFWRRRRYVLVFLAFFGFFNVYSLRVNLSVAIVAMTENRTVQYPNGTVGYEQEFNWDSTTKGYILSSFFYGYIFTQLIGGYISNALGGNYVFGVGVGVTAALTLLTPLAAHAGFGWLIAVRAVEGFFEGVTFPCIHAIWSNWAPPSERSRMATIAFSGVFTGTVASMLLSGVLADTLGWEWVFYILGAFGCLWFVAWMLIVKKSPETDPYISTKEKEFILATLQRSAGASAKVQHPWCGILTSPAVWALIVSSFSENWGFYTLLTQLPKFLRDTMHFELQAAGFLSALPYLVMGLLLSVAGYLADLCQIRRWLTTTQVRRYFNCGAFLAQTVFMLVGAYVLRPGPTLACITIAVGCGAFAWCGFAVNHLDLSPKSAGVLMGISNTFSTVAGILTPIVSGQITAGGRENEWRTVFYIAAGIYLVGCVTYWFGASGELQPWSIELREREQKRSEQEGNGYVNEGLVMEQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNG4</accession>
    <name>A0A182PNG4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNG4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008491-RA">
        <property type="protein sequence ID" value="AEPI008491-PA"/>
        <property type="gene ID" value="AEPI008491"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008491"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008491-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="458" mass="52444" checksum="8C2A4B2AA0AA6508" modified="2016-09-07" version="1">MEWARKWCLVNGFLVASALRVVFGLQTIIFVERTLTNADRRGTSCWTRFSNFATAHDGGVRELFMMIVVLLSSCVGFGCTYWHWSDETSLTNGIIAPNDCPSQNCAKSKQAFNMEVIIAFALPLLVTVSIYLYRWNSRAMIGSLNRSFRFIYNHQKFHHSQRQCCAWDQYGRLVMKQVFEVMALGVLWLNLRPLSRTKYGDDVEDYRVGKLIASMGSMLPAVVCLLVSIEMGINFSFIARTLTTLNWFLDSLVRHNDTNSFTKPTQVKHIRYLNVIPNKGEISTRNSLRKFIAEYDELGHFTVEMVAFYSPSLLLILGMHFVLFTMQVSDVAIYFSMPFTTSKTLPHFTLLLSKVVIFLIFYNSPLIYSSSCATDKCHEQRIDDMVEILCHLSLAYENSALHNGNMKEIDKTLTILSLIVNKIRNSINLYDYFDLDRSLVMTIIASTCSYLIVLIQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNL1</accession>
    <name>A0A182PNL1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CAAX prenyl protease 2</fullName>
            <ecNumber evidence="11">3.4.26.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Farnesylated proteins-converting enzyme 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182PNL1"/>
    <dbReference type="STRING" id="199890.A0A182PNL1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008538-RA">
        <property type="protein sequence ID" value="AEPI008538-PA"/>
        <property type="gene ID" value="AEPI008538"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008538"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="14">
        <location>
            <begin position="77"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008538-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="234" mass="27247" checksum="31738AC322F38893" modified="2016-09-07" version="1">MLVAPFFVLTLTSKDVLQHYTMWQIMGFRQEGLFTAIFVPLLLTMVLFLGPLSVQLSNGIWRIYSEPMYWMNAVRNLVWLRNHLVAPLSEEFTFRACMLPLLLQTYRPSVAMLITPLLFGLAHLHHIKERLQKGRPLKEVLILSFFQFFYTTIFGIYSAHLFVRSGHFVAPFIVHAFCNHMGFPDLQEVLSQSHRKKYLFIGFYVLGLVGWIVLLPTLTTPSWYTNNLFWAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNV0</accession>
    <name>A0A182PNV0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nardilysin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNV0"/>
    <dbReference type="STRING" id="199890.A0A182PNV0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008629-RA">
        <property type="protein sequence ID" value="AEPI008629-PA"/>
        <property type="gene ID" value="AEPI008629"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008629"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="10">
        <location>
            <begin position="133"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="11">
        <location>
            <begin position="295"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="12">
        <location>
            <begin position="485"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="12">
        <location>
            <begin position="609"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="11">
        <location>
            <begin position="715"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008629-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1035" mass="118807" checksum="4207D0B9B208BA59" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPF0</accession>
    <name>A0A182PPF0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPF0"/>
    <dbReference type="STRING" id="199890.A0A182PPF0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008829-RA">
        <property type="protein sequence ID" value="AEPI008829-PA"/>
        <property type="gene ID" value="AEPI008829"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008829"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056200">
        <property type="entry name" value="NT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF147">
        <property type="entry name" value="EG:BACR7A4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24103">
        <property type="entry name" value="NT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131688" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="236"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008829-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="663" mass="73899" checksum="A9021CBEC90C2608" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPN3</accession>
    <name>A0A182PPN3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPN3"/>
    <dbReference type="STRING" id="199890.A0A182PPN3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008912-RA">
        <property type="protein sequence ID" value="AEPI008912-PA"/>
        <property type="gene ID" value="AEPI008912"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008912"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF106">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131580" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008912-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="224" mass="24445" checksum="36270EDD94810151" modified="2016-09-07" version="1">MYGGIIVVMASLLLRDSLAQRTVPASCYNASTAPDYLCPPDVARLRLEHETSCTRYYVCENGKATEMSCPGRRFFNPRTQRCGRSARPCQTNAQALIRHVAECRPSGEQLCQRPFVPYPSAANATSVLVCNVDGSAFLAHCPRTPTGLQTAFVNGKCRVRQAMRGQHKWAKLLQCPGRYPPDLPVSINRTDRTRAGIRPLDTAGGSPGMSCGKQAMLNIETVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPS1</accession>
    <name>A0A182PPS1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPS1"/>
    <dbReference type="STRING" id="199890.A0A182PPS1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008951-RA">
        <property type="protein sequence ID" value="AEPI008951-PA"/>
        <property type="gene ID" value="AEPI008951"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008951"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0222">Digestion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131627" description="Peptidase S1 domain-containing protein" evidence="11">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="32"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008951-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="269" mass="27538" checksum="3F2461B0EE7E980C" modified="2016-09-07" version="1">MKSVVALLCLVAVAAAAPRSIQAKYGFPSGRVVGGVDALPGEFPSIVSIQRVILVVSAHVCGGSVLSNFWILTAAHCITESPATANFQIWAGSHNTAIDEPTRQVISVASSTVHPDYLGGVNPTDIAVMRLAAPLTFTPRVQPIVLPAPGSNPTGPVTLAGWGSTGGTIPTLPNILQKVTKPLITYAECEAAAGADSPLGPTNICTGPLTGGVSACSGDSGGPLYSIQGGQQVQVGIVSWGWIPCGTVGFPSVYVGVSHYIDWIQNNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPW2</accession>
    <name>A0A182PPW2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DDB1- and CUL4-associated factor 6-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPW2"/>
    <dbReference type="STRING" id="199890.A0A182PPW2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008992-RA">
        <property type="protein sequence ID" value="AEPI008992-PA"/>
        <property type="gene ID" value="AEPI008992"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008992"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF39">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="677"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008992-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="79389" checksum="72F9C486CEBA49B0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ09</accession>
    <name>A0A182PQ09_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQ09"/>
    <dbReference type="STRING" id="199890.A0A182PQ09"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009039-RA">
        <property type="protein sequence ID" value="AEPI009039-PA"/>
        <property type="gene ID" value="AEPI009039"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009039"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="3">
        <location>
            <begin position="18"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009039-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="181" mass="20741" checksum="885ED16FED22461E" modified="2016-09-07" version="1">MDVKDETQFEYTISNFTACCRICLSTKENEPYYDIYLTSLASYQEITLIEAIQRITNVEVLTNSKLPSKICKLCSARLDDAYCLARDFIRINEMLHNYLDNEVMDRDDGGDINLTTIEELCGLDVPEEEVKGEEQQLEGMIESELPPQQVDDQSEDSKQQQQQPDNQSDCAELQHQQPSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQN1</accession>
    <name>A0A182PQN1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(+) ADP-ribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.30</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
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            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="65"/>
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        </location>
    </feature>
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        <location>
            <begin position="426"/>
            <end position="491"/>
        </location>
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        </location>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="503" mass="54897" checksum="2B4B92263A962A46" modified="2016-09-07" version="1">MSSDRIHRAAKDGLLDVLREATRSEANAKDVDGMTPVLWAAFEGHFDALKLLVARGGDPDKADQFGNTALHLAAAKGHMQCVDFLVQFGVNLYALDIDHHSAQDLAAINNRDKILRYLDAAAATLEATDRKKAHEYREQAKKKSEKRAREFASRQQKIDREQDTSIRIRPHRPSNMLTALKHKLWSGSQGNLAQGQPKIVNESLSQLPPPASATKFSALVGGTVLRGGGAVKKRADAMKIRQQMENGDFKIGEMEANGKRSVRSIQGLRRDSEVLYVGTYSSNDESNASDRRGKLKDVFDVDPSNANGRENDEADEDSGSGASGKFGTMSRSLSQPDFLAGAGNDDGVTEDVLLQRPSGLFSRPSFGNLAFPRSVSNVLAQLGSEQTSSASSDGSIKVKPTTKGAIKPRSQLVISDSDSELESSGNEENDSLAILRFLSAFKLEDYYPVFQKNEIDMETLMMLTENDVKSLGLPLGPYRRLCNAIQERKEALAAPGTINDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQU0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PQU0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009321-RA">
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        <property type="gene ID" value="AEPI009321"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009321"/>
    <dbReference type="Proteomes" id="UP000075885">
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="349"/>
        </location>
    </feature>
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        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1290" mass="142328" checksum="3664788C5D98A769" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQU8</accession>
    <name>A0A182PQU8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQU8"/>
    <dbReference type="STRING" id="199890.A0A182PQU8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009329-RA">
        <property type="protein sequence ID" value="AEPI009329-PA"/>
        <property type="gene ID" value="AEPI009329"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009329"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF4">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="105"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009329-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="393" mass="45111" checksum="20FF3B34EFD821EC" modified="2016-09-07" version="1">MATITMAASPTSNSSASTTSVSLLQRQSSKNADTVSVCSTTSAFSTCPDRHGFYGGNQFSEKPKKETLTREQIIAREKKWIHMTSHWAEYMNTNYKKVRERCRKGIPDALRQKAWFLLTGANHLMGKFPDWYQHLLDQPGNPQIIDEIRKDQHRQFPHHEMFIDDDKPGQKELFNVLKAYSVYNPTVGYCQAQAPIAAFLLMQLPSEQAFWCFVAICDKYLENYFTPGLEMLQRDAGMLNRLLKKTSPAAYRHLQKHNVDPLLYMTDWFLCAMTRTLPWDTLLRVWDCFLCEGVRIFFKVALVIIGATLGPQKVRSQCNGLCETLAVLRSPPKKFLEEDFIMHHIFRLNITIEDFHREHKKQEMLHRKAKLEQQKAAQQNGGGGSSNGPSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQV5</accession>
    <name>A0A182PQV5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="25">PARP</shortName>
            <ecNumber evidence="25">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="29 30">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="25"/>
    <dbReference type="STRING" id="199890.A0A182PQV5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009336-RA">
        <property type="protein sequence ID" value="AEPI009336-PA"/>
        <property type="gene ID" value="AEPI009336"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009336"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09524">
        <property type="entry name" value="SAM_tankyrase1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01438">
        <property type="entry name" value="tankyrase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AGAP001945-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000009">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000010">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase tankyrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="19 24" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 25" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 25" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="26" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0779">Telomere</keyword>
    <keyword evidence="8 25" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131703" description="Poly [ADP-ribose] polymerase" evidence="26">
        <location>
            <begin position="21"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="317"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="480"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="513"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="546"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="633"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="666"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="27">
        <location>
            <begin position="853"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="28">
        <location>
            <begin position="929"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009336-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1769" mass="191060" checksum="4F15745BD450B4D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRV2</accession>
    <name>A0A182PRV2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cleavage and polyadenylation specificity factor subunit 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRV2"/>
    <dbReference type="STRING" id="199890.A0A182PRV2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009687-RA">
        <property type="protein sequence ID" value="AEPI009687-PA"/>
        <property type="gene ID" value="AEPI009687"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009687"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="13">
        <location>
            <begin position="254"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="14">
        <location>
            <begin position="485"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009687-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="78022" checksum="2E0AA78A6DF83DED" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS02</accession>
    <name>A0A182PS02_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Charged multivesicular body protein 1b</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PS02"/>
    <dbReference type="STRING" id="199890.A0A182PS02"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009737-RA">
        <property type="protein sequence ID" value="AEPI009737-PA"/>
        <property type="gene ID" value="AEPI009737"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009737"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009737-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22204" checksum="D36EC417B73F483E" modified="2023-06-28" version="2">MSAMEKHLFNLKFAVKELERNAKKCEKEEKAEILKTKKAIQKGNTEVARIHAENAIRQKSQSLNYLRMSARVDAVASRVQTALTTRNVTNSMAGVVKAMDAAMKGMNLEKISGLMDKFESQFEDLDVQSSYMENTMSQTTTTAVPQNDVESLMQRVADEAGLELNMELPSGPSSVAIGASTQASTEQDELTARLARLRQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSX3</accession>
    <name>A0A182PSX3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSX3"/>
    <dbReference type="STRING" id="199890.A0A182PSX3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010059-RA">
        <property type="protein sequence ID" value="AEPI010059-PA"/>
        <property type="gene ID" value="AEPI010059"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010059"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01737">
        <property type="entry name" value="LSm16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000009">
        <property type="entry name" value="AGAP003131-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034107">
        <property type="entry name" value="Lsm16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="344"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010059-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="562" mass="61047" checksum="AB23025D356E9DF1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTG9</accession>
    <name>A0A182PTG9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PTG9"/>
    <dbReference type="STRING" id="199890.A0A182PTG9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010255-RA">
        <property type="protein sequence ID" value="AEPI010255-PA"/>
        <property type="gene ID" value="AEPI010255"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010255"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010255-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="116" mass="13671" checksum="C8C3051D06A2E3EC" modified="2016-09-07" version="1">MFNTCTQKQKKKKKWKQGFSAGSANPVASFHTPSFGDEEFDMQSMNSHLQQQQPQQQQTQQHHQQHPQQQQQQQQQYQMHSGTQQQSGHMVGMLQDQQQSSYGQWHQDMNHHKPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTT1</accession>
    <name>A0A182PTT1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182PTT1"/>
    <dbReference type="STRING" id="199890.A0A182PTT1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010367-RA">
        <property type="protein sequence ID" value="AEPI010367-PA"/>
        <property type="gene ID" value="AEPI010367"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010367"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="13">
        <location>
            <begin position="166"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010367-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="534" mass="59698" checksum="300FE272F02ACCBD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTT7</accession>
    <name>A0A182PTT7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PTT7"/>
    <dbReference type="STRING" id="199890.A0A182PTT7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010373-RA">
        <property type="protein sequence ID" value="AEPI010373-PA"/>
        <property type="gene ID" value="AEPI010373"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010373"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF8">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010373-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="78699" checksum="591B339237538259" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTV8</accession>
    <name>A0A182PTV8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTV8"/>
    <dbReference type="STRING" id="199890.A0A182PTV8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010394-RA">
        <property type="protein sequence ID" value="AEPI010394-PA"/>
        <property type="gene ID" value="AEPI010394"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010394"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000062">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="13">
        <location>
            <begin position="45"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="336"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="431"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010394-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="878" mass="98530" checksum="178D58C387720239" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU57</accession>
    <name>A0A182PU57_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Frizzled/Smoothened 7TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PU57"/>
    <dbReference type="STRING" id="199890.A0A182PU57"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010493-RA">
        <property type="protein sequence ID" value="AEPI010493-PA"/>
        <property type="gene ID" value="AEPI010493"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010493"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Frizzled/Smoothened 7TM" evidence="3">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010493-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="69" mass="7806" checksum="C679385F2F42A4C4" modified="2016-09-07" version="1">MFVLTFLIDSSRFRYPERPIVFLAICYLIVGCAYVAGLGAGDSVACREPFQSHIKIGRMQMLSTITQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU62</accession>
    <name>A0A182PU62_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Vesicular inhibitory amino acid transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 32 member 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Vesicular GABA transporter</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4-aminobutanoate(out) + n H(+)(in) = 4-aminobutanoate(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70979"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>beta-alanine(out) + n H(+)(in) = beta-alanine(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70987"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70983"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU62"/>
    <dbReference type="STRING" id="199890.A0A182PU62"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010498-RA">
        <property type="protein sequence ID" value="AEPI010498-PA"/>
        <property type="gene ID" value="AEPI010498"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010498"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060077">
        <property type="term" value="C:inhibitory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140800">
        <property type="term" value="F:gamma-aminobutyric acid:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051939">
        <property type="term" value="P:gamma-aminobutyric acid import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000062">
        <property type="entry name" value="Vesicular inhibitory amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF689">
        <property type="entry name" value="VESICULAR INHIBITORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="21">
        <location>
            <begin position="162"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="31"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010498-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="569" mass="62939" checksum="1F18F6C5470292F2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV48</accession>
    <name>A0A182PV48_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PV48"/>
    <dbReference type="STRING" id="199890.A0A182PV48"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010835-RA">
        <property type="protein sequence ID" value="AEPI010835-PA"/>
        <property type="gene ID" value="AEPI010835"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010835"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053011">
        <property type="entry name" value="SDR_family_member_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010835-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="581" mass="66484" checksum="E129E85EF6522B6E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVS7</accession>
    <name>A0A182PVS7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Trehalase</fullName>
            <ecNumber evidence="3 7">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3 7"/>
    <dbReference type="AlphaFoldDB" id="A0A182PVS7"/>
    <dbReference type="STRING" id="199890.A0A182PVS7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011064-RA">
        <property type="protein sequence ID" value="AEPI011064-PA"/>
        <property type="gene ID" value="AEPI011064"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011064"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011064-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="630" mass="72024" checksum="72507CF1244A4F22" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWC3</accession>
    <name>A0A182PWC3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWC3"/>
    <dbReference type="STRING" id="199890.A0A182PWC3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011260-RA">
        <property type="protein sequence ID" value="AEPI011260-PA"/>
        <property type="gene ID" value="AEPI011260"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011260"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF216">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="41"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="898"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="1176"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011260-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1246" mass="138303" checksum="9695244B9E0643FC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWK2</accession>
    <name>A0A182PWK2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Regulator of telomere elongation helicase 1 homolog</fullName>
            <ecNumber evidence="17">5.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">A probable ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.-" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A182PWK2"/>
    <dbReference type="STRING" id="199890.A0A182PWK2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011339-RA">
        <property type="protein sequence ID" value="AEPI011339-PA"/>
        <property type="gene ID" value="AEPI011339"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011339"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090657">
        <property type="term" value="P:telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17970">
        <property type="entry name" value="DEAHc_FancJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13932">
        <property type="entry name" value="HN_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Regulator of telomere elongation helicase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Regulator of telomere elongation helicase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
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        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
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    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030845">
        <property type="entry name" value="RTEL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057498">
        <property type="entry name" value="Rtel1_ARCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049909">
        <property type="entry name" value="Rtel1_HHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23109">
        <property type="entry name" value="ARCH_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23116">
        <property type="entry name" value="HHD_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 17" id="KW-0408">Iron</keyword>
    <keyword evidence="10 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="7"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011339-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="991" mass="111576" checksum="832F63A41CCA4CAF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWM5</accession>
    <name>A0A182PWM5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWM5"/>
    <dbReference type="STRING" id="199890.A0A182PWM5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011362-RA">
        <property type="protein sequence ID" value="AEPI011362-PA"/>
        <property type="gene ID" value="AEPI011362"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011362"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="112"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011362-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="317" mass="36462" checksum="B9B87B3D0CE74D22" modified="2016-09-07" version="1">MFSNIFETIHRFLRLKVEDFEFLLSLVGPKIAKMDTNMREAITPKERLLNHCVSRHSITKIVKETCACIKEVLHSYVKVMNPMKLPSTQEEWLAVSKRFEERWKFPHAIGAIDGKHVHIVAPRDSGSEYFNYKNFFSIVLMVVVDADYNFMYADAGGKGGISDGGIFKNTRLYQRLENKRMNIPPPEPLQIPYQTEVPYFMLGDKAFAFTEYCIRPYGGNHGPDTAERIFNKKHSTARMPVENSLGILCNRFRVLKGPIHLQPDYAKEVIITTVYLHNFLRSLPTLLNLHSTGFKTEQLCKEIGEAKAPSQVYNLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWT3</accession>
    <name>A0A182PWT3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWT3"/>
    <dbReference type="STRING" id="199890.A0A182PWT3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011420-RA">
        <property type="protein sequence ID" value="AEPI011420-PA"/>
        <property type="gene ID" value="AEPI011420"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011420"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011420-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="209" mass="23666" checksum="A48C7AF3E85C9850" modified="2016-09-07" version="1">MDALRTFVRSADLDIIFLQEVYDAEFTIPGYNVLTNVNDEPLLLYARSLNSRLISLRLKNATTLCNIYAPSGSHRRTEREIFFNQTLPFYLQNARESVILAGDFNSVLNSKDATSGADISHALLCVVNSLGLCDSWEHLKGNAVEFSFIARTSGSRIDRCYVSKSLKDKLKTTYMHIIKHLQSVSPFQSVRLREETETGNSVRTFCRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWY1</accession>
    <name>A0A182PWY1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Galactokinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWY1"/>
    <dbReference type="STRING" id="199890.A0A182PWY1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011468-RA">
        <property type="protein sequence ID" value="AEPI011468-PA"/>
        <property type="gene ID" value="AEPI011468"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011468"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="6">
        <location>
            <begin position="129"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="7">
        <location>
            <begin position="365"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011468-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="52734" checksum="E4B5361F1141EB28" modified="2016-09-07" version="1">MASDRGALCVEVLEAVPECKRLSRLLECFSNEFARRPSFVVRCSGRVNIIGEHVDYCGYPVFPMAIEQTILLAVAPSDDNLLHIKNADNNFKPYKCNVLNYLIDVPTVGGPHWYQYVLCGVKGILENSTIQHDSPRGMMILLSGNIPPASGLSSSSAIVSATVLATAYMHNATLNKQTLATISAECEKFIGTQGGGMDQAIAYLAQEGCAQLIEWNPLRATPIQLPENAVFVIANSLSEANKAATSDFNQRVVECRLASRLLAKQMKLNWRDLNRFADLQKALGYSLEQMVSLVHANLGLNVYTRTELITLLEVTEEDFADNLLTPNTRNSQTFKLRQRALHVFQEALRVQQFIETAKSTSEDCISRMKTLMKQSHESLRTINECPHDNLDRIVAISDRLGVGTRLTGAGWGGCVVALCDGVEESKRFVETLKTEFYTSIPKAQGCDIGSVCFTTSPQRGAEIYLIDKHQNIWTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWY7</accession>
    <name>A0A182PWY7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWY7"/>
    <dbReference type="STRING" id="199890.A0A182PWY7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011474-RA">
        <property type="protein sequence ID" value="AEPI011474-PA"/>
        <property type="gene ID" value="AEPI011474"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011474"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011474-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="60594" checksum="85351E902AA07B8B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX74</accession>
    <name>A0A182PX74_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX74"/>
    <dbReference type="STRING" id="199890.A0A182PX74"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011561-RA">
        <property type="protein sequence ID" value="AEPI011561-PA"/>
        <property type="gene ID" value="AEPI011561"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011561"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011561-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="708" mass="79763" checksum="0490E651085D0683" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PL15</accession>
    <name>A0A240PL15_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ninjurin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PL15"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015351-RA">
        <property type="protein sequence ID" value="AEPI015351-PA"/>
        <property type="gene ID" value="AEPI015351"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015351"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007007">
        <property type="entry name" value="Ninjurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12316:SF20">
        <property type="entry name" value="NINJURIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12316">
        <property type="entry name" value="NINJURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04923">
        <property type="entry name" value="Ninjurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015351-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="152" mass="16683" checksum="D0162BA3814EA438" modified="2017-10-25" version="1">MPCFSEATDQPTNKQLNAELSSFVQKKSFAQNMMDIALLSANTNQLRYVIDLGEKHPYYMTSLMLIIVSLVMQIVVGLSMLYVNRYNMKNRSEIKAASHMNNLSVAGVFLVTLVNVFISTFNGAGAGTIPPPDTSGILPQNVSNSSVPYDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PNB5</accession>
    <name>A0A240PNB5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PNB5"/>
    <dbReference type="STRING" id="199890.A0A240PNB5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015288-RA">
        <property type="protein sequence ID" value="AEPI015288-PA"/>
        <property type="gene ID" value="AEPI015288"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015288"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010948">
        <property type="term" value="P:negative regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901990">
        <property type="term" value="P:regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="142"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="619"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015288-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="679" mass="74902" checksum="B46C7ED5E9A3D5D2" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FGY8</accession>
    <name>A0A9I3FGY8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 8"/>
    <dbReference type="AlphaFoldDB" id="A0A9I3FGY8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015542-RA">
        <property type="protein sequence ID" value="AEPI015542-PA"/>
        <property type="gene ID" value="AEPI015542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000114">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="331"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015542-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="501" mass="55520" checksum="C6CADC6E713FAD27" modified="2023-06-28" version="1">MVISKICCIGAGYVGGPTCSVMALKCPDIQITVVDRSTERIAQWNSDKLPIYEPGLDDVVRQCRNRNLFFSTDIEKAIQEAELIFISVNTPTKTYGNGRGRAADLKYVEGCARMIAEMSQNSKIVVEKSTVPVRAAESIMHILKANHKPGVKYDILSNPEFLAEGTAVEDLLKPDRVLIGGEQTPEGQAAIEKLCWVYEHWIPKKNIITTNTWSSELSKLAANAFLAQRISSINSLSAVCEATGADVSEVARAVGLDSRIGPKFLQASVGFGGSCFQKDILNLVYICEGLNLPEVAAYWQQVIDMNDYQKTRFSQKIIECLFNTVTDKRISILGFAFKKNTGDTRETPAITVCRTLLDEGAQLNIYDPKVEPEQIIADLTHPKVTESPEHVKRAVQIFADPYDAVRGTHALVVCTEWDEFVSLNYERIYASMMKPAYIFDGRKILPHERLQEIGFHVQTIGKRLLQQQYHDPTVRPIPSHLTNGHGHGPLPANGDGPSAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZF5</accession>
    <name>A0A182NZF5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 snRNA phosphodiesterase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3'-5' RNA exonuclease USB1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end uridylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine</text>
            <dbReference type="Rhea" id="RHEA:46052"/>
            <dbReference type="Rhea" id="RHEA-COMP:17384"/>
            <dbReference type="Rhea" id="RHEA-COMP:17385"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:85643"/>
            <dbReference type="ChEBI" id="CHEBI:85644"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:46053"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZF5"/>
    <dbReference type="STRING" id="199890.A0A182NZF5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000035-RA">
        <property type="protein sequence ID" value="AEPI000035-PA"/>
        <property type="gene ID" value="AEPI000035"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000035"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000035-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="170" mass="20061" checksum="18D5DE8466BF36BD" modified="2016-09-07" version="1">MQNECKALLSSTTSFEFNPIDRMHLSLTKTFTIRHHNIAPFVENLREQLDGRRRFRLEFSGVQVYVNEERTRTFIGVRVAEESYGPLNELVSSLDECLCEYKLPLYYTDRSFHVSILWCLGDREAEVRSELPAIIAVFERVYEEEYCDISQQVKTLWFKCGNKSFHFDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0F6</accession>
    <name>A0A182P0F6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0F6"/>
    <dbReference type="STRING" id="199890.A0A182P0F6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000388-RA">
        <property type="protein sequence ID" value="AEPI000388-PA"/>
        <property type="gene ID" value="AEPI000388"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000388"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016360">
        <property type="term" value="P:sensory organ precursor cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19715">
        <property type="entry name" value="bHLH_TS_amos_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000025">
        <property type="entry name" value="protein atonal homolog 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF162">
        <property type="entry name" value="TRANSCRIPTION FACTOR ATOH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000388-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="350" mass="38572" checksum="F196212E2508B95A" modified="2016-09-07" version="1">MSDPPFQCFEPSPRIREAWHDPAGFRPCTDDRVNNIPTQFACVHRSVQIKSFRKVEVLASVVCWLFGKNMEHYTMMGIDRLTTYGHTADTSAVGGATYLSHYPTPDTSLCRSSYSASSPGTSPTVSGPDLSHTNFGLSFADVMFDGETFVQIDSNDLHNYGTGATQLTAGTITPSPLPPSYTPEVPNCGLEVKSCSSTPVSCNTTNHRRLYKSRKAISAGKKDCTPPSPTVLKKRRLAANARERKRMNSLNVAFDRLREIVPSLGPDHKLSKFETLQMAQTYINALSDLLERGADATTYSLFDTMESRVSNDSNNNSSSGNGQLNDSSRQLLLRDDDRSLDDRFLDIGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0Q3</accession>
    <name>A0A182P0Q3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0Q3"/>
    <dbReference type="STRING" id="199890.A0A182P0Q3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000485-RA">
        <property type="protein sequence ID" value="AEPI000485-PA"/>
        <property type="gene ID" value="AEPI000485"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000485"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000485-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="190" mass="21485" checksum="124DBB4DC8E105C1" modified="2016-09-07" version="1">MNQFQLMRFSSRRQSTTRNTSKMNQFYVKVGTDYYCTLCSAEDPVKTDSLKSIAQHLADEHSQEAYVCDLCDIIYFQQSSYVEHLAEHSATSDQDTQPEDTLSCTICSETFESKHALEQHRKIHPNGGAAKSWSCEICDKRANRTLEFETDTFVNDGTGESSEPSQEMEGSDEDMVQVAYICEEGNVEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P151</accession>
    <name>A0A182P151_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P151"/>
    <dbReference type="STRING" id="199890.A0A182P151"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000633-RA">
        <property type="protein sequence ID" value="AEPI000633-PA"/>
        <property type="gene ID" value="AEPI000633"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000633"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001111">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001197">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001523">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="101"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="197"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000633-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="298" mass="33400" checksum="A0DAA6FFB4720984" modified="2016-09-07" version="1">MESAPRNIEVKPLSSSTMLITWEPPETPNGQVTGYKVYYTTNPNQPEASWDSQMETNDMTTISELTPHAIYTIRVQAFTSMGAGPLSNPVQVKAQQGVPSQPSNFRATDVGETAVTLQWSRPTHSGENIVHYELYWNDTYANEQHHQRIPNTETYTLSSLYPDTLYYFWLSARSQRGEGATTPPIPVRTKQYVPGAPPRNVTVEATSPTTINVSWLPPPVERSNGAIVYYKVFFVEVGRSDSEATVTTLNSTSIVLDELKRWTEYKIWVLAGTSVGDGPRSYPYTVRTHEDGMYCTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1A1</accession>
    <name>A0A182P1A1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1A1"/>
    <dbReference type="STRING" id="199890.A0A182P1A1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000683-RA">
        <property type="protein sequence ID" value="AEPI000683-PA"/>
        <property type="gene ID" value="AEPI000683"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000683"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09388">
        <property type="entry name" value="LIM1_LMO1_LMO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09390">
        <property type="entry name" value="LIM2_dLMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000015">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000016">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF1">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="128"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000683-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="230" mass="25960" checksum="0410A8C443E1DB4A" modified="2016-09-07" version="1">MDENYVESINDHTINVQANRNHNSCSVSATTMGHTTVTPSAPATPIQSSVSSTPNLVATTGLAKDCAGCGKRITERFLLKALDIFWHEDCLKCGCCDCRLGEVGSTLYTKANLILCKRDYLRLFGTTGYCAACNKVIPAFEMVMRAKNNVYHLECFACQQCNHRFCVGDRFYLCDNKILCEYDYEERLVFASMACNPSSLAHIRRQKRLERSNNSIINQYPNNNPRQQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1M3</accession>
    <name>A0A182P1M3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1M3"/>
    <dbReference type="STRING" id="199890.A0A182P1M3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000805-RA">
        <property type="protein sequence ID" value="AEPI000805-PA"/>
        <property type="gene ID" value="AEPI000805"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000805"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015291">
        <property type="term" value="F:secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17380">
        <property type="entry name" value="MFS_SLC17A9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000059">
        <property type="entry name" value="Solute carrier family 17 member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000325">
        <property type="entry name" value="Transporter, major facilitator family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044777">
        <property type="entry name" value="SLC17A9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF279">
        <property type="entry name" value="VOLTAGE-GATED PURINE NUCLEOTIDE UNIPORTER SLC17A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="29"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000805-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="437" mass="48779" checksum="524A416D68A7042C" modified="2016-09-07" version="1">MMEEKLKYSFLRDLNDGQSIWTRNEKRTWFLTLLTGTCMLYSTRTTMPLLVPAVAAERKWSKTDSGTVLSSFFWGYTLTQVLGGYLSDKFGGQKVILLAAIGWSLITFWMPNIITSSTLFASYSIPFIVTVRIINGACQGVHFPSMISITSQNLSSCERASFFSILTSGSALGTLLTGIVGSFLLDYFGWPTAFRVIGFLGLSWTLFLRYYTMASDRSRIINISLPSRMYTKLGTPETVPWLRLFERSSFWACVLAHACEMNCFFVLLSWLPTYFHENFPQAKGWVVNMIPWLALPPVTFMGKLLTEHLLAKQWTLTRIRKLVQSLCFLGQNCALFVMCRTQEFNMALTCMSIIIGLSGLHNNAVTVNPQDLAPSHSGSVFGLMNTVGAIPGFLGVYLAGHILELTQSWSAVFSTAAAINTFGWLIFTVFGSAETIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2B0</accession>
    <name>A0A182P2B0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L38</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2B0"/>
    <dbReference type="STRING" id="199890.A0A182P2B0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001044-RA">
        <property type="protein sequence ID" value="AEPI001044-PA"/>
        <property type="gene ID" value="AEPI001044"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001044"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001044-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="70" mass="8290" checksum="86FFAF8FBDC5DB7B" modified="2016-09-07" version="1">MPQEIKEVKDFLIKARRKDARAVKIKKNENNTKFKIRCSRYLYTLVVKDMEKAEKLKQSLPPGLQVKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2P5</accession>
    <name>A0A182P2P5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beclin-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2P5"/>
    <dbReference type="STRING" id="199890.A0A182P2P5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001179-RA">
        <property type="protein sequence ID" value="AEPI001179-PA"/>
        <property type="gene ID" value="AEPI001179"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001179"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000001">
        <property type="entry name" value="beclin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="109"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="239"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="152"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001179-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="49137" checksum="6D3EFBDA753B387E" modified="2016-09-07" version="1">MNDAKVSVSFSCQRCLQPIHVDDTFASLGEHTLAELALPINSHLDVDLESQTASFDHFVPPFRVTESTNDTNGFMLLSDGPDKESLGHTLRVKAELFDALSNNSEIDHPLCDECTDTMLELMDKQLKIAEDEWNDYNNYLKKLEMTDDVPDIEALEHELAELKLDETRLLEELNSLSREEQSIRQAVEEQEKEKQRLEREENKYWREYTKHRRDVITTEDEFRSLECQMAYAQSQLEKLKKTNVFNATFHIWHSGHFGTINNFRLGRLPSAPVDWSEINAAWGQTCLLLSALARKMNYSFKQYRLVPYGNHSYIEVLGEGKELPLYGNGGFRFLWDSKYDAAMVAFLDCLQQFKEEIVRRDPDFCLPYLMEKGKIEDASTGSSFSIKIQFNSEEQWTKALKYLLTNLKWVLTWVSSQFTEDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5E6</accession>
    <name>A0A182P5E6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5E6"/>
    <dbReference type="STRING" id="199890.A0A182P5E6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002136-RA">
        <property type="protein sequence ID" value="AEPI002136-PA"/>
        <property type="gene ID" value="AEPI002136"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002136"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002136-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="403" mass="46481" checksum="AD2ECB052D711929" modified="2016-09-07" version="1">MSKFLSLRRPTTISKLASLVPQHPDALPQEIIPQWADLQPSAKLPDRCCPVHAKDFSRGEVGQALWEFPPQHGFDLQDPCNRVVRRTYEVLHDKHLCEFWTESLWKVKQAQVPDINLKRRDLINREDGRVTCTLMELNEYRNFLFQHYRLQLQRLLNRLANEKSVDDHNTKVQIHMENVPDFAEKLTIRRQRAAGIFGKKMEHQGSLLKLPSFQVRSEIDPSRVSIGPVEIVEHYETESFSLKQCRNRPPTPVTSVTSLVECTMRQSHEERASVSALEVSTETALDILRRIRSDSYPLIHVMYSQRRYLEGNLLKYGMIVQPYVIQRVLAAIDLERLSIVSDFDGGEDSSSPVDERESILLRTANALLRFPESNHQYAIALCDSVHFLSVQAIRKIQQILNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5P4</accession>
    <name>A0A182P5P4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5P4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002235-RA">
        <property type="protein sequence ID" value="AEPI002235-PA"/>
        <property type="gene ID" value="AEPI002235"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002235"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="4">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="3">
        <location>
            <begin position="136"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002235-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="283" mass="32526" checksum="E8A040870AC5C9F0" modified="2016-09-07" version="1">NIDHKLKLRSKKGQLPFVEVNGEEIADSTIIMQELATRYDKDLDAALTQEQRNIAHAMISMLENHLVWVVLSWRSKNTEQMLKGYKINLQHALGSRLPNALLNFFFKFQFSRKGAKKVKAQGLGVHKPEEIEEFGRKDLKVLSELLADKPFFFGDEPTTLDCVAFSVLAQIHFILDEVKYGLKEFMQENCPNLVGHVSRIKERCFPDWEDICTKLDLNAHIPKPEPETKENKEGADTEKTAEQDKNESEKELEKDNSNEKSDKKEEPEKVVEENKEKEEAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5R5</accession>
    <name>A0A182P5R5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5R5"/>
    <dbReference type="STRING" id="199890.A0A182P5R5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002256-RA">
        <property type="protein sequence ID" value="AEPI002256-PA"/>
        <property type="gene ID" value="AEPI002256"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002256"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="226"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="711"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="502"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="574"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002256-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="794" mass="91091" checksum="96A2D86D3B0F5190" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P609</accession>
    <name>A0A182P609_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P609"/>
    <dbReference type="STRING" id="199890.A0A182P609"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002350-RA">
        <property type="protein sequence ID" value="AEPI002350-PA"/>
        <property type="gene ID" value="AEPI002350"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002350"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="6">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="5">
        <location>
            <begin position="300"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002350-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="526" mass="58388" checksum="DCC67523BC832D60" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6B5</accession>
    <name>A0A182P6B5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6B5"/>
    <dbReference type="STRING" id="199890.A0A182P6B5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002463-RA">
        <property type="protein sequence ID" value="AEPI002463-PA"/>
        <property type="gene ID" value="AEPI002463"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002463"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043562">
        <property type="entry name" value="RAX/RAX2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46271">
        <property type="entry name" value="HOMEOBOX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46271:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="447"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="122"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002463-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="497" mass="54573" checksum="2DE4F99B1C9F0B21" modified="2016-09-07" version="1">MNASTLCDSSDATDLSASPLSQIKLCDQQQMMAKAQLPVNYGLGSPSSPDKYQQQLANYQSHIKSLDLVAASSLEPSSPQSALHHQLPSHHHLHHHHNHQHPPAVPHLHQHPAHHHAHLQQHLHQQQQQHQQQQQQHLPHQLPSPTHPSQHPLALHHAQHPALGQQPPHPSLAELEYMKTLKETNKYFIDRSYRSLAGYGGVRGGPEGPPEDGTGTSASGGGAPGGGEYEEDLSSPIGAGSGNASGSLKRKYDRTRDGEERPGGGNGGNGDGGVHLPDGSESNPTSDSSINKYNKLHESADKSIRANSFDYMKNFDELRARQAAAYDAEQHHHHHQQQQQQQHHHQQLQALHQQQQQTQQHLSQSQHPQQTSPSSGQLGTGAGTNPGSDEYNPHRQSADSGADKGTEDGGVSYASSEELNQTTSSEQGEKVGSGSDDEGGDDNCSKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6F3</accession>
    <name>A0A182P6F3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6F3"/>
    <dbReference type="STRING" id="199890.A0A182P6F3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002501-RA">
        <property type="protein sequence ID" value="AEPI002501-PA"/>
        <property type="gene ID" value="AEPI002501"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002501"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000249">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF89">
        <property type="entry name" value="FI02132P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="245"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002501-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="513" mass="56140" checksum="0909C58D08D37A01" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6P7</accession>
    <name>A0A182P6P7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6P7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002595-RA">
        <property type="protein sequence ID" value="AEPI002595-PA"/>
        <property type="gene ID" value="AEPI002595"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002595"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21253">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21253:SF0">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002595-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="358" mass="41149" checksum="202EA3360F7EAAEE" modified="2016-09-07" version="1">MFSTHILYGVLAVGFFLCVLEAVPSDKGSPRSGGNRVLSRKRRFLLFPPGANFISGTLINHSMSLISSCNLLQVTISGGKGSLFETPRGYNLVAEMDMYHPLPDYMYHATSLRLGEIALYPNEQTTTAKPTPVPTIPLDHYGHELTQHELDVYLAKHPEAWVPLNWAKERIDWSGTKVNGMKYLTQSAQHTTPPVTYQSWKKKLWESTGNDRLYYSQQPLKRVRSLQEAREEAIEPSLWTEANHLNISHHLGWEHFHHYRDRRSLFDHLETTVPSFFGFHMRECLLRSICEARNLLPPKGRSMTADILRVIFTYPLKADLADEYSEMMRADKPNCRQLFSERCPLSILQLILFGKFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6Z6</accession>
    <name>A0A182P6Z6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6Z6"/>
    <dbReference type="STRING" id="199890.A0A182P6Z6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002696-RA">
        <property type="protein sequence ID" value="AEPI002696-PA"/>
        <property type="gene ID" value="AEPI002696"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002696"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002696-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="317" mass="32845" checksum="5D314981A1905569" modified="2016-09-07" version="1">MSLQNDTDPATNSGYGSSDETASLLVMAGTNSSSTTTTSGSSIISTINRPKMASHSSFNGPTMATAGAIAGPSNNLSQTALTTTVGTANKPILIRQDRTSTYLASPQLSATGLGGSEESATGEDDQHNARSVPDIELHCRLEAPAIAVSASCHSDGGSGGRIAISERAASTGSGTGGYQLIPYNRCRACRNCDRRASTTPMSSLKLTRSISKESVRSALHSRLTVQHSTIPPVLITSSPTSGSRIIRQSSQPEASTLSCCANQCAHACSMPSSSLRQLREPGDGIAGIAADSMRINGGMRQFKQVSFACMQLAAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6Z7</accession>
    <name>A0A182P6Z7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6Z7"/>
    <dbReference type="STRING" id="199890.A0A182P6Z7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002697-RA">
        <property type="protein sequence ID" value="AEPI002697-PA"/>
        <property type="gene ID" value="AEPI002697"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002697"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002697-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="265" mass="30448" checksum="430AF6C7574CCD62" modified="2016-09-07" version="1">MNRICLLRKLITTQIAVSILVLTFNPIVQYIFQGERVLAYTILIPFTDPEITSHFLLNLALQYFLLTVGIGGFSAAESVLILFVTSVAGFADVLKNKIDEMNTLLLDAEDTKDRTQVKLKLREIILLHQRVLEYENDLEKRYYLNNWVQVASSVFNLTGAIFGCYVSNSFTMYVLAFAVVVQIFELCCFGTILGIKNDEIEQAFYNSLWYLMDRAEKKDFLIMFHKSQHAMEMTVASMAPLNVVLFIAIMQKIYAFAMMMMRFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P740</accession>
    <name>A0A182P740_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P740"/>
    <dbReference type="STRING" id="199890.A0A182P740"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002742-RA">
        <property type="protein sequence ID" value="AEPI002742-PA"/>
        <property type="gene ID" value="AEPI002742"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002742"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002742-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="95" mass="10961" checksum="A848864180F19EE2" modified="2016-09-07" version="1">MGGWFHGNLSAKEAEKLILERGKNGSFLVRESQSKLSDFVLSVRADDKVTHVMIRWHSMTALMLMLFLLNMSRRSNDLGTLVRRNDDDDDDDYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P745</accession>
    <name>A0A182P745_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P745"/>
    <dbReference type="STRING" id="199890.A0A182P745"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002747-RA">
        <property type="protein sequence ID" value="AEPI002747-PA"/>
        <property type="gene ID" value="AEPI002747"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002747"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022727">
        <property type="entry name" value="Cuticle_C1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11018">
        <property type="entry name" value="Cuticle_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012249668" evidence="3">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002747-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="126" mass="12809" checksum="57590C3F85A2F90A" modified="2016-09-07" version="1">MKILLLLGLIAVVRAAPGYYGDHGLSYVAAAPAPIVKYAAPAVSVVHAAPAPVLKYAVAPAPIVKAVAPAATSYATIHQVHAPVVHAAPVVKYAAPAPVVSYVQSAPVVAHAPAPLLKYAPAYHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P800</accession>
    <name>A0A182P800_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P800"/>
    <dbReference type="STRING" id="199890.A0A182P800"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003053-RA">
        <property type="protein sequence ID" value="AEPI003053-PA"/>
        <property type="gene ID" value="AEPI003053"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003053"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN MOHAWK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003053-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="510" mass="57483" checksum="C983127B6770056C" modified="2016-09-07" version="1">MDKPSRPVRNRKRSRKAWPPGDSHRPVKRLFTPEIKRMLKDWLVRRRENPYPNREEKKLLAGETGLTYTQICNWFANWRRKLKNSGNDPLRKTWGNLIKNYNTNARGNVEQFSICSNDSIWGENGEESLDSRTSDSGEHPYSNHPSTANQHHHHHHHHHRSHLRHSQHQSLSSNAKCESKDDGTQYRQTYATDAGDCIGDNNNSDSCRNNNIDCRAFPGYMRVPEYGRLEDCPSSEGLRESYPPTAFRIDHCYTPRNYDTVFGLPEDTRCYKVTQFDGSYDPESGAGLEPIILTATPAHYGPTFTTGEIPNGGTLYLTPTTTLAPAVPPTIPHGRSRSSKYKSSIMEKYLRDLGELESSDEPADEPATMMPVLMATIPFQQKHCVHARSHVGLQLQAQPAISYDTAVLRGPPSLSKWLESAAKFTPSKHNYIDWECNGKQSTAKKRYDAVGNYYTIADADEGNDGCTYAAPLYGEPIPPGAASLEHQKDELDAAEALTKLANNFRTKFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P819</accession>
    <name>A0A182P819_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Solute carrier family 3 member 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P819"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003072-RA">
        <property type="protein sequence ID" value="AEPI003072-PA"/>
        <property type="gene ID" value="AEPI003072"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003072"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031984">
        <property type="entry name" value="SLC3A2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16028">
        <property type="entry name" value="SLC3A2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Solute carrier family 3 member 2 N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003072-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="150" mass="16117" checksum="98D8F12AB2C403A0" modified="2016-09-07" version="1">MTINERTTLLPKEYQKTYSITIPQDDLNNNVSNSSDNGVLCEYDSYALTKDELNKYIDDPWWIKMRYGCFATCWIVCLIALGISLYIAADALQHDTCGTPLTNNGTVSPAVLSLPGSSIVSSSPSPLADVPAGSTPPSSIVLTLLGQPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8H9</accession>
    <name>A0A182P8H9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8H9"/>
    <dbReference type="STRING" id="199890.A0A182P8H9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003232-RA">
        <property type="protein sequence ID" value="AEPI003232-PA"/>
        <property type="gene ID" value="AEPI003232"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003232"/>
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    <sequence length="1207" mass="130583" checksum="EE3013C63F5BDD6B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8J4</accession>
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            <taxon>Pterygota</taxon>
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            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Epiroticus2</strain>
        </source>
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                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="1">Epiroticus2</strain>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35599" checksum="06BE94CC4F69C755" modified="2016-09-07" version="1">MWCYRTVRIASGGTLRRMTSSDSRSSTSAQNVCLSLVRNHDKENFLCTLLLKNPERRSALAVRAFNVEVAKVSEKVSAGNVGVMPLKFWENTLTTLYRSGGTEEGKSSSTVPDHPVIHELHRAIREHKLSKRYLQRLVMARANANLHFVTVRQLEDYAEQTVSSVLYLLLEVHGMRNVHCDHAASHLGKAQGIVNLLRSIPYQTRRNAVPIPQEVLMEHGVNQERMVRNRADDKGVEEVTFSLASVAFRHLETAKGLLKTVPRPVRPIFLPAVSIERYLARLRHASFHLTDASVMRTDSLLPLVLYWRKLRGSY</sequence>
</entry>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
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            <name>a divalent metal cation</name>
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        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
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    <dbReference type="EC" id="3.1.4.-" evidence="10"/>
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    <dbReference type="STRING" id="199890.A0A182P8X7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003381-RA">
        <property type="protein sequence ID" value="AEPI003381-PA"/>
        <property type="gene ID" value="AEPI003381"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000004">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
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    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
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        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
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        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
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        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="3" id="KW-0140">cGMP</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDEase" evidence="12">
        <location>
            <begin position="376"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="739"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="865"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="452"/>
            <end position="456"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
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            <position position="603"/>
        </location>
        <ligand>
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            <label>1</label>
        </ligand>
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        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003381-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="883" mass="99045" checksum="785EE739EE8406B5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9C0</accession>
    <name>A0A182P9C0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P9C0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003525-RA">
        <property type="protein sequence ID" value="AEPI003525-PA"/>
        <property type="gene ID" value="AEPI003525"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI003525"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908:SF1">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003525-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="670" mass="76621" checksum="0D323459F62FE960" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9F0</accession>
    <name>A0A182P9F0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc carboxypeptidase A 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9F0"/>
    <dbReference type="STRING" id="199890.A0A182P9F0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003555-RA">
        <property type="protein sequence ID" value="AEPI003555-PA"/>
        <property type="gene ID" value="AEPI003555"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003555"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000002">
        <property type="entry name" value="Carboxypeptidase A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF153">
        <property type="entry name" value="ZINC CARBOXYPEPTIDASE A 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131017" description="Zinc carboxypeptidase A 1" evidence="16">
        <location>
            <begin position="25"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="120"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="534"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003555-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="830" mass="93827" checksum="682CBD480C94BA13" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9I4</accession>
    <name>A0A182P9I4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the troponin C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9I4"/>
    <dbReference type="STRING" id="199890.A0A182P9I4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003589-RA">
        <property type="protein sequence ID" value="AEPI003589-PA"/>
        <property type="gene ID" value="AEPI003589"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003589"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000273">
        <property type="entry name" value="troponin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000103">
        <property type="entry name" value="Troponin C Ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039508">
        <property type="entry name" value="KASH5_EF-hand-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14658">
        <property type="entry name" value="EF-hand_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003589-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="169" mass="19408" checksum="1960B12BD4452BA3" modified="2016-09-07" version="1">MKLICFLYYFLSSFTNMPQDDEEQRMLIMRKAFQMFDTQKTGFIETIKISTILNTMGQLFDEGELQDLIDEEDPESTGRVNFDGFANIASNFLQEEEDAEAMQQELKEAFRLYDREGNGYITTSTLKEILKALDDKLSNEDLDGIIGEIDTDGSGTVDFDEFMEMMTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9J7</accession>
    <name>A0A182P9J7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lebercilin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCA5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9J7"/>
    <dbReference type="STRING" id="199890.A0A182P9J7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003602-RA">
        <property type="protein sequence ID" value="AEPI003602-PA"/>
        <property type="gene ID" value="AEPI003602"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003602"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026188">
        <property type="entry name" value="Lebercilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028933">
        <property type="entry name" value="Lebercilin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16650">
        <property type="entry name" value="C21ORF13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16650:SF6">
        <property type="entry name" value="GH21622P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15619">
        <property type="entry name" value="Lebercilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lebercilin" evidence="5">
        <location>
            <begin position="37"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="452"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="49"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003602-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="579" mass="66005" checksum="9B10F780C653FE6A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAP6</accession>
    <name>A0A182PAP6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
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    <dbReference type="STRING" id="199890.A0A182PAP6"/>
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        <property type="gene ID" value="AEPI004001"/>
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    </dbReference>
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        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
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            <end position="536"/>
        </location>
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            <end position="613"/>
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        </location>
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            <end position="27"/>
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            <end position="86"/>
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            <end position="212"/>
        </location>
    </feature>
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            <end position="400"/>
        </location>
    </feature>
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            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
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            <end position="720"/>
        </location>
    </feature>
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        </source>
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        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004001-PA"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="746" mass="79237" checksum="A0E72620E4DB4287" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAT8</accession>
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        <recommendedName>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
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            <location evidence="1">Nucleus</location>
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        <text evidence="2">Belongs to the nuclear hormone receptor family. NR0 subfamily.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
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        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
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        <location>
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            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <end position="115"/>
        </location>
    </feature>
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            <end position="167"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004043-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="535" mass="58691" checksum="24E298440E15F539" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBV8</accession>
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        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBV8"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI004414"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0070382">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphatidylserine binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:SNARE binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="C2B_Synaptotagmin"/>
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        <property type="entry name" value="synaptotagmin-5 isoform X2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="synaptotagmin-5 isoform X2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="C2_dom"/>
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        <property type="entry name" value="C2_domain_sf"/>
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        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SYNAPTOTAGMIN BETA, ISOFORM D"/>
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    </dbReference>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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        <property type="entry name" value="C2"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="171"/>
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            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
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            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004414-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="543" mass="59380" checksum="A9AE592DC28E085E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC55</accession>
    <name>A0A182PC55_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PC55"/>
    <dbReference type="STRING" id="199890.A0A182PC55"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004510-RA">
        <property type="protein sequence ID" value="AEPI004510-PA"/>
        <property type="gene ID" value="AEPI004510"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004510"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
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        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004510-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="385" mass="39419" checksum="314AC49FA2FB92C3" modified="2016-09-07" version="1">MGQRSSDGDKLSPSSVSSSRGPAGLDHRTNSISALDDDDKLLDVVGPPQSPLLSLSQQMHHHASGWFNFEDVQRAEEAMRRRLQSDENERDGSDSNCSDSVSGSTGAFRPTSGSPKESSSSAGTSYPSPNISVGPPIHPPPHLLPYLYPHGLYPPPHLSLLHNPAAAAAMNPSLLFNAQLALAAQHPAFFGHYSGHSPTSPLHGLKGHRFSPYSLPSGLGSAFDAVTPGSNSAGARSLSSSPHPRAASNSPPTRPISVSPTPTQHPTSPTTADANAAANMPPGPNSSGGSILSPSQQPPPGAAPPPATQPPTTASMMAPGVAPPPPPPASLGPPPPPPPASNSPSELKSIEKMVNGLEVKHNINGSTVGVVDSNGGKGLHPAHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCV5</accession>
    <name>A0A182PCV5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex I-B8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase B8 subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCV5"/>
    <dbReference type="STRING" id="199890.A0A182PCV5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004760-RA">
        <property type="protein sequence ID" value="AEPI004760-PA"/>
        <property type="gene ID" value="AEPI004760"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004760"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR005822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004760-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="97" mass="11120" checksum="B1681A3DC7AD520B" modified="2016-09-07" version="1">MRLSLLRYARLNPAVKELRLHLCQTGEESKGVRDFVNTRYVQLKRDNPTLPILVRECSGVQPRLWARYELGKEKSVTLTNATAEDISKHIETLGKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD69</accession>
    <name>A0A182PD69_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PD69"/>
    <dbReference type="STRING" id="199890.A0A182PD69"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004874-RA">
        <property type="protein sequence ID" value="AEPI004874-PA"/>
        <property type="gene ID" value="AEPI004874"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004874"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="310"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004874-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="456" mass="51453" checksum="9C76A881BC3809A5" modified="2016-09-07" version="1">MSDSDTTDSDCGVRYKTTTTRHKHASLAPSSSRNHHSERTASYREEPRSNSSRYSSDRRRYRRSRSRSPDRRRHRRRSRSHDSPSRSRSKHYDTPRSSKSDGSPRKDTAGEKVLDISVSSVSSQDEQPEQQQQGMEMNPTEECFGPALPPSTLTTKPSNVQEEARDDTNQDDIIGPALPPHLLNRKAEAYTVEDTAREPRCIGPALPPGFSVTQASDNEHVSSESELSPFSEPEEDEDEEVGDIIGPLPGTSSSRVNVELEQRALELKIRQMEDAAAATANGGGSSAVPKAREDWMLELPDIRKISDMGLGARQFRTREKAEIGDRSVWTDTPADRERKKNSGGGSERSSKHADAATERERERERSLIAKRDKEQEKMVKQHKKKHKRDKTLLEIHQSKIKKEKQAISDGSEPTRRPFDRNLDLHANRFDDAQKKAIMKKAQLLNTRFSSGSSKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDG2</accession>
    <name>A0A182PDG2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDG2"/>
    <dbReference type="STRING" id="199890.A0A182PDG2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004967-RA">
        <property type="protein sequence ID" value="AEPI004967-PA"/>
        <property type="gene ID" value="AEPI004967"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004967"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03717">
        <property type="entry name" value="SOCS_SOCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12887">
        <property type="entry name" value="SPRY_NHR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000074">
        <property type="entry name" value="Neuralized protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000671">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NHR" evidence="14">
        <location>
            <begin position="10"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="13">
        <location>
            <begin position="218"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="577"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="655"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="712"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004967-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="91541" checksum="2BBF43FDD9EC92D5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDI3</accession>
    <name>A0A182PDI3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="9">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A182PDI3"/>
    <dbReference type="STRING" id="199890.A0A182PDI3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004988-RA">
        <property type="protein sequence ID" value="AEPI004988-PA"/>
        <property type="gene ID" value="AEPI004988"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004988"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000002">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020552">
        <property type="entry name" value="Inositol_monoPase_Li-sen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00378">
        <property type="entry name" value="LIIMPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004988-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="274" mass="29951" checksum="96BAB9DE52897631" modified="2016-09-07" version="1">MALNLDECYEHVLGLVETAGSLIASRNSQRKRVVEKSSNIDLLTETDQQVERMLMDGITAKYPDHKFIGEEETSEGKKAELTDAPTWIIDPVDGTMNFVHSFPHSCISIALLVEKVAEIAIIYNPIVGQKFTARRGKGAFLNGNPIRVSGETVFERALATTEFGTSREEEKTRVVLENIGKLVRQIHGLRSLGSAALNMAMVALGGADFNYEFGIHAWDIAAGDLLVREAGGVCLDPAGGPLDLMSRRVLCASSQALADKVVETLTQYYPEPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDM7</accession>
    <name>A0A182PDM7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDM7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005032-RA">
        <property type="protein sequence ID" value="AEPI005032-PA"/>
        <property type="gene ID" value="AEPI005032"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005032"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005032-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="407" mass="46975" checksum="BB9A75141C039CD1" modified="2016-09-07" version="1">MQIRGVLFRTSRALERLYRERDLFRPYELLLALPGFHLAEKFRAVPWKRALFLLSRAILLLQYVIWGNRFYLALADPSTRFGKALHYGNTFGVLTMMLARMLVVRWHLPSVRGLMEYLRRQRARTGSPVPKTHRTSYWKVVNIAITFQLIGLADRAVFCFSRTYRQELYEIPDNLAQLGWPMVAALHILSFDFATRWAAAYNVSLTGMNSIMMGLYDELEGIAQEYSELLAKGRDGEGIWTRFERNTARAVKRHETFLLQLDQLKPFLETTFLVMFYSAVLFLAMGTFIISASGTSTYGVILSGFLFALLLECYWCCQLVDRLNDVNAQIGMQLYSLEWPMELQYTESTGGRYRQARASLLIMMSKTQKTLGIRCGGMFEMSGEAFASLVKMTYTMLMFLRDTQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDN7</accession>
    <name>A0A182PDN7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EnsemblMetazoa" id="AEPI005042-RA">
        <property type="protein sequence ID" value="AEPI005042-PA"/>
        <property type="gene ID" value="AEPI005042"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005042"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00916">
        <property type="entry name" value="Npc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033916">
        <property type="entry name" value="ML_Npc2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF36">
        <property type="entry name" value="NIEMANN-PICK TYPE C-2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1949"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2036"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="1523"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="630"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="691"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="883"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1140"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1222"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1352"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="698"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="883"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1049"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1084"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1222"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1354"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1365"/>
            <end position="1376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005042-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2119" mass="229850" checksum="210B75F15A0AEC71" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGB6</accession>
    <name>A0A182PGB6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGB6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005975-RA">
        <property type="protein sequence ID" value="AEPI005975-PA"/>
        <property type="gene ID" value="AEPI005975"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005975"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029160">
        <property type="entry name" value="UQCC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35268">
        <property type="entry name" value="PROTEIN CCSMST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35268:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15013">
        <property type="entry name" value="CCSMST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005975-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="141" mass="16367" checksum="DAF32B110EA3D010" modified="2016-09-07" version="1">MLDTNRYHILPASANISSSTINRREQNPKEEVNNEPIKYFGSQASRWTAQRSREGPKGQDIPWFQPYVVNFSVAVFLIYFCILREENDIDEGLGRSLFEHVPGLEEKQLILSYHYNKENGLPTLDIENRMKELGMNFETAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGG6</accession>
    <name>A0A182PGG6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGG6"/>
    <dbReference type="STRING" id="199890.A0A182PGG6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006025-RA">
        <property type="protein sequence ID" value="AEPI006025-PA"/>
        <property type="gene ID" value="AEPI006025"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006025"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF39">
        <property type="entry name" value="GH23453P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006025-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="53828" checksum="AF0387568706913C" modified="2016-09-07" version="1">MRSDMHRSVSLDSRSSDEDTPLLAAPRLTSMAATAIAAAAAPAAPPSSTSEGAKVSSVVLADQIIYQSCVVTLGYDRALCAQLGTKSNSTDVAQLETIVQPYAAKITMVNTILMSVLPALCALFMGPWSDKYGRKPAMIVPSVGFITTYVMIGILSLLSKHFLVDPWCYVVAHIPAAILGGSTVLMAAIFSYLTDTTNESNRTVRIGILQACTMLGAFVGLLSSSFILQWTNVPTMFFLSAGTVSASSAFLYFCLEDSIKPDASMVHRQVREIFRLSHLCELLTTFFKKRSSYDRGIVWLTISIGVVTVLGAGGGTVFFLYTRRRFGWTIQEFTIWQAVELLSIVAGNVIGISVLKTLLKLPDIWLALLSVLNYALDALIKGLAQQGWELFLATGITPLKATEGAALMAICSAIIPSSEIAKFYSIAMALTNTVSLASAPLFTYIYNATVATSPQVFNFVSSGIFSLNVVLVGVIAVLLRKRRKAAQADPLFAQDSEILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGI5</accession>
    <name>A0A182PGI5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGI5"/>
    <dbReference type="STRING" id="199890.A0A182PGI5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006044-RA">
        <property type="protein sequence ID" value="AEPI006044-PA"/>
        <property type="gene ID" value="AEPI006044"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006044"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000611">
        <property type="entry name" value="Capricious, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131352" description="LRRCT domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="12">
        <location>
            <begin position="374"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="538"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="599"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006044-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="654" mass="72294" checksum="44746E24E7B625C5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGN7</accession>
    <name>A0A182PGN7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGN7"/>
    <dbReference type="STRING" id="199890.A0A182PGN7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006096-RA">
        <property type="protein sequence ID" value="AEPI006096-PA"/>
        <property type="gene ID" value="AEPI006096"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006096"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006096-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29105" checksum="ECB3564A02664FB1" modified="2016-09-07" version="1">MAATLMMALPTQKPRIGFSIESIVGSQKPESSERPASPLGDSAHFPGYPAGCREQPLPHQRAYLLQRQQQQEQQARELLALRERISQGSGDEFRLQDSPSSEGTPNRSASLRMIDLSSNSSRSSPPPHTRLSPECEPHPRAGHPTSPRSSPGPPPPTSSKGPIMVPGIPAGLVRPFPMVPNGELKPLPSFMPGGTAAELAVQAAHKQQLLAAQFQAALAHAHGQGAFGGHPATHLHPNHPANMPRESYPLYPWLLSRHGRNVFPPRFPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGV1</accession>
    <name>A0A182PGV1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homologue, RPL24.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGV1"/>
    <dbReference type="STRING" id="199890.A0A182PGV1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006160-RA">
        <property type="protein sequence ID" value="AEPI006160-PA"/>
        <property type="gene ID" value="AEPI006160"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006160"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="8">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006160-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="195" mass="23356" checksum="EBF5DAA2C4ABF07C" modified="2016-09-07" version="1">MRIETCFFCSNKIYPGHGMVFVRNDCKVFRFCRSKCRRAFNKKKNPRKIRWTKAYRKTHAKELTVDPSFEFEKRRNVPVKYDRELWTKTIEAVKKINEIKHRRECHFVMERLRKAREHEIHRDIVDVQKNIALIRSPAIGLKERRAKEEAQESALLMDVEDAEGEEEIQYVDARKLEKQLEESAGLTDDEEMLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHB6</accession>
    <name>A0A182PHB6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PHB6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006325-RA">
        <property type="protein sequence ID" value="AEPI006325-PA"/>
        <property type="gene ID" value="AEPI006325"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006325"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1322"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1448"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1554"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1614"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="709"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="911"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1334"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1344"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1387"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1471"/>
            <end position="1485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006325-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1649" mass="185483" checksum="3B44439A6A60FB27" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHJ5</accession>
    <name>A0A182PHJ5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS15m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S15, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHJ5"/>
    <dbReference type="STRING" id="199890.A0A182PHJ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006404-RA">
        <property type="protein sequence ID" value="AEPI006404-PA"/>
        <property type="gene ID" value="AEPI006404"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006404"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00677">
        <property type="entry name" value="S15_NS1_EPRS_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052137">
        <property type="entry name" value="uS15_ribosomal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46685">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46685:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="201"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006404-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="278" mass="33747" checksum="88016C338678E970" modified="2016-09-07" version="1">MNAFAKLKTITPTVNQIVRTYALKSDLKIKWVRPEKIPCYKPEKSGDLQALPKFAGTELMKDYRDSKELETANEHVRNLFTIQHNRRREMVENFKEDMVRRVYRHELDYGSIEAKLGLMTARIRSLQEYMEKFPRQSVVKVQLKELIDKRKRFLRYLRRWDYRRFEYMLEKLDLVYKPYPTHFHWITRKDSLRKLTTQHCEQIKETRLEEYRRQLESQQLEFLENKLKTLEFIRKEQTECQVPVTVSSEEIKTVRKQYEELKQKRAAAAESLKESEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHL5</accession>
    <name>A0A182PHL5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Indole-3-acetaldehyde oxidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>indole-3-acetaldehyde + O2 + H2O = (indol-3-yl)acetate + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18086"/>
            <dbReference type="ChEBI" id="CHEBI:30854"/>
            <dbReference type="EC" id="1.2.3.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="20">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="20">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHL5"/>
    <dbReference type="STRING" id="199890.A0A182PHL5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006424-RA">
        <property type="protein sequence ID" value="AEPI006424-PA"/>
        <property type="gene ID" value="AEPI006424"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006424"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050302">
        <property type="term" value="F:indole-3-acetaldehyde oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000013">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000003">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000008">
        <property type="entry name" value="Aldehyde oxidase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000003">
        <property type="entry name" value="Aldehyde oxidase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000012">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 20" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 20" id="KW-0408">Iron</keyword>
    <keyword evidence="12 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 20" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="21">
        <location>
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    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006946-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="125" mass="14046" checksum="47641A956D2EC0F9" modified="2016-09-07" version="1">MAHNCLTSREARIWPDSIPSRCPVSSILKSFRFKAFFLLVTSFQLLLLLLLPTLTGRWSMLKTPEGDWTLIPSAPQNFTVERILPSTDGTFLALAGPKGVSIIELPRRWGPNGQYQNGKECIICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ42</accession>
    <name>A0A182PJ42_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJ42"/>
    <dbReference type="STRING" id="199890.A0A182PJ42"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006956-RA">
        <property type="protein sequence ID" value="AEPI006956-PA"/>
        <property type="gene ID" value="AEPI006956"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006956"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000137">
        <property type="entry name" value="GD22965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF8">
        <property type="entry name" value="ACROSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="89"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006956-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="336" mass="36997" checksum="8BE4B03216F5A2E9" modified="2016-09-07" version="1">QTGSKWRLHDAPQRVGWGRSSRDFVNPPVAEQQVDVEECFNSVGPAACRSLTSALFYFCVHPSASRFPVCTNDNIPSLLTSLSASVNRIIGGEETEPHELPYQVSLQWNYNNDSITPMHYCGGALLSESWVLTAAHCKTSYTADGYMEVVAGAHNILNREEVNQRRKIEQIIIHERYCGTVCPYDIALIRVAEPFLVGDTVQPIKLPALNESFHGSALVSGWGATTPAMIPEYPEKLRKVVLPLVDYDECRQLWYDVSHLAATNVCAGPEDGSKASCSADSGGPLVTMNGTRVSEEPVLIGLVSWGPYPCAAPWRPNIFTGVAYFIDWIERHVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ82</accession>
    <name>A0A182PJ82_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Alpha-1,4 glucan phosphorylase</fullName>
                <ecNumber evidence="14">2.4.1.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Reticulon-like protein</fullName>
            </recommendedName>
        </domain>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Endoplasmic reticulum membrane</location>
            <topology evidence="2 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A182PJ82"/>
    <dbReference type="STRING" id="199890.A0A182PJ82"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006996-RA">
        <property type="protein sequence ID" value="AEPI006996-PA"/>
        <property type="gene ID" value="AEPI006996"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006996"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000005">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000153">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000197">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF13">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="16">
        <location>
            <begin position="214"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006996-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1187" mass="135429" checksum="0F1FB63DA3B36B9B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKB1</accession>
    <name>A0A182PKB1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PKB1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007377-RA">
        <property type="protein sequence ID" value="AEPI007377-PA"/>
        <property type="gene ID" value="AEPI007377"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007377"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000198">
        <property type="entry name" value="Blast:Protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000418">
        <property type="entry name" value="protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000021">
        <property type="entry name" value="Toll receptor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131577" description="TIR domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1234"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1343"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1234"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1343"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1430"/>
            <end position="1441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007377-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1452" mass="163615" checksum="7DF30E1D372B545B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKF0</accession>
    <name>A0A182PKF0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKF0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007417-RA">
        <property type="protein sequence ID" value="AEPI007417-PA"/>
        <property type="gene ID" value="AEPI007417"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007417"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009511">
        <property type="entry name" value="MAD1/Cdc20-bound-Mad2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053729">
        <property type="entry name" value="MAD2L1BP_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681:SF1">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06581">
        <property type="entry name" value="p31comet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007417-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="237" mass="26733" checksum="798CB3A5AB128434" modified="2016-09-07" version="1">MDAISIELEAPFITQACASKIVCTIVELLLYNRTQIPFPYPTFRAMVKKLETVELAEDIHQSVAEVRIQKQREKAQHMIKNVETLFDTLEKILIDHPAIGELMIVFGKTIYTAKEAFVVIMPTIDKNHFGTNHQRSLEKMLRKIGLQLTLCDQMVTGREATGDTNIFVALKSTSSLHPTYGVSCLDDFQLPKKCAKFVIILKTTPNGSKAIGHDCCKRLEVFSEEDMDRSPALSMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKF1</accession>
    <name>A0A182PKF1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ZNF277 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKF1"/>
    <dbReference type="STRING" id="199890.A0A182PKF1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007418-RA">
        <property type="protein sequence ID" value="AEPI007418-PA"/>
        <property type="gene ID" value="AEPI007418"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007418"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040048">
        <property type="entry name" value="ZNF277"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267">
        <property type="entry name" value="ZINC FINGER PROTEIN 277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007418-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="447" mass="52827" checksum="DE59B3BC504DE595" modified="2016-09-07" version="1">MNSSISNTYGDDDGEASKSTIIGPLNFNQDSSTDPPTSLVNERTVPCMFCSNIYDFHSTDNGSDQYLAHLYLIHRLVVADVKEIACLPSYCYYWKEKFTHDPVEKYCSSMLLNQLPDGTSSPNEKYFLLSDIEPLDYEVRQRLRREKLDLVLTRHQFERTDRRFNRGCLYCRDYRAETRPEYISHLYTKHFLLLGKPEHLVFVDELIEIVQDKLNRLICLFCEKLFKDRPTLKEHMRKKGHKRINPDNHYYDRFFLVNYRLKQKPEYVPIAQRKEESRVFASDSESDSDWSDWNGEEQTTTCLFCMHAEANIDSLKQHMVAKHKFNFDQTVTDLSFYQRVKIVNFIRRQMHIRKCIACGDQCQDYESLLKHLEDLDHFRLDKEASAWDQPEYFFPTYEDDQFLCHLEEVDNERDELSQEEGSVVISESVNASINLDAESLSLENFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKQ6</accession>
    <name>A0A182PKQ6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKQ6"/>
    <dbReference type="STRING" id="199890.A0A182PKQ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007523-RA">
        <property type="protein sequence ID" value="AEPI007523-PA"/>
        <property type="gene ID" value="AEPI007523"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007523"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007523-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="331" mass="35728" checksum="F88B8B9F19796E1C" modified="2016-09-07" version="1">MNNFLDISMQRFRCSVCDKSYLRKRHLQRHMRDECIGIPPRFHCDHCDSKFRRKYHLVRHMLSKHGIQMEPGPIKPGSGGSAANGGGSGSGTEGDELNYVKLAAEAGNGELATIAAAAAAAAAAAAATAPPPAKGKGGKGGNRGVTADSAVDDKYPEALKVKQEEIEPVSSESMMYQNFKNLFFDYALKNVPAAQMHTVTAAPSSSSSSTSTTSSLAVAGTVGGLVGGRRGGSSSSSLLDSGRRSLLQLNDFLYDVKFSDLSKFLNAVGRYQCPRRDCDKNYKDASSLQRHIRYECGGMKKFRCVMCGKAFSQGSHLKRHLESGVCIKYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL01</accession>
    <name>A0A182PL01_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PL01"/>
    <dbReference type="STRING" id="199890.A0A182PL01"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007618-RA">
        <property type="protein sequence ID" value="AEPI007618-PA"/>
        <property type="gene ID" value="AEPI007618"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007618"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01820">
        <property type="entry name" value="PAF_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT BETA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007618-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="225" mass="25909" checksum="C143CE4A85B1820C" modified="2016-09-07" version="1">MSATTLPAICKDLDGDDRWLSIHKRFVAECKEKDPDVMFIGDCILESLQFTDYWNQHFVPMHCLNFSIRTDRTQNILWRLQNGELDNVRPKAIVLHAGTNNIGDTAEEVTEGILELVRTIRQKLQDVYIILPTLLPRGQQPNELRDKNDQVNRLLRERCIGINKVQIVTVDSGLIQSDGTISHHDMFDYLNLTNVGCKKVFEPVCDLLHQILTENERERDLTPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL05</accession>
    <name>A0A182PL05_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PL05"/>
    <dbReference type="STRING" id="199890.A0A182PL05"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007622-RA">
        <property type="protein sequence ID" value="AEPI007622-PA"/>
        <property type="gene ID" value="AEPI007622"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007622"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF905">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="179"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007622-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="917" mass="102296" checksum="557430CF5E74FC88" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL91</accession>
    <name>A0A182PL91_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EIPR1-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIPR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PL91"/>
    <dbReference type="STRING" id="199890.A0A182PL91"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007708-RA">
        <property type="protein sequence ID" value="AEPI007708-PA"/>
        <property type="gene ID" value="AEPI007708"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007708"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000732">
        <property type="entry name" value="EARP-interacting protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040323">
        <property type="entry name" value="EIPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205:SF15">
        <property type="entry name" value="EARP AND GARP COMPLEX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205">
        <property type="entry name" value="WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="5">
        <location>
            <begin position="168"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007708-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="376" mass="42140" checksum="55BFC2C954500929" modified="2016-09-07" version="1">MEDNNSLVYGLEFQARALASQQAESNDVRFFVATQSLKPNNQLHVVDLNEDSSALQSRIFSHPYGEVWRLAASAHDPRLLASCYSLLKGNGQVVMETALLTLPESLEPKDGEQQQEFLSFEHMETLATEGYGVEIRTTEFHPTDPNQLACVVDGKIVLFNRAEAATRVVAEINAKNVPKFTTGRWSHFHQGNHFIALHDCSIKSYDVRDSNHVVWSIDEAHSQLVRDLDCNPNKQCHIVTGGDDGVLKVWDFRNTKEHVFARSDHHHWIWSVRFNTYHDQLILSSGSDGKVLLTCAGSVSSEAPEVITGDGGEQGAGGEPREHLADGLLQTFDQHEDSVYGVEWSTADPWMFASLSYDGRMIISKVPKQYKYQILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLC3</accession>
    <name>A0A182PLC3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLC3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007741-RA">
        <property type="protein sequence ID" value="AEPI007741-PA"/>
        <property type="gene ID" value="AEPI007741"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007741"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112:SF0">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131503" evidence="1">
        <location>
            <begin position="27"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007741-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="184" mass="21163" checksum="416D0D1DED0E7EFB" modified="2016-09-07" version="1">MSITMAIWQPCAVLCLVVACVEQTIAIKASYERFEQFFGNEYMDFDLRVRKFNRTTMTLNGTIFINQPIDDTILFTSDVFHSRLGNQQFQHYPQHLPTSGLCSFIDNLHRDYPSAIESIENITQMSECPVTERVMHVIDKAFPSEVIPDSLANGLWKMVFSGILNETTVIRFMISVRLTDDYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLC6</accession>
    <name>A0A182PLC6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLC6"/>
    <dbReference type="STRING" id="199890.A0A182PLC6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007744-RA">
        <property type="protein sequence ID" value="AEPI007744-PA"/>
        <property type="gene ID" value="AEPI007744"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007744"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112:SF0">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007744-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="127" mass="14841" checksum="650D7D3938C38B4D" modified="2016-09-07" version="1">MVTLNGSISLLVTLNKSHEISTDFFHSNLGNQQFNHYPVKLQTRDVCDFVDNFHDDYSQFVNDIINFPKKGKCPIEPRTVYVIDKPFPNKAIPTFFPSGLWKVYVMQKMDDVEVARFEIITKFKNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLD7</accession>
    <name>A0A182PLD7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLD7"/>
    <dbReference type="STRING" id="199890.A0A182PLD7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007755-RA">
        <property type="protein sequence ID" value="AEPI007755-PA"/>
        <property type="gene ID" value="AEPI007755"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007755"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48411">
        <property type="entry name" value="OS01G0948300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48411:SF1">
        <property type="entry name" value="OS01G0948300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="98"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007755-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="271" mass="31206" checksum="EAE1CFE7C6A9846C" modified="2016-09-07" version="1">MAQMVTMESIDLSDATISIPPEIQVDQIHIETPEESTTTENYCPEMIGHVLATHVGKRTRILDGSFTYVELMKHYHSSLDESEWQKENLYERLLRRAKTEDLSEVSGIGCLYQSGVDRLGRPVVVFCGKWFPAHNIDLEKALLYLIYLLDPIVKGDYVIAYFHTLTSSNNYPSLQWLKDVYSILPYKYKKNLKAFYIVHPTFWTKMMTWWFTTFMAPAIKTKVHSLPGVEHLYSAIAKDQLEIPAYITEYDMATNGIHYFQPITNTSSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLM2</accession>
    <name>A0A182PLM2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Caspase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLM2"/>
    <dbReference type="STRING" id="199890.A0A182PLM2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007842-RA">
        <property type="protein sequence ID" value="AEPI007842-PA"/>
        <property type="gene ID" value="AEPI007842"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007842"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990525">
        <property type="term" value="F:BIR domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045751">
        <property type="term" value="P:negative regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000001">
        <property type="entry name" value="Caspase-3 preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF245">
        <property type="entry name" value="CASPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="10">
        <location>
            <begin position="55"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="9">
        <location>
            <begin position="194"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007842-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32999" checksum="3C512780D437849E" modified="2016-09-07" version="1">MHGFTTMFNRKQDSSDTRRMPHGSPVASGSQMNGIIRPAYVIDRYAAYYPMNHKHRGMALIFSHNKYNVRNITLPMREGSAIDSKRLKETLELFKFDVKLYQDFKLEEIKTTLGQVSSMNHSDSDCILIAILTHGEDGDIVYAYDDLYDLSLVWSFFTADNCPSLAGRPKILLIQACRGNRLDHGVKVQKDGVARYSIPTHADFLFAYATIPGFMAFRNTTEGSWFINELCKELQENGHKYDLVTLLTFVTQKVAYDHESVSNVPEFNMRKQTPCIVSMLTRLLLFNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLU7</accession>
    <name>A0A182PLU7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLU7"/>
    <dbReference type="STRING" id="199890.A0A182PLU7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007919-RA">
        <property type="protein sequence ID" value="AEPI007919-PA"/>
        <property type="gene ID" value="AEPI007919"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007919"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007919-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="67" mass="7481" checksum="BD5F91AE5479DD6D" modified="2016-09-07" version="1">MGCTSSAEERAAIARSKQIERNLKEDGIQAAKDIKLLLLGKLLYTHTYLTEPYRLPSCTSSSVLHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM93</accession>
    <name>A0A182PM93_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SYO1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PM93"/>
    <dbReference type="STRING" id="199890.A0A182PM93"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008066-RA">
        <property type="protein sequence ID" value="AEPI008066-PA"/>
        <property type="gene ID" value="AEPI008066"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008066"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13394">
        <property type="entry name" value="Syo1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="2">
        <location>
            <begin position="401"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008066-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="656" mass="73323" checksum="6A461C8C6FDA9905" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMD5</accession>
    <name>A0A182PMD5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PMD5"/>
    <dbReference type="STRING" id="199890.A0A182PMD5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008108-RA">
        <property type="protein sequence ID" value="AEPI008108-PA"/>
        <property type="gene ID" value="AEPI008108"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008108"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000180">
        <property type="entry name" value="Member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008108-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="216" mass="23597" checksum="93C262EA1ECA3A10" modified="2016-09-07" version="1">MASSPRAGGAAQRPNGATQNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTLCIDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDIQNSDSFARAKTWVKELQRQASPNIVIALAGNKADLANSRVVDYEEAKQYADDNGLLFMETSAKTAVNVNDIFLAIAKKLPKNEGAGPQQNIRPTQNETNRQNSGCCAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMM5</accession>
    <name>A0A182PMM5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMM5"/>
    <dbReference type="STRING" id="199890.A0A182PMM5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008199-RA">
        <property type="protein sequence ID" value="AEPI008199-PA"/>
        <property type="gene ID" value="AEPI008199"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008199"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000015">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000128">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000056">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1093"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1123"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1162"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="18">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="17">
        <location>
            <begin position="267"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="857"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="903"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008199-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1196" mass="134656" checksum="3384AC133FAE047C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNE6</accession>
    <name>A0A182PNE6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNE6"/>
    <dbReference type="STRING" id="199890.A0A182PNE6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008473-RA">
        <property type="protein sequence ID" value="AEPI008473-PA"/>
        <property type="gene ID" value="AEPI008473"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008473"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
        <property type="term" value="P:heme export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF4">
        <property type="entry name" value="GH15861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008473-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21391" checksum="D7DB8892A422935C" modified="2016-09-07" version="1">MDLKHSNVPEVTVVADAYMPGSKSSDLIKPPATNGSNATLDKPALPAGEFRMYKRRWLVLAIFVMYSASNALQWIQYSIIANIVQRYYNITSTWVDWTSMIFMILYIPLIFPASWILDKLGLRIAAISGVLGTCLGAWVKCFSVSPDLFWVGFVGQSIVAASQVFILSLPAKVAAVWFGPDQVSSACSIGVFGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNK9</accession>
    <name>A0A182PNK9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aprataxin C2HE/C2H2/C2HC zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNK9"/>
    <dbReference type="STRING" id="199890.A0A182PNK9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008536-RA">
        <property type="protein sequence ID" value="AEPI008536-PA"/>
        <property type="gene ID" value="AEPI008536"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008536"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008536-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20897" checksum="67563FC25BE4CA98" modified="2016-09-07" version="1">MTSTEEGFARLVREHWSYQLVRELEDESFHLKSTDKSIAIRDLHPKARVLEDFGLEKKQFNFGYHLKPHMKRLHMHVISKDFVSPSLKRRHHWTIFNSEIFQSHEAVFAELKLHGKIRERPDSYIKALREGPLNCAVCGYVTDKLCIMKQHIAVHEYSTVETVVAESRSNHLSHSGHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNS2</accession>
    <name>A0A182PNS2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histone-lysine N-methyltransferase Suv4-20</fullName>
            <ecNumber evidence="3">2.1.1.362</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61992"/>
            <dbReference type="Rhea" id="RHEA-COMP:15556"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60348"/>
            <dbReference type="Rhea" id="RHEA-COMP:15555"/>
            <dbReference type="Rhea" id="RHEA-COMP:15556"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.362"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.362" evidence="3"/>
    <dbReference type="STRING" id="199890.A0A182PNS2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008601-RA">
        <property type="protein sequence ID" value="AEPI008601-PA"/>
        <property type="gene ID" value="AEPI008601"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008601"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140941">
        <property type="term" value="F:histone H4K20me methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19186">
        <property type="entry name" value="SET_Suv4-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1700:FF:000001">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000006">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025790">
        <property type="entry name" value="Suv4-20_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044426">
        <property type="entry name" value="Suv4-20_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51570">
        <property type="entry name" value="SAM_MT43_SUVAR420_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="17">
        <location>
            <begin position="141"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP93</accession>
    <name>A0A182PP93_9DIPT</name>
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        <submittedName>
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            <taxon>Culicoidea</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="1">Epiroticus2</strain>
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    <sequence length="147" mass="17183" checksum="7E51A5DDF6810F0C" modified="2016-09-07" version="1">MSILSQMKHLPLQTKPLSRPFWGWVNMMFNRVDRSRLKKELDGTDSGIMHIGFEHLEGLSRLRKVVLHNCVYIDDQALWKLRYVAHTLEEVQISKCGNVTDHGLLQLKQLSHLQQVKTFELSDVKNMEEVEKKLKQALPNCKFDMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
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    <reference evidence="24" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
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                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
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        </reaction>
    </comment>
    <comment type="cofactor">
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
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    <dbReference type="AlphaFoldDB" id="A0A182PPP5"/>
    <dbReference type="STRING" id="199890.A0A182PPP5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008924-RA">
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        <property type="gene ID" value="AEPI008924"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:trans-Golgi network"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07541">
        <property type="entry name" value="P-type_ATPase_APLT_Neo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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            <begin position="98"/>
            <end position="120"/>
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            <end position="1147"/>
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        <location>
            <begin position="530"/>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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    <sequence length="1163" mass="130544" checksum="B4E3EB0F0F6BAE30" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ15</accession>
    <name>A0A182PQ15_9DIPT</name>
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        <recommendedName>
            <fullName evidence="8">GHMP kinase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">Epiroticus2</strain>
        </source>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009045-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="206" mass="22828" checksum="000131A075016D13" modified="2016-09-07" version="1">MSLPYASSNLDTEHIPFDAPDLAILICNTNVKHELSSSEYPVRRKQCQEALQLMGLQSYRDATLEHLQALGNANELLVRRARHVITEIERTQAAAEALKEQNFVKMGQLMTESHKSLSEDFDVSCYELDLLVEATVAIRGVLGSRMTGGGFGGCSVTLVERAALADVVKEMDVIYSRKTGGKYRARFYLAQPGDGARSIEVAEYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQA0</accession>
    <name>A0A182PQA0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQA0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009130-RA">
        <property type="protein sequence ID" value="AEPI009130-PA"/>
        <property type="gene ID" value="AEPI009130"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009130"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009130-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="139" mass="15442" checksum="DD257E9EE8380BDD" modified="2016-09-07" version="1">MSTPLTTICDSTMRTLSQNTQPQLFTAFMARWRENRTIFNTPNPRLMNVSLLRDNKLLHGQERRGSRMSVRLPSRQPSMASLRPHSPNASIGSRRGSRGSSNASATSTKSNRSATHHTKDNGNAHPNESVTVEIAEIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQA6</accession>
    <name>A0A182PQA6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQA6"/>
    <dbReference type="STRING" id="199890.A0A182PQA6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009136-RA">
        <property type="protein sequence ID" value="AEPI009136-PA"/>
        <property type="gene ID" value="AEPI009136"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009136"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000119">
        <property type="entry name" value="Solute carrier family 7 member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009136-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42808" checksum="992EF32D59AFAE8A" modified="2016-09-07" version="1">AIVALTFAQYAVRPFFEDCEAPENAVRLLAAVCLCFLTAINCISTKWAMKIQDVFTIAKLTALVSIILAGMYFMATETLDNFQNPWEGDYALSSLAYAFYSGLFAFGGWNYLNFVTEELENPYKNLPRAIWIAMPMVTGIYVFVNMAYFAVVSRQEMLASIAVAVSFGNRMFGSVAWLIPIFVALSTFGGVNGILFTSARLFSTGAQEGHLPAWFSLVHVDRQTPIPALIFTCITSIIMLLSANVFVLINYFSQILWLSVAASIAGLLWLRISKPNMPRPIKVNLALPIIFLVCCLGLVLLPSFTEPFNLLVGLAITLSGVPVYYVCIVWRNNKQSKNAIMQWIERGCQILFNAAFVDCHHDRKREREFSEMQTSIEDKSVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQF9</accession>
    <name>A0A182PQF9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine rich immune protein (Coil-less)</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQF9"/>
    <dbReference type="STRING" id="199890.A0A182PQF9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009190-RA">
        <property type="protein sequence ID" value="AEPI009190-PA"/>
        <property type="gene ID" value="AEPI009190"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009190"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001054">
        <property type="entry name" value="AGAP007467-PA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001220">
        <property type="entry name" value="AGAP007471-PA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009190-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="91253" checksum="816BE91FB3A23B96" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR08</accession>
    <name>A0A182PR08_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PR08"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009389-RA">
        <property type="protein sequence ID" value="AEPI009389-PA"/>
        <property type="gene ID" value="AEPI009389"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009389"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04011">
        <property type="entry name" value="C2B_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04018">
        <property type="entry name" value="C2C_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000138">
        <property type="entry name" value="Fer-1-like family member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000034">
        <property type="entry name" value="otoferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000054">
        <property type="entry name" value="otoferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037720">
        <property type="entry name" value="C2B_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037722">
        <property type="entry name" value="C2C_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF60">
        <property type="entry name" value="MISFIRE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2056"/>
            <end position="2076"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="335"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="495"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1030"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1211"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1564"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1808"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1391"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009389-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2087" mass="233590" checksum="8CBBBD4DE7B2091A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR27</accession>
    <name>A0A182PR27_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine protease HTRA2, mitochondrial</fullName>
            <ecNumber evidence="5">3.4.21.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">High temperature requirement protein A2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th/Diap1 by directly inducing the degradation of th/Diap1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.</text>
            <dbReference type="EC" id="3.4.21.108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.108" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PR27"/>
    <dbReference type="STRING" id="199890.A0A182PR27"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009408-RA">
        <property type="protein sequence ID" value="AEPI009408-PA"/>
        <property type="gene ID" value="AEPI009408"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009408"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.120:FF:000004">
        <property type="entry name" value="Serine protease HTRA2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939">
        <property type="entry name" value="SERINE PROTEASE FAMILY S1C HTRA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939:SF129">
        <property type="entry name" value="SERINE PROTEASE HTRA2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="PDZ" evidence="20">
        <location>
            <begin position="372"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009408-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="428" mass="46246" checksum="7E71BBBD35427D76" modified="2016-09-07" version="1">MQCALKRTGLFYQQHRLLAVAQRAAQESLRSIGGTAPNTTPERCSDRSGTGEGAGRSEARWKLGISATFALAGVFGLLACTQTDERRKRREAYPWPFRLLPTVSASTRSNRKQYNFIADAVEISAPAVVYIEIRDRQHVDFFTREPVTVSNGSGFIIEPDGLILTNAHVVVSKPHTLVTVKLPDGRTFPGQVEHVDPTSDLATVRIRCGGLPTLRLGRSADLRPGEWVVALGSPLALNNTVTAGVVSSTQRASQELGLRGKDINYIQTDAAITFGNSGGPLVNLDGEAIGINSMKVTAGISFAIPIDHAKQFLRKINEQQGGGDGRGGSIGAPGYRRYIGVTMLSLTPDILHELRQRNHNFPPNVQGGVLVGGLQPGDIITHINGKQIKNSGDVYELLTKDQQQKLTIVVYRGQQPTTLQVIAEDTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRE7</accession>
    <name>A0A182PRE7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GTP-binding protein Rhes</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRE7"/>
    <dbReference type="STRING" id="199890.A0A182PRE7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009531-RA">
        <property type="protein sequence ID" value="AEPI009531-PA"/>
        <property type="gene ID" value="AEPI009531"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009531"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000475">
        <property type="entry name" value="GTP-binding protein Rhes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF7">
        <property type="entry name" value="GTP-BINDING PROTEIN DI-RAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009531-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35057" checksum="DF7E5DE5023758FE" modified="2016-09-07" version="1">MMIDFVQTTSSQRLPIKIVRELTELFSAHSHSAPVRPLNDTIALLDAMPGTCHRLRIPSIVSSRSAKSGVGASTSSTSSSSAGVSTTEDDLFGCEGMLPSSPPATVKKERHRVTMMGAARVGKSSIISQFLYEKYLSRYKQTIEEMHRGEYELPDGSSLTLDILDTSGSYQFPAMRALSINTSGAFILVYAVDDEETWNEVERLREQIISVRGTRVPIVIVGNKADVPEEDRQVPFKVARSRALLEWGCGYAECSAKNNEGILTVFKQLLRQANIEYNLSPAVRRRRKSLPSYTGATNPARANSAKYYLKRHSCSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRG1</accession>
    <name>A0A182PRG1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRG1"/>
    <dbReference type="STRING" id="199890.A0A182PRG1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009545-RA">
        <property type="protein sequence ID" value="AEPI009545-PA"/>
        <property type="gene ID" value="AEPI009545"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009545"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14445">
        <property type="entry name" value="RILP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1770:FF:000005">
        <property type="entry name" value="RILP-like protein homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF4">
        <property type="entry name" value="RILP-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161256">
        <property type="entry name" value="RILP dimerisation region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RH1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="5">
        <location>
            <begin position="265"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="162"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009545-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44743" checksum="25673A1C91133706" modified="2016-09-07" version="1">MNVAEKFTVVDVYDLALEIGKEFETIIDANGVNAVSGLITKVVNALELMETLTCQNESENATLQELQEKIAQLEAEKEQKAASRSRYEKELEAIEDQWRTEAKELFKVIDKLQEENRKLQRGIAQSASENTNQNDERSRNSTTNDGFRNESEMPEAEGVLKKSEYKLQLSQLEEKLKRKEMELCEKMAEIESLSSQNDRLKKVVSESRRRQKLSHNQIITLCEERADFLAQIQDQHHEIKALRMQLGLAEKENEDLANRVNEDERPRFSTVELKEMLTDRNELKARVSDLEQELMTCQAIGSGTDTESKPNAFAKEPSNEGPTIDFSELPVQGPLPYEPDDAPWKKSSESGIRKFFRKLFNETSSDCSSFSQRSLSTLSKMALSSGPHSDIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRM5</accession>
    <name>A0A182PRM5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRM5"/>
    <dbReference type="STRING" id="199890.A0A182PRM5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009609-RA">
        <property type="protein sequence ID" value="AEPI009609-PA"/>
        <property type="gene ID" value="AEPI009609"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009609"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009609-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="786" mass="89787" checksum="058058E9B18EB153" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRU7</accession>
    <name>A0A182PRU7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRU7"/>
    <dbReference type="STRING" id="199890.A0A182PRU7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009682-RA">
        <property type="protein sequence ID" value="AEPI009682-PA"/>
        <property type="gene ID" value="AEPI009682"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009682"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131675" evidence="1">
        <location>
            <begin position="23"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009682-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="373" mass="33993" checksum="6528DCC50029ED5D" modified="2016-09-07" version="1">MKQHILTTALLAVCFLTGPTLAQGGIGVGVGGIGVTVLGTSSLVGVTVATTVAAGATTTTAAPTTTTAAPATTTVAGATTTVAGATTTVAGATTTVAGATTTAATGNTVVFNINGTTTASTTTAAATTTTAATTITITINIDGQTVTVSASDSSLLSILTQILNSQTTTTTAATTTTNAATTTTTAAATTTTAASRGGCGGRGGVGRLGIGFGAGIGFRGGFRGGFRGGAGGGIGFGIRGGVRGPGIIRPIVGAAANAAGNVVGAAVNAAGNIVGSGLNLASGVIGGAANAASGILGGIGSAIGGIGTGLQAAAGGALNGGLRAGANSQVGPTGGRGGFGAGFGTGFSGGVGSRGLFGGGLQAGVGFRAGLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSW2</accession>
    <name>A0A182PSW2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PSW2"/>
    <dbReference type="STRING" id="199890.A0A182PSW2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010048-RA">
        <property type="protein sequence ID" value="AEPI010048-PA"/>
        <property type="gene ID" value="AEPI010048"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010048"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131911" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="67"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="187"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010048-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="294" mass="31285" checksum="7668CB68BC733D86" modified="2016-09-07" version="1">MMNLKHLLMLAVCLLPALLVTPGSGRAVVLDPDTALGASAAASSSSSSSSSEGAGSVRGDGGRAIRPTFVKITSAPPARVAQIRGTTVELECEIMGSPTPTVQWVHGSGQTADWEDISVNVITEDTPTSVARVVTRLVIDRASRASQSTFTCIGRTAGQEVSSSTIVYHVDSVAHLGNFSDMPLLRPAAAVDSMFKNLKGARITLHYKTLFENMGSTVVLPCKAVGRPLPEITWLNEEGNVVGSLQDPRFRTLPTGELIITGLRWADMGSYTCVAKNVLSKDETETFVYPIRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSZ0</accession>
    <name>A0A182PSZ0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSZ0"/>
    <dbReference type="STRING" id="199890.A0A182PSZ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010076-RA">
        <property type="protein sequence ID" value="AEPI010076-PA"/>
        <property type="gene ID" value="AEPI010076"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010076"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF11">
        <property type="entry name" value="BESTROPHIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="703"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010076-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="84984" checksum="187CB5BCB1710B09" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSZ2</accession>
    <name>A0A182PSZ2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PSZ2"/>
    <dbReference type="STRING" id="199890.A0A182PSZ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010078-RA">
        <property type="protein sequence ID" value="AEPI010078-PA"/>
        <property type="gene ID" value="AEPI010078"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010078"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131847" description="UPAR/Ly6 domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010078-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21295" checksum="525CB7AFA36FB601" modified="2016-09-07" version="1">MIPTKSLISCAVFASVLLLVFQNGMALKCRNCLSSKSFDECEKMGGIVECNATIVNTNHETFKPENPTLPVGNWTEFKCYRFEVARLYPNNSDTGLRGYGRGCTFLQVNFCNGWSSSLNFTNCSTCTTDNCDENPSIIPTASPGVTTTTLPVTSTAPVNSSTPAPTSTKKPSNGANVLTLHNLSSLSFLGVLLLFAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PT39</accession>
    <name>A0A182PT39_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PT39"/>
    <dbReference type="STRING" id="199890.A0A182PT39"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010125-RA">
        <property type="protein sequence ID" value="AEPI010125-PA"/>
        <property type="gene ID" value="AEPI010125"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010125"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF356">
        <property type="entry name" value="FI05912P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="244"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="413"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="741"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="775"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010125-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="85839" checksum="F34EBFE6D963DED4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTG7</accession>
    <name>A0A182PTG7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PTG7"/>
    <dbReference type="STRING" id="199890.A0A182PTG7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010253-RA">
        <property type="protein sequence ID" value="AEPI010253-PA"/>
        <property type="gene ID" value="AEPI010253"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010253"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22384">
        <property type="entry name" value="KH-I_KHDRBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF140">
        <property type="entry name" value="GH05812P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010253-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="115" mass="13122" checksum="BEF79CF7CBECD6D9" modified="2016-09-07" version="1">MLDITRDRPIKIAVRVQVPVRDHPKFNFVGKLLGPKGNSLKRLQEETMCKMAVLGKGSMRDRKKEEELRLSGDPRYAHLSEDLHVEISTYTAPAEAHARIAYALAEVRRFLVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTP9</accession>
    <name>A0A182PTP9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTP9"/>
    <dbReference type="STRING" id="199890.A0A182PTP9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010335-RA">
        <property type="protein sequence ID" value="AEPI010335-PA"/>
        <property type="gene ID" value="AEPI010335"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010335"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031984">
        <property type="term" value="C:organelle subcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09258">
        <property type="entry name" value="AP-1_Mu1A_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000002">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="12">
        <location>
            <begin position="167"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010335-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="422" mass="48402" checksum="AEA5ABAFC257BD44" modified="2016-09-07" version="1">MSSSAIFILDAKGKVLISRNYRGHIDMGVIDKFMPLLMEKEEEGLITPILQTPECTFAYVKTNNLYLVSVTRSNANIALVFVFLHKVVQVFTEYFKELEEESIRDNFVVIYELLDELIDFGYPQTTDSKILQEYITQEGHKLEIQPRIPMAVTNAVSWRSEGIKYRKNEVFLDVIESVNLLANANGNVLRSEIVGAIKMRVYLSGMPELRLGLNDKVLFESTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIERHAHSRVEYMIKAKSQFKRRSTANNVEIVIPVPADADSPKFKTTIGSVKYAPEQNAITWTIKSFPGGKEYLMRAHFGLPSVECEDSEGKPPIQVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUM1</accession>
    <name>A0A182PUM1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ankyrin repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUM1"/>
    <dbReference type="STRING" id="199890.A0A182PUM1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010658-RA">
        <property type="protein sequence ID" value="AEPI010658-PA"/>
        <property type="gene ID" value="AEPI010658"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010658"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000302">
        <property type="entry name" value="Ankyrin repeat containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF25">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="9">
        <location>
            <begin position="150"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010658-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="434" mass="49853" checksum="4186DB7C07D97ED4" modified="2016-09-07" version="1">MTDSFPLHECVFNGDTRKLSCLLRTHEIAEKDKHGNTPLHLAVMLGKKECIFLLLAHGAPVKVKNSQGWSPLAEAISYGDRQIISSLLRKLKQQAREQMEQRRPNLVKALKQMGDFYMELKWDFHSWVPLISRILPSDVCKIHKSGCSIRLDTTLVDFSDMRWERGDISFIFKGENPPKDSLTALDNECRCYQHVRHEETEMEIEDEVDILMSSDILAAQMSTKGISFTKAQSGWIFREDRRETVAGQYDSDLYTINGLTLEQRKRREHLSRDDLQKNKALMESLTKGGQGQQGGIDQNGEIYRRESLQPPPNCEVTWQKYVSAEPGQYPNLGRELVYKESSKNFKATVAMSKDFPLSVDMLLNVLEVIAPFKHFSKLREFVTLKLPSGFPVKIDIPILPTVSAKITFQKFEFRDDISPDLFVIPEDYKEDTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUU3</accession>
    <name>A0A182PUU3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 50A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUU3"/>
    <dbReference type="STRING" id="199890.A0A182PUU3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010730-RA">
        <property type="protein sequence ID" value="AEPI010730-PA"/>
        <property type="gene ID" value="AEPI010730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010730"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010730-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17983" checksum="330C98E9E5DD2453" modified="2016-09-07" version="1">MAIMESIRQSYWIVSLSRRTILATVVAALLFFSGWWIIIDTASVYETSFNFSYYICGILATISFIMVNAVSNEMLHGTGALYTGGIIGGGGIKVFLFIGFVLGFTSIIAAVWIMIAEFAVNETRTDKYPGYALLMHNVFIFLATLIYKFGAQTENEYLNGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVU0</accession>
    <name>A0A182PVU0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynein heavy chain linker domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVU0"/>
    <dbReference type="STRING" id="199890.A0A182PVU0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011077-RA">
        <property type="protein sequence ID" value="AEPI011077-PA"/>
        <property type="gene ID" value="AEPI011077"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011077"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="2">
        <location>
            <begin position="711"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="838"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011077-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="886" mass="103624" checksum="C0A5D111BDEC198B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVU4</accession>
    <name>A0A182PVU4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVU4"/>
    <dbReference type="STRING" id="199890.A0A182PVU4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011081-RA">
        <property type="protein sequence ID" value="AEPI011081-PA"/>
        <property type="gene ID" value="AEPI011081"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011081"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF14">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="445"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011081-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="584" mass="68639" checksum="D8D933A8CD3AB0AD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWI7</accession>
    <name>A0A182PWI7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWI7"/>
    <dbReference type="STRING" id="199890.A0A182PWI7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011324-RA">
        <property type="protein sequence ID" value="AEPI011324-PA"/>
        <property type="gene ID" value="AEPI011324"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011324"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011324-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="92" mass="10011" checksum="A7DA2716E322B600" modified="2016-09-07" version="1">MRSIACSEMKTLDDEGLLTLLGEAERMLNSRPLTYIPLDSEESEALTPNHCLLGNSCGSKPLLEHDCMNPMASGKILERPAVKVAKIEIGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX89</accession>
    <name>A0A182PX89_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PX89"/>
    <dbReference type="STRING" id="199890.A0A182PX89"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011576-RA">
        <property type="protein sequence ID" value="AEPI011576-PA"/>
        <property type="gene ID" value="AEPI011576"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011576"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00034">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000031">
        <property type="entry name" value="Heterochromatin protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011576-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="92" mass="10640" checksum="F8FAA172CD31D8F8" modified="2016-09-07" version="1">MSHKSNSNDDDSKQVVVNVAEVMNGFEKGYVPEKILGATKDDNELLFLMQWKDKDKAQLVKSKEARKHCPQLVLDFYEKHLNWPAFDQSEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYX5</accession>
    <name>A0A182PYX5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYX5"/>
    <dbReference type="STRING" id="199890.A0A182PYX5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015043-RA">
        <property type="protein sequence ID" value="AEPI015043-PA"/>
        <property type="gene ID" value="AEPI015043"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015043"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20617">
        <property type="entry name" value="CYP1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303:SF31">
        <property type="entry name" value="CYTOCHROME P450 307A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303">
        <property type="entry name" value="HEME-BINDING MONOOXYGENASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015043-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="566" mass="64827" checksum="2054BDB46C154611" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYY9</accession>
    <name>A0A182PYY9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYY9"/>
    <dbReference type="STRING" id="199890.A0A182PYY9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015057-RA">
        <property type="protein sequence ID" value="AEPI015057-PA"/>
        <property type="gene ID" value="AEPI015057"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015057"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015057-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="537" mass="60802" checksum="CEFB58F336245750" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ60</accession>
    <name>A0A182PZ60_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZ60"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015125-RA">
        <property type="protein sequence ID" value="AEPI015125-PA"/>
        <property type="gene ID" value="AEPI015125"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015125"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015125-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="397" mass="45333" checksum="B05120075264A4FB" modified="2016-09-07" version="1">MLLKFSINFNLLLSYTTGLVPFRYNFHKRRFDTCKPCEPFAALLLILLAGVQYKLGRLPGRMKIPKVGMQNIIHMGKNLILNGNCVLIAEQQLLFLDTYRQLLTDLLTRVHSLARRRTVGLAMQVQLFTQLVLLPCATYTLHVSIYITLVEWSEINIVHGVLFMVSLIPNIAHVNNFYALLFMQRVMLGEINDKLNNVWTICIRTKASNKLNSMSHCLQIHLYEYQQCASSVQKLLPYYSLSVALYLLILFQELLSKVASLIFYQFTHYYTLSNGYPSPNMLAVVGVATISVYGINTFQLFSLCFAMSEESLRIKSTVHRLSLIPGQDKYFHDTVKTFLMSLNHSMLKITIAGMFTMDFELLAGMLAAISNFVVLLMQFHIDYSKSKMSFASHPAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZB1</accession>
    <name>A0A182PZB1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZB1"/>
    <dbReference type="STRING" id="199890.A0A182PZB1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015176-RA">
        <property type="protein sequence ID" value="AEPI015176-PA"/>
        <property type="gene ID" value="AEPI015176"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015176"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF187">
        <property type="entry name" value="CYTOCHROME P450 4AE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015176-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="510" mass="58873" checksum="AF2D988D888958D3" modified="2016-09-07" version="1">MFLVLLATLLGIVFTWVVLTIIRNRATVSDLKKRLPNFNVIPAIPMLGSAYHFKDPTPEGIFNTFTGFHQKYGKNLIAQGLFNAPSMQICDPKVIEQVMQARTIEKTIIYDFMIPWLGTGLAISTGAKWAQRRKIITPTFHFKILEDFLVVMNHQTDLLIEKLKKNANSKDFDIYEHVTYCALDIISESAMGVKLNTQQQPNSEYVMAVKEISDIILKRLFSFLREYPWAFQFTKAHRRQEELVKIVHSFAYKVISERKKQLQDETERRRTQEKLEEEDVYGKRRMTLLDLLLNVTIDGKPLSDTDIREEVDTFMFAGHDTTTSCISFAAYYLSRDEVIQQRVYDEIQDVVGPNAKTQELTYGILQELKYLDMVIKETLRINPSVPIIGRRSAGDMVIDGVTIPKGMDFGILIYALHNDPELYPNPDRFDPERFSEEASEKRQPYSYIPFSVGARNCIGQRYALLEIKTMLVKLVVNYRLLPCDERNKLQIKTDMTLKPVNGAFIRIVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PKY2</accession>
    <name>A0A240PKY2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PKY2"/>
    <dbReference type="SMR" id="A0A240PKY2"/>
    <dbReference type="STRING" id="199890.A0A240PKY2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015241-RA">
        <property type="protein sequence ID" value="AEPI015241-PA"/>
        <property type="gene ID" value="AEPI015241"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015241"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012082829" description="Serpin domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="131"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015241-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="505" mass="57233" checksum="191BD26C15008DFC" modified="2017-10-25" version="1">MIWILLVVALATQASCQRYKGTTMVTKDEFCKFNQIRQWDCEDQFATFLDANPHIERCSLSLPIYSDRCSSLAAVTQPTERPAPCSGNNCKNYATRLSESASAVRQPSANDNLEVPKPSIRYDRKVMDFSLKLFQKAFPEDDTSNYIISPLMVQSLLSYLYDGASNATRLEMESVLQLNMNDLHDIDRALKPHSEQGPITKNKLDTASQIFKATTIELLPAFRESLKRNRVPLDEMDFSNPRLASQTINNWAKEKTRQRITEVVDEQSIDPETKLFLLNALYFNGTWMNKFPKTERGSFYVSGQPPQRSSVNMMFLTKELRNGNTRTDDSANGLTWVELPYDGDSISMILFLPNERFQLDRELRHFTVQDLQTILTEIEQDETSKVMLQLPEFKAESTVSLVEPLKTLGIASMFGDSKPFDQLSSDNVKISDVKQKSFLTVNPHGTVATSVTTATVIPLSITRSLIFKADQPFALIIMDKQNKLPLFFAKISQPLKVKGEKANRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PL12</accession>
    <name>A0A240PL12_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine rich immune protein (Coil-less)</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A240PL12"/>
    <dbReference type="STRING" id="199890.A0A240PL12"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015336-RA">
        <property type="protein sequence ID" value="AEPI015336-PA"/>
        <property type="gene ID" value="AEPI015336"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015336"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012783097" description="Leucine rich immune protein (Coil-less)" evidence="3">
        <location>
            <begin position="19"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015336-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47923" checksum="25C8AA03620A1395" modified="2017-10-25" version="1">MTLLSIYRLLLVLHTVHRFGSMRLQCSREFCYFYDLTSNEDTFAYRYIPPNVDILTVENALMEHLDHSMLQGVPSFIDHVMVTNSYALRWVSVPKAVNSLMISTSSLQRIDIETNSTLSYLGIAVCNLVKVPITVQNAQMLEWLHITSCKLQGLNLASLCENGRLRVLNLMANKIRYVVNTSTRYCALYDTLASLTLSENLLTTVNMELFNVLGRMDSLHLQNNKIRALLGQLIHSMLAEVRLDGNKLKDVDLCEWVVPSLSIILLDRNNITMIPKCVKNITSVSMLTLRSNRLSTFTIESLAGMNALRELDISCNKLTTVTLSTEHFPADLEVINMDYNNLTALDLSFIPARSLEVRVSYNLISRFDVNATSRNVSQLSMYQNPIICAWHTPFLWGRDRCNQTDGSVLLVHNEHLRNACHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWK6</accession>
    <name>A0A3F2YWK6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWK6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015447-RA">
        <property type="protein sequence ID" value="AEPI015447-PA"/>
        <property type="gene ID" value="AEPI015447"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015447"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF19">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="131"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015447-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="410" mass="46280" checksum="88D0DF83ABFF96CC" modified="2019-01-16" version="1">MAVAPGLEWIDREYFTRVLETYLHADVTVQRYELAAGCPGGQNFMSAIVRATVHYTLASAKPEGPPETVSLIVKTKLSNPELAEGADQLNVFGIEKNVYGAVLKAVRELLTSFGDCTQFAPRFIYEDEHALVLEDLAAKGYRQPDRRARLDQPHMRLIVQKLAKFHAATAVLGRKNRDLFNELGSSSFSTEGNPIHLFYTYAIDHCIDQTERVPELRQYTDSLRSFLDHAIDREAKSYECDKAGFNVLNHGDMWLNNLLWKYDSDGAVTDVIMVDYQESFYGSPAFDLSHLLYSSANSELQRAGFDELVQLYADELRDALRQFKYDGPLPDLERVRSEMASKRDHALIVTTCIVPPLILENSELATPENMVGDHEEAVRAREEIFSNPKFIEILTILLPRLIGDEVANKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWK8</accession>
    <name>A0A3F2YWK8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWK8"/>
    <dbReference type="STRING" id="199890.A0A3F2YWK8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015452-RA">
        <property type="protein sequence ID" value="AEPI015452-PA"/>
        <property type="gene ID" value="AEPI015452"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015452"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="361"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="727"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="821"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015452-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="846" mass="92054" checksum="A2CC549FA465CA89" modified="2019-01-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZF3</accession>
    <name>A0A182NZF3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZF3"/>
    <dbReference type="STRING" id="199890.A0A182NZF3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000033-RA">
        <property type="protein sequence ID" value="AEPI000033-PA"/>
        <property type="gene ID" value="AEPI000033"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000033"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14316">
        <property type="entry name" value="UBA2_UBAP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1920:FF:000004">
        <property type="entry name" value="GG24751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1920">
        <property type="entry name" value="UBAP1 SOUBA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038870">
        <property type="entry name" value="UBAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042575">
        <property type="entry name" value="UBAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023340">
        <property type="entry name" value="UMA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15960">
        <property type="entry name" value="LD44032P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15960:SF5">
        <property type="entry name" value="LD44032P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51497">
        <property type="entry name" value="UMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UMA" evidence="3">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="632"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000033-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="74093" checksum="A749C279A22A5106" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZX3</accession>
    <name>A0A182NZX3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZX3"/>
    <dbReference type="STRING" id="199890.A0A182NZX3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000204-RA">
        <property type="protein sequence ID" value="AEPI000204-PA"/>
        <property type="gene ID" value="AEPI000204"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000204"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="72"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="286"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="610"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="910"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000204-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1182" mass="138115" checksum="A3A9C5BD37426A92" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0E6</accession>
    <name>A0A182P0E6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0E6"/>
    <dbReference type="STRING" id="199890.A0A182P0E6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000378-RA">
        <property type="protein sequence ID" value="AEPI000378-PA"/>
        <property type="gene ID" value="AEPI000378"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000378"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000378-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="500" mass="56437" checksum="2C99F60E4C3BAC4B" modified="2016-09-07" version="1">MGNIVVRSRLLENMNNYEHEEVGDGDFELLRHSVRLFNDIQLNDDEDSTHGSGSEFASILRHLIRSGEIMVLNYESYMSHPLPTIKKKPSLDKLKNNDIYHSTKSASGVLQDAVEGAATTETGPISLMSMVTQRQYGLGKRKGPFESSEMCRISNHFRPNTFTETVSACDTKVFCGKFTSNGDRFVTASQDTWVRVYDSSRSQYKLLSLLDTKHVSWSILDMDFSPDGKSFVYSTWADALFISSMDREVSDSIHALYLSPNNQKLGVFTVCYSGCGKYILCGANDGALYAYDLEANRRSFMVPVARVDRDVNTVGYVEEMSNIFYSGSDDGVIKIWDRRCIDDSSPIPVGTLIGHFDGVTYIDSRNDGRYIISNSKDQSIKLWDLRAMTSSNARPGTVRNNWDYRWDDVPKHFFNVKRSLKGDTSIMTYRGHKVQKSLIRAKFSPASTTGQRYIYTGCGTGRLIIYDVLTGNIEEAIEGHHDIVRDVAWHPHRTEIITCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0K2</accession>
    <name>A0A182P0K2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0K2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000434-RA">
        <property type="protein sequence ID" value="AEPI000434-PA"/>
        <property type="gene ID" value="AEPI000434"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000434"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000434-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24199" checksum="447E1932C0257FF1" modified="2016-09-07" version="1">MNSLNQKSTYSISATWGSHVVSVTQFQTSTCADRQAPGIICATCSTVAVCVKVGSVWETNFVEACNADEGLYCNEFDGGCSTSVGSCNPAGQGNFECNSPGVFPDPFNCRLYHMCFLNGNNPVAIGMDCGGAAFSPATGDCSLSLNDTVCLAPQFNCSSVGQMAPWPGNNNIYYICAAETVNGNRVLRPRLYRCPSNQMFLDGRCVQRDWSNMPPEICIYFTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0Z2</accession>
    <name>A0A182P0Z2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CYRIA/CYRIB Rac1 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYRI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0Z2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000574-RA">
        <property type="protein sequence ID" value="AEPI000574-PA"/>
        <property type="gene ID" value="AEPI000574"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000574"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039789">
        <property type="entry name" value="CYRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12422">
        <property type="entry name" value="GH09096P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000574-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="263" mass="29776" checksum="9671ABE9F9186E76" modified="2016-09-07" version="1">GAGKEIREAIADPSPECQEKAWNIVIPLVEKLKRCYEHSLELERIVPKLLGQLVGGRLNPTQHLETQQALVKQLAEILEFVLKFDEYKMKTPAIQNDFSYYRRIASRQRLDQTSEMIISTELANRMSLFYAHATPMLKVLSEATSKFVQDNSDNVDNTTETLGTMAKVCLRMLENPKLLAQIEREETHLLLLRVMVGLVILYDHVHPVGAFARGAHVDVKGCVRLLQAQPAVKAEPLLNALRYTTKHLNEDNTPKNIRNLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1M8</accession>
    <name>A0A182P1M8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1M8"/>
    <dbReference type="STRING" id="199890.A0A182P1M8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000810-RA">
        <property type="protein sequence ID" value="AEPI000810-PA"/>
        <property type="gene ID" value="AEPI000810"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000810"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038948">
        <property type="entry name" value="POLR1D-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34769">
        <property type="entry name" value="RCG42593, ISOFORM CRA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34769:SF1">
        <property type="entry name" value="RNA POLYMERASE I AND III SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000810-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="169" mass="18923" checksum="42FF8E729E61EC10" modified="2016-09-07" version="1">MIPGVVRKAAVAKQKEPVGKVNDTRQLNVQNTQKGIIPGSVRPVASKKCLNKCPAAVAALAPATKILRETRLGKVRAEEHGSTAWRPCPLRKTNKRFLNRTVLSIVKHNHREKQKTSHRSKLKLTELVRKANETSRERSRKPSKSKHHESHTNTDESHPTVIDLAEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1Y5</accession>
    <name>A0A182P1Y5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1Y5"/>
    <dbReference type="STRING" id="199890.A0A182P1Y5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000919-RA">
        <property type="protein sequence ID" value="AEPI000919-PA"/>
        <property type="gene ID" value="AEPI000919"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000919"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026182">
        <property type="entry name" value="ANAPC15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22526">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX C SUBUNIT 15, PSEUDOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22526:SF2">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX C SUBUNIT 15, PSEUDOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15243">
        <property type="entry name" value="ANAPC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000919-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="122" mass="13835" checksum="24ABAB633F4522FF" modified="2016-09-07" version="1">MIPFYPSLQPSVAYNFWFSVDESYDDDEEVNTLEAEHTEWLNRITLIGQDLTPIGKSSNEQHMENMDTEDEDANDESDDSDNSDDDDDDMDDMNNTRGNLPDEITVVTGGYMGDELQPADTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P392</accession>
    <name>A0A182P392_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P392"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001376-RA">
        <property type="protein sequence ID" value="AEPI001376-PA"/>
        <property type="gene ID" value="AEPI001376"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001376"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130774" evidence="3">
        <location>
            <begin position="26"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001376-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="421" mass="46863" checksum="A804FF3F3887AFDB" modified="2016-09-07" version="1">MEPSSAMHALYLLLVCLLLCRVSRGEWVEIQQLKPSSPAVTSTISTTIKPATINGHVLAHSHLLLSHLSDDRERLGGRWSSSGGGTVSSSSMQWHRPVSDLLDYDGQGKRVSHPVPAWITTTTRQHVYAQHTPVTLVNVSNKVEELNDNESDQEENDEQYPIVQTELLPFGNRYEEESIESVTDTGAPKAIIHAAASPGVEHHFDDFDDYDERLPLAQTEGKPPDSAEEEYVEEEEPYETEEGQGIDEQPEPPKKLHVRPAAPMGLGGFLEFLRRMQASFVQRTAHTIGDKIRTLAGMRDQLLSTIERRISALWRGDPPQTGGKRRVRRGWMEPHADTEAMDFPSAEGALLTISFLTFAVFLIKLVLQVINTIKAKHYTYSTFAAATPVSGGLLVKRTRRHTLDPHELQALLGALDGFRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3K6</accession>
    <name>A0A182P3K6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3K6"/>
    <dbReference type="STRING" id="199890.A0A182P3K6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001491-RA">
        <property type="protein sequence ID" value="AEPI001491-PA"/>
        <property type="gene ID" value="AEPI001491"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001491"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009622">
        <property type="entry name" value="NDUFAF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338:SF4">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338">
        <property type="entry name" value="UPF0240 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06784">
        <property type="entry name" value="UPF0240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001491-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21976" checksum="09CD26D1DB370FD3" modified="2016-09-07" version="1">MGKVMSVVGRQAQRFNVENRAQKVISQAKPKPAPKFESNLRDLERVLKEHPEIVAEQSRKNVMLDENLRQVYVTSKDVMIDPKAAQKQDPDKPLPINRTSVEEYEFGHLEPRTVTKGRCTLRQAVQFIGNHQTDPSQWTAAKIAEYYNMKEALVKNILDHFKSFEVHLPDKNLERRRVLTRAAESTKQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3V5</accession>
    <name>A0A182P3V5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(3E,5Z)-octadienoyl-CoA = (2E,4E)-octadienoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45244"/>
            <dbReference type="ChEBI" id="CHEBI:62243"/>
            <dbReference type="ChEBI" id="CHEBI:85108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA = (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45224"/>
            <dbReference type="ChEBI" id="CHEBI:85090"/>
            <dbReference type="ChEBI" id="CHEBI:85091"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3V5"/>
    <dbReference type="STRING" id="199890.A0A182P3V5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001591-RA">
        <property type="protein sequence ID" value="AEPI001591-PA"/>
        <property type="gene ID" value="AEPI001591"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001591"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001591-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="316" mass="34906" checksum="C096F7EE2031D743" modified="2016-09-07" version="1">MSKLAFGAIFSTLKTIARPGVAPLARNLCAATNTSTDASTKYNFKTLKLSTPSPFVVHVEFNRPDRMNAFNRQLWTEIKDCFEQLHNDPDCRVVVLSGGSSKHFTAGIDLFDMMKLGQEMGAIEEVGRRGRLLEGTIKLYQDCISSLEHCYKPVIVAVHSACIGAGLNLITAADVRYCTRDAWFSLKEVDIGLAADVGALQRFPRAVGNQSWVRELAFTARKFASDEAYSHGLVSRMFDNREELLQGAIKLAEEIASKSPIAVQGTKKNIVYSADHTIQEGLDHIRGINMLNLQSEDFLNAIMASQSKETPLFAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4K9</accession>
    <name>A0A182P4K9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4K9"/>
    <dbReference type="STRING" id="199890.A0A182P4K9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001845-RA">
        <property type="protein sequence ID" value="AEPI001845-PA"/>
        <property type="gene ID" value="AEPI001845"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001845"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000023">
        <property type="entry name" value="CSON002431 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF190">
        <property type="entry name" value="T-BOX TRANSCRIPTION FACTOR TBX20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001845-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="85" mass="9801" checksum="26DB01A4793BDE92" modified="2016-09-07" version="1">MLEIVLNSMHRYQPRIHLARLGPGQNIPITPKELADVDHKTYVFPETIFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4M7</accession>
    <name>A0A182P4M7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4M7"/>
    <dbReference type="STRING" id="199890.A0A182P4M7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001863-RA">
        <property type="protein sequence ID" value="AEPI001863-PA"/>
        <property type="gene ID" value="AEPI001863"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001863"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130785" evidence="1">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001863-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="86" mass="9589" checksum="AD7756FBB0294A71" modified="2016-09-07" version="1">MSPAFLAVIAVILCILFRILNVSSTPQIPSIVCKDGQFMECFNKIAPMLREPSFSITNGTNTTSRRPGLCPFRKRSLDRSLKAKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P647</accession>
    <name>A0A182P647_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P647"/>
    <dbReference type="STRING" id="199890.A0A182P647"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002395-RA">
        <property type="protein sequence ID" value="AEPI002395-PA"/>
        <property type="gene ID" value="AEPI002395"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002395"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000516">
        <property type="entry name" value="ets DNA-binding protein pokkuri"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000061">
        <property type="entry name" value="Ets DNA-binding protein pokkuri"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF201">
        <property type="entry name" value="ETS DNA-BINDING PROTEIN POKKURI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="6">
        <location>
            <begin position="85"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="496"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="382"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="806"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="351"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="740"/>
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        </location>
    </feature>
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            <end position="839"/>
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        </location>
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    </feature>
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        <location>
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            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002395-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="98389" checksum="C74DA5F714D5E185" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6J0</accession>
    <name>A0A182P6J0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6J0"/>
    <dbReference type="STRING" id="199890.A0A182P6J0"/>
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        <property type="gene ID" value="AEPI002538"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002538"/>
    <dbReference type="Proteomes" id="UP000075885">
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130898" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002538-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="66324" checksum="D8347225A606C561" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6T4</accession>
    <name>A0A182P6T4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6T4"/>
    <dbReference type="STRING" id="199890.A0A182P6T4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002634-RA">
        <property type="protein sequence ID" value="AEPI002634-PA"/>
        <property type="gene ID" value="AEPI002634"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002634"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000082">
        <property type="entry name" value="Leucine-rich repeat-containing 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051963">
        <property type="entry name" value="Adhesion_GPCR_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930:SF4">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="307"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="625"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002634-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="799" mass="86310" checksum="CD50FA00B8653618" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P728</accession>
    <name>A0A182P728_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P728"/>
    <dbReference type="STRING" id="199890.A0A182P728"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002730-RA">
        <property type="protein sequence ID" value="AEPI002730-PA"/>
        <property type="gene ID" value="AEPI002730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002730"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000082">
        <property type="entry name" value="OSM3-like kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF50">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002730-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="611" mass="69579" checksum="3C19EB246D3E55F8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7C8</accession>
    <name>A0A182P7C8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7C8"/>
    <dbReference type="STRING" id="199890.A0A182P7C8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002830-RA">
        <property type="protein sequence ID" value="AEPI002830-PA"/>
        <property type="gene ID" value="AEPI002830"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002830"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF147">
        <property type="entry name" value="EG:BACR7A4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131005" description="Peptidase S1 domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="58"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002830-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="683" mass="76191" checksum="2486FE4C90649A40" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7T4</accession>
    <name>A0A182P7T4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7T4"/>
    <dbReference type="STRING" id="199890.A0A182P7T4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002987-RA">
        <property type="protein sequence ID" value="AEPI002987-PA"/>
        <property type="gene ID" value="AEPI002987"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002987"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000437">
        <property type="entry name" value="Beat-IIIc, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF8">
        <property type="entry name" value="BEATEN PATH IA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002987-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="366" mass="39441" checksum="FA04744DCAB9A781" modified="2016-09-07" version="1">MEARSAPEPNPHYPARTSAAPLSHSVLGLESVHIQVPVAVLVGTSATLICECDLPDEDLYSVKWYKGKHEFFRYTSKEIPSIKIFPKAGISVNVNHSNASHLVLVNLEPQSSGKYSCEITEAAPSFHTKIATRTMNVVDLPAGEPQILELKPFYGAEEFLEVECRSGPSLPAPKLEWFVNDLPLHGPLQAPSRLEYGTQPASTRSSSSSSSSSSSSRKKQSANKSSLPAPTVPSTDGESRENELADLAPGRAQPMVAGTTTATSTTAGSQEPVPAANGTSGEHRKGAASNSRYELAVSRLKLLLEHGHFRNGKLKVEEKEVEEEEKKPTLPLVLLLISNAKTVVTKTTSTTNEVFPGGHWLENVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7V3</accession>
    <name>A0A182P7V3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DM5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7V3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003006-RA">
        <property type="protein sequence ID" value="AEPI003006-PA"/>
        <property type="gene ID" value="AEPI003006"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003006"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040003">
        <property type="term" value="P:chitin-based cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004145">
        <property type="entry name" value="DUF243"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927">
        <property type="entry name" value="FI07246P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927:SF16">
        <property type="entry name" value="LP07342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03103">
        <property type="entry name" value="DUF243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00690">
        <property type="entry name" value="DM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013334692" evidence="2">
        <location>
            <begin position="16"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="DUF243" evidence="3">
        <location>
            <begin position="112"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003006-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="275" mass="28445" checksum="DBA4E9B695623B25" modified="2016-09-07" version="1">MKVLVVLACVAIVVARPEPPVGGYNHHHHGGHGGHSGYNYAQPAPHNPAPVFGHQAQFSGSAATASTGGAFFDTLSAGGATGSFSGGAANAFSNANSFSQVNSASFAAPQQQIVQKHIYVHVPPPEPEQSFQQQIVAPGLRQKHYKIIFIKTPQVQPTAAQLALQQSQTEEKTIVYVLVKKPEALGDISLPAPAVTKPSKPEVYFIKYKTNTEEVQAPVGLGVSSSGVAQADATGGLGLLSSSGVAQATATGSAHSHSNVPAQSYGAPGHHHGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P820</accession>
    <name>A0A182P820_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P820"/>
    <dbReference type="STRING" id="199890.A0A182P820"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003073-RA">
        <property type="protein sequence ID" value="AEPI003073-PA"/>
        <property type="gene ID" value="AEPI003073"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003073"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000003">
        <property type="entry name" value="sodium/calcium exchanger 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF65">
        <property type="entry name" value="NA_CA-EXCHANGE PROTEIN, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="21">
        <location>
            <begin position="50"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003073-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="222" mass="23853" checksum="F74B35E3CFEDB8FA" modified="2016-09-07" version="1">MEGTVRDDDGENEGEDPPTPSCMDYIMHFVTLFWKIIFAFIPPTDMSGGYLCFVVSIFCIGVVTAIIGDVASHFGCTLGIKDSVTAIIFVALGTSIPDTFASKVAAIQDKYADASVGNVTGSNAVNVFLGIGVAWTIAACYHSFHGRSFDVEPGTLAFSVTLFCTEAFIAIIVLMIRRSPRIGGELGGPKKAKIVTSIFFFSLWIVYLLISSLEAYGIIKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8E9</accession>
    <name>A0A182P8E9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P8E9"/>
    <dbReference type="STRING" id="199890.A0A182P8E9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003202-RA">
        <property type="protein sequence ID" value="AEPI003202-PA"/>
        <property type="gene ID" value="AEPI003202"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003202"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000239">
        <property type="entry name" value="Transmembrane and TPR repeat-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000528">
        <property type="entry name" value="Transmembrane and TPR repeat-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44395">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44395:SF1">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003202-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="661" mass="74349" checksum="E34B95292CF571D5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8R6</accession>
    <name>A0A182P8R6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P8R6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003320-RA">
        <property type="protein sequence ID" value="AEPI003320-PA"/>
        <property type="gene ID" value="AEPI003320"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003320"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF16">
        <property type="entry name" value="BLACK MATCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003320-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9243" checksum="4F2C46B1238E17F6" modified="2016-09-07" version="1">MECSIFVFEKRTAEKLHKPKRKETVTEILRASVKQLERFRHPKILQIMHTVEESSETLSFATEPVIASLANILAYQVSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8T9</accession>
    <name>A0A182P8T9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8T9"/>
    <dbReference type="STRING" id="199890.A0A182P8T9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003343-RA">
        <property type="protein sequence ID" value="AEPI003343-PA"/>
        <property type="gene ID" value="AEPI003343"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003343"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15619">
        <property type="entry name" value="PHD1_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15530">
        <property type="entry name" value="PHD2_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000005">
        <property type="entry name" value="zinc finger protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025750">
        <property type="entry name" value="DPF1-3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF5">
        <property type="entry name" value="D4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14051">
        <property type="entry name" value="DPF1-3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="419"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="476"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003343-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="531" mass="55735" checksum="F268BBD3282E87CC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P943</accession>
    <name>A0A182P943_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P943"/>
    <dbReference type="STRING" id="199890.A0A182P943"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003447-RA">
        <property type="protein sequence ID" value="AEPI003447-PA"/>
        <property type="gene ID" value="AEPI003447"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003447"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003447-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="162" mass="18211" checksum="C51183D961F6BA36" modified="2016-09-07" version="1">MEKERFLEKCIRPVTLPMVSQNGTPPMAMPMQVPHGHMMQQIVDENGTLRHVILSTQPPQPLRQGNVQHHLHPSAFPIHARWRLRGVWSNGIADLLLICGTFTKLLGPADRSVAEQTAHMERGMTFGIGRVPNMFRHRCVKGMGLQNSNRGAPFCTNRVGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9S1</accession>
    <name>A0A182P9S1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9S1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003675-RA">
        <property type="protein sequence ID" value="AEPI003675-PA"/>
        <property type="gene ID" value="AEPI003675"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003675"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005398">
        <property type="entry name" value="Tubby_N"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01574">
        <property type="entry name" value="TUBBYPROTEIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="133"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003675-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="209" mass="20860" checksum="E6784311A262EEDF" modified="2016-09-07" version="1">MNRFYVYELIVEKLRYAEIGDDLDFAFVDLIPGIDPIWTERRPKPKTPPPPPKLPTPPPPPPAPKEEAGAAAAGGEGEAAAAAGEGAPAGPVKARTPSPFELRKHFPPEAAEVPYVRSSTGTTPKTSPAKEVAAAPAEATPAPEAAPAEAPAEGAADAAAAPPAEAAAPAPEGEAAPAPAEEAAPAAEAAPAPEAPPAEPAPEAEAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA53</accession>
    <name>A0A182PA53_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">ADAM 17-like protease</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PA53"/>
    <dbReference type="STRING" id="199890.A0A182PA53"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003807-RA">
        <property type="protein sequence ID" value="AEPI003807-PA"/>
        <property type="gene ID" value="AEPI003807"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003807"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14246">
        <property type="entry name" value="ADAM17_MPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04270">
        <property type="entry name" value="ZnMc_TACE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000017">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034025">
        <property type="entry name" value="ADAM10_ADAM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032029">
        <property type="entry name" value="ADAM17_MPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF6">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16698">
        <property type="entry name" value="ADAM17_MPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131020" description="ADAM 17-like protease" evidence="16">
        <location>
            <begin position="20"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="689"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="18">
        <location>
            <begin position="249"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="17">
        <location>
            <begin position="494"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="186"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003807-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="86040" checksum="D9D05E2C89239480" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAH3</accession>
    <name>A0A182PAH3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAH3"/>
    <dbReference type="STRING" id="199890.A0A182PAH3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003927-RA">
        <property type="protein sequence ID" value="AEPI003927-PA"/>
        <property type="gene ID" value="AEPI003927"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003927"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="83"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="176"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003927-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="442" mass="48923" checksum="0D81AD4470F087BC" modified="2016-09-07" version="1">MSTSVSAGAEKADNLPARKRQNRQTVLAMLKKADIKNKGLKRFFYFTYDAEPSSAKQEQVKKLYFSNGEICEGDEYFLQHMKKSVFVSNIPGGTKKSEIYQLFQRFGMVLSIELRTRGGRTIVGRQSQYPFETGPYLCSTIEFDSSESAKNACEVKTESAFVAKPILNPSLLGTENCVYVENIPAATTRQELWQHFKIFGPIRSIRMEFPDGTLVLTDAEYAQLRSVNCHIRFRRRAEARAAAKGLNRSTFKERQISVQMAYQKYCNPDELSNNALRIFFQPFGDVVSLDQIAHQRAGYVCFKLPIPADIIKRANQQTFRHRRITIEKLELPGIPKEGKAINKTTIGNGKNKEREGTNPGNGSTSGANSISSGSASNSNRGGASGKVSTIQIKLGRKIARKGLPVGRKPLAKKVSSDVAKPETGKMGGKGASENAKENRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAV2</accession>
    <name>A0A182PAV2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAV2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004057-RA">
        <property type="protein sequence ID" value="AEPI004057-PA"/>
        <property type="gene ID" value="AEPI004057"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004057"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004057-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="136" mass="15467" checksum="CCC7D443B63A3134" modified="2016-09-07" version="1">MKELEGCGVNLFSSLMTRLQQQVEEYTACQQGANQADTNRNCSDSVRRATVDLQQQLDSYKECTKNIRLKPDSRTELIECSSVLFHLAAIRISQQFEEFLNCKQQSKGDCSDSIQRATDDLQQGLHNFIHCTKDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAV8</accession>
    <name>A0A182PAV8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RFXA_RFXANK_bdg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAV8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004063-RA">
        <property type="protein sequence ID" value="AEPI004063-PA"/>
        <property type="gene ID" value="AEPI004063"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004063"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.290.30">
        <property type="entry name" value="Regulatory factor X-associated C-terminal binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038308">
        <property type="entry name" value="RFXAP_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004063-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="79" mass="8755" checksum="4EB9FC6B375E88C2" modified="2016-09-07" version="1">MLLSPGAANSNDTTNSSINSTDQDGELNDRDTCDKGDKGTTKPNQRMDIFSMILNQKKSSLMRDPEVIRFMENLTGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB20</accession>
    <name>A0A182PB20_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 NT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EEIG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PB20"/>
    <dbReference type="STRING" id="199890.A0A182PB20"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004125-RA">
        <property type="protein sequence ID" value="AEPI004125-PA"/>
        <property type="gene ID" value="AEPI004125"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004125"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="370"/>
        </location>
    </feature>
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            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1130"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="804"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1130"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1143"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004125-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1241" mass="129309" checksum="23F0FFB4087A07D7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBP8</accession>
    <name>A0A182PBP8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase S1 family. CLIP subfamily.</text>
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    <dbReference type="STRING" id="199890.A0A182PBP8"/>
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        <property type="gene ID" value="AEPI004353"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004353"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF139">
        <property type="entry name" value="CLIP DOMAIN-CONTAINING SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131064" description="Peptidase S1 domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
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            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
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            <end position="569"/>
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            <end position="857"/>
        </location>
    </feature>
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        <location>
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            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
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            <end position="1430"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
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            <end position="1712"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="1757"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="2046"/>
            <end position="2305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004353-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2311" mass="260576" checksum="32A27D690F7B5AF1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC24</accession>
    <name>A0A182PC24_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PC24"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004480-RA">
        <property type="protein sequence ID" value="AEPI004480-PA"/>
        <property type="gene ID" value="AEPI004480"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004480"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029195">
        <property type="entry name" value="HCFC1R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16246">
        <property type="entry name" value="HOST CELL FACTOR C1 REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16246:SF2">
        <property type="entry name" value="HOST CELL FACTOR C1 REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004480-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="317" mass="35293" checksum="C4CB45D5148239A0" modified="2016-09-07" version="1">MASHSSFYQGTKRISPLKIRNPSILPSQIMPSPTGAPFNFGEMPWSYGMKPGQVMEFNAVIRPSPITGPPSPIPLMTSGSNPPSFGPAPVTFLPELRKRKPDPDVIPIPSKQFLTEEAMSSHFNNLHLSSEYTAHDIRTNSSTPEAPTHSGLEEDMLLGDTSNLLEDTNAYRVCMSPQELEERLKKAQRIAICEEVRRLDGRGEILPKALLERIEKPCTALMIWQPPQERVQSVLSKVAQQLEEREREDRKATKNSNNNNNNNSEAAVDSMAISDEPLPDLPEYDEDLGFELDASGTDWQRRSAPDAPDPATMDVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCD6</accession>
    <name>A0A182PCD6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PCD6"/>
    <dbReference type="STRING" id="199890.A0A182PCD6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004591-RA">
        <property type="protein sequence ID" value="AEPI004591-PA"/>
        <property type="gene ID" value="AEPI004591"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004591"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000075">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF883">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007950986" description="Metalloendopeptidase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="79"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004591-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="372" mass="40915" checksum="58CFC59445C86EAB" modified="2016-09-07" version="1">MLRGKETLFALGALLLACSMLEWAEGRCATGPSLEVGRRLRAMRARKASAAGRVPKPWEMGFGEYKEGDIMERAPRQRNGVALSVFPSARWPNAIVPYVIRNTFTASQRSTILSGMAQIAAATCVRFVARTSESIFLTIGNGESGCWSYVGRSTRNSENQVNLQSPDCVDIGTVVHELMHAIGFYHEFTRPDRDEYVSIDRTALRSEYQTNSFFEDNYGKMAANEVVLYGRPYDYGSVMHYSKYAAAASRTRPVMNNLKPWTGDFGNDNGLSAADIIDINYMYCNSTTTTTARAATTTTTTTTARPATTTTTTTARPVTTTTTTTRAATTTTTRAPATTVGPGIFTRVIRVPITRFLEILRTLPLFNLFSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCQ0</accession>
    <name>A0A182PCQ0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCQ0"/>
    <dbReference type="STRING" id="199890.A0A182PCQ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004705-RA">
        <property type="protein sequence ID" value="AEPI004705-PA"/>
        <property type="gene ID" value="AEPI004705"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004705"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF43">
        <property type="entry name" value="GEO07291P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131101" evidence="6">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004705-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="465" mass="53557" checksum="ADABA88F835FE4DA" modified="2016-09-07" version="1">MIITTVVLSALFHLSLQTSPPKALDPEQTLYVYKRCFEDHLPWSSSRATYIKSWTVWILEPNDPITHCYVRCALSGLQLYDEKAKSFKSEGIPVQYEAFKTLNGVDAKEVNEYRQAVSSISAGGGSCLEVYNAYIPVHNKFKNVARRLYHGTIDGAAKVYAAMPQTKKRGESFFAFCAKKVWGEDKKKWRKFRSYSLTDSAELKQVVDCVFRGLRYMDESGLKVGEVVRDFNLINKSDLEPEVRSASEPWKALDPEQALYVYKRCYEDHLPSGPSRPTYLKSWNAWKLEPNDPVTQCYAKCVLIGLQLYDENEKAFKIKQKGESYFAYCAKKVWGEDKKKWRKFRSYSLTDSAELKQVVDCVFRGLRYMDESGLKVGEVVRDFNLINKSDLEPEVRSVLASCKGTTAYDYYSCLLNSPVKEDFKKAFDFHELRSADYAFLLRGKVYEGPEKVKEEMKRLNTTVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCT2</accession>
    <name>A0A182PCT2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Apyrase</fullName>
            <ecNumber evidence="4">3.6.1.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.5" evidence="4"/>
    <dbReference type="STRING" id="199890.A0A182PCT2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004737-RA">
        <property type="protein sequence ID" value="AEPI004737-PA"/>
        <property type="gene ID" value="AEPI004737"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004737"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004050">
        <property type="term" value="F:apyrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000001">
        <property type="entry name" value="NT5E isoform 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF32">
        <property type="entry name" value="APYRASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0222">Digestion</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="13 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1201">Platelet aggregation inhibiting toxin</keyword>
    <keyword evidence="8 21" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14 21" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10 22" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="15" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131164" description="Apyrase" evidence="22">
        <location>
            <begin position="24"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="23">
        <location>
            <begin position="1093"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="23">
        <location>
            <begin position="1342"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="23">
        <location>
            <begin position="1562"/>
            <end position="1782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00074431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004737-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1785" mass="195057" checksum="46A91CC0CDCB61D5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCW3</accession>
    <name>A0A182PCW3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dystrobrevin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dystrophin family. Dystrobrevin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCW3"/>
    <dbReference type="STRING" id="199890.A0A182PCW3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004768-RA">
        <property type="protein sequence ID" value="AEPI004768-PA"/>
        <property type="gene ID" value="AEPI004768"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004768"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16244">
        <property type="entry name" value="EFh_DTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000014">
        <property type="entry name" value="Dystrobrevin alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017432">
        <property type="entry name" value="Distrobrevin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF27">
        <property type="entry name" value="DYSTROBREVIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038204">
        <property type="entry name" value="Distrobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="230"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004768-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="710" mass="78455" checksum="401F012874842141" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD03</accession>
    <name>A0A182PD03_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRELD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PD03"/>
    <dbReference type="STRING" id="199890.A0A182PD03"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004808-RA">
        <property type="protein sequence ID" value="AEPI004808-PA"/>
        <property type="gene ID" value="AEPI004808"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004808"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131106" description="EGF-like domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="158"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004808-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="386" mass="42441" checksum="C51872A59F42D920" modified="2016-09-07" version="1">MRQSFGIVICMLVALLPSLSLGDIPKPPSFSSGGGGTKKDKLKTEKLPPCKACTVFVNSFRDGIKRTERAKHDGGDAAWEEERLGSYKTSELRLVEIQERLCTDVVRGEDQCHQLAEEYETQIEEWWKNHQTTYPDLHRWLCVEQAAVCCPDGFYGPNCDPCPTCFGNGKCKGNGTRKGNGKCACDEGYTGDNCDSCGEEYYQAFRDETKLLCSRCHKACAAGGCTGAGPNSCRVCRSGWVMDTARGGCVDVDECIKEAPCSKQQFCVNNEGSYSCLECDKSCDGCNGDGPDLCEKCGNGYELRDGMCTDTSNERRNQYANFTRYLTYLGLCIATCIVLQNSTWLAALVGLAVAIYISVSEYWLNTAPQQPAAPSPRILDEILQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD35</accession>
    <name>A0A182PD35_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PD35"/>
    <dbReference type="STRING" id="199890.A0A182PD35"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004840-RA">
        <property type="protein sequence ID" value="AEPI004840-PA"/>
        <property type="gene ID" value="AEPI004840"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004840"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000149">
        <property type="entry name" value="Protein arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000003">
        <property type="entry name" value="Protein arginine N-methyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000008">
        <property type="entry name" value="Protein arginine N-methyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="27"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="277"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="447"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="311"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="398"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004840-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="622" mass="71831" checksum="2BB83D695A217D4E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDZ2</accession>
    <name>A0A182PDZ2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDZ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005147-RA">
        <property type="protein sequence ID" value="AEPI005147-PA"/>
        <property type="gene ID" value="AEPI005147"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005147"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005147-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="186" mass="21181" checksum="DC2620FB69855BD1" modified="2016-09-07" version="1">MCTRDYYRVFGYFLGFLWMASAVYYTTETIELLKLMRLRCDKTAGSLRAPPDGDGGTDGGGGLARLQFSTEMITRVCDFYTHLDVFLPYHIITTVIKMTPGVMLVIGIFKSNITLVQVFAVYGILEECYFVIVFSKIFAVIQAFNTTVWIYWIVVIFCIKLFFAIWILLGVYAAVQPSPRTRPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE42</accession>
    <name>A0A182PE42_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PE42"/>
    <dbReference type="STRING" id="199890.A0A182PE42"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005197-RA">
        <property type="protein sequence ID" value="AEPI005197-PA"/>
        <property type="gene ID" value="AEPI005197"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005197"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="216"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005197-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="438" mass="49118" checksum="F0B076831DACF488" modified="2016-09-07" version="1">MGQNQSAGSGGDKDKDKDKKKKYEPPIPTRVGKKKRKAKGPDAALKLPQVTPHTRCRLKLLKLERIKDYLLMEEEFIRNQERLKPQEEKIEEERSKVDDLRGSPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLEPGCSVLLNHKVHAVVGVLGDDTDPMVTVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKRRIFNIHTARMTLAEDVNLSELIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKESVLYRKKEGTPEGLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE76</accession>
    <name>A0A182PE76_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PE76"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005231-RA">
        <property type="protein sequence ID" value="AEPI005231-PA"/>
        <property type="gene ID" value="AEPI005231"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005231"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF147">
        <property type="entry name" value="EG:BACR7A4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="266"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="615"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="873"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="1158"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="1456"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="1961"/>
            <end position="2177"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="2245"/>
            <end position="2489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005231-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2489" mass="280066" checksum="7851EC182825A958" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEB1</accession>
    <name>A0A182PEB1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEB1"/>
    <dbReference type="STRING" id="199890.A0A182PEB1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005266-RA">
        <property type="protein sequence ID" value="AEPI005266-PA"/>
        <property type="gene ID" value="AEPI005266"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005266"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005266-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="742" mass="79229" checksum="EC07DE05FA5B01FC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEJ1</accession>
    <name>A0A182PEJ1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEJ1"/>
    <dbReference type="STRING" id="199890.A0A182PEJ1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005346-RA">
        <property type="protein sequence ID" value="AEPI005346-PA"/>
        <property type="gene ID" value="AEPI005346"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005346"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:microfilament motor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:actin filament organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:determination of left/right symmetry"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:imaginal disc-derived male genitalia morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007498">
        <property type="term" value="P:mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000004">
        <property type="entry name" value="Unconventional myosin ID"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF679">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 10" id="KW-0518">Myosin</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="12"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="12">
        <location>
            <begin position="828"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="10">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005346-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1014" mass="117192" checksum="4A4DB024D6BFB179" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEQ2</accession>
    <name>A0A182PEQ2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEQ2"/>
    <dbReference type="STRING" id="199890.A0A182PEQ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005407-RA">
        <property type="protein sequence ID" value="AEPI005407-PA"/>
        <property type="gene ID" value="AEPI005407"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005407"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF21">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005407-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="710" mass="80257" checksum="FA7A900B7E128ECB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF34</accession>
    <name>A0A182PF34_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PF34"/>
    <dbReference type="STRING" id="199890.A0A182PF34"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005539-RA">
        <property type="protein sequence ID" value="AEPI005539-PA"/>
        <property type="gene ID" value="AEPI005539"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005539"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005539-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13224" checksum="701B7689F4B6A3ED" modified="2016-09-07" version="1">MAGSAVGSATIFTKEPTVRIQCQSGSMLITIKDAPANLNGQFSGMVYPKGLAKNSTCLTEYHEQEGPLRYKLPLKSCNTMPLETVSFHSLFWAVGVQESSTTTHAQRATSWDGTDDEAFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFI3</accession>
    <name>A0A182PFI3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PFI3"/>
    <dbReference type="STRING" id="199890.A0A182PFI3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005690-RA">
        <property type="protein sequence ID" value="AEPI005690-PA"/>
        <property type="gene ID" value="AEPI005690"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005690"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052596">
        <property type="entry name" value="AMBRA1_autophagy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874:SF1">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005690-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="583" mass="66440" checksum="91D29F1B46052B2A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFQ0</accession>
    <name>A0A182PFQ0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Gtpase-activating protein centaurin gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centaurin gamma-like family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PFQ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005757-RA">
        <property type="protein sequence ID" value="AEPI005757-PA"/>
        <property type="gene ID" value="AEPI005757"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005757"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08836">
        <property type="entry name" value="ArfGap_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01250">
        <property type="entry name" value="PH_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000001">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000109">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000258">
        <property type="entry name" value="centaurin-gamma-1A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000025">
        <property type="entry name" value="luciferin 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819:SF5">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="340"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="10">
        <location>
            <begin position="593"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005757-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1404" mass="152245" checksum="5F4DAD8DF4731CF6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGG4</accession>
    <name>A0A182PGG4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CDT1 Geminin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGG4"/>
    <dbReference type="STRING" id="199890.A0A182PGG4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006023-RA">
        <property type="protein sequence ID" value="AEPI006023-PA"/>
        <property type="gene ID" value="AEPI006023"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006023"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071163">
        <property type="term" value="P:DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08767">
        <property type="entry name" value="Cdt1_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08674">
        <property type="entry name" value="Cdt1_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045173">
        <property type="entry name" value="Cdt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014939">
        <property type="entry name" value="CDT1_Gemini-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28637">
        <property type="entry name" value="DNA REPLICATION FACTOR CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28637:SF1">
        <property type="entry name" value="DNA REPLICATION FACTOR CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08839">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01075">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDT1 Geminin-binding" evidence="4">
        <location>
            <begin position="355"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006023-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="751" mass="83801" checksum="809A6626E959F907" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGH6</accession>
    <name>A0A182PGH6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGH6"/>
    <dbReference type="STRING" id="199890.A0A182PGH6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006035-RA">
        <property type="protein sequence ID" value="AEPI006035-PA"/>
        <property type="gene ID" value="AEPI006035"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006035"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.840:FF:000003">
        <property type="entry name" value="Kurtz arrestin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017864">
        <property type="entry name" value="Arrestin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF17">
        <property type="entry name" value="KURTZ ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00295">
        <property type="entry name" value="ARRESTINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="217"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006035-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="503" mass="55602" checksum="92C0291F8D5129C0" modified="2016-09-07" version="1">MNTHLQGSSPRSPAPSPDPDVDEGSSKKQATRVFKKSSSNGKITVYLGKRDFVDHITHVDPIDGVVLIDPDYVKERKVFGHVLAAFRYGREDLDVLGLTFRKDLYLASEQIYPPLETDRPLTRLQERLIRKLGANAYPFYFEVPPHCPASVSLQPAPGDTGKPCGVDYELKAFVGESQEDKPHKRNSVRLAIRKIMYAPSKLGEQPSIEVSKEYILKPNKIHLEASLDKELYHHGESLSVNVHIANNSSKTVKKIKVSVRQFADICLFSTAQYKCTVAEVESEEYTVGPGFTLSKVFTIKPLLKHNKHKRGLALDGQLKHEDTNLASSTMDGCQVAPGFTLSKVFTLTPLLANNKDKWGLALDGQLKHEDTNLASSTLIADPSQRENLGIIVQYKVKVKLCITPLGGDLVAELPFILMHPKPDDDEPVIGDRSPGRTVNSADRKHSYQAGHEMGSHSNNGDAHASKEDGPNLIQLDGDDNGPDDDIIFEDFARLRLKGAETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGK3</accession>
    <name>A0A182PGK3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGK3"/>
    <dbReference type="STRING" id="199890.A0A182PGK3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006062-RA">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MYOGENIC-DETERMINATION PROTEIN"/>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="185"/>
            <end position="236"/>
        </location>
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        <location>
            <begin position="248"/>
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        </location>
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        <location>
            <begin position="253"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006062-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="268" mass="28379" checksum="66FE54392C46CEAD" modified="2016-09-07" version="1">MTKFNRTGGRKSAIKSELTGCFKQGYEVDHRSFGELMPAGTGNGTIMASSAMHGKANGNSCGASVNGGLQQKSVLSLPAGMVGGTGSANLIGGGSCNVTNGAGGAGSGSGNGGYLHDLSAEQKLKLNIQQLHIRQKQLQLTDYDDTSLSSEEHVLAPAAGCMASPNRPCLTWACKACKKKSVAVDRRKAATLRERRRLRKVNEAFEVLKRRTSTNPNQRLPKVEILRNAIEYIDSLQALLDETPPIHQGSDILSNGSGTGLSTSQDYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGP9</accession>
    <name>A0A182PGP9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGP9"/>
    <dbReference type="STRING" id="199890.A0A182PGP9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006108-RA">
        <property type="protein sequence ID" value="AEPI006108-PA"/>
        <property type="gene ID" value="AEPI006108"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006108"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40240">
        <property type="entry name" value="PLEXUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40240:SF1">
        <property type="entry name" value="PLEXUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
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        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
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        <location>
            <begin position="623"/>
            <end position="704"/>
        </location>
    </feature>
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        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
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        <location>
            <begin position="790"/>
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        </location>
    </feature>
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        <location>
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            <end position="829"/>
        </location>
    </feature>
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        <location>
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            <end position="885"/>
        </location>
    </feature>
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        <location>
            <begin position="906"/>
            <end position="918"/>
        </location>
    </feature>
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        <location>
            <begin position="929"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="981"/>
        </location>
    </feature>
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        <location>
            <begin position="982"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006108-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1193" mass="121617" checksum="15CF657B63C97EA6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGQ9</accession>
    <name>A0A182PGQ9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGQ9"/>
    <dbReference type="STRING" id="199890.A0A182PGQ9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006118-RA">
        <property type="protein sequence ID" value="AEPI006118-PA"/>
        <property type="gene ID" value="AEPI006118"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006118"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15390">
        <property type="entry name" value="7tmA_TACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00244">
        <property type="entry name" value="NEUROKININR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="103"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006118-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="455" mass="51360" checksum="C4F6E35A670D3D99" modified="2016-09-07" version="1">MELELALALLTGGNKSTTTGTSCCPSGSGNGSELGWSATSADLLEIGWRESSPPTFSSSAPYPEPNATAESIQIMDFFSILPLWRLIVWNVLFAGIVITATVGNLIVVWIVLSHKRMRTVTNYFLVNLSIADAMVSTLNVTFSYTYMLYLDWPFGTTYCKISQFVAVLSICASVFTLMAIAIDRYVAIMNPLKPRMGKKATLCVAASIWIIGTIISCPSLLFFTTYPLKDHILCYAEWPDGPSNHSHQEYVYNIVFMLLTYFLPIGSMTYTYARVGLELWGSKSIGECTQRQLDNIKSKRRVVKMMMIVVIIFAVCWLPFQIYFILTSYYPDLTKKPYIQEVYLAIYWLAMSNSMYNPIIYCWMNSRFRRGFQQFFRCCPFVRVTPDSASSHRRTDTERSFLYNGSQSPTGQRKWQTGPMRRVNTILTSQLNQTTSLCCAAQDAPLATGPGRTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGU9</accession>
    <name>A0A182PGU9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">40S ribosomal protein S23</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the 40S small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGU9"/>
    <dbReference type="STRING" id="199890.A0A182PGU9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006158-RA">
        <property type="protein sequence ID" value="AEPI006158-PA"/>
        <property type="gene ID" value="AEPI006158"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006158"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006158-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="143" mass="16119" checksum="130F4F62C8EDC7F6" modified="2017-10-25" version="2">MGKPRGIRTARKHIRHRRDQRWADKDYKKAHLGTRWKSNPFAGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPRDGCLNYIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKEKKERPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH17</accession>
    <name>A0A182PH17_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PH17"/>
    <dbReference type="STRING" id="199890.A0A182PH17"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006226-RA">
        <property type="protein sequence ID" value="AEPI006226-PA"/>
        <property type="gene ID" value="AEPI006226"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006226"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF130">
        <property type="entry name" value="PATCHED DOMAIN-CONTAINING PROTEIN 3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="809"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="848"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="894"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="930"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="4">
        <location>
            <begin position="380"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006226-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1002" mass="112411" checksum="104D861CEE517417" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHH4</accession>
    <name>A0A182PHH4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHH4"/>
    <dbReference type="STRING" id="199890.A0A182PHH4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006383-RA">
        <property type="protein sequence ID" value="AEPI006383-PA"/>
        <property type="gene ID" value="AEPI006383"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006383"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13160">
        <property type="entry name" value="PTB_LDLRAP_insect-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF57">
        <property type="entry name" value="RE46159P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006383-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24628" checksum="568F7338BA99B8F6" modified="2019-01-16" version="2">MSTKLSNGSSVGGINTAPNNTSLSANNNNNNNNDSPDVQVTVKDLPISFKVKYLGSQPATGLWGIKHTRLPVDHLVSVAKNLPPNRILPFCNLTVSLDGVKIESITSKLTSVSNFTIDTISYGVQDLVYTRVFAMIVVKENYNLKEKNPFDVHAFVCDSRAMARKLTFALAASFQDYSKRVKEAEEKNGGSGGDPEKSLRKKFAIDLRTPEEMQQDITEQETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJH8</accession>
    <name>A0A182PJH8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJH8"/>
    <dbReference type="STRING" id="199890.A0A182PJH8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007092-RA">
        <property type="protein sequence ID" value="AEPI007092-PA"/>
        <property type="gene ID" value="AEPI007092"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007092"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013153453" evidence="4">
        <location>
            <begin position="16"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007092-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="389" mass="35318" checksum="DA5E1BC24D9EA66C" modified="2016-09-07" version="1">MKVFLLATLVAACSCARLDNNYLPPPGAAAAGGGPGLTAPSPGGGSRPGGAPGGPGGFGGPGTAPGSGGFGGGAPSGSGFGGAGPSAGGFGGQGQRPGGVGGGPAAGRPGTPAPAYGPPSSGFGGGAPSAFGGGAGAPSGGFSSGGSGFGGGAPGAAPAGPSQPPIEIISYENMNNGDGTYKYSYETANGIKVQEQGEIKNKGSENEIPSVQGSYSYTAPDGQVITVTYIADENGFQPQGDHLPTPPPIPAEIQKGLDAIAAAQAAGGSAGGPGGPSGAGGYPGAGGAGGKPSQGYPGSVTGSGGYPSGAGGPGASGPGAVGRPGQGQGYPSGPAGGSAGYPAAGGPGAPGGSAGYPSGGPGAPAAPRPSAPGRPSGNGSFNPQSGYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJS3</accession>
    <name>A0A182PJS3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJS3"/>
    <dbReference type="STRING" id="199890.A0A182PJS3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007188-RA">
        <property type="protein sequence ID" value="AEPI007188-PA"/>
        <property type="gene ID" value="AEPI007188"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007188"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131494" description="CUB domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007188-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11854" checksum="C1C5FF5A46C6BC3A" modified="2016-09-07" version="1">MIMKAIHYSLLAALALKLLGVCYGCKISEYPCKGGASCVPLDKYCDGRDDCGDGSDEPKLCTVCNRTYYGDIGRTYTLTVPPPQWNRLPFLCHLTFTASGHEQGDIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJV7</accession>
    <name>A0A182PJV7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJV7"/>
    <dbReference type="STRING" id="199890.A0A182PJV7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007223-RA">
        <property type="protein sequence ID" value="AEPI007223-PA"/>
        <property type="gene ID" value="AEPI007223"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007223"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09430">
        <property type="entry name" value="LIM5_LIMPETin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000013">
        <property type="entry name" value="Four and a half LIM domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000070">
        <property type="entry name" value="Four and a half LIM domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF4">
        <property type="entry name" value="PROTEIN ESPINAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="53"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="115"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007223-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="174" mass="20045" checksum="4352276057992641" modified="2016-09-07" version="1">MTTCTKKMEYKTRQWHEKCFCCCVCKTAIGTKSFIPREQEIYCAGCYEEKYATRCIKCKKIITSGGVTYKNEPWHRECFTCTHCQVSLAGQRFTSRDEKPYCAECFGELFAKRCTSCTKPITGIGGTRFISFEDRHWHNDCFICAMCKTSLVGRGFITDEQDVICPECAKQKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKA7</accession>
    <name>A0A182PKA7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gonadal protein gdl</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gonadal family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKA7"/>
    <dbReference type="STRING" id="199890.A0A182PKA7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007373-RA">
        <property type="protein sequence ID" value="AEPI007373-PA"/>
        <property type="gene ID" value="AEPI007373"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007373"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010849">
        <property type="entry name" value="Gonadal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054">
        <property type="entry name" value="DIGEORGE SYNDROME CRITICAL REGION 6 DGCR6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054:SF2">
        <property type="entry name" value="PROTEIN DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07324">
        <property type="entry name" value="DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007373-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22669" checksum="07EC59C40033A2BC" modified="2016-09-07" version="1">MENTKNIETSAKLSDDAIADPFSNQEYLQRKLYFLLEHLKKMHGDLPEQYQMRISYDLLAGLANSLLNDTIFEIVKGLMEIQHVTEAHLMQVREKVENDHQLELKQWESKIQDPEELEHIVALMKIKHGKNMKETDMKLVLHLDQKVKDQQSTLEKAGVPGFYVTDNQKEINIQMYLLDFILRLSRIKFESNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKX2</accession>
    <name>A0A182PKX2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKX2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007589-RA">
        <property type="protein sequence ID" value="AEPI007589-PA"/>
        <property type="gene ID" value="AEPI007589"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007589"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007589-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="382" mass="44318" checksum="D3E2F36BAC881D15" modified="2016-09-07" version="1">MQKLQAPKRAGKIPPTRDPHLETLINELERKLRKPTASDPIDLDMTHIIPRRLYDRLKRMVQLPPYDDREFEGILAARLQDPPGMHDSDWRSTDDDDNDGETDVRTESGTMADRREQPPFELMVEERSAARSRVIPTDTESNWMEAYLRKTGNERIQWQTKYYRTDQKLLDKPLFQQIEELIDLGAQDFSEWLSGLGAEKSNITKDIIKQLFSIEIEDEMARALRVDTREIRAIPTDAARHWNLDQMALQNRIAQVMRADRKAMANVRTKNVAFGRTLPPALRTTSRTDSTDTIEPDFPDDLRTMRALFQDIRHLRSVRYLIDHLRTRPDIQRPRYLLDAGLFRSGTGARSAPFYQQVLPRKVILDSVRHKQSPPHAGHLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKX5</accession>
    <name>A0A182PKX5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Otopetrin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKX5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007592-RA">
        <property type="protein sequence ID" value="AEPI007592-PA"/>
        <property type="gene ID" value="AEPI007592"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007592"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF30">
        <property type="entry name" value="GH01206P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007592-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="88378" checksum="0222B8DE915AE9B3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL38</accession>
    <name>A0A182PL38_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">InsP6 and PP-IP5 kinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3"/>
    <dbReference type="STRING" id="199890.A0A182PL38"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007655-RA">
        <property type="protein sequence ID" value="AEPI007655-PA"/>
        <property type="gene ID" value="AEPI007655"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007655"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="15">
        <location>
            <begin position="142"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
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            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
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            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1018"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1137"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1308"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1930"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2092"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2135"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2185"/>
            <end position="2263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1142"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1190"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1202"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1260"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1759"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1776"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1792"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1950"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1985"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="2149"/>
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        </location>
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        <location>
            <begin position="2196"/>
            <end position="2210"/>
        </location>
    </feature>
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            <end position="2233"/>
        </location>
    </feature>
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        <location>
            <begin position="2234"/>
            <end position="2245"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007655-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2263" mass="249824" checksum="E951B2D7497F4ECB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLH1</accession>
    <name>A0A182PLH1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Wolframin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLH1"/>
    <dbReference type="STRING" id="199890.A0A182PLH1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007791-RA">
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        <property type="gene ID" value="AEPI007791"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007791"/>
    <dbReference type="Proteomes" id="UP000075885">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Wolframin_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045460">
        <property type="entry name" value="Wolframin_EF-hand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026209">
        <property type="entry name" value="Wolframin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045461">
        <property type="entry name" value="Wolframin_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045458">
        <property type="entry name" value="Wolframin_Sel1-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13098">
        <property type="entry name" value="WOLFRAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13098:SF3">
        <property type="entry name" value="WOLFRAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WCOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19914">
        <property type="entry name" value="WEF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20023">
        <property type="entry name" value="WSLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02060">
        <property type="entry name" value="WOLFFAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Wolframin EF-hand" evidence="4">
        <location>
            <begin position="120"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Wolframin cysteine-rich" evidence="5">
        <location>
            <begin position="653"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Wolframin OB-fold" evidence="3">
        <location>
            <begin position="760"/>
            <end position="912"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007791-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="912" mass="102967" checksum="58B6E5ADDDC3A535" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLN0</accession>
    <name>A0A182PLN0_9DIPT</name>
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        <recommendedName>
            <fullName evidence="4">U3 small nucleolar RNA-associated protein 25 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UTP25 small subunit processor component</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLN0"/>
    <dbReference type="STRING" id="199890.A0A182PLN0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007850-RA">
        <property type="protein sequence ID" value="AEPI007850-PA"/>
        <property type="gene ID" value="AEPI007850"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007850"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="8">
        <location>
            <begin position="332"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="7">
        <location>
            <begin position="628"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007850-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="821" mass="94661" checksum="34A202113CCE8CCD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLV0</accession>
    <name>A0A182PLV0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLV0"/>
    <dbReference type="STRING" id="199890.A0A182PLV0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007922-RA">
        <property type="protein sequence ID" value="AEPI007922-PA"/>
        <property type="gene ID" value="AEPI007922"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007922"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF362">
        <property type="entry name" value="G PROTEIN ALPHA O SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="21"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="46"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="115"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007922-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="199" mass="23022" checksum="8CBD89C668CDFAE6" modified="2016-09-07" version="1">FLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKNLNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWFTDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAAAYIQAQFEAKNKSTSKEIYCHMTCATDTNNIQFVFDAVTDVIIANNLRGCGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM24</accession>
    <name>A0A182PM24_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PM24"/>
    <dbReference type="STRING" id="199890.A0A182PM24"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007996-RA">
        <property type="protein sequence ID" value="AEPI007996-PA"/>
        <property type="gene ID" value="AEPI007996"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007996"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070935">
        <property type="term" value="P:3'-UTR-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12412">
        <property type="entry name" value="RRM_DAZL_BOULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000167">
        <property type="entry name" value="protein boule-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034988">
        <property type="entry name" value="DAZ_BOULE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176">
        <property type="entry name" value="BOULE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176:SF57">
        <property type="entry name" value="PROTEIN BOULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007996-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="166" mass="17988" checksum="BF9D65357B019E83" modified="2016-09-07" version="1">MSIPTPAGQLDGATLAAPKYGTLIPNRVFVGGISGDTTEAELCRLFSSYGNVKSTKIIVDRAGVSKGYGFVTFETEHEAQKLQNDCDCIVLRDRKLNIAPAIKKQTLCATNGAVYYAATPPTPAINNIPIEQFATVYPPGVPTMYPPTLPYQPFYQYYSVPMEAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM77</accession>
    <name>A0A182PM77_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WAPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PM77"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008050-RA">
        <property type="protein sequence ID" value="AEPI008050-PA"/>
        <property type="gene ID" value="AEPI008050"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008050"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000374">
        <property type="entry name" value="Protein wings apart-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012502">
        <property type="entry name" value="WAPL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51271">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAPL" evidence="3">
        <location>
            <begin position="1290"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="493"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="579"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="659"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="783"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="807"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="901"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="942"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008050-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1831" mass="195921" checksum="D03602D875B89944" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMC8</accession>
    <name>A0A182PMC8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PMC8"/>
    <dbReference type="STRING" id="199890.A0A182PMC8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008101-RA">
        <property type="protein sequence ID" value="AEPI008101-PA"/>
        <property type="gene ID" value="AEPI008101"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008101"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008101-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="484" mass="54041" checksum="C5BD485851BE9F74" modified="2016-09-07" version="1">MSERFATIAEQLAKWQQSHLLKFWDELTESQRTALLESLSDSVDCASLDEAFRRAMATATSTKEDLNDLLKPLARERYLSVAEATETELEDLRQVGLEQVREGRVGVILLAGGQGTRLGSTAPKGTYNVNLPSGKSLFQLQAERIRKLQQLAGGEGRIRWYIMTSEHTHTETLEYFKQHQYFGLPADQVRMFRQRSVPCVDFEGRILLDEKWKVATAPDGNGGIYRALKDEGILDELEREGVLYLHAHSVDNILIKVADPVFVGYCVRKGADCGVKVIEKVQPDEAVGVVCEVKGKYQVVEYSELSSETANRRNPSDGKLTFNAGNICNHFFTTEFLRRIAETTMPLHVAKKKIPYVEVATGERLKPTAPNGIKMEKFIFDVFPLAERFVALEGRREEEFSALKNADTAGIDCPSSVRGDIYRLHRKWLIKAGAAEVLDAADASFDCEISPLLSYAGEGLETAATGQSFRCPVHLTGADEREQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMY0</accession>
    <name>A0A182PMY0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PMY0"/>
    <dbReference type="STRING" id="199890.A0A182PMY0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008304-RA">
        <property type="protein sequence ID" value="AEPI008304-PA"/>
        <property type="gene ID" value="AEPI008304"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008304"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DUF4806" evidence="5">
        <location>
            <begin position="34"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="331"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008304-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46629" checksum="6AF8D881050AC0E2" modified="2016-09-07" version="1">MDAEEAAITSTLVNLKREEDESTAKSTLLSSYEVQFPVEDEEGVELLESMVQLSANVRREYVDFLRSVGKSKMGIISVFCKIFSDKAMYPYNYSGMCNRGPRRKPMLKYDIFTHCMLVPLFNLMEPAIKIEEDSTDFGEFAFLSEQHLMEDITDSIKKGNNATSKRGISRKRKLDIAELFQLSSNITTSSTTIGQRNLLDKPFPICTINELNEFDALLLGNLSFTEKCAQMLHSVIRDEGNSLDNVTCHMRLLLEHAIDYTVILRYSWYGFMPRSPAARSSGEQHPFRNLLGVISLLHRARQLRFATCSREEINEGIEKFLKRKLRCHALKGKELLILNGHIYRVNRRRGRLRYWECASRRSKIRCPSKITTEYNTLRIISGGSHNHPSVNIHALEDDLSGDVLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNF2</accession>
    <name>A0A182PNF2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PNF2"/>
    <dbReference type="STRING" id="199890.A0A182PNF2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008479-RA">
        <property type="protein sequence ID" value="AEPI008479-PA"/>
        <property type="gene ID" value="AEPI008479"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008479"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16574">
        <property type="entry name" value="RING-HC_Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058746">
        <property type="entry name" value="Znf_RING-type_Topors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="568"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="792"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="905"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1012"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="602"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="758"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="803"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="912"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1045"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008479-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1061" mass="115091" checksum="B15889E0213BFFF1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNX6</accession>
    <name>A0A182PNX6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNX6"/>
    <dbReference type="STRING" id="199890.A0A182PNX6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008655-RA">
        <property type="protein sequence ID" value="AEPI008655-PA"/>
        <property type="gene ID" value="AEPI008655"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008655"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131669" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="82"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008655-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="153" mass="16886" checksum="DBED335DE91A877E" modified="2016-09-07" version="1">MLFTKANITAVLLLLTVYSGAALALPKIEDNLPQVKENPVPASSALKDDQVKTMVPQPRYLLPANFGVKIKKFSIGTLGVGSFFRAWRNCIQEGKGLATIESKQEQEYLESMLESISAGTRYWIGATNLGSSSKRKLTWITTDLPVERRANLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP03</accession>
    <name>A0A182PP03_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BolA-like protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP03"/>
    <dbReference type="STRING" id="199890.A0A182PP03"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008682-RA">
        <property type="protein sequence ID" value="AEPI008682-PA"/>
        <property type="gene ID" value="AEPI008682"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008682"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008682-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8839" checksum="9C0413DC0D6EBBA2" modified="2016-09-07" version="1">MAKNSEATLRKSLETKFPQAKNIVVTDISGGCGSMYEIFVESKEFKGLSTVKQHRLITETLKSEIKDMHGLRIHTSIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPM4</accession>
    <name>A0A182PPM4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H2 subunit B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPM4"/>
    <dbReference type="STRING" id="199890.A0A182PPM4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008903-RA">
        <property type="protein sequence ID" value="AEPI008903-PA"/>
        <property type="gene ID" value="AEPI008903"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008903"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.120:FF:000002">
        <property type="entry name" value="Ribonuclease H2 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.530:FF:000005">
        <property type="entry name" value="ribonuclease H2 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="10">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="9">
        <location>
            <begin position="84"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008903-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="284" mass="31570" checksum="367C71E3E6D8B705" modified="2016-09-07" version="1">MSANKFFFVFRDSLLKSDDAGLSIVSLRNPATRNASKYLIRRTAKACTLYEVNCFNEQHRSWFINESVCSNGKIFLPTPIDPLFLVLPYLVEHCSERAVPLDQILIDEKFPSISILAEALPSARLALIADEKRASSILAYKYNETKTLEWLVGKCHRLGKVLGKQDGPAAQSLNYIKEEKENETDEDEKGTLHTALGIVGDYLSLEFGRKLSVALGFPEDENISKKRKSAIDLESATVKRIKKEESHDTTPIKQPAGEKKVSAKAKALAKAASGSKSISSFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPT2</accession>
    <name>A0A182PPT2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPT2"/>
    <dbReference type="STRING" id="199890.A0A182PPT2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008962-RA">
        <property type="protein sequence ID" value="AEPI008962-PA"/>
        <property type="gene ID" value="AEPI008962"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008962"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF147">
        <property type="entry name" value="EG:BACR7A4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131629" description="Peptidase S1 domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="96"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008962-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="202" mass="22671" checksum="233A0F24646CFBB4" modified="2016-09-07" version="1">MLERGTLTLLGLLLVIVSPADRWAVLAFRKSFEELSVHTLPDSGSLEDCSLRLQKLAHDEPPAAPLEEFPSFSRDFAHLAALGWKAKSSDEIEWRCSGSLIAENFVLTAAHCTQDEGVEPTVVRLGDLDLYSPKDDRYAQQVEIEEIIRHPEFNFSSAYHDIALLRLKKSVTVTDFVTPACLYTNDSLTFDKLHATGWDFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQA5</accession>
    <name>A0A182PQA5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="16">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQA5"/>
    <dbReference type="STRING" id="199890.A0A182PQA5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009135-RA">
        <property type="protein sequence ID" value="AEPI009135-PA"/>
        <property type="gene ID" value="AEPI009135"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009135"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11 16" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="17">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS00300"/>
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    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009135-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="504" mass="55742" checksum="818D8B36634F9F49" modified="2016-09-07" version="1">MVLADLGRKITNALHSLSKATIINEEVLDSMLKEICTALLEADVNIRLVKKLRENVRSVIDFDEMAGGLNKRRMIQSAVFKELVKLVDPGVKPYQPIKGRPNVIMFVGLQGSGKTTTCTKLAYHYQKKNWKSCLVCADTFRAGAYDQIKQNATKARIPFYGSYTEVDPVTIAQDGVEMFKKEGFEFIIVDTSGRHKQEESLFEEMLAVANAVNPDNIIFVMDATIGQACEAQAKAFKEKVDIGSVIITKLDGHAKGGGALSAVAATNSPIIFIGTGEHIDDLEPFKTKPFISKLLGMGDIEGLIDKVNELKLDDNEELIDKIKHGQFTIRDMYEQFQNIMKMGPFSQIMGMIPGFSQDFMTKGGEQESMARIKRLMTMMDSMSDGELDNKDGAKLFSKQPTRVTRVAQGSGVMEREVRDLISQYTKFAAVIKKMGGIKGLFKSGDMTKNVNPTQMAKLNQQMAKMIDPRMFQQMGGMNGLQNMMRQLQQGAGGLGNLMSGFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQC3</accession>
    <name>A0A182PQC3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PQC3"/>
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        <property type="protein sequence ID" value="AEPI009153-PA"/>
        <property type="gene ID" value="AEPI009153"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009153"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="820"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="874"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="906"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="965"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1297"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1351"/>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1383"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1412"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
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            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="660"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1067"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1105"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1079"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1105"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1129"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009153-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1467" mass="171342" checksum="C645067249BEF4C3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQR5</accession>
    <name>A0A182PQR5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="AlphaFoldDB" id="A0A182PQR5"/>
    <dbReference type="STRING" id="199890.A0A182PQR5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009296-RA">
        <property type="protein sequence ID" value="AEPI009296-PA"/>
        <property type="gene ID" value="AEPI009296"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009296"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000005">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0835">Urea cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009296-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="360" mass="39417" checksum="F6D9E2DC433DAE00" modified="2016-09-07" version="1">MLPRIALARLVSRTAGTSISSSYCTSSTDPSFATIKPKKINYERIGIVGVPFDKGQRKKGVGLGPKAIRDAGLIDHIQEISPKLNIKDYGDIQYEALNFQGRKVGNMKKLEHVASCSRNLSHQVTEVLDDDRLCITLGGDHAIAIGSIDGHLHHSKDVAVIWVDAHADLNTNSTSPSGNIHGMPVALLARELCDYWPYIPGMDWQEPIISIKNLAYIGLRSVDPYERAIIEKFGINAFGMREVEKYGIREVMRMALERIDPEGQRSLHVSYDIDSLDVLEAPSTGTSVRGGLTLREGIYIMEEAYGTGRLAAVDLVEVNPAIGTPEDVRRTVEAAIHLLVAACGHSRKGDIADTLDLIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQU9</accession>
    <name>A0A182PQU9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosol aminopeptidase</fullName>
            <ecNumber evidence="7">3.4.13.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinylglycine-S-conjugate dipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Leucine aminopeptidase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-cysteinylglycine + H2O = L-cysteine + glycine</text>
            <dbReference type="Rhea" id="RHEA:28783"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:28784"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>S-benzyl-L-cysteinylglycine + H2O = S-benzyl-L-cysteine + glycine</text>
            <dbReference type="Rhea" id="RHEA:62568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:145802"/>
            <dbReference type="ChEBI" id="CHEBI:145803"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:62569"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an S-substituted L-cysteinylglycine + H2O = an S-substituted L-cysteine + glycine</text>
            <dbReference type="Rhea" id="RHEA:60444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.13.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60445"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.23" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A182PQU9"/>
    <dbReference type="STRING" id="199890.A0A182PQU9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009330-RA">
        <property type="protein sequence ID" value="AEPI009330-PA"/>
        <property type="gene ID" value="AEPI009330"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009330"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF25">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M17 leucyl aminopeptidase N-terminal" evidence="16">
        <location>
            <begin position="45"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="15">
        <location>
            <begin position="213"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009330-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="552" mass="60726" checksum="449B1E9B99C7A3E8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQW8</accession>
    <name>A0A182PQW8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQW8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009349-RA">
        <property type="protein sequence ID" value="AEPI009349-PA"/>
        <property type="gene ID" value="AEPI009349"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009349"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009349-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="293" mass="29103" checksum="C63D4DF810DE4AB4" modified="2016-09-07" version="1">MAGESPPRRLSQIFDPLMSLSELQAQIQQQQHQLAHLKYSGGSGGGGNSSGCPTPPLTSHPQCALGGMPQMASSSSAQTFSSSSTLQHHHGGTGGVGGHPNGGAGYYNTTASSSTSLSSVSNQSTKLSSSSSTGSYIGGTLGSGGSGSGCGGGSGGGGGVGGGGGGTGLPVPPPHVLGRIMMGSRSTPNSPRLMSRRNGSGSKPPPVPQKPTAAYIANPSLVALDCDAPWPPLGNLGPDALSMVEGHHHLGGGGGGGGYLHHQPEVSKGIQNCKRKFHNYSGHNPCAIPMRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR47</accession>
    <name>A0A182PR47_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sorting nexin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PR47"/>
    <dbReference type="STRING" id="199890.A0A182PR47"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009428-RA">
        <property type="protein sequence ID" value="AEPI009428-PA"/>
        <property type="gene ID" value="AEPI009428"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009428"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13338">
        <property type="entry name" value="FERM-like_C_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01777">
        <property type="entry name" value="FERM_F1_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23070">
        <property type="entry name" value="PDZ_SNX27-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06886">
        <property type="entry name" value="PX_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000210">
        <property type="entry name" value="Putative Sorting nexin-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.60:FF:000003">
        <property type="entry name" value="Sorting nexin-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000061">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000003">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037827">
        <property type="entry name" value="SNX27_FERM-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037833">
        <property type="entry name" value="SNX27_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037835">
        <property type="entry name" value="SNX27_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF19">
        <property type="entry name" value="SORTING NEXIN-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="148"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="9">
        <location>
            <begin position="272"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009428-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="59284" checksum="133312EAE762158F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR50</accession>
    <name>A0A182PR50_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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            <position position="211"/>
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            <name>Zn(2+)</name>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1029" mass="116295" checksum="3EBB127CA4160A12" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRA6</accession>
    <name>A0A182PRA6_9DIPT</name>
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        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12881:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
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</entry>
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            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Haas B."/>
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                <person name="Gujja S."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Larimer J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="3">Epiroticus2</strain>
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    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="2">
        <location>
            <begin position="552"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009701-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="664" mass="73393" checksum="2C65C522C381C01A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSN0</accession>
    <name>A0A182PSN0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PSN0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009965-RA">
        <property type="protein sequence ID" value="AEPI009965-PA"/>
        <property type="gene ID" value="AEPI009965"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009965"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009965-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="329" mass="36488" checksum="B0B2AF467C758404" modified="2016-09-07" version="1">MGLQLARRRKARYTDTSYLIFQQLTKGDVLYAFPLVVGLIQRSPKKEGATSSRPSSPRARCDETVSDEALVIDSPEESFLGKQKKPNTYKAKDTRKPAGSGIPRRQSKIAEKRKNRRSLELKAVEEVPREEDDTKEQEEQDETKVQVCDISGRPGANSGPVLGDGQPRTISVISSDEPDSVQKDIQVAVDFHHRPNSEVEPFRSSVVLEPNNNDLRCKTANETDRRPVDSDVESVSTLTPSIGPGADGPRRSGEEVDKQQRMLAPGVQIRRKQYPYEPCYLVGSEFSDTSDFTDTASSVASDLDETEYARVELRKGAVNGHAIDKPITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTN8</accession>
    <name>A0A182PTN8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PTN8"/>
    <dbReference type="STRING" id="199890.A0A182PTN8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010324-RA">
        <property type="protein sequence ID" value="AEPI010324-PA"/>
        <property type="gene ID" value="AEPI010324"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010324"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040019">
        <property type="term" value="P:positive regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07845">
        <property type="entry name" value="STKc_CDK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000533">
        <property type="entry name" value="cyclin-dependent kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044093">
        <property type="entry name" value="STKc_CDK10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF508">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010324-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="401" mass="45548" checksum="86779404A9FED860" modified="2016-09-07" version="1">MTSDYADYRDPNRPVQRKGMLMNFCTKGYTEIRPQDVYGKCRYVSSFQKCNRVGEGTYGIVFRAKDTVSNEIVALKKVRIDQDIFKDGFPISGLREIQILKNCKHENIVQLKEVVVGNSLESIFLVMEFCEQDLASLLDNMETPFSESQVKCIIIQLLKGLKYLHENYIIHRDLKVSNLLLTDTGCLKIADFGLARYLNHGNKPMTPGLVTLWYRPPELLFGAKTQTTAVDMWATGCILGELLIHKPLLPGTSEISQIELIINLLGTPTAMIWPDFDSLPLVQNFTLKEQPYNNLKSKFPFLSSNGYDLLNSLFMYNPECRASAERCLLSTYLREPPLPCDPNLMPTFPHHRDLKKTTPAKQDDPRKRTTGLSNSKPPFDVGQAPTISDLLGSLIKKRRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTU2</accession>
    <name>A0A182PTU2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTU2"/>
    <dbReference type="STRING" id="199890.A0A182PTU2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010378-RA">
        <property type="protein sequence ID" value="AEPI010378-PA"/>
        <property type="gene ID" value="AEPI010378"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010378"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12671">
        <property type="entry name" value="RRM_CSTF2_CSTF2T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.70:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.630:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000061">
        <property type="entry name" value="cleavage stimulation factor subunit 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="283"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010378-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="401" mass="44034" checksum="01A22DC55C527E9C" modified="2016-09-07" version="1">MDRHDQTLMDKSMRSVFVGNIPYEATEEKLKDIFCEVGPVLSLKLVFDRESGKPKGYGFCEYKDQETALSAMRNLNGYEFGGRALRVDNACTEKSRMEMAALLQGPQVENPYGNECDPAETPDLIAKAVTQLQPDQMYEMMRQAKACIQNDPQEARNMLLENPQLTYALLQAAVVMRIVDSHTAVTFLHGRNEMPPVLTDDPMSALPARDQIHPAFGEPDGPVQFHDSDERHLLGERVAQQQQQQQGSTTMDMDLRIMDPFMMGHRGVPGDIVQANTSVLEPAFPPVPEVRPQPPQRPVDPRLQKDPRLEAAAAVSAASGPMGPNSKAQMPVSSALADRGAAAGEPKTKAAGAANDASDQEKAALIMQVLQLSDEQIALLPQDQRASILVLKEQISRNAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU01</accession>
    <name>A0A182PU01_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="AlphaFoldDB" id="A0A182PU01"/>
    <dbReference type="STRING" id="199890.A0A182PU01"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010437-RA">
        <property type="protein sequence ID" value="AEPI010437-PA"/>
        <property type="gene ID" value="AEPI010437"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010437"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000193">
        <property type="entry name" value="Protoporphyrinogen oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010437-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="478" mass="53023" checksum="82D958768EB5E216" modified="2016-09-07" version="1">MTAILGAGISGLAAGHYLLRKTPTLPLTIYEATERIGGWIRSDRCPDHGYVFEAGPRTIRPKGPAAGNTLELIEELGLTDQVYSISSNHTAARNRMIYAKGKLNLLPNSLGGVLKTVPPFTSPLYFAAFRDLLAGRSKTPLSDESMYSFVERRFGKEIADYAVSSMLCGICAGDAKEISVKFLMKDLFEREQRHGGVIVGLLKEALQKRKSKQPESGKKSATQMARLAERAKAENWSIYSIRGGLQTLPETLATELQTKGASIVTGTKFEELTFDRDRIVLRVDGKEQLLQHLVSSIPSYKLAKHVQKQHPQLAATLASIPFVDVCVINLQYRGGNLLKQDGFGFLVPPIENLPILGVIFDSCCFDMDDNTVLTVMMGGAWFEKWFGKNPSDEQLLDVALKNVKKILHIERQPDSFKINLLRKCIPQYTVGHQDRVKAIREYVEQHRLPLVLCGASYDGVGVNDVILSARKSVETMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU04</accession>
    <name>A0A182PU04_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UNC93-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU04"/>
    <dbReference type="STRING" id="199890.A0A182PU04"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010440-RA">
        <property type="protein sequence ID" value="AEPI010440-PA"/>
        <property type="gene ID" value="AEPI010440"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010440"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010440-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20568" checksum="59E6F4F4E461E610" modified="2016-09-07" version="1">MHGGGVDTDKHNGGDSASLREKVQLRRGEKWRILKNIITVSVAFMVQFTAFQGTANLQSSINAKDGLGTVSLSVVYAALVVSCIFLPTLVIRKLTVKWTLCVSMLCYAPYIASQFYPRFYTLLPAGVLLGLGAAPMWASKATYLTQLGQVYAKLTDQSVEAIIVRFFGFFFLAWQTAELWGNLISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU94</accession>
    <name>A0A182PU94_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU94"/>
    <dbReference type="STRING" id="199890.A0A182PU94"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010530-RA">
        <property type="protein sequence ID" value="AEPI010530-PA"/>
        <property type="gene ID" value="AEPI010530"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010530"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF106">
        <property type="entry name" value="CYTOCHROME P450 4G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010530-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="562" mass="64342" checksum="DDFD33061E1AE752" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVN8</accession>
    <name>A0A182PVN8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVN8"/>
    <dbReference type="STRING" id="199890.A0A182PVN8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011025-RA">
        <property type="protein sequence ID" value="AEPI011025-PA"/>
        <property type="gene ID" value="AEPI011025"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011025"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022242">
        <property type="entry name" value="TNP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12596">
        <property type="entry name" value="Tnp_P_element_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="2">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="3">
        <location>
            <begin position="110"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="4">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like C-terminal" evidence="1">
        <location>
            <begin position="359"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011025-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49832" checksum="641D13D1B9B5F3BE" modified="2016-09-07" version="1">MKVESVLEYDPATDEILGPYKYMQVALARGLFKNWKQPVFIGFDQSMKKGIMLSIITNLHEKGINVVAIVSDNCPANIACWKDLEATGFDHPFFCILSQKRVYVIPDAPHLLKLTRNWLIDHGFSIGHKKITSQTLFQIVNDRLNAEMRPVFKISKGHLVMTNQEKQNVSKAAQVLSRTVAISLQRYVSNEAANDLADFIETVYFWFCVSNSYSPLAKEHYEQSFNGNDHQKQALSDMYNLMKNSTVIGKHSLQTFQKSILIQINALQMLFDDMKRRHKVSFLSTYKINQDVLENFFSQLRQRGGVYDHPSPLSCIYRVRIMVLGKSPSIIHNQSGREQRKIIKPDEYLTSTGADVAGSEDQEQINSSENEEFISATVFSEAEINPRLPDVAEMESLNGMSQDKSDTVSTVSSTQLNMTEQESDGLEYIMGYLAMKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW84</accession>
    <name>A0A182PW84_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PW84"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011221-RA">
        <property type="protein sequence ID" value="AEPI011221-PA"/>
        <property type="gene ID" value="AEPI011221"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011221"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131999" evidence="2">
        <location>
            <begin position="24"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011221-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="385" mass="42269" checksum="BE8E372A0B864F60" modified="2016-09-07" version="1">MSRLLMCTGICLLLLSYGSVVWCYEDTAPYTVRRPLDTLFRGGQKHDGPVPELGLNGSGPHAAHDSHGSLANEYHQTQRQPLAVVRPLSEPVQHRASLHRVVEPGGPAAGGHHRWHVDQRPDAFGVGSAVPAFQRALPAIDIGSSGGVDDFIGHGGPPALDMLELPAPDPVLDPTDNEIGDNPLLAALGAISGPRVVVDREESAADPPHQPAGRVMESIDLIREQLERIKQEEDIEIKSNLLMKLLTELPEGPLPIVYIEDAAGKAGTVRRVEDDDDDDTADDGDDGDDEEGQLVGGRIRTEQLTPNGGKRSGRYYRRYPWKRQNARSRTYDAEARYLCVPSREDVFKLLVGLHENRIGNHQKTVNFCNRKRPAKAIFTNIRFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWQ0</accession>
    <name>A0A182PWQ0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1758 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWQ0"/>
    <dbReference type="STRING" id="199890.A0A182PWQ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011387-RA">
        <property type="protein sequence ID" value="AEPI011387-PA"/>
        <property type="gene ID" value="AEPI011387"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011387"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011387-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="153" mass="17283" checksum="CE6631C034A8D6E0" modified="2016-09-07" version="1">MRRMEAHVPVSGIGDSSEQVRQSIIARVKSPRSSYECTLRFLILKKVTLDLPTTNVNIANWKIPEHIGLADPQFNVMGKVDLLIGAEVFLDLLLQETYSLGPDLPTLRNSRIGWLISGSYIAKPSRDLNGLKRNKNAKNYFNGRQFKVKVENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWT8</accession>
    <name>A0A182PWT8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWT8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011425-RA">
        <property type="protein sequence ID" value="AEPI011425-PA"/>
        <property type="gene ID" value="AEPI011425"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011425"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011425-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="152" mass="17327" checksum="4779669BBBADB675" modified="2016-09-07" version="1">MSTGSSRKTTSQAAFERLAKVQELEREMAAKEFELKMASLKLEQEKLRLKLEDEYERGSHRSSITCTSKTEQWVRDQQNQFDAISATSEPTRMEPVAVNPTPIIPVAKTGRCCLTEDQVVTQQIYPKKLPTFRGSTKEWLVFISCYNDSTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWV6</accession>
    <name>A0A182PWV6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWV6"/>
    <dbReference type="STRING" id="199890.A0A182PWV6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011443-RA">
        <property type="protein sequence ID" value="AEPI011443-PA"/>
        <property type="gene ID" value="AEPI011443"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011443"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011443-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="157" mass="17830" checksum="F10BBE9EE1CC2BF9" modified="2016-09-07" version="1">MLEIWRSKTSILLPKHARTLLRTNRAPKSIANIAGGRYWYKGIGNCLHQKFRNIKLASNTVLSLNISIDGLPLHKSGRTTFWPILMNVDAMRHIKPMTVAIFCGDKKPTSVEQYLRPLVDEINMLYKDGIMLGSESTQTYIKIRAFIADSPARAFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYW8</accession>
    <name>A0A182PYW8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYW8"/>
    <dbReference type="STRING" id="199890.A0A182PYW8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015036-RA">
        <property type="protein sequence ID" value="AEPI015036-PA"/>
        <property type="gene ID" value="AEPI015036"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015036"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF103">
        <property type="entry name" value="CYTOCHROME P450 6BS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015036-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="501" mass="58040" checksum="9ED731D8C0A7DF06" modified="2016-09-07" version="1">MEVMDITITFGMVCIIIYLILVRRNRYWIERNIPQLNPELLFGDVRDVNKTYHIGEKFRQLYTQLKGKHPFGGIYMFTKPVALITDLELLKCIFVKDFQYFHDRGTYYNERDDPLSAHLFNLEGRKWKSLRNKITPTLTSGKMKMVFSTIVATGKQFQDFMLASVQGQTELELKDLLARYTTDVIGTFAFGIECNSVHNPDAEFRVMGKKFFTRPRNILQQFLMNAFPRVARLVGIRSILPEVSDFFMNVVRDTITYRVANNVQRNDFMDILIRMRSDSDIKSDDGTLTFNEIAAQAFVFFIAGFETSSSLVAFTLYELALNQEIQDEARKCVNEVLKRHGGILTYEAAMEMIYLDRVLKECLRKYPPISVHFRITSKDYIVPGTNSVLEAGTSVMIPVLGIHHDPEYFPDPERFDPERFTVEQEAQRHPYAWTPFGEGPRICVGLRFGMMQARVALIHLLTSFRFSCCSKTPVPMRYDLKNGILTPKEGMWLRLEKIDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PK94</accession>
    <name>A0A240PK94_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A240PK94"/>
    <dbReference type="STRING" id="199890.A0A240PK94"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015322-RA">
        <property type="protein sequence ID" value="AEPI015322-PA"/>
        <property type="gene ID" value="AEPI015322"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015322"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11328">
        <property type="entry name" value="AmyAc_maltase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015322-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="547" mass="61688" checksum="07391E668CDCBD79" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PL27</accession>
    <name>A0A240PL27_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PL27"/>
    <dbReference type="STRING" id="199890.A0A240PL27"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015386-RA">
        <property type="protein sequence ID" value="AEPI015386-PA"/>
        <property type="gene ID" value="AEPI015386"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015386"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018362">
        <property type="entry name" value="CCAAT-binding_factor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00686">
        <property type="entry name" value="NFYA_HAP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015386-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="364" mass="38183" checksum="741CC2F903D251D0" modified="2017-10-25" version="1">MLTMNNTATANTLSGITFSDLTAASAATGQGTGGLQLVQLSQVMPDPNSQQLFMQSLQQQLTGGTPAIQVIPISALPQQTVALAQGPPPGATLQAAPQQQQFVQYTLDGQTLLYQALPTPEAAYQSVNLPIVQLPATQTLGTAGTVPTYGNISNLQGNPVTFTQIPTATVAQTIPQHHHAQQHLQHHQQHPQLQTTATIDANTFQSIVAAPVTITPGATVVPVSQPQQIPMSSPVTTVTIGQPVQQIGVGGLGSSSSSSTTGNINGATTGPTSVSPGVVTLPDCTSHIVATTSGGGSGSGGEMEQEPLYVNAKQYKRILKRRQARAKLEAMGKIPKQRSKYLHESRHRHAMNRVRGEGGRFHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PPL3</accession>
    <name>A0A240PPL3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 186</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM186 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PPL3"/>
    <dbReference type="STRING" id="199890.A0A240PPL3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015217-RA">
        <property type="protein sequence ID" value="AEPI015217-PA"/>
        <property type="gene ID" value="AEPI015217"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015217"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026571">
        <property type="entry name" value="Tmem186"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13603">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13603:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015217-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="205" mass="23348" checksum="7FDD31A723A846FA" modified="2017-10-25" version="1">MLRTFHLLQNFGHTKGNVISSLFRRQPIFLHQPNINKLAFSNLVRHCSTNSAVASTEQPARANENDSESNATNWNTIYHFPSIMLTASLKRLKFYPMVCTGVSVPISIGLAYMDVWSMTTAEVVGAIGKEYLNISFLDAKGKRQNRIYSVDDLVSRTELPKSFLKMYFPVKNHENGDVYKLVHQYGEIYDVHAFNKIFGHEVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWM4</accession>
    <name>A0A3F2YWM4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWM4"/>
    <dbReference type="STRING" id="199890.A0A3F2YWM4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015464-RA">
        <property type="protein sequence ID" value="AEPI015464-PA"/>
        <property type="gene ID" value="AEPI015464"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015464"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000092">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="8"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015464-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="555" mass="62910" checksum="FEB1761AACEEEBD2" modified="2019-01-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P067</accession>
    <name>A0A182P067_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hormone-sensitive lipase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P067"/>
    <dbReference type="STRING" id="199890.A0A182P067"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000299-RA">
        <property type="protein sequence ID" value="AEPI000299-PA"/>
        <property type="gene ID" value="AEPI000299"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000299"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010468">
        <property type="entry name" value="HSL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06350">
        <property type="entry name" value="HSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="371"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="777"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000299-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="878" mass="97654" checksum="2D598564F02E5FD6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0B2</accession>
    <name>A0A182P0B2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0B2"/>
    <dbReference type="STRING" id="199890.A0A182P0B2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000344-RA">
        <property type="protein sequence ID" value="AEPI000344-PA"/>
        <property type="gene ID" value="AEPI000344"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000344"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000344-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="132" mass="15115" checksum="3E0504FC9444A23D" modified="2016-09-07" version="1">MDSGHNQSVPSITLESSAPVTEGIIIAKRYPDRSDNLYFLFIPLAVLVTVMLLSVVVYLMARRRHKIRSKYSYVPSFSFESSDLDDDREERETDHLLKGGKLRLEEQPPFEEESSENPFVAQRYGGSRELFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0Q8</accession>
    <name>A0A182P0Q8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0Q8"/>
    <dbReference type="STRING" id="199890.A0A182P0Q8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000490-RA">
        <property type="protein sequence ID" value="AEPI000490-PA"/>
        <property type="gene ID" value="AEPI000490"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000490"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000490-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="312" mass="35157" checksum="3CD3D4B4E8E8CA52" modified="2016-09-07" version="1">MAKEESKYGFKDKAKAEESLELLKSEDHKYQLLTVRGLIGRAKRVLTLTKAEDKINNIKAAIETFEQWLEANSSTSTKNAKPKDTEDKVETVPGLGFKDKQAAEQTLSILEGRDPDYQKLAIKGLIGSAKRVIPATKNEDKLKSIKEAVALFEDFLDRFDREERGKQNMPYLSIDLIRQLPTPQGDKPDKLVAEFLDCYETQAKGNYKHLRTKSPKEGTKTWDIVRNAKLKALKPDSSVKLFDQDGKPTELHLQMVQWAYSPQVEKLKSYANSLASSNKATKPSRKRSHSSSSSSGDEKAKESKKGHKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0S0</accession>
    <name>A0A182P0S0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0S0"/>
    <dbReference type="STRING" id="199890.A0A182P0S0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000502-RA">
        <property type="protein sequence ID" value="AEPI000502-PA"/>
        <property type="gene ID" value="AEPI000502"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000502"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006959">
        <property type="term" value="P:humoral immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21806">
        <property type="entry name" value="DEFL_defensin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.10:FF:000005">
        <property type="entry name" value="Defensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645:SF0">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="7" id="KW-0211">Defensin</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012045825" description="Invertebrate defensins family profile domain-containing protein" evidence="10">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="11">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000502-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="102" mass="10401" checksum="AD51302899B7578F" modified="2017-12-20" version="2">MKCATIVCAIAVVLAATVFASGVHAAPEEHAAVAGSAALNTLLDELPEETHHAALENYRAKRATCDLASGFGVGSSLCAAHCIARGNRGGYCNSKAVCVCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0T8</accession>
    <name>A0A182P0T8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PARK2 co-regulated</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0T8"/>
    <dbReference type="STRING" id="199890.A0A182P0T8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000520-RA">
        <property type="protein sequence ID" value="AEPI000520-PA"/>
        <property type="gene ID" value="AEPI000520"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000520"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF2">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000520-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28963" checksum="119EC3F1A7296231" modified="2016-09-07" version="1">MAKSASFLFEVRPLTATVRSAKPVRSVKSASAAMRPVPAFSIESLQKNTYVMGPPKAQKQRYMIQPKATSFRMYYERGDLPIKMEYLTGGDKIAWTVDIDKLDYGLYLPLFFDGLSETRHPYKTYARQGVQDLLSHGGDKIYPVIPQLIIPIKNALNTRNVEVMCVTLKIIQQLVMSSDLIGPALVPFYRQLLPMFNAYKVKNINSGDAIDYGQKNNMNVGDLIDETLQVLERHGGEDAFINIKYMVPTYESCYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P100</accession>
    <name>A0A182P100_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P100"/>
    <dbReference type="STRING" id="199890.A0A182P100"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000582-RA">
        <property type="protein sequence ID" value="AEPI000582-PA"/>
        <property type="gene ID" value="AEPI000582"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000582"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000582-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="125" mass="12926" checksum="06EC81329C1CF5C5" modified="2016-09-07" version="1">MSTEHPAAGELLVNATAATAAAVSSTAKANIAVRVTEAAPAAALAIDPIINHVGDGIFLQAKTAQIFAGICVWMALFITCQQHLPTVLKNGQTISLSCHEQTTMLLLLLLLLCGTVACSPRTSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1W1</accession>
    <name>A0A182P1W1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4739 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P1W1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000895-RA">
        <property type="protein sequence ID" value="AEPI000895-PA"/>
        <property type="gene ID" value="AEPI000895"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000895"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031764">
        <property type="entry name" value="DUF4739"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15893">
        <property type="entry name" value="DUF4739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4739" evidence="2">
        <location>
            <begin position="593"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="943"/>
        </location>
    </feature>
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        <location>
            <begin position="972"/>
            <end position="1009"/>
        </location>
    </feature>
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        <location>
            <begin position="1051"/>
            <end position="1152"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
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        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
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        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
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        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
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        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
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        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="991"/>
        </location>
    </feature>
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        <location>
            <begin position="992"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1079"/>
        </location>
    </feature>
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        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000895-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1298" mass="140616" checksum="8FDD0C11EF8AA912" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P359</accession>
    <name>A0A182P359_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P359"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001343-RA">
        <property type="protein sequence ID" value="AEPI001343-PA"/>
        <property type="gene ID" value="AEPI001343"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001343"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47111">
        <property type="entry name" value="BCDNA.LD29892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47111:SF1">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001343-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="92" mass="10623" checksum="30905C0D6D9614F8" modified="2016-09-07" version="1">MFCSVDCMARAQTKYHRHECGLVQDIWKVGGIKAVLAYRRVASEFASFKDLPSAKDYLELTHIHLDPTIELMHFGWHHDATLHGSGRKRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3J3</accession>
    <name>A0A182P3J3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Leucine-rich repeat-containing protein 59</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for nuclear import of FGF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with SGO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3J3"/>
    <dbReference type="STRING" id="199890.A0A182P3J3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001478-RA">
        <property type="protein sequence ID" value="AEPI001478-PA"/>
        <property type="gene ID" value="AEPI001478"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001478"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000645">
        <property type="entry name" value="Leucine-rich repeat-containing protein 59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="163"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001478-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="298" mass="34315" checksum="ABC261465C0491DC" modified="2016-09-07" version="1">MAMKQNENEEKIYVRERLTDNVLDLSLMNISSVPVQEIKPLRRATVLDLSNNRISIIESNFTDLTQLTQIDLSKNRITSICDDFGLLTNLRRLDLYKNQLTRLPLTFGRLKNLKYLDLKENPLNPAFKKLIGTCSDTNDCLVAATRAVEFMKQVERRVMDDRAKERKVREERQRQLDEDRQRLQKEKATEEEKPVDEQKADKAKRKRKQAGAQGETINCDDAKAKTTSKAKAKTNQGGTKQNAAAASGFRHSSILWLLMLLLLAGTYMLYTKYNDVLQMAREGTVRETREAILEEYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3V1</accession>
    <name>A0A182P3V1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P3V1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001587-RA">
        <property type="protein sequence ID" value="AEPI001587-PA"/>
        <property type="gene ID" value="AEPI001587"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001587"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056467">
        <property type="entry name" value="eWH_GTF3C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="167"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="8">
        <location>
            <begin position="553"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1204"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1855"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1860"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1887"/>
            <end position="1896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001587-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2055" mass="235584" checksum="54A251E1BDF357AF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3W1</accession>
    <name>A0A182P3W1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in calcium binding and microtubule stabilization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3W1"/>
    <dbReference type="STRING" id="199890.A0A182P3W1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001597-RA">
        <property type="protein sequence ID" value="AEPI001597-PA"/>
        <property type="gene ID" value="AEPI001597"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001597"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="7">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001597-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="171" mass="19530" checksum="05ED81C89BE9E618" modified="2016-09-07" version="1">MKIWKDVFTGDEMFSDTYKVKLVDDVMYEVYGKHVSRTLGDVQLDGANPSAEEAEEGTEAATESGVDIVLNHRLVETGFSDKKQFTTYLKDYMKKLVTRLEEKSPGEVEVFKTNINKVMKDLLGRFKDLQFFTGESMDCEGLIAMLEYRDINGESVPVLLCFKHGLEEEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4A5</accession>
    <name>A0A182P4A5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoporin NUP35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">35 kDa nucleoporin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin NUP53</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nup35 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4A5"/>
    <dbReference type="STRING" id="199890.A0A182P4A5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001741-RA">
        <property type="protein sequence ID" value="AEPI001741-PA"/>
        <property type="gene ID" value="AEPI001741"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001741"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12441">
        <property type="entry name" value="RRM_Nup53_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000095">
        <property type="entry name" value="Putative Nucleoporin NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017389">
        <property type="entry name" value="Nucleoporin_NUP53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038119">
        <property type="entry name" value="Nucleoporin_NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8 12" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="14">
        <location>
            <begin position="231"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001741-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="381" mass="41756" checksum="4634EF1CFA175824" modified="2016-09-07" version="1">MEPMTLGSPSGSSLSGATGAGGTGYLPSFLMGDPPTTPRPNTLSPTRGRSSLAYTHGLMSSPPEGLRSPTMQQQQQQQHILGFNHQQHQQQQQHQQLSSSFMHPHTPQGHHLPHSQRYLQNTAQPVQAATNQFRNESFDANSSITGPPTQGLFDSWRKEKQLLQTPIRNQQQSDTTAVPFNESYNNQSGFNLSRVMSPIPVDYNQRNASVAATISPIGAGQQQQTHVQQAARSSNWVTVFGFPQNAASKILSHFIGIGTIVDKQPAPQNGNWVHLRYSSRLECDRALNYNGRVISEGLMIGVQYCNDPTILGKENEGNENLDSTTPAGGVSSPDKPLWRVRSLMNMSYSAMQDPQAVISAPPVQKRGTGIVNKAMDLFFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4S3</accession>
    <name>A0A182P4S3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4S3"/>
    <dbReference type="STRING" id="199890.A0A182P4S3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001909-RA">
        <property type="protein sequence ID" value="AEPI001909-PA"/>
        <property type="gene ID" value="AEPI001909"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001909"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001909-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="259" mass="30030" checksum="F6BD7D6C133A3891" modified="2016-09-07" version="1">MPQNEYIERHIKLYGRRLDYEERKRKREAREPKKRAAMARKLRGMKAKLFQKQRRNEKIQMKRKIQAHEEKKVKKTTEKVEDGALPPYLMDRGIQSSAKVLSNMIKQKRKEKAGKWDVPIPKVRAQGDAEVFKVIRSGKTKRKAWKRMVTKVTYVGENFTRKPPKYERFIRPMALRFNKAHVTHPELKATFYLPIIGVKKNPSSPMYTSLGVITKGTVIEVNISELGLVTQSGKVVWGKYAQVTNNPENDGCINAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4Z5</accession>
    <name>A0A182P4Z5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4Z5"/>
    <dbReference type="STRING" id="199890.A0A182P4Z5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001982-RA">
        <property type="protein sequence ID" value="AEPI001982-PA"/>
        <property type="gene ID" value="AEPI001982"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001982"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000172">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4 5" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="7">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="8">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001982-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="128" mass="13739" checksum="F9C6AA014842B21C" modified="2016-09-07" version="1">MKKITKSSRAGLTFSVSRVSSTLRKGKYASRIGVGSSVYLTAVLEYLAAEVLELAGNAARDNHKSRLTPRHIQLAIRNDEELSKLLQGTTISQGGVMPNIHSVLLPRKTGAKSTTGTLPASQGLSQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P562</accession>
    <name>A0A182P562_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 5A</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of a large pre-ribosomal ribonucleoprotein (RNP) complex, that consists of at least 62 ribosomal proteins, 45 nonribosomal proteins and both pre-rRNA and mature rRNA species. Within this complex directly interacts with TCOF1 in an RNA-independent manner. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL or FBLL1 assemble stepwise onto the snoRNA. Interacts with NOP1 and NOP58. Interacts with NUFIP1, RUVBL1 and RUVBL2; RUVBL1:RUVBL2 seem to bridge the association of NOP56 with NUFIP1. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with NOP2 and FBL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P562"/>
    <dbReference type="STRING" id="199890.A0A182P562"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002050-RA">
        <property type="protein sequence ID" value="AEPI002050-PA"/>
        <property type="gene ID" value="AEPI002050"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002050"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="293"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="429"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002050-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="520" mass="57511" checksum="A3F7F2175F9A932A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5L1</accession>
    <name>A0A182P5L1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5L1"/>
    <dbReference type="STRING" id="199890.A0A182P5L1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002201-RA">
        <property type="protein sequence ID" value="AEPI002201-PA"/>
        <property type="gene ID" value="AEPI002201"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002201"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF218">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 65AA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130927" evidence="4">
        <location>
            <begin position="18"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002201-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1089" mass="119591" checksum="1CC5D39DB143B20C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5M2</accession>
    <name>A0A182P5M2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P5M2"/>
    <dbReference type="STRING" id="199890.A0A182P5M2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002212-RA">
        <property type="protein sequence ID" value="AEPI002212-PA"/>
        <property type="gene ID" value="AEPI002212"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002212"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11328">
        <property type="entry name" value="AmyAc_maltase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130833" description="alpha-glucosidase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="36"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002212-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="610" mass="71040" checksum="88981851ED4962F0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6L8</accession>
    <name>A0A182P6L8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P6L8"/>
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        <property type="protein sequence ID" value="AEPI002566-PA"/>
        <property type="gene ID" value="AEPI002566"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002566"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1072"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="401"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="960"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="700"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1249"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1288"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1422"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1483"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="713"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1252"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1288"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1424"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1497"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1517"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1529"/>
            <end position="1542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002566-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1552" mass="173162" checksum="57A6833F29CF6AE9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6M5</accession>
    <name>A0A182P6M5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Presenilin</fullName>
            <ecNumber evidence="8">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A22A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A182P6M5"/>
    <dbReference type="STRING" id="199890.A0A182P6M5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002573-RA">
        <property type="protein sequence ID" value="AEPI002573-PA"/>
        <property type="gene ID" value="AEPI002573"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002573"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034205">
        <property type="term" value="P:amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.100:FF:000001">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002573-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="517" mass="57124" checksum="BCE4E8DD04F20C98" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6U1</accession>
    <name>A0A182P6U1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNF8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6U1"/>
    <dbReference type="STRING" id="199890.A0A182P6U1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002641-RA">
        <property type="protein sequence ID" value="AEPI002641-PA"/>
        <property type="gene ID" value="AEPI002641"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002641"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000632">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="10"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002641-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="250" mass="28143" checksum="C8837A3C19CCF564" modified="2016-09-07" version="1">MRRRAGVGAIQKQRLEAEKYKDKGTELQESQFEQMVKQMEALKENLEEFAQKHRNEIKKNPQFRRQFQEMCAAIGVDPLASAKGFWSVLGMGDFFYELSVQVVEVCLAHNHITGGLMELEELRNRLVAARGKSQIHQEITTEDILMATKKLKIFGNGFSVYSVGKNRYMVQSIPGELSLQETTVLSAASNQGQGFVTVASLVSDLGWTQARAEQAVEKMLGEGMAWIDTQGEEKSYWFPSLFPGRLTAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7G0</accession>
    <name>A0A182P7G0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rhomboid-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7G0"/>
    <dbReference type="STRING" id="199890.A0A182P7G0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002862-RA">
        <property type="protein sequence ID" value="AEPI002862-PA"/>
        <property type="gene ID" value="AEPI002862"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002862"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000050">
        <property type="entry name" value="Rhomboid-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051739">
        <property type="entry name" value="Rhomboid_IM_Serine_Proteases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840:SF10">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002862-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="270" mass="29902" checksum="CACD426A9352F3BF" modified="2016-09-07" version="1">VWRFVTYTFLHAGSVHLVLNIIIQILVAFPLETEQGHGKVLLVYFAGIVAGGLGASVFEPTLMVGASAGVYCLLISHIPHITLNFRTLSYRYYRLIAVLMLCISDVMYSIRHCLTKGNIQPRIGVAAHVSGAVCGLLVGFVIYRSKVEPDASKAIVMFRSLRYLAAVLLLAWLGCTVLYNLDRSHRAWMESDRQNRPLESEREPFLACGGSGSEGSETSSLEYELLCTEELKEKARIFAIDLERGRKRSENGTTRIEITEQLITGSGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7U8</accession>
    <name>A0A182P7U8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FHA_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7U8"/>
    <dbReference type="STRING" id="199890.A0A182P7U8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003001-RA">
        <property type="protein sequence ID" value="AEPI003001-PA"/>
        <property type="gene ID" value="AEPI003001"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003001"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01625">
        <property type="entry name" value="HAD_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000078">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003001-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="496" mass="56351" checksum="8CB051DAAAB590AD" modified="2016-09-07" version="1">MKTPSQPLLGLILCLTPNLEEGYVLVNVLGLNPSLLNGFKLDRNINYAALHGDILELVPGKYKYVFEFVYETTARAVGNPSAPHTSKQRSEGRIGGSNDNSDSTITPTAEGWWETPPFKGLHIYTSAGVVASKKVAAYDMNGTLIKSNYDVLFPESFDDWQIAFPEVPGKLKKLHACGYKLVIFTNQAAIGKYEMEIFEFRRKIEAVVRKLGVPMQVFISTGPEKYRKPRTGMWDALCERQMQQTGVAINPARCFYVGDAAGRPNLKKPFNHKKDHSCADRLLAMNIGIRFLTPEQHFQNLPKQPWIKPKFNPRKVCRLTANGPLLTPPGALLAEPRQEVIVMVGFPGSGKSHFVWNHLAPKGYDVVNRDTLGSWKNCEVQMVLSLRQGNSVVVDHLNPDVETRKRYVLVARRAKIPIRCFLMDVSYKHARHNIEFRKMTHWSHSSMTDMIFNLYTSKFQEPTIAEGFTEIVKVNFVPDFDTYRYADLYRMYLLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7V5</accession>
    <name>A0A182P7V5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P7V5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003008-RA">
        <property type="protein sequence ID" value="AEPI003008-PA"/>
        <property type="gene ID" value="AEPI003008"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003008"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF89">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130947" description="Peptidase M14 domain-containing protein" evidence="13">
        <location>
            <begin position="26"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="14">
        <location>
            <begin position="933"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="162"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="239"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="323"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="442"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="623"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="560"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003008-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1293" mass="144351" checksum="052A94C815B10EEE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7W9</accession>
    <name>A0A182P7W9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TBC domain-containing protein kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7W9"/>
    <dbReference type="STRING" id="199890.A0A182P7W9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003022-RA">
        <property type="protein sequence ID" value="AEPI003022-PA"/>
        <property type="gene ID" value="AEPI003022"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003022"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000043">
        <property type="entry name" value="AGAP000552-PA-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001232">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000015">
        <property type="entry name" value="TBC domain-containing protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF168">
        <property type="entry name" value="TBC DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="462"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="749"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003022-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="99552" checksum="659A39F938F9BFD0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7Y5</accession>
    <name>A0A182P7Y5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7Y5"/>
    <dbReference type="STRING" id="199890.A0A182P7Y5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003038-RA">
        <property type="protein sequence ID" value="AEPI003038-PA"/>
        <property type="gene ID" value="AEPI003038"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003038"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003038-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="220" mass="24642" checksum="82FA7815002AD5C5" modified="2016-09-07" version="1">MDIILALQWVRDNIASFGGDPKRITVVGHDTGAALANLVLISKSGKGLIHRAILLSGSALSPWALIPDPDAVRLEVSQQMACHLVPGRNGRKPSTDDITECLRDKPIEALMGVRLTSVRFMPSWGPFLPLEDSMDPEFAMEHSGEGFITSELMLGMTTTESYNDFSASDIQYGLEEDQRNRLLRTYIRNAFTFHLNEIFSAVRNEYTDWDKPIQHPINIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8F4</accession>
    <name>A0A182P8F4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P8F4"/>
    <dbReference type="STRING" id="199890.A0A182P8F4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003207-RA">
        <property type="protein sequence ID" value="AEPI003207-PA"/>
        <property type="gene ID" value="AEPI003207"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003207"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003207-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="256" mass="28975" checksum="7F8A073767BA8364" modified="2016-09-07" version="1">MSIIFNSEMKAIYLLSVGLIYFCKPVTSLGAGVWFRHLVPRSFVAQHVDTPSSSSSLSTRTDARQHEPLAHQQCEEPNTTLTPVENYKTNPYCFRFTWMGPKYNKDTPYKNLSCDNILKKAKGIPCFHPLVITNNTNVPDTNYMWEEYKDKPSQIACRLVRGEVCARYSYRYNGAIENITYMCAKLNVDNESSTSSSCFKEDRQGREIEVCVCESAAGRTPCNRSAIVLADGAPIAPMMLVLAMIQLLLIKCLQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8M6</accession>
    <name>A0A182P8M6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8M6"/>
    <dbReference type="STRING" id="199890.A0A182P8M6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003279-RA">
        <property type="protein sequence ID" value="AEPI003279-PA"/>
        <property type="gene ID" value="AEPI003279"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003279"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000004">
        <property type="entry name" value="Sodium/potassium/calcium exchanger 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF72">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER NCKX30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="37"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003279-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="213" mass="24198" checksum="B3A85DF203685FF3" modified="2016-09-07" version="1">MEEATFKNQTAAKKDPLFPDDLFTDEQRRNGAIILHIIGVIYMFVALAIVCDEFFVPSLDVIIEKLGITDDVAGATFMAAGGSAPELFTSIMGVFVSFNDVGIGTIVGSAVFNILFVIGMCALFSKTILSLTWWPLFRDCTFYSVSLLTLIYFFRDNKIYWWEALVLFIIYILYAVFMKFNQQVERCVKKIIYKNKVTRVRSTDQLMPARIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P984</accession>
    <name>A0A182P984_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P984"/>
    <dbReference type="STRING" id="199890.A0A182P984"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003488-RA">
        <property type="protein sequence ID" value="AEPI003488-PA"/>
        <property type="gene ID" value="AEPI003488"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003488"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000508">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002716">
        <property type="entry name" value="Zinc finger protein 212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003488-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="484" mass="54831" checksum="A6879EB2D71DE055" modified="2016-09-07" version="1">MMPNFYDGSRPTMVPTSSNLPVLLGNTVNQGDPNSKKLAQAHFDLEATLQTIDNEVLDGEEGSCPICNKTFSRKTSLLNHIRNHSAEKKYVCEFCQKGFTQQANLRNHVRIHTNERPYVCVDCGKAFTQITNLNNHRRLHTGERPYVCIESNCGRSFAQVTNLNNHMKTHHKTTLYVCNQCPRKFSQCPDKSFKQQSHLQQHMKIHGTNFGYSCTKCEEKFIQESHLLLHMKQHGDYACTMCSMTFNDEVLLKKHVQRHVDGRYLTCPVISCSEGFTMKNHLTKHMQMHHPAVDLKKLGAQPGGNKTPKHFCHYHNCNESFDTADGLSNHLRMAHGLPIALPLSLPVDDKKLIQHGLHGLNGMETPPPPSTQHLLHSGPLHPAASVMNASFQSYQSQINQANQQHQPNNGGDNKLKVLSDKMSNFNRIKTELQANMLAQTQNLFGISNTLSNTFNVQPKLICTYCYNVFKTPQTLSRHIEKFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9A7</accession>
    <name>A0A182P9A7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hyaluronidase</fullName>
            <ecNumber evidence="5">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 5">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182P9A7"/>
    <dbReference type="STRING" id="199890.A0A182P9A7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003511-RA">
        <property type="protein sequence ID" value="AEPI003511-PA"/>
        <property type="gene ID" value="AEPI003511"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003511"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001329">
        <property type="entry name" value="Venom_Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF35">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00847">
        <property type="entry name" value="HYALURONDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003511-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="158" mass="18218" checksum="99D3045F7405046A" modified="2016-09-07" version="1">MCNQFGFDFTTVNRTYSVRQNRNDTFRGNAVSILYDPGKFPALLEKPSTKTLYKRNGGVPQEGNLTEHLEIFDRHLDELVPDRNFSGIGIIDFESWRPIYRQNFGSLQPYKDLSVKIERERHPYWSANHLEREVGKQINFFSSVNDTAVSPGNGNSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9B5</accession>
    <name>A0A182P9B5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-protein ligase E3C</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">HECT-type ubiquitin transferase E3C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RTA-associated ubiquitin ligase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with 26S proteasomes. Interacts (via the HECT domain) with UBE2D1 and, less efficiently, with UBE2L3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UBE3C family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P9B5"/>
    <dbReference type="STRING" id="199890.A0A182P9B5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003519-RA">
        <property type="protein sequence ID" value="AEPI003519-PA"/>
        <property type="gene ID" value="AEPI003519"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003519"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000014">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="786"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="685"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003519-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1123" mass="128247" checksum="EB5C6C0BB87C16F8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9D6</accession>
    <name>A0A182P9D6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Integrator subunit 8 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P9D6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003541-RA">
        <property type="protein sequence ID" value="AEPI003541-PA"/>
        <property type="gene ID" value="AEPI003541"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003541"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016715">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.310:FF:000004">
        <property type="entry name" value="DBH-like monooxygenase protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.230:FF:000001">
        <property type="entry name" value="Monooxygenase, DBH-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020611">
        <property type="entry name" value="Cu2_ascorb_mOase_CS-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038751">
        <property type="entry name" value="INTS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028460">
        <property type="entry name" value="Tbh/DBH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057980">
        <property type="entry name" value="TPR_INTS8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13350">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13350:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25756">
        <property type="entry name" value="TPR_INTS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00767">
        <property type="entry name" value="DBMONOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00084">
        <property type="entry name" value="CU2_MONOOXYGENASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOMON" evidence="14">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003541-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1621" mass="183880" checksum="EB19294464E91626" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9F6</accession>
    <name>A0A182P9F6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S16</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9F6"/>
    <dbReference type="STRING" id="199890.A0A182P9F6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003561-RA">
        <property type="protein sequence ID" value="AEPI003561-PA"/>
        <property type="gene ID" value="AEPI003561"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003561"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000184">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003561-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="148" mass="16820" checksum="CD357D64C2487428" modified="2016-09-07" version="1">MPKARKEKVNAVQVFGRKKTATAVAYCKRGKGLLRVNGRPLDQIEPKILRYKLQEPLLLLGKEKFAGVDIRIRVSGGGHVAQIYAIRQAISKALVSFYQKYVDEASRKELKDILTQYDRTLLVADPRRCEPKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9R3</accession>
    <name>A0A182P9R3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
            <location evidence="2">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9R3"/>
    <dbReference type="STRING" id="199890.A0A182P9R3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003667-RA">
        <property type="protein sequence ID" value="AEPI003667-PA"/>
        <property type="gene ID" value="AEPI003667"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003667"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19512">
        <property type="entry name" value="RecA-like_ATAD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000470">
        <property type="entry name" value="ATPase family, AAA domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021911">
        <property type="entry name" value="ATAD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF0">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12037">
        <property type="entry name" value="ATAD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="349"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003667-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="597" mass="67383" checksum="30D0B5C5ED9D77BF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAD3</accession>
    <name>A0A182PAD3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAD3"/>
    <dbReference type="STRING" id="199890.A0A182PAD3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003887-RA">
        <property type="protein sequence ID" value="AEPI003887-PA"/>
        <property type="gene ID" value="AEPI003887"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003887"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048729">
        <property type="term" value="P:tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001064">
        <property type="entry name" value="Zinc finger protein 425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041697">
        <property type="entry name" value="Znf-C2H2_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16622">
        <property type="entry name" value="zf-C2H2_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003887-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="299" mass="34323" checksum="9F73FD59F0F6466C" modified="2016-09-07" version="1">MESVAPVSVPPADQRVSTGNGKCYICGERFSSEQELDRHLNSQHAAELIPYRCETCDYDRCLPIRSMRAINKHFALHDVQERMHKCSYCPLRFRTERNRQSHVRLYHRGGARNVSDKMHDLQQDCLSTHQKTTAERSEKDRFQCCHCGRTYTTANALKRHENTHTLGVRYACRQCGKVFAKLDCLTQHERIHSQTRPYGCDQCGQTFIQLGHLRLHKRARHSGERPHVCGICNRGFRCRTALTVHGRIHTGEKPFCCEVCSVRFSDAGTLRKHGAVHREKSSSEISNSSRNCREVAMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB85</accession>
    <name>A0A182PB85_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PB85"/>
    <dbReference type="STRING" id="199890.A0A182PB85"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004190-RA">
        <property type="protein sequence ID" value="AEPI004190-PA"/>
        <property type="gene ID" value="AEPI004190"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004190"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="159"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="804"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="610"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="681"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004190-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="831" mass="86357" checksum="5441B5ACDD91AD06" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBL3</accession>
    <name>A0A182PBL3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBL3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004318-RA">
        <property type="protein sequence ID" value="AEPI004318-PA"/>
        <property type="gene ID" value="AEPI004318"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004318"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004318-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="127" mass="14549" checksum="AB268A1BDB529F43" modified="2016-09-07" version="1">MTQYARMNESLAVLPGHSPCYGQLYFFDPSLEGQYGTMLNARVSASDGELNRNILATLQRVLPTHNPIAAMFKHAYERMFVRDDLRLSIRLRAPQVWINAVTTKPAADEVGGMFVYDADYRRRRAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBM4</accession>
    <name>A0A182PBM4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription cofactor vestigial-like protein 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBM4"/>
    <dbReference type="STRING" id="199890.A0A182PBM4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004329-RA">
        <property type="protein sequence ID" value="AEPI004329-PA"/>
        <property type="gene ID" value="AEPI004329"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004329"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001223">
        <property type="term" value="F:transcription coactivator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006627">
        <property type="entry name" value="TDU_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028184">
        <property type="entry name" value="VGLL4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17604:SF7">
        <property type="entry name" value="TONDU-DOMAIN-CONTAINING GROWTH INHIBITOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17604">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15245">
        <property type="entry name" value="VGLL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00711">
        <property type="entry name" value="TDU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004329-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32264" checksum="22FDC78A83BF4612" modified="2016-09-07" version="1">MIRDPGGTSPNENQDSPPSPKYDRILGRPPPLDDTEIPLDMTVRRKDSSDGQGSPTAIDQSRDGPINLNVRPSVITKAPPPPIKKRISHMHTNGEIVLKSSIRTTTSTTVESAPIVNVSSTYCDVSIEEHFRRSLGPTYSSIYGDKHQHQSPQQQQQQQQPPTLNVLNNNISTGGNGPPPFVPESPVHHLSSDPAPPIPLVPASVLPPSPGAPSSAASVAAISLTSPKHLHQQPPPAAISPASLTTTMSLSSSSPSSSLASSPAPFLTTQQQKRPGSGEEVDDHFAKALGETWKKIQESNMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBW5</accession>
    <name>A0A182PBW5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBW5"/>
    <dbReference type="STRING" id="199890.A0A182PBW5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004421-RA">
        <property type="protein sequence ID" value="AEPI004421-PA"/>
        <property type="gene ID" value="AEPI004421"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004421"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004421-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="811" mass="86015" checksum="BA813A406156E882" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC74</accession>
    <name>A0A182PC74_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PC74"/>
    <dbReference type="STRING" id="199890.A0A182PC74"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004529-RA">
        <property type="protein sequence ID" value="AEPI004529-PA"/>
        <property type="gene ID" value="AEPI004529"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004529"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036449">
        <property type="term" value="C:microtubule minus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032940">
        <property type="entry name" value="CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058042">
        <property type="entry name" value="CAMSAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022613">
        <property type="entry name" value="CH_CAMSAP_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595:SF0">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11971">
        <property type="entry name" value="CAMSAP_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25532">
        <property type="entry name" value="CH_CAMSAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="145"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004529-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="382" mass="41210" checksum="E0F6089414EC2BDF" modified="2016-09-07" version="1">AKQRASVRWLLSKAYNNRVPEILKDPFYRDHVGQDHLKPQIVVGLGNASIYCQVLSNIYSDPNYQSLNHWSILQTLSRKGVPLNESSDQPLTETVLIQTNPLRINAHMTVIEALMVLYAKEVASSGRISSALERISGRSVAPTVQHHEAALLNWISHVCGALKKRIDYEMSANGGSGAVDEYGQRHQSPDVPPVRDFRELCDGVCLAYLISYYCPKLVPWHSVKFNHVPTIEDSIHNILIVSNFSERSLPYTVFHMSPEDITYMRGSMKQNLVVLLADLFNLFEIHPAKCVCYPGMEQQSPAGATNEHGIAHRRGFANQPTIAAIPDLRPGLDSPPSSSGGSGTSSSGGGGGGGGGGGGGAGCSSASGNGAINRPPFQGLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC84</accession>
    <name>A0A182PC84_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC84"/>
    <dbReference type="STRING" id="199890.A0A182PC84"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004539-RA">
        <property type="protein sequence ID" value="AEPI004539-PA"/>
        <property type="gene ID" value="AEPI004539"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004539"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000637">
        <property type="entry name" value="AGAP011682-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000076">
        <property type="entry name" value="phospholipase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF150">
        <property type="entry name" value="FI01825P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131088" description="Lipase domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="104"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="431"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="767"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004539-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1046" mass="111668" checksum="E657F5930A6132F9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCA9</accession>
    <name>A0A182PCA9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCA9"/>
    <dbReference type="STRING" id="199890.A0A182PCA9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004564-RA">
        <property type="protein sequence ID" value="AEPI004564-PA"/>
        <property type="gene ID" value="AEPI004564"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004564"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF680">
        <property type="entry name" value="PROTON-COUPLED AMINO ACID TRANSPORTER 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="60"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004564-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="475" mass="52658" checksum="F87BA8C438B41F2C" modified="2016-09-07" version="1">MTVDKGHTNTAFVGDEAINGKKPPQAKTIDPNMYTLEIQEKKPGLEADYDPFQHRLVEHPTTNNETLIHLLKGSLGTGILAMPNAFHHAGWTVGVIGTVLIGLLCTYCIHLLIKAEYELCKRKRVPSLNYPAVTQTALLEGPEALKPLSKIIIHIVNVFLLIYQLGTCCVYVVFVSSNIKAIADYYTESDTDVRLYMLIILLPLILINWVRNLKFLAPFSTIANFVTLVSFGIILYYIFREPISFEDREQVGTMSGFALFFGTVLFALEAIGVILPLENEMKTPKKFGGNFGVLNKAMILIVTLYVGMGFFGYLNYGSAIKGSITLNLPEEEILAQCVKGMLAFAIYITHGLACYVAIDITWNDYLKKNLGDSPRSIFYEYIARTVLVLITFLLAVAIPNLELFISLFGALCLSALGIAFPALIQTCTYWHHRKGLAKVWMVAKNSIIGVVAILGLVIGTSTSMIEIIHTFGHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDB7</accession>
    <name>A0A182PDB7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDB7"/>
    <dbReference type="STRING" id="199890.A0A182PDB7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004922-RA">
        <property type="protein sequence ID" value="AEPI004922-PA"/>
        <property type="gene ID" value="AEPI004922"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004922"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000035">
        <property type="entry name" value="Serine protease inhibitor (serpin) 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF342">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR 28DC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013289148" description="Serpin domain-containing protein" evidence="5">
        <location>
            <begin position="27"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="65"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="701"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004922-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="879" mass="98557" checksum="A3A973FB3377A7CC" modified="2017-12-20" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDL9</accession>
    <name>A0A182PDL9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDL9"/>
    <dbReference type="STRING" id="199890.A0A182PDL9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005024-RA">
        <property type="protein sequence ID" value="AEPI005024-PA"/>
        <property type="gene ID" value="AEPI005024"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005024"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000140">
        <property type="entry name" value="Coatomer subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005024-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="304" mass="34848" checksum="8CDF140EFD5A5BC4" modified="2016-09-07" version="1">MNRNNEVSELIDVENAFYIGNYQTCINECNKLSKPSLEKDIFMYRSYIAQHKYRVVLDEIKASNDTPLLALRYLAEYMSNSSRKEAIVSIFDDKFQGDINELHVIWIIVGAIIYCNEETYETAMKVLVGNFNLECLSLHMHCLLKMSRVDLAKQVASTMQEKDDDATLTQLSQAWLNIQIGGEKLQDAFFIFQDLCDKFSPTLLLLNGQAVCYIGQQKYDDAEQVLRECLNRDPNNYDTLINLLALSQQKDKNSSQFSRYIAQILDDHKGSSLVSAYNKRQAEFDRLVLQFGPSNTKPIDEIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDS4</accession>
    <name>A0A182PDS4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDS4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005079-RA">
        <property type="protein sequence ID" value="AEPI005079-PA"/>
        <property type="gene ID" value="AEPI005079"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005079"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032004">
        <property type="entry name" value="DUF4790"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16037">
        <property type="entry name" value="DUF4790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005079-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="132" mass="16121" checksum="456CDD44367CBB44" modified="2016-09-07" version="1">MDRSSSQQQRKKRRESKRKSGESKKNPKSNRSEESLHPSYTNLQPPYSAICRQRYHVNNVLYEKQFNYELKMLELMQNSAYDSMRFHRHFAITTLWPPLHTRKEIEYVLDKFFRHSERQTRRLHEIMKGPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDZ1</accession>
    <name>A0A182PDZ1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDZ1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005146-RA">
        <property type="protein sequence ID" value="AEPI005146-PA"/>
        <property type="gene ID" value="AEPI005146"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005146"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005146-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="187" mass="20643" checksum="82F5C1C848B73D65" modified="2016-09-07" version="1">MCSGATFKALCYFYAGCNMFMSISAIANANRVSQIIGYDNCTAIRPVPPDHRTDGPLETCNQYTYIFLVAASGLDCLMSLVLSLAIMLRKTLLLKVYMLHLWCHMSFCLYCWLAILFAFRGAINSSTLLSVWGVVFILASVYFAMEVWITRGAYDAVRAERAKLKQTATAVDPGPGDTLLSMGGFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEC7</accession>
    <name>A0A182PEC7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEC7"/>
    <dbReference type="STRING" id="199890.A0A182PEC7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005282-RA">
        <property type="protein sequence ID" value="AEPI005282-PA"/>
        <property type="gene ID" value="AEPI005282"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005282"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005282-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="130" mass="13485" checksum="4931D6622F449F5E" modified="2016-09-07" version="1">MHKVSSLATGTSMNQHQSDLVTSVTVSKGTAGALGTKPYVANAPHGSSTLNNNNLNSKNKNPSTQANATDSVIHMTNVSVPPKLLVPNGKSQAPAVPSAPDARAKQVLKEAVDAVVNSFAKHTQGYGREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEG6</accession>
    <name>A0A182PEG6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182PEG6"/>
    <dbReference type="STRING" id="199890.A0A182PEG6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005321-RA">
        <property type="protein sequence ID" value="AEPI005321-PA"/>
        <property type="gene ID" value="AEPI005321"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005321"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF118">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="36"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="378"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005321-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="542" mass="61736" checksum="E70B173469E10EF9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEK7</accession>
    <name>A0A182PEK7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ATG16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEK7"/>
    <dbReference type="STRING" id="199890.A0A182PEK7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005362-RA">
        <property type="protein sequence ID" value="AEPI005362-PA"/>
        <property type="gene ID" value="AEPI005362"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005362"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="6">
        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="78"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005362-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="340" mass="38167" checksum="A609FA9464092810" modified="2016-09-07" version="1">MAKMQENWRDIIADRLRERNKNESARFADIIHYNNRLFDTAAKLRQENLDLKIDKKIRDSVNVSGAGTGSTAFGTDVAAITNAQIQSLEKKVLAQQEELTDLHKRKGEHSQMVINLNQKLTDLQRLLAEKERALAEQTALALSLKEELDEMKASHVTIKDESLASQLRANTAEDKLRAVQDENTKLLNLLMEYKSRDAEIMNKENDKFVKEKKARIESELERAIRDIPGPSSIGADIDRFDVDGLPEGVEFKFDAHDGEVNAVRWSPIERIVATGGADRKVKLWDVGKGVCEQRGVLVGSNQGINSVEFDTTGSMILAASNDSASRMWSVVDHRLRVSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFG3</accession>
    <name>A0A182PFG3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidylinositol 4-kinase type 2</fullName>
            <ecNumber evidence="9">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A182PFG3"/>
    <dbReference type="STRING" id="199890.A0A182PFG3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005670-RA">
        <property type="protein sequence ID" value="AEPI005670-PA"/>
        <property type="gene ID" value="AEPI005670"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005670"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="187"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005670-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="572" mass="64061" checksum="D1C553C0D3D7AA2A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFP7</accession>
    <name>A0A182PFP7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4794 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PFP7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005754-RA">
        <property type="protein sequence ID" value="AEPI005754-PA"/>
        <property type="gene ID" value="AEPI005754"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005754"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131376" description="DUF4794 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005754-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43079" checksum="DFBF314715D2FB83" modified="2016-09-07" version="1">MQRGVIIDSSRKCRVFCYLLLLLLTCASGERFDGYVYPTPTPTPSFDGYDYTTPSCPLLDQPVVPTCTASATVLTVPVRINVTETIVTYIKQPTTVTTTLIVPTTSTEVHRAVETQTSYRTTTHTERITLPPVTKISSLTSTIARIETVTSPVVRIEYVTERYPVVEYRTDTITRTSTCTVTELFPTTYYSTYISTSYAPPITSLTYLAETSYRTLTSTLVNTQIRTQTETSAIYRTNTETVHATRTLTETTTVTAACGPPPLNNEYLPIPTPGNDYLPPLQQQQAEQRLRNNYELPEYLLPPKGPAAPLLPAETVSVTVTKTLDPVTLTKEHTVTKDAAIVTAPGAAVRTKSVIAFDQRVTKLITVTPTLTSYIYMDTVTVTSTKPQKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGB3</accession>
    <name>A0A182PGB3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGB3"/>
    <dbReference type="STRING" id="199890.A0A182PGB3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005972-RA">
        <property type="protein sequence ID" value="AEPI005972-PA"/>
        <property type="gene ID" value="AEPI005972"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005972"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF39">
        <property type="entry name" value="IONOTROPIC RECEPTOR 56A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="219"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005972-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="486" mass="55627" checksum="64069B5A9EA64262" modified="2016-09-07" version="1">MPYTNVVMALQNALGSWDMYEIFKPYRKAHLSVEGIASYYTAAVNSSVSLRKQLFLQRKNTHRRRNLQGFAMPCGTATTSPEYFRGMEDRNDVHDLFTKANFPFIRELMYDLNFTLNMVQLDKVGYKQNGTFSGVMGKFQTRSIELGCLGTLMRTERLEVADFMIVTLIIKSSIIFRQPPLSIVANIFELPFSVGVWACCFGLMAIYWVSMIAIRYLANGERFTPIESLVYIIGTMCQRGSDFVPQFNGTRLLMFSLQLTSFFILTSYSASIVALLQSPSRAIETVGDLVRSPLKAGVMDTSYGRVYYQETLDPDVQDLYRKKIKPHGEKAFMEANEGIARVEHELFAYEAEVNAAYKVIKETFAPEEVCKLQELEAIKLPPFGIPIVKGSKYRELIRQRLMWQREVGIIKRFNLIWIHQKPQCENQNAGFSSVGLVEMRYLYLFLGVGFLIALAALLAERAWWAEVTQKLKSRTAIIRRKTKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGT2</accession>
    <name>A0A182PGT2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGT2"/>
    <dbReference type="STRING" id="199890.A0A182PGT2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006141-RA">
        <property type="protein sequence ID" value="AEPI006141-PA"/>
        <property type="gene ID" value="AEPI006141"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006141"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000436">
        <property type="entry name" value="Intermediate neuroblasts defective"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF20">
        <property type="entry name" value="AGAP001560-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="189"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="250"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006141-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="334" mass="37137" checksum="EDA007D6368F0475" modified="2016-09-07" version="1">MSRSFLVDSLISDKPSTAVKKSFPYVGPFTQLPVTPPGGALPYSACYVGSYLFSLGLQQQQQQQQQQQHQLLQQHPPSVFPHAALPHTPTNQPVVPFWQSDAKLELSPKLYQPTDVSPPKLSPKEDYYRKLYRCEKTPERYAPYLTARPTESLTSAGSGAAGTSTIPAASPSPTRSNDLSQTYTIDDELSSKRIRTAFTSTQLLELEREFAGNMYLTRLRRIEIATRLRLSEKQVKIWFQNRRVKRKKGDAPFGAELTVGLSPASGRSSPKEQQQQQHGQHCCCRGSHCGGGGGSDSEDLPQRALEDRTTSPVGGQQQQQQEKAWDFSKGYPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH97</accession>
    <name>A0A182PH97_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vta1/callose synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PH97"/>
    <dbReference type="STRING" id="199890.A0A182PH97"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006306-RA">
        <property type="protein sequence ID" value="AEPI006306-PA"/>
        <property type="gene ID" value="AEPI006306"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006306"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="268"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006306-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34539" checksum="4EEA5140E913A5AB" modified="2016-09-07" version="1">MAEPNFPTLTQLLKPIQHYLKTAQEHDTRDPIVAYWCRLYALQLGLKIPNQGMEERKVLVAIMDWLETTKKQYAENESITNDVAAQAYLENYALKLFLYADKQDRASNFGKNVVKAFYTAGMIYDLCQIFGELTEEVTQNRKYAKWKASYIHNCLKNGETPVAGPMSTEEDKDYDQNEQAFQPEPQPGPSNTPSAPQPPASPQPPPPGPTNFTTTDPFSNVKAPTPPSEPEKPPGGFQPYTGGPAAGTAGQQVETNRLVSPAGVQLRPEQITKAQKYCRWAESALNYEDLKTSIENLQKALRLLQTGQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHM9</accession>
    <name>A0A182PHM9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHM9"/>
    <dbReference type="STRING" id="199890.A0A182PHM9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006438-RA">
        <property type="protein sequence ID" value="AEPI006438-PA"/>
        <property type="gene ID" value="AEPI006438"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006438"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006438-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="400" mass="45908" checksum="E079B39E5650FFF2" modified="2016-09-07" version="1">MCRTETDRLCLTKLLEAIATKDEHSLVECLRTATIDTVLCFESTYGVSPLIWCVQTGDVSYLGLVRCLLSSGFYDSMMVDSKERSVLASAADLHTDNPAFVTSLIDLEIDGVDEATACYRMLRQNSLPLLKLYLSVKQHDEAKLFESLANALIQLNVKNVSLNFSLRVFVQWMLADYGYRHLSGDYKPPPEEATHDEWKKHIDIIKYIQLEMCEMLNTVGYFGDNFHYLKHRIPMIMGKSFRNLLAHDTLSYNLLTDSGDEKLVINAFILANTKLSLFDKPTHTVPNNLCFPIPENTYQWVEEQQRLLEAFRENDVEAMSSEMKAGAEIKSLFRRSPDPHYPQASHHLVLTNLIERDYLPESAMIQLLNRYFPSFESDYRRPELRMTSMITSALLCSKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI83</accession>
    <name>A0A182PI83_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PI83"/>
    <dbReference type="STRING" id="199890.A0A182PI83"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006645-RA">
        <property type="protein sequence ID" value="AEPI006645-PA"/>
        <property type="gene ID" value="AEPI006645"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006645"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006645-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="308" mass="31565" checksum="7AA819452CB787DB" modified="2016-09-07" version="1">MPNSVSKRPGFGDDSDDERKGDGRGAGQVGMSATTKQQQPPNAAAQGKKAVGPGGKDGKTAASGAPGGSAQGSGWFGGIWNKFSLKPKNQMILPDDKNPKIVWDEVSKRWVNTDENEAEAEAYKPPPKMSDLVPGAAAGSGAPPAAPMGQSVPLMQSQDTAGPAFQQPMPNAMNQVPGRAPSQPTGAVQSNVPTAAPAAVGGGPVAGEPTKVPTLQSNMYKMQRNRTLKRSYVDVFNPSGAAPSKPTEPVLAPAVPTLPNTPGSFFVPGGVPNAVGAEQQGENVPEGMPQFYNPNQFGTGAPGGGYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIE9</accession>
    <name>A0A182PIE9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CABIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIE9"/>
    <dbReference type="STRING" id="199890.A0A182PIE9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006711-RA">
        <property type="protein sequence ID" value="AEPI006711-PA"/>
        <property type="gene ID" value="AEPI006711"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006711"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052281">
        <property type="entry name" value="GAREM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454">
        <property type="entry name" value="GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454:SF11">
        <property type="entry name" value="SERRANO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="3">
        <location>
            <begin position="226"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
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        <location>
            <begin position="691"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="703"/>
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        </location>
    </feature>
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        <location>
            <begin position="760"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="851"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006711-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="930" mass="100781" checksum="A472B7D4821D65CB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIK3</accession>
    <name>A0A182PIK3_9DIPT</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIK3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006765-RA">
        <property type="protein sequence ID" value="AEPI006765-PA"/>
        <property type="gene ID" value="AEPI006765"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006765"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="5">
        <location>
            <begin position="46"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006765-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="331" mass="36949" checksum="B06774726EDBB167" modified="2016-09-07" version="1">MSDPVSVPVGQVIPPPLIPLPSCHARAKQVQARLLNELTFPTSYIANCRLCLGTQFGSNSTTIIDEPLVSMMKRVFPFPVTNQIGLPMNVCTDCFQAVKTFVAFSDKVWEHQQKLQETLASMEYLQYHGISNNGIHQKPAEKEAQTPSISNIVIELMSGSEDEDADDSEPEMLIDADLQAKAFEDSGEQGQDPLLAPAVSKNPPLRTANRAGAIETPQKKIREEDGIIFIDCERNDSDVEEMPVIIAPSINKERLSSGSNKAQNTRKGPKPVYICSTCNETFEKHYQLMCHQKTHFMKECPLCKCSFKYSVIRDHIIKDHGVLKESNSQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIW0</accession>
    <name>A0A182PIW0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIW0"/>
    <dbReference type="STRING" id="199890.A0A182PIW0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006873-RA">
        <property type="protein sequence ID" value="AEPI006873-PA"/>
        <property type="gene ID" value="AEPI006873"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006873"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000035">
        <property type="entry name" value="Lariat debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="15">
        <location>
            <begin position="235"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="398"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="470"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="530"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="484"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006873-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="558" mass="63136" checksum="B2872D1BA145629A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJW3</accession>
    <name>A0A182PJW3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPPP family protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPPP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJW3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007229-RA">
        <property type="protein sequence ID" value="AEPI007229-PA"/>
        <property type="gene ID" value="AEPI007229"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007229"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007229-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12796" checksum="125686B5B2CC170E" modified="2016-09-07" version="1">MASNPPTGKLKAPTLPTMFTLFAKYRPTLNSFQGDGKRILLSQSDCWMQQANLIGPKHFTLTQTGLIFFEFRKSTLDYDEYIQFLTMLCNEKQVNLEEVKEKLTNCGPPGIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK54</accession>
    <name>A0A182PK54_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pumilio</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PK54"/>
    <dbReference type="STRING" id="199890.A0A182PK54"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007320-RA">
        <property type="protein sequence ID" value="AEPI007320-PA"/>
        <property type="gene ID" value="AEPI007320"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007320"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007320-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34219" checksum="8F3BC90CB3E7E039" modified="2016-09-07" version="1">MIFYRFTSLQINTSTAKKLWEKGGSNDVKVAAAATGPLPPLQLHGTTDHPVWRDSTWSSQGDAILAAPRRIFQHGPESNPTGSTGILSPRDSGGLGVKMVEYVLGGSPTNKESPLASLDSRFKGLKFDDGDKASDDKDKANSPFETNGVKKEEVVPGTNGVVMVNGIDDDKGFNRTPGSRQPSPAEEQLPRPNMLDPTGVHGSGFSQHPSLHNMLGSAAPGGNDVTQQAAATALGSYHPQMINQMGQMGQLGQMNPMNQLNQLNQLNQMQSHVMNGVGGIPQIAQSPMVNQHGQGPSQIDSPANLLQQPHNYELQVRFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKG7</accession>
    <name>A0A182PKG7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARMC9 CTLH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR91 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKG7"/>
    <dbReference type="STRING" id="199890.A0A182PKG7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007434-RA">
        <property type="protein sequence ID" value="AEPI007434-PA"/>
        <property type="gene ID" value="AEPI007434"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007434"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141039">
        <property type="term" value="F:phosphatidylinositol 3-kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056327">
        <property type="entry name" value="ARMC9_CTLH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039724">
        <property type="entry name" value="WDR91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23138">
        <property type="entry name" value="CTLH_Armc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMC9 CTLH-like" evidence="6">
        <location>
            <begin position="47"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007434-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="336" mass="37707" checksum="7F0C7EB90CABE944" modified="2016-09-07" version="1">MAHIQYIDGLIREYILFRGFSNTLKAFDNELKSDKDKSFRVDKVIEQIQLLIHNHDLGGLRELWAHLNNHLFRNLEHHFATAVNKLEQSVLKFYLIVAYTSNKMDKITEFFTKLSPELVSQSEWKEWFFFPFCKNPEEHAAFAVCFTKQWQDTLLISLHNFLSTIYQCMPQPIIAKAESEGCLIKKLQEENGLLRSKLTTIQQQQYQQLQSAGGGGGSGGHHSRLSGGSGSGADQRLTADGRIRYSTRPSSSMLSLNDLQPFGIPPPTHIVDDFYIIAQESNSIGGAAESQARGLKSLIRNIGSGGSPVLGRREAALERNKKRSGSVGSRGNWIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKM3</accession>
    <name>A0A182PKM3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKM3"/>
    <dbReference type="STRING" id="199890.A0A182PKM3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007490-RA">
        <property type="protein sequence ID" value="AEPI007490-PA"/>
        <property type="gene ID" value="AEPI007490"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007490"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF37">
        <property type="entry name" value="GH08173P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007490-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="63021" checksum="CE8CC1028D6E36F4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKR2</accession>
    <name>A0A182PKR2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP-binding protein GEM</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKR2"/>
    <dbReference type="STRING" id="199890.A0A182PKR2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007529-RA">
        <property type="protein sequence ID" value="AEPI007529-PA"/>
        <property type="gene ID" value="AEPI007529"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007529"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF1">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 3, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007529-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17034" checksum="5B6199D3CA491BF4" modified="2016-09-07" version="1">MLKADAFLVVYSVVDKATFSRADQLLNMLHDMDVSRSRPTILVANKIDLARSRAVSSQDGKCLACTHKIKFIEVSVAINHNVDELLAGILSQIRLKREQSAVQGVREPSSSAHWYKNRSVVRASMKARQMITWIFGKEDSKFKNCENLQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKU2</accession>
    <name>A0A182PKU2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diaphanous</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKU2"/>
    <dbReference type="STRING" id="199890.A0A182PKU2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007559-RA">
        <property type="protein sequence ID" value="AEPI007559-PA"/>
        <property type="gene ID" value="AEPI007559"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007559"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010465">
        <property type="entry name" value="Drf_DAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06345">
        <property type="entry name" value="Drf_DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="6">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="7">
        <location>
            <begin position="516"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="5">
        <location>
            <begin position="936"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="902"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="953"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="978"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007559-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1005" mass="113028" checksum="48C638ECA326A80A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL03</accession>
    <name>A0A182PL03_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PL03"/>
    <dbReference type="STRING" id="199890.A0A182PL03"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007620-RA">
        <property type="protein sequence ID" value="AEPI007620-PA"/>
        <property type="gene ID" value="AEPI007620"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007620"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007620-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="45181" checksum="3B1318FF3DDFE4B8" modified="2016-09-07" version="1">MNDKKNKLKNNASKVNDNPLNCHLSKVDTSDTYLLKIKTWSPGKRSQCFVTLYRHSKSNISTIQRNSNSLRTRLSCSHNSLTDSIKNKADDSVFITQAMSHDALDDNKILDFYNVPIDSDIYTTPIDLIRNTYNAETSFYRNRNEASQRNSWNNLLNYSEQISSIHERKHIKPHIIFDRKSTKAIDKHASDKADGKRNSISQELRSQCKKSNFSINLKQKFCNIFRVSRQQHHKPFLSNKRSIVSSRTKDSAVCVKDKNESAIIKKLTTSRKLPPLPANESDLRYLMGDTSDQKKRSNERKSSMDFTARSFSFGSCAKFKSRTIMEFIENAVEHSRSGRFIIHKTIKRKDLIQTLPLPRRVLDYLCYKNCLSERTEVDSLSSLEKPNIVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLR9</accession>
    <name>A0A182PLR9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLR9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007891-RA">
        <property type="protein sequence ID" value="AEPI007891-PA"/>
        <property type="gene ID" value="AEPI007891"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007891"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974:SF2">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007891-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="433" mass="48477" checksum="E1C9A3B4322D02B2" modified="2016-09-07" version="1">MVDPRALLANIQRRLTARTTNRWRTVMIPGVMGCSSSVVLEEAVPTHPPTPVLDPDEQQRLPAFVPKHSESLAEAYRRLDEEICALESTTPGPRLMTAEAWVELLQSAKGPAGIELEQERAVPAPLPNEVLPNGTIPNGVPGGAVKQPIPTEKDRQAESARTEMVKIILKLDIVSNEFKAAQQEEFIARLSRTAMDQEADHFREEMIVHARKRALALRTNFERLKRLYIEQDHMLTSVYNGAYGTVKEQNLDAELDAARDVRDRLGGAVEQWRIAGGLLRAAAKGLHQVVEYWELIRPSKGAEETITLALDARSTCHGALMALEAAQAALPSVEIPYITIRQQSAVRHALIYLLTDMVNPARYQHTRDVFGVFSANISKAVHWLHECYSETLKQDFDSPDQVATLLAKNLREERLRFIVNRMPNKIYVRPAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLY3</accession>
    <name>A0A182PLY3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLY3"/>
    <dbReference type="STRING" id="199890.A0A182PLY3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007955-RA">
        <property type="protein sequence ID" value="AEPI007955-PA"/>
        <property type="gene ID" value="AEPI007955"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007955"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000770">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="15">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="407"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="430"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007955-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="62704" checksum="128DC92075A15B45" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM03</accession>
    <name>A0A182PM03_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PM03"/>
    <dbReference type="STRING" id="199890.A0A182PM03"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007975-RA">
        <property type="protein sequence ID" value="AEPI007975-PA"/>
        <property type="gene ID" value="AEPI007975"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007975"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000001">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000047">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007975-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="423" mass="49517" checksum="42AAC40ED54C0C88" modified="2016-09-07" version="1">MVGLPARGKTYISKKLSRYLNWIGINTKVFNLGEYRRHATDAYRSHEFFRPDNEEAMAIRQHCAELALEDVCNWLEKSGEVAVFDATNSTRDRRQMIREIVVKKMGYKLFFVESICDDPSIIEQNIMEVKVSSPDYRNMNMDEALSDFRLRIEHYQERYEPLSEELEKDLSYMKIYNTGEKVVVHKHEGHIQSRIVYYLMNIHITPRTIYLTRHGESEHNLQGLIGGDSNLSERGRRYAQALAKYIDEQQIEGLRVWTSWLKRTIQTVADVNAPQERWKALNEIDAGICEEMTYEDIQQRFPEEFKARDQNKFAYRYPRGESYEDLVVRLEPVMMELERQGNVLVVSHQAVLRCVLAYFLDKSADELPYLKVPLHTIIKLTPVAYGCKVEHIMLPIHAVDTHRAKPEVSACFIPVHSFNRTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM10</accession>
    <name>A0A182PM10_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PM10"/>
    <dbReference type="STRING" id="199890.A0A182PM10"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007982-RA">
        <property type="protein sequence ID" value="AEPI007982-PA"/>
        <property type="gene ID" value="AEPI007982"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007982"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF494">
        <property type="entry name" value="GH04538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="720"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="750"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="837"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="863"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="902"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="53"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="165"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="524"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007982-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="932" mass="102783" checksum="30CDCC268BC7819A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMW3</accession>
    <name>A0A182PMW3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alpha-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19254"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="6"/>
    <dbReference type="STRING" id="199890.A0A182PMW3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008287-RA">
        <property type="protein sequence ID" value="AEPI008287-PA"/>
        <property type="gene ID" value="AEPI008287"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008287"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061750">
        <property type="term" value="F:acid sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11328">
        <property type="entry name" value="AmyAc_maltase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
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        <property type="entry name" value="Sphingomyelin phosphodiesterase"/>
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        <property type="entry name" value="Sphingomyelin phosphodiesterase"/>
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    </dbReference>
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        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Saposin B-type" evidence="17">
        <location>
            <begin position="207"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008287-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1308" mass="150204" checksum="F2E3286A255B893E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNB5</accession>
    <name>A0A182PNB5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNB5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008442-RA">
        <property type="protein sequence ID" value="AEPI008442-PA"/>
        <property type="gene ID" value="AEPI008442"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008442"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008442-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="264" mass="29421" checksum="630E14DA029AB71B" modified="2016-09-07" version="1">MTDRPVSRLAISDPTVCYHDPNHPGPGHYDPEKPQQSRFHEKANKKPSSHLPCCYTYGQYCSEPFFRPPPGRYDLRDAQASSFGSQTRCAHQYGTVTIRLNSIDIPVRPRKGRRNMKVAFLSGSARWKDRDFFPIGGLGKATAGTRCKRSGPKQPMEHVTTSNESLSLQRGSQTSPPRIMRNGTERETEREPSPGSGSPRTSPAMNGQLEAEEEKVEGEEVNGKRVSADLVQLLVAHGITRGELPPLSKNKIPTKFFTVPRLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNG2</accession>
    <name>A0A182PNG2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNG2"/>
    <dbReference type="STRING" id="199890.A0A182PNG2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008489-RA">
        <property type="protein sequence ID" value="AEPI008489-PA"/>
        <property type="gene ID" value="AEPI008489"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008489"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF352">
        <property type="entry name" value="BCDNA.GH04802-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="207"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008489-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="319" mass="36354" checksum="29931B5AC46EA5DB" modified="2016-09-07" version="1">MERKRSIRRRQKPPFAERAKDHCRNFTAFMFSNVGIIFLVVLYMIAGAFMFIAIEGNEALERFAQIPFKRNETAMKLWQISCCEVNVFNKSVFEEKVGNEIRAYQEKIVLWARRGWQGSDITLESETPWSFSGAFLYSLTVITTIGDILAKSFKWIYAKFCLCRSEMGDNGFDTNTITTSNVDEEIEEEITAETNTVTVPITICIMIMIGYIFFGARLFADWENWDILDGSYFCFISLSSIGFGDIVPGASLQTKGDTKMEISFILCAVYLLLGMALIAMCFNLMQEQVIYKIRSLKKCVRGCFHCAKAVPVPIDESET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNP7</accession>
    <name>A0A182PNP7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNP7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008574-RA">
        <property type="protein sequence ID" value="AEPI008574-PA"/>
        <property type="gene ID" value="AEPI008574"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008574"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008574-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="387" mass="44838" checksum="562D7B32DBBBD3B4" modified="2016-09-07" version="1">MLALQSHRAFLARLRWALRAQHVFGVSSLVVDKQGHVTSGSSAPKYIWMLMVLFILMAVWFVHYNNETPIVCKSNASKVKLFYYFVILETMIAIVFKLVLTIKIAWPASQQSLAQCWSQLIAKVHEFQVSYHCNIESKREFQLFWLWLTVLLAVYGFLLTFMVATSKVLFMVQTNHYIIYGLRIYAYLSDTTVCASFGLFALLLKALIEEMRKMVRQSNISENQLRSMIQLYRHILQIIESLCAVYGWVLIMILFEHFLIITDRSFFAIRMYRRPMGFTLSQVISMMMTWVFPLALNDTLLVGSCTATEKALKEFEQELCELGKMANVNKVEHEYMITCFSLYVAEQKPKFRILKSLNLNFNVIYAACGVIATYLTVFLQFDNGDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP64</accession>
    <name>A0A182PP64_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP64"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008743-RA">
        <property type="protein sequence ID" value="AEPI008743-PA"/>
        <property type="gene ID" value="AEPI008743"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008743"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF37">
        <property type="entry name" value="INNEXIN INX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008743-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="393" mass="44586" checksum="C87A57C854A70EF6" modified="2016-09-07" version="1">MAVFGLVSAVAGFVKVRYLQDKAIIDNMVFRCHYRITSAILFACCIIVTANNLIGDPISCINDGAVPGHVINTYCWITYTFTLPGQHGRAMGTEVAHSGLGNDNQERTYHSYYQWVPFMLFFQGLLFYVPHWIWKNWEEGRMRMITEGMRGVSTASPAERKARHERLAQYLYDSVNTHNTYSFGYFICEALNFVNVVGNIFFVDKFLGGAFLTYGSDVLRFSNMNQENRSDPMIEIFPRVTKCTFHKYGSSGSIQKHDALCVLALNILNEKIYIFLWFWFIALAVASGLAIIYSAAIVMMPTTREAVLKRRFRKANPGEVCNLIRRVQIGDFLMIHLLGQNLNVTSYGEMLQTFINMLDEGRPISGDTPSAPSTLEMAPMYPAIEKYGKETET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP95</accession>
    <name>A0A182PP95_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP95"/>
    <dbReference type="STRING" id="199890.A0A182PP95"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008774-RA">
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        <property type="gene ID" value="AEPI008774"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008774"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17384">
        <property type="entry name" value="MFS_SLC18A1_2_VAT1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000792">
        <property type="entry name" value="Synaptic vesicle amine transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000401">
        <property type="entry name" value="Vesicular amine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="42"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="426"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
            <begin position="462"/>
            <end position="477"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008774-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="490" mass="51925" checksum="094266CE8501D103" modified="2016-09-07" version="1">MAQLCLSVPIIPEFLYDIRHPDAPLASFPKTPPTTPCEKEVTTPYNGIDVTTQGYDNASWYAEREERHKELVEETVEVGLMFASKAFVQLLANPIVGPLTHKIGYSIPMFAGFVIMFISTLIFAFGRTYSVLFLARALQGIGSSCSSVSGMGMLADRYTDDKERGNAMGIALGGLALGVLIGPPFGGIMYEFVGKSAPFLILSALALGDGLLQLIMLQPSVVIEESDPPSLKALVTDPYIIIAAGAITFANMGIAMLEPSLPIWMMDNMGASRWEQGVTFLPASISYLIGTNLFGPLGHRIGRWLAALLGLVIIGLCLLCIPMATSINHLILPNAGLGFAIGMVDSCMMPELGYLVDIRHSAVYGSVYAIGDVAFCLGFAIGPALSGTLVNTIGFEWMLVGISILCFAYAPLMTFLRAPPTKEEKKVSSNGIDNAGLSLESGPCGTSSTDPAPSSPEKAPSNGRVTNGTGYTNGTDGPSPNGGENFVTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPW0</accession>
    <name>A0A182PPW0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPW0"/>
    <dbReference type="STRING" id="199890.A0A182PPW0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008990-RA">
        <property type="protein sequence ID" value="AEPI008990-PA"/>
        <property type="gene ID" value="AEPI008990"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008990"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000176">
        <property type="entry name" value="Potassium channel subfamily K member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF87">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="127"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="233"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008990-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="349" mass="39377" checksum="733F1CA53185DB6A" modified="2016-09-07" version="1">MIRQRSSVRSRGSSSTTISDPREKVKDCCRKFVAFMCTQVGVGGLIVAYALVGAASFMSIETQEPNPLIEHVVTLRRNCAAELWDVTEQLNLFNSSIWHYEADLVLKRYQDDFAEAIRRGYDGRSPEEVWNFPAALMFCLAVFTMIGYGNMVPRTAWGKGATVIYATFGIPLYILYFMNMGKVLASTFKWLYTWFHECSHRSDEDGGLALEEGPGGLAPRKRIIVPTTACLWVITIYIATGTIMFAEWEKWTYLDSAYFCVTSLCKIGIGDLVPGANILDSQSGKPTKLVINFVYMLLGMGLVAMCYILMREEVRIKMQEIKEDTRLCLEDLSSKFAKCCGTKDSQYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ53</accession>
    <name>A0A182PQ53_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQ53"/>
    <dbReference type="STRING" id="199890.A0A182PQ53"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009083-RA">
        <property type="protein sequence ID" value="AEPI009083-PA"/>
        <property type="gene ID" value="AEPI009083"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009083"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20065">
        <property type="entry name" value="FH_FOXP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000010">
        <property type="entry name" value="Forkhead box P2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047412">
        <property type="entry name" value="FH_FOXP1_P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032354">
        <property type="entry name" value="FOXP-CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF4">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16159">
        <property type="entry name" value="FOXP-CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="13">
        <location>
            <begin position="257"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="11">
        <location>
            <begin position="257"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="347"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="475"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009083-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="573" mass="62631" checksum="72604BB7BA747821" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQL9</accession>
    <name>A0A182PQL9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQL9"/>
    <dbReference type="STRING" id="199890.A0A182PQL9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009250-RA">
        <property type="protein sequence ID" value="AEPI009250-PA"/>
        <property type="gene ID" value="AEPI009250"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009250"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009250-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="208" mass="21440" checksum="29451FB2C0FC0736" modified="2016-09-07" version="1">MMSKLAMIDADTGTGDVGGPGVVGTGGAVTAPTVAATGGQDGTGDPDSNSPRTEPKKKESSRKWKNWGWKTNTAAGTAPNAANGAAGQKQASIEEEADSPKRSGGSTRHSSPADSPKHKLLLGTGKVEDVNSNASISPASLRRKKFLSSKNQSPVNRSEARASAGARLYEELESSLQDSDSDELAALIVNGRPATIHLIQTSTIPGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQU6</accession>
    <name>A0A182PQU6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQU6"/>
    <dbReference type="STRING" id="199890.A0A182PQU6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009327-RA">
        <property type="protein sequence ID" value="AEPI009327-PA"/>
        <property type="gene ID" value="AEPI009327"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009327"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00916">
        <property type="entry name" value="Npc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033916">
        <property type="entry name" value="ML_Npc2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF36">
        <property type="entry name" value="NIEMANN-PICK TYPE C-2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131757" description="MD-2-related lipid-recognition domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="7">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="7">
        <location>
            <begin position="214"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009327-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="345" mass="35574" checksum="FCC9C939A73602E3" modified="2016-09-07" version="1">MYKVLLIVAILPAIAFGQTPFRPCRGGGPTPDSVSIEGCTELPCTIVSGSPLIARATGIRTPVATATVEAHITARVLGLDVGFRIPEDLADACAVGITGATCPLAAGQQFDYTLNYAMTLPLTGITAQVEVGLTAADGSTITCIEIDAQIVSEEEQNYEPNMVTFPGARYLRSATDLGQSSQILDVSLVPLATMYKFLLIAALLPAVVFGQTPFRPCSNGQPTPASLNIEGCTALPCTITSGAPLVARGIGIVSPVATPTLTADLTARLLGLDVGFEIPEELRDACAVGISGASCPIAAGQTFDYELNYAMELPLVGITVQVEVGLTAADGTAVTCIEIDATIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR28</accession>
    <name>A0A182PR28_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182PR28"/>
    <dbReference type="STRING" id="199890.A0A182PR28"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009409-RA">
        <property type="protein sequence ID" value="AEPI009409-PA"/>
        <property type="gene ID" value="AEPI009409"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009409"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000032">
        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="66"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009409-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="499" mass="54710" checksum="7DCA33F66F7F2881" modified="2016-09-07" version="1">MDTIYTSERIYPNSALLPAEVFAGGIVVSAIDGKVTRVLRSRAAVERYLQDSAGEVEHVDFGDLLLMPGLVDTHVHINEPGRTDWEGFHTATKAAAAGGFTTVCDMPLNSIPPTTSVHNLRAKVGAARGKIFVDVAFWGGLVPGNEAELRPLIDAGVIGFKCFLCPSGVDEFPHVTERQVQRAARLLEGTGAVLAFHAELECQRGRTDATEPYRYRTFLATRPAIMERRAIELVANVAQQYDVRAHIVHLSTAQALPTIREARARGARLTVETCHHYLALAAEDVPDARTEYKCCPPIRDRTNREQLWRALQSGDIDLVVSDHSPSPPQLKLLTDGKRRGNFLEAWGGIASLQLGLPLFWTGGQRYGMTVRETLRLLCTEPARLAGLQHRKGRLDVGYDGDMCVWDPEGVFTVTTDMLEFQHKATPYLNRTLRGVVHATVLRGTIVYRRTGAAPFGPPMGSVLLDGNSGNRDEDPKVSGHSKLTADNTSGEDFEDGVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR48</accession>
    <name>A0A182PR48_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycoside hydrolase family 31 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PR48"/>
    <dbReference type="STRING" id="199890.A0A182PR48"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009429-RA">
        <property type="protein sequence ID" value="AEPI009429-PA"/>
        <property type="gene ID" value="AEPI009429"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009429"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06592">
        <property type="entry name" value="GH31_NET37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SITS-BINDING PROTEIN"/>
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        <property type="entry name" value="Glycosyl hydrolase domain"/>
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        <location>
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        </location>
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        <source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21365"/>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
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    <sequence length="961" mass="108806" checksum="B1A646C093B5A1D9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR54</accession>
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        <recommendedName>
            <fullName evidence="11">Gustatory receptor</fullName>
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    </protein>
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        <lineage>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">Epiroticus2</strain>
        </source>
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009435-PA"/>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">Protein tincar</fullName>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
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    <dbReference type="AlphaFoldDB" id="A0A182PSK8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009943-RA">
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        <property type="gene ID" value="AEPI009943"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI009943"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579:SF20">
        <property type="entry name" value="PROTEIN TINCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="928"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009943-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1173" mass="126088" checksum="5B20555A41307206" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTE6</accession>
    <name>A0A182PTE6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transgelin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTE6"/>
    <dbReference type="STRING" id="199890.A0A182PTE6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010232-RA">
        <property type="protein sequence ID" value="AEPI010232-PA"/>
        <property type="gene ID" value="AEPI010232"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010232"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21207">
        <property type="entry name" value="CH_dMP20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF13">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010232-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="174" mass="19495" checksum="2126FFED2727D9C9" modified="2016-09-07" version="1">VAGKRDRDQEREAQHWIETVIGEKFPAGYVYEDCLRDGILLCRLMNRLSPGIVPKINTTGGDYKMMDNINQFQKACIKYGVADVDLFQTTDLWDRKNIALVTTTIFAVGRACYKHPEFRGPYLGPRPAEENRREFTEEQLRAGEGLIGLQAGSNKGATQAGLNFGATRKILLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU72</accession>
    <name>A0A182PU72_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PU72"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010508-RA">
        <property type="protein sequence ID" value="AEPI010508-PA"/>
        <property type="gene ID" value="AEPI010508"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010508"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010508-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="280" mass="31434" checksum="C51E2C1421914244" modified="2016-09-07" version="1">MEIVIVPCYRFRQQSCDKLLRDLHENNLDVASIVTTAATGSAMAAMVTANGATCEPQQQHDQLSIEPCPSTSTGKGQQSPQPQIVVGTIELNNLNGESASSNKQEKEIAASNQFETLALIDEDDEEEKDRNCSNAHSSSSLLSSNNDNRSTEENNVHNATTLSIAEQHRRRQRRRSSQKDRRSAEDIDSIDQADSAVDVTHEEEEPNVFDDEEDEKKTDSANSVAALRRRKNKRQRSRQRRSPALVHRDMVDGEEQQKEPYDKAVTCLYWSLACWDCNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU76</accession>
    <name>A0A182PU76_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PU76"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010512-RA">
        <property type="protein sequence ID" value="AEPI010512-PA"/>
        <property type="gene ID" value="AEPI010512"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010512"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18490">
        <property type="entry name" value="BACK_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18286">
        <property type="entry name" value="BTB2_POZ_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043225">
        <property type="entry name" value="BACK_BTBD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427:SF7">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26017">
        <property type="entry name" value="BACK_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="1320"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
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            <dbReference type="PROSITE" id="PS50097"/>
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            <dbReference type="EnsemblMetazoa" id="AEPI010512-PA"/>
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            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2279" mass="245602" checksum="C7B2CDAFD3CB1C6F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUA3</accession>
    <name>A0A182PUA3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tetratricopeptide repeat protein 21B</fullName>
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    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
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        <property type="term" value="C:cilium"/>
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        <property type="term" value="P:intraciliary retrograde transport"/>
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        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="TPR Domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="ARM_TT21_2nd"/>
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        <property type="entry name" value="TTC21A/TTC21B"/>
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        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21 HOMOLOG"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="15"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B N-terminal ARM repeat" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
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    </feature>
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    </feature>
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    </feature>
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    </feature>
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            <end position="1090"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010539-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1337" mass="151807" checksum="8B4946D2E3E2F417" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUC2</accession>
    <name>A0A182PUC2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transport protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUC2"/>
    <dbReference type="STRING" id="199890.A0A182PUC2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010558-RA">
        <property type="protein sequence ID" value="AEPI010558-PA"/>
        <property type="gene ID" value="AEPI010558"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010558"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="42"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="141"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="237"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010558-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="328" mass="35403" checksum="F861FE595EECE279" modified="2016-09-07" version="1">MDRLGLLMAYGQPNKHSSQFRNPFGGRPWMEQSGAAAAAPGAKGLKGIVAGGITGGIEICITFPTEYVKTQLQLDEKGATKQYNGIMDCVKKTVKTNGVLGLYRGLSVLLYGSIPKSAVRFGAFESLKGRLMDTNGQLSTSGKLLAGLGAGVAEAILAVTPMETVKVKFINDQRSATPKYKGFFHGVGMIVRQEGLSGVYKGLTATILKQGSNQAIRFYVMETLKDMYKGDDPSKPVPKMVVGAFGAVAGAASVFGNTPIDVVKTRMQGLEAAKYKNTADCALQIWKNEGPMAFYKGTVPRLSRVCLDVAITFMIYDSFMDLFNKFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVV7</accession>
    <name>A0A182PVV7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVV7"/>
    <dbReference type="STRING" id="199890.A0A182PVV7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011094-RA">
        <property type="protein sequence ID" value="AEPI011094-PA"/>
        <property type="gene ID" value="AEPI011094"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011094"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000001">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="13">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011094-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="116" mass="13474" checksum="3DA0D2DB9291FED0" modified="2016-09-07" version="1">MAFESIPKDLRALRACLVCSMVKSFDQFETDGCDNCEDFLRMKNNREQVYDCTSNNFDGMIAVMSPDDSWVCKWQRISRFTKGIYAISVSGRLPNSIIREMKNRGIPYRPRDTSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVX0</accession>
    <name>A0A182PVX0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVX0"/>
    <dbReference type="STRING" id="199890.A0A182PVX0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011107-RA">
        <property type="protein sequence ID" value="AEPI011107-PA"/>
        <property type="gene ID" value="AEPI011107"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011107"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd02643">
        <property type="entry name" value="R3H_NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034076">
        <property type="entry name" value="R3H_NF-X1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="261"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="264"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="14">
        <location>
            <begin position="888"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="83"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011107-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="998" mass="110183" checksum="24FFE2A5BC7637A8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVX9</accession>
    <name>A0A182PVX9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ufm1-specific protease 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C78 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVX9"/>
    <dbReference type="STRING" id="199890.A0A182PVX9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011116-RA">
        <property type="protein sequence ID" value="AEPI011116-PA"/>
        <property type="gene ID" value="AEPI011116"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011116"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071567">
        <property type="term" value="F:deUFMylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049387">
        <property type="entry name" value="UFSP2-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058757">
        <property type="entry name" value="UFSP2_MPN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF2">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26560">
        <property type="entry name" value="UFSP2_MPN_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20908">
        <property type="entry name" value="UfSP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UFSP2 N-terminal MPN-like" evidence="8">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="UFSP2 second" evidence="7">
        <location>
            <begin position="157"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="6">
        <location>
            <begin position="404"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011116-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="66105" checksum="D372AE1B801405C3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVZ7</accession>
    <name>A0A182PVZ7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Breakpoint cluster region protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVZ7"/>
    <dbReference type="STRING" id="199890.A0A182PVZ7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011134-RA">
        <property type="protein sequence ID" value="AEPI011134-PA"/>
        <property type="gene ID" value="AEPI011134"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011134"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13368">
        <property type="entry name" value="PH_BCR_arthropod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000004">
        <property type="entry name" value="active breakpoint cluster region-related protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037769">
        <property type="entry name" value="Abr/Bcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23182">
        <property type="entry name" value="BREAKPOINT CLUSTER REGION PROTEIN BCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23182:SF1">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19057">
        <property type="entry name" value="PH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="DH" evidence="10">
        <location>
            <begin position="386"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="598"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="787"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="11">
        <location>
            <begin position="936"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011134-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1139" mass="125695" checksum="C91E283BB269AE97" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWH2</accession>
    <name>A0A182PWH2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWH2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011309-RA">
        <property type="protein sequence ID" value="AEPI011309-PA"/>
        <property type="gene ID" value="AEPI011309"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011309"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="1">
        <location>
            <begin position="43"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011309-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="130" mass="14656" checksum="2EDF6C5984F9D1F6" modified="2016-09-07" version="1">INGKQINSAAKCSNLCRCRELALQNSKQIFTLCKLVITKCNANIDELQDLEESLTLALHSTQIKERLIKEIKASSAKQHMHEAVYLLFNRLFLTECCWSCRGGKIAFKNYTNILRLIKCVGGEGNTEAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWI4</accession>
    <name>A0A182PWI4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWI4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011321-RA">
        <property type="protein sequence ID" value="AEPI011321-PA"/>
        <property type="gene ID" value="AEPI011321"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011321"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011321-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="71" mass="8070" checksum="8CDD7156A8F6E395" modified="2016-09-07" version="1">MQIKFQFEINYLTLVECDAVECSGQTLVRQVITEDCGQEELVQCTRPLQVLSATSELSFVTKKEELDKLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWX3</accession>
    <name>A0A182PWX3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWX3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011460-RA">
        <property type="protein sequence ID" value="AEPI011460-PA"/>
        <property type="gene ID" value="AEPI011460"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011460"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131881" evidence="1">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011460-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="75" mass="8555" checksum="6ED6E6D565E1FFEE" modified="2016-09-07" version="1">MKTIVAFALFIACVAQIQCVSYKSCGENLYYTEEFPRGYQVEVAYNPYPYRHAGLLHGYGSDCDCPRCSPRLFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX32</accession>
    <name>A0A182PX32_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1731 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX32"/>
    <dbReference type="STRING" id="199890.A0A182PX32"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011519-RA">
        <property type="protein sequence ID" value="AEPI011519-PA"/>
        <property type="gene ID" value="AEPI011519"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011519"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05242">
        <property type="entry name" value="SDR_a8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11092:SF0">
        <property type="entry name" value="EPIMERASE FAMILY PROTEIN SDR39U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11092">
        <property type="entry name" value="SUGAR NUCLEOTIDE EPIMERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="2">
        <location>
            <begin position="246"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011519-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32531" checksum="0E47109FAA2E9198" modified="2016-09-07" version="1">MSHVVVGGGTGFIGRRLVKSLLAEGYAVTTISRMPGPKHISWHELEKHGLPNGTSAVVNLAGQNVLDPTRRWTPGFKQNVWNSRINTTAACARAIERATVKPSVFVNISGVSHYAPGSQKHTELSKVTEYDFMSRLCVEWERAATLSDNSICRVVRLRSGVVLGREGGMIQSLILPFWFGFGGPVGDGSHDLPWIHVADLCGLIRFAIERPEVSGVLNGVAPELATNADFTKAFASALVRPAFFPMPLFALNLIFAEERAVLLTNGAKVVPQRVLEYGYQYRYPDLQSACKEVAHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PXM6</accession>
    <name>A0A182PXM6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PXM6"/>
    <dbReference type="STRING" id="199890.A0A182PXM6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014111-RA">
        <property type="protein sequence ID" value="AEPI014111-PA"/>
        <property type="gene ID" value="AEPI014111"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014111"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131982" evidence="2">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014111-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="264" mass="26754" checksum="0CF41A5F453C66A8" modified="2016-09-07" version="1">MELLRAVALVVTLLAVGMVTGVPVDEGRDDTTTTDAITTTAEQTTTTAEETTTTAEQTTTTTAPTTTTVEDTTTTTAPATTTVEDTTTTTAPTTTTTEQTTTTAEQTTTTTAPTTTTVDDTTTTTAPTTTTVEDTTTTTAPTTTTAEQTTTTTVATTTINPEQTTTTTEATTTTTQVTTTTTPASTTSAEQTTTTTEPASTTTVPQTTTTTASAPTTTTDAPITDAPTTTTIEPETTTQGASSIASFGAALLTAVALANALRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ52</accession>
    <name>A0A182PZ52_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZ52"/>
    <dbReference type="STRING" id="199890.A0A182PZ52"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015117-RA">
        <property type="protein sequence ID" value="AEPI015117-PA"/>
        <property type="gene ID" value="AEPI015117"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015117"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015117-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="386" mass="44008" checksum="5F33FB53FD9293AC" modified="2016-09-07" version="1">MSKFFTIEKPPGVPHIALKLLRMVGVSQLKSERYRYVVVFGVFLLTIAVPKVVLGYTSFEASIVGLAELFFQTNRFVGVLLLVLYSDTLFALVRKSENFTKKVLCETSPVSRYLKTADAQFTKLTRLYLTALLVPANFYSYSPIVSTLWRYYHAHENDTAPEFVLPMEENFYGLQVREKLSHYLIFGTVMVPTSFLCALVGTAKLVSILSLLKYCTMYFQLITVKLKTIVHGQDNRHKLRCALEMHQSVLECADLLKTITAPIMLLQLVLCILVWSSMLLYFTISGFNTQFISVFILFLFDTTETFGYCYLGNQLSDESARIASVVYECGWEGFSSAVQKDLQLTLLRAQRPVGITAGKFCFMNMEQFGEVVKTTYSFFIVLREQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PK92</accession>
    <name>A0A240PK92_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PK92"/>
    <dbReference type="STRING" id="199890.A0A240PK92"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015317-RA">
        <property type="protein sequence ID" value="AEPI015317-PA"/>
        <property type="gene ID" value="AEPI015317"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015317"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="196"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015317-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="416" mass="46864" checksum="257A72D83FD1E145" modified="2017-10-25" version="1">METLIKEMENQRTEEVFWRTTLMDTQIKMMNHHMARINYDVKTMQVKIKDNKDKIKMYKTRPHLVATVMEVLDMKLDEEEEENDGAAMAIESQRKGRCAIIKASTRQTIFLPEIGLVEAEELKPGDFVAVNKDSFLILDELAPDRDPRVKAMEVDERPTEQYTDIGGLDKQIQELVEAIVLPLTHKNKFEKMGIQPPKGVLLYGSPGTGKTLLARACAAQTKSTFLKLAGTQLVQMFIGDGAKLVRDAFALAKEKSPTIIFIDEVDAIGMKRFDSEKEGDREVQRTMLELLNQLDGFSSSADIKVIAATNRVDILDPALLRSGRLDRKIEFPHPNEEARARIMQIHSRKMSVSPEVNFEELARSTDGFNGAQCKAVCIEAGMIALRRSAESVMHEDFMEAIVEVQSKKKSGLDYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PNB0</accession>
    <name>A0A240PNB0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Luciferin 4-monooxygenase</fullName>
            <ecNumber evidence="4">1.13.12.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>firefly D-luciferin + ATP + O2 = firefly oxyluciferin + hnu + AMP + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10732"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16792"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58038"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.13.12.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.7" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A240PNB0"/>
    <dbReference type="STRING" id="199890.A0A240PNB0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015278-RA">
        <property type="protein sequence ID" value="AEPI015278-PA"/>
        <property type="gene ID" value="AEPI015278"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015278"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF423">
        <property type="entry name" value="GM05240P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0455">Luminescence</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-0599">Photoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="14">
        <location>
            <begin position="37"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="15">
        <location>
            <begin position="448"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015278-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="540" mass="58883" checksum="1FD982294AA1B8C1" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZH3</accession>
    <name>A0A182NZH3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable nuclear hormone receptor HR3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear receptor subfamily 1 group F member 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Putative receptor whose ligand is not yet known.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZH3"/>
    <dbReference type="STRING" id="199890.A0A182NZH3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000053-RA">
        <property type="protein sequence ID" value="AEPI000053-PA"/>
        <property type="gene ID" value="AEPI000053"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000053"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06968">
        <property type="entry name" value="NR_DBD_ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000003">
        <property type="entry name" value="Nuclear orphan receptor ROR-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044101">
        <property type="entry name" value="NR_DBD_ROR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF2">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="14">
        <location>
            <begin position="249"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="204"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000053-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="322" mass="32865" checksum="B9693E21C1B4296C" modified="2016-09-07" version="1">MDDGEFLDLFSQSWNGKYHAAASRAANDEPASVGTGGYPNTAAVAAAATAAATAAAMAVAPKLTSRLMQPQPGSTAGPGAQGLYASTKHFLAHLPPTHKPQPATNTTSTAAAATATEAARHSSPSPFTPPPASGPGSAGQSAMLRGGQEEQDYNAFCSTLSAVASMAQASLAMEEEDLADSTTPPPQPFTAGGLLAAGLAGNGGGGGSAGDANGGGVEGDLGPNGELLGMNGHQHEKKTPNSIRAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZI8</accession>
    <name>A0A182NZI8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Histone-lysine N-methyltransferase 2C</fullName>
        </recommendedName>
    </protein>
    <organism evidence="32 33">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="32">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Component of the MLL3 complex (also named ASCOM complex), at least composed of catalytic subunit KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Forms a core complex with the evolutionary conserved subcomplex WRAD composed of WDR5, RBBP5, ASH2L/ASH2 and DPY30 subunits; WRAD differentially stimulates the methyltransferase activity. Interacts (via WIN motif) with WDR5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182NZI8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000069-RA">
        <property type="protein sequence ID" value="AEPI000069-PA"/>
        <property type="gene ID" value="AEPI000069"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000069"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098687">
        <property type="term" value="C:chromosomal region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15665">
        <property type="entry name" value="ePHD1_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15666">
        <property type="entry name" value="ePHD2_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21997">
        <property type="entry name" value="HMG_KMT2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15509">
        <property type="entry name" value="PHD1_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15510">
        <property type="entry name" value="PHD2_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15512">
        <property type="entry name" value="PHD4_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15513">
        <property type="entry name" value="PHD5_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15514">
        <property type="entry name" value="PHD6_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19171">
        <property type="entry name" value="SET_KMT2C_2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000009">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000003">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.360:FF:000001">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000852">
        <property type="entry name" value="Histone-lysine N-methyltransferase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000407">
        <property type="entry name" value="Histone-lysine N-methyltransferase MLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000548">
        <property type="entry name" value="Putative Histone-lysine N-methyltransferase MLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF6">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
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            <end position="6054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="6055"/>
            <end position="6064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="6068"/>
            <end position="6090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="6099"/>
            <end position="6115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="6125"/>
            <end position="6138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="6398"/>
            <end position="6411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="6636"/>
            <end position="6649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="6657"/>
            <end position="6666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00058707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00065668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00072631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000069-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="7237" mass="774935" checksum="726F54BE5AE42F1B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P044</accession>
    <name>A0A182P044_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arb2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P044"/>
    <dbReference type="STRING" id="199890.A0A182P044"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000276-RA">
        <property type="protein sequence ID" value="AEPI000276-PA"/>
        <property type="gene ID" value="AEPI000276"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000276"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000257">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="9"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000276-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="314" mass="35405" checksum="BA56D87D091268FD" modified="2016-09-07" version="1">MAASEERTYPTTLEGFGYGFNQGGKLRQIDKETGKLTDRVFDYQVYTSLSENQAHYEALGDVITEYVYQRLEEKEGMKKLYVPDDVPPEEATFVFSTVEKLDRPKKLLVLIHGSGVVRAGQWARSLIINDCLDSGTQIPYIRRARELGYEVLLLNTNDNYRTVNGARKPIRGSRNPTEHAATVLEKYILASKPESVAIVAHSYGGVVTVELAQRYADFFRDKVFAVGFTDSVHAASLVPEALKKIGRNWVTAKDPLDTPLTITKHDIPRHSAGHIKHEMTSYSCMSALFEFLESRYAEFRSEEPQSKKSKGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P075</accession>
    <name>A0A182P075_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 20</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P075"/>
    <dbReference type="STRING" id="199890.A0A182P075"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000307-RA">
        <property type="protein sequence ID" value="AEPI000307-PA"/>
        <property type="gene ID" value="AEPI000307"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000307"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000307-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20529" checksum="6159C5B5BEDAB5D3" modified="2016-09-07" version="1">MASFVAKVVTRCEEALESKNLNLSECELIQVPDAVYHLMRHTELKTCDLSSNVITKISPKFAVKFSLITDLNLSHNQMARLPDELADLHSLEMLDISHNSFITLPAVVFKMPKLRELKANNNAIIDIDRDEIIASDSLELVDLRHNPLTPKCHDLLKHAVVSFRIELSERVKEEWEDLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0C4</accession>
    <name>A0A182P0C4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OSK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0C4"/>
    <dbReference type="STRING" id="199890.A0A182P0C4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000356-RA">
        <property type="protein sequence ID" value="AEPI000356-PA"/>
        <property type="gene ID" value="AEPI000356"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000356"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09972">
        <property type="entry name" value="LOTUS_TDRD_OSKAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033447">
        <property type="entry name" value="OSK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17182">
        <property type="entry name" value="OSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OSK" evidence="2">
        <location>
            <begin position="203"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000356-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="404" mass="45822" checksum="B1746C1E2361FE23" modified="2016-09-07" version="1">MVLLAQTTYYDNEEELKAQLRSVIITRSKAGATIDEIIEDYRELTGTHLLNMFFSRAELISYLCMMEGVWCSTDGAHGLMLWFCSTARTKHVVNMIQQQRSPRGTSSTYRRYMPRARANVPVHSNNVQQLGYATVATETTIPSHVAFGDVVATQPPETTSRPYQPYRVMRAPRAERKHPYARRAGGRPAGTGWRQSRSDELDFSMYGPSYHRHQLVGDDFFLAIAKWELGFPFDEGHAIDMSGLCISGLTLSEAAKRVELAPFIADHVLVNVGTVDLLHGRAMIDLIHDFDQLVARFRERNVEPIMTTLTPIANSGGRTTMTERLLKLNEYICRTCPRTIDLWKNFVNSDGSVRFECFQPGPRKVSGSIMPHVLWNKLGRQHMLGVLGNEIAAQLTTTEQWRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1D5</accession>
    <name>A0A182P1D5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1D5"/>
    <dbReference type="STRING" id="199890.A0A182P1D5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000717-RA">
        <property type="protein sequence ID" value="AEPI000717-PA"/>
        <property type="gene ID" value="AEPI000717"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000717"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000717-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="854" mass="95631" checksum="61B53039DDF1D441" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P273</accession>
    <name>A0A182P273_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NAB co-repressor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P273"/>
    <dbReference type="STRING" id="199890.A0A182P273"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001007-RA">
        <property type="protein sequence ID" value="AEPI001007-PA"/>
        <property type="gene ID" value="AEPI001007"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001007"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.2010:FF:000001">
        <property type="entry name" value="NGFI-A-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.2010">
        <property type="entry name" value="NAB conserved domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006989">
        <property type="entry name" value="NAB_co-repressor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039040">
        <property type="entry name" value="NAB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006988">
        <property type="entry name" value="Nab_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038398">
        <property type="entry name" value="NCD2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12623">
        <property type="entry name" value="NGFI-A BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12623:SF10">
        <property type="entry name" value="NGFI-A-BINDING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04905">
        <property type="entry name" value="NCD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04904">
        <property type="entry name" value="SAM_NCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nab N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="NAB co-repressor" evidence="9">
        <location>
            <begin position="226"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001007-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="48645" checksum="845AB6EDE5ECE603" modified="2016-09-07" version="1">VVTSTPSNEAELQLYRVLQRASLLNYYDTLLEMGGDDVQQLCDAGEEEFLEIMALVGMASKPLHVRRLQKALHEWMTNPSAFQSPLTNVDIPSRIPYSPEPGSIARSVTAASTGPYGGPSTVAGSFSNLTASASSSTNLPLTPPTPIPAAPATSSAAVAAAAAAAAASAASSTLGHLGTGVGTLGHHHLLHHHHHHHPLSSSNLSSTIRDQIGSTTGGSVQLTPALTEDQVAKIVQAAERLSRTLPRLEPRQQSIKKRSARDLEAVIAMSESDPRRMEEIRKYSAIYGRFDCKRRPEKPLTLHEVCVNEAAAQICKYIPALLTRRDELFPLARQVVRDCGFGHSASIRLTGLSQTQQNRGDELDTVQQLKRARLSSDTSSDMGKAGNGADRDLSDPDFGDLRTHTPRVLDPTGGSLGVQVISSSGGHIIAVANPALALSPALSEAISIKRETVSPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2D1</accession>
    <name>A0A182P2D1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2D1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001065-RA">
        <property type="protein sequence ID" value="AEPI001065-PA"/>
        <property type="gene ID" value="AEPI001065"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001065"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001065-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="523" mass="58494" checksum="AC4B9805765E631F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2J6</accession>
    <name>A0A182P2J6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="5 19">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 19">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17 19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Golgi apparatus membrane</location>
            <topology evidence="2 19">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="5 19"/>
    <dbReference type="AlphaFoldDB" id="A0A182P2J6"/>
    <dbReference type="STRING" id="199890.A0A182P2J6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001130-RA">
        <property type="protein sequence ID" value="AEPI001130-PA"/>
        <property type="gene ID" value="AEPI001130"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001130"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00218">
        <property type="entry name" value="GlcAT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000044">
        <property type="entry name" value="Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF50">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 17 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="115"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="16">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="18">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001130-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="432" mass="47652" checksum="1A2D60410DC32FE7" modified="2016-09-07" version="1">MQKPLHRSVTEKKPYIRRLTGSLPPAASMLRSYKLYLMLLVSSIFFIVCQNQGSITSLVSNVSAASSGPGNDLPLGGPEAVAAPLQALGNDGMELLYGDSEPALGAEKIRSRSLNFKDMPLKPNDRSSSTLSATSTSAATTSTTSSSTTTTARTTPTTTTTKVATTNGVASHSNVPYRFPVDTKQLPPLYIITPTYRRPEQIPELTRLGYTLKHVQNVLWIVVEDSENRTTSVARLLEEIGVPFVQLAAPMPAQYRKQKVKPRGVSNRNRALQWIRANATEGTLYFADDDNTYNLKLFEQLRHVRKVAMFPVGLISKYQVSSPVVKNGTITGFYDGWLGGRKYPLDMAGFAVSVKFLHSRPKAQMPFKPGYEEDGFLRSLEPLDLKEVELLASNCTEILTWHTQARKNPPAPALDRKKYGGTNLVQLTSWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3A4</accession>
    <name>A0A182P3A4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like</fullName>
            <ecNumber evidence="13">1.3.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">tRNA-dihydrouridine synthase 1-like</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U16 and U17 in cytoplasmic tRNAs. Affects the level of some mature tRNA and thereby the total cellular translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A182P3A4"/>
    <dbReference type="STRING" id="199890.A0A182P3A4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001388-RA">
        <property type="protein sequence ID" value="AEPI001388-PA"/>
        <property type="gene ID" value="AEPI001388"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001388"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000081">
        <property type="entry name" value="Dihydrouridine synthase 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05142">
        <property type="entry name" value="DUF702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="22">
        <location>
            <begin position="60"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="416"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="598"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00068883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00077078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001388-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="626" mass="70613" checksum="759A58B7C59BA9B1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3E8</accession>
    <name>A0A182P3E8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3E8"/>
    <dbReference type="STRING" id="199890.A0A182P3E8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001433-RA">
        <property type="protein sequence ID" value="AEPI001433-PA"/>
        <property type="gene ID" value="AEPI001433"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001433"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140616">
        <property type="term" value="F:iodotyrosine deiodinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032553">
        <property type="term" value="F:ribonucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02144">
        <property type="entry name" value="iodotyrosine_dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000004">
        <property type="entry name" value="Iodotyrosine deiodinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050627">
        <property type="entry name" value="Nitroreductase/BluB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026:SF90">
        <property type="entry name" value="IODOTYROSINE DEIODINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026">
        <property type="entry name" value="NADPH NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="117"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001433-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="312" mass="34983" checksum="CD1C92A1A18BF610" modified="2016-09-07" version="1">MASYLEDLVDRFISSSALVTYWNYIFPVLVGLYLAITLYDKHRYGHKKKLRITEPAATEKSGSKLDGIEYVGDLENADYDPLPALEDKPHVPYTGATVILAEDPLEAADRFYAIANNRRSVRKFSSRPVDVTVVERCIQVAGTAPSGAHTEPWTFCLVSDPSIKASIREIIEAEEFVNYTQRMAKQWVTDLRPIRTNHIKEYLTEAPHLVLVFKQTYGYKADSDGSSASKKQHYYNEISTSIATGMLLCAFQCAGLSSLVTTPLNCGPALRTLLERPPNEKLLVLLPVGYPAEDCTVPDLQRKPLEDIMVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3F6</accession>
    <name>A0A182P3F6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3F6"/>
    <dbReference type="STRING" id="199890.A0A182P3F6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001441-RA">
        <property type="protein sequence ID" value="AEPI001441-PA"/>
        <property type="gene ID" value="AEPI001441"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001441"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="96"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001441-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="185" mass="19982" checksum="99DADDE6858A48B3" modified="2016-09-07" version="1">MPDWRERDDSDRSYGGGGGGDSYSYDRERRDYRSDRGGYDRNGGGGGGGYRSGGYGGRRDDDGGYRGGGGGGGYRGNGGGGGGGGSRGPPRIDPATAKTEVFEVEADKVKFIIGRGGNKIREIQDRCRVSVQIDKARNENGANNVSVMGDQLNIDRARDMINTIINDDRRDREDDRRRDGVSMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3H6</accession>
    <name>A0A182P3H6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transmembrane protein 93</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3H6"/>
    <dbReference type="STRING" id="199890.A0A182P3H6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001461-RA">
        <property type="protein sequence ID" value="AEPI001461-PA"/>
        <property type="gene ID" value="AEPI001461"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001461"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001461-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="115" mass="12766" checksum="A3CE32B4FB7A9C9C" modified="2016-09-07" version="1">MSTTRVKTRETKTGEIIAYSDTAIRNNASAVEYCRTSMAALSGSTAGVLGLTGVLGFLFYVLAVLGLWQMLLLKSGSNWQKYFISRKSLLTHGFLSGLCTYVLFWTFLYGMVHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4B7</accession>
    <name>A0A182P4B7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4B7"/>
    <dbReference type="STRING" id="199890.A0A182P4B7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001753-RA">
        <property type="protein sequence ID" value="AEPI001753-PA"/>
        <property type="gene ID" value="AEPI001753"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001753"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019320">
        <property type="entry name" value="BORCS8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21146:SF0">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21146">
        <property type="entry name" value="MEF2B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10167">
        <property type="entry name" value="BORCS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001753-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="194" mass="21879" checksum="722554260AD0160F" modified="2016-09-07" version="1">MSQKVSTVNDPELQAKVKKTTEKISENMHIIANEPSLAFYRIQEHVRKVIPLIVDRRAEVVQLQQDLQGKCYDMEYAIGAVKDIEAADTSLKNVQELLKNAIFLKQQLKYVESRRPKKDTNSSVYKRLSAHITLDLPDLTDLSGVVRETTNRVEHMMSQARNSNNNINNNPPAGTTSSSTGGPTELQRSYTTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P524</accession>
    <name>A0A182P524_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P524"/>
    <dbReference type="STRING" id="199890.A0A182P524"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002011-RA">
        <property type="protein sequence ID" value="AEPI002011-PA"/>
        <property type="gene ID" value="AEPI002011"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002011"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF2">
        <property type="entry name" value="GH04238P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="50"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002011-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="412" mass="45763" checksum="2FE256BBE48C3ED2" modified="2016-09-07" version="1">MLQLRKSLNVDSVHITHLSVPRVYVLDNYHHQRQQHQYYARSELSARDDPDIPFDPASRELRAPDPAEHLVLDCEYVIEPHETGFVLKWLHNDVPIYQWIPPHRSPSSLNRMRDHVNRTFTVGNEAMHKHRALALMHPSQEFAGKYSCSVHTFQSFDIKSADLFIIVPESGFVLKYYRNLNDLVTVICSVYGIFPAPELSLWINDYRLENGTINEIPVADGLYDSSVSVQLVLYESLQPDDVIKCMVAVPGTEYRRTKETVFVDVNSRPFGESNSILDPFGTVSYGSSSSSSSSSTAKVPLTRAMSSSTAPSVTEPAPTPEASSVKVTTGQQQLPSSSAVAGTASTKETVPRPQIPSVIRLRPTASSTRVLTVQQSNPVDSDEIMNVLDFKELLNENLLYNSGATSIAAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P596</accession>
    <name>A0A182P596_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 223</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P596"/>
    <dbReference type="STRING" id="199890.A0A182P596"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002084-RA">
        <property type="protein sequence ID" value="AEPI002084-PA"/>
        <property type="gene ID" value="AEPI002084"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002084"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026100">
        <property type="entry name" value="Tmem223"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14549">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14549:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002084-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26869" checksum="C0E4242191ED8082" modified="2016-09-07" version="1">MILRLLSSLNGHLGKSSTILANLRNGYPSFGNVIRPTIYRGQSTQAPVNRVYDVNTKVPKDVMLFKYENPRFFKMLNIFALSQFLFWGYLCHFSYTTLKDAPVQDDGKEELPWYKRVNLGENKYRNGIAIMCFFIGYGVLFAAWMFTLRSVRFLVLRKGGQTVSVVTYAPFGTNRIMDVPLKYVSAQESRQAARVTVPVKIKNRALFYMLDMRGEFTNTKLYDYTVGLSRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6P1</accession>
    <name>A0A182P6P1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6P1"/>
    <dbReference type="STRING" id="199890.A0A182P6P1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002589-RA">
        <property type="protein sequence ID" value="AEPI002589-PA"/>
        <property type="gene ID" value="AEPI002589"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002589"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000030">
        <property type="entry name" value="Acetylcholine receptor subunit alpha-L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000012">
        <property type="entry name" value="Acetylcholine receptor subunit alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="17">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="58"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002589-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41177" checksum="201DF22E367E27E4" modified="2016-09-07" version="1">MVKIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMILVGLSVVITIIILNIHYRKPSTHKMAPWVRKFFILRLPKLLLMRVPNDLLKELAANKINYGIKISKSKFGAALAAHSQMQPNSGGSSPDSIRHMQGRPGGCNGLHTTTATNRFSGLVGALGGGLSGLGGYNGLPSVMSGLDESLSDVAPRKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVLDRLFLWLFTIASLFGTFAILCEAPSLYDDTKPIDIEYSIIAQKLFNLTVKDTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6Q3</accession>
    <name>A0A182P6Q3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 22</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6Q3"/>
    <dbReference type="SMR" id="A0A182P6Q3"/>
    <dbReference type="STRING" id="199890.A0A182P6Q3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002601-RA">
        <property type="protein sequence ID" value="AEPI002601-PA"/>
        <property type="gene ID" value="AEPI002601"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002601"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002601-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="138" mass="16162" checksum="0D346C444556422A" modified="2016-09-07" version="1">MQRNLTQSKEALLKSYNSRLKEDIRSMRENFEEIIRLAKGENDTQLSKITQCEQDTYETQVRAANIVRAGESLMKLVSDIKQYLILNDFHSVNEAICSNSTLYRTTQIDRDNKLMAVRDDMAADLYDLEEEYYTSIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6R8</accession>
    <name>A0A182P6R8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6R8"/>
    <dbReference type="STRING" id="199890.A0A182P6R8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002616-RA">
        <property type="protein sequence ID" value="AEPI002616-PA"/>
        <property type="gene ID" value="AEPI002616"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002616"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001826">
        <property type="entry name" value="Lethal (3) neo38, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000843">
        <property type="entry name" value="Potential zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001269">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002616-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="536" mass="56555" checksum="9AFD8171696B3007" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6V8</accession>
    <name>A0A182P6V8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA-binding domain-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6V8"/>
    <dbReference type="STRING" id="199890.A0A182P6V8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002658-RA">
        <property type="protein sequence ID" value="AEPI002658-PA"/>
        <property type="gene ID" value="AEPI002658"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002658"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119:SF0">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACB" evidence="6">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002658-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="258" mass="28205" checksum="7DCD5DFC06AC4A43" modified="2016-09-07" version="1">MADQTQEDDQLGLEGESPLEASFAQATKFLERNTAQFKQEQLLQFYGLYKQATVGPCNTPKPAIYSMAARAKWYAWDKVGKLETGAAMKEYVRLLDQLAPSWCERGSSSSPTDNATEPAWVSVSRPKRLSECSLPEGASKTLADRIKEEDLEGVQVMLGNGGEPATINRLDHEGLAAIHWAADRGNVDILATLLSVDGIDINLRDADGQTALHYASSCGNVECLQLLLRHGADRTIRDEEGETCLDVAYNQVIKACLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6Y0</accession>
    <name>A0A182P6Y0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6Y0"/>
    <dbReference type="STRING" id="199890.A0A182P6Y0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002680-RA">
        <property type="protein sequence ID" value="AEPI002680-PA"/>
        <property type="gene ID" value="AEPI002680"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002680"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000306">
        <property type="entry name" value="ADP-ribosylation factor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002680-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="180" mass="20155" checksum="EBDFF17721968B9E" modified="2016-09-07" version="1">MGGLFSYFRGLLGSREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVEQVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAIIYVVDSADKDRIGISKDELLYMLREDELAGAILVVLANKQDMEGCMSVAEVHQALGLEALKNRTFQIFKTSATKGEGLDQAMDWLSNALQARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P783</accession>
    <name>A0A182P783_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein 55 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P783"/>
    <dbReference type="STRING" id="199890.A0A182P783"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002785-RA">
        <property type="protein sequence ID" value="AEPI002785-PA"/>
        <property type="gene ID" value="AEPI002785"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002785"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF26">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002785-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="57247" checksum="ACEC4D18399D9F1C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7G5</accession>
    <name>A0A182P7G5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7G5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002867-RA">
        <property type="protein sequence ID" value="AEPI002867-PA"/>
        <property type="gene ID" value="AEPI002867"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002867"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20987">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20987:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130939" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002867-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11672" checksum="E3C95A7BA9E65C34" modified="2016-09-07" version="1">MKVLALMVLMLGVLVGATVASRCIRDNSNGEPGCKTKEEIDQGFWRHNYDPTRYWECTKLNERAILRSCQDQAFHPSQLECVDWDDWEWEPVCAPLTRPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7Y0</accession>
    <name>A0A182P7Y0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7Y0"/>
    <dbReference type="STRING" id="199890.A0A182P7Y0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003033-RA">
        <property type="protein sequence ID" value="AEPI003033-PA"/>
        <property type="gene ID" value="AEPI003033"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003033"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003033-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="454" mass="47308" checksum="E1C7F0956EEDCD81" modified="2016-09-07" version="1">EASEGLHGGGGVGGVGGGVGGGSSANSGILGLCTTTPHHGSGDGGALSGRRSTGSVSGAVGGGSGGSGGSGRDSSGMAATGGGVVSAAAGAAATSGSGRNSGGGSGGGGGSGGSDHPSHPHHHHHQHPHHQSGERGGSGGGSGAATAAAAVVAAVASLPVHTCMYCGVTFHNQNKLTRHILSHSLESLKFREATHLIHPHLALRHELTQVALAAQQAQSSSPSQLPSPHYGHHRGSGGPPTLEQMLDPTAEAMAELELAAVLASQPVGGLGLGPVCDDLHLLNFLLLYNLQQQQQQQQQQQQQQQQQLQLQQQQQQQQALFQRQQAQHQRNQQLSEHSTHCQQQHAAVASPTTTTTTTPHQAPHPHRHQQQQQLLMHPPHSSDPYPLLLQEMMHRHQRQQQHEQQQQQLLHQQQQQQHHHQLLPTATTTEDQQGQGRAKKKALPPGIGNLFGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P859</accession>
    <name>A0A182P859_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P859"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003112-RA">
        <property type="protein sequence ID" value="AEPI003112-PA"/>
        <property type="gene ID" value="AEPI003112"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003112"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130961" description="Secreted protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003112-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="18822" checksum="8F40011628BAE834" modified="2016-09-07" version="1">MWHGYRAVLYGVAMLIATVGSVAPDEDPLSQLALLLGDSSTGLGVIGGQEVSGPISIRDSIVGDIISISVRVNSTVRTNVSLELLQIVVCALNEYGHYGIEMADNEINQDYVNILALLLSSTGDVELFHQLSHAMGETAPSTVPPNTNENGAPAPPKDEISVEEALKKLFPKLAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA30</accession>
    <name>A0A182PA30_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vesicle transport protein GOT1B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PA30"/>
    <dbReference type="STRING" id="199890.A0A182PA30"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003784-RA">
        <property type="protein sequence ID" value="AEPI003784-PA"/>
        <property type="gene ID" value="AEPI003784"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003784"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003784-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15455" checksum="37AF31D919D9E3F7" modified="2016-09-07" version="1">MFEITDTQKIGVGLAGFGITFLFLGMLLLFDKGLLAIGNILFVCGLACVIGLERTFRFFFQKHKVKASISFFGGIAIVLFGYPLIGMLIEMYGFILLFSGFFPVAINFLRRVPVLGNILNMPGISRTVDWLAGESDRTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAA5</accession>
    <name>A0A182PAA5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A182PAA5"/>
    <dbReference type="STRING" id="199890.A0A182PAA5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003859-RA">
        <property type="protein sequence ID" value="AEPI003859-PA"/>
        <property type="gene ID" value="AEPI003859"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003859"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="8">
        <location>
            <begin position="67"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003859-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="397" mass="43293" checksum="3B89051E23DBD7AD" modified="2016-09-07" version="1">MIKTGMGSLVPRILRQQTAALPTTLVSVKNYATEATFETKPFKLHHLKEGPPTTGKVTKDEAVKYYRQMQTIRRLETSAGNLYKEKLVRGFCHLYSGQEACAVGMKGAMRPQDNIISAYRVHGWTYLMGVTPRGVLSELAGKQGGCARGKGGSMHMYAPNFYGGNGIVGAQVPLGAGVAMACKYKGNGGVCMALYGDGAANQGQIFEAYNMAYLWKLPCIFVCENNGYGMGTSAERGSCNVNYYQRGDVLPGIWVDGMDVVAVRLATEFAINHALTVGPLVMEVYTYRYSGHSMSDPGTSYRSREEVQEVRQTRDPISSFKDKILTAGLVTADELKAMDNEIKKEVDEATKQAKADGEIGLPELTTDVYSNNLDGDIRGVFPGSWLKHGTLKRAVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAI2</accession>
    <name>A0A182PAI2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ataxin-10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAI2"/>
    <dbReference type="STRING" id="199890.A0A182PAI2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003936-RA">
        <property type="protein sequence ID" value="AEPI003936-PA"/>
        <property type="gene ID" value="AEPI003936"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003936"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="6">
        <location>
            <begin position="350"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003936-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="451" mass="51399" checksum="80153128AD67E2BE" modified="2016-09-07" version="1">MIEIQQNITEKNYEKVLETLNTLDISQADSDSFRREVSILLESFYACHGSEEEPVNRIAIKCLNLLKRACALGETFQNAIVSRLEFLERVRDILVDEKVPENVRTNCLQLLANLCVQNRSNQERIITYMQTFLLTNVSSNGGYANASAMILYNGFIYKAVSLNLLDILNRLLGNVELNRTAQTEQPEFVCIFLEYLISESNEMVEALEKIDASKKLLLYRYLIEYIRQEDRRIHPIHPDVFKHLLAEFKKKSDMVLKTDNVQLDAQDTEEVFTLLVLIADSTCVEPYGSFLRHDGGLFLNLGCLLRQMQLLGKSETKNMFTPVQTIEEILRIKQGDTELDIESQISYSLRSAVVKALANLAYKSKKNQKLAREMDIIAAILECTNLDARNPLIKEWSILAIHNLCDDNLENQQFIAGLKKLGDAENSLITEYKSGTIRISDVNASSNSHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAK3</accession>
    <name>A0A182PAK3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAK3"/>
    <dbReference type="STRING" id="199890.A0A182PAK3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003958-RA">
        <property type="protein sequence ID" value="AEPI003958-PA"/>
        <property type="gene ID" value="AEPI003958"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003958"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
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            <end position="465"/>
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            <end position="214"/>
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            <end position="28"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003958-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="680" mass="76583" checksum="CEAA03968819FF64" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAN5</accession>
    <name>A0A182PAN5_9DIPT</name>
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        <recommendedName>
            <fullName evidence="6">Cytohesin Ubiquitin Protein Inducing domain-containing protein</fullName>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11819">
        <property type="entry name" value="CUPID"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
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            <end position="232"/>
        </location>
    </feature>
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        </location>
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            <end position="301"/>
        </location>
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            <end position="413"/>
        </location>
    </feature>
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            <end position="498"/>
        </location>
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    </feature>
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            <end position="1076"/>
        </location>
    </feature>
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        <location>
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            <end position="136"/>
        </location>
    </feature>
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            <end position="29"/>
        </location>
    </feature>
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            <end position="95"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="EnsemblMetazoa" id="AEPI003990-PA"/>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">Endoplasmic reticulum lectin 1</fullName>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
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        </subcellularLocation>
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        <property type="gene ID" value="AEPI004154"/>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0030970">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
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    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
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        <location>
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        <location>
            <begin position="19"/>
            <end position="480"/>
        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="11">
        <location>
            <begin position="329"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="313"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004154-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="480" mass="55326" checksum="5DABAA3FCC825998" modified="2016-09-07" version="1">MLFLHLFTLVAALRFTVSHDLKGFDDSVLFNLVWHTKDDIIDAPANSEEIFVTSANKERYRCLIPSITAKETTGEVEYSGPSPLELLEPLFTSTTCSYRIESYWSYEVCHGNYIKQYHEERHEKTSKLQEYFLGRWDKQKTEALKARYAQADSDKEQMKYKKIEGFNLPYLELEMDSGTICDLNGEPRVTKVLYVCYRFGKNEVYSLKETSTCNYEVIILTAALCTHPKYKPQDTEENKINCSPVGDAPRKPKALLQLEVEKLRQKYQQLSDGSIRGDPMRKDATFNFDWKPMDEEAGEGEGETPVSSMTRRPKKSKELTSLLEFLDGAYCLPGGSGWWKFELCFGKHVRQYHKDTSIYLGYFDVDKHREWLEKNPAARYKRKLENQISHFYTGGDVCDKTNQPRHVEVKLKCTESLGGSDVIALYLLEPRPCEYVLNVESSKICDIIPLATDDMLLPENLRQLEEETQLVLDSATNVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB52</accession>
    <name>A0A182PB52_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PB52"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004157-RA">
        <property type="protein sequence ID" value="AEPI004157-PA"/>
        <property type="gene ID" value="AEPI004157"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004157"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002027">
        <property type="entry name" value="Blast:Sal-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000570">
        <property type="entry name" value="Spalt like transcription factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000025">
        <property type="entry name" value="Spalt-like transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000215">
        <property type="entry name" value="Spalt-like transcription factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF87">
        <property type="entry name" value="HOMEOTIC PROTEIN SPALT-MAJOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="988"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1016"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1048"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="31"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="322"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="445"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="684"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="769"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1216"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1326"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="473"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
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            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
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            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="769"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="854"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1117"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
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            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1354"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1428"/>
            <end position="1445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004157-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1504" mass="159026" checksum="C7FEC5417107FEAB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBA2</accession>
    <name>A0A182PBA2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBA2"/>
    <dbReference type="STRING" id="199890.A0A182PBA2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004207-RA">
        <property type="protein sequence ID" value="AEPI004207-PA"/>
        <property type="gene ID" value="AEPI004207"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004207"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="bHLH-O_Cwo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CLUMA_CG001539, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
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        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="8">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
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        </location>
    </feature>
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        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
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        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004207-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="65729" checksum="50589CF7E2409966" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBE5</accession>
    <name>A0A182PBE5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBE5"/>
    <dbReference type="STRING" id="199890.A0A182PBE5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004250-RA">
        <property type="protein sequence ID" value="AEPI004250-PA"/>
        <property type="gene ID" value="AEPI004250"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004250"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904825">
        <property type="term" value="P:protein localization to microtubule plus-end"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF18">
        <property type="entry name" value="GAS2-LIKE PROTEIN PICKLED EGGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004250-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="95" mass="11034" checksum="E4986F7D9A59DD0E" modified="2016-09-07" version="1">MNTVLLESRPYRPFKSSEEYLYAMREDLAEWLNTMYPDLRINVENFMDRLDTGVALCKPEATVRQVVACCWASETKCDNARMPVACCLQNSGRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBF3</accession>
    <name>A0A182PBF3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBF3"/>
    <dbReference type="STRING" id="199890.A0A182PBF3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004258-RA">
        <property type="protein sequence ID" value="AEPI004258-PA"/>
        <property type="gene ID" value="AEPI004258"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004258"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="10">
        <location>
            <begin position="159"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="178"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004258-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="465" mass="53446" checksum="A15D7041B3326D0B" modified="2016-09-07" version="1">MATDLAKGCDDLQSELERARNNLKGLNDNIRRIFGRDPSNAEQYNNGREDAGGPNTPNGGHKKGGFGLKEGYDSRKRNSLGFDSPHGMGTRRDHTRQYFDGGPNSAKRRAIGETKSVFSRLSGPPNRDADYEKPRLFSRVIKEQPSKEDIVAAQGSDERSRARNRRIFGSLLGTLQKFSQEESKLKSKEEKKAMIEKKLEEQERLERENMQKEKQCLFIDRKRQQLEIRLLETKVAKMKALEMWEQSKRPLLNFIKTKTSPPIFYLPKRMNAAMEKKLTECQQEQQKMIDEKRQEVKESIAAVEERFQADMKSLEASNGKERMGYEHMKSSGSFDESFGAASKHDRFKLEDEEEYDDPHSAYHYEQDEQPELPEGPALPASMVPRFKITIHNTGRKADSSERRDVSTQESKAMRVSDSTMDVDTSLTEMDERRSKSPKRRKTTPIDRSAKNIQITFRTSSNSEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBK0</accession>
    <name>A0A182PBK0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBK0"/>
    <dbReference type="STRING" id="199890.A0A182PBK0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004305-RA">
        <property type="protein sequence ID" value="AEPI004305-PA"/>
        <property type="gene ID" value="AEPI004305"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004305"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000003">
        <property type="entry name" value="Class V chitinase CHIT5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF390">
        <property type="entry name" value="CHITINASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="168"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004305-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="583" mass="65682" checksum="599D08485C60C3C9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCG9</accession>
    <name>A0A182PCG9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCG9"/>
    <dbReference type="STRING" id="199890.A0A182PCG9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004624-RA">
        <property type="protein sequence ID" value="AEPI004624-PA"/>
        <property type="gene ID" value="AEPI004624"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004624"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000064">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF31">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="66"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="188"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004624-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="288" mass="31691" checksum="5C3CC382075400A7" modified="2016-09-07" version="1">MTLVEVIARALGDPAPYIGSSSSSSLFGVVGAATSNDVTAEPVRHQRSASDRAGPPTPPPYSFHFAHAVYNVSIPENSIIKTYAVQPPNEPRMGLHVTSDLEVRYKIVAGDKDRFFKAEERAVGDFVFLAIRLRTNNIVLNREKGDSYRLEVKATGTRREGKSRTTLEADTVIDVRVLDANDLSPLFYPTDYSVAITEDTPLHKSILHVVAEDADLGLNGEIYYSILDETEQFAVHPTTGVITLTRPLRFAERALHELTVVANDRGIGSTSRNQASKARVKIKVLQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCI2</accession>
    <name>A0A182PCI2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5-related protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in muscle cell metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCI2"/>
    <dbReference type="STRING" id="199890.A0A182PCI2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004637-RA">
        <property type="protein sequence ID" value="AEPI004637-PA"/>
        <property type="gene ID" value="AEPI004637"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004637"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000020">
        <property type="entry name" value="Cytochrome b5-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053100">
        <property type="entry name" value="Cytochrome_b5-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16740">
        <property type="entry name" value="CYTOCHROME B5-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16740:SF1">
        <property type="entry name" value="CYTOCHROME B5-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="51"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00055674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004637-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="463" mass="53816" checksum="D6D358C6891F4402" modified="2016-09-07" version="1">MTWSECTSFFFTSTRSCLQIQPSARLPWVMATNYITTISTKYPSFRDEPLKTVYRWLEGKRLDDGAEGLWRIHDTLYDFTDFIERHPGGPEWLRLTKGTDITEAFETHHITVRAEGLLAKYKVREATAPRAVRLTFRDDGFYRTLKRRVRDKLKDIDYGPAKRSKLIIDSMLAAAFGLAFLAIRLHSYALATASGLFVCWTMISAHNFFHQRDNWRMMAFNLAFSSYREWRVSHAISHHNFPNSILDLEISYFEPFLCWLPNPSIKSSVKRFASWLYGPLVYAFLFYGEFVKRLMETYETGKNTFFLDDLVTLILPTFMYVVGATSLWEVIKMWLFIVLVASFLFGLIGLNAAHHHPKAVHDGDQIPADIDFAVYQMAAVIDRSDTKGSQFMVLTSFGDHCLHHLFPTLDHGILPQLYPVFFETCREFETVYREMPWLQQIIGQHKQLARVDTMTYKPSEKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEM5</accession>
    <name>A0A182PEM5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEM5"/>
    <dbReference type="STRING" id="199890.A0A182PEM5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005380-RA">
        <property type="protein sequence ID" value="AEPI005380-PA"/>
        <property type="gene ID" value="AEPI005380"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005380"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02396">
        <property type="entry name" value="KH-I_PCBP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="58"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="267"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005380-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="504" mass="50949" checksum="B0B1F03EC91F9A76" modified="2016-09-07" version="1">MLGHSGAKINISDCSCPERIVTVSGSRSAIYKAFTLITKKFEEWCSQFQDNANTQGKPQIPIRLIVPASQCGSLIGKGGSKIKEIREITGCSIQVASEMLPNSTERAVTLSGSAEAITQCIYHICCVMLESPPKGATIPYRPKPQVNGPVIVANGQAYTIQGNYAVPAQETCTVYPLAITGGLHAGISGLADPLLKGTHLQGAIPPHHLQPIPDVSGIAKNPLAGLAALGLAGAIPSNTGGLNPTALAALAGSQLRTNNNRNVAPVQSQSHEMTVPNDLIGCIIGKGGTKIAEIRQISGAMIRISNCEERDSGNTDRTITITGNPDSVALAQYLINMSVELQKANLGDEAGAAAAAAAAAATAQVAGAQPATAGIVPPSAAATLTAAASAAAAAAANSGVTGAGATGANAAAAAAAVSNPLATAIPLAQLLAKPGTLNALNSLSALGSLTDLLGNLSSGAAAVAPIQTTGVNRPKTTRMRSPNTNNSMNGDSSKKSERNKFNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEX8</accession>
    <name>A0A182PEX8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEX8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005483-RA">
        <property type="protein sequence ID" value="AEPI005483-PA"/>
        <property type="gene ID" value="AEPI005483"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005483"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038875">
        <property type="entry name" value="PLA2_conodipine-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37687">
        <property type="entry name" value="AGAP006772-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37687:SF1">
        <property type="entry name" value="AGAP006772-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131215" evidence="3">
        <location>
            <begin position="18"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005483-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="728" mass="83205" checksum="162CB1477AA7B4EF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF30</accession>
    <name>A0A182PF30_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PF30"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005535-RA">
        <property type="protein sequence ID" value="AEPI005535-PA"/>
        <property type="gene ID" value="AEPI005535"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005535"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="8">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="9">
        <location>
            <begin position="394"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="11">
        <location>
            <begin position="704"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="10">
        <location>
            <begin position="915"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="12">
        <location>
            <begin position="1090"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1160"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
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            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005535-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1328" mass="149376" checksum="ECB20CCBF1A158A8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFQ7</accession>
    <name>A0A182PFQ7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription cofactor vestigial-like protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PFQ7"/>
    <dbReference type="STRING" id="199890.A0A182PFQ7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005764-RA">
        <property type="protein sequence ID" value="AEPI005764-PA"/>
        <property type="gene ID" value="AEPI005764"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005764"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011520">
        <property type="entry name" value="Vg_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950:SF15">
        <property type="entry name" value="PROTEIN VESTIGIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07545">
        <property type="entry name" value="Vg_Tdu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005764-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="23355" checksum="47502D09D82BDD52" modified="2016-09-07" version="1">MQASRSLCNIENPKKRPFNQDLYSSSGVPLAASSSTSAGSHSPCSPLLPPSLPSNMAAAAAAAQSSSALTSSATVTSVNQTAIPTIPLGALQRHITKEEDISTARSDTEGTISGAHNDSSCSSGPDSPHNLNQQQADASGLAAAAAAAAAAVAGGSGESSGGGGGGGGHMAGASGSGNSRAQYVSATCVVFTHYSGDAASVVDEHFSRALNFSDKNNKGKCGLFSSFLSCQTLCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFR3</accession>
    <name>A0A182PFR3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A182PFR3"/>
    <dbReference type="STRING" id="199890.A0A182PFR3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005770-RA">
        <property type="protein sequence ID" value="AEPI005770-PA"/>
        <property type="gene ID" value="AEPI005770"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005770"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.120:FF:000012">
        <property type="entry name" value="Prolyl oligopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="521"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005770-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="748" mass="85470" checksum="B338FED31563BB2C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFW7</accession>
    <name>A0A182PFW7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PFW7"/>
    <dbReference type="STRING" id="199890.A0A182PFW7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005826-RA">
        <property type="protein sequence ID" value="AEPI005826-PA"/>
        <property type="gene ID" value="AEPI005826"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="AEPI005828-RA">
        <property type="protein sequence ID" value="AEPI005828-PA"/>
        <property type="gene ID" value="AEPI005828"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005826"/>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005828"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF265">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005828-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="85" mass="10003" checksum="29D01CED0DD748D4" modified="2016-09-07" version="1">GVFIFNIVQWTPIKYLGYSYPFWAHAFGWFTALSSMLCIPGYMIWLWRNTPGDRANKIRLIVRIEDSVSQLRERMQADAEKGMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFX9</accession>
    <name>A0A182PFX9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="11">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182PFX9"/>
    <dbReference type="STRING" id="199890.A0A182PFX9"/>
    <dbReference type="ESTHER" id="anoga-ACHE2">
        <property type="family name" value="ACHE"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="AEPI005838-RA">
        <property type="protein sequence ID" value="AEPI005838-PA"/>
        <property type="gene ID" value="AEPI005838"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005838"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043083">
        <property type="term" value="C:synaptic cleft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001507">
        <property type="term" value="P:acetylcholine catabolic process in synaptic cleft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001445">
        <property type="entry name" value="Acylcholinesterase_insect"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF13">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00880">
        <property type="entry name" value="ACHEINSECT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007950992" description="Carboxylic ester hydrolase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="12">
        <location>
            <begin position="29"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="10">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005838-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="624" mass="69704" checksum="B5D8B69388EF52F2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFZ3</accession>
    <name>A0A182PFZ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CIDE-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PFZ3"/>
    <dbReference type="STRING" id="199890.A0A182PFZ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005852-RA">
        <property type="protein sequence ID" value="AEPI005852-PA"/>
        <property type="gene ID" value="AEPI005852"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005852"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01615">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003508">
        <property type="entry name" value="CIDE-N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12306">
        <property type="entry name" value="CELL DEATH ACTIVATOR CIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12306:SF22">
        <property type="entry name" value="DNAATION FACTOR-RELATED PROTEIN 2, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02017">
        <property type="entry name" value="CIDE-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00266">
        <property type="entry name" value="CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51135">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIDE-N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005852-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="441" mass="48384" checksum="75172D9BCB59AB93" modified="2016-09-07" version="1">MAREESRGKRPLKIWDSWRNVRKGLVVGSFEELIVRGKDKLGVPASEPVRLVLECDGTQVEDGEYFRTLANNTVLLLLRQGERWYPTGVDVIKAAISAIPKIVCETIHALELQDETPSWKIMDNKGRVTVVLHWDQRQGGGGGGQGGGGSSSSGGPGSSSIGLSNGPTSDKFSPSKKSLSTQNSIDKSSVSSQPRFPSPQITVINHDDPQSQMYHSARRLSKQGGSFDSAVGAVHVHTPECAHHAHMPTRAGSPGATECDFHCCALHEEGRKIAVHKNVATSPIQDGSASPQPPPSSMSDSRRTSTTKGHVRFLDIGPERDSSESETENTVMEDETVTSEKFLLLIDQLSVDQKRHLSIKDIGIILERLSSKILDVERLDRESESDDCYNWTIKATIRGDALRELGVIYNGNYYAISEHPGYKEENEENGEDAEEEDEDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PG02</accession>
    <name>A0A182PG02_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PG02"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005861-RA">
        <property type="protein sequence ID" value="AEPI005861-PA"/>
        <property type="gene ID" value="AEPI005861"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005861"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005677">
        <property type="term" value="C:chromatin silencing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053032">
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        </location>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005861-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1797" mass="198606" checksum="07CE122A111448A1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGU8</accession>
    <name>A0A182PGU8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Exonuclease 3'-5' domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
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        <cofactor evidence="2">
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
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        </cofactor>
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        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="gene ID" value="AEPI006157"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3'-5'_exonuclease_dom"/>
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        <property type="entry name" value="3-5_Exonuclease_domain"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="RNaseH_sf"/>
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    <dbReference type="PANTHER" id="PTHR13620">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
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    </dbReference>
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        <property type="entry name" value="DNA_pol_A_exo1"/>
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    </dbReference>
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        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="16">
        <location>
            <begin position="51"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="724"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="254"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061005"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069878"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006157-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="813" mass="91549" checksum="B9FA03576F8175C2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH68</accession>
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        <recommendedName>
            <fullName evidence="12">Guanylate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A182PH68"/>
    <dbReference type="STRING" id="199890.A0A182PH68"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006277-RA">
        <property type="protein sequence ID" value="AEPI006277-PA"/>
        <property type="gene ID" value="AEPI006277"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006277"/>
    <dbReference type="Proteomes" id="UP000075885">
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51022"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1072" mass="117737" checksum="51A3A436DB0FAD6B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI61</accession>
    <name>A0A182PI61_9DIPT</name>
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        <recommendedName>
            <fullName evidence="7">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
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    <dbReference type="PANTHER" id="PTHR11040:SF169">
        <property type="entry name" value="FI24038P1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
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        <location>
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    </feature>
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        <location>
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    </feature>
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    </feature>
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        <location>
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        <location>
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    </feature>
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    </feature>
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        <location>
            <begin position="475"/>
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    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006623-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="793" mass="85270" checksum="4F095269CB337DC4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIG1</accession>
    <name>A0A182PIG1_9DIPT</name>
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        <recommendedName>
            <fullName evidence="14">Munc13-4</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the unc-13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIG1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006723-RA">
        <property type="protein sequence ID" value="AEPI006723-PA"/>
        <property type="gene ID" value="AEPI006723"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006723"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04009">
        <property type="entry name" value="C2B_Munc13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF4">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="11"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="10">
        <location>
            <begin position="472"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="11">
        <location>
            <begin position="698"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="819"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006723-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="995" mass="113314" checksum="CDB2057A012587A2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ69</accession>
    <name>A0A182PJ69_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Cadherin-related tumor suppressor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PJ69"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006983-RA">
        <property type="protein sequence ID" value="AEPI006983-PA"/>
        <property type="gene ID" value="AEPI006983"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006983"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007424">
        <property type="term" value="P:open tracheal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000013">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000029">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000592">
        <property type="entry name" value="Cadherin-related tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000594">
        <property type="entry name" value="cadherin-related tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000768">
        <property type="entry name" value="Cadherin-related tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000207">
        <property type="entry name" value="Cadherin-related tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000263">
        <property type="entry name" value="Cadherin-related tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000286">
        <property type="entry name" value="Cadherin-related tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000329">
        <property type="entry name" value="Cadherin-related tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000037">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000080">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000101">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000106">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000131">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000005">
        <property type="entry name" value="Protocadherin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000035">
        <property type="entry name" value="Protocadherin Fat 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000709">
        <property type="entry name" value="Protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000118">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
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        </source>
    </evidence>
    <sequence length="3369" mass="364932" checksum="854820FA02C53C58" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJD0</accession>
    <name>A0A182PJD0_9DIPT</name>
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        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Arthropoda</taxon>
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            <taxon>Pterygota</taxon>
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            <taxon>Diptera</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Epiroticus2</strain>
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                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="3">Epiroticus2</strain>
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    <sequence length="222" mass="24968" checksum="A7191825597EB498" modified="2016-09-07" version="1">MAHTCRGTISLHGALIHTVDSCTFVISNGGTQTFHIKAANEVERQSWVTALELAKAKAIRAMESDEEEEDNTANTIPSEELNLVVRELTVRLENLKTCYDLITKHGAALQRALSELETGDDLANKTKIVSERATLFRISSNAMINACSDYLQTAQTQGHKWSKMLQHERDQKLHLEEMVEQLARQHSHLEQAATRHRPTVKVNISITVLLHCTQMTKDNMLN</sequence>
</entry>
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            <fullName evidence="3">Anaphase-promoting complex subunit 5</fullName>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
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            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJK5"/>
    <dbReference type="STRING" id="199890.A0A182PJK5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007119-RA">
        <property type="protein sequence ID" value="AEPI007119-PA"/>
        <property type="gene ID" value="AEPI007119"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007119"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042476">
        <property type="entry name" value="APPBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46575">
        <property type="entry name" value="AMYLOID PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46575:SF1">
        <property type="entry name" value="AMYLOID PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007119-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44641" checksum="3E9950F6EEC47252" modified="2016-09-07" version="1">MCDYPSLVNIQLQILSNPLLISDFIRNFSNNLTPLVLCLQWLESVKQSLPIQLFRQYKKLIDEKIRTGGLFDFDYRCGLRIGTFLTETGWLVEAIGILQLTQQHAQFGTAEELTVLRHLMRAQTLAGKLIDASKTYDRMKRMLSNVIRQTMAIRHLPGKESEVQRLQDLQAAVCHSFSLYNFEDLNYVSSYDYGIQSLNMINYRSPCRLVIDVLRQVARVFLIHKKYEKAIEMMKLAIGLVAQEYGRVSALYAATLEDSAILLLACNQVSESVDVYGDAQQLYAELYGARNLLLSLAQGDLAYGLCLQAYVTGHRDRALCHVARAAGNYQRILPPDHRMLAQVRRLHATINLLTFDRETNGAIHELSVDCFNHKEIEPLSVRDIYPSIHALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK31</accession>
    <name>A0A182PK31_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PK31"/>
    <dbReference type="STRING" id="199890.A0A182PK31"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007297-RA">
        <property type="protein sequence ID" value="AEPI007297-PA"/>
        <property type="gene ID" value="AEPI007297"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007297"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007297-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32057" checksum="DCFB8851A4BA4EEB" modified="2016-09-07" version="1">MELLATMEVPTAGPETYCRLCLGKDSLLRVFAAERSEQSDSGTSTSPSCTNELVEKIYECTNIKLSSTVDAGCAICYRCLQAVQDFYHFRVRSNKVNDLIQVTTVVANGDGGSGDYGEGNNNGDNDEASKRGPGVTPTSPSKQATSVTAKPSRKLLLPSCPVVAAASRGERKYRCRYCPKSFHTETALTEHGKRTHVAGRQHHCPNCLAQFHHAPSLARHMRSRSCFAFSKYRCRVCSESFPERDQWANHIRIHAKDFPHQCPDCWSQFKHKATLRRHANTVHLLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKJ0</accession>
    <name>A0A182PKJ0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKJ0"/>
    <dbReference type="STRING" id="199890.A0A182PKJ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007457-RA">
        <property type="protein sequence ID" value="AEPI007457-PA"/>
        <property type="gene ID" value="AEPI007457"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007457"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016922">
        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21983">
        <property type="entry name" value="HMG-box_SMARCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46232">
        <property type="entry name" value="SMARCE1 REGULATOR OF CHROMATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46232:SF1">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="70"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="70"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
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        <location>
            <begin position="361"/>
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    </feature>
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            <begin position="380"/>
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        </location>
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        <location>
            <begin position="400"/>
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        </location>
    </feature>
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        <location>
            <begin position="448"/>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="487"/>
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        </location>
    </feature>
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        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
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        <location>
            <begin position="612"/>
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        </location>
    </feature>
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        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
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        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007457-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="750" mass="80363" checksum="5C232EF99912E52B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL51</accession>
    <name>A0A182PL51_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PL51"/>
    <dbReference type="STRING" id="199890.A0A182PL51"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007668-RA">
        <property type="protein sequence ID" value="AEPI007668-PA"/>
        <property type="gene ID" value="AEPI007668"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007668"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000437">
        <property type="entry name" value="Beat-IIIc, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF5">
        <property type="entry name" value="BEATEN PATH VA, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007668-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="169" mass="18900" checksum="EF137400DE88531C" modified="2016-09-07" version="1">MHNALTIARCLQLTEISVPDVVDVRETVTLSCSYDMGTHKLNSVKWYKDEREFFRYSPMMPKSIMTFDVEGVTVLQNSTEQICNQFRCSIQLHQLNIRSSGSYRCEISGDAPEFKLAHGVGNMTVAGKCFSCVDPGAAPKARCTQVTNLLPFARNHPSETTSKTMKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL93</accession>
    <name>A0A182PL93_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Negative elongation factor E</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex, causes transcriptional pausing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the NELF complex, which is at least composed of TH1/NELF-D and NELF-E.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM NELF-E family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PL93"/>
    <dbReference type="STRING" id="199890.A0A182PL93"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007710-RA">
        <property type="protein sequence ID" value="AEPI007710-PA"/>
        <property type="gene ID" value="AEPI007710"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007710"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000448">
        <property type="entry name" value="Negative elongation factor E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033102">
        <property type="entry name" value="NELFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17250">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17250:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="187"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="32"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007710-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="301" mass="33329" checksum="875C454248B076B5" modified="2016-09-07" version="1">MVYIHFPSNLTEEELMLQAKYAKLRKKKKALQALKAPKQEPEKNLLPKRPADARDAREVARKLLKSGAIQAIQKPQPKQEGSFKRPKGQERKRTQPELSPAGQYQSFGASAEFESSSSATPTIGSAVANASTTPTESPNSPAEKETSRVQNLYQQFANEREKEDQSDKSKPVVGSGDASKDKPRSGNTVYVSGNKVTENFLKKHFSEFGEILNISMEIEKGRGFITFSKTESADKAISDLHSKTVGGIQLQVQLARRQPQINPINDAGSSAVWSALATNRSQKGKHKDNRELVCYDHDDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLA5</accession>
    <name>A0A182PLA5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PLA5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007722-RA">
        <property type="protein sequence ID" value="AEPI007722-PA"/>
        <property type="gene ID" value="AEPI007722"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007722"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.160.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.180.11">
        <property type="entry name" value="Methuselah ectodomain, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044860">
        <property type="entry name" value="Methusela_ecto_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023311">
        <property type="entry name" value="Methusela_ecto_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010596">
        <property type="entry name" value="Methuselah_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036272">
        <property type="entry name" value="Methuselah_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051384">
        <property type="entry name" value="Mth_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06652">
        <property type="entry name" value="Methuselah_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63877">
        <property type="entry name" value="Methuselah ectodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131613" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="13">
        <location>
            <begin position="34"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="752"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="795"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="846"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="927"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1052"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1085"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1122"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1156"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1207"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1261"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1287"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="208"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="688"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="1049"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1341"/>
            <end position="1360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007722-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1360" mass="156159" checksum="B98A6A85A9D85112" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLL8</accession>
    <name>A0A182PLL8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182PLL8"/>
    <dbReference type="STRING" id="199890.A0A182PLL8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007838-RA">
        <property type="protein sequence ID" value="AEPI007838-PA"/>
        <property type="gene ID" value="AEPI007838"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007838"/>
    <dbReference type="UniPathway" id="UPA00753">
        <property type="reaction ID" value="UER00739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000016">
        <property type="entry name" value="Putative choline-phosphate cytidylyltransferase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="55"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    <sequence length="397" mass="44995" checksum="9D7ABD9F81FC4C0A" modified="2016-09-07" version="1">MNHSIFCRSLQTICKQAPYSTELDAIRERERCDYTQKITYQMARSGTAPRMIRVYADGIYDLFHQGHARQLMQAKNVFPNVYLIVGVCNDKLTHSRKGRTVMNDEERYEAIVRDAPWELDDEFIEKHKIDFVAHDEIPYSTDDSDDVYAKIKAKGMFVATERTEGVSTSDIVARIVKDYDIYVRRNLARGYTAKELNVSFLSEKKFRFQNKMVELKDKVRKGKDDFITKWEERSTDLIKTFLLMFGKERISMFLSDSKQRIRSALSPPGSPGSGSNHSLNDCEDDLESPDSVLDSPPSKRSNMLLRNSTDVLRSRQHLLSEEDDEEQGLVGSRSPPPVLEDDDDDDDDEAYLDTRSRPSSNYNISLMAGGDGSSSGGGAALNSSSSSGSRSYGNRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLZ2</accession>
    <name>A0A182PLZ2_9DIPT</name>
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        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">Epiroticus2</strain>
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    </reference>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="7">Epiroticus2</strain>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PM16"/>
    <dbReference type="STRING" id="199890.A0A182PM16"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007988-RA">
        <property type="protein sequence ID" value="AEPI007988-PA"/>
        <property type="gene ID" value="AEPI007988"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007988"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0727">SH2 domain</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="202"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007988-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="690" mass="76405" checksum="F12F38DD9DE04D0D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM51</accession>
    <name>A0A182PM51_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Scavenger receptor class B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an olfactory role that is not restricted to pheromone sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PM51"/>
    <dbReference type="STRING" id="199890.A0A182PM51"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008024-RA">
        <property type="protein sequence ID" value="AEPI008024-PA"/>
        <property type="gene ID" value="AEPI008024"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008024"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF114">
        <property type="entry name" value="FI02050P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008024-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57638" checksum="24C2C71D0F040C04" modified="2016-09-07" version="1">MRCCRWYLGVGLGLGTAATGFIFLFAWRDIFDILVSEEKSLLPGTALYKEWRRPPMRPTWQMYVYNWSNAQAFLEHAPEVNAPNFEEFGPYEYDEITEVVDVKFHQANDTLSYRKRTFFRRSALQTARNSESKPEEITTVNFVALLASHLGRRMDYSVQRELSFMMHNFHQNLTVTRPVGQLLLAGYREPMMDPMRKLVCTNKSHSTACQDERLAYFRTFNVSRRASELYSLNVGSKDPAKYGTVRSWSRTAARSGPEESHSCDGLDDLTGEFFPSRIERGAAIRLVLPELCRRLTLEFDREQSVEGIVGYRYQVRPVRPFSAELADPGMERCPHASIRLGRYGILNSNECHGLPLYESDLANASASDQHSTATLSGGGLYYVLEPVTGSVLESNLALAYHTFLRPNEHIALLQSVPLVRVPLFRFTRFHRLSDAKAAKLRQLLHLLDVGHQLALAGCVVGAAIVILSALYACWEARKPRKAHNDEYRIIGTQLSNEAREDHLLKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM60</accession>
    <name>A0A182PM60_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PM60"/>
    <dbReference type="STRING" id="199890.A0A182PM60"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008033-RA">
        <property type="protein sequence ID" value="AEPI008033-PA"/>
        <property type="gene ID" value="AEPI008033"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008033"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008033-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14112" checksum="DBC7801E85D8AE49" modified="2016-09-07" version="1">MSSLIRALSWPLISQSQGGGGGGAGGPGGPGSPIDGLDGLGNGAGHCKKNGGIPPSPTFQQLMAARRLLCRRYYPEGGWGWVVIVVGVLVHTMTHGMQLSYGPLMGSVMRYFGKPFTDTVPPAIPGWKKLPRVNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMA8</accession>
    <name>A0A182PMA8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGAP2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMA8"/>
    <dbReference type="STRING" id="199890.A0A182PMA8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008081-RA">
        <property type="protein sequence ID" value="AEPI008081-PA"/>
        <property type="gene ID" value="AEPI008081"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008081"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF11">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="9">
        <location>
            <begin position="42"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008081-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="279" mass="32295" checksum="0092A06407A60B2E" modified="2016-09-07" version="1">MLPQYERLVNVDGDDTGRGGVGGYASSSGSGSLRRSTFRVRFGRLAVATVMLPVMGFLFCVIWSLLYNFEQANATHCLVYNFLPSLSAAIGNYQPQRFVWQFSVLFHAPFRYSIAFLYKNHHLALLSRKHRKEWAYLACILNIVELSSLVGLSLWTSSNNYEIHKFCFSAFVICSIIYMYLVVLINRLTRTEELLTLAERKSLRFKRRLLVINVASILFAIYFFVRHNNHCEPGIYSLFALSEYVFVYSNIGFHMTAYWDFINANVYFHWRTGIHFSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMB3</accession>
    <name>A0A182PMB3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMB3"/>
    <dbReference type="STRING" id="199890.A0A182PMB3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008086-RA">
        <property type="protein sequence ID" value="AEPI008086-PA"/>
        <property type="gene ID" value="AEPI008086"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008086"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="322"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008086-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="526" mass="59911" checksum="AE4939F0B0CDE9CD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMJ9</accession>
    <name>A0A182PMJ9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sensory neuron membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an olfactory role that is not restricted to pheromone sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMJ9"/>
    <dbReference type="STRING" id="199890.A0A182PMJ9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008173-RA">
        <property type="protein sequence ID" value="AEPI008173-PA"/>
        <property type="gene ID" value="AEPI008173"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008173"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF109">
        <property type="entry name" value="SENSORY NEURON MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008173-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="167" mass="18332" checksum="BDE901560403248F" modified="2016-09-07" version="1">MKHAPVVLTLPHMLGVAEEYTALIDGMDPDPERHQIFVDVEPYTGTPLNGGKRVQFNMFLRRIDAIKLTDRLQPTLFPVIWIDEGIALNEDMVKLIDDSLMKVLSLLDVVQWALIGVGLLLAVLMPTVYFVKRCRGDSSRSVSPAVTATTSAASLSTVAGVTGERNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMQ4</accession>
    <name>A0A182PMQ4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMQ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008228-RA">
        <property type="protein sequence ID" value="AEPI008228-PA"/>
        <property type="gene ID" value="AEPI008228"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008228"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008228-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="146" mass="16092" checksum="94338B590DAA418E" modified="2016-09-07" version="1">MVTIFTIPSLATALRCYTCNSNDNSECFAPPTNFTEELVRDNRTIPGRLLLECPKDPQGRKPLCRTIRLLVLGGSLPDHERIVRECGYERSRRPCYKVDNGGHEEHVCHCSTDGCNGGSQIAGCGVVLLALASTGLLLRSMQRDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMV8</accession>
    <name>A0A182PMV8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMV8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008282-RA">
        <property type="protein sequence ID" value="AEPI008282-PA"/>
        <property type="gene ID" value="AEPI008282"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008282"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31109">
        <property type="entry name" value="PROTEIN FAM207A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31109:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN SLX9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008282-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="241" mass="27887" checksum="E2758B4F8BEFEABB" modified="2016-09-07" version="1">MGKINKKLPKPKLIPKPFEDTSKVKGPFPIYRSTPVQLNGPEPPSFKILDEKQAKKKGSNVSKRIPPADETDTKSSSAQAEEPLDEEVKTKKLRKLAISRLSKKEKKQFRKEEMLKKVELTKQAFKQDRERKKREQTAITGDLKPLLDALPSLESLFDVKSAGKVFKTGVPKYDKKAEPKTKKERRAQRLKQHKKEFLKRCSTIKRVLKDKTFQKDPKKMIADHIRNTRREQLERLMQSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN26</accession>
    <name>A0A182PN26_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PN26"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008350-RA">
        <property type="protein sequence ID" value="AEPI008350-PA"/>
        <property type="gene ID" value="AEPI008350"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008350"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008350-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="102" mass="11123" checksum="40813DDDFEB4CB23" modified="2016-09-07" version="1">MGIESESYGSNITRHWKPVDKCRNIHTNLVTDAGPNMIDMPAMDDHESTNIIDIDLKAKMSRSGQQTPPTTNHRQVGRSSGTALLESFLALTVAAVLGFALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN27</accession>
    <name>A0A182PN27_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper type II ascorbate-dependent monooxygenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN27"/>
    <dbReference type="STRING" id="199890.A0A182PN27"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008351-RA">
        <property type="protein sequence ID" value="AEPI008351-PA"/>
        <property type="gene ID" value="AEPI008351"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008351"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.230:FF:000001">
        <property type="entry name" value="Monooxygenase, DBH-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF40">
        <property type="entry name" value="MOXD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="6">
        <location>
            <begin position="167"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008351-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37709" checksum="DA7DA9B4D6299B3D" modified="2016-09-07" version="1">YEPVFDSSTSVLYLNHLILYECQGLSPDLEQLSRQRGQPCFRLQPMHCNTVVANWARGSDGFTFPPEAGYPLESHQATYYMLETHYNYPDYTYDFSPFYRKNLSKQQRNMNIKSREETAETPAEDSEPRATDEDLADDSDDSIAMEQQMVDNSGLKLYYTHRLRQHDAGVLSVGLDPNWRHIIPPRQEKVVSQGHCIGACTQHAFPRDGINIFAVMSRTHLIGRQVQLRQIRGNTELQPIMRDTNIDPSYQDYRRLAVPTRVLPGDSLVAECIYDSSSRKSITLGGMTTREEICLILTLYYPRQRELTSCHSLPSLPTVLHSLGIEELAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN30</accession>
    <name>A0A182PN30_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PN30"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008354-RA">
        <property type="protein sequence ID" value="AEPI008354-PA"/>
        <property type="gene ID" value="AEPI008354"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008354"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
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            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
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    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
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            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
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            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="491"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="550"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="608"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="669"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
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            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="789"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="848"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
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            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
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            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
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            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
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            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="1144"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
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            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
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        <location>
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        <location>
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            <end position="2102"/>
        </location>
    </feature>
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        <source>
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        </source>
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        </source>
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        </source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008354-PA"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2103" mass="225413" checksum="1FD8A4693015985E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPK1</accession>
    <name>A0A182PPK1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPK1"/>
    <dbReference type="STRING" id="199890.A0A182PPK1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008880-RA">
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        <property type="gene ID" value="AEPI008880"/>
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    <dbReference type="Proteomes" id="UP000075885">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="6"/>
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        <property type="entry name" value="Zinc_finger"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF57">
        <property type="entry name" value="ZINC FINGER PROTEIN 154-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
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    </feature>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008880-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="555" mass="62251" checksum="9BCFBFEC101169B7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPW4</accession>
    <name>A0A182PPW4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Origin recognition complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPW4"/>
    <dbReference type="STRING" id="199890.A0A182PPW4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008994-RA">
        <property type="protein sequence ID" value="AEPI008994-PA"/>
        <property type="gene ID" value="AEPI008994"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008994"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000673">
        <property type="entry name" value="Origin recognition complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="10">
        <location>
            <begin position="228"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="9">
        <location>
            <begin position="324"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008994-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="469" mass="52953" checksum="E26E1001CA8C9E1B" modified="2016-09-07" version="1">MDAFVKQIARTLPCRDSYVRQLYRYFRTGDPFPPALYIYGQSSTGKCSILREVLRRWGPEGDGTIMYAQLNAISCYTNKILFETIARQLEGVALSSSNNYSTSQKLEHAKDFLAELRAQLDPAASYVIVLRNAERLRDMAHNLLPLFLQLPEATGLNISVVLVSSLPFEKFYTKTGLPPVVKLFVPEYTRVEMQRILMHDYAQHVAELAGCSGKHQQWLADVTEEFHRNYVNLFLGTFWKVCRDVKELRLVAAECFPPYCEPIRDGTIPVHDSMKLWRNVTKTLRTALSTMYMRLGTNHRTASSSTGNGVAPDGTGWLAQHLELPYYAKYLLIAAYLASNNAAKEDRRLFMKNHGKQRKRLQAVNARAKVVEKMTTKLGPKAFNLDRLLAIFYAILDEKVGLTCNLLAQISTLVHLKLLTYASSAEGGAGVSMLDGSATRLQCTVGLDFIMQIGRMVGFNVRQYLTDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ44</accession>
    <name>A0A182PQ44_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQ44"/>
    <dbReference type="STRING" id="199890.A0A182PQ44"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009074-RA">
        <property type="protein sequence ID" value="AEPI009074-PA"/>
        <property type="gene ID" value="AEPI009074"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009074"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF134">
        <property type="entry name" value="ECHINOID, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="41"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009074-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="136" mass="15120" checksum="4FB0B7D1FA933179" modified="2016-09-07" version="1">MNTSYSRDNGRFECRVKASGTGADVHQEYYNLTVLTPPQPPFVEPVELRATEDEKFDLTCSSIGGSPDPTITWYRVGSEKPLKSTVSKGGSKDLRTSSILSIVPRREDDGAKFRCVVWNRAMSEKDKLETTVTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ72</accession>
    <name>A0A182PQ72_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PQ72"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009102-RA">
        <property type="protein sequence ID" value="AEPI009102-PA"/>
        <property type="gene ID" value="AEPI009102"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009102"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057971">
        <property type="entry name" value="PKHA4-7_TBCA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752:SF9">
        <property type="entry name" value="KRAMER, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752">
        <property type="entry name" value="PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25541">
        <property type="entry name" value="TBCA_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="3">
        <location>
            <begin position="1906"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="912"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1228"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1362"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2412"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="2596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2642"/>
            <end position="2692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1820"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1925"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1994"/>
            <end position="2021"/>
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            <begin position="49"/>
            <end position="73"/>
        </location>
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        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="223"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="291"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="321"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="822"/>
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        </location>
    </feature>
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        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1119"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1260"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1370"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1426"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2092"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2132"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2440"/>
            <end position="2455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2456"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2642"/>
            <end position="2652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2658"/>
            <end position="2667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009102-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2692" mass="292146" checksum="D117733E16CC8D4C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQY8</accession>
    <name>A0A182PQY8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the HMX homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQY8"/>
    <dbReference type="STRING" id="199890.A0A182PQY8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009369-RA">
        <property type="protein sequence ID" value="AEPI009369-PA"/>
        <property type="gene ID" value="AEPI009369"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009369"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000053">
        <property type="entry name" value="H6 family homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051300">
        <property type="entry name" value="HMX_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="200"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="202"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009369-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="328" mass="34857" checksum="D028BCBC48F2213B" modified="2016-09-07" version="1">MCRASQAGRSHLIVRSVTSASGPICPSSIFHSSSKIPSSFHSMRVLFSSSPNSRCRLGFMSQWSAIANRYAALCPPGWPWPPTSHRMPFHSPNNDNSTSAIENQSPSLTPPPSQQSKSPSPHPAFLGGHRAAGCGAGGGMVGMGGGGGGPGGPGGPGGVSNGDDCESDDDGQEIIEEDDESDRPSDSASPNSNGSAMQAKRKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLRLTETQVKIWFQNRRNKWKRQLAAELEAANMANMAHAAQRLVRVPVLYHEGATGGFVPPPPHPHSQQLYYTTSAGRAGSPPRPPLSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRL4</accession>
    <name>A0A182PRL4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRL4"/>
    <dbReference type="STRING" id="199890.A0A182PRL4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009598-RA">
        <property type="protein sequence ID" value="AEPI009598-PA"/>
        <property type="gene ID" value="AEPI009598"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009598"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07567">
        <property type="entry name" value="biotinidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012101">
        <property type="entry name" value="Biotinidase-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040154">
        <property type="entry name" value="Biotinidase/VNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043957">
        <property type="entry name" value="Vanin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609:SF14">
        <property type="entry name" value="BIOTINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609">
        <property type="entry name" value="BIOTINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19018">
        <property type="entry name" value="Vanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131712" description="CN hydrolase domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009598-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="530" mass="59022" checksum="AD0F44F46C1A378B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRM9</accession>
    <name>A0A182PRM9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">TATA sequence-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">TATA-binding factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TATA-box factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Transcription initiation factor TFIID TBP subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (Tafs). Binds DNA as monomer. Interacts with TFIIA-L heterotrimer. Interacts with Taf1, Taf2, Taf5 and Taf12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRM9"/>
    <dbReference type="STRING" id="199890.A0A182PRM9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009613-RA">
        <property type="protein sequence ID" value="AEPI009613-PA"/>
        <property type="gene ID" value="AEPI009613"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009613"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000992">
        <property type="term" value="F:RNA polymerase III cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001092">
        <property type="term" value="F:TFIIA-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009613-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="321" mass="35400" checksum="945A516D0DE1E7B0" modified="2016-09-07" version="1">MDQMLPSPGFSIPSIGTPLHQPEEDQQILPHAYQQQQSMPHMTPMGGLSSSNYTMPAIGSSTGKSMHTYAPSFSTPQNMIQPQTPQSLMSPMVPMTESKASATPSQAQGAGSVRDPENIGSVNIHQTMGPATPMTPMTPSEPAILPQLQNIVSTVNLSCKLDLKKIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEDDSRLAARKYARIIQKLGFTAKFLDFKVQNMVGSCDVRFPIRLEGLVLTHGRFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVRQEIYDAFENIYPILKSFKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS52</accession>
    <name>A0A182PS52_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PS52"/>
    <dbReference type="STRING" id="199890.A0A182PS52"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009787-RA">
        <property type="protein sequence ID" value="AEPI009787-PA"/>
        <property type="gene ID" value="AEPI009787"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009787"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="135"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009787-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="220" mass="24210" checksum="60B6FAA09A2641FB" modified="2016-09-07" version="1">MSITKVTSEDQYKQLIGATKVSVVLFSAEWAEQCKQISDVMTELAKQAEFKSLQFLDVPAEDLSELSMRHQIDSVPTVLFLRAGTAVDRIDGVDVGLLTQKAKKYAGMPTTPSAGGDGTGNLEERLKGLINRSKVMIFMKGDRNTPRCGFSKQLIAIVNDTGVEYDTFDILTDEAVRQGLKTFSNWPTYPQVYVNGELIGGLDIIKELLEGGELKETLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSP5</accession>
    <name>A0A182PSP5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein pet117 log mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSP5"/>
    <dbReference type="STRING" id="199890.A0A182PSP5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009981-RA">
        <property type="protein sequence ID" value="AEPI009981-PA"/>
        <property type="gene ID" value="AEPI009981"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009981"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131831" description="Protein pet117 log mitochondrial" evidence="6">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009981-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="7960" checksum="1110C41B06DC3F01" modified="2016-09-07" version="1">MSTAAKLTFISACIASGSLIAYVHYSQAADRERLHEGVRRDVERQRLKQAASAGTEIIPDEGSGSRPQGSQLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PT42</accession>
    <name>A0A182PT42_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1</fullName>
            <ecNumber evidence="11">3.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:75163"/>
            <dbReference type="ChEBI" id="CHEBI:78907"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42305"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42584"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82605"/>
            <dbReference type="ChEBI" id="CHEBI:82606"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65221"/>
            <dbReference type="ChEBI" id="CHEBI:78911"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:42309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:33751"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="3.1.3.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78930"/>
            <dbReference type="ChEBI" id="CHEBI:78931"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42321"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.27" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182PT42"/>
    <dbReference type="STRING" id="199890.A0A182PT42"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010128-RA">
        <property type="protein sequence ID" value="AEPI010128-PA"/>
        <property type="gene ID" value="AEPI010128"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010128"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14524">
        <property type="entry name" value="PTPMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000060">
        <property type="entry name" value="Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042165">
        <property type="entry name" value="PTPMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044596">
        <property type="entry name" value="PTPMT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712:SF1">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="25"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="107"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010128-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="198" mass="23049" checksum="FF53115A2334D31F" modified="2016-09-07" version="1">MFARITFYPSLFYNVMMEKITSRNWYDRIDENVILGALPFRSMAQELVRKENIKAVVSMNEDYELWAFSNNRARWAKHGVEFLQLETTDIFESPCQEKLWKGVNFMNRFLPPGERMALLPPADGPPAEPGTIYVHCKAGRTRSATLVGCYLIMKNGWSPEKAVEHMRECRPHILLRSKQWEALRLFHQTKCPPPNTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTH9</accession>
    <name>A0A182PTH9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTH9"/>
    <dbReference type="STRING" id="199890.A0A182PTH9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010265-RA">
        <property type="protein sequence ID" value="AEPI010265-PA"/>
        <property type="gene ID" value="AEPI010265"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010265"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000145">
        <property type="entry name" value="Dual specificity protein kinase CLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="735"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1060"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1082"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="764"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010265-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1092" mass="121423" checksum="CADB03FE6265FDBF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTX0</accession>
    <name>A0A182PTX0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AEPI010406"/>
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    <dbReference type="Proteomes" id="UP000075885">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RRM3_Bruno_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000016">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Euk_RNA-bind_prot"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="207"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010406-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="292" mass="30384" checksum="F0E869F1EF8BECB9" modified="2016-09-07" version="1">MEGCSAPLVVKFADTQKEKDAKRMQQMQTNLWGMTGINQPITQSVTPLTASAHPNPPQQQTPFLAADAISPPLSLLQQLQAVAQQQHLLQGLSAQTDTTSAAAASLLAAPISLQNLVTLAGITQPSLQTAAAAAAQTPATAISNAATSLWATGADTATSLTSYAALPQFGAAAATAAAFTPTPLTTPTLAQAVAAAAGKQIEGPEGCNLFIYHLPQEFTDTDLASTFLPFGNVVSAKVFIDKQTNLSKCFGFVSFDNVSSAQAAIQAMHGFQIGTKRLKVQLKRSKDASKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU92</accession>
    <name>A0A182PU92_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methanethiol oxidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Diptera</taxon>
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            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenium-binding protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU92"/>
    <dbReference type="STRING" id="199890.A0A182PU92"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010528-RA">
        <property type="protein sequence ID" value="AEPI010528-PA"/>
        <property type="gene ID" value="AEPI010528"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010528"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008826">
        <property type="entry name" value="Se-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300:SF0">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05694">
        <property type="entry name" value="SBP56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010528-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54609" checksum="E721673ED351BEC8" modified="2016-09-07" version="1">MGETKCKCGPGYATPLDAVRNGPAEKLLYVVCVQPNLEEEHGDYLATVDVDPTSPTYCQIIHRTYTNSKRNELHHSGWNTCSSCHFVPGDKEIPTRDRLVLPCLNSDRIFIVDTGTDPRAPRLAKVIEPDVLKSANCTAPHTTHCLPNGNIMISVMGDAEGNARGDFVEFDKNFELVGTWARGDRQALCGYDYWYQPHFNVMVASEWGAPKLFRRGFRPTDCDDRTQYGCRLNFYRWQERELFQTIDLGDDGITPLEIRFLHNPTENQGYVGCAFYANVYRFYQKPGSDEYTAEKVIDVPVKKVQGDNGEIEQMGGMMTDILISLDDRFLYFSNWRHGDVRQYDITDRAHPRLTGQVFLGGAIQSDAPRRVLDDPELKEPPAPVHVKNRRLLGGPQMLQLSLDGRRLYVSSSLFSPWDKQFYPEMVAAGGTIVQLDIDVENGGMKLNENFLVDFGNEPYGPGLPHEMRYPGGDCTSDIWLVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU96</accession>
    <name>A0A182PU96_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PU96"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010532-RA">
        <property type="protein sequence ID" value="AEPI010532-PA"/>
        <property type="gene ID" value="AEPI010532"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010532"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010532-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="161" mass="16430" checksum="A893260B284E26DC" modified="2016-09-07" version="1">MTVGSVKHPNVLPQPAAASSARAYNGTGSSGGVGGGIGRSDGSRTHGSVGSGAHRSSGLGGGRTSPQALSNMSSAYGRIRPATKRCLFDRPDPIVTKRMCDDNDRAERQRTINRYGFDPHTGHGLISASSLSSASSTGPSSSSSSGSSVSAGMLHHNRCHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVG8</accession>
    <name>A0A182PVG8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apolipoprotein D</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVG8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010955-RA">
        <property type="protein sequence ID" value="AEPI010955-PA"/>
        <property type="gene ID" value="AEPI010955"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010955"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000003">
        <property type="entry name" value="Apolipoprotein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF62">
        <property type="entry name" value="LIPOCALIN_CYTOSOLIC FATTY-ACID BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013437069" description="Apolipoprotein D" evidence="10">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="11">
        <location>
            <begin position="43"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010955-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="205" mass="23385" checksum="151A69431AFE34E1" modified="2016-09-07" version="1">MQFAVDVRALVVVLVALGSIALGQRIVSQPCPDPASRPIVQYFDLQRYVDGRWYKISRYDQHFEKDCDCGYATYTPQTDGSVKVQNCCERLPNTTVKCSIGKAVVSFPDEFPLEGRFNVTFGGPPKNSNYWILDTDYDNYALIYYCKNLSESKSAEAAWVLSKQRTIHPSVQETVDKLVDKYFVRQDMRVTEQSQAKCKYDSNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVL8</accession>
    <name>A0A182PVL8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVL8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011005-RA">
        <property type="protein sequence ID" value="AEPI011005-PA"/>
        <property type="gene ID" value="AEPI011005"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011005"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131974" evidence="2">
        <location>
            <begin position="28"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011005-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="179" mass="20376" checksum="3AB7882A09B81514" modified="2016-09-07" version="1">MLPMTTHPGKIVLVVLLLAASALSVDATDSAHKPHSRQPRGLGFFHKITHLGSLLYQQYNDTTYTLKNVYDLLSNEFTDTFTTTTPDPRTTPTTPDPSTSTTPKYRISRAELGRILNRNYRGLQKLFRLEWNDAWNQTKYNIDEYKRELKNSAFPPRNRTAGPINVDLSVEVKAELKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVR5</accession>
    <name>A0A182PVR5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TORC_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVR5"/>
    <dbReference type="STRING" id="199890.A0A182PVR5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011052-RA">
        <property type="protein sequence ID" value="AEPI011052-PA"/>
        <property type="gene ID" value="AEPI011052"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011052"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011052-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="133" mass="14893" checksum="1DB7390E82C477E5" modified="2016-09-07" version="1">MVFSGLDETYLTMNNGLGIRTHTGHGNGHTQVHQNSTQQANQLNSLNCQNMQNMQNINMSNMFNGTSEPLLSLPNTQSLIEPQTPTIPEIVFTDDFEADLGLGHMDFQSIQMLSDTSTMIDPMDEDSFRRDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVZ5</accession>
    <name>A0A182PVZ5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVZ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011132-RA">
        <property type="protein sequence ID" value="AEPI011132-PA"/>
        <property type="gene ID" value="AEPI011132"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011132"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011132-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="478" mass="53347" checksum="636533175D32DC2B" modified="2016-09-07" version="1">PYHNFFCVNCIPKPTATQGGNTRSLFQEGCLFDNEEFLSTFRGYECYNPHYELYSKTNRVIITESCYILPNYKRIARKPMPAIVKMRKLIEIFPAVHQMPFKKYDSMQAMYSDVRKKYREIRNYYSTNNTGSFMDFIDLMVERTPLVRPSASDRTRRLREIDTSSSFPSETLQIRENSEESTEIPSSVSDASTLHISSQSVGEEPRVAELPLPDSQQSAAATVLSTLDVQQSSSVSDASTLHISSQSVGEEPRGEEVPLPESQQSTASTVINTLDVQQSNQFNISSQDANIESVLALPLSESVESLATNIELDSLSPVLPTRVTMHRIHDSQEAGPSGLQQQQPRTQETPSSTTIEPSTADGPQPKRRRLAIPVNMTPEQAQRTKQVKRWDIEVMGEEVCNKAGADVGVPNFDRFKTEKPTTGKEGHLETGSSTSMSCVWLARNVVCLTDVLDLNYVLDSNHVLDSNVLDSNSFQLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW93</accession>
    <name>A0A182PW93_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PW93"/>
    <dbReference type="STRING" id="199890.A0A182PW93"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011230-RA">
        <property type="protein sequence ID" value="AEPI011230-PA"/>
        <property type="gene ID" value="AEPI011230"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011230"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031874">
        <property type="entry name" value="Cuticle_Acp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12336">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12336:SF0">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15955">
        <property type="entry name" value="Cuticle_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131864" description="Cuticle protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011230-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="13279" checksum="B99726BDD2E4B985" modified="2016-09-07" version="1">MKCIAAALAVIALAVAAEAGYAAYPYAGYPYAGYGATVVQANAPAWPYAGYPYAHAGFPYAHAAAYPAAVAAYAAPHAALLAAPHAPLASVAHHAGVVPGATSVTATRGAVHVAPLPGHAVSQKQLNLAPAPGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWI0</accession>
    <name>A0A182PWI0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWI0"/>
    <dbReference type="STRING" id="199890.A0A182PWI0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011317-RA">
        <property type="protein sequence ID" value="AEPI011317-PA"/>
        <property type="gene ID" value="AEPI011317"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011317"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008048">
        <property type="term" value="F:calcium sensitive guanylate cyclase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF198">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011317-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="111" mass="12855" checksum="7FADFCAACD081980" modified="2016-09-07" version="1">DGSIEFEEFIRALSVTSRGNLDEKLHWAFRLYDVDNDGFITRDEMYNIVDAIYQMVGQQPQAEDDNTPQKRVDKIFDQMDKNHDDRLTLEEFREGSKADPRIVQALSLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWN9</accession>
    <name>A0A182PWN9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWN9"/>
    <dbReference type="STRING" id="199890.A0A182PWN9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011376-RA">
        <property type="protein sequence ID" value="AEPI011376-PA"/>
        <property type="gene ID" value="AEPI011376"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011376"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP9-like helix-turn-helix" evidence="1">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="2">
        <location>
            <begin position="73"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011376-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="28385" checksum="5CB834DC94FD5267" modified="2016-09-07" version="1">MKNMLKNTLSSNQIDLIMKEKKRVRWTKDEVSSAMTLRYFGKRAYDYMLKDLNYPLPSISTLQKYARHINLREGILEDVLVFMGNFVTSLKRKDAKCILSFDEMKIQYTIEYDSSVDEVIGPHNYIQVVMARGVFKNWKQPIYIGFDKKMTREILVDIIKKLHNKAINVVGVVSDNCSSNISCWKELGVLDFRAPYFEHPAIWIYLAKSVKMYDVQQSFYLVLHLLHYDVTCQMKKIWQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWP6</accession>
    <name>A0A182PWP6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWP6"/>
    <dbReference type="STRING" id="199890.A0A182PWP6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011383-RA">
        <property type="protein sequence ID" value="AEPI011383-PA"/>
        <property type="gene ID" value="AEPI011383"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011383"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011383-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="242" mass="27502" checksum="B71C371A7F855F0E" modified="2016-09-07" version="1">MLLALLRRKLKLNLPADGRTLLKTPTKVGFEIQSALGGQYWYRGIENALQTYFQDVVPQVNTFSMQVFLDGLPLFKSSARQLWPILIKVEELPEAAMMLVGLFCGHSKPDNVEGYLRPLVLEINDLQRRGLQFGDKTVQLKLRMIVADSPARCFAKVVDAELRTDAEFRSRADKEHHKSWRSLLEELEGFDMVVANIGDGDGGNGSSSNRDLRKEHHGWLGCDSSHFNQYSSETRTQQEHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYV8</accession>
    <name>A0A182PYV8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYV8"/>
    <dbReference type="STRING" id="199890.A0A182PYV8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015026-RA">
        <property type="protein sequence ID" value="AEPI015026-PA"/>
        <property type="gene ID" value="AEPI015026"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015026"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF103">
        <property type="entry name" value="CYTOCHROME P450 6BS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131918" evidence="16">
        <location>
            <begin position="18"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015026-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="496" mass="56447" checksum="E5D331010AABEC9F" modified="2016-09-07" version="1">MSHFLWFLSAALSLCLALCFLHFRKKYSFWRELGIPFVPAGFPLGNIQHTSHQMLDLYKELKGKHPIGGVFQFTEPVAMITDPEMIKNVLVRDFRHFYDRGGYADGTHDPLSGHMLNSESDRWRVLRHGSSPIFSTGRLRAFFPEMLRMMDEFRAFLDAKLASEGETVELKGMLGQLTTDISVRFLLGGEGNNLNAPERDLYQAITNGAFILPSLWKQFLMTCYRSVAKKLRLRVYTRELTEAMKHLVAKTIDDRAEGSANACRRINLIDQLLKLPGFEGKGSLTLEEIAGQVFLFVGAYETNSLTTFYCLHELAQRLDLQQRARACVLEALDKHGGITYEAIADMPYLDQCINETLRKNPPSINLIRVTTEDYPVPDSTGVVLPKGLNVVIPVYAIHYDAEYYPDPERFDPDRFAPEASSNRTPYTFLPFGGGPKNCIGYRQGKMHLRTMLAMLLCSYEFSECPKIIQGTRSEKHSVLKLKGNLWLRVRKLHRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PL07</accession>
    <name>A0A240PL07_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A240PL07"/>
    <dbReference type="STRING" id="199890.A0A240PL07"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015321-RA">
        <property type="protein sequence ID" value="AEPI015321-PA"/>
        <property type="gene ID" value="AEPI015321"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015321"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11328">
        <property type="entry name" value="AmyAc_maltase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167704" description="alpha-glucosidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="44"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015321-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="602" mass="68695" checksum="AA9FB6ADEDA82A18" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PM17</accession>
    <name>A0A240PM17_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit 6B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PM17"/>
    <dbReference type="STRING" id="199890.A0A240PM17"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015295-RA">
        <property type="protein sequence ID" value="AEPI015295-PA"/>
        <property type="gene ID" value="AEPI015295"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015295"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000004">
        <property type="entry name" value="Trafficking protein particle complex subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015295-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="154" mass="17849" checksum="905A3FB6F792A717" modified="2017-10-25" version="1">MAEEAIFEFLHSEIVNYTLSKENSKENDLSTLEYIGFTTGYRIIERLTREWPRFKDELDTMKFICTDFWSSIYRKQIDNLRTNHQGVYVLQDNAFRFLTRLSSGSQYLEHAPKFVAFTCGLVRGGLANLGITSTVTAEVQTMPSCKFHIQVNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PPX9</accession>
    <name>A0A240PPX9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">trypsin</fullName>
            <ecNumber evidence="12">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A240PPX9"/>
    <dbReference type="STRING" id="199890.A0A240PPX9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015414-RA">
        <property type="protein sequence ID" value="AEPI015414-PA"/>
        <property type="gene ID" value="AEPI015414"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015414"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF97">
        <property type="entry name" value="GH13245P2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0222">Digestion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012964116" description="trypsin" evidence="13">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="46"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015414-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="272" mass="28921" checksum="DB0AFEDC758E2A2F" modified="2017-10-25" version="1">MWNKFTILLSVSIALAACTGTRAALNYRVSSRLSPIIAPYLAGKRIVGGFVIDISDVPYQVSLQYNHQHHCGGSILNRRWILTAAHCIDPHTALKPTVRIGSSEHASGGAVMNIARIVPHPGHSANTNNYDIALLELESALTFSDKVQPVALPEQDEPIEEGTMGIVSGWGLTLSESDSNAVLRATNVPIVDQQECNKAYHSYGGVTGQMFCAGFKQGGTGTCSNDSGGPFVAEGKLIGVVSWSHKCALAGYPGVYARVASAREWIRASSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FGK1</accession>
    <name>A0A9I3FGK1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A9I3FGK1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015509-RA">
        <property type="protein sequence ID" value="AEPI015509-PA"/>
        <property type="gene ID" value="AEPI015509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015509-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="261" mass="28053" checksum="399F2F281E0C188D" modified="2023-06-28" version="1">TFDDERYYQSITPTPALPVPATIQAVAPATAVTTVITSDNSFQSEYIPVPRGDERYEFAASMMPRDTRMYEPTGLVSASGPIGDATTGAGGGGGSLSNAGPAPPPVVPLSYRGDERHYYPVVSTITSSYLLDNRQYEQSLNSPSMMHERLYQPTTHTITSGMLYNERSHYESASIAAVGGAGPPPPPHLSSMANNSDCHAVDIMMRSDASVAAAAAAAAAAGIEHAEASWRAEMMERQDEIDRQYLVLLPREDKIEPQDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FGL8</accession>
    <name>A0A9I3FGL8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A9I3FGL8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015534-RA">
        <property type="protein sequence ID" value="AEPI015534-PA"/>
        <property type="gene ID" value="AEPI015534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF54">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="2">
        <location>
            <begin position="138"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015534-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="420" mass="47654" checksum="DEAAAE5D5E386149" modified="2023-06-28" version="1">MKSSLNIPEYVRDALAGVAQRLGFTLNQHSVDYDFRAFENNRSVVSVLYRVTFREEPREVTVLCKVPPLEADDTLLALFEREVFVYGKLLPALEQFQRTRQAAETANTSSTSEEDLSLPFAPSCYHAHCDAKKGEGIIVLEDVQRRGFSNRHKFEPMDYDHARLAMVQLGRFHATTLALKKHQPELFEQYRYMGNVTGERVLAMEGFEQAMEQAFEAASATLNQADVGRREKLARLRGCFAEELQNISDTELSEPFCVVCHGDYAGDNMMFSYNGGFPNRMVMLDWQLAKYGSPALDFVHAVFLSTDEAFRRNHYDNMLQTYHNALLNHLERLGDDSATEWFPLTVLMRLIKLQARQALVLGLLHIPLTVASEEAALAAEDETDEGREDSSSVRISDTSDAKYQSRMAGLLKDVFRFGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZG3</accession>
    <name>A0A182NZG3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZG3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000043-RA">
        <property type="protein sequence ID" value="AEPI000043-PA"/>
        <property type="gene ID" value="AEPI000043"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000043"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000043-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="109" mass="12091" checksum="70985E116D5970AA" modified="2016-09-07" version="1">MPVSTAGFVRAKAKVFSASERGFQQLEAQLSPYIDPTGELRVGRRLRNADLPEEGRHPAILSAKHPLSVLLAEACHLQLLHAGPQLWYPDYIQQLQARAKHSNQSASDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZH0</accession>
    <name>A0A182NZH0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZH0"/>
    <dbReference type="STRING" id="199890.A0A182NZH0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000050-RA">
        <property type="protein sequence ID" value="AEPI000050-PA"/>
        <property type="gene ID" value="AEPI000050"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000050"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF46">
        <property type="entry name" value="SERINE PROTEASE P83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="67"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000050-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="245" mass="26389" checksum="D0E44C63FC1945A7" modified="2016-09-07" version="1">MSGGLLQGTCGGMLKGCCHRTAKSANIGIDASTAVDLTNVPALEYGPVQNDPSCGISLAKQTAQRRIVGGDDAGFGSFPWQAYIRIGSSRCGGSLISRRHVVTAGHCVARATPRQVHVTLGDYVINSAVEPLPAYTFGVRTINVHPYFKFTPQADRFDVAVLTLERTVHFMPHIAPICLPEKNEDFLGKFGWAAGWGALNPGSRLRPKTLQAVDVPVLDNRGQPGIYHRVANTVDWISHITQIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZP7</accession>
    <name>A0A182NZP7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.</text>
    </comment>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZP7"/>
    <dbReference type="STRING" id="199890.A0A182NZP7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000128-RA">
        <property type="protein sequence ID" value="AEPI000128-PA"/>
        <property type="gene ID" value="AEPI000128"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000128"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="77"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000128-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="203" mass="23612" checksum="B7D77EC2ADB45CD3" modified="2016-09-07" version="1">MNIPSYRPNYYNLDDIAVTQERIPCRTTQDLHMMGFLDASEKSPNLSNNHTLELPLWVMLQQDERNPHFEAQIPDIFSAAYKEIYQADANFVELGALCKFYYELGIYLTRYDVTNGVAEMLHSTAQERLRGLKDLCQNVGNDSLNVASKFDFNERLLFNEGTKTNKLLDDWLQERQVHIKSTEIAVNIRKRKRSLDGETQEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZU2</accession>
    <name>A0A182NZU2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZU2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000173-RA">
        <property type="protein sequence ID" value="AEPI000173-PA"/>
        <property type="gene ID" value="AEPI000173"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000173"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000173-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="196" mass="21935" checksum="FEDED0C113188BB5" modified="2016-09-07" version="1">MVGVWSSGRAGCGGRVYSGLRSRRHGLVGSEPPGVRVMQKVKTVCPGHGVIRVKMKAKATVRIVLFLVLLELLAMVDQGHPLPVGRSEQQRGVSSIGFPSLFHDIKHQFGSIGHDLRKLITSLMGATQVVYWKPPFKREPVRRADYTHRLQTVNRAPRLTTTTSKPKTRQSRRKKAYTGDDDIFDDFFSLDSLGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0N7</accession>
    <name>A0A182P0N7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0N7"/>
    <dbReference type="STRING" id="199890.A0A182P0N7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000469-RA">
        <property type="protein sequence ID" value="AEPI000469-PA"/>
        <property type="gene ID" value="AEPI000469"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000469"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000070">
        <property type="entry name" value="mismatch repair endonuclease PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.20:FF:000019">
        <property type="entry name" value="PMS1 homolog 2, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="238"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="735"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="483"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000469-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="937" mass="104558" checksum="7EA24D22D54BB152" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0V6</accession>
    <name>A0A182P0V6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0V6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000538-RA">
        <property type="protein sequence ID" value="AEPI000538-PA"/>
        <property type="gene ID" value="AEPI000538"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000538"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000538-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="102" mass="10878" checksum="5CAD6EC21C877675" modified="2016-09-07" version="1">MVSMDGEAHPNMTLAAVGLGALVALIILLTLIAFITRRERSSQSKELAQQSTTLPATVPGRRKGTIELQPPAQKTPPGGSVPPRCVTFTNDLELVDVVVTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P145</accession>
    <name>A0A182P145_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P145"/>
    <dbReference type="STRING" id="199890.A0A182P145"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000627-RA">
        <property type="protein sequence ID" value="AEPI000627-PA"/>
        <property type="gene ID" value="AEPI000627"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000627"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000627-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="229" mass="25149" checksum="5CDB1EACFE0C78FA" modified="2016-09-07" version="1">MWDVLKEYPAARVRLEAIAVKRLEKYKKAPLEKVAMGRCQSTPGLVETKGRTTIEDMWISPTTAITSAGSMMAPSYPPPAGSRITSPRSHRGDVCGSRQPQSPGSISPSVHSSEERPRSRTASHLARPQSQPCRTGPPCGSLTHIESSGATPLLGSHEALEGEIKRLRERLHTVESENFTLNAKLAQQQWEVEHRLAEIEMQICGASSASSVSQENETEDLERNRESII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P160</accession>
    <name>A0A182P160_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P160"/>
    <dbReference type="STRING" id="199890.A0A182P160"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000642-RA">
        <property type="protein sequence ID" value="AEPI000642-PA"/>
        <property type="gene ID" value="AEPI000642"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000642"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF46">
        <property type="entry name" value="CUTICULAR PROTEIN 30B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130666" evidence="3">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000642-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="97" mass="10905" checksum="F17A5E704861A5A8" modified="2016-09-07" version="1">MAFKYYILFALVAAASAAVLPVAVKHIEYQDAPAEYQFQYSVHDDHTGDIKSQQEERHGDNVVGQYTLIDADGYRRVVDYTADEHNGFNAVVRPGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1K2</accession>
    <name>A0A182P1K2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine synthase</fullName>
            <ecNumber evidence="12">2.7.8.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Serine-exchange enzyme</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:27606"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Phospholipid metabolism; phosphatidylserine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the phosphatidyl serine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.29" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A182P1K2"/>
    <dbReference type="STRING" id="199890.A0A182P1K2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000784-RA">
        <property type="protein sequence ID" value="AEPI000784-PA"/>
        <property type="gene ID" value="AEPI000784"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000784"/>
    <dbReference type="UniPathway" id="UPA00948"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF15">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="119"/>
            <end position="139"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="464"/>
            <end position="487"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000784-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="503" mass="57651" checksum="1B4CE953F18B0384" modified="2016-09-07" version="1">MKKRSGSPPPGPVSSADGGIGSEPLLHGSQHQHTMAVNEFKFINERPVDDISLNFFYKPHTITLLAVSIFGVMYFAFVRDQSDIQENIWAGMVCVIFFFLIISVLAFPNGPFTRPHPVVWRMLFGLSVLYLMLLQFLMFQDYKSIMGIFYWFDPKLRDFHIDMEKQYAANCSDMSFERIWSHVDVFAWGHFLGWAFKAVLIRHMGILWAISVMWEITEITFAHLLPNFAECWWDALILDVLVCNGFGIWCGLKICKLLEMREYKWASIRDISSTTGKLKRAVLQFTPESWAPVRWLDPKITYMRFVSVCQLVLLWQLTELNTFFLKHIFEMPPSHPVVIGRLVFVGLFTAPSVRQYYIYVTDTRCKRLGTQCWVYIAILVSEAILCIKNGKELFERTQVKNIVVWLMIQAVLSVLFVYGCMLWHRYVEEDDSRDGSPVKQTNRTFKDSAIVSGDSKGNKGGSSTPVKRSPQSTPTKKVRSQQQQANSVPAGGSAGKSAREHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1Y2</accession>
    <name>A0A182P1Y2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1Y2"/>
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        <property type="gene ID" value="AEPI000916"/>
    </dbReference>
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            <end position="256"/>
        </location>
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        <location>
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            <end position="64"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000916-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="256" mass="28120" checksum="282E92D6AFC33ABA" modified="2016-09-07" version="1">MPFIDDELLWSPDNDGRMVDLQACLQTESNQATASQTAELASELNTLEEQLDNDSDELLRQLTENTFELEQFFQDFPATEIKVEENNNDLQLDEETNGQIFLQNCSQFLTSAAAAAQLSALSVTEPNDLDGGLQRLCSGGNDQLVGSGGLTTQQLQEQLLLAQAQGLLQQNRFNNSLLAEKLLQNHHQQQQQQHHQQQHLHHAHASQNGVTNLDALSAVPSSSSSNNHHNSSNSSSSNGGRGNKPPDIVIKGKRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2K5</accession>
    <name>A0A182P2K5_9DIPT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Metazoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2K5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001139-RA">
        <property type="protein sequence ID" value="AEPI001139-PA"/>
        <property type="gene ID" value="AEPI001139"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001139"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130714" evidence="1">
        <location>
            <begin position="39"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001139-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="93" mass="10502" checksum="11B10840E9102D01" modified="2016-09-07" version="1">MAPGRESALCIISSSSRSSLISYCCWALLLMCLTIAVAAPVSAENHCSEHRYEHSLNTHHLQFTKEIPDREYGVLKQFKSLHCCGKGYRSIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2S0</accession>
    <name>A0A182P2S0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NR LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2S0"/>
    <dbReference type="STRING" id="199890.A0A182P2S0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001205-RA">
        <property type="protein sequence ID" value="AEPI001205-PA"/>
        <property type="gene ID" value="AEPI001205"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001205"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06930">
        <property type="entry name" value="NR_LBD_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000036">
        <property type="entry name" value="Nuclear hormone receptor FTZ-F1 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000037">
        <property type="entry name" value="Nuclear hormone receptor FTZ-F1 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="244"/>
            <end position="262"/>
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            <begin position="408"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51030"/>
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        <source>
            <dbReference type="PROSITE" id="PS51843"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001205-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="964" mass="100717" checksum="4539E067DE15DD08" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3C7</accession>
    <name>A0A182P3C7_9DIPT</name>
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        <submittedName>
            <fullName evidence="4">LAM_G_DOMAIN domain-containing protein</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AEPI001412"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001412-PA"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="747" mass="79519" checksum="0BF0443B0BD382A6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3P3</accession>
    <name>A0A182P3P3_9DIPT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3P3"/>
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        <property type="protein sequence ID" value="AEPI001528-PA"/>
        <property type="gene ID" value="AEPI001528"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001528"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001528-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="86" mass="9969" checksum="EA87D23A2B54B37A" modified="2016-09-07" version="1">MSLFFFRLHNLQREEANKKRKKQQQQQQQQQQRQRQRRGAKVFRGVSCNSGISHLTLGPSRLFEKTPMSPSDSLDEIALQIPSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3R7</accession>
    <name>A0A182P3R7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3R7"/>
    <dbReference type="STRING" id="199890.A0A182P3R7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001552-RA">
        <property type="protein sequence ID" value="AEPI001552-PA"/>
        <property type="gene ID" value="AEPI001552"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001552"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001552-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="61" mass="6657" checksum="C4EB7453F1E5B133" modified="2016-09-07" version="1">MLLTYNCRLDCATREEHCDDIQERPHVTTLISSLANYSNTIAPAPTDPDAKPAPAAARMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3S6</accession>
    <name>A0A182P3S6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182P3S6"/>
    <dbReference type="STRING" id="199890.A0A182P3S6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001561-RA">
        <property type="protein sequence ID" value="AEPI001561-PA"/>
        <property type="gene ID" value="AEPI001561"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001561"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000030">
        <property type="entry name" value="Dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF46">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007950970" description="Dipeptidase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001561-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="416" mass="46535" checksum="F2B03F6E7FF04693" modified="2016-09-07" version="1">MRRRKPTEGFILCGIFFWTIIAHLISTCLAAQLEERMEIVRKVLKEVPLIDGHNDLPWNIRKFLKNQLREFRFGEDLRDITPWSTSAWSHTDLRRLKEGMVSAQFWSAYAPCSSQHLDAVQLTLEQIDLIRRLVNLYPQHMALVTTADGIEESHRSGKLASLIGIEGGHSIGTSLGVLRTFYQLGARYLTLTHTCNTPWADCCKVDEPGRVPHIGGLSHFGTLVVTEMNRLGMIVDLSHVSVPTMLDALATSKAPVIFSHSSAHAICNSSRNVPDHVLKRIAVNGGLVMVAFYPHFVSCGEKATLKDVVAHINHIRDVAGVDHVGIGAGYDGVNLVPQGLEDVSRYPYLFAELLESERWTEEDIAKLAGRNLIRVFRQVEQVRDQLEAQGMLPIDQSIPPEDILGRSYCRYSGPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3V6</accession>
    <name>A0A182P3V6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="11">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182P3V6"/>
    <dbReference type="STRING" id="199890.A0A182P3V6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001592-RA">
        <property type="protein sequence ID" value="AEPI001592-PA"/>
        <property type="gene ID" value="AEPI001592"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001592"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001592-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="520" mass="58886" checksum="B300277729FC7F15" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3X5</accession>
    <name>A0A182P3X5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">[histone H3]-dimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="7">1.14.11.65</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60188"/>
            <dbReference type="Rhea" id="RHEA-COMP:15541"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.11.65" evidence="7"/>
    <dbReference type="STRING" id="199890.A0A182P3X5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001611-RA">
        <property type="protein sequence ID" value="AEPI001611-PA"/>
        <property type="gene ID" value="AEPI001611"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001611"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140683">
        <property type="term" value="F:histone H3K9me/H3K9me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000004">
        <property type="entry name" value="Putative lysine-specific demethylase 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="10">
        <location>
            <begin position="1394"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="580"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="662"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1048"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1113"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1048"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1114"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1132"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001611-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1661" mass="186131" checksum="8B36D5885CB2E568" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P421</accession>
    <name>A0A182P421_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KEAP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P421"/>
    <dbReference type="STRING" id="199890.A0A182P421"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001657-RA">
        <property type="protein sequence ID" value="AEPI001657-PA"/>
        <property type="gene ID" value="AEPI001657"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001657"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000024">
        <property type="entry name" value="Kelch-like ECH-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF401">
        <property type="entry name" value="FI11917P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="101"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="638"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="833"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="673"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="800"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001657-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="968" mass="104113" checksum="8BB1F2EF2B29C181" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P455</accession>
    <name>A0A182P455_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="5">Glu-AdT subunit A</shortName>
            <ecNumber evidence="5">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GatA</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182P455"/>
    <dbReference type="STRING" id="199890.A0A182P455"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001691-RA">
        <property type="protein sequence ID" value="AEPI001691-PA"/>
        <property type="gene ID" value="AEPI001691"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001691"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001691-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="491" mass="53737" checksum="813C52357A4CF12E" modified="2016-09-07" version="1">MNRLPLRARVLSECFRSKSVDPVTATEQCLAHIESHKHLNAFVRVSSAKALEQAKHSKDRYDANKQKSVLDGVTIAVKDNFCTNGIHTTCASRMLQNFVPTYDATVVERLQAHGAIIVGKTNLDQFGMGSGCIDSIFGPTRNSWSEDLGGDRFRIAGGSSGGSAVAVAAGLCYAALGSDTGGSTRNPASYCGIVGLKPTYGLVSRHGLIPLVNSMDVPGIMARTIDDCTSVLNVIAGPDPLDSTTVKRPFQSMDLDKQISLKGLRIGIPIEYHCDGLDKEVLETWTVVADMLESAGAAVTAVSLPNTASSIFVYSILNQCEVASNMSRYDGIEYGHRSQEDSSTEQLYARTRAEGFNGVVKNRILSGNYFLLRENYDKYFQKALKVRRLIADDFVRAFKEVDVLLTPTTLSDAPLYKDFVQSNNRDQCAVQDFCTQSANMAGIPALSIPVRLSSRRLPISLQLMGDNFTERRLLQIGSWIEKEVDFIGNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4H4</accession>
    <name>A0A182P4H4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4H4"/>
    <dbReference type="STRING" id="199890.A0A182P4H4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001810-RA">
        <property type="protein sequence ID" value="AEPI001810-PA"/>
        <property type="gene ID" value="AEPI001810"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001810"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11057">
        <property type="entry name" value="CYP313-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001810-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="515" mass="58752" checksum="D87CCA697A331B76" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4L2</accession>
    <name>A0A182P4L2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4L2"/>
    <dbReference type="STRING" id="199890.A0A182P4L2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001848-RA">
        <property type="protein sequence ID" value="AEPI001848-PA"/>
        <property type="gene ID" value="AEPI001848"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001848"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF144">
        <property type="entry name" value="CHITINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130842" description="GH18 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="25"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="390"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="765"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001848-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1145" mass="128295" checksum="506379C4FBBA4132" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4X2</accession>
    <name>A0A182P4X2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4X2"/>
    <dbReference type="STRING" id="199890.A0A182P4X2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001959-RA">
        <property type="protein sequence ID" value="AEPI001959-PA"/>
        <property type="gene ID" value="AEPI001959"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001959"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130902" evidence="1">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001959-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="75" mass="8208" checksum="ABAC04532A50A08E" modified="2016-09-07" version="1">MLSAAVIVVMAMLIVGPQPAAANDSQNINRLLNNQVIVSRQIMCVLEKSPCDQLGRQLKGSYRRHHAAIDVRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P540</accession>
    <name>A0A182P540_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P540"/>
    <dbReference type="STRING" id="199890.A0A182P540"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002027-RA">
        <property type="protein sequence ID" value="AEPI002027-PA"/>
        <property type="gene ID" value="AEPI002027"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002027"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030865">
        <property type="term" value="P:cortical cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21505">
        <property type="entry name" value="PPP2R3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000091">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.220:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041534">
        <property type="entry name" value="EF-hand_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039865">
        <property type="entry name" value="PPP2R3C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PP2A regulatory subunit B'' EF-hand" evidence="10">
        <location>
            <begin position="183"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002027-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="452" mass="52410" checksum="CECC436DFFD2F60B" modified="2016-09-07" version="1">MNLRHQHPSKTDDEIEDILYQKYRAQLAGSSKTSSPAQPPEQTQNDALTDDTYRYIPRFHFELPKSADSLAQKLREEARTLFLQKRSKELLDNAEFKLLWSLLEKHHTPPLVGEEQYINYESYCKVGVIAGEKFRRYLTATTFARLLASSANPGKISVISLFNYTMRKVWLQQTRIGLSLYDYTGQGFLSESDMESYILELIPTFPQLEGLEKSFHSFYVCTTVRKFFFFLDPLRTGRIRIRDVLTCSFLDDLLELRDEEIPKDAQELNWFSAPSALSVYGHYLNLDKDHNGMLSKKELIGYGSGTLTPIFLDRVFAECLTYDGEMDYKTYLDFVLALENRGEPQSLHYLFRILDVEHKGYLTAFTLNYFFKGIQEELSAHRAEPINFDDVKDEIFDMVKPADPTRITLKDLIRCGHGETVVSILIEFHKFWAYENREVMVTSTASDDTHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5S3</accession>
    <name>A0A182P5S3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5S3"/>
    <dbReference type="STRING" id="199890.A0A182P5S3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002264-RA">
        <property type="protein sequence ID" value="AEPI002264-PA"/>
        <property type="gene ID" value="AEPI002264"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002264"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF11">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="157"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002264-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="337" mass="37918" checksum="840EE50C8B3E610C" modified="2016-09-07" version="1">MCTRTPRCCWIGGMPGWRWEMLCYRCVCFLYVLAVLGIVILPAPVESGCRRLVRKPCEAICVRTVAQESNNSPNGRLQHPIGTNVPDSGERMGNVSLPHLPTVGGWTCELRIVAIMPANTSVQASLPRVQPVLEKAEGFIRREGIIPADVAIRWIPFDDRCEQARATVMAMDGTGSDYCGHLILGPSCDFALAPVARIARYIYNDGIPVITGAGYTFDFEEPKTHCENEFHMLIRTGLVSFKRMAFFMIDIIRHFNWDRVVYFYDRQSYYNVAGPQTGHLLMNTMAEFFRHENITYSPFSTDSARTNLTESLKEKVGLNYASKYKLTSCGMGDKRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5X5</accession>
    <name>A0A182P5X5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5X5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002316-RA">
        <property type="protein sequence ID" value="AEPI002316-PA"/>
        <property type="gene ID" value="AEPI002316"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002316"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002316-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="74" mass="8309" checksum="07AEE7F1C6F54143" modified="2016-09-07" version="1">MACNLAAGEASLRVALSVKERMAMMKLRPLIAPDNWSTCLTTFLNIAVLDFNYNMINSVQMQTFEGLNILQQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P628</accession>
    <name>A0A182P628_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P628"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002371-RA">
        <property type="protein sequence ID" value="AEPI002371-PA"/>
        <property type="gene ID" value="AEPI002371"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002371"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="746"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="807"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="906"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="96"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="433"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="813"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1096"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002371-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1356" mass="150618" checksum="DCE8C599A6FFEEAF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P641</accession>
    <name>A0A182P641_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P641"/>
    <dbReference type="STRING" id="199890.A0A182P641"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002389-RA">
        <property type="protein sequence ID" value="AEPI002389-PA"/>
        <property type="gene ID" value="AEPI002389"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002389"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="7">
        <location>
            <begin position="346"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002389-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="690" mass="76442" checksum="B7D03A5B24CB3542" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6M6</accession>
    <name>A0A182P6M6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor IIA subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6M6"/>
    <dbReference type="STRING" id="199890.A0A182P6M6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002574-RA">
        <property type="protein sequence ID" value="AEPI002574-PA"/>
        <property type="gene ID" value="AEPI002574"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002574"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.100:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000002">
        <property type="entry name" value="Transcription initiation factor IIA subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002574-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="53378" checksum="60B14C2C896E4073" modified="2016-09-07" version="1">MSLSQTSVLKVYTTVIDDVIAGVRDAFLDEGVDEQVLQEMKQVWTSKLLACKAIESTPENQDQPPAAAGNNAKTNGTKKSKAATAAAAAASASAASNNQQENGKANNNTKANPELKNASVPSLVPAGNAQPAAATNQNASAASGTTTSTTVANTAPVATAGAGTATAPQQQQQQNAPAAVVAALDPNKLVAIQITLPAQPNVPNSQPRVLTIQVPASALQENQLQHVLTSPIISSIMPLPPHIASTVLQQHVNAYLQNLSLNTVPIQKQLDGACDDDDDLKVDVASVVISPISYQLVELFPNAPLERYRLDRQLISALVTAGQNTSTTAAKESNEPIASSSSSSSSNRSGAVRSKAMAAARNSRRRHPFKAVRKTTTPVSGQEQALSFQICSSLQLDGAVDTSDEEGSDISDDNIVDDDDEDLDKEEEDDLEAEGGAEEEPLNSEDDVTDEDASDLFDTDNVVVCQYDKITRSRNKWKFYLKDGIMHIGGKDYVFQKSNGDAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6N1</accession>
    <name>A0A182P6N1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6N1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002579-RA">
        <property type="protein sequence ID" value="AEPI002579-PA"/>
        <property type="gene ID" value="AEPI002579"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002579"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002579-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="100" mass="10449" checksum="8E35653EAFD2EE7D" modified="2016-09-07" version="1">MSSAPPVHVLEAIHAFVAKLGIREPRLTVSSGSRNGDSYSGDVYRIVIAPGSRDIEDFENNNNTNGSIRGVVGAKPTTIVVDANGNEEDGGEGGKLLNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6N7</accession>
    <name>A0A182P6N7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Asparagine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P6N7"/>
    <dbReference type="STRING" id="199890.A0A182P6N7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002585-RA">
        <property type="protein sequence ID" value="AEPI002585-PA"/>
        <property type="gene ID" value="AEPI002585"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002585"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000151">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000040">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="251"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002585-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="553" mass="63634" checksum="B9ED94C161DDF84A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6X3</accession>
    <name>A0A182P6X3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6X3"/>
    <dbReference type="STRING" id="199890.A0A182P6X3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002673-RA">
        <property type="protein sequence ID" value="AEPI002673-PA"/>
        <property type="gene ID" value="AEPI002673"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002673"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF249">
        <property type="entry name" value="SOL NARAE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002673-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="154" mass="17724" checksum="1E0CACDAF1668609" modified="2016-09-07" version="1">MGLTRTEGSIGHELVIKPVPTDISQAEDGSVHHVIYKRKAHEEHNDQFSDYAFMEPDRLQKRFRTKRSPQAYYKSSRAIDRTIYPEILVIVDYDGYRLHGGDNVQVKRYFVSFWNGVDLRYRLLKGPKIRISIAGIIISRALVPKILLPKIATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7L5</accession>
    <name>A0A182P7L5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7L5"/>
    <dbReference type="STRING" id="199890.A0A182P7L5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002918-RA">
        <property type="protein sequence ID" value="AEPI002918-PA"/>
        <property type="gene ID" value="AEPI002918"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002918"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005374">
        <property type="entry name" value="BBLN_eukaryota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34344:SF1">
        <property type="entry name" value="BUBLIN COILED-COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34344">
        <property type="entry name" value="UPF0184 PROTEIN C9ORF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03670">
        <property type="entry name" value="UPF0184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002918-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="115" mass="12640" checksum="9F601C81C3155D1E" modified="2016-09-07" version="1">MPPEPKEMKPGQEKTEEVASTSADESDTPATGDEEIDLEGASEEILELNDRLDSLSTVLDSIEQHNDNLRAQILQLLDSQRETLKSFKEENSRMAEKGQGTAEPPDGGPEPMQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7U0</accession>
    <name>A0A182P7U0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial</fullName>
            <ecNumber evidence="6">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182P7U0"/>
    <dbReference type="STRING" id="199890.A0A182P7U0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002993-RA">
        <property type="protein sequence ID" value="AEPI002993-PA"/>
        <property type="gene ID" value="AEPI002993"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002993"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000035">
        <property type="entry name" value="Putative lipoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010925">
        <property type="entry name" value="PRK14345.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="10">
        <location>
            <begin position="46"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="90"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="9">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002993-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="243" mass="27491" checksum="022EAAF654B62BEF" modified="2016-09-07" version="1">MSRLVHVLRAGRLPYQRALQLQQTIANQLLHQGKQPSLPVGAALQPPYRHVLILTEHDPVYTIGIRTRGYDEAEEQRLRALGAEFVRTNRGGLITFHGPGQLVAYPILNLKHFQPSVRWYVCHLERTIIELCRRYGLQAQTTADTGVWIDDRKICAMGIHASRYVTTHGLALNCDIDLSWFRHIVPCGLVGKSVTSLVQELARPELGVDNVTDEFLDCFRQTLQCDLTPLDEAARNELMCELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7X7</accession>
    <name>A0A182P7X7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182P7X7"/>
    <dbReference type="STRING" id="199890.A0A182P7X7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003030-RA">
        <property type="protein sequence ID" value="AEPI003030-PA"/>
        <property type="gene ID" value="AEPI003030"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003030"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF15">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="6">
        <location>
            <begin position="284"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003030-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="556" mass="61756" checksum="5EA84D90C06228FB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7Z8</accession>
    <name>A0A182P7Z8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoporin-like protein 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7Z8"/>
    <dbReference type="STRING" id="199890.A0A182P7Z8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003051-RA">
        <property type="protein sequence ID" value="AEPI003051-PA"/>
        <property type="gene ID" value="AEPI003051"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003051"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051767">
        <property type="entry name" value="Nucleoporin_NUP42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527">
        <property type="entry name" value="NUCLEOPORIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003051-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="431" mass="43855" checksum="AA117CF1C25F91CF" modified="2016-09-07" version="1">MVLCMYFLNNSCRFGSRCNNEHIDIGSIVKNEVDVTLKGNQWPLSCFGPFKERICIPNFIEDQSFEEIRMMYLEAKMQNNIPAHQMQLAQMINDAKAKMQCLTTMNRDVLNTLVEIYNQQESSAKPPNQAQLNPFASIGSGGSNAPASSIFGGSTTGNAFGSAGFGSAGAAVNANTGTASSIFGGGSIGGQPAQPVGSIFGTAASTTNNIFAKPAQQTNAGNIFGMSQQPNPVFGGPAVMGGGLFGSVQQNAAPMFGGATPANPSAGGNLFTSAATNAFGQPSGGTGVFGGGSGMFGNNAATTAPATGGFGTVAAQPQQAGGLFNSVPFGGSAASNAPSFGAFGSTMQSAQPANVPSSQNLFLPTPTANPFGTSLGGSAFGAPAQAATIPQSATMYSSMEKITVENLAAFKADTFQLGRIPTVPPPKELCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P849</accession>
    <name>A0A182P849_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">coq3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182P849"/>
    <dbReference type="STRING" id="199890.A0A182P849"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003102-RA">
        <property type="protein sequence ID" value="AEPI003102-PA"/>
        <property type="gene ID" value="AEPI003102"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003102"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003102-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="295" mass="33815" checksum="2A60A6B707358CB2" modified="2016-09-07" version="1">MEGRDSVMQSKYVIIFFLVLSFFRFVLVKWVEKTSIAFLSLIEGLTFKGTTEDNIATFDQLSKHWWEPNGPMILLHRLNKLRVPMVVEGLIKVGKLDRKERYKTDSLKGFNILDVGCGGGIYTEALAKLHANVVGIDPARHLIEVAKAHAQAQSDIKDRCMYYEQSLEEHWQSAVGKYDVVVLSETIEHVEDKSALLQHVAEVLKPGGSIFISTWNKTNYAWLLAVVVLENVLKRLPKGSHEYDKFISPEKTEAMLEAYGCRTIEQRPFYLKFWESEWIWVPFNGFTYALHAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8N8</accession>
    <name>A0A182P8N8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P8N8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003291-RA">
        <property type="protein sequence ID" value="AEPI003291-PA"/>
        <property type="gene ID" value="AEPI003291"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003291"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000072">
        <property type="entry name" value="Cyclic nucleotide gated channel beta 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000004">
        <property type="entry name" value="Cyclic nucleotide-gated olfactory channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000058">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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    <sequence length="1764" mass="196558" checksum="106CCC84B06E7E32" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P982</accession>
    <name>A0A182P982_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial</fullName>
            <ecNumber evidence="4">1.2.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Malonate-semialdehyde dehydrogenase [acylating]</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20804"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:20805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>3-oxopropanoate + NAD(+) + CoA + H2O = hydrogencarbonate + acetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76615"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
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            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:76616"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AEPI003486-PA"/>
        <property type="gene ID" value="AEPI003486"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
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        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="14">
        <location>
            <begin position="35"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00009986"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00011881"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003486-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="521" mass="56730" checksum="F5152DB859A0ECCF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAM9</accession>
    <name>A0A182PAM9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAM9"/>
    <dbReference type="STRING" id="199890.A0A182PAM9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003984-RA">
        <property type="protein sequence ID" value="AEPI003984-PA"/>
        <property type="gene ID" value="AEPI003984"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003984"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF57">
        <property type="entry name" value="VILLIN-LIKE PROTEIN QUAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HP" evidence="3">
        <location>
            <begin position="801"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003984-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="866" mass="98123" checksum="45E15DBED1B0F47A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAV1</accession>
    <name>A0A182PAV1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphoglucomutase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAV1"/>
    <dbReference type="STRING" id="199890.A0A182PAV1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004056-RA">
        <property type="protein sequence ID" value="AEPI004056-PA"/>
        <property type="gene ID" value="AEPI004056"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004056"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="50"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="219"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="364"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004056-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="68881" checksum="D477EF7342A98FFD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC97</accession>
    <name>A0A182PC97_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC97"/>
    <dbReference type="STRING" id="199890.A0A182PC97"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004552-RA">
        <property type="protein sequence ID" value="AEPI004552-PA"/>
        <property type="gene ID" value="AEPI004552"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004552"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004552-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="326" mass="37435" checksum="FA1DE37623E3CE7A" modified="2016-09-07" version="1">MASLRELTSKKSARPTIHVAIHPNLGTPPTGASTPSDGTDYKSIFFNEISQIMRGYGDCEKPLRESVLLVEKIVLQQLRGIMQEAIDHAMSRPNSPTLSRRDFEYIMRKNQVRVARLQKYFRDMALMKKRLKDLCGGRYPHLNLGPSSETSDDDSDREAPEKYDEEKARRLFRADRISQILTGRQYEEYIAARRTSFMHRNTEVMKSRMRQWLNIPEDVNITQSCLLTLAYLAHETIAVLVDFCILTRLNSANRAVDPYSRVTSSGKSYNMLHACPEVSQGRGLDGVKPITPQEITEAMRRHRQMAMRISGRYRNALNFKTPYLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCL1</accession>
    <name>A0A182PCL1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat GAD-1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCL1"/>
    <dbReference type="STRING" id="199890.A0A182PCL1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004666-RA">
        <property type="protein sequence ID" value="AEPI004666-PA"/>
        <property type="gene ID" value="AEPI004666"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004666"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001228">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001038">
        <property type="entry name" value="WD repeat domain 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004666-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="656" mass="72547" checksum="337CE5B53B0608AE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCS2</accession>
    <name>A0A182PCS2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCS2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004727-RA">
        <property type="protein sequence ID" value="AEPI004727-PA"/>
        <property type="gene ID" value="AEPI004727"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004727"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004727-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="95" mass="10850" checksum="5FD4BB73F51C54FB" modified="2016-09-07" version="1">MVRSWVRTGRQLQCPRKLVRNTRRSNSLSQASITEVNRRQTIRGRSRTNEANRRTAISVIGTSQYRSVHLRISCRASRVIVAIIIVHVKPVIGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCY7</accession>
    <name>A0A182PCY7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCY7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004792-RA">
        <property type="protein sequence ID" value="AEPI004792-PA"/>
        <property type="gene ID" value="AEPI004792"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004792"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004792-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="347" mass="38964" checksum="C258252A1087E0BF" modified="2016-09-07" version="1">MRSRTELVTNTLDGSDFDEETDFEDSEEDWKPDKGDPKAMKRKTRDILTGTLSAKRGGRGNGSKRGRKPGGKGRGTPRKRFFEDDEDDDDDDDDEEDEEDSRFDSEASGTSTPPVPKRGRKSSSGTPHGRKSNSSSSSSSKTSPSTSKSGNVKRNRYSDAELKGKPIQRKVGNTPGSVPDKSGYLKLYVCRADLEEGIRNNLKVCLWRRDGSSLLQKYFRDKSVDASTPQYTSSMVYSCWEDRRADEYMEVKVRCIEHAKQLRVQIMDVEAIECRAREEYQKYIEKYGKVSSGGSSSERLNGENMTGSGSSARKTHDSEGEEEYEEAEEPNDELEEGERSDVPSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCZ2</accession>
    <name>A0A182PCZ2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCZ2"/>
    <dbReference type="STRING" id="199890.A0A182PCZ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004797-RA">
        <property type="protein sequence ID" value="AEPI004797-PA"/>
        <property type="gene ID" value="AEPI004797"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004797"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004797-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="248" mass="27809" checksum="3AAB7BCBA49F2A50" modified="2016-09-07" version="1">MYNQTYNGGATYGVGYGAEYTQQHQHYYYQQQQHTQQQQQMIAGIMGYYPSEAAAMFYNPYSYGQPTARQQFAQQQAQLDYQLTPALYLLNQQAELLQKSLVKAPLSKKSGETGKPQPVQRKQRGPYKRRTNKTLSPTVSPAPEFVTDAAERLSSSDLAGSNNRSVGTPISIDLTGSSNNTTSTTDSVQQQTQRKRKSDSFLELEQQQTNKHSRTLLNQRKQSIFRDVALMAVSSCTNNTTQSETSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD67</accession>
    <name>A0A182PD67_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PD67"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004872-RA">
        <property type="protein sequence ID" value="AEPI004872-PA"/>
        <property type="gene ID" value="AEPI004872"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004872"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="6">
        <location>
            <begin position="269"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="638"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="713"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="713"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004872-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1254" mass="139144" checksum="0ABA4AFE25DFF6C3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDC1</accession>
    <name>A0A182PDC1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaminyl-peptide cyclotransferase</fullName>
            <ecNumber evidence="4">2.3.2.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a glutaminyl-peptide cyclotransferase. Responsible for the biosynthesis of pyroglutamyl peptides. Might be more efficient in the conversion of tri and tetrapeptides in vitro. Might have a relative preference for substrates containing hydrophobic amino acids in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23652"/>
            <dbReference type="Rhea" id="RHEA-COMP:11736"/>
            <dbReference type="Rhea" id="RHEA-COMP:11846"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="ChEBI" id="CHEBI:87215"/>
            <dbReference type="EC" id="2.3.2.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutaminyl-peptide cyclotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.5" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PDC1"/>
    <dbReference type="STRING" id="199890.A0A182PDC1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004926-RA">
        <property type="protein sequence ID" value="AEPI004926-PA"/>
        <property type="gene ID" value="AEPI004926"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004926"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000029">
        <property type="entry name" value="Glutaminyl-peptide cyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131275" description="Glutaminyl-peptide cyclotransferase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="14">
        <location>
            <begin position="107"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004926-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="340" mass="38168" checksum="660C028F8E6AEF57" modified="2016-09-07" version="1">MPRVHITVLLLAIAFLSTNGQNGNVKNTQKHTATTVSASGLHQLATDPMTLLSPALENLLVERVVGSTGHENVKNYIVQQMRQLGYTVELDEFDETVPILGKLRFANIIASLNPNAERNLVLACHYDSKYFPGQRFIGATDSAVPCAMLVTMAAMLAPHLESAKARTDLSLQFIFFDGEEAFKDWNAQDSIYGARHLAARMEQDGTLTKMDMLVLLDLLGTPEPNFYSYFQATENWYVQLISVERRLDELGHLENYSTSSVSPAQKSIAYFRPHSFTAHIEDDHIPFLRRGVPVLHIIPSPFPEVWHKLEDNGDIVDVPTVRNMVRIFAVFVLEYLNVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDC3</accession>
    <name>A0A182PDC3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone acetyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182PDC3"/>
    <dbReference type="STRING" id="199890.A0A182PDC3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004928-RA">
        <property type="protein sequence ID" value="AEPI004928-PA"/>
        <property type="gene ID" value="AEPI004928"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004928"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036409">
        <property type="term" value="C:histone H3-K14 acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000003">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="12">
        <location>
            <begin position="625"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="32"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="562"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004928-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="761" mass="81830" checksum="8060A4894C314A7D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDQ5</accession>
    <name>A0A182PDQ5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDQ5"/>
    <dbReference type="STRING" id="199890.A0A182PDQ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005060-RA">
        <property type="protein sequence ID" value="AEPI005060-PA"/>
        <property type="gene ID" value="AEPI005060"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005060"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055269">
        <property type="entry name" value="Alpha-crystallin/HSP_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF34">
        <property type="entry name" value="PROTEIN LETHAL(2)ESSENTIAL FOR LIFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036514">
        <property type="entry name" value="Sm_HSP_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="57"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005060-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="175" mass="20572" checksum="E5517CA17657093E" modified="2016-09-07" version="1">MSLVPVQYRTWWDDWDLPLYTRVLEKSITQEVLGADDYWRVPPLAPVRWSSLYRPWRYFSLRDVGAKVDTDRDRFQIELDVHQFLPHEVTVRRTDKYVTIEGKHEEKRDEQGYVARQFSRRYLVPIGYDANLIVSSLSSDGILTVTAPRIGLPAPKVEKYVPIWHTGKPAIEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE78</accession>
    <name>A0A182PE78_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PE78"/>
    <dbReference type="STRING" id="199890.A0A182PE78"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005233-RA">
        <property type="protein sequence ID" value="AEPI005233-PA"/>
        <property type="gene ID" value="AEPI005233"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005233"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07623">
        <property type="entry name" value="BAR_SNX1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06859">
        <property type="entry name" value="PX_SNX1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000047">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000012">
        <property type="entry name" value="Sorting nexin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="65"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="361"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005233-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="451" mass="51499" checksum="9DB743D17ED5BE51" modified="2016-09-07" version="1">MDTNGTLDNGDAEQTQKQHTQPAFDNVDITSPDDENENDIFESAIQQEPLSPVLEDVPTDEAGDTFIEIVVADPQKVGDGMGSYLAYKVSTKTNILKFKKRQFFTMRRFSDFLGLHDLLVSKYLRMGRIIPPAPEKNIIGTTKVRMGSQPQAEAGTGVNLEWIENRRASLERFLNRVAQHPILCQDTDFVNFLESDQELPRAVNTAALSGAGVMRLFNKVGETVNKITYKMDENDPWFNDKINEVETIDAHMQKLHSAIKALVSHRKELATLTGGVAKSAALLSTCEEHTGLSQALSQLADVEEKVELLRSEQANSDLYILSETIKDYIGLFGAIKDVFHERVKVFQNWQHAQMQLTKKRENKAKLELQDRRDKLEFAQKEVEEWEGKVQRCQKEFDNISSEIKKEMERFELARARDFKSTIIKYLEDQMAHQQQQMRYWEAIVPVARDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGE0</accession>
    <name>A0A182PGE0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGE0"/>
    <dbReference type="STRING" id="199890.A0A182PGE0"/>
    <dbReference type="ESTHER" id="9dipt-a0a182pge0">
        <property type="family name" value="ABHD12-PHARC"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="AEPI005999-RA">
        <property type="protein sequence ID" value="AEPI005999-PA"/>
        <property type="gene ID" value="AEPI005999"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005999"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="194"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005999-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="424" mass="48721" checksum="1B7DDEA5DCC96764" modified="2016-09-07" version="1">MAMFDLDRLITDFFKTTVLPGIAIGLWLTDLIGPVVCGILVLVFLVVFVILPIIFKLSFALQKSILFLTFINYPPNLDLKRPEKSGLYATRNFYIQHHDQEEDIDVKIAVWHVLPNDLVRRYPKELQVEEHTIPNKTLPTIDGSTSHGGTILSNGDPSDRYRRIEKILRADDFKLTDEQAQKNLFEEALRASTNDVVLYLHGNTASRGAPHRVELYQTLRALNYHVIAMDYRGYGDSANVSPTEQGVVYDALAVYQYITSITNNPVYLWGHSLGTGVSTHLLSLLAEMSLPGPRAVVLESPFNNIKEEICAHPFSKLYRHLPWFDFLISKPMYNNNLRFESDQHIAEFRQPVLILHAEDDLVVPFDLGYKLYRKALDTRGKSWGPIEFHRFERSSHYGHKYICRAPNLPEIVVRFFHAYRDAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGL1</accession>
    <name>A0A182PGL1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGL1"/>
    <dbReference type="STRING" id="199890.A0A182PGL1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006070-RA">
        <property type="protein sequence ID" value="AEPI006070-PA"/>
        <property type="gene ID" value="AEPI006070"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006070"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="35"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="120"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="1062"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="660"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="773"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="926"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="724"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="823"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="941"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="984"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006070-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1218" mass="140964" checksum="E44F711198690760" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGT9</accession>
    <name>A0A182PGT9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Odorant-binding protein 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGT9"/>
    <dbReference type="SMR" id="A0A182PGT9"/>
    <dbReference type="STRING" id="199890.A0A182PGT9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006148-RA">
        <property type="protein sequence ID" value="AEPI006148-PA"/>
        <property type="gene ID" value="AEPI006148"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006148"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF4">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 69A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006148-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17513" checksum="2382367B7505E891" modified="2016-09-07" version="1">MNNPVAIFVLLTVYIVLSAPILLFILQQSFEIPERYKKPAKMLHEICIAESGASEEQLRTCLDGTVPSDPAAKCYIHCLFDKIDVVDEDTGRIWLDRLLYILPDDVKEAVTHLTRECNHIETPDKCDTAYETVKCYFNAHDEVIKFCHLLVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGV5</accession>
    <name>A0A182PGV5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGV5"/>
    <dbReference type="STRING" id="199890.A0A182PGV5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006164-RA">
        <property type="protein sequence ID" value="AEPI006164-PA"/>
        <property type="gene ID" value="AEPI006164"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006164"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070842">
        <property type="term" value="P:aggresome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053003">
        <property type="entry name" value="TRIM_RBCC_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36754">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36754:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="321"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006164-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="71639" checksum="E4D1B7D4E0415CA1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHH5</accession>
    <name>A0A182PHH5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHH5"/>
    <dbReference type="STRING" id="199890.A0A182PHH5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006384-RA">
        <property type="protein sequence ID" value="AEPI006384-PA"/>
        <property type="gene ID" value="AEPI006384"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006384"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131307" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="54"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006384-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="555" mass="60256" checksum="32E32E0FE32D336A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHN2</accession>
    <name>A0A182PHN2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nitric oxide synthase-interacting protein homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NOSIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHN2"/>
    <dbReference type="STRING" id="199890.A0A182PHN2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006441-RA">
        <property type="protein sequence ID" value="AEPI006441-PA"/>
        <property type="gene ID" value="AEPI006441"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006441"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16661">
        <property type="entry name" value="RING-Ubox1_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16662">
        <property type="entry name" value="RING-Ubox2_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000240">
        <property type="entry name" value="Nitric oxide synthase-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000251">
        <property type="entry name" value="Nitric oxide synthase-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitric oxide synthase-interacting protein zinc-finger" evidence="8">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006441-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="292" mass="32629" checksum="642A85B395F686E9" modified="2016-09-07" version="1">MTRHARNCTAGAVYTYHEKKKDAANSGFGTTSRRIGKDSVKSFDCCSLTLQPCRNPVITKDGYLFDKEAILTYIISKKNEYSRKMKEYEKQVKQDEEEETAKANAEQQKKLDKFISTEKNIVSSKAVKANEQPSTSGAISNVSLGKRKELPSFWVPSQTPAAKVSRIEKPDSKIYCPVSNKLLKAKDLIDVKFTLVKDPSDKKSLIAKENRYMCAVTHDILSNSVPCAVLKPTGDVVTMECIEKIIKKDMIHPLTNEKLSESDIIPLQRGGTGFATTNEKLEAKEQKPCLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIU5</accession>
    <name>A0A182PIU5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIU5"/>
    <dbReference type="STRING" id="199890.A0A182PIU5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006858-RA">
        <property type="protein sequence ID" value="AEPI006858-PA"/>
        <property type="gene ID" value="AEPI006858"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006858"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006858-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="152" mass="15624" checksum="C05DECCA65D597EC" modified="2016-09-07" version="1">MAKSEAYLTQRNTCTAYYRIVVHSDSGDEELAPRTGPCALPRSTVAGGGGGGGGGGGGLVGGYPAGNMSLNGRELVKQPPPPADYNQSVLTMQKSVTITVTPQRSNSMDLLNFEEKRQLIASSLSLSDILHVSPAAAHVAKEVAASTVIGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJA3</accession>
    <name>A0A182PJA3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homooctamer; active form. Homohexamer; low activity form.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 17"/>
    <dbReference type="AlphaFoldDB" id="A0A182PJA3"/>
    <dbReference type="STRING" id="199890.A0A182PJA3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007017-RA">
        <property type="protein sequence ID" value="AEPI007017-PA"/>
        <property type="gene ID" value="AEPI007017"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007017"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007017-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="331" mass="36320" checksum="4DDD507F7627835A" modified="2016-09-07" version="1">MSSARLHSSIFHPTLRKLQCQDVTIEAHNLMYPVFLVDDDEAVQPIPSMPGVARYGITTFLAHLEPLVAKGLQSILLFGVIDEKPKDANGSGADSANNPVIRALPRLRETFPDLLIACDVCLCPYTHHGHCGILTEDGLIDNGPSIKRIAEIALAYAQAGAHIVAPSDMMDNRIHAIKQALRANNLENRCSVLSYSVKFASGFYGPFRDAAKSAPAFGDRKCYQLPPGSKGIAKRAAKRDVEEGADMLMVKPGMAYLDIVKQVKDDYPELPLFIYQVSGEYSMLLNAGKIGAFDLKTVLWEVLVGMRRAGADCIISYFTPIVLDWLKEQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJQ5</accession>
    <name>A0A182PJQ5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">c-SKI SMAD4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJQ5"/>
    <dbReference type="STRING" id="199890.A0A182PJQ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007169-RA">
        <property type="protein sequence ID" value="AEPI007169-PA"/>
        <property type="gene ID" value="AEPI007169"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007169"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21079">
        <property type="entry name" value="DHD_Ski_Sno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.20:FF:000002">
        <property type="entry name" value="SKI-like oncogene a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF25">
        <property type="entry name" value="SNO ONCOGENE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01046">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="c-SKI SMAD4-binding" evidence="3">
        <location>
            <begin position="217"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007169-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="340" mass="38031" checksum="AC4A086E58A50C58" modified="2016-09-07" version="1">MTEYVPPHVISVLKTYQDKAPRSLHGPGLSLVHPSKASSAIVGRADTPDQHSGAHSQHNPLHHGGEHGASGEEEGAQQPAPRQQQPMGPPVPGVPIMTTPDPDCGIVQMTVLEGKRIGCFLLGGETRLCLPQIFNNILTDFSVEQINRSIQELMIYLYNCTDQQLAEFKRANIIPDTAKTCGLITRTNAERLCSSLLHQAHELRPRLKGGGGLLSGSFRVYHRCFGRGEGLFLPELYSYDEPTCIECAECRGLFSPQKFVCHQHEPQEIRTCHWGFNSSNWRSYIHVAESEKNRDEHAQVLDKIWLKEREIEQELECGRAFWIARRKVIVLLLLPCSVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJV8</accession>
    <name>A0A182PJV8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJV8"/>
    <dbReference type="STRING" id="199890.A0A182PJV8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007224-RA">
        <property type="protein sequence ID" value="AEPI007224-PA"/>
        <property type="gene ID" value="AEPI007224"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007224"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000001">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
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            <begin position="114"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007224-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="521" mass="58017" checksum="6D2D35E9C9925E16" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK47</accession>
    <name>A0A182PK47_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AEPI007313"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007313"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021785">
        <property type="entry name" value="DUF3350"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF16">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11830">
        <property type="entry name" value="DUF3350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="730"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1249"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1014"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1259"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007313-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1281" mass="142483" checksum="16D54F4DEC689C23" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKP8</accession>
    <name>A0A182PKP8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKP8"/>
    <dbReference type="STRING" id="199890.A0A182PKP8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007515-RA">
        <property type="protein sequence ID" value="AEPI007515-PA"/>
        <property type="gene ID" value="AEPI007515"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007515"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF213">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="85"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007515-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="292" mass="33660" checksum="5E54C706C1AF56DA" modified="2016-09-07" version="1">MKSIQFANTEEQYRKYADELRSADVQRLAEWAKGQPHLPPITELELMLFLHSNYYDLEAAQRTIECYYSFRTSCKNLFGSRNLEKAAIHTAMDVLDLVILPELTPEGYRVMLAKIVDPDASKFSLSALLTFALMCVDILIWEEGCNNGSILIIDMDGIHLGHLPKLGIFTLKDLLYFIQEGLPIRLKGLHLANVVPFIDRIMTMIRPFMKKELLQMLHLHTKMHTLFPYIPQHLLPLDYGGMAESRKVLRDHLYNHTIECADHLASYDQLKRVDESKRIAKQRTMGNLFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL89</accession>
    <name>A0A182PL89_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PL89"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007706-RA">
        <property type="protein sequence ID" value="AEPI007706-PA"/>
        <property type="gene ID" value="AEPI007706"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007706"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF43">
        <property type="entry name" value="INNEXIN INX4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007706-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="392" mass="44996" checksum="AEAFB5253B7C2420" modified="2016-09-07" version="1">MLEFARPLLNILQIKQVNSTDLIWRLHCRVTVYLLLLASLLLSARQYFGNPIDCVVGSGTVTASTMNEFCWIMGTYISSDPNFGNVLSSPVLDSTDLVKINAKIGHVPENERSYQKYYQWVVFILALQACMFSLPNFLWKAWEAGRLQSLCDGLTTPIVPDQWKQTRKKQLISYLVADFPRLHRTYFLRYCFCTLLNFCNVLLNIALVNVIFSGFWSNYHPAVKALLSFDFPSWSRYNSQVFPKIAKCDFHFIGPSGSKQNRDGLCLLPLNVVNEKIFAFIWVWFLALLVVSLMNLLFWVVVLCSKSFRLWLLTAPLYPIRTKVMVRALDGQGIGKWFLLFQLCRNLNPMVSRELLQSVAKAKDNGRKPYRLSKGGEPDFYTDPEGFDEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM19</accession>
    <name>A0A182PM19_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase E3D</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HECT-type E3 ubiquitin transferase E3D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">UbcH10-binding protein with a HECT-like domain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2C-binding protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with UBE2C/UbcH10 (E2 ubiquitin-conjugating enzyme). In vitro, interacts with cyclin-B.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PM19"/>
    <dbReference type="STRING" id="199890.A0A182PM19"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007991-RA">
        <property type="protein sequence ID" value="AEPI007991-PA"/>
        <property type="gene ID" value="AEPI007991"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007991"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007991-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="470" mass="54737" checksum="34A663CC3ABADA54" modified="2016-09-07" version="1">MIPSTGKIDRLLIELRPRLQCANFFISFPRKFVDIESTTIELSTDRITIVMKGERERYEIRTGDYFQLHTQTLSSLVIKNRYICFRVNTNKSVFGSERLCASQENNDQNEEPTFRLACNVEPGERYRVLCSNCAGPLSDNSLSSDDPGITFNRVLELPSEQLDTDDWFCHKHDHHHHGGGVEAESSTNLTTTFEPQQGDLFYGTFYALLHRSGLQRVHVRNDRFVYCKRCLQYLGSTRKNRSSVKLWYENVHFQPAERSTTTTIPLSLFRTDDSLELFHYLVRKTVREFNFVTHLGLPPSIKLMFELRRPGLQGEVFYLLMQIMDCQLSVFRAKHKRAGSSSSESCSDDVDDCKAEHESQNVPHDGGDKEDPVRRDDEDEEDDDVFIDNAYQKHTIKLERHRAMKLMYQYEKYEEQPLFAFWREDSNVVNLELSEPMFSAAIRYLDANSSYVPECYRVNLGFCMSYLDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMA1</accession>
    <name>A0A182PMA1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182PMA1"/>
    <dbReference type="STRING" id="199890.A0A182PMA1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008074-RA">
        <property type="protein sequence ID" value="AEPI008074-PA"/>
        <property type="gene ID" value="AEPI008074"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008074"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF49">
        <property type="entry name" value="NIM1 SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="10"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="344"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008074-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="574" mass="64204" checksum="AC26EAB815D49A5C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNH3</accession>
    <name>A0A182PNH3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNH3"/>
    <dbReference type="STRING" id="199890.A0A182PNH3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008500-RA">
        <property type="protein sequence ID" value="AEPI008500-PA"/>
        <property type="gene ID" value="AEPI008500"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008500"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008500-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="106" mass="11440" checksum="517CDE4F9622D92D" modified="2016-09-07" version="1">MVGARVQETEGASLAASHAIGFCEVSVADNTPALYKAFERLLVESRARPVKPRKFSVSKMFGTLIGNNGTRQPPASQGTVVPCHKGELHKSRVMKRRQAFTATASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPA3</accession>
    <name>A0A182PPA3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPA3"/>
    <dbReference type="STRING" id="199890.A0A182PPA3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008782-RA">
        <property type="protein sequence ID" value="AEPI008782-PA"/>
        <property type="gene ID" value="AEPI008782"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008782"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000010">
        <property type="entry name" value="T-box transcription factor TBX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002070">
        <property type="entry name" value="TF_Brachyury"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF204">
        <property type="entry name" value="SPADETAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00938">
        <property type="entry name" value="BRACHYURY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008782-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="432" mass="47000" checksum="2CD21E423E04CBDE" modified="2016-09-07" version="1">MFPSMRLTVDGLDADTNYCVLLEMMPISDCRFKFSGSQWVPAGGAEPQSPQRFCLHPDSPALGTHWASQPIVFNKVKLTNNTLDNNGHVVLTSMHKYQPRIHIIRTSDPSQIPWAAQQAFVFPETEFVAVTAYQNDRITKLKIDNNPFAKGFRETGQSRCKRKMGCNTSSSSSSSSSSGAGGSVGGGGGGGSGDSGQLTDDEDRHDLHDLIKRPRSNGSPASDCTVHEGAGPPMHHPRLHHAALRPFPPSQELLMRQYNQMFNPSWMDLMLPYFARHHQPYHPHPHPHQQQHPSHHHHLQHAQPPGPFVGPVAPPVGTHITAPIVSPAHSNPDSSDLDRSSAFSVRTPQTSGSDFEPCERAAPRPDTPEGSPKPATILRPAAIRPAGSSPATSPTEVVPPHHQHQLGAVDPTDPNGDPERKINFSIASILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPI7</accession>
    <name>A0A182PPI7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">U6 snRNA-associated Sm-like protein LSm7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Interacts with TACC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPI7"/>
    <dbReference type="STRING" id="199890.A0A182PPI7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008866-RA">
        <property type="protein sequence ID" value="AEPI008866-PA"/>
        <property type="gene ID" value="AEPI008866"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008866"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000025">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="37"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008866-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="128" mass="13359" checksum="2977A35519A26935" modified="2016-09-07" version="1">MSDKKTAASGHSSGGGGGGSGGGGGGGGDNKEKRRKESILDLSKYLEKTIRVKFAGGREAAGVLKGYDPLLNLVLDNTVEFLRDPDDYKLADDTRTLGLVVCRGTSVVLICPQDGMESIQNPFIAQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPP9</accession>
    <name>A0A182PPP9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPP9"/>
    <dbReference type="STRING" id="199890.A0A182PPP9"/>
    <dbReference type="ESTHER" id="anoga-glita">
        <property type="family name" value="Gliotactin"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="AEPI008928-RA">
        <property type="protein sequence ID" value="AEPI008928-PA"/>
        <property type="gene ID" value="AEPI008928"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008928"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000156">
        <property type="entry name" value="Neuroligin-4, Y-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131583" description="Carboxylesterase type B domain-containing protein" evidence="6">
        <location>
            <begin position="31"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="732"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="180"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="805"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="905"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="922"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008928-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="971" mass="109895" checksum="DCCAC03B7764262B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ61</accession>
    <name>A0A182PQ61_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TMC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQ61"/>
    <dbReference type="STRING" id="199890.A0A182PQ61"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009091-RA">
        <property type="protein sequence ID" value="AEPI009091-PA"/>
        <property type="gene ID" value="AEPI009091"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009091"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF43">
        <property type="entry name" value="TMC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="722"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="8">
        <location>
            <begin position="539"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="826"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="828"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009091-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="861" mass="97004" checksum="99B43F52F626DE5A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQW2</accession>
    <name>A0A182PQW2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4781 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQW2"/>
    <dbReference type="STRING" id="199890.A0A182PQW2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009343-RA">
        <property type="protein sequence ID" value="AEPI009343-PA"/>
        <property type="gene ID" value="AEPI009343"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009343"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031962">
        <property type="entry name" value="DUF4781"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16013">
        <property type="entry name" value="DUF4781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4781" evidence="1">
        <location>
            <begin position="117"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009343-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="872" mass="98526" checksum="0EBA5A71D6DC290A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR87</accession>
    <name>A0A182PR87_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ApaG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PR87"/>
    <dbReference type="STRING" id="199890.A0A182PR87"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009469-RA">
        <property type="protein sequence ID" value="AEPI009469-PA"/>
        <property type="gene ID" value="AEPI009469"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009469"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003967">
        <property type="entry name" value="PRK05461.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289:SF16">
        <property type="entry name" value="POLYMERASE DELTA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApaG" evidence="2">
        <location>
            <begin position="218"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009469-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="407" mass="45509" checksum="37502F834AFD43D6" modified="2016-09-07" version="1">MSPLMSKALSLCHLRPRYNIVVRLFSVSIYYNTRLAEVGRLELPKAQGKYETGQLFLHRVFGYRGVILFPWLARVYDRDLPNQSKGNQIEGVTADATEGGAAGGGNASKEVQKKTHTFYQVLIDQRDCPYIRAQTEAVTFLGNQESSRSLYAIPGLDYVAHEDILPYSSGEQHPLQHELFDKFLAHQPDKDPPFVAQETLRAWQKKNHPWLELSDVHKETTEGIRVTVIPFYMGCRETPAASVYWWRYCIRLENLGELSVQLRERHWRIFSLSGTLETVRGRGVVGQEPILSPRLPAFQYSSHVSLQAPSGHMWGTFRMEREDGHMFDCRIPPFSLESKPDDNSGTGSIDDANTTLSPSSSKHPPSNAGVSGVGEEPTPSSTPTTTTTTSSAKPNTKNNKNDGDDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS36</accession>
    <name>A0A182PS36_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PS36"/>
    <dbReference type="STRING" id="199890.A0A182PS36"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009771-RA">
        <property type="protein sequence ID" value="AEPI009771-PA"/>
        <property type="gene ID" value="AEPI009771"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009771"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000318">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="158"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="339"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009771-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="512" mass="56154" checksum="23FBE2C8AAEA2A44" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS94</accession>
    <name>A0A182PS94_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4781 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PS94"/>
    <dbReference type="STRING" id="199890.A0A182PS94"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009829-RA">
        <property type="protein sequence ID" value="AEPI009829-PA"/>
        <property type="gene ID" value="AEPI009829"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009829"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031962">
        <property type="entry name" value="DUF4781"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21115">
        <property type="entry name" value="GH06117P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21115:SF0">
        <property type="entry name" value="GH06117P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16013">
        <property type="entry name" value="DUF4781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4781" evidence="2">
        <location>
            <begin position="134"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009829-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="644" mass="71965" checksum="46AA9F5CFD6E0815" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSS7</accession>
    <name>A0A182PSS7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSS7"/>
    <dbReference type="STRING" id="199890.A0A182PSS7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010013-RA">
        <property type="protein sequence ID" value="AEPI010013-PA"/>
        <property type="gene ID" value="AEPI010013"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010013"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="37"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010013-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="509" mass="57317" checksum="76C55561EE04B0ED" modified="2016-09-07" version="1">CGVRTSRRQPRSNVSKLSTSANFSHSSLTPFVRNPKIMHGTPTVEGQYPWQVSLELLHPSFGFIGHWCGGVLIERNWVLSAAHCIHKYVSLLKRHSIIFIYVDEFKSILISLLLLSASSDLFNLPLPALWTVVLGEYDRRTESGFEQRIPVDKIILHEKYHNFKHDLVLLKLGKPANTSPNSRVRKICLPFADFKVNSMSFDPRPTQQSKPDLNSKPAYFFDNEQSDDLNVQSAPDHEGFNESESFPEPMPLRDDNFLRHFKKSLLEASPNSRAGRSRTARYMINHLVEERLRSNRTKSVLSSAQTASSTPDAASAGRFSRRLFALDTFKPANTQQWIGRNGRRWIESPFAGNVALANNAPSNRQHYRANLNSKFGNNRRRNDKFSHAPVYYRKEPNYRTDDAINPVSPEVNGPFENFASDAQMDHVSSASGMPDTSQYVDCLATGWGKSTIDDELTDVLLQTRAPIQSSKKCEEAYGDFIKLHRGHLCAGNLDGAGGTCVVCMSVVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTC0</accession>
    <name>A0A182PTC0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PTC0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010206-RA">
        <property type="protein sequence ID" value="AEPI010206-PA"/>
        <property type="gene ID" value="AEPI010206"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010206"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031085">
        <property type="term" value="C:BLOC-3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043989">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026091">
        <property type="entry name" value="HPS4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407:SF9">
        <property type="entry name" value="BLOC-3 COMPLEX MEMBER HPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 4 PROTEIN LIGHT-EAR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19033">
        <property type="entry name" value="Intu_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU/HPS4 third Longin" evidence="3">
        <location>
            <begin position="759"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010206-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="860" mass="96209" checksum="DA7BD10288AC691E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU81</accession>
    <name>A0A182PU81_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mevalonate kinase</fullName>
            <shortName evidence="10">MK</shortName>
            <ecNumber evidence="10">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182PU81"/>
    <dbReference type="STRING" id="199890.A0A182PU81"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010517-RA">
        <property type="protein sequence ID" value="AEPI010517-PA"/>
        <property type="gene ID" value="AEPI010517"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010517"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="11">
        <location>
            <begin position="154"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="12">
        <location>
            <begin position="321"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010517-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="416" mass="44739" checksum="9D89FE064E8D735C" modified="2016-09-07" version="1">MTTIVKQFEVSAPGKVILHGEHSVVYGHPAIAGSIGLHTYLNYTALERSSASPSAQVIIEFRSLPFTATLSLDSFDAFLREVDCNEALQPDAFLEQLRSTGEFPFARFLSDSKESSCLEDTSSKERMSLGSTLYIMNRVLRSEGVTTLDPSTIGEGGFRLSLYSEMSIGAGLGSSASYGVCLAAGAYQLARILKREATADHPPKLGEDVLKKIYQWSFDSEIIMHVKPSGIDNEIATNGGMVRFRRGCGVNKIITLRRPVNVLIVDTGVSRSTANLVTIAAKRLELFPRTVGPILQAMGGLVDEAIALFEGDQDPDTVYERLSTLVSINNNLLRSLGVSHPALEKIFAIAERAGFASKLTGAGGGGCAFVLLPTAFRELDSFRELMDALKEAGLRSIETTVGTGAGVTLSYPADDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUA1</accession>
    <name>A0A182PUA1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUA1"/>
    <dbReference type="STRING" id="199890.A0A182PUA1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010537-RA">
        <property type="protein sequence ID" value="AEPI010537-PA"/>
        <property type="gene ID" value="AEPI010537"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010537"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000290">
        <property type="entry name" value="GG11888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="677"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="7">
        <location>
            <begin position="354"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="8">
        <location>
            <begin position="526"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010537-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="819" mass="92067" checksum="CB3E771685728145" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUI8</accession>
    <name>A0A182PUI8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUI8"/>
    <dbReference type="STRING" id="199890.A0A182PUI8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010626-RA">
        <property type="protein sequence ID" value="AEPI010626-PA"/>
        <property type="gene ID" value="AEPI010626"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010626"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010626-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35397" checksum="5D097E3DD29A2E80" modified="2016-09-07" version="1">LCGITLLSTGFYLFTDSPRILLSRLLISASDQQRTPLSELEQPLFYYVAFALTTAGLYFLIILSLLVAEFGICLMITAWPQCLGLNLNETAMVKALQANYGVPGHEQFTAAMDLAQTIFECCAINTSINYDTSLWKLQSLGKKELTVPLTCCKLVNRFEFTAYLDPAPINVTLCQALQSQDYEKSRHLDGCLHKIELWYREQYFLFLCAGLIVAVVEFCVLLSIILSCTKLPRKNHAAQMLRANPLSHIPIPALPANRRVRDNIYEHELPTPIPVPTIRETYIQPKEYAKQRPDMAFNNNSHYYQISKSYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUU1</accession>
    <name>A0A182PUU1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUU1"/>
    <dbReference type="STRING" id="199890.A0A182PUU1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010728-RA">
        <property type="protein sequence ID" value="AEPI010728-PA"/>
        <property type="gene ID" value="AEPI010728"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010728"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010728-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="660" mass="73667" checksum="1151ABADABE48DD8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUV3</accession>
    <name>A0A182PUV3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUV3"/>
    <dbReference type="STRING" id="199890.A0A182PUV3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010740-RA">
        <property type="protein sequence ID" value="AEPI010740-PA"/>
        <property type="gene ID" value="AEPI010740"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010740"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039190">
        <property type="entry name" value="TTC14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="338"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="634"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="728"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="790"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1257"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="914"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="958"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="972"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1016"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1052"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1139"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1153"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1204"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1228"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1259"/>
            <end position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010740-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1278" mass="141903" checksum="CCCE0DBBBB6DF32B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUW0</accession>
    <name>A0A182PUW0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-terminal Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUW0"/>
    <dbReference type="STRING" id="199890.A0A182PUW0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010747-RA">
        <property type="protein sequence ID" value="AEPI010747-PA"/>
        <property type="gene ID" value="AEPI010747"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010747"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF349">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="49"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="190"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010747-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36880" checksum="28B081360D110FFC" modified="2016-09-07" version="1">SIHRLHNGLLALFLLQKKTRTDKQLPRESPLEQQQHSQGSLGTGGVMYGNGTIVSGPLESLIDLLMPGNVEEFDQDYVFSFLLSARFFIRSYELLGKLLESIPEPEPLERIVPLLGVWTRMFPYDFRDERMMNHVKHIVARCADTKLANVVPQLLCALLARLTELENHEEELRSYQSTVDNKTESISWPTATQLAQLLCRIERKLAKHVGPEEFVQCSPNLLKDPNREDFTPKPTSAGPSGAGSGSGAGQATSLDGKKTCNLESYLEWSARLRLLVANEILKCRNIQDRNKQFELWSGAAQYCLLVGNYNSATAILESFDLPPVARLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUY0</accession>
    <name>A0A182PUY0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUY0"/>
    <dbReference type="STRING" id="199890.A0A182PUY0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010767-RA">
        <property type="protein sequence ID" value="AEPI010767-PA"/>
        <property type="gene ID" value="AEPI010767"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010767"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF748">
        <property type="entry name" value="FI23927P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010767-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="783" mass="86046" checksum="6A932D3A6645D84D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV04</accession>
    <name>A0A182PV04_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PV04"/>
    <dbReference type="STRING" id="199890.A0A182PV04"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010791-RA">
        <property type="protein sequence ID" value="AEPI010791-PA"/>
        <property type="gene ID" value="AEPI010791"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010791"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131946" evidence="2">
        <location>
            <begin position="32"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010791-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="199" mass="21279" checksum="A429635DC7135DD9" modified="2016-09-07" version="1">MLAGSQAKPPVCVAFALVLLGATLHLAGAEATEYEPAGRTVSKRGPTVGLFAFPRVGRSDPELNVDWEASPALLPMETGDDYGITVGSEPCNGLAYPWISFHSPSLPEDYPMKEMKRQGLVPFPRVGRSGKSELAMAAARYWQAARNLQQQQQSLVKRASGSGTTGAMWFGPRLGKRGRFGAASAGSSSEQQQLKAEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV57</accession>
    <name>A0A182PV57_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA dimethylallyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PV57"/>
    <dbReference type="STRING" id="199890.A0A182PV57"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010844-RA">
        <property type="protein sequence ID" value="AEPI010844-PA"/>
        <property type="gene ID" value="AEPI010844"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010844"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01745">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010844-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21116" checksum="4BE525658BBB4670" modified="2016-09-07" version="1">MSSDTPLVVILGSTGTGKTKLSLELAARYGGEVISADSMQVYTGLDIVTAKATKEEQQQAVHHLLDVIDSLLAANRMPIIVGGTNYYIESILWKVLLNEGVKKERVRSHLATYQRDTIEPNKKQLKADGGAPAASSKSELERLLEELPRMESSDALERFDSDLLHRVLQRVDPESADRLHPNNKRKIIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV71</accession>
    <name>A0A182PV71_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Partner of Y14 and mago</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PV71"/>
    <dbReference type="STRING" id="199890.A0A182PV71"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010858-RA">
        <property type="protein sequence ID" value="AEPI010858-PA"/>
        <property type="gene ID" value="AEPI010858"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010858"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010858-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="264" mass="28994" checksum="5E393CAC8231E3E3" modified="2016-09-07" version="1">MTTYSTDSQGKFIPATQRPDGTWRKPRRVRDGYVPQEEVPLYESKGKQFAQKPTLPPGLSPEVVQKAKEKRERERLRAAREEQQRKEQQNKKSVLPPGMLAVDGVNSEKKPASGKNANAASAPRNKKTPELPDILLEQRSASKSKQTTKPSSQQKPTAVGTSAVASAPAATTAISSRSDSNVDDLASSLSSGAQISGADAQQLEVAKKLRKLRKKIREIEAIETKLRATDGPKLDKDQLEKVKRKPDILQEIEELEVQYSAGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVC8</accession>
    <name>A0A182PVC8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVC8"/>
    <dbReference type="STRING" id="199890.A0A182PVC8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010915-RA">
        <property type="protein sequence ID" value="AEPI010915-PA"/>
        <property type="gene ID" value="AEPI010915"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010915"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045835">
        <property type="term" value="P:negative regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22086">
        <property type="entry name" value="F-box_EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047147">
        <property type="entry name" value="FBX5_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493">
        <property type="entry name" value="F-BOX ONLY PROTEIN 5 AND 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493:SF9">
        <property type="entry name" value="GH14043P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="527"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010915-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1011" mass="110270" checksum="657BFBF0D0A7CC22" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVI7</accession>
    <name>A0A182PVI7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVI7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010974-RA">
        <property type="protein sequence ID" value="AEPI010974-PA"/>
        <property type="gene ID" value="AEPI010974"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010974"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010974-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="171" mass="19919" checksum="08A6E8CC9B10D981" modified="2016-09-07" version="1">MASKWNYRGLTAGPLVLSVLYCCATFQWPLVMAEPFYYPPAYYYSTKSWNRPIAGSYGYYQQPSTAAESQNVAVYSAVPNYYGADYEDYQSTLSREKALDDPYLRTNFNNYARFFYYPTARIGDWRDINNGAKYYNSKRRQDSVLPAESKPETTTKQRPRKKKLFVPNVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVI8</accession>
    <name>A0A182PVI8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVI8"/>
    <dbReference type="STRING" id="199890.A0A182PVI8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010975-RA">
        <property type="protein sequence ID" value="AEPI010975-PA"/>
        <property type="gene ID" value="AEPI010975"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010975"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000059">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010975-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="249" mass="27938" checksum="3F47149CD329A47A" modified="2016-09-07" version="1">MSSRYDRAITVFSPDGHLLQVEYAQEAVRKGSTAIGVRGKDVVVLGVEKKSVAKLQEERTVRKICLLDHHVVMAFAGLTADARVLINRAQVQCQSHKLSEEDPVTLEYITRYIAELKQKHTQSNGRRPFGISCLIGGFDYDGVPHLYKTEPSGVYCEWKANATGRSAKTVREFLEEHYSPATVSTEEGTITLAIRALLEVVQSGQKSLEVAVMRRDEPMKMLDAQTIEEYVKKIELAKEEEAEKKKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVN9</accession>
    <name>A0A182PVN9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVN9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011026-RA">
        <property type="protein sequence ID" value="AEPI011026-PA"/>
        <property type="gene ID" value="AEPI011026"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011026"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011026-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="131" mass="15050" checksum="A1C5AB91178F8B0C" modified="2016-09-07" version="1">DDKENESETIGQDLNVLSNISNLGVETSFEEQNCTNCNEKDVEITKLEQKITQEQQRSKELLNANLHYDTAVQEIKQLKKQNIKLTKDLQHYKINSVDSSDVVPRMKIMLKSTLSSNQIDLVIKKETSHMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW66</accession>
    <name>A0A182PW66_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PW66"/>
    <dbReference type="STRING" id="199890.A0A182PW66"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011203-RA">
        <property type="protein sequence ID" value="AEPI011203-PA"/>
        <property type="gene ID" value="AEPI011203"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011203"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011203-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="70" mass="8009" checksum="102B5063224A2A35" modified="2016-09-07" version="1">MLRNCGCFQRARRSSSFEDSSSCRSSEIERGGEMTPHSGSLLKLFTSKGWCRQWRKSGRGMSMTKIERSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW80</accession>
    <name>A0A182PW80_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1741 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PW80"/>
    <dbReference type="STRING" id="199890.A0A182PW80"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011217-RA">
        <property type="protein sequence ID" value="AEPI011217-PA"/>
        <property type="gene ID" value="AEPI011217"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011217"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011217-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="664" mass="76102" checksum="9C1E2CCCFE3F25A7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWD3</accession>
    <name>A0A182PWD3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWD3"/>
    <dbReference type="STRING" id="199890.A0A182PWD3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011270-RA">
        <property type="protein sequence ID" value="AEPI011270-PA"/>
        <property type="gene ID" value="AEPI011270"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011270"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF8">
        <property type="entry name" value="FORKED, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011270-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30797" checksum="2208DC3E0FEED0FB" modified="2016-09-07" version="1">MPLTIDDIALAGLDPPKPPPPPPAPPKTDLIAELKMSKDIAGVKKMKVERAKLEDLQANEVYSEVTRQFTARNYVDQPYHTADKIFQVPERDNAGNIIPDWKRQMLAKKAAEKAKKEFEERLAREAEDRRLSSIPKWKRDLIARKEEAENKLKSTIYTPKVEELQSRSDTWRTRITQRAMSIDNISSFVSESEPGLMPYNKENQFDITTNNISGNIHFSKGNEGFRKSVNGGVANTIGHQISSTQSTKENINNGKLEDGVAHGYHITDTSRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWH7</accession>
    <name>A0A182PWH7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWH7"/>
    <dbReference type="STRING" id="199890.A0A182PWH7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011314-RA">
        <property type="protein sequence ID" value="AEPI011314-PA"/>
        <property type="gene ID" value="AEPI011314"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011314"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002257">
        <property type="entry name" value="CLUMA_CG019509, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF2">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 19, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="65"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011314-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="200" mass="23015" checksum="7B756D4D949A60B3" modified="2016-09-07" version="1">LSLRQVSWFRRKDYQLLTVGLSTYSSDDRFLVEHTRHLGNWALRIKNARKEDEGLYECQISTHPPQSIGMELRIVEAAAEILGLSNMHIDEGSTLRLECKLKRATESPLYVFWYLEDRMVNYDQEDGVSVWNNKLNSSILTVRNVTARHGGNYTCAPANARQASVYVHVLKGKLDYTFSPDVRRFAYGIDLRFLLLLPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWU4</accession>
    <name>A0A182PWU4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic peptide chain release factor subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWU4"/>
    <dbReference type="STRING" id="199890.A0A182PWU4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011431-RA">
        <property type="protein sequence ID" value="AEPI011431-PA"/>
        <property type="gene ID" value="AEPI011431"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011431"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000009">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011431-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="438" mass="49183" checksum="3CB5C500B9A872B5" modified="2016-09-07" version="1">MSFDETSADRNVEIWKIKKLIKSLEMARGNGTSMISLIIPPKDQISRVSKMLADEFGTASNIKSRVNRLSVLGAITSVQHRLKLYTKVPPNGLVIYCGTIVTEEGKEKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLADDNKFGFIVMDGNGALFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVAEVATQLFITNDKPNIAGLILAGSADFKTELSQSDMFDPRLQSKVIKLVDVSYGGENGFNQAIELAAESLQNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLKALELGSVETLICWENLDIQRYVLKNHASATSTTVLHLTPEQEKDKSHFTDKESGVEMELIESQPLLEWLANNYKCFGATLEIITDKSQEGSQFVRGFGGIGGVLRYKVDFQSMQLDELDNDCFDLEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWW8</accession>
    <name>A0A182PWW8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWW8"/>
    <dbReference type="STRING" id="199890.A0A182PWW8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011455-RA">
        <property type="protein sequence ID" value="AEPI011455-PA"/>
        <property type="gene ID" value="AEPI011455"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011455"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011455-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="121" mass="14129" checksum="F29B56F209B37A0F" modified="2016-09-07" version="1">MQEEIEERRLTVASVSADRFMSMVHEMADLSEVMKLQYLLASLKGDALAQFDHVQLSSGNYDTTWKALLDRYDDSKILRREYFKALYRLEPMNEATAKELIRQIEEDTGNMDDMFYTNDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYW5</accession>
    <name>A0A182PYW5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYW5"/>
    <dbReference type="STRING" id="199890.A0A182PYW5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015033-RA">
        <property type="protein sequence ID" value="AEPI015033-PA"/>
        <property type="gene ID" value="AEPI015033"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="AEPI015034-RA">
        <property type="protein sequence ID" value="AEPI015034-PA"/>
        <property type="gene ID" value="AEPI015034"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015033"/>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015034"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015033-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="136" mass="15328" checksum="F5D93D279E6860AA" modified="2016-09-07" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAVAALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYY8</accession>
    <name>A0A182PYY8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYY8"/>
    <dbReference type="STRING" id="199890.A0A182PYY8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015056-RA">
        <property type="protein sequence ID" value="AEPI015056-PA"/>
        <property type="gene ID" value="AEPI015056"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015056"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11057">
        <property type="entry name" value="CYP313-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000035">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015056-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="494" mass="57507" checksum="D3327437D8EA71F4" modified="2016-09-07" version="1">MWWLCVSLVLAVAGLLQWWILQRHRFADHLPVMQPNYPIIGNGHLFLGKSRVELFNVLIRPFRQHSGWFKIWLGPKLVLATSHPDIMSAVLTHTDCLEKPFFYDFVKLEHGIFAGHYHPWKTQRKALNPAFNTRILNSFIPVFVQCSKQMVQQMENSVTDGGRTLSIFPFISKCTLEMVCGTTIGCDVMEQPGKETFIENVDRCFELVAKRMLNMHHYIELLYRWTQDCAEESERRTSCYRFFESVIEKAKARIRSRTDVDENEDFKKPQIFADQLLSVHHNGNPFTDIEITHNIYSMIAAGNDTTALQVTHTCLFLAMFPEIQERVYREVMDVFPDPDQDITLDDLRHLTYMERVIKESLRLAPSGPNIARQTMKDVQIAGLNIPKDSLIVMSIFSMHRRKDVWGPDADKFDPDRFLPERSEGRNVNSFMPFSAGSRNCIGARYAMLSMKVMLSSILRRLRLKSDMKMNELQFRFDLTLKLESECMLYLEKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PPR6</accession>
    <name>A0A240PPR6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D7 short form salivary protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PPR6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015309-RA">
        <property type="protein sequence ID" value="AEPI015309-PA"/>
        <property type="gene ID" value="AEPI015309"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015309"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000008">
        <property type="entry name" value="D7-related 4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013348887" description="D7 short form salivary protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015309-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19153" checksum="991519D077DC1CB7" modified="2017-10-25" version="1">MIAGKASLISLIALCFAAIVQSETVKDCEDKLPPSLKSRLCEIRQYKIIEGPEMDKHIDCVMKALGLVYSDGRGDYHKLYEPLNWIELDKRHDVNLETCIGKSVRVPTSERAHVYYKCLLNTTTGRTFKKVFDLEELKQAGLVPKHQRSYLAEHVQMMKDIDAKLCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZE3</accession>
    <name>A0A182NZE3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZE3"/>
    <dbReference type="STRING" id="199890.A0A182NZE3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000023-RA">
        <property type="protein sequence ID" value="AEPI000023-PA"/>
        <property type="gene ID" value="AEPI000023"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000023"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22955:SF77">
        <property type="entry name" value="ASPARTIC PUTATIVE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22955">
        <property type="entry name" value="RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000023-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="102" mass="11235" checksum="C06D476450009E67" modified="2016-09-07" version="1">MIGSGGANTVEETILLRFELCKWTSNNLCILSGSGTLTKLVLGISWRPESDELIFDSSVCDNADTSTKQSILSRIAKMYDPLGLVAPVIVRAKILMQELWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZG9</accession>
    <name>A0A182NZG9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZG9"/>
    <dbReference type="STRING" id="199890.A0A182NZG9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000049-RA">
        <property type="protein sequence ID" value="AEPI000049-PA"/>
        <property type="gene ID" value="AEPI000049"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000049"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000072">
        <property type="entry name" value="CLIP-domain serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="197"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000049-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="480" mass="53523" checksum="A0A7C7B790326AE6" modified="2016-09-07" version="1">MLPIHCGRAGPRTPSKDQTASVPTVPRFLAARVKQPRHSSSTSSSSQLFTTFRASRHLGVRTDRWLDAVTDIIHNVLGLPDTCVYQNQIRACRLSFSCWLEGGRHVSGCGENRWLMSCCVYDNEQSSAVIAPKVAYAGPMVPVPIIQPIVPVNRPNMIAPAQSFTKKKSFFHRRSDQLMQNECGIPQTSQNTLQKRIIGGRTANFAEYPWQAHIRIAEYQCGGVLVSRRFVATAAHCIQQARLKDILIYLGELDTQNSGKIVEPLPAEKHRVEMKIVHPKFIFRMTQPDRYDLALLKLTRPAGYKSHILPICLPMRPLELVGRKGIIAGWGKTNANMGQTGTNILRTAAVPIISTKECLRWHSSKNINVELFNEMFCAGHSDGHQDACLGDSGGPLIINDRGRYTLIGITSAGFGCGVDHQPGIYHNVQKTIKWIQSRIGGFTGANARFNEVLDRENLRTLISRQLPKQGRFFEEFDGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZU6</accession>
    <name>A0A182NZU6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZU6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000177-RA">
        <property type="protein sequence ID" value="AEPI000177-PA"/>
        <property type="gene ID" value="AEPI000177"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000177"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130600" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000177-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10000" checksum="3A0FBDCACC9B2A5B" modified="2016-09-07" version="1">MKFLTVTLLICLLSIVCSGEDTTAADKEETTTTSKEGDGGAQETPDVKTDDHPKDKPDMSPIDFVQEVIRNAMKRISSGFQDTVKIMPFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P023</accession>
    <name>A0A182P023_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phospholipase A2</fullName>
            <ecNumber evidence="2">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Phosphatidylcholine 2-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182P023"/>
    <dbReference type="STRING" id="199890.A0A182P023"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000255-RA">
        <property type="protein sequence ID" value="AEPI000255-PA"/>
        <property type="gene ID" value="AEPI000255"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000255"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase A2-like central" evidence="6">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000255-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="109" mass="12621" checksum="B22F6B4FB9B98D13" modified="2016-09-07" version="1">MRAIAKPSQESVDDGDLVENFDRPSFGVVEGSYSLFQTPLVDRAPRFRTCLKLADSKDANLVGKLFFNVMQMKCFVFKPETVCTKKSWWGTCERKGRRKRAVLRHNRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0D9</accession>
    <name>A0A182P0D9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. NFIL3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0D9"/>
    <dbReference type="STRING" id="199890.A0A182P0D9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000371-RA">
        <property type="protein sequence ID" value="AEPI000371-PA"/>
        <property type="gene ID" value="AEPI000371"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000371"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14694">
        <property type="entry name" value="bZIP_NFIL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000025">
        <property type="entry name" value="nuclear factor interleukin-3-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047229">
        <property type="entry name" value="NFIL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047106">
        <property type="entry name" value="NFIL3-like_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284:SF0">
        <property type="entry name" value="GH23983P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284">
        <property type="entry name" value="NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="118"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="701"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="785"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="74"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="375"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="499"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000371-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="829" mass="89194" checksum="D0D4ACE0C2469D94" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0K4</accession>
    <name>A0A182P0K4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0K4"/>
    <dbReference type="STRING" id="199890.A0A182P0K4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000436-RA">
        <property type="protein sequence ID" value="AEPI000436-PA"/>
        <property type="gene ID" value="AEPI000436"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000436"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000035">
        <property type="entry name" value="DnaJ homolog subfamily C member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000436-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="284" mass="33072" checksum="0D2855228B4BF6BB" modified="2016-09-07" version="1">MSTLEVCEKYYGTKNIYELFGVNKSASDQEIKKAYYRLSLQTHPDRVPEGDKKEATEKFKVLSKLYNILSNKDSRAIYDERGIVDDDDNASTNWLARWQQFFKPLTTEDIDNYQKSYVGSETERNDIKRAYLRGKGCKNMMMSYVPFMKCEDEPRIAEIVQEMIDSNEVPEYKIFTNEPEAKRKKRHRKYALEAMEASQMKQKMQDTASLEQQIALKREHAFTSLIESLEAKYGNNEDDTDDLYEIDEEESPRKRKPTSSRKPMKSAEKKPPVAAKKKKGSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0R9</accession>
    <name>A0A182P0R9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SH3 domain-binding protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BP5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0R9"/>
    <dbReference type="STRING" id="199890.A0A182P0R9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000501-RA">
        <property type="protein sequence ID" value="AEPI000501-PA"/>
        <property type="gene ID" value="AEPI000501"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000501"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007940">
        <property type="entry name" value="SH3BP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423:SF1">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05276">
        <property type="entry name" value="SH3BP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="123"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000501-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54180" checksum="D5A1B5C72CC07E3B" modified="2016-09-07" version="1">MESWCCLLVEANSTFRILMNESTRRLKLSSKKLGSCIEKARPYYEALEKAKVAQLECQAATLKYQRANEIHAAAKETVALAEQRFMSNSHEWQFDNAWQEMLNHATIKVMDAEKQKAESGAEHQKKAKVFEEAEKKVQQLEERYRRSIQKSRPYFDEKQLCQEQLEAQKGRIQQLEQQIQAAKSAYSTALRNLEKISEEIHEQRGDLSQAAPSGPREPGVGAELANILPTATATTTNTIHKVPGKDRFPYSSTMPDISSELDKCEIRSVGSASVATSSAVSEKDPSEEDDYSTMTLHDEDDLPSSTAVHDDDLHLELLRQKVRTLAVRPVEGGDGQQQEQDVWEHELNATVDKLDHLMMLRECSRSSTLSGSGVTPAGENGAATFCSLPTTPKHHPTHHQHREHHLSPADSPAHEQHSIKMFKKLDPLPLANVSMYALPTYLNAASCGGSNNGGISLLTPISATSPGDVCEPGVGGEGALASKLKRKMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0U7</accession>
    <name>A0A182P0U7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0U7"/>
    <dbReference type="STRING" id="199890.A0A182P0U7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000529-RA">
        <property type="protein sequence ID" value="AEPI000529-PA"/>
        <property type="gene ID" value="AEPI000529"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000529"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FG-GAP"/>
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        <property type="entry name" value="Int_alpha_beta-p"/>
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    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
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    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
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        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
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        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1026"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="238"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="298"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="360"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="15">
        <location>
            <begin position="408"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="16">
        <location>
            <begin position="600"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="17">
        <location>
            <begin position="758"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1063"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000529-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1105" mass="119652" checksum="77FBE644C05D8A30" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P191</accession>
    <name>A0A182P191_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P191"/>
    <dbReference type="STRING" id="199890.A0A182P191"/>
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        <property type="protein sequence ID" value="AEPI000673-PA"/>
        <property type="gene ID" value="AEPI000673"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000673"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="108"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000673-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="356" mass="39119" checksum="FC01091A194BB49F" modified="2025-10-08" version="2">MDGSLVLTNLTGRDSGRYTCSAAIPTLTTVAVLEGSDADPSTAGGNDTTSTRPAYESADGSTGYDNATAEPYEGGEEEEQEEEDGGGGGAAEEHFVELLKVNVKVRTPPLAVSNFYVRASTIIAVLVWEVMPNRTGGYAIRDFTAEMRKMQDSSENVTELPWETIDPRHISPNARQLEIYHLIPNTTYEFRIWGNNQLGAGEIVTILATTQPRMEEKDLVRRIMIDAKNFDTRVWIAAVGIVMGTLVILSLGTCIVLYKECREPAANDKDEELDSLELVPNIILNPGFCDSDDQGQNPLAPPIPRTLPYNRYRTPDGRGPAGGDDDGDDDDDEEEEPMTFSRRMSIFFTGNTIKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1D9</accession>
    <name>A0A182P1D9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Trafficking protein particle complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Golgi apparatus</location>
            <location evidence="2 10">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1D9"/>
    <dbReference type="STRING" id="199890.A0A182P1D9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000721-RA">
        <property type="protein sequence ID" value="AEPI000721-PA"/>
        <property type="gene ID" value="AEPI000721"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000721"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000005">
        <property type="entry name" value="Trafficking protein particle complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000721-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="192" mass="21890" checksum="7443799D805E5D15" modified="2016-09-07" version="1">MEKINLNLSTRPKASILDKPLSRGKGEVSLSSYALLFSELVQYSQSRVSTIPDLQTRLHDLGKDVGCRIIDLYFVRERNSKRETKLINMLLFIKTTLWKTLFGKEADKLEHATDDECTYYIIEKEPLVNKFISVPKDKGSLNCAVFVAGIVQAVLSNCGFTCQVSAHWHKGTTYMVKFEDHVISRDKQLEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1J9</accession>
    <name>A0A182P1J9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination factor 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1J9"/>
    <dbReference type="STRING" id="199890.A0A182P1J9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000781-RA">
        <property type="protein sequence ID" value="AEPI000781-PA"/>
        <property type="gene ID" value="AEPI000781"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000781"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.70.10:FF:000002">
        <property type="entry name" value="transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF112">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000781-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="356" mass="41546" checksum="2A267F4C856C59D2" modified="2016-09-07" version="1">MRSILKGIIKIGIPARAGPSLQRQLCTKVAAVTVNPQHSALQRYEDDLQNEFQQILREERQSVLEPVEDPTSLEVFPNTKPAFNFAAYVNKSPTLQQLVSLGVELHKLEKRKGIAQFVLGLDFDRDMKNHIRFLADIGVPAESFGEFLTKNPLIFKEDIGDLETRVNYLQSKRFLSEEITRIVSKNPFWLMLSTKRIDRRLGYFQKTFVLEGAEVRALATKQPRLITYNLEHVRKNTFTVQEEMGFEKEEVKQLLLSKPRIWMIKTEALQYRFEYLHRRMKLTHAQLLQTPDLLLTRDVRIKQRHGFLKFLGKVQYDPKKELYIPLKSLAEGTDEEFVTEVAKSNMECYNRFLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1Q5</accession>
    <name>A0A182P1Q5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1Q5"/>
    <dbReference type="STRING" id="199890.A0A182P1Q5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000837-RA">
        <property type="protein sequence ID" value="AEPI000837-PA"/>
        <property type="gene ID" value="AEPI000837"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000837"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="741"/>
        </location>
    </feature>
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        <location>
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            <end position="839"/>
        </location>
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        <location>
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            <end position="918"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="944"/>
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        <location>
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            <end position="977"/>
        </location>
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        <location>
            <begin position="48"/>
            <end position="523"/>
        </location>
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    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="549"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000837-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="981" mass="106630" checksum="45776AE3A4451ED1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1Y4</accession>
    <name>A0A182P1Y4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1Y4"/>
    <dbReference type="STRING" id="199890.A0A182P1Y4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000918-RA">
        <property type="protein sequence ID" value="AEPI000918-PA"/>
        <property type="gene ID" value="AEPI000918"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000918"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000899">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
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    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00360">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000918-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="143" mass="16176" checksum="6DB586CB3690B363" modified="2016-09-07" version="1">MARYREWDLQCKVYVGNLGSSASKHEIESAFGKYGPLRNVWVARNPPGFAFVEFEDKRDAEDAVRSLDGTRCCGTRIRVEMSSGRSRRDERTRRPRRSYRANSSMILLLHDSVFRHRTSSCPNFASSATSVKSTTATTTTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P200</accession>
    <name>A0A182P200_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P200"/>
    <dbReference type="STRING" id="199890.A0A182P200"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000934-RA">
        <property type="protein sequence ID" value="AEPI000934-PA"/>
        <property type="gene ID" value="AEPI000934"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000934"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="56"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000934-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="101" mass="11486" checksum="8BA3A1796EDF342A" modified="2016-09-07" version="1">MLLHLTITVKLLYFSHRPCDRNLRDCELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGEQGRYWYAVLGGQLEVRYHAADTKDGKVGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P204</accession>
    <name>A0A182P204_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P204"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000938-RA">
        <property type="protein sequence ID" value="AEPI000938-PA"/>
        <property type="gene ID" value="AEPI000938"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000938"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009832">
        <property type="entry name" value="DUF1397"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20997">
        <property type="entry name" value="EG:BACR42I17.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20997:SF2">
        <property type="entry name" value="EG:BACR42I17.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07165">
        <property type="entry name" value="DUF1397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130729" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000938-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27200" checksum="D4FE8E6C93129269" modified="2016-09-07" version="1">MRVERAVIFILATFVTAAHGEEPSQVDAPDALDFSYARLWRYAQQECAIKGITPTEFTHSWLGVRRCLKNTLDVVQLNEDSMRLNVDNQEEILSRHCPKLFQGVKCFNPFMDMVKGCVNEESYEIFQALRSWFHNILEYLCENNGANIEYDKQKHDTCTREINKHIITCAAENLIATPEVNRKTLSEENCNALASAKDCLLAKLKDCGVFANGARLFYENFIQITSCKNYIPKTERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2P1</accession>
    <name>A0A182P2P1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2P1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001175-RA">
        <property type="protein sequence ID" value="AEPI001175-PA"/>
        <property type="gene ID" value="AEPI001175"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001175"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF56">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="134"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001175-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="425" mass="47898" checksum="092D94D8B49DFA9E" modified="2016-09-07" version="1">MPKTAETKFVNSLFLTNLIQTQYGESEVKIKAYDVEPASADINDPYARSSMNRILIKYTSKENPTDAVITFVAKIKPTEGPLVEQFKKADVFEKEILMYKSVLPSMVTMISKLGSVIELAPQLIYSSETPSDLVVLEDLTARGYSVENQTLGLSYDQSKMAVEKLAFFHAASAMMLSENGQAFPKFAKGTFHTEHKDKLSYFPDTIRLLAEMASELEIDQPLADKLRKLPEKTLQKAVEAYESDLKGFKVLNHGDFWTNNILFKYQGNELVDAIFVDFQNCVVGSPIIDLVYFLAASPAHEVLEKHRDELVYVYHETLVLLLQKLGYMKPVPSLLELQVVLLKHGSLQVIYALTVSPFMRTKDAHNTPPMQPTLHSVNQSTNVKQILRAHSPNIVAQLKAYERVGLLDWGANESKIKGLMSRFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P323</accession>
    <name>A0A182P323_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Peptidyl-prolyl cis-trans isomerase E</fullName>
            <shortName evidence="10">PPIase E</shortName>
            <ecNumber evidence="4 10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4 10"/>
    <dbReference type="AlphaFoldDB" id="A0A182P323"/>
    <dbReference type="STRING" id="199890.A0A182P323"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001311-RA">
        <property type="protein sequence ID" value="AEPI001311-PA"/>
        <property type="gene ID" value="AEPI001311"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001311"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000321">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016304">
        <property type="entry name" value="PPIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001475">
        <property type="entry name" value="PPI_cyclophilin_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="13">
        <location>
            <begin position="148"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001311-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="307" mass="33682" checksum="6F364A003EA4BB16" modified="2016-09-07" version="1">MANDKRTVYVGGLSEEVTDKLITDAFIPFGDLVDIQMPIDYESQKHRGFAFIEFENAEDAAAAVDNMNDSELCGRTIRVNTAKPQRIKEGSNRPVWADDNWLQKHAGATLKNDGDTNGDQQQMDTGGDEVQPKEPKAPEEKKRNPQVFFDIRIGNSDVGRIIMVLRADVVPKTAENFRALCTGEQGFGYKGSTFHRIIPEFMCQGGDFTAHNGSGGKSIYGKKFADENFTLKHTGFGVLSMANSGPNTNGSQFFICTEKTDWLDGKHVVFGNVISGADVVRKMERCGSKGGRVQQKVTIVACGEVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3K7</accession>
    <name>A0A182P3K7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3K7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001492-RA">
        <property type="protein sequence ID" value="AEPI001492-PA"/>
        <property type="gene ID" value="AEPI001492"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001492"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130791" description="EB domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001492-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23465" checksum="71C739365DC2E3BD" modified="2016-09-07" version="1">MYKDRRLYLLVLYVFAIQLPMSIGGNPRDSAQVSARNVANNGTSNSVSSTRNNSSTNTVACREDVLDQCPPNASCDKSQCVCLFGYKLNAAYHGKNASTGPSTASVPSTNIAYTAYCLPDELGAKATSLHGGTSSNSNKAPGEVASAAGDGGNAGQLPLREPVGAHHILGGVLIPLAFVVILIGSAILAKRIDLWSRLRQRFLAHRNRHRRRPAYEDVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3Q1</accession>
    <name>A0A182P3Q1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3Q1"/>
    <dbReference type="STRING" id="199890.A0A182P3Q1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001536-RA">
        <property type="protein sequence ID" value="AEPI001536-PA"/>
        <property type="gene ID" value="AEPI001536"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001536"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="1160"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1249"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001536-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1273" mass="142134" checksum="B32D30C5001F1736" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4A9</accession>
    <name>A0A182P4A9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4A9"/>
    <dbReference type="STRING" id="199890.A0A182P4A9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001745-RA">
        <property type="protein sequence ID" value="AEPI001745-PA"/>
        <property type="gene ID" value="AEPI001745"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001745"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001745-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="337" mass="37975" checksum="CB96EFC1206C5378" modified="2016-09-07" version="1">MFRGKIRTNTCRIVVLTSLVWLLIDVILIVKYAECPSGGDGSSWLCRRSGYDVESRSVLSVVSLTSSMSVRGLTTLLLLFGSCIACLHAKDTPDFAAKSEDMVPLTQTLQSHVEKFKKLRDDLKALQETKEDQNPLVFFRETMRIMDGLQSLGKEWKDIERMQNRGKRSRDRVEFESVLEQMDPLCGQRNQRSAALEIELRCQYSDLGGNPYYLIGPVKEEQLNLVPFRVTVYRDLLTEGEVRRANETRQIEVNVRQRLNTLVPDLVNVAVRKVGENGYNGSRVKQHGVSMMLYLETRNNGGMTMFPGGTFIVAPTSGSLLVSKERPSICPSNSAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4G6</accession>
    <name>A0A182P4G6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A182P4G6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001802-RA">
        <property type="protein sequence ID" value="AEPI001802-PA"/>
        <property type="gene ID" value="AEPI001802"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001802"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001802-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="467" mass="54629" checksum="05DCB6DFD4ECBDC9" modified="2016-09-07" version="1">MRRKCKHTQNYAKLQQKYIHQTLPLYQRSVSLTLGNESRLHEEDTGQHDHWSPIGDPEKRFKIYSAYFDPRLEVVESYLVPDGFLPFGSIRIFAILPYKIRKEDVFCNFRSDNVYAAIHRADEVEAVHEHWNMEFAASYVICKLAGNITKREARLPDEVALSYIAEPSMQEATSFVRIKYPKTDRLFRSAPSRSLAICVGPLHHDFSYALRVVEFFEYYIMNQAERFYVYNKSATPEVDTVLRHYQATGLVQVLDWHFDGYKFESELRYEGIFVALNDCLYRATVAGGFRYTAIVDFDELLFPAGDNETLLEYLQTKDRYDVHSFNFQGVFFYDIYSPDFSQVPSGSNNKYLYTQVRNVRTKNPLLHHNRSKYILKGRNVLEAGNHFVWKAVRDTHEYAVPENEGLLMHYRDGSLGYDFENVVLDNRIRQRFGEVLWRRVNKKCALIFPESGVCPLGVNYNKTSSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4P0</accession>
    <name>A0A182P4P0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4P0"/>
    <dbReference type="STRING" id="199890.A0A182P4P0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001876-RA">
        <property type="protein sequence ID" value="AEPI001876-PA"/>
        <property type="gene ID" value="AEPI001876"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001876"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03535">
        <property type="entry name" value="Paxillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001876-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="211" mass="22839" checksum="2F72A4BDD5A460A1" modified="2016-09-07" version="1">MEPLTYESVQENCQDFLGMGTLINRNHALLADLQNTVPGHNQQHGGGGGGSSVPGYGSLNGVRNKQQTSPVPQTYQNTTTKTVTESRATNGYNGSLPRSTTPHNSLPRSSTPQKLQTSASGNLSELDSLLQDLSSARYGNVAEKRKNQNANQPGRQVTITVRETTTEKLTGTPSAQYQNQLYQQQLAQNESHTSSATKELDDLMASLSDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P561</accession>
    <name>A0A182P561_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P561"/>
    <dbReference type="STRING" id="199890.A0A182P561"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002049-RA">
        <property type="protein sequence ID" value="AEPI002049-PA"/>
        <property type="gene ID" value="AEPI002049"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002049"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000018">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="193"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002049-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="389" mass="45423" checksum="9993EA02B2BA6CE3" modified="2016-09-07" version="1">MPVENLEEQGLEKNPNLELSQCKFLLSLPEFANDKKLSEKLLVAIKAENMAPWYEQVCADLGWTVDQKQLAEMKETNRKKLEQLDAAIEDAEKNLGEMEVREANLRKSEYLCRIGDKEGAITAFRKTYEKTVSLGHRLDIVFHQIRIGLFYLDHDQITRNIDKAKYLIEEGGDWDRRNRLKVYQGAYCIAIRDFKAAAHFFLDTVSTFTSYELMEYSTFVRYTVYVAMISLPRNELRDKVIKGAEIQEVLHQTPDVKEYLFSLYNCQYADFFKHLAAVELVLRNDILFHPHYRYYVREMRILAYTQLLESYRSLTLQYMADAFGVSVDYIDAELSRFISAGRLHCKVDRVGGIVETNRPDSKNWQYQATIKQGDILLNRVQKLSRVINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5C6</accession>
    <name>A0A182P5C6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5C6"/>
    <dbReference type="STRING" id="199890.A0A182P5C6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002116-RA">
        <property type="protein sequence ID" value="AEPI002116-PA"/>
        <property type="gene ID" value="AEPI002116"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002116"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF247">
        <property type="entry name" value="GH16156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="5">
        <location>
            <begin position="506"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002116-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="700" mass="78684" checksum="3A08ED7546E2EC5A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P715</accession>
    <name>A0A182P715_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L45, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL45 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P715"/>
    <dbReference type="STRING" id="199890.A0A182P715"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002715-RA">
        <property type="protein sequence ID" value="AEPI002715-PA"/>
        <property type="gene ID" value="AEPI002715"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002715"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000003">
        <property type="entry name" value="39S ribosomal protein L45, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="10">
        <location>
            <begin position="140"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002715-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="336" mass="38847" checksum="034B7DB75B926EE9" modified="2016-09-07" version="1">MASFVAASRAAIKFLQLPSTGFLAPCLQNASIINQQQVRHRRTKHWDPKWKRLRKAKFIKIDIPNLNERPEDLTQEQMKTRMKERGILPPRPWLERPFYISCTGGVFEPYVPPEGDGRMSAISREGAKQKIEQLEKKTKSMMAIRKIRNYDEDFEPPEFATLAQDIYIDAHKTLCEKNKYKLREIVTERAYPELMHNVADKTIRWQFLKSLEPPRVVHARCTDVITKENIFAQVTVRFHSQQTLAIYDRFGRLMHGSETVPKDCLEYVVFEKHLANEYGVWRLHEKIIPDWMPPKAPAFITYRVDDEPPVAAADAETKEVVPAEGEAAKSESVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7S9</accession>
    <name>A0A182P7S9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aralkylamine N-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.87</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dopamine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecanoyl)-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31883"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:51381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dopamine + acetyl-CoA = N-acetyldopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51388"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:125678"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:51389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dopamine + hexadecanoyl-CoA = N-hexadecanoyl-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:134058"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:51377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>serotonin + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:51397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>serotonin + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:134064"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:51393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25217"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17697"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:25218"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>serotonin + hexadecanoyl-CoA = N-hexadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51384"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:134059"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:51385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>serotonin + octadecanoyl-CoA = N-octadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:134065"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:51401"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182P7S9"/>
    <dbReference type="STRING" id="199890.A0A182P7S9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002982-RA">
        <property type="protein sequence ID" value="AEPI002982-PA"/>
        <property type="gene ID" value="AEPI002982"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002982"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000046">
        <property type="entry name" value="Dopamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002982-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="268" mass="30329" checksum="ADFED9B687A7BA5D" modified="2016-09-07" version="1">MKVEIQNHVEHLPALNGLTLSNLLTRSNCMATPKAPTICDGKVDDADAKLNEIDRELSISVITEADTEAVLDLLKRFFFKDEPLNTYVQLGECKELEKYCTKSLGEHSSYKATNSRGEIVGVILNGTIMKPQPSDEPPAKLADNCAHPKFKKIMALMDYVDEQFDIFELYPDIDRFLDCKIISVDTNYRGMGIAGMLTDRTLDYATRNGIKLIHVLCSSHFSARVMEKMDFSEVYRLPYADYLVNGEQVFDPEKPHVAVRILTKRLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA00</accession>
    <name>A0A182PA00_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PA00"/>
    <dbReference type="STRING" id="199890.A0A182PA00"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003754-RA">
        <property type="protein sequence ID" value="AEPI003754-PA"/>
        <property type="gene ID" value="AEPI003754"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003754"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15880">
        <property type="entry name" value="SNARE_syntaxin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000068">
        <property type="entry name" value="Syntaxin 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000001">
        <property type="entry name" value="Syntaxin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF424">
        <property type="entry name" value="SYNTAXIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="188"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003754-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="321" mass="37315" checksum="E680230FE42CEF8A" modified="2016-09-07" version="1">MPEDVAVPVEGSFMEDFFKEVEEIRMMIDKIQANVEEVKKKHSAILSAPQSDEKTKQELEDLMADIKKTANRVRGKLKGIEQNIEQEEQQSKSNADLRIRKTQHSALSRKFVEVMTEYNRTQTDYRERCKGRIQRQLEITGRATTNEELEEMLEQGNSAVFTQGVNHFSHIMKCMRIIMETQQAKQTLADIEARHADIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYHVEHAMDYVQTATQDTKKALKYQSKARRGEMVDRIEYHVENSRDYVTTGQQDLVQAVKYMAKARKKKIMILICLTVLGLIVASYVSSYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA02</accession>
    <name>A0A182PA02_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetylneuraminate lyase</fullName>
            <ecNumber evidence="5">4.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23296"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17122"/>
            <dbReference type="ChEBI" id="CHEBI:173083"/>
            <dbReference type="EC" id="4.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family. NanA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PA02"/>
    <dbReference type="STRING" id="199890.A0A182PA02"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003756-RA">
        <property type="protein sequence ID" value="AEPI003756-PA"/>
        <property type="gene ID" value="AEPI003756"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003756"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF21">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="12">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003756-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="282" mass="31422" checksum="512F58B08FED1486" modified="2016-09-07" version="1">MKSFNFAGLMAPVFTPYSNNNETININAIEPYVKLLKANHVNGVLVNGTSGEGMLMSTTERMLVAETWQKCCNDHELTVMVQIGGAPFPDVVQLAQHASKIDVDAVLCLPELYFKPKSCEQLVAYLKGVAKYCPSTPFFYYHIPMFTDVNLHMPTFLNCAEKDIPNFRGIKYTSGDLELGSACLKEGRTIFLGADTILCGAIAAGFDSFIMTTINICPETAFEIINHMNRGELKEAREKQRLLNVRIGEILTHGDWVSAMKKVFRERFPSIEVGTTRPPLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA89</accession>
    <name>A0A182PA89_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PA89"/>
    <dbReference type="STRING" id="199890.A0A182PA89"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003843-RA">
        <property type="protein sequence ID" value="AEPI003843-PA"/>
        <property type="gene ID" value="AEPI003843"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003843"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003843-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="117" mass="13001" checksum="D4D6CC2EEFB772AD" modified="2016-09-07" version="1">METCVLIPQEFALAVTGVGARHSPEQTATVWSSVPIPQGRLCYPFQGTVRIDNLAIFSALAEDDRINSIELIELSKCDLIGRKASPHPIAHITTSRNLHLEQDEPARFIRARPSHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAG3</accession>
    <name>A0A182PAG3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PAG3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003917-RA">
        <property type="protein sequence ID" value="AEPI003917-PA"/>
        <property type="gene ID" value="AEPI003917"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003917"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16787">
        <property type="entry name" value="mRING-HC-C3HC5_CGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000447">
        <property type="entry name" value="helicase SKI2W isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="340"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="713"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="945"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1518"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003917-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1647" mass="184347" checksum="E936042473CE9657" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBF7</accession>
    <name>A0A182PBF7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NTR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I35 (TIMP) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBF7"/>
    <dbReference type="STRING" id="199890.A0A182PBF7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004262-RA">
        <property type="protein sequence ID" value="AEPI004262-PA"/>
        <property type="gene ID" value="AEPI004262"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004262"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03577">
        <property type="entry name" value="NTR_TIMP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.370.10">
        <property type="entry name" value="Tissue inhibitor of metalloproteinase-1. Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027465">
        <property type="entry name" value="TIMP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF33">
        <property type="entry name" value="TISSUE INHIBITOR OF METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00206">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0481">Metalloenzyme inhibitor</keyword>
    <keyword evidence="4" id="KW-0483">Metalloprotease inhibitor</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131170" description="NTR domain-containing protein" evidence="10">
        <location>
            <begin position="27"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="11">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="29"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="39"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="144"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004262-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="208" mass="23241" checksum="8657FD34B6288696" modified="2016-09-07" version="1">MKTKRLLPLILTMLGLTMVMLPTAETCSCEMVHPQTAFCNSDYVIVAQVLRKTASKYPHTDAYKIAIKKEYKMTDEARKLLSDGKLYTSSFDASCGIKLEPSKLYAIAADTEHVGLCDYIEPYAELSLVEKRGLAGVYRKGCKCRISFQQGKRQGNCNWLPFSQKGECERSYGSCVPVGVVKPDGVPIKCHWRRSPRFGQCMAKHGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBS8</accession>
    <name>A0A182PBS8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBS8"/>
    <dbReference type="STRING" id="199890.A0A182PBS8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004384-RA">
        <property type="protein sequence ID" value="AEPI004384-PA"/>
        <property type="gene ID" value="AEPI004384"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004384"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="221"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="277"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004384-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="340" mass="38569" checksum="DEE01CC8043B8BD4" modified="2016-09-07" version="1">MSERKVLNKYYPPDFDPSKIPRVKLPKNRQYTVRLMAPFNMRCVTCGEYIYKGKKFNARKEDVENEDYLGIRIYRFYIKCTRCLQEISFKTDPRNTDYEIEAGATRNFMALKLAEEQARREEEEAREEEATNPMKLLENRTQQSRNEIELLESLEELRDLNRRQQDIDYDSMLQQFDRSESIREREERLERQDEEYIKSIKFQNKPGVKRVATEIIVEEVKEETPDEASTSATESSKPSSSSTVTSTAVSTSAPTFATSKARKLDNISIGVKKTTLSNLVVKRKEMPPPKAPPPPPALVNKAVEGPAATAPAKTGTVSSGIGSLGLLGAYSDSDEGSDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC56</accession>
    <name>A0A182PC56_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC56"/>
    <dbReference type="STRING" id="199890.A0A182PC56"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004511-RA">
        <property type="protein sequence ID" value="AEPI004511-PA"/>
        <property type="gene ID" value="AEPI004511"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004511"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000014">
        <property type="entry name" value="Optomotor-blind protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF181">
        <property type="entry name" value="OPTOMOTOR-BLIND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004511-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="70" mass="8311" checksum="F9D484AAFC6627A2" modified="2016-09-07" version="1">MHKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDTGAGKREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC78</accession>
    <name>A0A182PC78_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H3]-lysine(36) N-trimethyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.359</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="3"/>
    <dbReference type="STRING" id="199890.A0A182PC78"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004533-RA">
        <property type="protein sequence ID" value="AEPI004533-PA"/>
        <property type="gene ID" value="AEPI004533"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004533"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000016">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000137">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
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    <sequence length="2619" mass="290220" checksum="40859CB14DEAA3BD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCF9</accession>
    <name>A0A182PCF9_9DIPT</name>
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            <fullName evidence="4">Methyltransferase type 12 domain-containing protein</fullName>
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        <name type="scientific">Anopheles epiroticus</name>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Epiroticus2</strain>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="2">Epiroticus2</strain>
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        <text evidence="1">Belongs to the UPF0585 family.</text>
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    <sequence length="240" mass="27131" checksum="A147C08BC1B67B1A" modified="2016-09-07" version="1">MVRNVAANLKNVFMYLTTNRFGVMWPTAIIRRRQHAIWPHRRPIMRKITNPAGERNKDPILGVLKCVFSKTEPNLRLLEISSGVGLHAAYFAQEFPNITFQPSEFDSTLFDSIDAYRQDVKNVQPPIYIDISKPCTDWQNEANLNHNSCANGFDYMLNINMLHISPIACAHGLFSNASKLLKPGGLLVTYGPYAVDGVLTPDSNVMPEEYVITLIVERYGTTPPEFWFVVKQCTQHAADS</sequence>
</entry>
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        <alternativeName>
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        </alternativeName>
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            <taxon>Diptera</taxon>
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        </lineage>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCI6"/>
    <dbReference type="STRING" id="199890.A0A182PCI6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004641-RA">
        <property type="protein sequence ID" value="AEPI004641-PA"/>
        <property type="gene ID" value="AEPI004641"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004641"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000010">
        <property type="entry name" value="PX domain-containing protein kinase-like protein isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000830">
        <property type="entry name" value="PX domain-containing serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000063">
        <property type="entry name" value="SEH1 like nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="9 22" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="25">
        <location>
            <begin position="335"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="467"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="491"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="804"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="868"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="915"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004641-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="993" mass="110032" checksum="38BD3A1F01CEC31C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCL7</accession>
    <name>A0A182PCL7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spatacsin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PCL7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004672-RA">
        <property type="protein sequence ID" value="AEPI004672-PA"/>
        <property type="gene ID" value="AEPI004672"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004672"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008088">
        <property type="term" value="P:axo-dendritic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028103">
        <property type="entry name" value="Spatacsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028107">
        <property type="entry name" value="Spatacsin_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650:SF0">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14649">
        <property type="entry name" value="Spatacsin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spatacsin C-terminal" evidence="2">
        <location>
            <begin position="1590"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2016"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2017"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="2032"/>
            <end position="2047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004672-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2074" mass="235157" checksum="FD08F22BE113FC74" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD21</accession>
    <name>A0A182PD21_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PD21"/>
    <dbReference type="STRING" id="199890.A0A182PD21"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004826-RA">
        <property type="protein sequence ID" value="AEPI004826-PA"/>
        <property type="gene ID" value="AEPI004826"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004826"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="5">
        <location>
            <begin position="251"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004826-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="427" mass="47856" checksum="2EFFCBB8117D2B19" modified="2016-09-07" version="1">MKTGEKEKTTYQKLEELEEKIKSLEAYTISTQERRKRFVGRFLVTSIVLYVVGSLIFYFVFFPPTWNERIVYSVPLLICPILIFILKRVLAWHYERKLRLNANKLKDLRADKKKILENVMEKETYKVAVEILDKFGDKSHRIQTQAFNASLTPLRAPKPIPVGAGQLTPRMPATNLPQRQISPPSIGVGPATPMTPQIRPAGPMHHTPQTAPGLMMRPPHLQQNPIYGSRNNMAYRRTPFPIINQNEKGVLEKMVDYLVGDGPTNRFAMICTECCMHNGMVLKEEYEYTAFRCAFCNALNPAKKQRPVAPRLPYEQEQLDRLSQKADTSSESEAEEGDDGSSGSSQSGEPRSPGVGEEEPFEPEEQLKQEDRRNLAAATSETECSAEAVEASGKKLTPNDDGAQAEGASDSTEVPSRPETVGSKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD54</accession>
    <name>A0A182PD54_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PD54"/>
    <dbReference type="STRING" id="199890.A0A182PD54"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004859-RA">
        <property type="protein sequence ID" value="AEPI004859-PA"/>
        <property type="gene ID" value="AEPI004859"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004859"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004859-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="105" mass="11956" checksum="6C329D0E31D616B0" modified="2016-09-07" version="1">MTTMRNGTDGTIIHPGVVEKDSGQVALIAITIVSLVIIIVGLIIYVLYRHYTHRNSTTMNFDNPVYRKTTEDQFSLEKNIQSRMYPSTVGEEVRAFARDYTVCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDD7</accession>
    <name>A0A182PDD7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="3">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDD7"/>
    <dbReference type="STRING" id="199890.A0A182PDD7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004942-RA">
        <property type="protein sequence ID" value="AEPI004942-PA"/>
        <property type="gene ID" value="AEPI004942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004942"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000002">
        <property type="entry name" value="Erythrocyte membrane protein band 4.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF69">
        <property type="entry name" value="RE08173P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="4">
        <location>
            <begin position="309"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004942-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="743" mass="82867" checksum="B302DB7C370B2E73" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE08</accession>
    <name>A0A182PE08_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PE08"/>
    <dbReference type="STRING" id="199890.A0A182PE08"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005163-RA">
        <property type="protein sequence ID" value="AEPI005163-PA"/>
        <property type="gene ID" value="AEPI005163"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005163"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000011">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="30"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="229"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005163-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="527" mass="58561" checksum="D3B369190C3961AC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE90</accession>
    <name>A0A182PE90_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182PE90"/>
    <dbReference type="STRING" id="199890.A0A182PE90"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005245-RA">
        <property type="protein sequence ID" value="AEPI005245-PA"/>
        <property type="gene ID" value="AEPI005245"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005245"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000175">
        <property type="entry name" value="Serine/threonine-protein kinase 17B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF12">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="376"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005245-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="644" mass="68257" checksum="2E1D66EFC656810A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEF2</accession>
    <name>A0A182PEF2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dumpy</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PEF2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005307-RA">
        <property type="protein sequence ID" value="AEPI005307-PA"/>
        <property type="gene ID" value="AEPI005307"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005307"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048407">
        <property type="entry name" value="Dumpy_DPY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22963:SF39">
        <property type="entry name" value="DUMPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22963">
        <property type="entry name" value="ENDOGLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21164">
        <property type="entry name" value="Dumpy_DPY"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00286">
        <property type="entry name" value="PTI"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90148">
        <property type="entry name" value="DPY module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2497"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="132"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="240"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="625"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="885"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1331"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1587"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="2113"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="2168"/>
            <end position="2411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005307-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2562" mass="277356" checksum="ADCA44826110E5FE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEP2</accession>
    <name>A0A182PEP2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEP2"/>
    <dbReference type="STRING" id="199890.A0A182PEP2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005397-RA">
        <property type="protein sequence ID" value="AEPI005397-PA"/>
        <property type="gene ID" value="AEPI005397"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005397"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001440">
        <property type="entry name" value="ATPase, AAA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000038">
        <property type="entry name" value="spermatogenesis-associated protein 5-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF194">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="203"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="472"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005397-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="716" mass="79416" checksum="4DF157AC80A7E334" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEP6</accession>
    <name>A0A182PEP6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEP6"/>
    <dbReference type="STRING" id="199890.A0A182PEP6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005401-RA">
        <property type="protein sequence ID" value="AEPI005401-PA"/>
        <property type="gene ID" value="AEPI005401"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005401"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019607">
        <property type="entry name" value="Putative_zinc-finger_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10650">
        <property type="entry name" value="zf-C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative zinc-finger" evidence="3">
        <location>
            <begin position="1245"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="846"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="969"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1146"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005401-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1269" mass="141677" checksum="E60D192F710AA9D7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF03</accession>
    <name>A0A182PF03_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PF03"/>
    <dbReference type="STRING" id="199890.A0A182PF03"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005508-RA">
        <property type="protein sequence ID" value="AEPI005508-PA"/>
        <property type="gene ID" value="AEPI005508"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005508"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000534">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000135">
        <property type="entry name" value="Putative myosin light chain kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF20">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="46"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005508-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="350" mass="40464" checksum="2C66072F2F8E5B69" modified="2016-09-07" version="1">MSKRMENTARNGHGLRVILYKSWHLAPPFPFREVQLKLDVDPKQQFEILPELGRGTFGTVFHCREKATGLELAAKIVPYKKKKDRGDMVREIDIMSCLHHPRLIQLYDAFDYENKFYVILELIQGGELFERVIDDDFVLTEKACAVFMRQICEGMEYIHSRSIIHLDMKPENILCLTKTGNRIKIIDFGFARRYDPGKKLQVMFGTAEFAAPEVLNFDEIYFYTDMWSLGVICYVLLSGLSPFVGGDDQATMTNVLQGTYTFDYKSFDAVSESAKDFVRKLLVRDGEKRLTARKALRHPWLAETTAQSTTELSVTKTKLKRYVIKKRWIKAVNTIIALRRMGARIDYDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF22</accession>
    <name>A0A182PF22_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Complement component 1 Q subcomponent-binding protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAM33 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PF22"/>
    <dbReference type="STRING" id="199890.A0A182PF22"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005527-RA">
        <property type="protein sequence ID" value="AEPI005527-PA"/>
        <property type="gene ID" value="AEPI005527"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005527"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000005">
        <property type="entry name" value="Glycoprotein gC1qBP, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005527-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29510" checksum="73078278D4377B82" modified="2016-09-07" version="1">MIRNVRFLRWAAGKSFTTGKSTTTTAAVSLSQWNAGIIAQPSSGIATCSIKPISSGLNAKHGAGFSIAHRQIHTKGERELVEFLAEEIVAEKKASPSGTIPTSLNGFAITCNKADVELTKSSEREKITISFNVNHTVDMEGEEAEATENKPEFSAMKSRPQFEVDIVRGGTTLSFTCSYLPGEAQEGEYNDVFGIDEVTIFQGEWNDKVYAVAGDVLDGYLYDLLMNFLEEKGISNEFAEKMSDFASAYEHAKYVELLEAISKFTVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFG5</accession>
    <name>A0A182PFG5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 4C</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the 43S pre-initiation complex (43S PIC), which is composed of the 40S ribosomal subunit, EIF1, eIF1A (EIF1AX), eIF3 complex, EIF5 and eIF2-GTP-initiator tRNA complex (eIF2 ternary complex). Interacts with EIF5; this interaction contributes to the maintenance of EIF1 within the open 43S PIC. Interacts through its C-terminal domain (CTD) with the CTD of EIF5B; from the location of the start codon by the 43S complex until the formation of the 80S complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PFG5"/>
    <dbReference type="STRING" id="199890.A0A182PFG5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005672-RA">
        <property type="protein sequence ID" value="AEPI005672-PA"/>
        <property type="gene ID" value="AEPI005672"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005672"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005672-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="148" mass="17041" checksum="6B2B151CEF8BCB9F" modified="2016-09-07" version="1">MPKNKGKGGKNRRRGKNENESEKRELIFKEDEQEYAQVTKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINQGDIILIGLRDYQDSKADVILKYTPDEARNLKTYGEFPESVRINETVTFVENDMDDDIEFGDDYSSSEEGDAIDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGA1</accession>
    <name>A0A182PGA1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGA1"/>
    <dbReference type="STRING" id="199890.A0A182PGA1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005960-RA">
        <property type="protein sequence ID" value="AEPI005960-PA"/>
        <property type="gene ID" value="AEPI005960"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005960"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF234">
        <property type="entry name" value="CUTICULAR PROTEIN 97EA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005960-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="292" mass="31657" checksum="E42C8C8A211E15D3" modified="2016-09-07" version="1">HNEDGSYTYGYEGADGSFKIETKLATGEVKGKYGYVDETGKVKVVEYGANKYGFQPSGEGITVPPPTLVDETTGKDDLLEDDDGNVPVAPRLQKHRPASKPRFQEVPIQQHQPQRHHQPQPQQPQYYDYDEQPAPAPQPKYQPAPQYVQRSHFGASAPSQPSSPSLGPAPPRAQIPNAVPVDVVYAPKQLPARPDVEYRNVGPQTFPGAAPAPEPKIRYSQPSFAPAAGPAALPPSPKTATPAFPQPRPQPAIYQPRPAQGRSTSVLDQLAKDYALPQGGAAPLHDITFGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGI6</accession>
    <name>A0A182PGI6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGI6"/>
    <dbReference type="STRING" id="199890.A0A182PGI6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006045-RA">
        <property type="protein sequence ID" value="AEPI006045-PA"/>
        <property type="gene ID" value="AEPI006045"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006045"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="154"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006045-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="691" mass="76049" checksum="CEBD5058FC021A21" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGK7</accession>
    <name>A0A182PGK7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGK7"/>
    <dbReference type="STRING" id="199890.A0A182PGK7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006066-RA">
        <property type="protein sequence ID" value="AEPI006066-PA"/>
        <property type="gene ID" value="AEPI006066"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006066"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39942">
        <property type="entry name" value="BCDNA.LD26519-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39942:SF1">
        <property type="entry name" value="BCDNA.LD26519-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="2">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006066-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="154" mass="16362" checksum="C23C7D531DC52CFA" modified="2016-09-07" version="1">MPVCRICLTNDPLQVSLFSEYAQRKLLLTKIRVCLPITITHADTLPVTICSQCMVRLEQFYEYYCKSETSQRILTQGVGIITASGSSRTESYAVNGTAGSVSGVPTSIGTDTCVVSDNGGHGSGGGSITVADQMDPILTQSPQVKRPAVADEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGS2</accession>
    <name>A0A182PGS2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras-related C3 botulinum toxin substrate 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGS2"/>
    <dbReference type="STRING" id="199890.A0A182PGS2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006131-RA">
        <property type="protein sequence ID" value="AEPI006131-PA"/>
        <property type="gene ID" value="AEPI006131"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006131"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006131-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21807" checksum="DDA4C3BB24DFED43" modified="2016-09-07" version="1">MSSGRPIKCVVVGDGTVGKTCMLISYTTDSFPGEYVPTVFDNYSAPMVVDGVQVSLGLWDTAGQEDYDRLRPLSYPQTDVFLICYSVASPSSFENVTSKWYPEIKHHCPDAPIILVGTKIDLREDRETISLLADQGLSALKREQGQKLANKIRAVKYMECSALTQRGLKQVFDEAVRAVLRPEPLKRRQRKCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHD0</accession>
    <name>A0A182PHD0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHD0"/>
    <dbReference type="STRING" id="199890.A0A182PHD0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006339-RA">
        <property type="protein sequence ID" value="AEPI006339-PA"/>
        <property type="gene ID" value="AEPI006339"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006339"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12550">
        <property type="entry name" value="RRM_II_PABPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="93"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006339-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="221" mass="24617" checksum="D865EE530865811F" modified="2016-09-07" version="1">MADDSLLNDSNLATLGSNDDEAELLIEDDYLKGSEMQIDPELEAIKARVKEMEEEAEKLKQLQSEVTKQMTLGSPTGSTPMLTAEEKAEVDNRSIYVGNVDYGATAEELEAHFHGCGAINRVTILCNKADGHPKGFAYIEFGSKEFVETALAMNETLFRGRQIKVNPKRTNRPGMCQTNRFPRGVRGRAARVSRACCYGAHRGTRRPIRGYRGRATYYAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHF6</accession>
    <name>A0A182PHF6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHF6"/>
    <dbReference type="STRING" id="199890.A0A182PHF6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006365-RA">
        <property type="protein sequence ID" value="AEPI006365-PA"/>
        <property type="gene ID" value="AEPI006365"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006365"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006365-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="517" mass="55829" checksum="980F89CE4A23DEB5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIK6</accession>
    <name>A0A182PIK6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Golgi apparatus membrane</location>
            <topology evidence="1 5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PIK6"/>
    <dbReference type="STRING" id="199890.A0A182PIK6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006768-RA">
        <property type="protein sequence ID" value="AEPI006768-PA"/>
        <property type="gene ID" value="AEPI006768"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006768"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF43">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 5" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="6">
        <location>
            <begin position="255"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006768-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="387" mass="45098" checksum="9289297032DCDF3B" modified="2016-09-07" version="1">MKRVGLIRARLAGARLAKADVLVFLDAHCECMVQWLEPLLERIKESPTSVLVPIIDVIEAKNFYYSTNDYNDFQIGGFTWDGHFDWHDVTKRERERQKRECPEKNLEICPTYSPTMAGGLFAISRDYFWDIGSYDEQMDGWGGENLEMSFRVWQCGGTLETIPCSRIGHIFRDFHPYSFPNDRDTHGINTVRMAIVWMDDYVELLYLNRPDLKDHPELGDVTHRKVLREKLHCKSFDWYMKNVYPEKFIPTRNVRAFGRLASQADNLCLDTLQQNADKPWNLGIYTCFKPEVSASQLFSLTKRNVLRNERSCATVQASKSESKFVVMIPCIDDEDIDDTWEFTEHRQLRHKQSGLCLDSSDLSTKSYVHVATCHPGIKTQKWEFQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIX7</accession>
    <name>A0A182PIX7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIX7"/>
    <dbReference type="SMR" id="A0A182PIX7"/>
    <dbReference type="STRING" id="199890.A0A182PIX7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006890-RA">
        <property type="protein sequence ID" value="AEPI006890-PA"/>
        <property type="gene ID" value="AEPI006890"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006890"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF26">
        <property type="entry name" value="SIDESTEP III, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006890-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="233" mass="26606" checksum="457E9FB30B65ED46" modified="2016-09-07" version="1">YDVRGRQFSKALYWSETSAFGPRAYFVTISKPAALSVDNIQLDDEGVYRCRVDFQNSPTRNHRINLTVTVPPHQILVYDASGLDVTGAIGPLQEDDNLVLTCEVRGETIAPVPNALSPELLQQMERFHSQCLRETGATNEQVAQFNQPQPVEVSRELQCYMYCMFRLHNVTRPDGRLDLIDIYHAIPKQFNAIALKVLAKCHQAVVQDGDVCEQAYSQHRCWKDTEPEHYYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIX9</accession>
    <name>A0A182PIX9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIX9"/>
    <dbReference type="STRING" id="199890.A0A182PIX9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006892-RA">
        <property type="protein sequence ID" value="AEPI006892-PA"/>
        <property type="gene ID" value="AEPI006892"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006892"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF26">
        <property type="entry name" value="SIDESTEP III, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="57"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006892-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="232" mass="25690" checksum="B86CABED47C4516D" modified="2016-09-07" version="1">MQTGGGITMGRHVTVNRLEIPKMTRSALNNTYKCQASNTKLVPPAERSIRVDMLLKPLSAALSSKPKQLISNQEYVLACNVAGSVPETDIKWMQNNRPFTKGKIKLINNSSMVSSVLTFRPHPDDDGTILKCEGSNPRLQNSVLEDSVIMNVLYPPQVTLSLGSTLNPDDIKEGDDVYFECHIKANPREHRITWSHDVSTTGRGSALTHRLTTLRSPQPRQLGTVFRATALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ54</accession>
    <name>A0A182PJ54_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJ54"/>
    <dbReference type="STRING" id="199890.A0A182PJ54"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006968-RA">
        <property type="protein sequence ID" value="AEPI006968-PA"/>
        <property type="gene ID" value="AEPI006968"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006968"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF18">
        <property type="entry name" value="OVOCHYMASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0222">Digestion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131531" description="Peptidase S1 domain-containing protein" evidence="11">
        <location>
            <begin position="19"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="23"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="249"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006968-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="490" mass="54124" checksum="0B3D58E4CD5B300A" modified="2016-09-07" version="1">MKRLAFIILPAIIALGHSIRPPIIEGTEADLHEFPYQVSLQWNFNNGSRPRHICGGSIINREWILTAAHCLEEFSGNGWFEVVAGVNNIADEESGAQRRNVTRYEKHESYDTNAIRYDIGVLLLSDPLDLNQNIKTMRLAKKDTLIREKIAKFAGWGSISKTMQDIYPDKLMKVNLILRTQEDCQQMGKHVDESQICAGGYKNVTGCTADSGGPLTVTVDDEQMQIGVLSYVLVTLAALIAAKPSRPKIVGGDQAIPHEFPYQISLQWNYNNGEEDPFHFCGGSLIADRFVLTAAHCVPSEISPDGFPEAVAGEHDFSQYDAAVQRRRIAEVYVHEDYEGGVGPNDIAVFRVDQPFRLNRNVQLVKLPEPNVIPTGDCTISGWGSTSFNIFPSYPDTLMKTTIPIMDLNVCREIYAMQEVADSNICAGTMEGTSSVCSGDSGGPLVQTENEIVQVGIVSWGGVPCGGYRNPGVFVRVSYFIDWINDKINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJG7</accession>
    <name>A0A182PJG7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJG7"/>
    <dbReference type="STRING" id="199890.A0A182PJG7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007081-RA">
        <property type="protein sequence ID" value="AEPI007081-PA"/>
        <property type="gene ID" value="AEPI007081"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007081"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF104">
        <property type="entry name" value="CYTOCHROME P450 308A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007081-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41155" checksum="FB95C5EF3B7DAE5C" modified="2016-09-07" version="1">MLMSSLLLGGLFLHQPLVAVPLIALVALLYWLVKHNYKFWEIEGVPYPKPSLLTGNLGPTLSLKKHISELASDWYNAYADKPFVGYFKIFTPAIMVKDPVLVKNILTRDFDCFANNDILMDKHQDPLLAHNPTLATGDRWKRSRAMLTPSFTGAKIKQLFPVMESVADAFVTFIGRQVGQELEAKEIAARFTTQNIVACTFSIDGDCFAERESEFRRMGRRVFDTSHLATLKMMMAVFLPTVAKYIPVPFLLKEVDEWIRSLVANLIIQRSAAEGTVEEDLLQSFLKNKEKSNATQTEITAHALTIFLEGFETSSNVLGFNLYRLAKSPEVQQKLYEELKSKIDANGGRLDFDVMQQLDYLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJP5</accession>
    <name>A0A182PJP5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="37">Trifunctional enzyme subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="36">1.1.1.211</ecNumber>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="38">Monolysocardiolipin acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="39">TP-alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="45 46">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="46" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="46">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="45" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="45">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>(3S)-3-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31179"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62558"/>
            <dbReference type="ChEBI" id="CHEBI:62615"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:31180"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>(3S)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31075"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:62558"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="30">
            <dbReference type="Rhea" id="RHEA:31077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31187"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
            <dbReference type="ChEBI" id="CHEBI:62616"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:31188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:31160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:31165"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(3S)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31195"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62617"/>
            <dbReference type="ChEBI" id="CHEBI:62619"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:31196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(3S)-hydroxyoctanoyl-CoA = (2E)-octenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31199"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:62617"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:31201"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(3S)-hydroxytetradecanoyl-CoA + NAD(+) = 3-oxotetradecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
            <dbReference type="ChEBI" id="CHEBI:62614"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:31168"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43676"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83582"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:43677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43672"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83581"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:43673"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43680"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83583"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:43681"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:16107"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:20726"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) = a long-chain 3-oxo-fatty acyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:136757"/>
            <dbReference type="ChEBI" id="CHEBI:136758"/>
            <dbReference type="EC" id="1.1.1.211"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:52657"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="35">Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme. Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear. The mitochondrial trifunctional enzyme interacts with MTLN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="42">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.211" evidence="36"/>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182PJP5"/>
    <dbReference type="STRING" id="199890.A0A182PJP5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007159-RA">
        <property type="protein sequence ID" value="AEPI007159-PA"/>
        <property type="gene ID" value="AEPI007159"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007159"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016507">
        <property type="term" value="C:mitochondrial fatty acid beta-oxidation multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016509">
        <property type="term" value="F:long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000011">
        <property type="entry name" value="Fatty acid oxidation complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.50:FF:000002">
        <property type="entry name" value="Trifunctional enzyme subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012803">
        <property type="entry name" value="Fa_ox_alpha_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050136">
        <property type="entry name" value="FA_oxidation_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02441">
        <property type="entry name" value="fa_ox_alpha_mit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612:SF3">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="46" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="44">
        <location>
            <begin position="368"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="43">
        <location>
            <begin position="549"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="active site" description="For hydroxyacyl-coenzyme A dehydrogenase activity" evidence="40">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="site" description="Important for long-chain enoyl-CoA hydratase activity" evidence="41">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Important for long-chain enoyl-CoA hydratase activity" evidence="41">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="site" description="Important for hydroxyacyl-coenzyme A dehydrogenase activity" evidence="41">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00035854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00050222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00050446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00051215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00051877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00052224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00052711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00052834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00052860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00052945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00052989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00062153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00066806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00068347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00077617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00083277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="PIRSR" id="PIRSR612803-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="PIRSR" id="PIRSR612803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="43">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="44">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007159-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="771" mass="82832" checksum="672FB6E2619372E6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJZ3</accession>
    <name>A0A182PJZ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJZ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007259-RA">
        <property type="protein sequence ID" value="AEPI007259-PA"/>
        <property type="gene ID" value="AEPI007259"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007259"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131509" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007259-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="94" mass="10084" checksum="E9FD81BC09F23FF7" modified="2016-09-07" version="1">MKSPLALLIVLLLAVIALFGTTAQAACGPNPRCPADASNYLLPHPDCTQYYLCNQGTACEQSCPPGQHFNAYHRQCEAPETACCDIFVPCNPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKQ2</accession>
    <name>A0A182PKQ2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKQ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007519-RA">
        <property type="protein sequence ID" value="AEPI007519-PA"/>
        <property type="gene ID" value="AEPI007519"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007519"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007519-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="87" mass="10059" checksum="7F31B41DA00B20A8" modified="2016-09-07" version="1">MLEPKVVIMDDGLTRYVCPQCGVKYKKLSALRGHMKECGKGAQCPLCPKIVTQRRNLAKHMERHRRDGLLEFHHFIDNFPSNINLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL56</accession>
    <name>A0A182PL56_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Solute carrier family 25 member 46</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PL56"/>
    <dbReference type="STRING" id="199890.A0A182PL56"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007673-RA">
        <property type="protein sequence ID" value="AEPI007673-PA"/>
        <property type="gene ID" value="AEPI007673"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007673"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039158">
        <property type="entry name" value="SLC25A46"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252:SF2">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN SLC25A46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252">
        <property type="entry name" value="TB1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="286"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007673-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48582" checksum="30119D14EDC81D76" modified="2016-09-07" version="1">MYNHQMAGLEDYGRYLEDEDELDNARFLSAYKSTLDDAPYQFINSERDLTLPLQKHKNVQPLYESPEDEISLRKYLGASVNLISLITENLLCHPFLVLRRQCQVHHTAKRYHVVPITLLPVIVHLHQRQGVTTLWKGIGSVLLVRGMTLAVEDVISKFTPWPKEINAKTTVKQFGQHLLLKCISIAAVVPFYSASLVETVQSDIASEKPGIFDVFREGASRLLSWSVPQKGRMLPVWALVGPSISLGLSKYVCQLFVRGISTRIMCRRVTFYEERRGARTRDFAAQSQVIEVYSTMISLMATEMIFYPFETILHRIQLQGTRTIIDNLDSGYSVVPILTSYEGVVDCYRQTIATEGVSGLYKGFGAMILQFAAHVAVIKLGKWFITQISELMSSKPPAKVVEFYKLEGKTPVGSATMSRSISGISSLSEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLS1</accession>
    <name>A0A182PLS1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLS1"/>
    <dbReference type="STRING" id="199890.A0A182PLS1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007893-RA">
        <property type="protein sequence ID" value="AEPI007893-PA"/>
        <property type="gene ID" value="AEPI007893"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007893"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="5">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007893-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="114" mass="13071" checksum="3BA70D6D51E18B97" modified="2016-09-07" version="1">MENETTKPCFKKKDLSEVNPIMGKKRQWKSLKQILAHEKTLNWKETDITYSSVNAPPSLKPAKKYSDISGLVAPYTDPHSKLRYHNVEEYQTIRTFPMDLIASYLALRGATSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLS6</accession>
    <name>A0A182PLS6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLS6"/>
    <dbReference type="STRING" id="199890.A0A182PLS6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007898-RA">
        <property type="protein sequence ID" value="AEPI007898-PA"/>
        <property type="gene ID" value="AEPI007898"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007898"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF43">
        <property type="entry name" value="GEO07291P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131636" evidence="6">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007898-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="136" mass="14986" checksum="5B32B2F873C0ABCA" modified="2016-09-07" version="1">MQSLPIVFVVLLAAVSTMAFFTEEQHDIAKSLVEACRGEVSGELPEDFATRMRQGDLTLDSETSKCTIQCMFAKVGFTDADGVANRAVLITKLSKGNPTEKAEKFADVCEKNEGDSKCDKAFSLYQCYHKNKAIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLT6</accession>
    <name>A0A182PLT6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLT6"/>
    <dbReference type="STRING" id="199890.A0A182PLT6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007908-RA">
        <property type="protein sequence ID" value="AEPI007908-PA"/>
        <property type="gene ID" value="AEPI007908"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007908"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002357">
        <property type="entry name" value="Basigin, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007908-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="54210" checksum="452E93EE243A37D9" modified="2016-09-07" version="1">MRIGGGAHNKRDLNNLYQVIYYGDSQVEVGKPFSISCIISIANPVEWHKDGEPIRKHSNIRHGKDEHSYIESEMGIAGNRDKIEASISVQRALPKHQGKYQCNPLYKNYHQLYVYRNGTLLGHPGGSVAAVVVPGTEKQHRDELQLTLLSTVKSTLVAPLSVEHHHFTTAVALAPGPPVLDDEFPREHERERESPKASGHSPHHHSRQQAGAMGHRHHTGNGSGAPEKKLSSQQGKDDSKWFVSQKTTTANAEELLEQTVEGLEDFAPVLHSTDRGSVAMGKAPKHSTGTGRVQAPPPLLETHEDDDEEEDIGVDVDVVREGEAREIVNQDTGVDNVEDLVEPDTEIVIESKAISLEDENIDRLIQNKSDINGIILVDSLEELSLHKPAQAATDDHSSAMKNVSDGFPVFAIASSITPAGATSGQQAVTKEGDSGATIAPPPDHHHHHHHHEHHATTTTQTPAVTTSTSTTTTTTIATTSTTTSTTTTTVAPPPLTTIKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM57</accession>
    <name>A0A182PM57_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PM57"/>
    <dbReference type="STRING" id="199890.A0A182PM57"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008030-RA">
        <property type="protein sequence ID" value="AEPI008030-PA"/>
        <property type="gene ID" value="AEPI008030"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008030"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="16">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="163"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008030-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="441" mass="48845" checksum="C435F462AB3443A8" modified="2016-09-07" version="1">MASGSTLQKAIDIVTKATEEDRNKNYEEALRLYEHGVEYFLHAIKYEAQGDKAKDSIRAKCFQYLDRAEKLKAYLKKGKKKPVKDGDGASKDDKSKTNDSSDSDSDDPEKKKLQAKLEGAIVFEKPHVKWSDVAGLEGAKTALKEAVILPIKFPHLFTGKRMPWKGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLVSKWLGESEKLVKNLFELARAHKPSIIFIDEVDSLCSARSDNESESARRIKTEFLVQMQGVGSDNDGVLVLGATNTPWILDSAIRRRFEKRIYIPLPDEHARLVMFKIHLGNTAHTLTEDNLRTLASKTEGFSGSDISIVVRDALMQPVRKVQTATHFKQVSGPSPVDKKTICDDLLVPCSPGDSGAIEMTWVDVPGDKLFEPPVTMNDMLKSLASTKPTVNEDDMKKLDKFTEDFGQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMH8</accession>
    <name>A0A182PMH8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">cGMP-dependent protein kinase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PMH8"/>
    <dbReference type="STRING" id="199890.A0A182PMH8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008152-RA">
        <property type="protein sequence ID" value="AEPI008152-PA"/>
        <property type="gene ID" value="AEPI008152"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008152"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031775">
        <property type="entry name" value="PRKG1_interact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15898">
        <property type="entry name" value="PRKG1_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="cGMP-dependent protein kinase interacting" evidence="5">
        <location>
            <begin position="309"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="314"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008152-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="417" mass="44609" checksum="152B03A6D59CFF5B" modified="2016-09-07" version="1">MSFRSRSRTVQPIVTRRASSLTRTIAPSVNGGSALASSYAGRSYTGPSGLTGSSSYGSSGSPLAAGSYTTSSSSPYGTAVSTSSPSSRSLLGSGAGSSTNGGTYFDYSNLSRRDSYGGSSSSLAYKSPYKDKDRYGGANSYSTAGSSTGSSYKDRYVSPYTSYDNGITTASLSLSGLKGRHHHLSSNGLSGSNTSLNSSYTPSYGSSLHAGSHHHTSAGVGRSQSLRDHERRSRSRTRASQAASSAAAMSSYPSNSSLSRSYSTTSVQSEGYETGSERGRSRVGSTASELDTANQPQDSTRENGGDCIDYKALYEQEKADNDKLKMALRKKDEEVVTLKAALDRFTTATTKNNSLSELEKRERRAMERKMSEMEEELKLLQKYKTENERLRAENRALTRVVSKLTTSAQNQIHGNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMU6</accession>
    <name>A0A182PMU6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMU6"/>
    <dbReference type="STRING" id="199890.A0A182PMU6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008270-RA">
        <property type="protein sequence ID" value="AEPI008270-PA"/>
        <property type="gene ID" value="AEPI008270"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008270"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008270-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="327" mass="36235" checksum="5E4900ED89E138A1" modified="2016-09-07" version="1">MKPLMLQGHQRAITQIKYNREGDLIFSSAKDSKPCVWYSLNGERLGTFNGHIGAVWCVDVDWTTTRLITGAGDMNTFLWDVETGTALGKIPCNSSVRTCNFSFSGNQASYSTDRAMNHPCELFVIDVRNIDASISSADPVLKLTMNEQQSKITSLLWGALDETIITGHENGSLRIWDLRAVKELNSVNDHTASITDMQMSSDGTMFVSSSKDCSAKLFDSDSLMCLKTFKTERPVNSACISPLFEHVALGGGQDAMEVTTTSTQAGKFDSRFFHLVYEEEFARVKGHFGPINSMAFHPDGRSFATGGEDGFVRIQVFDSSYYEHTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNI2</accession>
    <name>A0A182PNI2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNI2"/>
    <dbReference type="STRING" id="199890.A0A182PNI2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008509-RA">
        <property type="protein sequence ID" value="AEPI008509-PA"/>
        <property type="gene ID" value="AEPI008509"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008509"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09369">
        <property type="entry name" value="LIM1_Lhx2_Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000120">
        <property type="entry name" value="Insulin gene enhancer protein ISL-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF168">
        <property type="entry name" value="PROTEIN APTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 9" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="11">
        <location>
            <begin position="131"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008509-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="188" mass="20708" checksum="2E416398057C90CD" modified="2016-09-07" version="1">MAHTHPSARFLGPPRERSPDLSNACQLNSNNNNLNHRTCISCTDTCEHSLKVAGGNGLLGVNHHLYADSCHSFESPDRLIADRPNYYADLNRSDCSDSSSVLNSCIQLKSEPPGGPSSPESSNELPPTGLDECAGCDMPIQDRFYLSAVERKWHASCLQCCICRQTLEGANSCFSRDGNIYCKTDYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNL9</accession>
    <name>A0A182PNL9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNL9"/>
    <dbReference type="STRING" id="199890.A0A182PNL9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008546-RA">
        <property type="protein sequence ID" value="AEPI008546-PA"/>
        <property type="gene ID" value="AEPI008546"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008546"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008546-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="74" mass="8792" checksum="6D330531DDFD432C" modified="2016-09-07" version="1">MPWYVPWSDVIKKKICRFLLQRYLGRFLEEKLTLDQLNVDFYNGTGTVHNVTLYCQMNSSKCQPRLLEAFVKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNX3</accession>
    <name>A0A182PNX3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNX3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008652-RA">
        <property type="protein sequence ID" value="AEPI008652-PA"/>
        <property type="gene ID" value="AEPI008652"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008652"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131723" evidence="1">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008652-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="63" mass="6847" checksum="DA587E19B917EE12" modified="2016-09-07" version="1">MKLLLVSFALLVMALALVSALPAVNDESILGGDVYEAEVDSFNPQDPQAFLKLKKLKKLLFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNZ4</accession>
    <name>A0A182PNZ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PNZ4"/>
    <dbReference type="STRING" id="199890.A0A182PNZ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008673-RA">
        <property type="protein sequence ID" value="AEPI008673-PA"/>
        <property type="gene ID" value="AEPI008673"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008673"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000980">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF24">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="22"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="368"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008673-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="502" mass="57901" checksum="A05C087D27BE2EF9" modified="2016-09-07" version="1">MAAQSGCYESVTDFFANTDVFLTGGTGFLGKVLIEKLLRSCPDLGRIFVLMRNKRGKSIETRVNELVSCPLFDRLREENKSALNKVVPIFGDITQLRLGMYEEDIQRLSNVSVAFHLAASVRFDDPLRDAIKTNISSTQELFEILKTSAHKLRAVVHVSTAYSNPENRYVEEKLYPPKYDWKKLVQAVDRYEPETLDALMQKLSHNSPNTYTYTKGLAEQVCNDYSTELPLAIVRPSVVLFTIEEPVSGWVDNFNGPTGMLVSAGLGITRTAYLRPKNRINIIPVDVVVKTIILAAWKRGTIERACGPNHLPIYNSAVTYEQSLEYQEMLDRGKEYLYAVPFSRMIWVPRGYPTNWKMLYYFKLIFTMLLPCFLLDLLIRMFGHKPFLMKLQSRIYGSELSLRYFVRNEWEFETKQTNTLPTLLNETDRNVFGWYMPRILTAKYLENAYITIRRYLLKDPDETIPYAKRKLARMILIDRIIKIIACCITVVAIWRTQFAGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPC1</accession>
    <name>A0A182PPC1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Larimer J."/>
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                <person name="Wortman J."/>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPM6"/>
    <dbReference type="STRING" id="199890.A0A182PPM6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008905-RA">
        <property type="protein sequence ID" value="AEPI008905-PA"/>
        <property type="gene ID" value="AEPI008905"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008905"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008905-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="127" mass="14065" checksum="1C849E75DFA19026" modified="2016-09-07" version="1">MTEEVNPKAYPLAEQALTSKIMTLIQQAVNYKQLRRGANEATKTLNRGLSEFIVMAADAEPIEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPIVACSVTIDEGSQLKSQIVSIQQEIERLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPP6</accession>
    <name>A0A182PPP6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Multiple epidermal growth factor-like domains protein 8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PPP6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008925-RA">
        <property type="protein sequence ID" value="AEPI008925-PA"/>
        <property type="gene ID" value="AEPI008925"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008925"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:001073">
        <property type="entry name" value="AGAP008185-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000191">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000202">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000214">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000023">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000112">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF2">
        <property type="entry name" value="DISTRACTED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
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        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="12 14" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
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    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131650" description="Multiple epidermal growth factor-like domains protein 8" evidence="17">
        <location>
            <begin position="35"/>
            <end position="3018"/>
        </location>
    </feature>
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        <location>
            <begin position="2756"/>
            <end position="2780"/>
        </location>
    </feature>
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            <begin position="43"/>
            <end position="155"/>
        </location>
    </feature>
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        <location>
            <begin position="1221"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="20">
        <location>
            <begin position="1297"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="20">
        <location>
            <begin position="1344"/>
            <end position="1394"/>
        </location>
    </feature>
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        <location>
            <begin position="1396"/>
            <end position="1531"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1529"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="20">
        <location>
            <begin position="2353"/>
            <end position="2401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2812"/>
            <end position="2874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2919"/>
            <end position="2992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="2827"/>
            <end position="2836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2837"/>
            <end position="2848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="2852"/>
            <end position="2870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2919"/>
            <end position="2930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2963"/>
            <end position="2977"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1315"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1327"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1366"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1378"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1552"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2373"/>
            <end position="2382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2385"/>
            <end position="2399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008925-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3018" mass="332344" checksum="15C6CBC33B74BF46" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQE0</accession>
    <name>A0A182PQE0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
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        <property type="protein sequence ID" value="AEPI009170-PA"/>
        <property type="gene ID" value="AEPI009170"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009170"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Blast:Probable glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000188">
        <property type="entry name" value="Ionotropic receptor 64a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF33">
        <property type="entry name" value="GLUTAMATE RECEPTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131727" description="Ionotropic glutamate receptor C-terminal domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="11">
        <location>
            <begin position="345"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009170-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="641" mass="72844" checksum="5714D0D63B285FF1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRG0</accession>
    <name>A0A182PRG0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRG0"/>
    <dbReference type="STRING" id="199890.A0A182PRG0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009544-RA">
        <property type="protein sequence ID" value="AEPI009544-PA"/>
        <property type="gene ID" value="AEPI009544"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009544"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009544-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="942" mass="104026" checksum="1B4CA97AA0343A6C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRS3</accession>
    <name>A0A182PRS3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 9">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19890"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 9"/>
    <dbReference type="AlphaFoldDB" id="A0A182PRS3"/>
    <dbReference type="STRING" id="199890.A0A182PRS3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009658-RA">
        <property type="protein sequence ID" value="AEPI009658-PA"/>
        <property type="gene ID" value="AEPI009658"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009658"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009658-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="515" mass="58215" checksum="B3C90DFCC8C911CC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRU0</accession>
    <name>A0A182PRU0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Activating signal cointegrator 1 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PRU0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009675-RA">
        <property type="protein sequence ID" value="AEPI009675-PA"/>
        <property type="gene ID" value="AEPI009675"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009675"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000272">
        <property type="entry name" value="Putative RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
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        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
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        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
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    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ASCC3_N"/>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
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        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASCC3_N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="488"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="698"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="1338"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="1550"/>
            <end position="1741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009675-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2181" mass="248608" checksum="7D45FF41A4FBB0EF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSM5</accession>
    <name>A0A182PSM5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSM5"/>
    <dbReference type="STRING" id="199890.A0A182PSM5"/>
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        <property type="protein sequence ID" value="AEPI009960-PA"/>
        <property type="gene ID" value="AEPI009960"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009960"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019098">
        <property type="term" value="P:reproductive behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10831">
        <property type="entry name" value="PDZ_CASK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000146">
        <property type="entry name" value="MAGUK p55 subfamily member 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000016">
        <property type="entry name" value="peripheral plasma membrane protein CASK isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="L27" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="53"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="140"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="270"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009960-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="457" mass="51642" checksum="A15C32F2AC3A4BDF" modified="2016-09-07" version="1">ALLHTHDVVAREVYGEEALRVTPPPIAPYLNGGNDELDNGDAGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQTVSQLQRLLRDARGSVTFKIVPSYRSAPPPVEIFVRAQFDYDPLDDELIPCAQAGIAFRVGDILQIISKDDHHWWQARHDAAGGSAGLIPSPELQEWRIACQSADKSHKEQVVNCSIFSRKKKQCRDKYLAKHNAVFDQLDLVTYEEVVKVPIGDPAFQRRTLVLLGAHGVGRRHIKNTLIAKYPDKYAYPIPHTTRPPRPDEENGRSYYFISHDEMMADISANEYLEYGTHEDAMYGTKLETIRRIHADGKMAILDVEPQALKILRTAEFTPYVVFIAAPLLQNIADYDGSLERLAKESDMLRQAYGHFFDLTIVNNDIGETIATLENAIDKVHSTAQWVPVSWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSY5</accession>
    <name>A0A182PSY5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PSY5"/>
    <dbReference type="STRING" id="199890.A0A182PSY5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010071-RA">
        <property type="protein sequence ID" value="AEPI010071-PA"/>
        <property type="gene ID" value="AEPI010071"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010071"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000004">
        <property type="entry name" value="Chitinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF360">
        <property type="entry name" value="CHITINASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="27"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010071-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="394" mass="43411" checksum="3E17752CE9BD1071" modified="2016-09-07" version="1">MAQPSALRTTPSANGLMGCQSAQWLHKPVVCYYASWAAYRPGRGQFNVEQIDPFLCTHLMYAFFGVNDSGAVTILDPWLDLDSGLGNIRRFNELRNRNPNLLTMAAVGGATVDPALFSKIAASATLRGAFARSARDFCLTHGFNGVDLGWEFPGLHDGDNANDKANFVLMLSVLAAELRSHGLLLTAALGASANIASISYDIRGIVPHLEFINLMAYDYNGAWNNFTGHNAPLFAGPSDQNDFQRILNVEHSVNYWLNQGAPASKLVLGVPAYGRSFTLSNPAVNGLRAPSVGPGLPGPYVQQYGYMAYHEICGHFLAVSNWQRVWEAVQRIPYGFLDRQWIGYDDRQSILEKCNFANSRQLGGMMMWAIDMDDFRGYCGTSYNLLKTINNCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTL9</accession>
    <name>A0A182PTL9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTL9"/>
    <dbReference type="STRING" id="199890.A0A182PTL9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010305-RA">
        <property type="protein sequence ID" value="AEPI010305-PA"/>
        <property type="gene ID" value="AEPI010305"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010305"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608:SF7">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010305-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="66" mass="6803" checksum="076FA413838DB3AF" modified="2016-09-07" version="1">MFGTVTSPPGDLGAIPCAISWLYKGINEKRQKSGARFSVRVSALGVNATKPGSSSRDLLAGHATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTZ9</accession>
    <name>A0A182PTZ9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BolA</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTZ9"/>
    <dbReference type="STRING" id="199890.A0A182PTZ9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010435-RA">
        <property type="protein sequence ID" value="AEPI010435-PA"/>
        <property type="gene ID" value="AEPI010435"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010435"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.90:FF:000001">
        <property type="entry name" value="Transcriptional regulator BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050961">
        <property type="entry name" value="BolA/IbaG_stress_morph_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46229">
        <property type="entry name" value="BOLA TRANSCRIPTION REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46229:SF2">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010435-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14665" checksum="04BB0EAF36130862" modified="2016-09-07" version="1">MLAGFCRKQLSLFNRSTFHVLRMSTAENPIENAIRAGLTKELAPVHLEVVNESYMHNVPKGSETHFKVLVVSPQFEGLPLIKRHRLVNDIVKTQLAGDFVHALSIVAKTPQQWDEAYKLEPSPNCKGGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUL7</accession>
    <name>A0A182PUL7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUL7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010654-RA">
        <property type="protein sequence ID" value="AEPI010654-PA"/>
        <property type="gene ID" value="AEPI010654"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010654"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010654-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="17025" checksum="D028BF1F62B6A90A" modified="2016-09-07" version="1">MGECDREEFYRVAVLDGTNFVAWKFRMLSLLEEHDLRECIEVELANVAALKEVAGDSSEVKSQKQRALEKHKKKDKKCKSMLISRIHDDQLEHLQGRETPKQMWDALTSIYERKMLSLVPEYDTVVTSIESQPEEQLTMDFVSSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUX4</accession>
    <name>A0A182PUX4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Uracil phosphoribosyltransferase homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUX4"/>
    <dbReference type="STRING" id="199890.A0A182PUX4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010761-RA">
        <property type="protein sequence ID" value="AEPI010761-PA"/>
        <property type="gene ID" value="AEPI010761"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010761"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000026">
        <property type="entry name" value="Uracil phosphoribosyltransferase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="34"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010761-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="226" mass="25009" checksum="BDD3E73CF588A05D" modified="2016-09-07" version="1">MCSANENNGTTSPAALSENPSDYGSNLKILDCNDQIKELQTIIRDKNTTRSDFKFYADRLIRLVIEESLNQLPYSDCSVITPTGAIYDGLRYRSGNCGVSIIRSGEAMEQGLRDCCRSIRIGKILVESDAETHVAKVVYARFPDDIARRQVLLMYPIMATGNTVIQAVSVLKDHGVKENSIILSNLFCTPIAARMVVTAFPDLKILTSELHPVAPNHFGQKYFGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV76</accession>
    <name>A0A182PV76_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PV76"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010863-RA">
        <property type="protein sequence ID" value="AEPI010863-PA"/>
        <property type="gene ID" value="AEPI010863"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010863"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010863-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="45176" checksum="F2F83B97F926E85C" modified="2016-09-07" version="1">MDLLRDNTYDIEIGNTIARRHNASFQQVLELSPKKCVDYDYSVMNLQMFLYIPLPDMTELCFVVPKSAPKSVFLVLLDPYDRFSWIAFGLTVIAISLVLFMYGESLRYTNFLLIALEMLMAVLNGPTHRLSGQFERFVIGLFMLLSIVVISGYQSLVISFMSSARYEPQLDTFNVINDTCLFMYDPQLSSLGYKFKNVHRTYEIFESTERMWSVKWCAMLTCTEAQYVMANVGDVDQLQTVDPDAIQLMDEEEWHAIKNQLKYFRYSKARIQSTTSLYRAAYDSPIRHHLAWYTQAFIEGRLEYFPVLKKSKPRAKEILEDTLDSISVQQMSMKDLMVAWILYSVGMAMSLLSFVLEQIVRCMRKIKQLIRSRNRNKRLVKKTWLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVA3</accession>
    <name>A0A182PVA3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVA3"/>
    <dbReference type="STRING" id="199890.A0A182PVA3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010890-RA">
        <property type="protein sequence ID" value="AEPI010890-PA"/>
        <property type="gene ID" value="AEPI010890"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010890"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000060">
        <property type="entry name" value="WD repeat-containing protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="750"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="850"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="890"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010890-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1164" mass="124947" checksum="E01F94FFDC73998B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWJ6</accession>
    <name>A0A182PWJ6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWJ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011333-RA">
        <property type="protein sequence ID" value="AEPI011333-PA"/>
        <property type="gene ID" value="AEPI011333"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011333"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000003">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF26">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 41 MEMBER 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="139"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011333-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="330" mass="35467" checksum="748B57A3D87D8D87" modified="2016-09-07" version="1">MCLASRLSTQANLGNMSGRREILHMILGNIALVQVQATVASFIVSMFAIIVGAIINGTIIFDHVMLLTASAMFTATSSCFVLDFVLVAVILISSKTTMNPDNLATPLAASIGDVVSISFMGGLVLDKAVGIFNGFVVFQPIINGIGGNLVSVQASKISTMLHQSSILGIIPPHARILESPWRALFHGAPYARTARILIAMSIPGQVLFIFVADYIHMTQSTIGVPFILSYLFVSTLQIMLLLYIAHIIIHLMWKWNIDPDNSAIPYLTALGDLFGSSFLMLAFLFLRSIGHPYGEKTNEIIEGFGILSTPEVKIISGGTSSDAVTNSSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWR5</accession>
    <name>A0A182PWR5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWR5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011402-RA">
        <property type="protein sequence ID" value="AEPI011402-PA"/>
        <property type="gene ID" value="AEPI011402"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011402"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011402-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="85" mass="9834" checksum="82BFA81134A400E2" modified="2016-09-07" version="1">MAKRPKWNKLTEYVEIDDIVMITYVTDEIGNWLNGRVIELQPDKDGQVSKGLTTVNKPIDFLGYHKDTNVISSKEKIKKEKIRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWT6</accession>
    <name>A0A182PWT6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWT6"/>
    <dbReference type="STRING" id="199890.A0A182PWT6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011423-RA">
        <property type="protein sequence ID" value="AEPI011423-PA"/>
        <property type="gene ID" value="AEPI011423"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011423"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF96">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="16"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011423-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="214" mass="23280" checksum="B509430DFD6C7C18" modified="2016-09-07" version="1">LANEKDETLVKEVGQSGRIINGNRVEIANFKYVVIVRGVSNFATSGGVLFQVIRIAIHPSYILDRGPGVADYNVAILRVRTNAFINRLTRIPFATAEVQIGARCLICGWGRINLRVPEPSAELRFVFMNIVSQSACSARWASSRFQTITSNMICVGSRNVDICYGDNGAPLVCNGVLVGVASFSNPSCDGSRPAGFTKIIAPNITAFIRRETRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX00</accession>
    <name>A0A182PX00_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX00"/>
    <dbReference type="STRING" id="199890.A0A182PX00"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011487-RA">
        <property type="protein sequence ID" value="AEPI011487-PA"/>
        <property type="gene ID" value="AEPI011487"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011487"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP9-like helix-turn-helix" evidence="1">
        <location>
            <begin position="88"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="2">
        <location>
            <begin position="141"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="3">
        <location>
            <begin position="303"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011487-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="83028" checksum="83311A905D230432" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX17</accession>
    <name>A0A182PX17_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PX17"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011504-RA">
        <property type="protein sequence ID" value="AEPI011504-PA"/>
        <property type="gene ID" value="AEPI011504"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011504"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="448"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1475"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2021"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1488"/>
            <end position="1504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011504-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2112" mass="234381" checksum="E24A0E99AF7DF385" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PXN3</accession>
    <name>A0A182PXN3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PXN3"/>
    <dbReference type="STRING" id="199890.A0A182PXN3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014118-RA">
        <property type="protein sequence ID" value="AEPI014118-PA"/>
        <property type="gene ID" value="AEPI014118"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014118"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014118-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="438" mass="46917" checksum="C0D44D8D0AC1ABE6" modified="2016-09-07" version="1">MLMEDRLKALERQLMPTRIQYQESTELVVPDGSNEPPSATLASEDVAVSIIHKPVSSGTTAVAGKLSRVPGELDSSLQVISLDAGSLGKNQHVVVCTSELIEDALTMQPVPATAKSLVIPVKEEKLYIKRSRSRSPTAGEATVVTLPPKKNRYPSILEAAIKAEPKVEVERIDSPSSIVVNDDQMMVSSGSHLVGTGTSLANVQQPRLNCNYRHNLETIVEAIRHLEGDAFDAVVPTQQGQQQQQQQQQKQQPPSLHQPVQQPQLQPNQPPIATSQSTIQQRPMQEVPLALTTVSKQQTPVVQTKTDRDHRQSQLEPYLKFRTAPNISAGAVVASVNPSNTTGTASNNVVTVTPQIGSIISVSIAPNGSSNLPPGSSSSHSPAVASSTTTSTIVANSSIVSVNIPQQQPHPNSLTTAAQILQQQQQCRPGVIVVKQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PY91</accession>
    <name>A0A182PY91_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PY91"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014300-RA">
        <property type="protein sequence ID" value="AEPI014300-PA"/>
        <property type="gene ID" value="AEPI014300"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014300"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131903" evidence="2">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014300-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="145" mass="15307" checksum="984CB4CB60E181BF" modified="2016-09-07" version="1">MYRLLVFIGALGVCLAYGPVACRANQTIPKVTCTPAIANQTVTQLGTFYKNLTEFTASTAKVYSCVKVNFKSAGAVNDTFAVQGCTAGTKSICRQPTFDFNGSLNCSSQNFGSSTDNSQNNHSQRPFASLLLSVAFVIGAVVIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ04</accession>
    <name>A0A182PZ04_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZ04"/>
    <dbReference type="STRING" id="199890.A0A182PZ04"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015072-RA">
        <property type="protein sequence ID" value="AEPI015072-PA"/>
        <property type="gene ID" value="AEPI015072"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015072"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF105">
        <property type="entry name" value="CYTOCHROME P450 4P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012068392" evidence="13">
        <location>
            <begin position="16"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015072-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="503" mass="58057" checksum="57FED81BD5484B6A" modified="2016-09-07" version="1">MLVAVLVFILGSCVAVLLVRDFQSKQTDGYQAALRYPGGTLMPVFGNLFELLFKNPVQTFTYARANATQYGGSYRQWIDGKVILNVTRIKEAEKILSSTQHTRKSILYRFLHPLMGDGLLCSRGAKWQQRRRILTPAFHFNILPKFLTIFQEESEKLVQQLDSFADGVQEIVLQSIVTSFALHTICETAMGVKLDVYREADEYKKKVYEVGEMLVHRTMSPWLYSDRVYRLLGYDGPLAESLKPIHHFTRSIIRQRRQNFQAAQRPDPNSEENMYFGSKQRYAMLDTLLAAEAKQQIDEEGIREEVDTFMFEGHDTTAAAIMFTIVLLANEPEAQERCYKELQDLPDRGSEKPSVQDYQNLPYLDRVIKESLRLYPSVAFISRATTGELVVDGTTFPHNTMAHIHIYDLHRDPAQFPDPERFDPDRFLPEVAEKRNPYAYLPFSAGPRNCIGQKFAQLEMKTVLVTVLQHFRIRPVTRREEIVFMADLVLRAKTPLKVRLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZB3</accession>
    <name>A0A182PZB3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZB3"/>
    <dbReference type="STRING" id="199890.A0A182PZB3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015178-RA">
        <property type="protein sequence ID" value="AEPI015178-PA"/>
        <property type="gene ID" value="AEPI015178"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015178"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF187">
        <property type="entry name" value="CYTOCHROME P450 4AE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015178-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="57826" checksum="C8AEDCA129A66A89" modified="2016-09-07" version="1">MYLLLVTTLIGIAVSWMVATIVRNRAAVSKLKDQLTNFNVIPALPLIGSAYHFKDSTSEGMFATFTGFHRRYGRSLIRQTLFNFPSMQVCDPKVIEQIMQARTIEKSIIYEFTIPWLGTGLVVSTGAKWVQRRKIITPTFHFKILEDFLVIMNHQTDVLMDNLQKVANGTDFDMYEYAAHCALNIVCESAMGVKLNTQQQPNLEYVMAVKEITDIIIKRLFSFLREHKWAFKLTKAHRRQKELVKILHDFAYKVISERKKQLQDELARLRTQEQLEEENVYGKRRMTLLDLLLNVTIDGEPLSDTDIREEVDTFMFAGHDTTSSCISLADAAIQQCVYDEIQTVVGPDAKTCELTYSTLQNLRYLEMVIKETLRINPSVPIIGRRSAGDMVIDGVTIPKGMDFAIMIHSLHNDPELYPEPSRFDPERFSEEASEMRQPYSYIPFSVGARNCIGQRYAMLEVKTILVKLVANYRLLPCDERNKLRIKTDMTLKPVNGAFVKIVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWI2</accession>
    <name>A0A3F2YWI2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWI2"/>
    <dbReference type="STRING" id="199890.A0A3F2YWI2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015425-RA">
        <property type="protein sequence ID" value="AEPI015425-PA"/>
        <property type="gene ID" value="AEPI015425"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015425"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF50">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017719737" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="37"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015425-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="280" mass="29522" checksum="EBA03B122C7AF268" modified="2019-01-16" version="1">MRKSSLVLLVVALCTSGVFSNPAVLPVVSEDAPQGRVVGGALATPGQFPYAVGLITHTGSIFTGRCAGSLISANYVLTAASCVQSATSAFAFLGGLRVDDQPEAGRERLLIERFILHSSFADGTENFDVALGQLPRSVSFTDRIRPIRLPNRRQVQATFAGQQGTVFGWGRFGSGISNSPELRFGRAEIITNLACRVSLPTNTIVDAHMCTDGSVTSPCAGDNGAPLTIVDADGITTQVGVFSFNSVLGCEAARAAVYTRLSAYLDWIGANSDVIIRDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWM3</accession>
    <name>A0A3F2YWM3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">carboxylesterase</fullName>
            <ecNumber evidence="5">3.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWM3"/>
    <dbReference type="STRING" id="199890.A0A3F2YWM3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015468-RA">
        <property type="protein sequence ID" value="AEPI015468-PA"/>
        <property type="gene ID" value="AEPI015468"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015468"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106435">
        <property type="term" value="F:carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000092">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="31"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015468-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="574" mass="64749" checksum="1C34F2CD9E444298" modified="2019-01-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZD1</accession>
    <name>A0A182NZD1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZD1"/>
    <dbReference type="STRING" id="199890.A0A182NZD1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000011-RA">
        <property type="protein sequence ID" value="AEPI000011-PA"/>
        <property type="gene ID" value="AEPI000011"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000011"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF96">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000011-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="634" mass="71246" checksum="CA1D003935FBDB16" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZZ9</accession>
    <name>A0A182NZZ9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZZ9"/>
    <dbReference type="STRING" id="199890.A0A182NZZ9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000230-RA">
        <property type="protein sequence ID" value="AEPI000230-PA"/>
        <property type="gene ID" value="AEPI000230"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000230"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15329">
        <property type="entry name" value="7tmA_5-HT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000264">
        <property type="entry name" value="5-hydroxytryptamine receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="154"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000230-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="512" mass="55430" checksum="DFBCC2A4B7DF455A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0F5</accession>
    <name>A0A182P0F5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0F5"/>
    <dbReference type="STRING" id="199890.A0A182P0F5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000387-RA">
        <property type="protein sequence ID" value="AEPI000387-PA"/>
        <property type="gene ID" value="AEPI000387"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000387"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008200">
        <property type="term" value="F:ion channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12960">
        <property type="entry name" value="Spider_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004169">
        <property type="entry name" value="Spidertoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02819">
        <property type="entry name" value="Toxin_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57059">
        <property type="entry name" value="omega toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000387-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="89" mass="9916" checksum="00770A703E78F581" modified="2016-09-07" version="1">MSAQCPVSKNDVEEGDRASLTEDGLLENYLQGGASKRSSLIQVYRRGCIPRGGNCDHRSNDCCHNSSCRCNLWGSNCRCQRMGLFQKWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0G2</accession>
    <name>A0A182P0G2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plasminogen receptor (KT)</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0G2"/>
    <dbReference type="STRING" id="199890.A0A182P0G2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000394-RA">
        <property type="protein sequence ID" value="AEPI000394-PA"/>
        <property type="gene ID" value="AEPI000394"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000394"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019319">
        <property type="entry name" value="Plg-R(KT)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13411">
        <property type="entry name" value="PLASMINOGEN RECEPTOR (KT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13411:SF6">
        <property type="entry name" value="PLASMINOGEN RECEPTOR (KT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10166">
        <property type="entry name" value="DUF2368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000394-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17656" checksum="C6862DC03D405B3E" modified="2016-09-07" version="1">MGSFFSHPTGMEVVKKNQEYISEMNKIKMERWIQMHFQIKERETAMQISRARELFYWLASFYAVSTVGLIGRFRTTKRPGTLAPIVPLSFVVAYYADLAYGTKIHRIQAEAEMIMHNEPELLEWPSGLPTVSEIDSARLDVDDKIRLHPHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0H6</accession>
    <name>A0A182P0H6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP synthase F(1) complex subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP synthase F1 subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP). Component of a complex composed at least by ATPIF1, ATP5F1A, ATP5F1B, ATP5F1C AND ATP5F1E.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0H6"/>
    <dbReference type="STRING" id="199890.A0A182P0H6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000408-RA">
        <property type="protein sequence ID" value="AEPI000408-PA"/>
        <property type="gene ID" value="AEPI000408"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000408"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.440:FF:000002">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000004">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.440">
        <property type="entry name" value="ATP synthase delta/epsilon subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036794">
        <property type="entry name" value="ATP_F1_dsu/esu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048937">
        <property type="entry name" value="ATPD_C_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21335">
        <property type="entry name" value="ATPD_C_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46604">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="18">
        <location>
            <begin position="31"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase delta subunit C-terminal" evidence="19">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000408-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="160" mass="16855" checksum="3C88A5C411E9CAFD" modified="2016-09-07" version="1">MSFALRSARLAALARPSIRMVQSRGYADEMAFTLAAANKVFYDSANIRQVDVPSFSGAFGILPKHVPTLAVLKPGVVTVYENDGAVKKIFVSSGTVTVNEDASVQVLAEEAHPVEDLDSSACRELLSNAQSQLSSASGDVDRAEAAIAIEVAEALVKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0U0</accession>
    <name>A0A182P0U0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0U0"/>
    <dbReference type="STRING" id="199890.A0A182P0U0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000522-RA">
        <property type="protein sequence ID" value="AEPI000522-PA"/>
        <property type="gene ID" value="AEPI000522"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000522"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF4">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="111"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="1">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000522-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="572" mass="63534" checksum="7D048ECC13C4A7F9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0V2</accession>
    <name>A0A182P0V2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Atrial natriuretic peptide-converting enzyme</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0V2"/>
    <dbReference type="STRING" id="199890.A0A182P0V2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000534-RA">
        <property type="protein sequence ID" value="AEPI000534-PA"/>
        <property type="gene ID" value="AEPI000534"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000534"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
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        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF146">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="13">
        <location>
            <begin position="228"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="14">
        <location>
            <begin position="378"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="695"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="886"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="383"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="391"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000534-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1066" mass="117501" checksum="D2527A1F59EA99D9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P118</accession>
    <name>A0A182P118_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="199890.A0A182P118"/>
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        <property type="protein sequence ID" value="AEPI000600-PA"/>
        <property type="gene ID" value="AEPI000600"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000600"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052872">
        <property type="entry name" value="ESR_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37372:SF1">
        <property type="entry name" value="GEO07177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37372">
        <property type="entry name" value="OS06G0316800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130652" evidence="1">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000600-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="119" mass="11563" checksum="F1ACFFF03E129511" modified="2016-09-07" version="1">MFKLVTVLSCLVVVSLAMPAVEVSQPIPIPESQDSPAVLVVQAEDDLAGAETAHHGYGGYGGGFGGGYGGGFGGYPYGGYGGGFGGGYGGGYGGFGGGYGGYGHGGFGGGYGHGHRHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P161</accession>
    <name>A0A182P161_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P161"/>
    <dbReference type="STRING" id="199890.A0A182P161"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000643-RA">
        <property type="protein sequence ID" value="AEPI000643-PA"/>
        <property type="gene ID" value="AEPI000643"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000643"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF86">
        <property type="entry name" value="CCP84AC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000643-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="230" mass="26403" checksum="7BC7DD0CAAA08CE9" modified="2016-09-07" version="1">MIWFQSNLINTSTVNSNRKLNDLSYAFGYSINNAETNDIKSQQEQRLGDAVVGTYSLLDPDGYNRTVVYKVDGDKGFQAQVIRLPVVKQKDIRETTSTTSVKHHVPKVLGLVALVFGQNHYSAHNDAQHDVVHYHHDEEHHGPAHYEYHYDVHDDHTGDVHGQHEARKDDSTHGEYYLIDADGHKRTIILALALIPAVCGQSHYGHQQHYQPQHYHHEEEHHGPVHYEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1J4</accession>
    <name>A0A182P1J4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P1J4"/>
    <dbReference type="STRING" id="199890.A0A182P1J4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000776-RA">
        <property type="protein sequence ID" value="AEPI000776-PA"/>
        <property type="gene ID" value="AEPI000776"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000776"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000112">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="24"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000776-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="383" mass="43108" checksum="521618A41D461591" modified="2016-09-07" version="1">MGANISQLERDIGSDQFPPNEHYFGLVNFGNTCYSNSVLQALYFCRPFREKVLEYKAKNRRTKETLLSCLADLFYSIATQKKKVGSIAPKKFIARLRKEKEEFDNYMQQDAHEFLNFLINHINEIILAERNQAKAGSGGAGGKGGSAGNGGMANGNAASANGTPSDTNGGGNGGSNNTEPTWVHEIFQGILTSETRCLNCETVSSKDENFFDLQVDVDQNTSITHCLRCFSNTETLCSDNKFKCDNCCSYQEAQKRMRVKKLPMILALHLKRFKYMEQYNRHIKVSHRVVFPLELRLFNTSDDAVNPDRLYDLMAVVIHCGSGPNRGHYISIVKSHGFWLLFDDDMVDKIEASTIEDFYGLTSDIQKSSETGYILFYQSRDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P210</accession>
    <name>A0A182P210_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Complex I-SGDH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase SGDH subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB5 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P210"/>
    <dbReference type="STRING" id="199890.A0A182P210"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000944-RA">
        <property type="protein sequence ID" value="AEPI000944-PA"/>
        <property type="gene ID" value="AEPI000944"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000944"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019173">
        <property type="entry name" value="NADH_UbQ_OxRdtase_B5_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SGDH SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09781">
        <property type="entry name" value="NDUF_B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000944-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="189" mass="21798" checksum="1CCE3380EB15C757" modified="2016-09-07" version="1">MAIFSSLARSGQFSARLGVLLSNPALLQASKNALTGTRSMSGGHGPKNFTITPSRFQWHKFKDMFHYYIMVGLIPVGAVVFYANVFVGPATLTETPEDYTPKHWEYHRHPITRFIARYILPNPQQEYEKMLHHVYEENEKAQIRALEKEVRAKMAERNDYQSYYYRPAIGKYHRVAKEAADELEALRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2J2</accession>
    <name>A0A182P2J2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras association domain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
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    <dbReference type="AlphaFoldDB" id="A0A182P2J2"/>
    <dbReference type="STRING" id="199890.A0A182P2J2"/>
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        <property type="gene ID" value="AEPI001126"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI001126"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033593">
        <property type="entry name" value="N-RASSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286:SF6">
        <property type="entry name" value="GH01133P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="187"/>
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            <end position="246"/>
        </location>
    </feature>
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            <begin position="292"/>
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            <begin position="461"/>
            <end position="488"/>
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            <begin position="568"/>
            <end position="623"/>
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        <location>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001126-PA"/>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="71328" checksum="D58679799B9F73EE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P341</accession>
    <name>A0A182P341_9DIPT</name>
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        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="ABC_transporter_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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            <dbReference type="PROSITE" id="PS50893"/>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="488" mass="54323" checksum="DB8FA3B08DCEA63B" modified="2016-09-07" version="1">YSSIAYVPQKAWLQNATIRENVLFGESFRPKRYDRVLRACALRPDLDLMPAGDGTEIGERGLKLSGGQRQRIAIARALYSSANVVILDDPLSALDNEVAMDVFENGVHRMLARQKRTIILVTQKVQLVHRADNIVVMEGGAISATGSLTEIENNYPHILREWNAIIAKEQQQSSEAQSSPGRTARERWKLFKNISRISFQRNHATEENDFMERTFYFPRTMANRALFGSRLSAHDFPLPIEDCHEPNVALRRHYSNRLRKDSPPSSTAVVLRRSPLGPIDPSGTGHQSVFRALSLQLGTSTSTGANAPAGANQRQQRQPAVVVRHISFPTTLTTSSGSSACAGALDDRLFSRLRDAEQLVGGSTGQRRIPDGMDDTGTVVVDGTEPSRATGVQCGQNDGRNSCEDLKRSSIGFRIPEFLRRMSARGRRFSNPTEFGRPYREREDGSRKSSRKTSSLKSIPKERHYSIKRLLSTISRQSEDTEESSVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P385</accession>
    <name>A0A182P385_9DIPT</name>
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        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P385"/>
    <dbReference type="STRING" id="199890.A0A182P385"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001369-RA">
        <property type="protein sequence ID" value="AEPI001369-PA"/>
        <property type="gene ID" value="AEPI001369"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001369"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF3">
        <property type="entry name" value="ODORANT RECEPTOR 30A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001369-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="374" mass="43365" checksum="80F49D2B6BC5ACCC" modified="2016-09-07" version="1">MEVLNCPLLSVNVRVWRFWSFVLVHNWRRYISIIPVTALNVFMFADLYRAWGNIEEVIINAYFAVLYFNAVLRALILVYHRDRYESFLAGAASVYEEIRALNDDAITKLVTTYTKRARFLSISNLALGAFISGCFVVYPLFTGQRGLPYGMFIPGVNNFDSPQYEIFYITQLVLTFPGCCMYIPYTSFFASSTLFGLVQIKTLQHQLNHFRSENLTESTDTLNRRLEKLIEDHKRIIRYVKDLNDLVTYICLIEFLSFGLMLCALLFLLNIISVMAQIVIVGAYIFMILTQIFAFYWHSNEVREESMAIAQAAYSGPWLNVDNSIKKKLLLITIRAQRPLEITVGNVYPMTLEMFQSLLNASYSYFTLLRRVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3L4</accession>
    <name>A0A182P3L4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peregrin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3L4"/>
    <dbReference type="STRING" id="199890.A0A182P3L4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001499-RA">
        <property type="protein sequence ID" value="AEPI001499-PA"/>
        <property type="gene ID" value="AEPI001499"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001499"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15670">
        <property type="entry name" value="ePHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15572">
        <property type="entry name" value="PHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05839">
        <property type="entry name" value="PWWP_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="243"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="297"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="599"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="14">
        <location>
            <begin position="1044"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="790"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="895"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="979"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="898"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="988"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001499-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1166" mass="129001" checksum="8979B7F62FF1D3B1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4K1</accession>
    <name>A0A182P4K1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 231</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM231 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4K1"/>
    <dbReference type="STRING" id="199890.A0A182P4K1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001837-RA">
        <property type="protein sequence ID" value="AEPI001837-PA"/>
        <property type="gene ID" value="AEPI001837"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001837"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019306">
        <property type="entry name" value="TMEM231"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605">
        <property type="entry name" value="CHST5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10149">
        <property type="entry name" value="TM231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001837-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="329" mass="38005" checksum="158D84410670BFB7" modified="2016-09-07" version="1">MKLFSFYNKSIYIQYRNQLCSTTTFVVCALSVAAFVAPYYLLSSIKHGELWDQHRTVYEQPKMAFQYSYLFLAEMDQPEEGRAPTVVTCSSFPSYNTLTEQLQPCSDVQVVPIDTNHDHTLDRLSVSVRFNPPERGFRLSFYTFYFFLEATLSSQCRFTVPAFVALEKVPPPVRSFEYGTIVHSGAMVARQSVALQCPFFMRQQKSHFSDRYYPNDNTTLEGFQPSVIRAKIEGSNPAYFEYRAQSTSWTVDGSGSIRVQIDVSIGGKDSTLVAFLYNTSIWWKLCQLWASYFPLLLVSLWLTAKVKQYLFENFYLRAVEVVPWKNKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5E3</accession>
    <name>A0A182P5E3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pickpocket</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5E3"/>
    <dbReference type="STRING" id="199890.A0A182P5E3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002133-RA">
        <property type="protein sequence ID" value="AEPI002133-PA"/>
        <property type="gene ID" value="AEPI002133"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002133"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002133-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="64177" checksum="17B47626E576BB2C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5W3</accession>
    <name>A0A182P5W3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5W3"/>
    <dbReference type="STRING" id="199890.A0A182P5W3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002304-RA">
        <property type="protein sequence ID" value="AEPI002304-PA"/>
        <property type="gene ID" value="AEPI002304"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002304"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002304-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1190" mass="130432" checksum="4A72EFAA9A883FD6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P635</accession>
    <name>A0A182P635_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P635"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002381-RA">
        <property type="protein sequence ID" value="AEPI002381-PA"/>
        <property type="gene ID" value="AEPI002381"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002381"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029138">
        <property type="entry name" value="SNAPC5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15497">
        <property type="entry name" value="SNAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002381-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="110" mass="12285" checksum="E2624BB71644E828" modified="2016-09-07" version="1">MESSSSQYSSLIKEQRQLKKAETILQSMIDKINHELNQLVVEELQIKSRDAQLSIETSGAKAAKPAPLIDDASCSNIEQINQQTLNLEVQDDKLLKSLEESEDELDDLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P640</accession>
    <name>A0A182P640_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Odorant-binding protein 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P640"/>
    <dbReference type="STRING" id="199890.A0A182P640"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002388-RA">
        <property type="protein sequence ID" value="AEPI002388-PA"/>
        <property type="gene ID" value="AEPI002388"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002388"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF42">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130954" description="Odorant-binding protein 13" evidence="5">
        <location>
            <begin position="25"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002388-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16417" checksum="625AD0965FEB089A" modified="2016-09-07" version="1">MKLSNALVALSFAMLATAVVSVQADNAEEMEQAKEMLRGLAADCKTKEGATDEDVDGFVNDKMPESRTQKCLAGCMQEQFGISDGKAFQQDGFVEIAKMLMKGDEAKIEMARKIAADCKDVTHDDRCELAVEILNCLKESAEKHGIELKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6F4</accession>
    <name>A0A182P6F4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6F4"/>
    <dbReference type="STRING" id="199890.A0A182P6F4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002502-RA">
        <property type="protein sequence ID" value="AEPI002502-PA"/>
        <property type="gene ID" value="AEPI002502"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002502"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000249">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF89">
        <property type="entry name" value="FI02132P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="95"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002502-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="568" mass="62439" checksum="F2E455FE31F4EB23" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6H2</accession>
    <name>A0A182P6H2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="4"/>
    <dbReference type="STRING" id="199890.A0A182P6H2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002520-RA">
        <property type="protein sequence ID" value="AEPI002520-PA"/>
        <property type="gene ID" value="AEPI002520"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002520"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10810">
        <property type="entry name" value="GH38N_AMII_LAM_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000002">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000018">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1360:FF:000005">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000001">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1360">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048534">
        <property type="entry name" value="Man2a1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21260">
        <property type="entry name" value="Laman-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130969" description="alpha-mannosidase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="13">
        <location>
            <begin position="369"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="13">
        <location>
            <begin position="1391"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002520-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2092" mass="238577" checksum="2B0B81DF4C5A8254" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6T6</accession>
    <name>A0A182P6T6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transmembrane protein 181</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6T6"/>
    <dbReference type="STRING" id="199890.A0A182P6T6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002636-RA">
        <property type="protein sequence ID" value="AEPI002636-PA"/>
        <property type="gene ID" value="AEPI002636"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002636"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040416">
        <property type="entry name" value="TMEM181"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054077">
        <property type="entry name" value="TMEM181_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21885">
        <property type="entry name" value="TMEM181_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM181 GOLD" evidence="8">
        <location>
            <begin position="128"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="7">
        <location>
            <begin position="252"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002636-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="64420" checksum="727A834A08BDFBB4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6T9</accession>
    <name>A0A182P6T9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Single-minded</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6T9"/>
    <dbReference type="STRING" id="199890.A0A182P6T9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002639-RA">
        <property type="protein sequence ID" value="AEPI002639-PA"/>
        <property type="gene ID" value="AEPI002639"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002639"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AGAP000773-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="single-minded homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="bHLH_dom"/>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
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    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF36">
        <property type="entry name" value="PROTEIN SINGLE-MINDED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
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            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="383"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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            <end position="786"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="998"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1082"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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        </location>
    </feature>
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    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002639-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1110" mass="118140" checksum="7357CE76077B358B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P739</accession>
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        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
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    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTP_cat"/>
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        <property type="entry name" value="Tyr_Pase_AS"/>
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    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
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    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46257">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE CORKSCREW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46257:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE CORKSCREW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="241"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002741-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="378" mass="43128" checksum="0BBFBEB52F734CF0" modified="2016-09-07" version="1">MAVDHTRVKLKDVDSSVPGADYINANYIRQPTEAEQNDMSSSSENLTQSGSLNNGYSQPNATNNNGTNGNSNVGPMQPTKNCSSCLLLNKPCSQCSLKANSEMKHKRNESITSRMQLQQQSPHKRDEKDMFKTYIATQGCLTNTIQDFWNMIWQENTRVIVMTTKEMERGKKKCEKYWPDPQQSKEWGHARVRCLSETSTADYTLREFLLSWRGQEDRKIYQYHFQVWPDHGVPADPGCVLNFLQDVNTRQAQLQLEGLMPGPICVHCSAGIGRTGTFIVIDMILDQILRQGHECEIDIQRTIQMVRSQRSGMVQTEAQYKFVYFAVQHYIQTLLQRKQAEQQSLQVGREYTNIKSTSDSQLPLPRTVNDLNNSLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7M4</accession>
    <name>A0A182P7M4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7M4"/>
    <dbReference type="STRING" id="199890.A0A182P7M4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002927-RA">
        <property type="protein sequence ID" value="AEPI002927-PA"/>
        <property type="gene ID" value="AEPI002927"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002927"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002927-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="333" mass="37677" checksum="A2F33E43E6C6601A" modified="2016-09-07" version="1">MFLPFAASTRQQRTAKMSDAEADAHASTNGSATNGGPAPPAPLLPSQKVLEEEEAERLAEEERKRNREPPIIFTEVDSKLELERLVDFVDGKLSEDEQEAVDQLHQYLLLGEGAWTFGDCFLVFVGRIFRDQQCFSTDVRVHLLRALANCALKEDIILLLHQDRKEHVLMNFAQDIDRHPPEEQQSIALFMCNLFENNNASEWLLYISEWNYNGLTTSNIRATTKVAVHCLLATCPRLQDIGTALVHNIACKEVKTVVFDDVAVEISMALLQFFNSSPTEEHLFRTMKALAKFVQVSPDVPQFVQMIGPHPKNFKGKSERVDVLIDQISKKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7U3</accession>
    <name>A0A182P7U3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7U3"/>
    <dbReference type="STRING" id="199890.A0A182P7U3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002996-RA">
        <property type="protein sequence ID" value="AEPI002996-PA"/>
        <property type="gene ID" value="AEPI002996"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002996"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002996-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16290" checksum="C9F1735A00AB9184" modified="2016-09-07" version="1">MFSFFKSKKPSPTQVPADPIPGAGSPAVPPPTREDDFIFIERRGGPQPADDTTAAGGSTPGGTPSRASGLYPSVPEPPTIGSTAGNPVPVRQRSDEKVAGHALHGVPFRLSTDIGQPADMEITRIQANEILTYAGRVMYTPGYDFSLERSVLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8A9</accession>
    <name>A0A182P8A9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4,8-dimethylnonanoyl-CoA + (R)-carnitine = O-4,8-dimethylnonanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:44860"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77061"/>
            <dbReference type="ChEBI" id="CHEBI:84654"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8A9"/>
    <dbReference type="STRING" id="199890.A0A182P8A9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003162-RA">
        <property type="protein sequence ID" value="AEPI003162-PA"/>
        <property type="gene ID" value="AEPI003162"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003162"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000001">
        <property type="entry name" value="carnitine O-palmitoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF16">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="11">
        <location>
            <begin position="50"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003162-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="665" mass="74268" checksum="240E363113F05FCF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8J2</accession>
    <name>A0A182P8J2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P8J2"/>
    <dbReference type="STRING" id="199890.A0A182P8J2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003245-RA">
        <property type="protein sequence ID" value="AEPI003245-PA"/>
        <property type="gene ID" value="AEPI003245"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003245"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.700.20:FF:000001">
        <property type="entry name" value="AMME syndrome candidate gene 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.150">
        <property type="entry name" value="Hypothetical protein ph0010, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="107"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003245-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="316" mass="34769" checksum="ED1AB8CA59F5FC48" modified="2016-09-07" version="1">MSSSCCGTKKQKLNGNYSTGANGYCSSSTNKAGAQRNNGIADGAATQNNHSYHGRGSAGSNNGGGGGGGGGQQSSSSSSSSSSSSSSAGGYNGGYLMNGHGNHLSQQQQSMIGSMSDMCFYCFEVLYRELHNLEEPRTPCFTNDPYPLFVTWKIGKDKRLRGCIGTFSAMRLHSGLREYAITSALRDSRFSPITRDEIQRLTVSVSILQGFEEARGYLDWTLGIHGIRIEFYNERGSKRTATYLPQVATEQGWDQTQTIDSLLRKGGYRAQITPETRRSIKLTRYTSQECQMSYNEYRDLLEKQSHYHGQLCKMQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8J9</accession>
    <name>A0A182P8J9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SS18 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SS18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8J9"/>
    <dbReference type="STRING" id="199890.A0A182P8J9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003252-RA">
        <property type="protein sequence ID" value="AEPI003252-PA"/>
        <property type="gene ID" value="AEPI003252"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003252"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007726">
        <property type="entry name" value="SS18_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23107:SF0">
        <property type="entry name" value="IP09280P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23107">
        <property type="entry name" value="SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05030">
        <property type="entry name" value="SSXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SS18 N-terminal" evidence="9">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="449"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="531"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003252-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="707" mass="70776" checksum="9420A5819D9420D7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8S3</accession>
    <name>A0A182P8S3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MyTH4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8S3"/>
    <dbReference type="STRING" id="199890.A0A182P8S3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003327-RA">
        <property type="protein sequence ID" value="AEPI003327-PA"/>
        <property type="gene ID" value="AEPI003327"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003327"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13201">
        <property type="entry name" value="FERM_C_MyoXV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041795">
        <property type="entry name" value="MyoXV_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MyTH4" evidence="8">
        <location>
            <begin position="230"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="386"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003327-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="78531" checksum="B0E92BD2D56F2A4C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA76</accession>
    <name>A0A182PA76_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import receptor subunit TOM70</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PA76"/>
    <dbReference type="STRING" id="199890.A0A182PA76"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003830-RA">
        <property type="protein sequence ID" value="AEPI003830-PA"/>
        <property type="gene ID" value="AEPI003830"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003830"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="436"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003830-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="64257" checksum="A6625F478295CB7E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAA3</accession>
    <name>A0A182PAA3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Ras-related protein Rab-35</fullName>
            <ecNumber evidence="8">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="27" key="4">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Melanosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A182PAA3"/>
    <dbReference type="STRING" id="199890.A0A182PAA3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003857-RA">
        <property type="protein sequence ID" value="AEPI003857-PA"/>
        <property type="gene ID" value="AEPI003857"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003857"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000404">
        <property type="entry name" value="Putative ras-related protein Rab-35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0168">Coated pit</keyword>
    <keyword evidence="23" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="14" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0636">Prenylation</keyword>
    <keyword evidence="17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003857-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="202" mass="23142" checksum="BDC3498DE4DF4770" modified="2016-09-07" version="1">MAREYDHLFKLLIIGDSGVGKSSLLIRFSDNTFSGSYITTIGVDFKIRTVVINGERVKLQIWDTAGQERFRTITNTYYRGTHGVIVVYDVTNGESFGNVKRWLQEIESNCDIVNKVLVGNKNDDPTRKVVTTEDAERFANQMEIKLFETSAKDNLNVEEMFLAITEQVLRHKKQTQKQQQSETNNDTVQLKKGTHKKKNKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAD0</accession>
    <name>A0A182PAD0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGTA homodimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAD0"/>
    <dbReference type="STRING" id="199890.A0A182PAD0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003884-RA">
        <property type="protein sequence ID" value="AEPI003884-PA"/>
        <property type="gene ID" value="AEPI003884"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003884"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001336">
        <property type="entry name" value="AGAP003052-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000013">
        <property type="entry name" value="LD24721p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="6">
        <location>
            <begin position="11"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003884-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="327" mass="36338" checksum="258ACFACABDD23BE" modified="2016-09-07" version="1">MSDSGISVDAKYFVRSFIRFLAKQIDQPNFNEDSRESIEVAIQCLENVYELNDGEAATGGEGSVKKEDDPRNHVDLYELYCNTYVEVSAERKQEAEGLKNEGNRLMKEEKYQEALNTYTKAINLDGTNPVFYCNRAAAYSRLGDYVRAADDCRMALRHDPNYSKAWGRLGLAYSKMNEHKQAVTAYQNAIRLEPDNQDYKNNLSVSQQSLEERSRNPGAAAGGGGANPLANIDFASVINNPDMVQMATRMMSDPAMHNILGQLGGMNNMDALLETGRRLAMQMSSENPELFNNVARQMEQAGINLPRNNPPNPDGNQQPPPPPPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAZ1</accession>
    <name>A0A182PAZ1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="21">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="20">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18 21">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="21"/>
    <dbReference type="AlphaFoldDB" id="A0A182PAZ1"/>
    <dbReference type="STRING" id="199890.A0A182PAZ1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004096-RA">
        <property type="protein sequence ID" value="AEPI004096-PA"/>
        <property type="gene ID" value="AEPI004096"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004096"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000143">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 21" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 21" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="787"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="882"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="954"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="22">
        <location>
            <begin position="76"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="738"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004096-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="973" mass="106533" checksum="C1E64061A5F521DD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBD8</accession>
    <name>A0A182PBD8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tigger transposable element derived protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBD8"/>
    <dbReference type="STRING" id="199890.A0A182PBD8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004243-RA">
        <property type="protein sequence ID" value="AEPI004243-PA"/>
        <property type="gene ID" value="AEPI004243"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004243"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF16">
        <property type="entry name" value="JERKY PROTEIN HOMOLOG-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="73"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004243-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="564" mass="64191" checksum="BFD22EBD819D2459" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC38</accession>
    <name>A0A182PC38_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC38"/>
    <dbReference type="STRING" id="199890.A0A182PC38"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004493-RA">
        <property type="protein sequence ID" value="AEPI004493-PA"/>
        <property type="gene ID" value="AEPI004493"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004493"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF44">
        <property type="entry name" value="ODORANT RECEPTOR 13A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004493-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="398" mass="45785" checksum="EAF8210ACB4ED98C" modified="2016-09-07" version="1">MQPAVGLVRFESFIRVPEIFFAMIGVARYGEPKRTLRAYLKHLLFWSSCINTGFCLIIEHIYFVKAAGNFTNFLQLTALAPCMGFTALSFVKIMTIKLNEAKLTDMLHRLDALFPKTVALQERYGVFQYNRESQVVMKSFSILYMILIWMFNLLPLVSMLEGYVTQGKWHKQLPYFMWYWYDWHLPGYFEVTFLHQNWGGFVSAVFYLSTDLMFCAIVLLLCLQFDIVAYRLKHALPDDHQELEGCVRIHQAVIELCNELEHMFSPSLLVNFLSSSVIICLVGFQATAGITPADLFKFVLFLVSSLVQVFLLCYYGNKLIVASSQIPYSAFEGHWIGASISYQRSLLFVMLRSTTVQKLTALKFSIVSLASYSKILSTSFSYFTLLKAIYEPNEKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCJ6</accession>
    <name>A0A182PCJ6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
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            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI004651"/>
    <dbReference type="Proteomes" id="UP000075885">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000123">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
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        <property type="entry name" value="N-acetyl transferase-like"/>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
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    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF217">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21524">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52014">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAMD1-like winged helix (WH)" evidence="24">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
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        <location>
            <begin position="87"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="252"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="23">
        <location>
            <begin position="438"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
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            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
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            <begin position="310"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
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            <begin position="398"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
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            <begin position="753"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
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            <begin position="995"/>
            <end position="1420"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
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            <begin position="1496"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="167"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
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            <begin position="398"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="766"/>
            <end position="796"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="945"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1040"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
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            <begin position="1089"/>
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            <begin position="1170"/>
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        </location>
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            <begin position="1230"/>
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        </location>
    </feature>
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        <location>
            <begin position="1255"/>
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            <begin position="1310"/>
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        </location>
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            <begin position="1374"/>
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        <location>
            <begin position="1501"/>
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        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="18">
        <location>
            <position position="614"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS52014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004651-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1535" mass="168469" checksum="9016786F8E56DE6D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCZ1</accession>
    <name>A0A182PCZ1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCZ1"/>
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        <property type="protein sequence ID" value="AEPI004796-PA"/>
        <property type="gene ID" value="AEPI004796"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI004796"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004796-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="182" mass="20295" checksum="FEC58E052860AE2A" modified="2016-09-07" version="1">MRTKSNVRFIPKVLDLTQRQDQLLPATAVEEPQSVQETVKTMNTNHHTDIANSAAKVRKVRAKKHQAVGKPPSSKQRSKRTLNGPAGVPVPSVQPIGPTSILYQFDLTQRINQKLRMLEDRQKLMHIVHASTGNNMLGDDYPSLHGWNRQQTVPLEFPITPIALSHVRETASVAVYVPVTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD17</accession>
    <name>A0A182PD17_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PD17"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004822-RA">
        <property type="protein sequence ID" value="AEPI004822-PA"/>
        <property type="gene ID" value="AEPI004822"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004822"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004822-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="280" mass="31501" checksum="A03049EB27F50E06" modified="2016-09-07" version="1">MNNEELALSNESGFQGDWKSIFHRDALIWASHEYDTDSIMKPLAEFVFTLSSQFRLSPAIEFTTIDTLELLLVRAFQGWMQTSSTFPDAFERHKTAFLRQLPLYVVAVFDIVTKYNNLGLKLDLAAMKRAAKVSGSTSANMLSVEFEVIKILDSELRSSLLLGAFERFCKEYLLPLNIESKEVIGSIGMKLLRLAVAERALVYDSLKTSMKDKECFRRFKSNKLILAGAIIITILYLIPATRNSNAILNQVVVPLADDCCVQATNLIYLRDALLRVIGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD83</accession>
    <name>A0A182PD83_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA-processing protein FCF1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PD83"/>
    <dbReference type="STRING" id="199890.A0A182PD83"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004888-RA">
        <property type="protein sequence ID" value="AEPI004888-PA"/>
        <property type="gene ID" value="AEPI004888"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004888"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="8">
        <location>
            <begin position="72"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004888-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="204" mass="23903" checksum="CE592CCB8FE0D327" modified="2016-09-07" version="1">MGNKNQVKRLQQQRSGLLRRMIKSTDSRLKPTDRSKAKPKKKRDDDEPKVIERPQGSSAMFFQYNTQLGPPYHILVDTNFVNFSIKNKLDIIKTMMDCLYAKCIPYITDCVVAELEKLGQKYKLALRIIKDPRFERLHCMHWGTYADDCLVQRVTQHKCYIVATNDKDLKRRIRKIPGVPIMNVALNRYVIERMPDAFEPMAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDE4</accession>
    <name>A0A182PDE4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aromatic-L-amino-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDE4"/>
    <dbReference type="STRING" id="199890.A0A182PDE4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004949-RA">
        <property type="protein sequence ID" value="AEPI004949-PA"/>
        <property type="gene ID" value="AEPI004949"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004949"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004058">
        <property type="term" value="F:aromatic-L-amino-acid decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF60">
        <property type="entry name" value="3,4-DIHYDROXYPHENYLACETALDEHYDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004949-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54518" checksum="45796015AAE75269" modified="2016-09-07" version="1">MLPAELQNEPEDWKTIMEDFKRCILPGLTHWQSPHFHAFYPSQTSYSSIVGETLAAGLGVVGFSWICSPVCTELEVIMMNWLGQLLNLPKAFLNCGEGNGGGIIQGSASESILVAVLAAREQAVRRLRVQHPDLTEAEIRGRLVAYTSDQSNSAVEKAGILGAIKMRLLPADETSILRGSTFIQAVEEDVANGLFPVICVATLGTTGTCAYDNLAEIGPYCNEHNIWLHIDAAYAGAALCLPEYTHIMHGAERADSLNFNLHKWMFVNFDCCAMWFKDAGSVTKSFSVDRIYLQHQFQGHSKAPDYRHWQIQLGRRFRSLKVWITLRTMGAEKIRELIRFHIQLANRFEQYVRTDERFEVLCSTLALVCFRLKGDDARSKQLLENITKRKKIFMIPATYQGKFIIRFMICGIDPQMHDIEYAWDEVRSQADLLLDVDRNRNEVTQAIESDAPEEPKVYEKSCEIGKITESLTGIVLSNDEKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDG6</accession>
    <name>A0A182PDG6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDG6"/>
    <dbReference type="STRING" id="199890.A0A182PDG6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004971-RA">
        <property type="protein sequence ID" value="AEPI004971-PA"/>
        <property type="gene ID" value="AEPI004971"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004971"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004971-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26533" checksum="6175482D2C277375" modified="2016-09-07" version="1">MTMSTNNCESMTSYFTNSYMNSDMHGHYPGTGVDGLDTSQQMYSHHNQTHANQANMPPYPRFPPYDRMGYYQQTMDPAGYARADSPSSQVGGVIPPQTNGNPLQQTQVQPQQQQPIVYASCKLQAAVGNGPNGLGTYGTENGSPPLEQMGHHMGTAQMTIPQHHMGHSQGQDCYPEQVHQNPQHMAMYTNAGGGPPGVPQQPPNMMHQQPPQLHQGQQPPPNSQSASSGLQSPLYPWMRSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDX2</accession>
    <name>A0A182PDX2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDX2"/>
    <dbReference type="STRING" id="199890.A0A182PDX2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005127-RA">
        <property type="protein sequence ID" value="AEPI005127-PA"/>
        <property type="gene ID" value="AEPI005127"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005127"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.580:FF:000001">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016820">
        <property type="entry name" value="Mediator_Med6_met/pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023869">
        <property type="entry name" value="Mediator_MED6_meta/pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005127-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="267" mass="29782" checksum="0F22CF741175B3E0" modified="2016-09-07" version="1">MNPGRLGLAPLVQENPLWISWHDSNWIPVLNPGNVMDYFSEKSNPFYDRTCNNEIVRMQRQSLELLNNMTGVEYIPLHVQDPILYVIRKQHRHSPTEATPMADYYIIAGTVYQAPDLASVFNSRILSTVHHLQTAFDEASSYSRYHPSKGYSWDFSSNKAIAEKTKTQTKKEAPVKEEPSSIFQRQRVDMLLGDLLRKFPLPLPQMTNNSAGANPSEASNAAANHSSGTGESDHVGADSTLIKQEPTEAGVGRGSSNDAPPEKKMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE49</accession>
    <name>A0A182PE49_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PE49"/>
    <dbReference type="STRING" id="199890.A0A182PE49"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005204-RA">
        <property type="protein sequence ID" value="AEPI005204-PA"/>
        <property type="gene ID" value="AEPI005204"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005204"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005204-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="227" mass="25967" checksum="2F8A4CAEB63F6C52" modified="2016-09-07" version="1">MEDSRYLPNQTEQNSVQEDELRHELLKYYRTSLIIGLLKQPDAPISTECRALLSMYKHDGELPLGMDHLRNVECSYHERVAIGKYIETKITEQVQPLVEKAKRHCGGNLEELSAPQFKEQYNNLQLSRERQELTEKLAQLKSRKLHLMKACTEIRNGPHQRNNVELKHAAARSMQTKAELLQKLVANEIVNCTPHTPKVIKEVSANINTQLGDGRGESDPRGPKPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE89</accession>
    <name>A0A182PE89_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PE89"/>
    <dbReference type="STRING" id="199890.A0A182PE89"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005244-RA">
        <property type="protein sequence ID" value="AEPI005244-PA"/>
        <property type="gene ID" value="AEPI005244"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005244"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000437">
        <property type="entry name" value="Beat-IIIc, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF8">
        <property type="entry name" value="BEATEN PATH IA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005244-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="130" mass="14584" checksum="6ED81F64AFC52739" modified="2016-09-07" version="1">MDGESLYSVKWYKGRREFYRYTPKESPPMKIFPAQGVQVKRSASNESQLTLLGLSLASSGKYSCEVSADAPSFHTMIVTGDLEVCEVPKHVPSIHGMRSRYRVGDIVRGNCTSHNSRPPANLTWYINEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PED5</accession>
    <name>A0A182PED5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Iron hydrogenase small subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PED5"/>
    <dbReference type="STRING" id="199890.A0A182PED5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005290-RA">
        <property type="protein sequence ID" value="AEPI005290-PA"/>
        <property type="gene ID" value="AEPI005290"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005290"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase small subunit" evidence="6">
        <location>
            <begin position="412"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005290-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="478" mass="53902" checksum="A1F040B6DE4AF925" modified="2016-09-07" version="1">MSRFSSALQLTDLDDFITPSQECIKPVKIETSKSKTGAKITIQEDGSYVQESTSGIQKLEKVEITLADCLACSGCITSAEGVLISQQSQEELLRVMNANNLAKLNNQRDEIKFVVFTVSQQPILSLARKYNLSPEDTFEHIAGYFKKLGADMVVDTKIADDLALIECRNEFVERYNTNRKTLPMLASSCPGWVCYAEKTHGNFILPYIATTRSPQQIMGVLIKQYLAKVLQTTGDRIYHVTVMPCYDKKLEASREDFFSEVENSRDVDCVITSIEIEQMLNSLGLQTLQLVEKSPIDWPWPTARPPAFVWGHESSGSGGYSEHIFKYAARKLFNVAVDTVEFKPLRNNDMREAVLEQNGQVVMRFAIANGFRNIQNMVQKLKRGKSTYDYVEIMACPSGCLNGGAQIRPEEGKTARELTAELENMYRSLPQSNPENESVETMYATFLDSEGDLNKRQSLLHTSYHQIEKINSALNIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEQ4</accession>
    <name>A0A182PEQ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat-containing protein 92</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEQ4"/>
    <dbReference type="STRING" id="199890.A0A182PEQ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005409-RA">
        <property type="protein sequence ID" value="AEPI005409-PA"/>
        <property type="gene ID" value="AEPI005409"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005409"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005409-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40445" checksum="0720961B2A1B4396" modified="2016-09-07" version="1">MDSVQMISHIEQSLNYSVYDVKWIPCSAKFVSIGSKPKGTGVVQIYELNRGALDLVQEVEKEKSLKCSSFGASKLRTEHLAVGDFAGKLAVYDLERLDAPPVYEVNAHDGIINTLDAIGGSTVNCGAPEIVTGGRDGSVKVWDPRQPNDPVANISPASKDPAARRDCWAVGFGDSHNPVERVVCSGYDNGDLKLVDLRNLKLRWEANVTNGICAVEFDRKDIRMNKLAVSTLEGGLYVYDMRTQHSQKGFASVKERTVGQSLGTNGVISGAKSTVWTVKHLPQNRDIFVTGGGSGNVRIWLYHYPENRSKELTDGEQQGVAGTLEMLHATTLSTQPVHTFDWSPDRQGLAVCGSFDQTVRVLITTNLNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEV0</accession>
    <name>A0A182PEV0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PEV0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005455-RA">
        <property type="protein sequence ID" value="AEPI005455-PA"/>
        <property type="gene ID" value="AEPI005455"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005455"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003341">
        <property type="entry name" value="AGAP010418-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000017">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000845">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057855">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040379">
        <property type="entry name" value="WDR19/dyf-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039468">
        <property type="entry name" value="WDR19_WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920">
        <property type="entry name" value="OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920:SF0">
        <property type="entry name" value="WD REPEAT DOMAIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23389">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15911">
        <property type="entry name" value="Beta-prop_WDR19_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR19 first beta-propeller" evidence="4">
        <location>
            <begin position="19"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="WDR19 WD40 repeat" evidence="3">
        <location>
            <begin position="362"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="WDR19 WD40 repeat" evidence="3">
        <location>
            <begin position="460"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005455-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1293" mass="144253" checksum="DE3D938462D03680" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEZ6</accession>
    <name>A0A182PEZ6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microtubule-associated protein futsch</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEZ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005501-RA">
        <property type="protein sequence ID" value="AEPI005501-PA"/>
        <property type="gene ID" value="AEPI005501"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005501"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="912"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005501-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="989" mass="109505" checksum="753A276980825B96" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFC8</accession>
    <name>A0A182PFC8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PFC8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005634-RA">
        <property type="protein sequence ID" value="AEPI005634-PA"/>
        <property type="gene ID" value="AEPI005634"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005634"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029162">
        <property type="entry name" value="InaF-motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34929:SF1">
        <property type="entry name" value="INAF MOTIF CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34929">
        <property type="entry name" value="ZGC:153157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15018">
        <property type="entry name" value="InaF-motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005634-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="208" mass="23953" checksum="395E8B7BA0E8FF06" modified="2016-09-07" version="1">MSYTAEEKIKLAGEDSKDRLYEAKQNQKAIRILTVAAYVLCVSLVAIMLSLYYIFFWDPSTNPMQQKTQTIDTLIIPDHLAIRLANRSEVPASRFFHTFYQHLVQDRVVKIRKEVHISESSNLTRLIELYHQQQQYRQHRPDKQAHPGGADNAQLSYQVQSEQGADSDGPRLNADEDDGSDDYEQSGNYELYSNHTTIQLDADETEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGC3</accession>
    <name>A0A182PGC3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">General transcription and DNA repair factor IIH helicase/translocase subunit XPB</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA 3'-5' helicase/translocase XPB</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A182PGC3"/>
    <dbReference type="STRING" id="199890.A0A182PGC3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005982-RA">
        <property type="protein sequence ID" value="AEPI005982-PA"/>
        <property type="gene ID" value="AEPI005982"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005982"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="396"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="611"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="796"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005982-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="848" mass="95704" checksum="F5251CB8DF738927" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGG9</accession>
    <name>A0A182PGG9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2021-01" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGG9"/>
    <dbReference type="STRING" id="199890.A0A182PGG9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006028-RA">
        <property type="protein sequence ID" value="AEPI006028-PA"/>
        <property type="gene ID" value="AEPI006028"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006028"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000010">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="17">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006028-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="79" mass="8978" checksum="A49DE67A24AB99AA" modified="2016-09-07" version="1">MSRKEALSQFINQIHGRPVVVKLNSGVDYRGVLACLDGYMNIALDQTEEYVNGQLKNKYGDAFIRGNNVLYISTQKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHA9</accession>
    <name>A0A182PHA9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHA9"/>
    <dbReference type="STRING" id="199890.A0A182PHA9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006318-RA">
        <property type="protein sequence ID" value="AEPI006318-PA"/>
        <property type="gene ID" value="AEPI006318"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006318"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006318-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="837" mass="95840" checksum="1DEA9322935C194D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI36</accession>
    <name>A0A182PI36_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PI36"/>
    <dbReference type="STRING" id="199890.A0A182PI36"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006598-RA">
        <property type="protein sequence ID" value="AEPI006598-PA"/>
        <property type="gene ID" value="AEPI006598"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006598"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF34">
        <property type="entry name" value="LD40565P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="182"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006598-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="370" mass="41161" checksum="E547B1D002C3DE45" modified="2016-09-07" version="1">MRICIYEIKFPRVWCCAKCAASFLDKCITYIAENASECVKTNAFLNLTKEGLIQVISYDNLGLEEEDVWRCVLAWAKNQAGVTQPTAHWTEEERQRVCQYLAPVISHVRLFLIDSQVFAEEVEPTGAVPIELSLERYRRAALHFNKLPTAAASAAPVPAGPLTENDKRLQPRLMLNLFHGSAILKNDKIHFQGTLNGWFGAAKQTWRMVYRASTNGFAASAFHRHCDGVAPLFIIALSSNGAISGGFTDVAFAQTNRKGGYLHSEKAFLFALNYNNEPPTKFDIVKKPYAICYHPDCGPIFGAGADLLISNNCNVNMESYSNFPHSYDGPNATFGHLFGDYNFSIIDYEVFTLAPASAPAGNKLKHERYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIL7</accession>
    <name>A0A182PIL7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PIL7"/>
    <dbReference type="STRING" id="199890.A0A182PIL7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006779-RA">
        <property type="protein sequence ID" value="AEPI006779-PA"/>
        <property type="gene ID" value="AEPI006779"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006779"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013659">
        <property type="entry name" value="A_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006331">
        <property type="entry name" value="ADGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01431">
        <property type="entry name" value="adm_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08451">
        <property type="entry name" value="A_deaminase_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131316" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine/AMP deaminase N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="12">
        <location>
            <begin position="208"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine/AMP deaminase N-terminal" evidence="13">
        <location>
            <begin position="542"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="12">
        <location>
            <begin position="722"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006779-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1033" mass="119455" checksum="CAF877BDE2C31412" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIS1</accession>
    <name>A0A182PIS1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIS1"/>
    <dbReference type="STRING" id="199890.A0A182PIS1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006834-RA">
        <property type="protein sequence ID" value="AEPI006834-PA"/>
        <property type="gene ID" value="AEPI006834"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006834"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF86">
        <property type="entry name" value="CCP84AC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131330" evidence="4">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006834-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="138" mass="15386" checksum="EFE3270B0A9E7685" modified="2016-09-07" version="1">MNLFPATASIWLVAHLCVLLTAGEHLVEFVSNYQQNAEIDYSFRYYIDHPPSGVSLDHWENRKGDHVHGGYGVLEPGGFVRTVHYEVEGDSGFRTVIKTTAPGSSQQYNIHTGGRRTPPPQPLWNTKPVAFVQGVHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIX4</accession>
    <name>A0A182PIX4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin glycylase 3A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PIX4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006887-RA">
        <property type="protein sequence ID" value="AEPI006887-PA"/>
        <property type="gene ID" value="AEPI006887"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006887"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070736">
        <property type="term" value="F:protein-glycine ligase activity, initiating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000032">
        <property type="entry name" value="tubulin monoglycylase TTLL3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051437">
        <property type="entry name" value="TTLL_monoglycylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870:SF2">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="791"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1611"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1666"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="824"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1622"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1679"/>
            <end position="1697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006887-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1708" mass="194024" checksum="0094346C2C7E2DF1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ23</accession>
    <name>A0A182PJ23_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJ23"/>
    <dbReference type="STRING" id="199890.A0A182PJ23"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006937-RA">
        <property type="protein sequence ID" value="AEPI006937-PA"/>
        <property type="gene ID" value="AEPI006937"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006937"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14698">
        <property type="entry name" value="bZIP_CNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.880.10:FF:000004">
        <property type="entry name" value="Nuclear factor, erythroid 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047167">
        <property type="entry name" value="NFE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411:SF55">
        <property type="entry name" value="SEGMENTATION PROTEIN CAP'N'COLLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="437"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="536"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="462"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="643"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006937-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="677" mass="70122" checksum="F7F36DBB6656080E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJ44</accession>
    <name>A0A182PJ44_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Salivary secreted peptide</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJ44"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006958-RA">
        <property type="protein sequence ID" value="AEPI006958-PA"/>
        <property type="gene ID" value="AEPI006958"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006958"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131528" description="Salivary secreted peptide" evidence="1">
        <location>
            <begin position="33"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006958-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20882" checksum="5D6183EF21499A2F" modified="2016-09-07" version="1">MAFACESFFQKVVLTLVTLVVLLDLQTNGTFALRCHHCGWDTCGTHEELVECNLERVNQVHGNLQRLVSLPQYSELPNFGEFACFELRLTNSHGNRSGTVKSCTIQSSGMCSLTDWKSVKVTGCSTCDDRDFCNGFNTATVPAPVDKGTGFSFSLPQDAVAKSHKKRQGCPRSVDLRRRTIVWEISQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJW8</accession>
    <name>A0A182PJW8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Survival of motor neuron-related-splicing factor 30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Survival motor neuron domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in spliceosome assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Cajal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJW8"/>
    <dbReference type="STRING" id="199890.A0A182PJW8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007234-RA">
        <property type="protein sequence ID" value="AEPI007234-PA"/>
        <property type="gene ID" value="AEPI007234"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007234"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20399">
        <property type="entry name" value="Tudor_SPF30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010304">
        <property type="entry name" value="SMN_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681:SF26">
        <property type="entry name" value="SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681">
        <property type="entry name" value="SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06003">
        <property type="entry name" value="SMN_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Tudor" evidence="12">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007234-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="238" mass="27106" checksum="2FD0955489CC49E2" modified="2016-09-07" version="1">MADDLQNYKLQLQQVEAALLTDPDNAELLKLKEDLNEVIELTKDLIKAQQEPEQKKSAYIEPASSSYYDGVSGADKKQPKPAKVWKVGDKCSAKWIEDGQYYDATIESISETGEVSIVFEAYQNRSNTTISELKEPKTRNEVFPANSNKRMRHNQKEYLKKKKMKKIQRFKELEEERECEKNKWLQFTAKSSKKSGVKPKSIFASPENVNGRVGIGTCGVSGKPMTEFSHGEKYRKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK84</accession>
    <name>A0A182PK84_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PK84"/>
    <dbReference type="STRING" id="199890.A0A182PK84"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007350-RA">
        <property type="protein sequence ID" value="AEPI007350-PA"/>
        <property type="gene ID" value="AEPI007350"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007350"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131423" evidence="3">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="82"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007350-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="295" mass="33610" checksum="B6A89CF788110F56" modified="2016-09-07" version="1">MGVWGTYLLVSVLSLAATRVSAAQVGNPASQLTLLQQKLADLEATAQNLTQKIVQLRKEFLLIANQTDPNKEVENGTIPSYPDAPLWYRSCKEVPSNKSDKYLIRPTEKSEPFLAYCDQLSFGGGWLVFQLRYNGSVDFRRNWTEYRNGFGSVDGEFWLGLERLHRLTSAKPHELLVVMEDFTGNYEFALYSEFEIDNEMQHYSLKKLGTFIGSAGDSMRIHKGMKFSTSDRDNDRVSSLNCASSYEGAWWYDSCYQANLNGVYMNERNAKAIVWYTYKNATVGMAYSKMMIREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKL6</accession>
    <name>A0A182PKL6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
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        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
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            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="9">Epiroticus2</strain>
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                <person name="Howell P."/>
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                <person name="Arachchi H.M."/>
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                <person name="Gujja S."/>
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                <person name="Larimer J."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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            <strain evidence="4">Epiroticus2</strain>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2091"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2190"/>
            <end position="2209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007639-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2217" mass="242590" checksum="4F2A5CEFFBF4CD15" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL24</accession>
    <name>A0A182PL24_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PL24"/>
    <dbReference type="STRING" id="199890.A0A182PL24"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007641-RA">
        <property type="protein sequence ID" value="AEPI007641-PA"/>
        <property type="gene ID" value="AEPI007641"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007641"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000025">
        <property type="entry name" value="luciferin 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF353">
        <property type="entry name" value="GH16244P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="458"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007641-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="61675" checksum="C0005735BBD2706B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL30</accession>
    <name>A0A182PL30_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PL30"/>
    <dbReference type="STRING" id="199890.A0A182PL30"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007647-RA">
        <property type="protein sequence ID" value="AEPI007647-PA"/>
        <property type="gene ID" value="AEPI007647"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007647"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007647-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="100" mass="11683" checksum="EFF99B7F129C1FA4" modified="2016-09-07" version="1">MLTLRLPDTLSVSRSPAYTPPICFSTYTASSYRCRCSGCDSLFSSLMLLEHHKEEFEHWSDYEDDRRLPCCRRNRRDEDDYTDTESGSSEAESEDLERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL82</accession>
    <name>A0A182PL82_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CAS family C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CAS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PL82"/>
    <dbReference type="STRING" id="199890.A0A182PL82"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007699-RA">
        <property type="protein sequence ID" value="AEPI007699-PA"/>
        <property type="gene ID" value="AEPI007699"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007699"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11564">
        <property type="entry name" value="FAT-like_CAS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11549">
        <property type="entry name" value="Serine_rich_CAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.830:FF:000001">
        <property type="entry name" value="BCAR1 scaffold protein, Cas family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000001">
        <property type="entry name" value="Breast cancer anti-estrogen resistance 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.830">
        <property type="entry name" value="Serine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021901">
        <property type="entry name" value="CAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037362">
        <property type="entry name" value="CAS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014928">
        <property type="entry name" value="Serine_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038319">
        <property type="entry name" value="Serine_rich_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654">
        <property type="entry name" value="CAS SCAFFOLDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654:SF18">
        <property type="entry name" value="IP17195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12026">
        <property type="entry name" value="CAS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08824">
        <property type="entry name" value="Serine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Serine rich protein interaction" evidence="10">
        <location>
            <begin position="303"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="CAS family C-terminal" evidence="11">
        <location>
            <begin position="495"/>
            <end position="683"/>
        </location>
    </feature>
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            <begin position="67"/>
            <end position="155"/>
        </location>
    </feature>
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            <begin position="199"/>
            <end position="299"/>
        </location>
    </feature>
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            <begin position="464"/>
            <end position="501"/>
        </location>
    </feature>
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        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007699-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="74386" checksum="85F2F34FED673926" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMX2</accession>
    <name>A0A182PMX2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMX2"/>
    <dbReference type="STRING" id="199890.A0A182PMX2"/>
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        <property type="protein sequence ID" value="AEPI008296-PA"/>
        <property type="gene ID" value="AEPI008296"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008296"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="BTB_POZ_roadkill-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MATH_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Speckle-type POZ protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000008">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="8">
        <location>
            <begin position="177"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="346"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="626"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="674"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="806"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="518"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="770"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008296-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="861" mass="91580" checksum="E6A77B090D35F4A9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN73</accession>
    <name>A0A182PN73_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN73"/>
    <dbReference type="STRING" id="199890.A0A182PN73"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008397-RA">
        <property type="protein sequence ID" value="AEPI008397-PA"/>
        <property type="gene ID" value="AEPI008397"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008397"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131700" description="SCP domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="4">
        <location>
            <begin position="66"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="4">
        <location>
            <begin position="282"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008397-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="467" mass="51865" checksum="B87FE3AC8D09791F" modified="2016-09-07" version="1">MHQSTVALTLLLLSITIATDGYAPSYYCSPSLCPHGGPNVGCNPPPLSGGHFCYGKLPSVVPMTPAVQAHILHLHNYYRSRVASGYQFPLGPAAHMYTMVWDDELAAQAGNNARSCVFAHDRCRNTPQFLTSGQNLALLKYYEPGAYTVTELITRFIASWWKEWKYTKPAYIQAFPRSQLKNIGHFTMLVNDRTWKVGCAMQSWIEVGATKVYFVCNYSYNNIVTQEVYTVGRAGSQCQAGMNPSYPGLCRTGPNVGCNPPPPSGGSSCHGKSAIVVPMTSGFKATILHLHNYYRSQVASGNRAPLPSATGMYTLEWDDELAAQASNNARSCVFAHDRCRNTPQFRSSGQNVAIIKYHGLTYTVTGLIKSFLAGWWKEWKNTTPAYIQAFPHSQLYNIGHFTVLVNDRVRKVGCALQKWNEGRSIFVYFVCNYSYTNVINKKVYNVGRTGSDCKKGMNPNYFGLCMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNW0</accession>
    <name>A0A182PNW0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pro-resilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNW0"/>
    <dbReference type="STRING" id="199890.A0A182PNW0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008639-RA">
        <property type="protein sequence ID" value="AEPI008639-PA"/>
        <property type="gene ID" value="AEPI008639"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008639"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF85">
        <property type="entry name" value="PRO-RESILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008639-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32763" checksum="7142CCA368B5AA41" modified="2016-09-07" version="1">IKAEAPINSYLPPAHGHGHGGDGGHHEDHHTDLVPPSSSYGTPDSSYGPPHHQSGFHPDHHEHEDHHDHHDNHDDSGSFEDEPAKYEFSYEVDDEGADLSFGHEEMRDGDYTTGKYNVLLPDGRRQIVEYEADHKGYRPKITYEGGDEHPHHHEHPHEHGHEHGHGGYSKETPHNQLGYPRESHHDFEHNGIAHGSNEYDSHVHDNGHSRADHGIHDSHRGYDSNAHEYHGNGHGHGHNGHNGHNGHNGHNGHHHNGHNGHHRRRSSNSNSHHHPTNHQTNDHHHHNGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP05</accession>
    <name>A0A182PP05_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP05"/>
    <dbReference type="STRING" id="199890.A0A182PP05"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008684-RA">
        <property type="protein sequence ID" value="AEPI008684-PA"/>
        <property type="gene ID" value="AEPI008684"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008684"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="472"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008684-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="552" mass="63210" checksum="2E694D5640061446" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP92</accession>
    <name>A0A182PP92_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KANL3/Tex30 alpha/beta hydrolase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PP92"/>
    <dbReference type="STRING" id="199890.A0A182PP92"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008771-RA">
        <property type="protein sequence ID" value="AEPI008771-PA"/>
        <property type="gene ID" value="AEPI008771"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008771"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000147">
        <property type="entry name" value="uncharacterized protein LOC108093882 isoform X9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046879">
        <property type="entry name" value="KANL3/Tex30_Abhydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136:SF16">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="TESTIS DEVELOPMENT PROTEIN PRTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20408">
        <property type="entry name" value="Abhydrolase_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KANL3/Tex30 alpha/beta hydrolase-like" evidence="2">
        <location>
            <begin position="314"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008771-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="997" mass="107554" checksum="88430D2529BD13AB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPG6</accession>
    <name>A0A182PPG6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PPG6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008845-RA">
        <property type="protein sequence ID" value="AEPI008845-PA"/>
        <property type="gene ID" value="AEPI008845"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008845"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000093">
        <property type="entry name" value="CENP-meta, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="4"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="689"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1949"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="575"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="723"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="837"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1992"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="2129"/>
            <end position="2156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="2182"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008845-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2275" mass="260481" checksum="7B59E3DAC63DE916" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPT5</accession>
    <name>A0A182PPT5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPT5"/>
    <dbReference type="STRING" id="199890.A0A182PPT5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008965-RA">
        <property type="protein sequence ID" value="AEPI008965-PA"/>
        <property type="gene ID" value="AEPI008965"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008965"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098882">
        <property type="term" value="F:structural constituent of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019323">
        <property type="entry name" value="ELKS/CAST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861:SF0">
        <property type="entry name" value="BRUCHPILOT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861">
        <property type="entry name" value="ELKS/RAB6-INTERACTING/CAST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10174">
        <property type="entry name" value="Cast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="965"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="387"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="761"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1200"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="975"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008965-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1276" mass="148724" checksum="C740E62BCEF56A90" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ04</accession>
    <name>A0A182PQ04_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EnsemblMetazoa" id="AEPI009034-RA">
        <property type="protein sequence ID" value="AEPI009034-PA"/>
        <property type="gene ID" value="AEPI009034"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009034"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF18">
        <property type="entry name" value="PROTEIN TWEETY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="714"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="813"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="853"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1024"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="730"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="862"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="919"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1025"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1089"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1114"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1137"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1299"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1321"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009034-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1332" mass="148335" checksum="4B4F9A21D3B8CAE2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ42</accession>
    <name>A0A182PQ42_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. Cappuccino subfamily.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PQ42"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009072-RA">
        <property type="protein sequence ID" value="AEPI009072-PA"/>
        <property type="gene ID" value="AEPI009072"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009072"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920:SF7">
        <property type="entry name" value="FORMIN-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="911"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="933"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
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            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
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        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="861"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="935"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="954"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1373"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009072-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1402" mass="153472" checksum="0331CB9E253E0E6C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ67</accession>
    <name>A0A182PQ67_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PQ67"/>
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        <property type="gene ID" value="AEPI009097"/>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000724">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    <dbReference type="PANTHER" id="PTHR46591">
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR46591:SF1">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
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            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1496"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009097-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2225" mass="249751" checksum="3158055B829E9B92" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQC4</accession>
    <name>A0A182PQC4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylinositol 4-kinase beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:19878"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Rough endoplasmic reticulum membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PQC4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009154-RA">
        <property type="protein sequence ID" value="AEPI009154-PA"/>
        <property type="gene ID" value="AEPI009154"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009154"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000004">
        <property type="entry name" value="Phosphatidylinositol 4-kinase, catalytic, beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1141"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="410"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036767"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037860"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009154-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1424" mass="155942" checksum="E0FDB2D29FE9B3AF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQH8</accession>
    <name>A0A182PQH8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
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        </location>
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        <location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24817"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009209-PA"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1000" mass="110386" checksum="330020C9E93EEF4D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQW4</accession>
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            <fullName evidence="7">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L33, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQW4"/>
    <dbReference type="STRING" id="199890.A0A182PQW4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009345-RA">
        <property type="protein sequence ID" value="AEPI009345-PA"/>
        <property type="gene ID" value="AEPI009345"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009345"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.120:FF:000005">
        <property type="entry name" value="39S ribosomal protein L33, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009345-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="65" mass="7826" checksum="E34086E18B8EC782" modified="2016-09-07" version="1">MFITNILLKKAKSKNILVLMESAVSGHQFTMVRERLADKLELQRFDPYIQRMSLYRERKRLRSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR66</accession>
    <name>A0A182PR66_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PR66"/>
    <dbReference type="STRING" id="199890.A0A182PR66"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009448-RA">
        <property type="protein sequence ID" value="AEPI009448-PA"/>
        <property type="gene ID" value="AEPI009448"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009448"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903313">
        <property type="term" value="P:positive regulation of mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.230:FF:000001">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="14">
        <location>
            <begin position="100"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="12">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="12">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="12">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1039"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1056"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1089"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1123"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1152"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009448-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1161" mass="129391" checksum="9DF75BC8B92F6B62" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRX6</accession>
    <name>A0A182PRX6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRX6"/>
    <dbReference type="STRING" id="199890.A0A182PRX6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009711-RA">
        <property type="protein sequence ID" value="AEPI009711-PA"/>
        <property type="gene ID" value="AEPI009711"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009711"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009711-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="433" mass="48874" checksum="A081BE007DBD3EB6" modified="2016-09-07" version="1">MTLPTYNVFRPFAIFAGVFGIFQSLIWIGFAITGIIAYYCDIDFSGQTNTMGSLLTLTFFNVYFRGTCVQPNIPSIDMSLVQQLNLMPPGDVHAFVWVYLIIHLFWGISSLTLLTNARHKYVRYINVFLYIWIIITMIISVLDLALGILFAIDYDLIVNTLFEYPFGIGQVLPAVQVLATAAHVSGIMMVMAFRGWIFWIVNVSLAIFMFTQTFKIYDYNQMRRKQKQNGGTANGGYVPEGRDASRRPPIDAYDMSQPRTQSFAQPVVSEYRRPLERINEGPIPVESPVPPPQQDWSQQRTFEPKPTVVVSRTLEPLARPQSSEPEERPPVDNRPIPPPPPPKNFMNTVVRRDVAAAKVARELNYRNSFNVNNGNAGIAAVNLRPTGLNLTNPGPLNSDGDLPTPNYSPPMPRSNPFENRPPLRSVLRNSRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRX8</accession>
    <name>A0A182PRX8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRX8"/>
    <dbReference type="STRING" id="199890.A0A182PRX8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009713-RA">
        <property type="protein sequence ID" value="AEPI009713-PA"/>
        <property type="gene ID" value="AEPI009713"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009713"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="572"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="673"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009713-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="84550" checksum="3732AFD2EE1926B6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PT00</accession>
    <name>A0A182PT00_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribose-phosphate pyrophosphokinase 2</fullName>
            <ecNumber evidence="5">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphoribosyl pyrophosphate synthase II</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. The active form is probably a hexamer composed of 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PT00"/>
    <dbReference type="STRING" id="199890.A0A182PT00"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010086-RA">
        <property type="protein sequence ID" value="AEPI010086-PA"/>
        <property type="gene ID" value="AEPI010086"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010086"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000011">
        <property type="entry name" value="Putative ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="18">
        <location>
            <begin position="89"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003018"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00004996"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022727"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026067"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041814"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010086-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="403" mass="43331" checksum="F1BC4FFE85F740D3" modified="2016-09-07" version="1">MPVRSSHPIRARTLVRSNLEKASVISNANSNSNTSSGGSNLVHSLSSTTPSTGGSSISDSASDSKLPTDSVSVPSVDPHQLLQSRMPNIKVFSGSSHPDLASRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENIAEWRNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVASMVLVGDVKDRVAILVDDMADTCGTICHAADKLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMKDCPKIQCIDVSMMFAEAVRRTHNGESVSYLFSNVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTJ4</accession>
    <name>A0A182PTJ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="STRING" id="199890.A0A182PTJ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010280-RA">
        <property type="protein sequence ID" value="AEPI010280-PA"/>
        <property type="gene ID" value="AEPI010280"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010280"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056850">
        <property type="entry name" value="ARM_UBP34_24_USP9X_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055176">
        <property type="entry name" value="UBP24/USP9X/USP9Y_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF925">
        <property type="entry name" value="UBIQUITINYL HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25010">
        <property type="entry name" value="ARM_UBP24_USP9X-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22900">
        <property type="entry name" value="UCH_UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="1869"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="937"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1131"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1266"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1544"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2551"/>
            <end position="2588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2626"/>
            <end position="2688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="206"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="939"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1108"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1131"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1547"/>
            <end position="1559"/>
        </location>
    </feature>
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        <location>
            <begin position="1587"/>
            <end position="1624"/>
        </location>
    </feature>
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        <location>
            <begin position="2555"/>
            <end position="2566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2576"/>
            <end position="2586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2628"/>
            <end position="2643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2648"/>
            <end position="2670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010280-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2688" mass="302623" checksum="CE936062A2206B1B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTM0</accession>
    <name>A0A182PTM0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTM0"/>
    <dbReference type="STRING" id="199890.A0A182PTM0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010306-RA">
        <property type="protein sequence ID" value="AEPI010306-PA"/>
        <property type="gene ID" value="AEPI010306"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010306"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608:SF7">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="598"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="894"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="960"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010306-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1015" mass="109033" checksum="E83438EE88A99F52" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU51</accession>
    <name>A0A182PU51_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Selenoprotein T</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PU51"/>
    <dbReference type="STRING" id="199890.A0A182PU51"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010487-RA">
        <property type="protein sequence ID" value="AEPI010487-PA"/>
        <property type="gene ID" value="AEPI010487"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010487"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019389">
        <property type="entry name" value="Selenoprotein_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544">
        <property type="entry name" value="SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544:SF0">
        <property type="entry name" value="THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131774" description="Selenoprotein T" evidence="3">
        <location>
            <begin position="29"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010487-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32794" checksum="9DDF1C39E94FCA0C" modified="2016-09-07" version="1">MMRSLVRSHFKLLAAVLLAGLALSTVGAEKEIPLTKFSQDVGSYGATMTFLYCYSCGYRKAFDDYYNIIREKYPEITIRGGNYDPSGFNMLLSKVLLVTKLLLIAALMSNYDIGRYIGNPFAGWWRWCFNNKLYASMMIFFLGNTLEAQLISSGAFEITLNDVPVWSKLETGRFPAPQEMFQIIENHLQFANKLEPNPDFNICVFLNKLVLRCYNSFLIHPNHGHQDGGKYGGYGGGGGGAGGVGGGGGGGHNGYGTGLGVRPRRTRRNRAAELMHSRDGGELGSRGTAHYYYNHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUD2</accession>
    <name>A0A182PUD2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM135 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUD2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010568-RA">
        <property type="protein sequence ID" value="AEPI010568-PA"/>
        <property type="gene ID" value="AEPI010568"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010568"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010568-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="463" mass="52195" checksum="20D1621A1538A9E0" modified="2016-09-07" version="1">MQVLSKMTPVSVTCLEYVHPWTQSCTVATAELMIVGVQYCLRIYAAVYALSLVMRGRIPSLPELKKTLRGWLQSTAFLTTNAFSYSIFMCSIRRLMGSYNFYTASYVPALMAALVSIMVERSSRRALLALYVSNVATETGWNILQSRGLVKSIPHGEIAIFGLSTSVLMYCFRRNRQKEYRDSMFDVVRFAIGDSEVMKVDQQPAEEHAASSSRESNRRVSKSRKFPLPAIQAAVQAYLQLTERLKALGKHRLCRHRHGCVYETLSSGVRMFSIGLGIQVVMKAVLQMRKFISRPALLRKTFLSNEIARLGMFLGGFTSIYKMSSCLLRHFTDSDSPMFAFPSGLLASVAFAFYSDNTIALYIMWKTLQITYNWGIEKGYLPRVPGFTVMLYAVSTALLFHAATIEPKNLRPSYWKFLHSISGGRICIMDRSGFDVYGLDTSGQIRTMMNLCKTEPILQGQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUS7</accession>
    <name>A0A182PUS7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUS7"/>
    <dbReference type="STRING" id="199890.A0A182PUS7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010714-RA">
        <property type="protein sequence ID" value="AEPI010714-PA"/>
        <property type="gene ID" value="AEPI010714"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010714"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010714-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="632" mass="73046" checksum="C9D4355FBA4D7577" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUX9</accession>
    <name>A0A182PUX9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUX9"/>
    <dbReference type="STRING" id="199890.A0A182PUX9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010766-RA">
        <property type="protein sequence ID" value="AEPI010766-PA"/>
        <property type="gene ID" value="AEPI010766"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010766"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010766-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="202" mass="22060" checksum="3AA9F5419F5DC2C0" modified="2016-09-07" version="1">MEVAWRFRIIFVMAFVVIIFGDLLGYGGARKEPKDKSLLSGFTEVETNTANKMIPTGKETAASGAQARTSSSNDIGSDVEGDFDQDQDTSGLSAAELAARKEKLKNSLREACLPKLLCEMAAKPNYSLNVRERDLLSLIRSTTLSLTMAVSPTKWHFAAHMGQLLRDAGDALVTPIGCSHLWPSCPYSSKKLLKLTNVVHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVL7</accession>
    <name>A0A182PVL7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVL7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011004-RA">
        <property type="protein sequence ID" value="AEPI011004-PA"/>
        <property type="gene ID" value="AEPI011004"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011004"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011004-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="184" mass="20220" checksum="F9D5DBAEC39E2B67" modified="2016-09-07" version="1">MATAQTKSPLWKVLAAIVLLLVLYVADTASTSLVSSTRLRRVHKSTYSEAVSTDNNAAAAPAAVTGARTSSKGHLRDGHIGMMGRSIASKKTTLTTVKSTSTTLRQRVDQAVQMVRARSKEIKMEQEQKRVDRKLRRDQKKQEREQSSAPVAPINPHNLKMPDCPAGKVYNGRRCVAMGKMPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVS2</accession>
    <name>A0A182PVS2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fascin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fascin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVS2"/>
    <dbReference type="STRING" id="199890.A0A182PVS2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011059-RA">
        <property type="protein sequence ID" value="AEPI011059-PA"/>
        <property type="gene ID" value="AEPI011059"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011059"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23347">
        <property type="entry name" value="beta-trefoil_singed_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23351">
        <property type="entry name" value="beta-trefoil_singed_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23355">
        <property type="entry name" value="beta-trefoil_singed_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23359">
        <property type="entry name" value="beta-trefoil_singed_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000008">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000010">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000015">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000064">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010431">
        <property type="entry name" value="Fascin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022768">
        <property type="entry name" value="Fascin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024703">
        <property type="entry name" value="Fascin_metazoans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10551">
        <property type="entry name" value="FASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10551:SF9">
        <property type="entry name" value="FASCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06268">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005682">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fascin-like" evidence="7">
        <location>
            <begin position="34"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="7">
        <location>
            <begin position="155"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="7">
        <location>
            <begin position="283"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="7">
        <location>
            <begin position="417"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011059-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="511" mass="57385" checksum="94F06C342C70C0D8" modified="2016-09-07" version="1">MNGSGYEINTNGDILLQNQQKGWWTIGLINGQYKYMTAETFGYKLNANGASLKKKQLWTLEPSTTGDSIIYLKSHLGRYLSVDTFGNVLCESEERDAGSRFQISITDDNSGRWALKNEQRGYFLGGTPEKLTCTAKAPGKSELWSVHLAARPQVNLRSVGRKRFAHLSDTQDEIHVDANIPWGEDTLFTLEFRADEDGRYALHTCNNKYLNSNGKLENKCTDDCLFSAEYHSGHLALRDRHGLYLSPIGSKAVLKSRSQTVTRDELFSLEDSLPQASFIAALNSKYVSVKQGVDVTANQDEIGENETFQLEFDWSAHRWALRTTQDRYWCLSTGGGIQATGNRRSADALFELEWHGDGSVSFRANNGKLLATKRSGHLFATAEAIEETTKFYFYLINRPILVLKCEQGFVGYRAPGSNKLECNKAIYETILVERAQKGIVHFKGQNGKYWRVDGEGIAADSDVPCDGFFIELREPTRICLRSSDGRYLGATKNGTFKLVDTGYDTATQWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWP2</accession>
    <name>A0A182PWP2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWP2"/>
    <dbReference type="STRING" id="199890.A0A182PWP2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011379-RA">
        <property type="protein sequence ID" value="AEPI011379-PA"/>
        <property type="gene ID" value="AEPI011379"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011379"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011379-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="119" mass="14427" checksum="8D7B47C99D4967BA" modified="2016-09-07" version="1">MVRFIYKREQFFSALGEQYPELAINGESWNTLKEYEEAFRPFYIATKLMQTQHQPFSEFYMQWLNGIRELSKLKNNRFVSLLSNGLMHRLKLLKENQLFRAALYLDPRFNFLDSKEFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWP3</accession>
    <name>A0A182PWP3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWP3"/>
    <dbReference type="STRING" id="199890.A0A182PWP3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011380-RA">
        <property type="protein sequence ID" value="AEPI011380-PA"/>
        <property type="gene ID" value="AEPI011380"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011380"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009667">
        <property type="entry name" value="DUF1258"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06869">
        <property type="entry name" value="DUF1258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011380-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="69175" checksum="D4F5B4781DD664D3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX08</accession>
    <name>A0A182PX08_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PX08"/>
    <dbReference type="STRING" id="199890.A0A182PX08"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011495-RA">
        <property type="protein sequence ID" value="AEPI011495-PA"/>
        <property type="gene ID" value="AEPI011495"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011495"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000765">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="429"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011495-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="511" mass="55947" checksum="69ED1AB524D68ACF" modified="2016-09-07" version="1">MNVNKMTTAQKSAYLEAHMAVQQQMAQAAFQLQHHQHQLQQQHHSHSYTRTVKKPKINHDGHLFLHQGSLTQQSQQQHQEQCLIPPSALPNPTVSHYPSTIKVPQINAGSYTNEINASRDTVASAGTNTSSTNAASSTVTTTTGNASGNGSGGGSSGGCSSNSSGSSTFTVPDDVGMGFEGGVRVLQSLGNWYIVLSTTARLYLTTLSLLFLSHYALCFTHGFYHRMLLLGPRSPEIPPNIPRPNLIPFTEPYAEGGSMHPATRLKALQQVQQSSAAAVAAVAAAAVAVSGASHSKVPSAKGKTITAITNPTTTPKPVFECTVCGKGLARKDKLTIHMRIHTGEKPYVCEVCDRAFARRDKLVIHMNKFKHVTPTNIAPLGKRQNRSLTIEQEELKIEDNKPAIEVYHQALTPQTQTIVTNNIAAQPQQNQYEQQQQHQQQQKQLNNQLSHQYQQQVASNQRLQPALPDGTQLSGMSLQQSQHSLSWPCELCDRMFGSREDWTVHAKSHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYV3</accession>
    <name>A0A182PYV3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYV3"/>
    <dbReference type="STRING" id="199890.A0A182PYV3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015021-RA">
        <property type="protein sequence ID" value="AEPI015021-PA"/>
        <property type="gene ID" value="AEPI015021"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015021"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015021-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="510" mass="58255" checksum="E77F6B8D2C5A8E78" modified="2016-09-07" version="1">MALLGVLLLVAVLILSIVYLFLRSRHSYWPNRGFPYKPNPSLLFGQMQGNGTTRHAAYVTQEIYNYAKDRGERYMGYSFYFMPIVMVCDIELVKTVLVKDFTVFHDRGMYSNPTVDPLSGNLFSLEGHEWRALRHKLTPTFTSGRMKQMFGTMLQVAMELERRLLDHIDQELEMKDVLARFTTDVIGTCAFGIECNTLKNPDSDFLKYGKRVFEHRLPAMVKMTFAMLFKERAKALGVKVTDDDLEAFFLNLVHETVEHRERNNVHRNDFLDLLLEIKNKGSLEEQQHDGKPVASDGPGLTMNELAAQVFIFFVAGFETSSTVMNFCLYELAKNPDVQDRLREELNRAIDGNGGELTYDTVMGNEYLGQVVNETLRKYPPLETVLRVTAEDYTIPGTAHVIPRQRGVQIPVYAIHHDPAYYPDPECFDPDRFSADQCKARTPYTFLPFGEGPRICIGMRFGLMQVRVGLVSMLRAFRFLPTTRTPDRVVFDPKTFILSPAGGNFLRVAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PL01</accession>
    <name>A0A240PL01_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A240PL01"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015301-RA">
        <property type="protein sequence ID" value="AEPI015301-PA"/>
        <property type="gene ID" value="AEPI015301"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015301"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015301-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="448" mass="50186" checksum="7FC50D01CE00A262" modified="2017-10-25" version="1">MTGNTGNAIELLVQQIEKGHHFSNRIPVRKIYIDEDPNKEQPIPCPRCLERNRQSMVRYLFLNLSEAIFKCEAADCMYPFRNFKFKNFEESTVYRYQLNSQNEFDTNFASNFSTECYSYYSSIDHVASVDFNLDFLSSDGATELQPQKALAAEPSSKAQPPPAAHENLSTCFDTRFIDDILQDLFPSTTNPMPKTCNETKTACSSTEITTIDLPPKADSVFTQPCGRKLEKCLKVFEKTSNRNEDDVFKKPRAPAESNSLVVEPISPTKLRIKKIGGSGTKMKSPTSKGNKLKKSNDNALLPGVASVGGLELKQARALVKNKKIKPLEFVSSLNTLLQDKNTNKPMVERQPLVRQSPNCAKVQKMLNFIQRSMKTSEEKESPVAVATPVSDNVGSCNSDYSNFNAPDPCTASHESVITENYLVINGSMQLIDNDVDDKHTYHRLHVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PNC3</accession>
    <name>A0A240PNC3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A240PNC3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015303-RA">
        <property type="protein sequence ID" value="AEPI015303-PA"/>
        <property type="gene ID" value="AEPI015303"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015303"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012534594" evidence="1">
        <location>
            <begin position="30"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015303-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="230" mass="25999" checksum="44351CA625AEF111" modified="2017-10-25" version="1">MYRVVSFISAGTVLLVLLSSATLPSSGRGDPFVALRTATVSRTFLCWAIKLSPTAYVTDADCVRSYRKHQIVMIYGDITPNRTVQERLGRKVAGLRQAACRHRVPSLMLVGDPDGTNRSVLHRSVRNFIASYGMLQTRHQRSMTCRECQVLAIRRTLPCPVTPGTTALLYTACLKQIDALEKGFAAKSRASWDTWVWKLRRKLKATLYANLERFGRERLEMLNFMTGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PPS2</accession>
    <name>A0A240PPS2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A240PPS2"/>
    <dbReference type="STRING" id="199890.A0A240PPS2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015319-RA">
        <property type="protein sequence ID" value="AEPI015319-PA"/>
        <property type="gene ID" value="AEPI015319"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015319"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11328">
        <property type="entry name" value="AmyAc_maltase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013280759" description="alpha-glucosidase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="41"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015319-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="609" mass="70640" checksum="242E0FDDDEA2046B" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWJ8</accession>
    <name>A0A3F2YWJ8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A3F2YWJ8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015442-RA">
        <property type="protein sequence ID" value="AEPI015442-PA"/>
        <property type="gene ID" value="AEPI015442"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015442"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
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</entry>
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            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Howell P."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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</entry>
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                <person name="Zeng Q."/>
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                <person name="Alvarado L."/>
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                <person name="Chapman S.B."/>
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                <person name="Larimer J."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
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        <property type="gene ID" value="AEPI000263"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI000263"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF209">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="161"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="1279"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="1679"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="2090"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="2469"/>
            <end position="2588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="956"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1240"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1978"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2446"/>
            <end position="2466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1240"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000263-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2769" mass="320032" checksum="FCA58EDA66CE66FA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0D2</accession>
    <name>A0A182P0D2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regucalcin</fullName>
            <ecNumber evidence="7">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A182P0D2"/>
    <dbReference type="STRING" id="199890.A0A182P0D2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000364-RA">
        <property type="protein sequence ID" value="AEPI000364-PA"/>
        <property type="gene ID" value="AEPI000364"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000364"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008367">
        <property type="entry name" value="Regucalcin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF66">
        <property type="entry name" value="MIP34848P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01791">
        <property type="entry name" value="REGUCALCIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="16"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000364-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="330" mass="35978" checksum="A20E2A1C64328138" modified="2016-09-07" version="1">MANVKVEVLPGPFLQLGEAPHWDSESQSLYYVCILSSTLHRYDWKENKTYSAKIEGSTYASFVIPVKGRKGEFVVGSGTRLLVVSWDGLTETATIVKVLTDLGEEEADHRFNDGKVDGQGRLYAGTMLAEDSRNHFEMDDGKLYRYDAGRGQMVPLKCKVHISNGLTWSARTGKFYYIDSFAFDIKEYTVDAEGNLGKKMVSFEALPALIVRICSTGGETVLIKLKDDEAATEFIADGMTSDAEGNLYVAVFAGSKIIKINPESAKIVQEIALPVAQVTSVAFGGPNLDVLFATTAAKELSVPQEPPAGAVFKITGLETRGVPMNELQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0R7</accession>
    <name>A0A182P0R7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Essential MCU regulator, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Single-pass membrane protein with aspartate-rich tail 1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SMDT1/EMRE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0R7"/>
    <dbReference type="STRING" id="199890.A0A182P0R7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000499-RA">
        <property type="protein sequence ID" value="AEPI000499-PA"/>
        <property type="gene ID" value="AEPI000499"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000499"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018782">
        <property type="entry name" value="MCU_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33904">
        <property type="entry name" value="ESSENTIAL MCU REGULATOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33904:SF1">
        <property type="entry name" value="ESSENTIAL MCU REGULATOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10161">
        <property type="entry name" value="DDDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000499-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="99" mass="10686" checksum="7C438E0DB2B4132A" modified="2016-09-07" version="1">MVLTRVFRAVGRSSLLEAGGASGAGQAQQQLARLPLRRKYTYRSGALKPMPEITPFGLFGVICTVIPGLLIGATISKNMANFLEENDLFVPSDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P141</accession>
    <name>A0A182P141_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P141"/>
    <dbReference type="STRING" id="199890.A0A182P141"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000623-RA">
        <property type="protein sequence ID" value="AEPI000623-PA"/>
        <property type="gene ID" value="AEPI000623"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000623"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37002">
        <property type="entry name" value="AGAP007005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37002:SF10">
        <property type="entry name" value="TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000623-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="379" mass="38377" checksum="658B40E7C2A8AACE" modified="2016-09-07" version="1">MTAPGAPPCLGLGSTVDLGRCSRRPCGRGGSTPHGLLYPEFQHRPPPPSYQASMQEYRLRLLLLDRDRQSGRMRSTASPPPTYRSNVGSLLRIPLSSRYNNGSSNSIFGGISGIISGAVGGGSSNSVNNVVAAPPPAVPSGHADLLQVSSSPNPYGSDGHSTLPPSYRSVHLQPASEPLQQSARSVPVESNPAGSTVEDAAKNLISDANTQQSAPVGPPNRTAGVNHHAPSIIKIDDRCAPAERNSIPSVVSLIDTVMGDGKEQPSQDAGTDGGNVNSRLCAAGTVPTATAAGGKDLVTIVTISGTVEPSATGASRSVYTSGMNSVNSTQQQAGGGGGATCTLLNTNSTPLLATVIPVSKSTATATTSTAASVGGSEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1T8</accession>
    <name>A0A182P1T8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1T8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000872-RA">
        <property type="protein sequence ID" value="AEPI000872-PA"/>
        <property type="gene ID" value="AEPI000872"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000872"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000872-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="160" mass="17294" checksum="7FB6366D487FA4DF" modified="2016-09-07" version="1">MKQPMSKTQRLKNIFAKRMLRGGSGQPEENIAPTTTPDVAAVDEQDTKPTQGSGKLAKDDQMLVYAELELKPAGGEISFVNKPAASNEPTEYAEILYVQQQAGTTAGSEAAQQPEQQQQPQQPHQVQRHHSSEDNRPVIDVSLQKPSTKSEGGKTASGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P275</accession>
    <name>A0A182P275_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P275"/>
    <dbReference type="STRING" id="199890.A0A182P275"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001009-RA">
        <property type="protein sequence ID" value="AEPI001009-PA"/>
        <property type="gene ID" value="AEPI001009"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001009"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034128963" evidence="7">
        <location>
            <begin position="23"/>
            <end position="482"/>
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    </feature>
    <feature type="domain" description="Clip" evidence="9">
        <location>
            <begin position="246"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="276"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001009-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="482" mass="51245" checksum="145194DD4AF8F227" modified="2016-09-07" version="1">MSLDEICWKLLMFPWLVKLAHWKGICLNHMKTTTPFPFITLPPNFTFPASTVSATIPFTPLTSPSITFSTGPPLTSTTFPTASPSVPLTFSTSIETQTIPVSTLTSTTFNTQVPTSTAGGLTFPPSTITNPVLTFTPSTPLFPTVTFTNPSTGSTLPGAILTSTLPPVTPITGISPLPTFPTFLSTINPPGLTSTIPTTITLTTVSCPSITPTCPPSVLTSTTFSGFDPMPSIDPRQTYNGCPYDSCLTPNAQTGICIVYVNCDFILQLLIRNAYLRDPSIENFVTQSVCGYSDLTPMVCCPTFRFANQDSNTTASFTSPPTVTSAPGSFFFASIASAGAGSTSASPGTVTPSSGSSVRLPTNDADRCGMSNATHTRVVGGVDAQLNAWPWMAALGYRSSSFELNAGPRFLCGGTLITTQHVLTVAHCIQTALYFLSTNGQYYYYTLIGLISYGYECARAGFPGVYVKVTAYLPWIEANLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2E1</accession>
    <name>A0A182P2E1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heat shock protein 83</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2E1"/>
    <dbReference type="STRING" id="199890.A0A182P2E1"/>
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        <property type="protein sequence ID" value="AEPI001075-PA"/>
        <property type="gene ID" value="AEPI001075"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001075"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000003">
        <property type="entry name" value="endoplasmin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000003">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000003">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130703" description="Heat shock protein 83" evidence="12">
        <location>
            <begin position="23"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="13">
        <location>
            <begin position="98"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="294"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="758"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="783"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="197"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001075-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="799" mass="91537" checksum="61DD791B24DD9DA1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2G5</accession>
    <name>A0A182P2G5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mpv17-like protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2G5"/>
    <dbReference type="STRING" id="199890.A0A182P2G5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001099-RA">
        <property type="protein sequence ID" value="AEPI001099-PA"/>
        <property type="gene ID" value="AEPI001099"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001099"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF8">
        <property type="entry name" value="MPV17-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001099-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22785" checksum="77365301167ECE97" modified="2016-09-07" version="1">MIALVKWFRTATKTAFSKKYLLFTNVAISVSLSGVGDIIEQHYEIYNGELAAWDRQRTRFMSISGMTVGVFCHGWYNFMDRRFPGRTIGLVLKKVLIDQTVASPIVIFLFFATLSVLKRATWEETRREIREKFIRLYTAEWIVWPPAQIVNFYFLPTKYRVLYDNTISLGYDVYTSYVINDEIGGNSEDKTNAQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3W3</accession>
    <name>A0A182P3W3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FMC1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3W3"/>
    <dbReference type="STRING" id="199890.A0A182P3W3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001599-RA">
        <property type="protein sequence ID" value="AEPI001599-PA"/>
        <property type="gene ID" value="AEPI001599"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001599"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037667">
        <property type="entry name" value="FMC1_homologue"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31716">
        <property type="entry name" value="PROTEIN FMC1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31716:SF1">
        <property type="entry name" value="PROTEIN FMC1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001599-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="109" mass="12412" checksum="681D1B8EB0FC4CA4" modified="2016-09-07" version="1">MATAVRSAAGSSTLKQLLSELKAVRSSEGSGAYALASKYITDQYRRFETTEQQHCRAKEELQFTAQTYRCYLESLRKLKDLNENYRGKGERSIRETADMVGFKLPHDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P490</accession>
    <name>A0A182P490_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Envelope protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P490"/>
    <dbReference type="STRING" id="199890.A0A182P490"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001726-RA">
        <property type="protein sequence ID" value="AEPI001726-PA"/>
        <property type="gene ID" value="AEPI001726"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001726"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022048">
        <property type="entry name" value="Envelope_fusion-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12259">
        <property type="entry name" value="Baculo_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130802" description="Envelope protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001726-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="66945" checksum="73C2460024F18273" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4Z4</accession>
    <name>A0A182P4Z4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
            <ecNumber evidence="11">7.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.1.3" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182P4Z4"/>
    <dbReference type="STRING" id="199890.A0A182P4Z4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001981-RA">
        <property type="protein sequence ID" value="AEPI001981-PA"/>
        <property type="gene ID" value="AEPI001981"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001981"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140571">
        <property type="term" value="F:transmembrane ascorbate ferrireductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="14">
        <location>
            <begin position="107"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001981-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="321" mass="35354" checksum="9251FC6623680A5A" modified="2016-09-07" version="1">MNTVVKDVDGIAAVPREIRQTRPINASYQNGARHANSMGGEDAEGTGAEHEQLFADYRDDDDGDERKGSIEETAASTNTGEVMGRGNRNSNRNVNNRAIDRNPTFSGKLLLANALINVLMFGVAGYITYHCFNKAMVLFSWHPTFMSIGYLILMSQAVLTMSGANYFTHRYHHRTKVFLHWLLQAFAGVLISIAAVCIFLNKIRLGKPHFQTLHGIFGLVTVCLTLASIAGGVTTKYAFQLRHYMRPIYSKLGHGIVGTVAYLLGTATIGLGVYSRWFQEDNDANVRLTLVIAIGTIALYVIVAPVANTVQRIRTAVRTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P511</accession>
    <name>A0A182P511_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P511"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001998-RA">
        <property type="protein sequence ID" value="AEPI001998-PA"/>
        <property type="gene ID" value="AEPI001998"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001998"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001998-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="252" mass="26856" checksum="74F5616FD6C02780" modified="2016-09-07" version="1">MAANRKYYSSKEDIPREGDEGGGNDGGGGGGGGGPTTDPHKTGRDEVDHVLTASKTNGSQAIGAKKSPEDAGPKATGVTLDKFNIFHLRRRPKSDPGNGPIAKHAQQMAPSANGPPAAPGADETLKKKKSRFVKSASIARIFGNTYNTKKYDDSSALLKLQQFKRSFLNSEKFHKKDGGAGAAEEPEEGELQIGDACYVNDSESSAKAIKSITRGLGRLLRRNCHSIDISRPDPEYKVSYLGNVLTGWAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5H4</accession>
    <name>A0A182P5H4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5H4"/>
    <dbReference type="STRING" id="199890.A0A182P5H4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002164-RA">
        <property type="protein sequence ID" value="AEPI002164-PA"/>
        <property type="gene ID" value="AEPI002164"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002164"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10454">
        <property type="entry name" value="GIY-YIG_COG3680_Meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12934">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034998">
        <property type="entry name" value="ANKLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46427">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46427:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22945">
        <property type="entry name" value="LEM-3_GIY-YIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00540">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="LEM" evidence="2">
        <location>
            <begin position="470"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002164-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="791" mass="90198" checksum="8428B52FC837C9B9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5S7</accession>
    <name>A0A182P5S7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase subunit S1/VOA1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vacuolar ATPase subunit S1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5S7"/>
    <dbReference type="STRING" id="199890.A0A182P5S7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002268-RA">
        <property type="protein sequence ID" value="AEPI002268-PA"/>
        <property type="gene ID" value="AEPI002268"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002268"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033176">
        <property type="term" value="C:proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030641">
        <property type="term" value="P:regulation of cellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008388">
        <property type="entry name" value="Ac45_acc_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471:SF7">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131000" description="V-type proton ATPase subunit S1/VOA1 transmembrane domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="8">
        <location>
            <begin position="337"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002268-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="387" mass="42966" checksum="D5B90DD0C99CE530" modified="2016-09-07" version="1">MAKLGVTVALFLAVTVFGGAARASSVPVFVWGKPSVTYVPALSRYTSSEFAALVEAQIDEKTFTIVFAEDRLSAENLSQCKLKTQTCFKNLQKLERKSYLPSVEEPLSVLEGSNAQSVQLRADGTLSERIVPQAGGIVIVNLSGDDFASHDALIDALYGRLHKEYPNMVAIYTGKTPSFSYSSLVRKTRQAEPEPVKETLMIDGFLMVYEKFMFGQADAAELTVAKLTQATKVENTTSEAMQIQLTGAGAQVDLFFLLTQGSWEITGVRFDNQDYYLRHRVHVNQHFSYSCNQWEYYSTDLQKKIVFEEVQLQPFWPGADGTPPVSNRFGDAWYCVGFTTGGILSGLFLVLIFIIIGSYGIAWMMDIRTMDRFDDPKGKTITVSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5T9</accession>
    <name>A0A182P5T9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5T9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002280-RA">
        <property type="protein sequence ID" value="AEPI002280-PA"/>
        <property type="gene ID" value="AEPI002280"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002280"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002280-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="646" mass="73355" checksum="EBF1DC93432359C1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P643</accession>
    <name>A0A182P643_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U2 snRNP auxiliary factor large subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with the U2AF small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P643"/>
    <dbReference type="STRING" id="199890.A0A182P643"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002391-RA">
        <property type="protein sequence ID" value="AEPI002391-PA"/>
        <property type="gene ID" value="AEPI002391"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002391"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130859" description="U2 snRNP auxiliary factor large subunit" evidence="12">
        <location>
            <begin position="18"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="408"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="522"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="650"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="269"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="315"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002391-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="748" mass="81079" checksum="1A6A4E68C66B705E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P664</accession>
    <name>A0A182P664_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P664"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002412-RA">
        <property type="protein sequence ID" value="AEPI002412-PA"/>
        <property type="gene ID" value="AEPI002412"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002412"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="890"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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            <end position="1087"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1088"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1121"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1215"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1370"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1478"/>
            <end position="1510"/>
        </location>
    </feature>
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            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002412-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1624" mass="185486" checksum="9D51DDC0B5625C20" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6B7</accession>
    <name>A0A182P6B7_9DIPT</name>
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        <recommendedName>
            <fullName evidence="14">Actin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6B7"/>
    <dbReference type="SMR" id="A0A182P6B7"/>
    <dbReference type="STRING" id="199890.A0A182P6B7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002465-RA">
        <property type="protein sequence ID" value="AEPI002465-PA"/>
        <property type="gene ID" value="AEPI002465"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002465"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002465-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41777" checksum="B5D215C675D7A119" modified="2016-09-07" version="1">MCDDDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETVYNSIMKCDVDIRKDLYANTVMSGGTTMYPGIADRMQKEITALAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6R0</accession>
    <name>A0A182P6R0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6R0"/>
    <dbReference type="STRING" id="199890.A0A182P6R0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002608-RA">
        <property type="protein sequence ID" value="AEPI002608-PA"/>
        <property type="gene ID" value="AEPI002608"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002608"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002608-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="147" mass="15684" checksum="987B82AB2B4A2A69" modified="2016-09-07" version="1">MQRLSPKFAPPIEFVDQATLSPPEGYKDGSGLLDNALGGALGGHVFGAQHIQQLQVIQRLQQQRAAMLAARAAAGQQGQQTGTAGQGQAGSQTVSASQQQQQQQQQQQQQQAQQAAVCTECAECAECAAKQMHDEVSKNQNKNPIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6R3</accession>
    <name>A0A182P6R3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6R3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002611-RA">
        <property type="protein sequence ID" value="AEPI002611-PA"/>
        <property type="gene ID" value="AEPI002611"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002611"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130880" evidence="2">
        <location>
            <begin position="25"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002611-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="921" mass="101729" checksum="4082394B1E617C63" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6W8</accession>
    <name>A0A182P6W8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">(Mt)TrpRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="STRING" id="199890.A0A182P6W8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002668-RA">
        <property type="protein sequence ID" value="AEPI002668-PA"/>
        <property type="gene ID" value="AEPI002668"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002668"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052267">
        <property type="entry name" value="N-DRC_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14690">
        <property type="entry name" value="IQ MOTIF CONTAINING WITH AAA DOMAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14690:SF0">
        <property type="entry name" value="IQ MOTIF CONTAINING WITH AAA DOMAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="15">
        <location>
            <begin position="1041"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="806"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="939"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="939"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002668-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1301" mass="149515" checksum="BF66D649407BC8EE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P722</accession>
    <name>A0A182P722_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P722"/>
    <dbReference type="STRING" id="199890.A0A182P722"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002724-RA">
        <property type="protein sequence ID" value="AEPI002724-PA"/>
        <property type="gene ID" value="AEPI002724"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002724"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130993" description="Phenoloxidase-activating factor 2" evidence="10">
        <location>
            <begin position="21"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="201"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002724-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="433" mass="48274" checksum="951EBD7CDCA9B082" modified="2016-09-07" version="1">MTLALKGAVLLILFVSTVYALSIVRDRDENEQLLNLNDIDQTLVEEDHGVAGVGIPKVHRLNFAERKQLRQSKHLDQNELSRKRRATEGSGSTPSKGKECKTRAGEKGHCTRYQNCKGPELKDSVWSILQHLCVIEGISVGVCCPDVIQDGNGPEFSVRLPALADSYDDVDGLGDGPTGRDAIVRPEERGCGLSTKQLSKIAGGRPADSNEWPWMVALVMSRASFCGGVLITDRHVLTAAHCVMNLKLNQFVVRLGEYDFKQFNETRYRDFRVAEIRAHADFDQISYENDIAMLKLVQPSFFNSYIWPICMPPLDDAWTGYQAVVTGWGTQFFGGPHSPVLMEVRIPIWSNQECQEVYVNRIYNTTLCAGEYDGGKDSCQGDSGGPLMIQLPNRRWAVVGIVSWGIRCGEANHPGIYTRVSSYVRWIIENAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7I4</accession>
    <name>A0A182P7I4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Enoyl-[acyl-carrier-protein] reductase, mitochondrial</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">2-enoyl thioester reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182P7I4"/>
    <dbReference type="STRING" id="199890.A0A182P7I4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002886-RA">
        <property type="protein sequence ID" value="AEPI002886-PA"/>
        <property type="gene ID" value="AEPI002886"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002886"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000010">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="15">
        <location>
            <begin position="40"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002886-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="363" mass="39447" checksum="9E945EF091EBC2A2" modified="2016-09-07" version="1">MAQMVRQLWNVPSATHPFLAARHMSVMAKVLRYGEFGEPGKVLQLQEEPVPDPKQGEVLIKTLGAPINPADINTIQGKYPVKPAFPAVGGNECVGEVLAIGGNGSGSGSLKVGDRVVPFSTGLGTWRSHAIYGANQLMKVPASIGVAEAATITVNPCTGYRMLKDFVALKPGDTVIQNGANSACGQAIIQLCRAWNVECVGIVRDRPEFAQLKDYLKGLGAAEILTEEELRTTKLFKDGIFRKPKLALNCVGGKNALELSRQLDQAGVMVTYGGMSREPVTVPTASLIFKDLRFVGFWMTRWTKENAGSVLRSEMFNELFGLIDRGALKAPAHEMIPFEDYKTAVTNALNIQGFVGKKYIFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7Y6</accession>
    <name>A0A182P7Y6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7Y6"/>
    <dbReference type="STRING" id="199890.A0A182P7Y6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003039-RA">
        <property type="protein sequence ID" value="AEPI003039-PA"/>
        <property type="gene ID" value="AEPI003039"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003039"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003039-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="100" mass="11194" checksum="CA58BB1CC099A088" modified="2016-09-07" version="1">MQAHDGPKRSYRHDHQQHQRAPEPEVSRRVTFCSGLVLQAKLVPARAAIWLWVLCVCSFAIAPARAGPRYSSRIVETKSGAIRGVILELNSKHLEPVEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8V7</accession>
    <name>A0A182P8V7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transmembrane protein 43 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM43 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8V7"/>
    <dbReference type="STRING" id="199890.A0A182P8V7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003361-RA">
        <property type="protein sequence ID" value="AEPI003361-PA"/>
        <property type="gene ID" value="AEPI003361"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003361"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012430">
        <property type="entry name" value="TMEM43_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13416">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13416:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07787">
        <property type="entry name" value="TMEM43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003361-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42915" checksum="8F3CBC4A5DBCF02B" modified="2016-09-07" version="1">MRLSEAIKSRWVTTLFGTVLLLAGSVVLIWNEGRTIRILLSLEEALNDAVTVSADAPYEKQYEGRLIHLNGALSTGEPLTEPDYNIQVQAVKLKRRVQMYQWVEESVETRFGESVATVETEERTYFYSREWRDQLVDSRSFYIRSGHHNPTSFPIDSTVHVSEHVHVGPYELGAVAKDRFRTFQEVTSDTRPEDPSVRMHSGLYYHCNDIWNPEIGDIRIQFAYAGLEGSYVTVVGKLEGGKIVPYESTHFRKVLLLEPGEHSLSEIFRFEHQQQRMTTWGIRFIGWALLFFATICTATIMQHLAREHRLLRMFLPDTNSTLSTNVMMSFSLALVIVSIAWIVHRPWLGGGLLFAAMSPLLYCARGIMGSYQRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8W1</accession>
    <name>A0A182P8W1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein THEM6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THEM6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8W1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003365-RA">
        <property type="protein sequence ID" value="AEPI003365-PA"/>
        <property type="gene ID" value="AEPI003365"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003365"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003365-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="760" mass="81995" checksum="EFB8E5E5C307385D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9L7</accession>
    <name>A0A182P9L7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">E3 ubiquitin-protein ligase trim33</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9L7"/>
    <dbReference type="STRING" id="199890.A0A182P9L7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003622-RA">
        <property type="protein sequence ID" value="AEPI003622-PA"/>
        <property type="gene ID" value="AEPI003622"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003622"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19805">
        <property type="entry name" value="Bbox1_TIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19775">
        <property type="entry name" value="Bbox2_TIF1_C-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05502">
        <property type="entry name" value="Bromo_tif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15541">
        <property type="entry name" value="PHD_TIF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000074">
        <property type="entry name" value="Tripartite motif containing 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF304">
        <property type="entry name" value="BONUS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="15">
        <location>
            <begin position="130"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="15">
        <location>
            <begin position="192"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="1031"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1132"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="720"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="818"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="919"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="966"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="919"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1002"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003622-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1231" mass="130982" checksum="7346D643335072AD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9W9</accession>
    <name>A0A182P9W9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9W9"/>
    <dbReference type="STRING" id="199890.A0A182P9W9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003723-RA">
        <property type="protein sequence ID" value="AEPI003723-PA"/>
        <property type="gene ID" value="AEPI003723"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003723"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000082">
        <property type="entry name" value="protein MTO1 homolog, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="5">
        <location>
            <begin position="582"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003723-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="663" mass="73565" checksum="0BD2888C5FF695EE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9Y3</accession>
    <name>A0A182P9Y3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FXNA-like protease</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9Y3"/>
    <dbReference type="STRING" id="199890.A0A182P9Y3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003737-RA">
        <property type="protein sequence ID" value="AEPI003737-PA"/>
        <property type="gene ID" value="AEPI003737"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003737"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000008">
        <property type="entry name" value="Endoplasmic reticulum metallopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053973">
        <property type="entry name" value="ERMP1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053974">
        <property type="entry name" value="ERMP1_1-A_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF22">
        <property type="entry name" value="ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22249">
        <property type="entry name" value="ERMP1-TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22248">
        <property type="entry name" value="ERMP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="16">
        <location>
            <begin position="139"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1/1-A TM" evidence="18">
        <location>
            <begin position="412"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1-like C-terminal" evidence="17">
        <location>
            <begin position="636"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003737-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="868" mass="97644" checksum="C6E2D17C4B411B84" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAA6</accession>
    <name>A0A182PAA6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAA6"/>
    <dbReference type="STRING" id="199890.A0A182PAA6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003860-RA">
        <property type="protein sequence ID" value="AEPI003860-PA"/>
        <property type="gene ID" value="AEPI003860"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003860"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF257">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="230"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="409"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003860-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="628" mass="68546" checksum="EFADBDCF0B171BA7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBB0</accession>
    <name>A0A182PBB0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PBB0"/>
    <dbReference type="STRING" id="199890.A0A182PBB0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004215-RA">
        <property type="protein sequence ID" value="AEPI004215-PA"/>
        <property type="gene ID" value="AEPI004215"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004215"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF14">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="5">
        <location>
            <begin position="220"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="5">
        <location>
            <begin position="884"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="368"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="619"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004215-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="990" mass="110420" checksum="E7EAFADE55D1B298" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBD0</accession>
    <name>A0A182PBD0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBD0"/>
    <dbReference type="STRING" id="199890.A0A182PBD0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004235-RA">
        <property type="protein sequence ID" value="AEPI004235-PA"/>
        <property type="gene ID" value="AEPI004235"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004235"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007367">
        <property type="term" value="P:segment polarity determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000019">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000036">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000048">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0709">Segmentation polarity protein</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="477"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="537"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="229"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004235-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="738" mass="80923" checksum="11D2C3A0050EC388" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBJ1</accession>
    <name>A0A182PBJ1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBJ1"/>
    <dbReference type="STRING" id="199890.A0A182PBJ1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004296-RA">
        <property type="protein sequence ID" value="AEPI004296-PA"/>
        <property type="gene ID" value="AEPI004296"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004296"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000082">
        <property type="entry name" value="Leucine-rich repeat-containing 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF87">
        <property type="entry name" value="KEKKON 6, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131116" description="Ig-like domain-containing protein" evidence="9">
        <location>
            <begin position="31"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="274"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="760"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004296-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="814" mass="89452" checksum="E009835A81ED3863" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBL0</accession>
    <name>A0A182PBL0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translocator protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBL0"/>
    <dbReference type="STRING" id="199890.A0A182PBL0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004315-RA">
        <property type="protein sequence ID" value="AEPI004315-PA"/>
        <property type="gene ID" value="AEPI004315"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004315"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004315-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18939" checksum="B4B3965B12A041E4" modified="2016-09-07" version="1">MQNKGEIAKIVGAVVLPQLGGFVNGKLTRTQITEWYNHLNFPWFKPPNWLFAPVWTALYSGMGYASYLVWKTGGGFGGAAQLPLALYGTQLALNWAWTPIFFGYHQLKWVIAATGVAFYRINKLAGYLFIPYFAWCAFASLLNYNIYKLNTPPASTATIEEVTENPKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBZ6</accession>
    <name>A0A182PBZ6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBZ6"/>
    <dbReference type="STRING" id="199890.A0A182PBZ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004452-RA">
        <property type="protein sequence ID" value="AEPI004452-PA"/>
        <property type="gene ID" value="AEPI004452"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004452"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000077">
        <property type="entry name" value="Kirre like nephrin family adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="43"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="156"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="261"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="352"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="436"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="804"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="854"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="907"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004452-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="945" mass="100721" checksum="866C34818FC71F2E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC00</accession>
    <name>A0A182PC00_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Regulator of microtubule dynamics protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein FAM82B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC00"/>
    <dbReference type="STRING" id="199890.A0A182PC00"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004456-RA">
        <property type="protein sequence ID" value="AEPI004456-PA"/>
        <property type="gene ID" value="AEPI004456"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004456"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF16">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004456-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="436" mass="50132" checksum="D7832CEE4FFF78F3" modified="2016-09-07" version="1">MSAEELKLLDELFEKCQYEDSLDMIEKLTDRESCEVKWRLARTVFFLSKQSTVDQEKEKLVRQAFEHATAALEADGDNFGANKWYGAILSEKAALDGVTERIKQLENVQKHFQRAVSLNGTSDPGIWHMLGQFNYKLSEVNWITRKLINSVAPNPPTASYAEALECFTKAETIKPGFYALNLLYLGKCHLALKQSGEAKAWLERAASVEVRCEDDRICREEATELLKKLKHNTDPDYETLWRLCRVVYSITRELAVDEQKAKELEALIYEGFEYAKEALAQQPDASRSHKYYAIFLAEKTGIEGLKERVLQLSTILRHLRRATELDETDPFAWFVLGRFYHKLAGLAWFQKKMIHTFTSDIPEASYEDALRFFERAEQLQPNFFPLNHLMLGETYAALKKPKKARPFLELAANQTAPSTAEDREAQREAKALLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCB2</accession>
    <name>A0A182PCB2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCB2"/>
    <dbReference type="STRING" id="199890.A0A182PCB2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004567-RA">
        <property type="protein sequence ID" value="AEPI004567-PA"/>
        <property type="gene ID" value="AEPI004567"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004567"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051662">
        <property type="entry name" value="H2.0_Homeobox_NeuralPatt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24331">
        <property type="entry name" value="DBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24331:SF0">
        <property type="entry name" value="DBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="198"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004567-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="246" mass="27775" checksum="F5FC59DF52A90C35" modified="2016-09-07" version="1">MHLWPYIQQNLIQQNHLANPAFLGAHPHHPHHQQLPPHHHHHPHHHPHHHHHHHPQQPGAHPLSPHQQHLGPSGSPTGGHPANNGNGNTSSSNNGPHHLHNSSSNSTSESGSLPNSPELQDGPALQQQQQQQQRDNKIIAKPLPSRPTPFLHHSLNHPHLHSLLAHCRNPYMPGGPQVFPLPPGQGFPWAHSTRGKPRRGMMRRAVFSDSQRKGLEKRFQLQKYISKPDRKKLAERLGLKDSQRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEN6</accession>
    <name>A0A182PEN6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEN6"/>
    <dbReference type="STRING" id="199890.A0A182PEN6"/>
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        <property type="protein sequence ID" value="AEPI005391-PA"/>
        <property type="gene ID" value="AEPI005391"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF71">
        <property type="entry name" value="PROTEIN TRAPPED IN ENDODERM-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
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            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
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            <begin position="320"/>
            <end position="341"/>
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            <begin position="60"/>
            <end position="339"/>
        </location>
    </feature>
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            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
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            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005391-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="347" mass="38016" checksum="D271D3F93F6BA236" modified="2016-09-07" version="1">MGNDTIGNLSGWPAEEDGVFCSTEISIVAASSATFIAVLGTIGLFVVYLYPNYANGMLARNVTTLLALGRNRAVRQRRRQPTTAFVMSLATADLLFCVAVMPLMALRYSRRRWPFVSDSLWCRLFPVALYGTVATSVLSLVALTVNRYVLIVHPSWYGAVYRTPGMVPLQLAVCWAIPYGLMALPLFELWGRLGFDRRTFSCTVLPSITSIGTFSASPKKFIFIVGFALPFCAIVLCYTAIIGAVRRQRHNMQRYSAKPAVSTTSTPGSSTAGPSNDDDERHLTRTTAAIFGCFMLCFLPLTIANVLLEDAESAGEAGDVHVLASILTWHSAVLNPFIYALGSRHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PES4</accession>
    <name>A0A182PES4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PES4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005429-RA">
        <property type="protein sequence ID" value="AEPI005429-PA"/>
        <property type="gene ID" value="AEPI005429"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005429"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005429-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="155" mass="17610" checksum="CEB213854DD9639D" modified="2016-09-07" version="1">MLTNRAFRVLSYLFGSINILFVMVILSMGAEQLLVNWRTAISELIIPCTLNILFAMCWIIGAGLRRPTFIAMFKYFAYIQMALLAAVILYSAYYGYTKGLSSNLLNVMFLLTSLFFLSLMEVLIAIGTERAVAKERNLLRLMHSTGQEMSDWSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PES8</accession>
    <name>A0A182PES8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PES8"/>
    <dbReference type="STRING" id="199890.A0A182PES8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005433-RA">
        <property type="protein sequence ID" value="AEPI005433-PA"/>
        <property type="gene ID" value="AEPI005433"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005433"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01224">
        <property type="entry name" value="PH_Collybistin_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053086">
        <property type="entry name" value="RhoGEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45834:SF3">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45834">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="432"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="578"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="982"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1101"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1132"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005433-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1162" mass="127700" checksum="120B5063855EF96C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PET2</accession>
    <name>A0A182PET2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Jun subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PET2"/>
    <dbReference type="STRING" id="199890.A0A182PET2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005437-RA">
        <property type="protein sequence ID" value="AEPI005437-PA"/>
        <property type="gene ID" value="AEPI005437"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005437"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14696">
        <property type="entry name" value="bZIP_Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000012">
        <property type="entry name" value="Putative transcription factor AP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005643">
        <property type="entry name" value="JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03957">
        <property type="entry name" value="Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="238"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="243"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005437-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="314" mass="34321" checksum="1C1A4F266BF179BD" modified="2016-09-07" version="1">MRNNVLSSKHTNNNTMESFYEDANTQYIPATTNLVAVTTGSGNGLKRPATLELNLTPGKARKTRYNTSVTMPSVLPSPDLQMLKMVSPELEKIISTNAALPTPTPSAVMFPPSATSEQQQFVKGFEDALQSIHNKDTTSNNNNSSTSNNNNSSTNLIGGTATLDRLCPTTTIIAPTTAIVTATTNLASTVPTIGMSGGEITYTNLDYPGVVKEEPQPSTSTNHQTPPVSPIDMESQERIKLERKRLRNRVAASKCRRRKLERISKLEERVKELKAQNAELGGVVCNLKQHICQLKQQVIEHHRSGCTITLMGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEX4</accession>
    <name>A0A182PEX4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD finger protein rhinoceros</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May function as a negative regulator of the EGFR/Ras/MAPK signaling pathway during eye development.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the JADE family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PEX4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005479-RA">
        <property type="protein sequence ID" value="AEPI005479-PA"/>
        <property type="gene ID" value="AEPI005479"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005479"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15707">
        <property type="entry name" value="ePHD_RNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15573">
        <property type="entry name" value="PHD_JADE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000004">
        <property type="entry name" value="Jade family PHD finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000030">
        <property type="entry name" value="Protein Jade-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF160">
        <property type="entry name" value="PHD FINGER PROTEIN RHINOCEROS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="269"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="321"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="437"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="699"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1177"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1269"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1937"/>
            <end position="2002"/>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005506-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="344" mass="38332" checksum="4DE37F00BAD44641" modified="2016-09-07" version="1">MLASEHPCRVCLAEGARNIFSTSTINDETCTVASINHIRHKLQYVTQLQVNENDGLPFWICELCVVQLNIAYRFKLLAGESDRSLRQRLESREASTDIPNALTLNETVPSHDGKLPAVKQEPLNAARNTDLCESPLLVSGQSWNAANLTNSSASDTNHAPAMVCLQRDLINPAEDEAYLKEIVDMKVIAIPWEIICDSASNDRQPSTSSASNSPKQSVRQDTPADSPAPGSPKTQAKKRKRSGLDRRRSASSTKDRSKRRRETETTADAGDTMGTPKENLKPPSKAALRKRRLQKLVESLRIDMMDDKLMNRYKLTQDVPTASNPKVPMKRRNSICVSSFTEWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFC3</accession>
    <name>A0A182PFC3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PFC3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005629-RA">
        <property type="protein sequence ID" value="AEPI005629-PA"/>
        <property type="gene ID" value="AEPI005629"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005629"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005629-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="93" mass="10609" checksum="92DFA1B0D7BD63F2" modified="2016-09-07" version="1">MSSLPAFLQVSLKSPGKREEDADSRGKMGSSEEVRFWFREREGGFRRRQRRLKAMVLLGKREQPLDTDGVSRRPARREHKPNVAFGGSVAEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFE2</accession>
    <name>A0A182PFE2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PFE2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005648-RA">
        <property type="protein sequence ID" value="AEPI005648-PA"/>
        <property type="gene ID" value="AEPI005648"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005648"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005648-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="392" mass="38780" checksum="35DCDB0792F6C48F" modified="2016-09-07" version="1">MLSYMLPVEEKAPSAAAAAATRNLSLNLTATTTAAATGGAVSSGSAASVTVPRDTSAPGSGASSAAPSTSAQVRSIIKPTIKHGGGGSVASHRYQLIGSGGADTKLLSDSSAAGGGAGAGPAAGAGRSNRDRWQDEPEADQCDESTNLLAGGGADDEDEDEREGLEDERSRRRGTQRAGAVKSDKNFNNLIVVTNGRHAKPTNGNHAGPPAKLASVLKPTNGAGPTGRPGSSNGGAIAGNTGAYYNGYIAVSGDNDDEHHRLLVSANNLRNASVEPGQEWGPEEPAPTDPPRPVASTFSSTSRTNGNTCRTMNSLNGNLMGADPPSVAPLPLESVDGGGGEGGAAGGAADVSFGSDSDSATGAGGSGSTATGGGKKVKLNKLGGNKNVTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFI4</accession>
    <name>A0A182PFI4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase APD1-4 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PFI4"/>
    <dbReference type="STRING" id="199890.A0A182PFI4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005691-RA">
        <property type="protein sequence ID" value="AEPI005691-PA"/>
        <property type="gene ID" value="AEPI005691"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005691"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032010">
        <property type="entry name" value="APD1-4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032008">
        <property type="entry name" value="APD1-4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39077">
        <property type="entry name" value="DUF4793 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39077:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE APD1-4 MIDDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16041">
        <property type="entry name" value="APD1-4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16040">
        <property type="entry name" value="APD1-4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase APD1-4 N-terminal" evidence="3">
        <location>
            <begin position="70"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase APD1-4 middle" evidence="4">
        <location>
            <begin position="439"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005691-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="61975" checksum="E7EF039309FACAB9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFQ2</accession>
    <name>A0A182PFQ2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centaurin-gamma-1A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
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                <person name="Saif S."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Epiroticus2</strain>
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            <strain evidence="2">Epiroticus2</strain>
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</entry>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Allen A.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="150"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="205"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="577"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="717"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="915"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="973"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1054"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="976"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="989"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1073"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1183"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005907-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1291" mass="146870" checksum="2071682D3119F7AF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGI0</accession>
    <name>A0A182PGI0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGI0"/>
    <dbReference type="STRING" id="199890.A0A182PGI0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006039-RA">
        <property type="protein sequence ID" value="AEPI006039-PA"/>
        <property type="gene ID" value="AEPI006039"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006039"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039871">
        <property type="entry name" value="FAM8A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13659">
        <property type="entry name" value="AUTOSOMAL HIGHLY CONSERVED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13659:SF5">
        <property type="entry name" value="PROTEIN FAM8A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="143"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006039-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="334" mass="36726" checksum="C7EE65399102C14E" modified="2016-09-07" version="1">MAENHPAGKEKDNPESAADGTVPQLDLTKSSKQIYFELLRTWVYHAEMQNHLHAHFPYYLMNNYPQLFQLNTGGSVPATGPGMMGSFMAGTGTIANGGSGAAPSSAGQGANGGNANRGRNETTDPTRPDDAINRHGGYEYVIAPLWKRFAAEAIDIAIIFLLKIMTTLAFIDAFEIDLLYMDLDAIRNSFEEDYTELLSFTSELIFLEIGIKIAVCIYEAAWTAHVQVIPGSATPGKMLMGLRIVYAESVAVLEPQPQPGLLSNQVPLRALIYPGTTPSFGRAFARAVVKNVVIAFFFPMCLLLLCFRQNRSIYDVMTKTVVVEDNPNPVLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGM8</accession>
    <name>A0A182PGM8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGM8"/>
    <dbReference type="STRING" id="199890.A0A182PGM8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006087-RA">
        <property type="protein sequence ID" value="AEPI006087-PA"/>
        <property type="gene ID" value="AEPI006087"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006087"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="75"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006087-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="204" mass="23719" checksum="8FEE613BEC6175F3" modified="2023-06-28" version="2">MSCCCLVVSYHLIVNLVDRFSEVLRDIVYCRCRATEELPEQSDDCEQTMDEPVATSVLTNKPRYVVLNDTVELEPFYYDIDRRHCELLLRDRPTGTCIVRPFKMKHATIRYILSIRAPDTYFHLFIRHAGKNGMYALGLEKEQERRFKFPTDIVRYYAVHLLECTRATTCVNVQLQPLPISDLMRDELRPRGGPRIAPDGTKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGS7</accession>
    <name>A0A182PGS7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PGS7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006136-RA">
        <property type="protein sequence ID" value="AEPI006136-PA"/>
        <property type="gene ID" value="AEPI006136"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006136"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046460">
        <property type="entry name" value="UNC80_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045852">
        <property type="entry name" value="UNC80_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031542">
        <property type="entry name" value="UNC80_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19424">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20262">
        <property type="entry name" value="UNC80_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15778">
        <property type="entry name" value="UNC80_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Cation channel complex component UNC80 N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Protein UNC80 central region" evidence="4">
        <location>
            <begin position="1135"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="domain" description="Protein UNC80 C-terminal" evidence="5">
        <location>
            <begin position="1906"/>
            <end position="2986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1488"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1611"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2502"/>
            <end position="2524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2990"/>
            <end position="3092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3157"/>
            <end position="3218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
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        <location>
            <begin position="326"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
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        <location>
            <begin position="1488"/>
            <end position="1497"/>
        </location>
    </feature>
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        <location>
            <begin position="1620"/>
            <end position="1632"/>
        </location>
    </feature>
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        <location>
            <begin position="1643"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2990"/>
            <end position="3004"/>
        </location>
    </feature>
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        <location>
            <begin position="3049"/>
            <end position="3069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3159"/>
            <end position="3170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="3187"/>
            <end position="3208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006136-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="3353" mass="371997" checksum="C37265A619AAF399" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH88</accession>
    <name>A0A182PH88_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PH88"/>
    <dbReference type="STRING" id="199890.A0A182PH88"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006297-RA">
        <property type="protein sequence ID" value="AEPI006297-PA"/>
        <property type="gene ID" value="AEPI006297"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006297"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051298">
        <property type="term" value="P:centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF38">
        <property type="entry name" value="SAC3 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006297-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="362" mass="42245" checksum="2CFC434D804619E0" modified="2016-09-07" version="1">MNEFIRGTCENMCPKAEIDMRIREKMVHFFETDPYTGVAGVPDHSRMVKEFTRSAADRRQPKPCEIRTPRMLLETVHYLLTIVLPDARRPYYQRYEFIFDRMRAIRQEMVIQNLSVGEVLPILEPIVRFLCYSAYRLCEAPIAEFDPKICAQHLQECLKKVLRCYEELDERSEAIDDVNRFEMERLYLSFNIGSTEATQSVIARYGAMEPNLRLHITTQLECHRGNYFAAIRNMFQFAPLEAAVSSLQLPQFRRRLLQQFAIAYQSRVQTVPLEWLESILHYEGRERTCLPDDCRHYNLQLVTKSGGKQQNNDGNSSWTVKFEKAQFDGQRCAIQPRKVPSIDDVLERCGNITKMLLGGFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHD4</accession>
    <name>A0A182PHD4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHD4"/>
    <dbReference type="STRING" id="199890.A0A182PHD4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006343-RA">
        <property type="protein sequence ID" value="AEPI006343-PA"/>
        <property type="gene ID" value="AEPI006343"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006343"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859:SF0">
        <property type="entry name" value="PRA1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859">
        <property type="entry name" value="PRA1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006343-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="190" mass="21135" checksum="CDE9908238BC8C26" modified="2016-09-07" version="1">MTTTQGSGSLGDLHLPPLRSLSDFLLESARFQLPNMQDWEKWGNRVVNNLLYYQTNYFLMSAAVFLLVGLLHPTKVLLGLIIIAALVYVFVRFFAQEARRSVGADPNQQPNKWAVLAGTIAGSYLVLYLFDSVLIVAFAVLLPFTLTFVHASLRLRNIKNKITNAVEIVGVKQSPMGQFLEAMGLMPTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI28</accession>
    <name>A0A182PI28_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="199890.A0A182PI28"/>
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        <property type="term" value="F:chitin binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom_sf"/>
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            <end position="31"/>
        </location>
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            <begin position="32"/>
            <end position="181"/>
        </location>
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    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
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            <begin position="118"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006590-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="181" mass="20208" checksum="85F580950703A51F" modified="2016-09-07" version="1">MTFNQTRLKVIGTLQTIVLLCLLLATSPCNGAVEPILPDNALCPVARCVTYDEVNTLWAVPDAAYFQQCRRKADGGWELQLMPCAPGTLFSYKQQVCVMPPYWQGCAALPDEQRCAAPRCNTYKEVNTLWVHDSADKFYQCRRINGSWAPLELPCAPGTLYSFKHQVCVLPAMWVPSCGDE</sequence>
</entry>
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            <taxon>Pterygota</taxon>
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            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIJ8"/>
    <dbReference type="STRING" id="199890.A0A182PIJ8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006760-RA">
        <property type="protein sequence ID" value="AEPI006760-PA"/>
        <property type="gene ID" value="AEPI006760"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006760"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="439"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
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            <begin position="74"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006760-PA"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIN8</accession>
    <name>A0A182PIN8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Epiroticus2</strain>
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    </reference>
    <reference evidence="2" key="2">
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            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
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        <property type="gene ID" value="AEPI006800"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI006800"/>
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        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006800-PA"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="65556" checksum="DCBF11707E3D1FE3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="8">Phosphofurin acidic cluster sorting protein 2</fullName>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PACS family.</text>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="955" mass="104969" checksum="A2A54BE81494054E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKD6</accession>
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        </submittedName>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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    </organism>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="9">Epiroticus2</strain>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Haas B."/>
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                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
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    <dbReference type="Proteomes" id="UP000075885">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="NAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007553-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39345" checksum="FA6D92878CA67814" modified="2016-09-07" version="1">MADNEATEAATNSPSVPSPTNEPPLEKTEQFLLHQIAVIERRIKDLEMAQSPASSPVPPNIQAKLYALRKIQLEIVDREVQFHLKAHAMECEFQSEFAECQDKIARIVNGQDVPELVDSNPAPNDVADQPKGIPEFWLSVLKSSFLEHMITQTDEPVLKQLQDLRVVLFNEPVPGFELEFHFAPNDCFTNEVLKKKYLLRCAPNPNEPAKFNGFEIYACEGCSIDWKPEHNLVESPGCSFFDFFTPENMTNGDYDADFNEAIMECDFQYGYHIKETIIPRAVFLFLKENVNLGDESHFTCCCDRCVYIDGLNELGGGQSINEEEEEEPAASQEVRSSSPNVEEPESASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKW6</accession>
    <name>A0A182PKW6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKW6"/>
    <dbReference type="STRING" id="199890.A0A182PKW6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007583-RA">
        <property type="protein sequence ID" value="AEPI007583-PA"/>
        <property type="gene ID" value="AEPI007583"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007583"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042418">
        <property type="entry name" value="TXNDC15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14684">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14684:SF2">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="134"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007583-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="299" mass="33628" checksum="7D2EC2158E3B67A1" modified="2016-09-07" version="1">MGLEFYMKLWNGEFLESNTFPGESVAKPDEKAEVAVMETPQLGAQGEKKEQQQCTLFDYLTYWDKVACSADQANDQDDGLGPEGSRKSPLRVKCTPVEGNGTLYIITSLQDIVKGLTPYGGGNNATNRSEVASCFLMLFYTKTCIHSAMVAPHFNALARHFPDLIVTAIDAYNFHFLNAEFGIVGLPTIMLFHQGRPLVKYNGTEISLHSLAKFVTRHTGIEPRLVNQKSGTATVLHYISNDFKGPLSNKVEHRTDYWLYVAWVFILICLSYYFSKSALYAQIVEMIKRNWRESAAQHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLK0</accession>
    <name>A0A182PLK0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLK0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007820-RA">
        <property type="protein sequence ID" value="AEPI007820-PA"/>
        <property type="gene ID" value="AEPI007820"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007820"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007820-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17321" checksum="7B48B22E0A028066" modified="2016-09-07" version="1">MGEKTPSISKVRPLITPASLQISSRGRVVFSIVPAPQQQHQEVGQDADGPAEPFLSPEYINSLGKNVQFSESDVEKMWIYSLGVTLQRTVSSFAVNHQQQQQQQRQHQHEYDVHHLRTEDAPLTPLDHVVLAMCEANLYQRASLMFLLDNLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLN8</accession>
    <name>A0A182PLN8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLN8"/>
    <dbReference type="STRING" id="199890.A0A182PLN8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007858-RA">
        <property type="protein sequence ID" value="AEPI007858-PA"/>
        <property type="gene ID" value="AEPI007858"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007858"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052223">
        <property type="entry name" value="Actin_Cytoskeleton_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271:SF1">
        <property type="entry name" value="PROTEIN OUTSPREAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007858-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="118" mass="13460" checksum="4D0B0D108973CBD4" modified="2016-09-07" version="1">MHRWQRRWFVLYDDGELTYSVDEHPETIPQAIIDMTKVLEVTTADSITSHPHSIAITAPDRVTFVKGTCPEESKWWFNVLVAFPKSKVSSVHIRKGRHKRNATFPGGQATTILQAQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLS5</accession>
    <name>A0A182PLS5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCDC50_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLS5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007897-RA">
        <property type="protein sequence ID" value="AEPI007897-PA"/>
        <property type="gene ID" value="AEPI007897"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007897"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039303">
        <property type="entry name" value="CCDC50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029311">
        <property type="entry name" value="CCDC50_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22115">
        <property type="entry name" value="C3ORF6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22115:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15295">
        <property type="entry name" value="CCDC50_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="564"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="778"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="829"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="839"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007897-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="899" mass="98376" checksum="2CB72A57DD9343D5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMN3</accession>
    <name>A0A182PMN3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="4">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PMN3"/>
    <dbReference type="STRING" id="199890.A0A182PMN3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008207-RA">
        <property type="protein sequence ID" value="AEPI008207-PA"/>
        <property type="gene ID" value="AEPI008207"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008207"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008207-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="323" mass="36430" checksum="EBF575C88EE2B06E" modified="2016-09-07" version="1">MSKVVLVTGGTGLIGKAIETVITEENPANERWIFVGSKDADLTDLAATRQMFLKHQPTHVVHLAAMVGGLFHNMSNNLDFFRKNMLINDNILLLSHELKVKKVVSCLSTCIFPDKTSYPIDETMIHNGPPHDSNFGYSHAKRMIDVLNRAYNQQYGDMFTSVVPCNVFGPHDNFVPGVSHVIPGMIHRLHELMFVKNPDEPQESKVFSVYGTGKPLRQFIYSLDLAKLFVWVVREYNSVEPIILSVDESAEVSIAQLAQSLAKAFDFKGSLDFDTTKADGQYKKTASNAKLRKHLPNFKFTDFDVAIKDTVQWYIANYEKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMN7</accession>
    <name>A0A182PMN7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="11">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19254"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182PMN7"/>
    <dbReference type="STRING" id="199890.A0A182PMN7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008211-RA">
        <property type="protein sequence ID" value="AEPI008211-PA"/>
        <property type="gene ID" value="AEPI008211"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008211"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061750">
        <property type="term" value="F:acid sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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    <sequence length="657" mass="75426" checksum="66DE7284D78AA424" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN46</accession>
    <name>A0A182PN46_9DIPT</name>
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        <submittedName>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="11">Epiroticus2</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN79</accession>
    <name>A0A182PN79_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
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    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Howell P."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PN79"/>
    <dbReference type="STRING" id="199890.A0A182PN79"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008404-RA">
        <property type="protein sequence ID" value="AEPI008404-PA"/>
        <property type="gene ID" value="AEPI008404"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008404"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="5">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008404-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="380" mass="43829" checksum="FF8A7D32FD002678" modified="2016-09-07" version="1">MQAKCRLCLKKVGARKGLSINDSNFSTLLSRVFIFPVSQIEPNLPQGVCSRCVSTVRNFHDYSQEVQQNQTFLLQGLITKRKGSEEDHTKWEAAVTVKHEFPPDADDKTESFPELNDDEGEEDASDIIMPIEDVELTENEQEDFLSDDERSRNFDTLAPDDGNAIGRSRKSELHENDRIIQEFFKMRCELCPEQDEHSFDRFYTLQLHYRRQHQTRGYVRCCGVQLYRRFRVMEHIESHRGTIRCEICEKLFKSYSYLRRHMAERHLDGGIDRASYTCEHCKRKFSTAGQLTVHRQSHVTTVCKLCGKTVSMRYLKKHVALIHEAVRNWYMCDLCGKNFSSSMVLDRHIKHHQGIETLLSVVCTPSSSGSASSNGSSNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PND9</accession>
    <name>A0A182PND9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Actin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PND9"/>
    <dbReference type="STRING" id="199890.A0A182PND9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008466-RA">
        <property type="protein sequence ID" value="AEPI008466-PA"/>
        <property type="gene ID" value="AEPI008466"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008466"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000188">
        <property type="entry name" value="Actin like 6B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000008">
        <property type="entry name" value="alpha-centractin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008466-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42644" checksum="2FA7B2394199951C" modified="2016-09-07" version="1">MEPYDVIVNQPVVIDNGSGMIKAGFAGDHIPKCRFPNYMGRPKHVRVMAGALEGDMFVGPKAEDYRGLLSIRYPMEHGIVTDWNDMEKIWMYIYSKDELSTFAEEHPVLLTEAPLNPRKNREKAAEIFFETFNVPALFVSMQAVLSLYATGRVTGVVLDSGDGVTHAVPIFEGFAMPHSIMRVDIAGRDVTRYLKTLIRKEGFSFRTTAEFEIVRSIKEKVCSLATNPLKEETVDTEKTKYVLPDGNVLEIGPACYRAPEVLFRPHMLGEECEGIHEVLIYSIQKSDMDLRKMLYQNIVLSGGSTLFKGFGDRLLSEIRKHVAKDMKIRIAAPQERIYSTWMGGSILASLDTFKKMWVSKREFDEDGQRAIHRKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNE7</accession>
    <name>A0A182PNE7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNE7"/>
    <dbReference type="STRING" id="199890.A0A182PNE7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008474-RA">
        <property type="protein sequence ID" value="AEPI008474-PA"/>
        <property type="gene ID" value="AEPI008474"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008474"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
        <property type="term" value="P:heme export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000092">
        <property type="entry name" value="Feline leukemia virus subgroup C receptor-related protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF4">
        <property type="entry name" value="GH15861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008474-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="268" mass="29172" checksum="898EDA364664452B" modified="2016-09-07" version="1">MLVENHDDISLIGDDLRLMFYIVAGFTSILVVLVLCFFKAAPPTPPSAAQEATKTPNPLQSSPFLHSIKRLMLNRNYVLLLISYGMNVGVFYAISTLLNQIVLTHYPGHEVDAGRIGVCIVFAGMLGSVACGIVLDKTHRFKETTLAVYIFTMIGMWIYTFTLSVGHIAVVYVTSSLLGFFMTGYLPVGFEFAAELTYPEPEGTSTGLLNAAAQVFGITFTMLYSELLNTNGDIVANVTMAVMLLVGSVVTAVIRSDLRRQAAQNPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNH0</accession>
    <name>A0A182PNH0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AF4/FMR2 family member lilli</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Protein lilliputian</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AF4 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PNH0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008497-RA">
        <property type="protein sequence ID" value="AEPI008497-PA"/>
        <property type="gene ID" value="AEPI008497"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008497"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007366">
        <property type="term" value="P:periodic partitioning by pair rule gene"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007797">
        <property type="entry name" value="AF4/FMR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043640">
        <property type="entry name" value="AF4/FMR2_CHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528">
        <property type="entry name" value="AF4/FMR2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528:SF17">
        <property type="entry name" value="AF4_FMR2 FAMILY MEMBER LILLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18876">
        <property type="entry name" value="AFF4_CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0562">Pair-rule protein</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AF4/FMR2 C-terminal homology" evidence="14">
        <location>
            <begin position="1455"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="96"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="315"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="516"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="948"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1065"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1293"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1580"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="687"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="948"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="995"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1103"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1142"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1307"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1342"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1383"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1580"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1593"/>
            <end position="1607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008497-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1702" mass="179668" checksum="DBA39912A038082F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNZ1</accession>
    <name>A0A182PNZ1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidylcholine transfer protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">START domain-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">StAR-related lipid transfer protein 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with ACOT13/THEM2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNZ1"/>
    <dbReference type="STRING" id="199890.A0A182PNZ1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008670-RA">
        <property type="protein sequence ID" value="AEPI008670-PA"/>
        <property type="gene ID" value="AEPI008670"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008670"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08911">
        <property type="entry name" value="START_STARD7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000017">
        <property type="entry name" value="Phosphatidylcholine transfer protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041949">
        <property type="entry name" value="START_STARD7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF8">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="13">
        <location>
            <begin position="177"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="421"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008670-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="484" mass="56769" checksum="75C7C2B1E3CC2232" modified="2016-09-07" version="1">MAMKLIPNSTLALRKFNKYLRRNVKDRSASILRLWTTQCEFVFAQQLRRSQQILTHYAKIWEERALRELLKRFRGQVRAPGGTARLGDVQRHAKGVMLSSAALLTWDWERERIELDSVQEHMDDFKFLERLQLETIYCKRCQKRKLIDCRVEGINYCNCPKNVTEMLSAEQNVYTAWEPYIEQKRMITWRQEIKPGLFAYKVYVEYPDVTAEDFLHVQIDVEYRKKWDNTAVNLEVIDEDDANGSNSHIIYWEALWPKLFANRDYVYNRRFFIDRSRRVIMIVNKSVEHPKCPAKPHTQRVHEYWSYMVIKPTTAFNKPGVSFVLTYFDNPGLSIPKYITTWVAKKQMPDFLQQLHQATVNYAKAKKQNETRIIEFWDKHKDPGFEYPPDTLLGYSAEDFSEAQKQEEESSLQQVLKNNVESKGTSQPLPSATAKSSVESAQLNDKSSSSSATAVDSGESILEESAPVQKMSWWSYLYSYIYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR15</accession>
    <name>A0A182PR15_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PR15"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009396-RA">
        <property type="protein sequence ID" value="AEPI009396-PA"/>
        <property type="gene ID" value="AEPI009396"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009396"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF69">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009396-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="128" mass="14475" checksum="E86AB5BA983A9069" modified="2016-09-07" version="1">MRSPPFGDAKIPEELVSAVMQVLLGEKNYSADGDYSAPYLKPVVARIYPLFILLYAIPTALGLTLNVMIIVYVSKYKLYRDVTHAFLVNLAVCHCVQSLFVLPITLMVMIIQNWVFGQFLCFFLPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRB0</accession>
    <name>A0A182PRB0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRB0"/>
    <dbReference type="STRING" id="199890.A0A182PRB0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009494-RA">
        <property type="protein sequence ID" value="AEPI009494-PA"/>
        <property type="gene ID" value="AEPI009494"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009494"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF473">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="278"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="219"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009494-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="363" mass="38850" checksum="6CB1101E52C05924" modified="2016-09-07" version="1">MGCSAVQQQPGATNQGQSAQSPIAQTMAPSAGNTIVIVRQAGPTPPTAVPSASPPSSLPQQQQHAEAATKSLKTSHSALVKILESAPLNAVKSTASSAPSTNSNITNAPPVVAVTPKIDFCPWKKTTIAKEWLSAQSGVKQREEAPSVVVLAGPRLEGQEHQQQQQQQRGLVICAIEKKEEQKKEQEVAMEEDEAIEAGCEEDEEDELESRLASKKARSSSSSSSSCSSSGNSSCRSRESSLSSAASPEPNSSGDESSSSSSGLSSGERSSSSSSSSAPSCCTCSSDHLINDLCQQFEENLCEDHVRFNRPRLGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRL5</accession>
    <name>A0A182PRL5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRL5"/>
    <dbReference type="STRING" id="199890.A0A182PRL5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009599-RA">
        <property type="protein sequence ID" value="AEPI009599-PA"/>
        <property type="gene ID" value="AEPI009599"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009599"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002075">
        <property type="entry name" value="zinc finger protein 646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009599-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="445" mass="51421" checksum="7B2A93F3472426A5" modified="2016-09-07" version="1">MNFFIPNEVKREGIYLQHQLGPPLIHQQHHQLPQQSQHQLLGFPHPGMIVNLKKEQFDPYEKLPDGQGHNQQHVLQLQQQAQMVGLQQHISAQMQSQLAAQQQQQQQQQQHQQQQQPHQQQQQQQQQQQQQQQQQPQSQQQQQQQQTPQAQSSTASTASTTPTTTTTSTSSTTTNTTGTGKKKKKGKANRNIVIPQLPEGFIVKVKEEYTENYVRTVTKIPEEQFIRTVKSPGKKERKYHDYNAVSEHQCDVCGKYFKDKYKLNYHVRIHVPELSHRCDVCGKVFAHQSTLHNHKRIHTGERAFKCLTCGKAFVQSSALSNHTKIHTGERPHECLICGISFIQKINLIYHIRIHNGERPYRCNICQKSFIQQSHIKNHMKVHKKDNPLDCSMCGKNYSDLNELTEHYATHHTAELSYRCQACGKSFAQANHLKIHKKNFCNSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRN6</accession>
    <name>A0A182PRN6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM256 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRN6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009621-RA">
        <property type="protein sequence ID" value="AEPI009621-PA"/>
        <property type="gene ID" value="AEPI009621"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009621"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009621-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="178" mass="19491" checksum="BE2EA6EB35AA30DE" modified="2016-09-07" version="1">MGLNDAFNYVLFNNPVSSTMWSMAAQGAKAAGLKPKAVTQTAATHTKAVVEQALPPLWKLLGVNRHIVRLAGLSGAAAVVLGAYGAHYHFTPKDENTQERDPKQIFEMTNRYHFIHSLALLAAPLARRPYLTTTLIASGMSLFCGTCYYLAFTNDRRAAQLTPMGGFLLIFGWLSFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRP9</accession>
    <name>A0A182PRP9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integrator complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRP9"/>
    <dbReference type="STRING" id="199890.A0A182PRP9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009634-RA">
        <property type="protein sequence ID" value="AEPI009634-PA"/>
        <property type="gene ID" value="AEPI009634"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009634"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000728">
        <property type="entry name" value="Blast:Integrator complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056235">
        <property type="entry name" value="INTS4_8HBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057412">
        <property type="entry name" value="INTS4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938:SF0">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24493">
        <property type="entry name" value="INTS4_8HBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25458">
        <property type="entry name" value="INTS4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTS4 8 helical bundle" evidence="3">
        <location>
            <begin position="608"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 4/Protein SIEL C-terminal Ig-like" evidence="4">
        <location>
            <begin position="812"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009634-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="940" mass="104644" checksum="76F4E0289F31E0B9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS07</accession>
    <name>A0A182PS07_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PS07"/>
    <dbReference type="STRING" id="199890.A0A182PS07"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009742-RA">
        <property type="protein sequence ID" value="AEPI009742-PA"/>
        <property type="gene ID" value="AEPI009742"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009742"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="655"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="715"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009742-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="761" mass="87306" checksum="8BC3DBFEEDA718F6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSJ7</accession>
    <name>A0A182PSJ7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSJ7"/>
    <dbReference type="STRING" id="199890.A0A182PSJ7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009932-RA">
        <property type="protein sequence ID" value="AEPI009932-PA"/>
        <property type="gene ID" value="AEPI009932"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009932"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031986">
        <property type="entry name" value="GD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16030">
        <property type="entry name" value="GD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131820" description="Peptidase S1 domain-containing protein" evidence="4">
        <location>
            <begin position="45"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="261"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009932-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="512" mass="56418" checksum="F610D809B5F38715" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PT04</accession>
    <name>A0A182PT04_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ML domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PT04"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010090-RA">
        <property type="protein sequence ID" value="AEPI010090-PA"/>
        <property type="gene ID" value="AEPI010090"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010090"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="2">
        <location>
            <begin position="12"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010090-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="161" mass="18657" checksum="9C49219C7FC98CC2" modified="2016-09-07" version="1">MMGRLFGFYNVVTYDNCKHMENPAATLSKVKVSGKPNAIELSAIMDVTQEIEPPVHMQLSVKRCNLQKEGCETYEHISMEDICSKIDSNPILHKYMDVFTPPLSCPLKKGRYVAEKAELKLHMLEMFPIENAFWQMEFRFMNKHNQTMQCDFVEIAVTDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTG4</accession>
    <name>A0A182PTG4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PTG4"/>
    <dbReference type="STRING" id="199890.A0A182PTG4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010250-RA">
        <property type="protein sequence ID" value="AEPI010250-PA"/>
        <property type="gene ID" value="AEPI010250"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010250"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010250-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="482" mass="54376" checksum="5481EF20E12249CE" modified="2016-09-07" version="1">MQFCGVFPLQRTTMLIAVIIIGSFLVSGGAATRIAPDTFHEAVNTTLIELDDNYLEELPVELLAGLTHLRVFAASNNKIKSVPEELFLENLEVKEIRLSNNFFKTLPSKFFAELPILEELYLDRNNLVALHDDAFVDCPMLRVLDLGYNRLVSIPVRIFEQQKESIQSLNLRANHLSSLEFIKGLKLLTALNLEANQVSVLQGGEFDGTPNVTHLWLAYNDLHQLTSESFRGLNMLRVLGLSNNAIEFIEPDTFAALKTLNELYLNGNHIKSLPDSVFLALGETLQILSLRDNRLEQVPVTIIQNLPKLQELDLSSNPIANLSERILQYNLNIARLSLTDVRLQRIGKKFLPNPKLITFLSLERCFIEEIDPEAFWSFGSLYSSELHLSQNELTILPKGLFRTSGLLRVLNLSYNLLTRLNPDTFASNSSLEELYLEGNKINQLTVGNFGIFPVLKILSLRNNCIEWIAEVFPSLMVLGLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTI8</accession>
    <name>A0A182PTI8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="16">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Golgi apparatus membrane</location>
            <topology evidence="2 16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A182PTI8"/>
    <dbReference type="STRING" id="199890.A0A182PTI8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010274-RA">
        <property type="protein sequence ID" value="AEPI010274-PA"/>
        <property type="gene ID" value="AEPI010274"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010274"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23434">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000065">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000021">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF119">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 16" id="KW-0430">Lectin</keyword>
    <keyword evidence="15 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="17">
        <location>
            <begin position="410"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010274-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="535" mass="61086" checksum="0CDB31F6B6388F7E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU70</accession>
    <name>A0A182PU70_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU70"/>
    <dbReference type="STRING" id="199890.A0A182PU70"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010506-RA">
        <property type="protein sequence ID" value="AEPI010506-PA"/>
        <property type="gene ID" value="AEPI010506"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010506"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010506-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="393" mass="45555" checksum="7F029BDEECA40BEA" modified="2016-09-07" version="1">MEYIQRWILRDDTFAEKVYVKYNFDNLRTIGIYRDASKACLARRAVFFAQEIFFLLQICTVVWDLAAVLNDIGLFGDDLCILAGLLLTLTKKWHCVVNIDELDECVGQFQLYHEHYLQQGDWFVRCMRRQDMQERMLQDASKLLAIMLASCLMVNALFSNGETLILRATYPFSTSTTLGYGCVFLCQAFLIIYVLYSMVLIDCIGAQILSQMSLLFSMQRKQFEMIGTDLHLPPDGPLHGEHSIRAQVHRAIVSHQQLLAFCNRLKRLYEPNIMAQFVCSMLIICLTAFELMFAKGDPMQMIRFGAYMLTGFYQIFVWSFFGNRSTGISDATINCNWMVLVDGLKKDLRFATMRSQKPFIIDVYWLFPLTYETFIAILSRSYSIFTLLRTMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUE6</accession>
    <name>A0A182PUE6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUE6"/>
    <dbReference type="STRING" id="199890.A0A182PUE6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010582-RA">
        <property type="protein sequence ID" value="AEPI010582-PA"/>
        <property type="gene ID" value="AEPI010582"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010582"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004977">
        <property type="term" value="F:melanocortin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000233">
        <property type="entry name" value="CLUMA_CG012980, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001671">
        <property type="entry name" value="Melcrt_ACTH_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00534">
        <property type="entry name" value="MCRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010582-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="103" mass="12026" checksum="B2302A4C1F0A9CDC" modified="2016-09-07" version="1">FTIYKVNKASKKKREKSSAKKERKATKTLAIVLGVFLFCWVPFFTCNIMDAMCAKLEKDCRPGVTIFNLTTWLGYMNSFVNPVIYTIFNPEFRKAFKKIMHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUU8</accession>
    <name>A0A182PUU8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUU8"/>
    <dbReference type="STRING" id="199890.A0A182PUU8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010735-RA">
        <property type="protein sequence ID" value="AEPI010735-PA"/>
        <property type="gene ID" value="AEPI010735"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010735"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF166">
        <property type="entry name" value="LD40136P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="47"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010735-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="254" mass="29339" checksum="B85610BD10446DE1" modified="2016-09-07" version="1">MDSKFLLRFLRFRQFSVPMACEALEQYLTMREMYPSWFKNLDASNEKMKELFDGGATSIMGQDSNGRTVVFFRIARFVPEMFEPPVGGIFIALLIEAMLEWEEVQIGGLQVMLDYSDLDIKLFEKWGSSELKLIMEAYTRWYPLRVNDTHAAKLPKKALPVIEKLLSFTNPKIRERINCYANVSEMEKHFEPAMAPKGYGGNVDLDADVNPAMWKRIEQQSDVILGLDQMEIDYDYYAPIWDQQNAGLVEMPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUY7</accession>
    <name>A0A182PUY7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="14">TDO</shortName>
            <ecNumber evidence="14">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Tryptophan oxygenase</fullName>
            <shortName evidence="14">TO</shortName>
            <shortName evidence="14">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="14">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 14">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Pigment biosynthesis; ommochrome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13 14">Homotetramer. Dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A182PUY7"/>
    <dbReference type="STRING" id="199890.A0A182PUY7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010774-RA">
        <property type="protein sequence ID" value="AEPI010774-PA"/>
        <property type="gene ID" value="AEPI010774"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010774"/>
    <dbReference type="UniPathway" id="UPA00271"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:L-tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019442">
        <property type="term" value="P:L-tryptophan catabolic process to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006727">
        <property type="term" value="P:ommochrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3810:FF:000001">
        <property type="entry name" value="Tryptophan 2,3-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="TRYPTOPHAN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138:SF0">
        <property type="entry name" value="TRYPTOPHAN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1 14" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0408">Iron</keyword>
    <keyword evidence="3 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9 14" id="KW-0823">Tryptophan catabolism</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="16">
        <location>
            <begin position="457"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="15">
        <location>
            <begin position="571"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010774-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="806" mass="91706" checksum="587DF76B7EEE7F07" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV39</accession>
    <name>A0A182PV39_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PV39"/>
    <dbReference type="STRING" id="199890.A0A182PV39"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010826-RA">
        <property type="protein sequence ID" value="AEPI010826-PA"/>
        <property type="gene ID" value="AEPI010826"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010826"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131952" evidence="1">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010826-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="101" mass="11414" checksum="4D6BA8200607794F" modified="2016-09-07" version="1">MATLLYTIIGMTASASLNCAVRREISPCTCSPGLFANNIDVKCEQMESFGQVVNALQDRFTEDHNIWLTISHSQLLDLAALSFWEMNMNIKSLRINFDNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVP4</accession>
    <name>A0A182PVP4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4'-phosphopantetheine phosphatase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Inactive pantothenic acid kinase 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:68340"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:177302"/>
            <dbReference type="ChEBI" id="CHEBI:177303"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:68341"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Interacts with PKM.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVP4"/>
    <dbReference type="STRING" id="199890.A0A182PVP4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011031-RA">
        <property type="protein sequence ID" value="AEPI011031-PA"/>
        <property type="gene ID" value="AEPI011031"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011031"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1700.10">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035073">
        <property type="entry name" value="At2g17340_3_helix_bundle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF35">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0533">Nickel</keyword>
    <keyword evidence="8" id="KW-0944">Nitration</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="13">
        <location>
            <begin position="54"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011031-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="366" mass="41716" checksum="08A49B9BEDA4167E" modified="2016-09-07" version="1">MGTEGNPTPGRFSHCTLLANAEAYNPDTLDLYQDPEANQYWFACFNEMVLKFERQALASQSKDATAAARAQSFREHCTQMLVQLQEGKRQSDTLGIRNLLEVIESALRKFGFDDPWKEQKTIENRASIDMLNQRLLQLDNIICRRERWAEIVRGVLAGNMFDWGAQAVTKILETNNGFGLQQALNRIQKRPWLIDDLDGWLDKMEHEPPHKCATIFTDNAGIDFVLGIVPLVRELLKRDTKVLLCATLNPAINDITYSELVRAIVECCEECDILRDAYSKNHRLLLFGNDQIGPCLDFRMLSKDLSEAIEQNNVDLLIIVGMARALHTNLYAKFVCETLKLAVVKNEWLAKRLGGETFSVVCKYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVX5</accession>
    <name>A0A182PVX5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVX5"/>
    <dbReference type="STRING" id="199890.A0A182PVX5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011112-RA">
        <property type="protein sequence ID" value="AEPI011112-PA"/>
        <property type="gene ID" value="AEPI011112"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011112"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13905">
        <property type="entry name" value="CuRO_3_tcLLC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000031">
        <property type="entry name" value="Laccase-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="77"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="201"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="488"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011112-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="658" mass="74725" checksum="6F9121D837121B74" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVX7</accession>
    <name>A0A182PVX7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytoplasmic protein NCK1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVX7"/>
    <dbReference type="STRING" id="199890.A0A182PVX7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011114-RA">
        <property type="protein sequence ID" value="AEPI011114-PA"/>
        <property type="gene ID" value="AEPI011114"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011114"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09943">
        <property type="entry name" value="SH2_Nck_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11765">
        <property type="entry name" value="SH3_Nck_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11766">
        <property type="entry name" value="SH3_Nck_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11767">
        <property type="entry name" value="SH3_Nck_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000110">
        <property type="entry name" value="Cytoplasmic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000027">
        <property type="entry name" value="Cytoplasmic protein nck1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017304">
        <property type="entry name" value="NCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF14">
        <property type="entry name" value="DREADLOCKS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037874">
        <property type="entry name" value="Cytoplasmic_NCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="117"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="188"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="303"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011114-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45736" checksum="A3BC0A37790208A7" modified="2016-09-07" version="1">MAGSIKQDDVCYVVAKYDYEAQGAQELDLRKNDRYLLLDDSKHWWRVQNTRNQSGYVPSNYVKKEKKSVSLFDSFKKKVKKGSGSKTLPNCSPSRQVDSPTMSRRLPPDPSEAIASTPIGTAIVKYNYQAQQQDELSLTKGTRILILEKSNDGWWRGQSGSATGWFPSNYTTEENEDDTLHTYAMAENVLDIVVALYSFNSNNDTELSFEKGDRLEILDRPAADPEWYKARNNNGQIGLVPRNYLQELSEYLAQPFRSNGSGPDSLDRRPNDAQSNNNNSNTNNSNNNNSQQPERPHLTGKSWYYGAITRSQCDTVLNSHGHDGDYLIRDSETNLGDYSVSLKAPGRNKHFRVHVEGNMYCIGQRKFHTLDQLVDHYQRAPIYTNKQGEKLYLVRPLPKANGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW75</accession>
    <name>A0A182PW75_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PW75"/>
    <dbReference type="STRING" id="199890.A0A182PW75"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011212-RA">
        <property type="protein sequence ID" value="AEPI011212-PA"/>
        <property type="gene ID" value="AEPI011212"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011212"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="415"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011212-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="644" mass="74575" checksum="677B654710938DBD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWA6</accession>
    <name>A0A182PWA6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DOMON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWA6"/>
    <dbReference type="STRING" id="199890.A0A182PWA6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011243-RA">
        <property type="protein sequence ID" value="AEPI011243-PA"/>
        <property type="gene ID" value="AEPI011243"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011243"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF40">
        <property type="entry name" value="MOXD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131866" evidence="1">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="2">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011243-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="97" mass="10402" checksum="385EA38A885FB7DA" modified="2016-09-07" version="1">MSLPGVMLAVVLLVLASVVSCATGAHWDHAIFLDDDYRLLWSITGQDITFEVQARTHGYIGLGFSKDGTIYGADMVIGWVDQGQVHFQSMIASAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWG1</accession>
    <name>A0A182PWG1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWG1"/>
    <dbReference type="STRING" id="199890.A0A182PWG1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011298-RA">
        <property type="protein sequence ID" value="AEPI011298-PA"/>
        <property type="gene ID" value="AEPI011298"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011298"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="85"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="182"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011298-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="242" mass="26864" checksum="F6BEEBAB02AC1EEE" modified="2016-09-07" version="1">MEGYQGHPVLVQALAQESVQELGRESVRELARESVQELVQVSGQLLVGGWELLECLVDVVERLIVLISLAALNIVAGRIINQRNEPACSVGDDFFVPGPECFNFYFCQNGVLDLIDCPPGLLWNDVTKRCDSAENVECDDEQTTEITQAPTTEAPTPEPTTSTPSNTFMPEVEGALPILFPGSECPEDIRAFLLHATDCRRFYYCLYGVQYPQMCPFLETFNFVVGHCVPQDQSFCFPGSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWI5</accession>
    <name>A0A182PWI5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWI5"/>
    <dbReference type="STRING" id="199890.A0A182PWI5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011322-RA">
        <property type="protein sequence ID" value="AEPI011322-PA"/>
        <property type="gene ID" value="AEPI011322"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011322"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
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        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
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        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
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        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011322-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="508" mass="54141" checksum="07ADE38AF804111F" modified="2016-09-07" version="1">SPYSVQPSGASASPSSKFRCDQCNISFGSKSAHTSHMKSHAKQQQQRQGSGCKQEQDTAANSGTEGSGPSSALESVGSGSGSNSNSSFDFSSSQTEGAEQGPSSDEPSSSGTAGHFAIRKQSPASPSTVRSPVQQVVAEEEEDEEDEDEAEESDRKEITPYDGGMTHSYDQSLQRGYGGGVAPALLAAASIAAAVENGCGDVKFCPEIKQQRSISPEHQSALSITRITPPPSSGSSSSSSSSSSTSSSSSSILSLPSTTGACSTLLEPTGAGMASSSGQYVYEPLAIMKHHGYFAPASQITEFRSSSDIVRQVEAAIAGTENLLTPPRSSPESPDRSSSPESDSVLMANRDNNTLPPRKRKLYFKDSQQQQSTGPKLASLEVASHHYGVAQQPMALQHQQQPLPLDAHSGQQQHFHPQHHHLQQPQQQPHYHQLQRLEEEQRSMKLEVLQNVAQCHREQRQPAASSSPPSPPQQQQQQQQQHPCAPQPAAGTSVIRMSSVIQYANKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWK9</accession>
    <name>A0A182PWK9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWK9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011346-RA">
        <property type="protein sequence ID" value="AEPI011346-PA"/>
        <property type="gene ID" value="AEPI011346"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011346"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011346-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="204" mass="23085" checksum="1BB0803567FFC58E" modified="2016-09-07" version="1">MDRKVAHDEEAGPSREARPTTQRTPECKSETGDVVDATVEKHAVADRVEMIEKGELGLHYIKPRGVKQVKSECKKKKKASTEEKGVNALLAKYVEELKKKEEELEKARLEIANLKRDQCRAVDNPCMTSDNARKWTEENESSTDSEDLSSGDRELDSEGEAEEEEKPLTRRQESARQRLSMDLPPFDGSPEVEEESKRRRIGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PXU6</accession>
    <name>A0A182PXU6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PXU6"/>
    <dbReference type="STRING" id="199890.A0A182PXU6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014170-RA">
        <property type="protein sequence ID" value="AEPI014170-PA"/>
        <property type="gene ID" value="AEPI014170"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014170"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014170-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="67" mass="7628" checksum="2DBF3A21F03B3659" modified="2016-09-07" version="1">MDLYKNSRLGNRIVQTRYGRLQGLVLPLDGYKFLKPIEAFLGVPYATPPTKMNRCLDGFELINIIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYQ7</accession>
    <name>A0A182PYQ7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYQ7"/>
    <dbReference type="STRING" id="199890.A0A182PYQ7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014450-RA">
        <property type="protein sequence ID" value="AEPI014450-PA"/>
        <property type="gene ID" value="AEPI014450"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014450"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="8">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014450-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="306" mass="34574" checksum="55E13EBF72FC2CD8" modified="2016-09-07" version="1">MEEASTSCSANSASNALKRRKQYHTLLDYGHNLALRTQTDDAFAIFEGVSSMLVETNNLHKGMELERAKNCSEMNINVQIIKMGHDLVGAALQKSESSQFCEEELTAAIKAVVGESGNYSQWMQIGALGVKSFRMSKQSPILLGAFEFQPVAVERTVKERRRRQRQELGDPRKPQTVVKLQQEETDARKLQGIMEQLKSICLQRRKSIPYFELITDPTDYMNTVDTAFQISFLIRDGAVALESVDNVLSVRPTSDTERQQNKRNDDNVQAILSLNYAAWKGAIQKFRLKRPILTIERDLLDASQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PPV9</accession>
    <name>A0A240PPV9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 21">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="21">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.</text>
            <dbReference type="EC" id="3.4.15.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 20 21">Belongs to the peptidase M2 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="21"/>
    <dbReference type="AlphaFoldDB" id="A0A240PPV9"/>
    <dbReference type="STRING" id="199890.A0A240PPV9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015379-RA">
        <property type="protein sequence ID" value="AEPI015379-PA"/>
        <property type="gene ID" value="AEPI015379"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015379"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1370.30:FF:000004">
        <property type="entry name" value="Angiotensin-converting enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF44">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 21" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9 18 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14 21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 21" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 22" id="KW-0732">Signal</keyword>
    <keyword evidence="7 17 21" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013303483" description="Angiotensin-converting enzyme" evidence="22">
        <location>
            <begin position="20"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="13">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="15">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="13">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="15">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="14">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) (complex) asparagine" evidence="14">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18 20">
        <location>
            <begin position="142"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18 20">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18 20">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036868"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039858"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015379-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="633" mass="73556" checksum="BB7F082D8635B716" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FGL1</accession>
    <name>A0A9I3FGL1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A9I3FGL1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015524-RA">
        <property type="protein sequence ID" value="AEPI015524-PA"/>
        <property type="gene ID" value="AEPI015524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39945">
        <property type="entry name" value="FI14129P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39945:SF1">
        <property type="entry name" value="FI14129P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039904149" description="Secreted protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015524-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="16272" checksum="E00E755CC62AD5A9" modified="2023-06-28" version="1">MAFKSSTKMMNSVRIVFVLVCLVSLASHSTARPSSVRHSRQLRLIDHLLRSRTAAEGRTHHNHHTPNHQHQRRSADYEDYYDADYKRVQQCYEDEDINELCQRCSKVTKSSIVFPMCCNNEDHTMTWCREYVYYGIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZQ3</accession>
    <name>A0A182NZQ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATPase protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATPase subunit c</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZQ3"/>
    <dbReference type="STRING" id="199890.A0A182NZQ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000134-RA">
        <property type="protein sequence ID" value="AEPI000134-PA"/>
        <property type="gene ID" value="AEPI000134"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000134"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000003">
        <property type="entry name" value="Atp synthase f complex subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="15">
        <location>
            <begin position="59"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000134-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="125" mass="13308" checksum="15B970E9E7FC1FF2" modified="2016-09-07" version="1">MAKYRAPALIKDSRGTFVWSRMLTAGRSPSCPTDAPNTFSRHLSTSCPRRDVDTAAKFVGASLATIGVGGSGLGIGTVFGALIIGYARNPTLKQQIFSYAILGFALSEAMGLFSLMMAFLMLFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P041</accession>
    <name>A0A182P041_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bursicon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bursicon subunit alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of burs and pburs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P041"/>
    <dbReference type="STRING" id="199890.A0A182P041"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000273-RA">
        <property type="protein sequence ID" value="AEPI000273-PA"/>
        <property type="gene ID" value="AEPI000273"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000273"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038098">
        <property type="term" value="P:sequestering of BMP from receptor via BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF7">
        <property type="entry name" value="BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CTCK" evidence="10">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="51"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000273-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="149" mass="16690" checksum="CF212B219E7E222A" modified="2016-09-07" version="1">MWSSSSVRPASNPSALVHHTRLWSEDGRSHYSAADDCQVTPVIHVLQYPGCVPKPIPSFACIGRCASYIQVSGSKIWQMERSCMCCQESGEREASVSLFCPKAKNGEKKFRKLLTVVCFVQSAANWCHQKCQVNFHSWLPNFSKLSGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0A9</accession>
    <name>A0A182P0A9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P0A9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000341-RA">
        <property type="protein sequence ID" value="AEPI000341-PA"/>
        <property type="gene ID" value="AEPI000341"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000341"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF40">
        <property type="entry name" value="IONOTROPIC RECEPTOR 41A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="598"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1054"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1255"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="347"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="991"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000341-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1287" mass="145356" checksum="5A5797B91143998D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0F9</accession>
    <name>A0A182P0F9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
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        <subcellularLocation>
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        <property type="entry name" value="protein atonal homolog 7"/>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
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        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
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        <property type="entry name" value="TRANSCRIPTION FACTOR ATOH7"/>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000391-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="307" mass="32955" checksum="BADB0C68422C1138" modified="2016-09-07" version="1">MSSAYVQQQYNHAAMYGGGGMMSSGAGGMMDTSSYNHYNGMSAMSMGGTGLCYGYGTDSGSSEGYHSPGPVSSPESYYNNAEYSPSSPYTNYGYCSGGSGSGVQGTHHTNNSTNTGNQNGSCESYYNYTGNNFKTASPTVPRYGMTEATNSSTDRSVLSNNYLKREDAAQSLEVQNALRPSTSCVATKRPAIVAQHLPLSGSYYNPYTVPMARNRSSPAHSSSSSASPTPSQSSGQSIVVVQPEIVKKRRLAANARERRRMNSLNDAFDRLRDVVPSLGNDRKLSKFETLQMAQTYIAALNELLSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0G9</accession>
    <name>A0A182P0G9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAP-ZIP_m domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P0G9"/>
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        <property type="gene ID" value="AEPI000401"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000401"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="5"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1539"/>
            <end position="1562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000401-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1562" mass="170708" checksum="E1FC645407A38E72" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0Q2</accession>
    <name>A0A182P0Q2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like-conjugating enzyme ATG3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Autophagy-related protein 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A182P0Q2"/>
    <dbReference type="STRING" id="199890.A0A182P0Q2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000484-RA">
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        <property type="gene ID" value="AEPI000484"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000484"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Trithorax-like, isoform C"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
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        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015318">
        <property type="entry name" value="Znf_GAGA-bd_fac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09237">
        <property type="entry name" value="GAGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="346"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="96"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="620"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017573"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000484-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="807" mass="88372" checksum="A3F231458E6AA3F7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1C1</accession>
    <name>A0A182P1C1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serendipity locus protein alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1C1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000703-RA">
        <property type="protein sequence ID" value="AEPI000703-PA"/>
        <property type="gene ID" value="AEPI000703"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000703"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007349">
        <property type="term" value="P:cellularization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.810">
        <property type="entry name" value="Vinculin, Vh2 four-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008837">
        <property type="entry name" value="Serendipity_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF33">
        <property type="entry name" value="RE47911P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05482">
        <property type="entry name" value="Serendipity_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000703-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="74854" checksum="CC0920CC632260BF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1N8</accession>
    <name>A0A182P1N8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1N8"/>
    <dbReference type="STRING" id="199890.A0A182P1N8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000820-RA">
        <property type="protein sequence ID" value="AEPI000820-PA"/>
        <property type="gene ID" value="AEPI000820"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000820"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="31"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="15">
        <location>
            <begin position="229"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000820-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="404" mass="46502" checksum="14C8364DA3EB2F24" modified="2016-09-07" version="1">MSTFPGTIPELPGIGIDRFDQSVRDRATLFFLSHCHFDHMQGLPEATPLPGPLYASPHTAVILGMRYPQHSVVRVPIRERLNLTVRPGGEQAAYELCVQTVPAEHCPGSVMFYFETKTVRLLYTGDFRLSAESITVIERDRVRPNIVYLDSTFLSREYAFFPTRQTSMDRIVQICSRWLEGDRRNIVSLWPPASYGSEELFYQLASRLHQRIHVYASQREPYNHFAMLADIFTDDSVGARIHACRGKTLQHEVPCRKTREKAEFVLTIRPSARRWTNLRPEEPFSRQGGANLWYVCYSSHASSSELVDFVRSLQPEVQDIRFNVVENEEDRIRKEAYLRSLLVSGCEEGKKPTETEKEQMHCLPMGNFKAKAKLKLIARRDSDSDEENELFPKPMKMARRTGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P245</accession>
    <name>A0A182P245_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P245"/>
    <dbReference type="STRING" id="199890.A0A182P245"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000979-RA">
        <property type="protein sequence ID" value="AEPI000979-PA"/>
        <property type="gene ID" value="AEPI000979"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000979"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF69">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000979-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="72" mass="7990" checksum="2D2D8FC75E61AD99" modified="2016-09-07" version="1">MKRQGKSFDITYVEFLLAIDVTSSGTPEEKLKWAFRMYDVDGNGVIDIQEMTKIVQATGAVIAPAMQDSMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2B6</accession>
    <name>A0A182P2B6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2B6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001050-RA">
        <property type="protein sequence ID" value="AEPI001050-PA"/>
        <property type="gene ID" value="AEPI001050"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001050"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130697" evidence="1">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001050-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="103" mass="11714" checksum="148705459F0C166A" modified="2016-09-07" version="1">MNDKIFLILFSSLAILCEAIIVHDHYGKDHSANHQRRLLYGDNHVPVHQQKMSSSEETTRNANGMLNLHEVDAFGDDFVDFGAQTGPYGAFTWHANFPVEEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2H4</accession>
    <name>A0A182P2H4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptosomal-associated protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Synapse</location>
            <location evidence="6">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2H4"/>
    <dbReference type="STRING" id="199890.A0A182P2H4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001108-RA">
        <property type="protein sequence ID" value="AEPI001108-PA"/>
        <property type="gene ID" value="AEPI001108"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001108"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd15885">
        <property type="entry name" value="SNARE_SNAP25C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15889">
        <property type="entry name" value="SNARE_SNAP25N_23N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000007">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000018">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000928">
        <property type="entry name" value="SNAP-25_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF14">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00835">
        <property type="entry name" value="SNAP-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0771">Synaptosome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001108-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="212" mass="23540" checksum="5AA4A11C2AEEA96E" modified="2016-09-07" version="1">MPAPAPAENGAGVPKTELQELQIKQQQVVDESLDSTRRMLALCEESTEVGMRTIVMLDEQGEQLDRIEEGMDQINADMREAEKNLSGMEKCCGICVLPCNKSASFKEDDGTWKGNDDGKVVNNQPQRVMDDRNGLGPQAGYIGRITNDAREDEMEENMGQVNTMIGNLRNMALDMGSELENQNRQIDRINRKGDSNATRIAAANERAHDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2Z3</accession>
    <name>A0A182P2Z3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P2Z3"/>
    <dbReference type="STRING" id="199890.A0A182P2Z3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001280-RA">
        <property type="protein sequence ID" value="AEPI001280-PA"/>
        <property type="gene ID" value="AEPI001280"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001280"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000016">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000020">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001155">
        <property type="entry name" value="Transcriptional adapter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000170">
        <property type="entry name" value="Transcriptional adapter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056267">
        <property type="entry name" value="Ada2b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF63">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24533">
        <property type="entry name" value="Tri-helical_Ada2b_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="123"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="301"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="394"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="23">
        <location>
            <begin position="584"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="21">
        <location>
            <begin position="586"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="245"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="833"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="878"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="905"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="934"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001280-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1031" mass="115738" checksum="A7F9E1BA5873BE25" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P362</accession>
    <name>A0A182P362_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P362"/>
    <dbReference type="STRING" id="199890.A0A182P362"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001346-RA">
        <property type="protein sequence ID" value="AEPI001346-PA"/>
        <property type="gene ID" value="AEPI001346"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001346"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20617">
        <property type="entry name" value="CYP1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303:SF27">
        <property type="entry name" value="CYTOCHROME P450 307B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303">
        <property type="entry name" value="HEME-BINDING MONOOXYGENASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001346-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="531" mass="59998" checksum="DE62FDD7A949ADD2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3P0</accession>
    <name>A0A182P3P0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">REM-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3P0"/>
    <dbReference type="STRING" id="199890.A0A182P3P0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001525-RA">
        <property type="protein sequence ID" value="AEPI001525-PA"/>
        <property type="gene ID" value="AEPI001525"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001525"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11622">
        <property type="entry name" value="HR1_PKN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11623">
        <property type="entry name" value="HR1_PKN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000002">
        <property type="entry name" value="Putative serine/threonine-protein kinase N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037313">
        <property type="entry name" value="PKN_HR1_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="REM-1" evidence="4">
        <location>
            <begin position="52"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="4">
        <location>
            <begin position="145"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="4">
        <location>
            <begin position="239"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001525-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="293" mass="32992" checksum="666F780D7F83F57A" modified="2016-09-07" version="1">MALYITDYNNRYRKRRRSRVFSTCVSAAVVEKGDYIKHPVLYELSHKYGLPDNVSEHLLPDRLEEIKEAIRREIRKELKIKEGAEKLREVATDRRSLSDVASIVKKSNSKLAELKSELHELESQIILTQGNSVSNNGGHDPILSTVIPSGPELTANDKLLISLEKQLSIETKVKNGAENMIQSISSGHHGRDKKLLAEALQMLADSKAKIEYLRLKILKVRQNKLNSKVSEENGGESATAVKQAQELETSLDDRIEELRHRLRIEAAVVDGAKNVIRTLQSTKTIDKKALQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4G0</accession>
    <name>A0A182P4G0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182P4G0"/>
    <dbReference type="STRING" id="199890.A0A182P4G0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001796-RA">
        <property type="protein sequence ID" value="AEPI001796-PA"/>
        <property type="gene ID" value="AEPI001796"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001796"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000085">
        <property type="entry name" value="Glycogenin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="574"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="649"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001796-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="741" mass="82706" checksum="DB60ADFF26C76F6E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4W2</accession>
    <name>A0A182P4W2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4W2"/>
    <dbReference type="STRING" id="199890.A0A182P4W2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001949-RA">
        <property type="protein sequence ID" value="AEPI001949-PA"/>
        <property type="gene ID" value="AEPI001949"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001949"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001949-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="357" mass="40972" checksum="8130CB442035767F" modified="2016-09-07" version="1">MLIRNIEQEKQACMHVNWYELFQKNTIKSCIIPVPEDVLAYLRQDMLILPKECSNFTDVSTGEGFQTTHYNAFDDQFDGSDGEEDDANEQPAFPEFSQALTDAIRSLGGCAFLKSDWHCPKDAQWITLGQSLCVRDITDVYQLLKASSFCKEDFRERSEVNESGYHIVLKKWKDIHPGSEFRCFVRNRSLLAISPRHWPSYHEHIARERSDIVNDIVSLFKEKIKDTFPLKDYVFDVYRPGKDNVIIMDFSLYGKGHSDSLAFDYDQLDDEALVATIEEEDDPEFRYLPNDCGIQPIKRNVYGFPQDFRNFFQGAASSSNGDTAGEASAEGDSNNLVNRLIEQCNLQQLHDDNQDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P542</accession>
    <name>A0A182P542_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P542"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002029-RA">
        <property type="protein sequence ID" value="AEPI002029-PA"/>
        <property type="gene ID" value="AEPI002029"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002029"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF4">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="515"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="915"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1056"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1120"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="962"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1131"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002029-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1361" mass="147319" checksum="7D22EDD6F0E3F1A7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P552</accession>
    <name>A0A182P552_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatidylethanolamine-binding protein family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P552"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002040-RA">
        <property type="protein sequence ID" value="AEPI002040-PA"/>
        <property type="gene ID" value="AEPI002040"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002040"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001695">
        <property type="entry name" value="ATP-binding cassette sub-family G member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001858">
        <property type="entry name" value="Phosphatidylethanolamine-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF44">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01220">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="845"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="892"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="270"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002040-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1755" mass="195778" checksum="02E738C758E9EFB2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5A4</accession>
    <name>A0A182P5A4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol 4,5-bisphosphate 5-phosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182P5A4"/>
    <dbReference type="STRING" id="199890.A0A182P5A4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002092-RA">
        <property type="protein sequence ID" value="AEPI002092-PA"/>
        <property type="gene ID" value="AEPI002092"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002092"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000039">
        <property type="entry name" value="72 kDa inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053321">
        <property type="entry name" value="IPP-5-Phosphatase_Type_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47039">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47039:SF1">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="8">
        <location>
            <begin position="469"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002092-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="829" mass="90768" checksum="2181534F6CF85348" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P736</accession>
    <name>A0A182P736_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P736"/>
    <dbReference type="STRING" id="199890.A0A182P736"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002738-RA">
        <property type="protein sequence ID" value="AEPI002738-PA"/>
        <property type="gene ID" value="AEPI002738"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002738"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000242">
        <property type="term" value="C:pericentriolar material"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046600">
        <property type="term" value="P:negative regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042791">
        <property type="entry name" value="CDK5RAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46930">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46930:SF1">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="639"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="788"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1022"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1110"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="168"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="272"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="797"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1116"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002738-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1215" mass="137222" checksum="D3A8AB61D1786848" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P779</accession>
    <name>A0A182P779_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P779"/>
    <dbReference type="STRING" id="199890.A0A182P779"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002781-RA">
        <property type="protein sequence ID" value="AEPI002781-PA"/>
        <property type="gene ID" value="AEPI002781"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002781"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000177">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0222">Digestion</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131002" description="Peptidase S1 domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="26"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002781-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="256" mass="27443" checksum="0260EF9E411AB8F1" modified="2016-09-07" version="1">MVRVTVFIFTLLLGLAAANPTKGGRIVGGYDAVDGQFPHQVSLRRPPNFHFCGGSIIGPRWILSATHCTIGMAPSNVNVYVGSVKLATGGVYHRVMRIVNHPLYDSNTVENDISLLQTVIPIVFNEHTKPIGLASTNLVSATGATISGWGRSNTMDSGAAEVPDNMQYMTVNILTMEECRAERPDSGNIFDSVLCVSSPPGQGACSGDSGGPLTYDGELHGVASFVRVPCATDVSDVYERVYSHLSWIASVMLWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P790</accession>
    <name>A0A182P790_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P790"/>
    <dbReference type="STRING" id="199890.A0A182P790"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002792-RA">
        <property type="protein sequence ID" value="AEPI002792-PA"/>
        <property type="gene ID" value="AEPI002792"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002792"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531:SF0">
        <property type="entry name" value="GEO07735P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531">
        <property type="entry name" value="GEO07735P1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002792-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="137" mass="15608" checksum="3E5F0AFD3B09A63F" modified="2016-09-07" version="1">MGNPSLTYEILLYLNSFYFGMFATCELGMLTLKAVNLKYPDHILLREACILVALCLVETIRIILGRRGSLSDHGWQVILSVFLTIPCGMGVGYLLFYQLHRLRLEYILCALMLSLQAAELFFAILFVFTLCRPPSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P792</accession>
    <name>A0A182P792_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P792"/>
    <dbReference type="STRING" id="199890.A0A182P792"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002794-RA">
        <property type="protein sequence ID" value="AEPI002794-PA"/>
        <property type="gene ID" value="AEPI002794"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002794"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052458">
        <property type="entry name" value="PcG_PRC1-like_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46389">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46389:SF3">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002794-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="740" mass="81431" checksum="EE5A857CA244F591" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7G9</accession>
    <name>A0A182P7G9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7G9"/>
    <dbReference type="STRING" id="199890.A0A182P7G9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002871-RA">
        <property type="protein sequence ID" value="AEPI002871-PA"/>
        <property type="gene ID" value="AEPI002871"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002871"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130960" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="39"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="139"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002871-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="200" mass="21888" checksum="058E568794D1C0F9" modified="2016-09-07" version="1">MASIVGSGWQLPLVLLLVATCCLGAPADIFADNSLCPAPRCVTYQEINTLWAVPDPAYFLQCRPSPLGDWTLQQMPCAPATLFSFRQQVCVRPEYWEGCAGTPTVTSPTTPIPSSTDANLSTDGSLSTTVTIPPGIGDSFCQQAKCVTYEEINTLWNDEQPNYFCQCRPIGGAWAPIRMPCAPSTIFSFRHQVCVWQEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7H5</accession>
    <name>A0A182P7H5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP-ribosylation factor-like protein 6</fullName>
            <ecNumber evidence="8">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">HECT domain and RCC1-like domain-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">HECT-type E3 ubiquitin transferase HERC2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="35 36">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="36">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="35">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Cilium membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="8"/>
    <dbReference type="STRING" id="199890.A0A182P7H5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002877-RA">
        <property type="protein sequence ID" value="AEPI002877-PA"/>
        <property type="gene ID" value="AEPI002877"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002877"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08664">
        <property type="entry name" value="APC10-HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04157">
        <property type="entry name" value="Arl6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14402">
        <property type="entry name" value="UBA_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000457">
        <property type="entry name" value="ADP-ribosylation factor-like protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000015">
        <property type="entry name" value="E3 ubiquitin-protein ligase HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase HERC2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000006">
        <property type="entry name" value="E3 ubiquitin-protein ligase HERC2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000074">
        <property type="entry name" value="E3 ubiquitin-protein ligase HERC2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HERC2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase HERC2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000131">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000006">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041839">
        <property type="entry name" value="Arl6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021097">
        <property type="entry name" value="CPH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037976">
        <property type="entry name" value="HERC2_APC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11515">
        <property type="entry name" value="Cul7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-0966">Cell projection</keyword>
    <keyword evidence="18" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="19 26" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="23" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="27" id="KW-0460">Magnesium</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0519">Myristate</keyword>
    <keyword evidence="16 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="17 28" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="596"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="648"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="702"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="753"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="32">
        <location>
            <begin position="1255"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="34">
        <location>
            <begin position="2069"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="domain" description="DOC" evidence="33">
        <location>
            <begin position="2959"/>
            <end position="3139"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="3162"/>
            <end position="3213"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="3214"/>
            <end position="3267"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="3268"/>
            <end position="3319"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="3320"/>
            <end position="3371"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="3374"/>
            <end position="3425"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="3426"/>
            <end position="3477"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="3478"/>
            <end position="3529"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="4193"/>
            <end position="4244"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="4245"/>
            <end position="4298"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="4299"/>
            <end position="4350"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="4351"/>
            <end position="4402"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="4405"/>
            <end position="4456"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="4457"/>
            <end position="4508"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="29">
        <location>
            <begin position="4509"/>
            <end position="4560"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="31">
        <location>
            <begin position="4689"/>
            <end position="5019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1400"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1734"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="2538"/>
            <end position="2573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="2663"/>
            <end position="2688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
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    <sequence length="5265" mass="573487" checksum="C621AEDA567D0F50" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7R8</accession>
    <name>A0A182P7R8_9DIPT</name>
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        <recommendedName>
            <fullName evidence="14">Chloride channel protein</fullName>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18">Epiroticus2</strain>
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        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <strain evidence="17">Epiroticus2</strain>
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            <location evidence="1 14">Membrane</location>
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        <text evidence="14">Belongs to the chloride channel (TC 2.A.49) family.</text>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002971-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1108" mass="122909" checksum="B5F46C098F74CE68" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8S7</accession>
    <name>A0A182P8S7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gcp-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P8S7"/>
    <dbReference type="STRING" id="199890.A0A182P8S7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003331-RA">
        <property type="protein sequence ID" value="AEPI003331-PA"/>
        <property type="gene ID" value="AEPI003331"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003331"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003331-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9014" checksum="C7793E31DBDF3D70" modified="2016-09-07" version="1">MAAQFGYSTYRPPKKLCTDNGTMIAWNGVEKLLANDMAEVTKDYAQVDISGKCPIGESLIEDVKQANIACKWAKVDVFAEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9P4</accession>
    <name>A0A182P9P4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P9P4"/>
    <dbReference type="STRING" id="199890.A0A182P9P4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003649-RA">
        <property type="protein sequence ID" value="AEPI003649-PA"/>
        <property type="gene ID" value="AEPI003649"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003649"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001818">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF176">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003649-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="280" mass="30405" checksum="F8EE025485E0EFA3" modified="2016-09-07" version="1">MPGHDGNTKVFECEVCGKKLKSKSNYTNHRKMHSRKEHNAPPKAVSENRSISEQKRVYLCNICGHNCGSSSNLGVHLRRHNGQSVCECTVCGKGFPRRSDMVMHMRKHTGEKPFTCPTCTRGFSRLDKLRIHIRTHTGEKPYKCPCGRAYAQSGGLQRGLNIIPESYGTVEGVPSAGLHLNADSLVDIMFPGSWNSCMSTPHFQHHERSADGGYEGSSSYGVWDASGRTAVIAMSPSDDSFLTCGLRLPLALVRPSASSGSTTSPGEPEDGGSLLTEPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAB7</accession>
    <name>A0A182PAB7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAB7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003871-RA">
        <property type="protein sequence ID" value="AEPI003871-PA"/>
        <property type="gene ID" value="AEPI003871"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003871"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003871-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="94" mass="10063" checksum="4641768D46640D0C" modified="2016-09-07" version="1">MATDGYTDAMDAGPRSSNTIIDNTVIIIVSVGGVAHSLLLVAVIAIRGVKQLLPCLTSSPMICLITVRSRVDGASSSYGREEYLSMSEVRMIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAL7</accession>
    <name>A0A182PAL7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAL7"/>
    <dbReference type="STRING" id="199890.A0A182PAL7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003972-RA">
        <property type="protein sequence ID" value="AEPI003972-PA"/>
        <property type="gene ID" value="AEPI003972"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003972"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19597">
        <property type="entry name" value="serpin28D-like_insects"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000035">
        <property type="entry name" value="Serine protease inhibitor (serpin) 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF342">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR 28DC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131089" description="Serpin domain-containing protein" evidence="4">
        <location>
            <begin position="32"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="59"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003972-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="477" mass="52828" checksum="9DB2AB5A938E6C80" modified="2016-09-07" version="1">MPYGAIASAKVPFRLLLLAAALLLGGAEVNTQNNSNGLSKAVSEQLVAAINELARTLGQQLGGAAGSNSSKTELFSPVSIGSMMFLLLRAANRDTRTELLTVMQLDQFRKPGSGNIPKNVGRLLKEFTRDIGGKGILGQLPSWHTSGSCYPSVNGSDYDEENDDNFLDEPVQPNVVQLANGLFLQSGLINGTNFVRLAKELYQAQIEQVNFRQQPGAARVTINRWVNESTRGRIREILTDDPDTGTQLIVANALYFKGTWETFFNEPQFSRPQPFFPDGEEQPSVMVPTMFAGGCFPYHSSPELDARIMAFPYRNRTTSMYIILPNDSNRAKLRQLQRALTSAELDRLIGQMRLQKAIVQFPRMHVSNTYDLKQALQRLGLRKLFDKSKNNLKIVSSPSSKSEAGGARNPKLYISEMVHKIDLEINERGTEGGAVTITAMERSLPPVSFRVRGPFLLAIRHDPTKMLLFYGAVFDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAQ6</accession>
    <name>A0A182PAQ6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAQ6"/>
    <dbReference type="STRING" id="199890.A0A182PAQ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004011-RA">
        <property type="protein sequence ID" value="AEPI004011-PA"/>
        <property type="gene ID" value="AEPI004011"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004011"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000080">
        <property type="entry name" value="RNA-binding protein 39 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000090">
        <property type="entry name" value="RNA-binding protein 39 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="199"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004011-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="554" mass="62563" checksum="617C193BD1361483" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAS4</accession>
    <name>A0A182PAS4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS7m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S7, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAS4"/>
    <dbReference type="STRING" id="199890.A0A182PAS4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004029-RA">
        <property type="protein sequence ID" value="AEPI004029-PA"/>
        <property type="gene ID" value="AEPI004029"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004029"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044391">
        <property type="term" value="C:ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14870">
        <property type="entry name" value="uS7_Mitochondria_Mammalian"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000004">
        <property type="entry name" value="28S ribosomal protein S7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
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        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041309"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004029-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="227" mass="26496" checksum="4EA98DEF58BBE554" modified="2016-09-07" version="1">MLRRLVCTVWQRHAAAQCIVPVARMSQYGPHFIEPIVSKEKIEELQKTGDLSKISHVPVKAALSNQNCSVFYDPLVAQFTNYVMKQGNKALARELVEKGFENIKRLQLERYHLSESEEEKAKLELNPRKLLHQAVENCRPLLQLTPIKRGGVRYQVPVPITEKRSYFLAMKWLLEAIREKERTVHFPEKMAWEILDAAANQGKVVKRKHELHRQCEANRAYAHYRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
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        <property type="gene ID" value="AEPI004289"/>
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    </dbReference>
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        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="eIF4E-T"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12269:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="141"/>
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    </feature>
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        </location>
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        <location>
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            <end position="479"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004289-PA"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="551" mass="62135" checksum="A0175059A39906FD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCC5</accession>
    <name>A0A182PCC5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCC5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004580-RA">
        <property type="protein sequence ID" value="AEPI004580-PA"/>
        <property type="gene ID" value="AEPI004580"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004580"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCD0</accession>
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            <fullName evidence="12">Peptidyl-prolyl cis-trans isomerase</fullName>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A182PCD0"/>
    <dbReference type="STRING" id="199890.A0A182PCD0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004585-RA">
        <property type="protein sequence ID" value="AEPI004585-PA"/>
        <property type="gene ID" value="AEPI004585"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004585"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="14">
        <location>
            <begin position="37"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004585-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="133" mass="13996" checksum="8694F939EBEBA6EF" modified="2016-09-07" version="1">MPPKKDAKGGAKAAPAKGGGKKGGGAEEGAAKEKKGGTAVKVRHILCEKQGKIMEALEKLKEGQAFNVVATNYSEDKARQGGDLGWQIRGAMVGPFQDAAFALPISTTNAPKYTDPPIKTKFGYHIIMVEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCD7</accession>
    <name>A0A182PCD7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCD7"/>
    <dbReference type="STRING" id="199890.A0A182PCD7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004592-RA">
        <property type="protein sequence ID" value="AEPI004592-PA"/>
        <property type="gene ID" value="AEPI004592"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004592"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004592-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="359" mass="40147" checksum="872D014AC2381B5D" modified="2016-09-07" version="1">MKFEGDGGHGDDTKRWRRGSIPCVPEPDPRYGARFPWPFAWTSGTRQPPLNPGDMANLHERINHLRPRWFEGFQLNVTKGCGVNRTLGASWNLSHVTPSGFRFGGHFHRRCSDTVLTTPLVAFDVNPTTLCSNLLLLYRPVRAVGLELSLQLRPGAPPFVDEVSLQYTGLSRTSTVRCSTPGTLDSYRVGVDHLVSLNDRLCFGVELLCECYRGVHNTNVAFAGRYNRETSTLAATVSPEAFDLSYWQKVSGTLQLGSSIIVNQRQNRALGSVCYRLEHEDTVIRGSFDSDWTVGFTYSRKLTPAAFTACLSLLFCVPKNTFQCGFRIDLDSNLLDSVTISGDIWLSWKQIHPSKMVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCG5</accession>
    <name>A0A182PCG5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCG5"/>
    <dbReference type="STRING" id="199890.A0A182PCG5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004620-RA">
        <property type="protein sequence ID" value="AEPI004620-PA"/>
        <property type="gene ID" value="AEPI004620"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004620"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="351"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="707"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004620-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="760" mass="84380" checksum="6ED52DE59931CC2D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCN2</accession>
    <name>A0A182PCN2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCN2"/>
    <dbReference type="STRING" id="199890.A0A182PCN2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004687-RA">
        <property type="protein sequence ID" value="AEPI004687-PA"/>
        <property type="gene ID" value="AEPI004687"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004687"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004687-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="238" mass="25493" checksum="01ED6FC6A87E6D48" modified="2016-09-07" version="1">MMSQHLNSMLEHLKMGSLMSKGGSSAKQQQQQQQQQQQQQQVVPSASANGSVAGASGAPNGSCANNNLHCNHHSSHSNNNNNTSSINHNNNCHNGGPLVAGKMAPGETTLLVERREGGEGRESSKGNHIGEVERRGYDVSRKRCSISVQQHGADGSTVRTNYRELSPASLRIHRKSSHDIRNTLLGPDGEVLHLHDPSGKGGDGMGKMPAVVKPIKLKSIVTKAESYDTMHGKASDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCQ3</accession>
    <name>A0A182PCQ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 55 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCQ3"/>
    <dbReference type="STRING" id="199890.A0A182PCQ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004708-RA">
        <property type="protein sequence ID" value="AEPI004708-PA"/>
        <property type="gene ID" value="AEPI004708"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004708"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="245"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004708-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="487" mass="54064" checksum="207B920AFBDE9B0C" modified="2016-09-07" version="1">RNFQSPYYRDSSDSEGDDDFELNPYLLDVNADDPGPELVEYLSDGDEVAAAGTVEMRNGEQSNDDSDDDTYVEDAADNQMSDSSYDSDLNASDSDEGSEAAAEGSNKNAAAKPTTSTGEDTTQPTRRVIEDYDEEEEDDEVIKAIISEIKKPRSKPPDIQVEDFVVDLSFHPTEDILAIGTSVGDVLMYKYSNEANVLAATHELHTKAIRCAEFSRDGKTLITTGRERSIVVMDSETGKFKRFWEAAHDEPVYSMSVLGEHLFATGDDDGEVKLWDVRERNAVFSLRPVEDFISSILANQVQQKYLLVTSGDGLLTTINIAQRKMHVQSEPYEEELNCMGTFKRESKLVVGTSKGNYYTFNWGQFAYHCDAFTGPPASASRMVPITEQIAVMAGEDGILRAMHMVPGRVLGIVGQHAMAVDTLDISGSGELIASSSHDNDVRFWNIKYFEDFDGIKYNSKPDKRTLKHNLPSSQRTNARDFFAGLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCZ8</accession>
    <name>A0A182PCZ8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH OST-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCZ8"/>
    <dbReference type="STRING" id="199890.A0A182PCZ8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004803-RA">
        <property type="protein sequence ID" value="AEPI004803-PA"/>
        <property type="gene ID" value="AEPI004803"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004803"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09972">
        <property type="entry name" value="LOTUS_TDRD_OSKAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004803-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="200" mass="23079" checksum="6C3D416696AE1F20" modified="2016-09-07" version="1">METNAELVKLKPIIRGLVMSHPNHCMSLAELERDFRNTEGYEIPHERLGFSSVYHLLCYIKDTVMVCSDNGRTIVKYVSTSAVAHVERLLRSTPKPRKGRHMHNNLLEKQILLQKKLMVQKKILLLMKVLLQKKSLLQKKSQLQKKSQLQKKSLMQKKALLQKKSLLPQKNLHLNIRKNLANMLMAASHRPNRTPTFGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD12</accession>
    <name>A0A182PD12_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PD12"/>
    <dbReference type="STRING" id="199890.A0A182PD12"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004817-RA">
        <property type="protein sequence ID" value="AEPI004817-PA"/>
        <property type="gene ID" value="AEPI004817"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004817"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02991">
        <property type="entry name" value="UAS_ETEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16120">
        <property type="entry name" value="UBX_UBXN3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="355"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004817-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="439" mass="50594" checksum="F44463A9FC296660" modified="2016-09-07" version="1">MDNDGMSNEQTEKVLQFQDITGLDDMNVCRDILIRHQWDLEIAFQEHLNIREGRPSAYATESRAPAVINDRFLQHVFSSARTSPPRDSGGFVGVLGYMFNSLVNFWYNAFSSILSMVLGFWRDQESIPADPLGDVLKFIQTYNEKYPEHPVFYQGTYSQALNDAKNELRFLLVYLHSEPTSEAVAFCRGALSDPQVIEYVNRRMLFWGCDMASHEGKRVATTISVRTHPTLIIIGMRANKMIIMGRLEGDCTAEELIRRMDTVVNDNEVWLNQARQDRLERDLTQTLRQQQDEAYQRSLQADQEKQRRKQQEREELMRIQAAIEAEQLAEQQRKEDIERLKLDLAEQVPSEPEAGAPDTISIVFKLPSGLRLERRFRNTDTMRDIYNFIFCHPDAPDSFEITTNFPKRVIECSGDKPGETLLLAGLKNREVLFVADLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDC4</accession>
    <name>A0A182PDC4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PMT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDC4"/>
    <dbReference type="STRING" id="199890.A0A182PDC4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004929-RA">
        <property type="protein sequence ID" value="AEPI004929-PA"/>
        <property type="gene ID" value="AEPI004929"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004929"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052384">
        <property type="entry name" value="TMTC_O-mannosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase RgtA/B/C/D-like" evidence="1">
        <location>
            <begin position="69"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004929-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="224" mass="24058" checksum="866BA8FBD80499D8" modified="2016-09-07" version="1">MHERKSRFLQAVWIPPSLVGLGRAILGNPDVLGTGGWSQLLQNDFWGTPLVDSGSHGSYRPLCVASFKLNYLVDGFKPFGYHLVNVLLHSLATGLVVKLARHILPAGRSGVAITGLLFAAHPIHTEAVAGVVGRADLTGCIFYLLALLAYIRHVRWRQWGDGRQWLALAATVLLAGAAILCKETAVTALVVCAIYDIIKGYAGSRDKVRLSSAHTPGATVPRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDF0</accession>
    <name>A0A182PDF0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDF0"/>
    <dbReference type="STRING" id="199890.A0A182PDF0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004955-RA">
        <property type="protein sequence ID" value="AEPI004955-PA"/>
        <property type="gene ID" value="AEPI004955"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004955"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058599">
        <property type="entry name" value="PHAT_Smg/ZCCHC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042344">
        <property type="entry name" value="ZCCHC14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16195">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16195:SF16">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26034">
        <property type="entry name" value="PHAT_SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="383"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004955-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="808" mass="89067" checksum="BF74AC3CAE281355" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE03</accession>
    <name>A0A182PE03_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PE03"/>
    <dbReference type="STRING" id="199890.A0A182PE03"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005158-RA">
        <property type="protein sequence ID" value="AEPI005158-PA"/>
        <property type="gene ID" value="AEPI005158"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005158"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005158-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="111" mass="13356" checksum="9297580356002307" modified="2016-09-07" version="1">MFKYKELTKLTTTYARRMNYLSNRIFGEVARPTNSQSMKVVKMFSEEPVNKRDYVVNWYPRHVETHLLAMKLREYGLFRDEHQDFKEEMKRLRALRGKAPPKKGEGKRAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE15</accession>
    <name>A0A182PE15_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TMEM104 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PE15"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005170-RA">
        <property type="protein sequence ID" value="AEPI005170-PA"/>
        <property type="gene ID" value="AEPI005170"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005170"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="149"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005170-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="518" mass="57444" checksum="FF10E8B93510E59B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEF8</accession>
    <name>A0A182PEF8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. Maf subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEF8"/>
    <dbReference type="STRING" id="199890.A0A182PEF8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005313-RA">
        <property type="protein sequence ID" value="AEPI005313-PA"/>
        <property type="gene ID" value="AEPI005313"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005313"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14718">
        <property type="entry name" value="bZIP_Maf_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000011">
        <property type="entry name" value="Transcription factor MafG, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF44">
        <property type="entry name" value="TRAFFIC JAM, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="372"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="463"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005313-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="588" mass="62717" checksum="87CA058F4948765E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFI0</accession>
    <name>A0A182PFI0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PFI0"/>
    <dbReference type="STRING" id="199890.A0A182PFI0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005687-RA">
        <property type="protein sequence ID" value="AEPI005687-PA"/>
        <property type="gene ID" value="AEPI005687"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005687"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005687-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="86" mass="9408" checksum="792F1E6610C5A99F" modified="2016-09-07" version="1">VSKEEVAKIVQGFDKTELLTSGGVTLAGQRYIYLSGTDRVIRAKLGKTGVHCMKTQQVSIYEEPVQPQQAASIVEKLGDYLITCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFK3</accession>
    <name>A0A182PFK3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PFK3"/>
    <dbReference type="STRING" id="199890.A0A182PFK3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005710-RA">
        <property type="protein sequence ID" value="AEPI005710-PA"/>
        <property type="gene ID" value="AEPI005710"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005710"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000027">
        <property type="entry name" value="Eto/mtg8/nervy, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013289">
        <property type="entry name" value="CBFA2T1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014896">
        <property type="entry name" value="NHR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10379">
        <property type="entry name" value="MTG8 ETO EIGHT TWENTY ONE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10379:SF14">
        <property type="entry name" value="NERVY, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08788">
        <property type="entry name" value="NHR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01875">
        <property type="entry name" value="ETOFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005710-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="417" mass="43660" checksum="6B40F0E4E2440202" modified="2016-09-07" version="1">MLVFGKTSSQYVRSNESSVMEYVQNLADTAEIFLPHEGTFASSVTAAAAAAAAAAAAVASGAASGGPAAGATVNGLGLKRRASDNLYDTHSSGPPEWGEYVLPPTKRPHPSLLLASGAAQLYPGHPALFEYQNGGLHPHSDGLHSIHRDDRDLRAGSTESHRPPRIPPGGGSGGGGAGGGGSGSGSTGNGTLGSGSISGGSIGGGASGEEEWKNIHTMLTCISAMVEKTKRAISILQQRGIENSHARDHQDSSMADIKRQTEEKISEFRRTAEESVNQVKRQAVMEIQRAVAAAEARTLEMIAQERLKMEKMYADIHRSSSAADDAEPPITTGSQNACWNCGRKANETCSGCNLARYCGSFCQHKDWDQHHQVCGTSRAENSFQKHTASSRASIASRSTTPQQQSSSTSNGTAATAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGE6</accession>
    <name>A0A182PGE6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 28 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex, a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ESCRT-I complex (endosomal sorting complex required for transport I).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGE6"/>
    <dbReference type="STRING" id="199890.A0A182PGE6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006005-RA">
        <property type="protein sequence ID" value="AEPI006005-PA"/>
        <property type="gene ID" value="AEPI006005"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006005"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 7 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="9">
        <location>
            <begin position="112"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00056039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006005-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="210" mass="24433" checksum="70E8CF1C514E7557" modified="2016-09-07" version="1">MQDNRPELYEEVKLYRQAREREKYDNMADLFALVSTLQNLEKAYIRDCITPQEYTAACSKLLVQYKVAFKIVQGDEFPTIDSFVKKFRLDCPAALERIREDRPITIRDDKGNTSKCIADIVSMFITLMDKLRLEIRAMDDLQPELRDLLDTMNRLSLIPDNFEGKEKVSNWLATLNTMQASDDLTEAQVRQLLFDLESSYSAFNNLLHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGN4</accession>
    <name>A0A182PGN4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGN4"/>
    <dbReference type="STRING" id="199890.A0A182PGN4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006093-RA">
        <property type="protein sequence ID" value="AEPI006093-PA"/>
        <property type="gene ID" value="AEPI006093"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006093"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000018">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006093-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="248" mass="27524" checksum="96FFFB83BD68BC73" modified="2016-09-07" version="1">MIRKVMAEVDVKLGIRQTLQKIEETYSKRQTLSNAPKPLLIAVSKTKPVDLILDAYSVGQRDFGENYVQELVEKANDAKILEHCQDIRWHFIGHLQSNKINKLAEGLNKAWEKVKADNADKKQKLNVLVQINTSGEDGMSQTKKNGVQPEDAVGLFRYVLDKCPNLNCEGVMTIGRFGHDYITGPNPDFGTLMKCHQGICSTFERDPAELQVSMGMSDDFVQAIEAGSTIVRVGSSIFGARAKKPTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGW8</accession>
    <name>A0A182PGW8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGW8"/>
    <dbReference type="STRING" id="199890.A0A182PGW8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006177-RA">
        <property type="protein sequence ID" value="AEPI006177-PA"/>
        <property type="gene ID" value="AEPI006177"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006177"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:hydroxypyruvate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="60"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="157"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006177-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="367" mass="40861" checksum="3D9E4783B158B9EB" modified="2016-09-07" version="1">MNPVFRQLSAVLSSGSLRRGTIRLANNLRPQRTVFQSPHRTFCCFEMKPKVYVTRNDYARIGLDLLREECDISLWDEAYPVPRDEFLKNVAGKDAIYCSLNDRIDKELLDQAGPNLKVISTISVGYDHIDVKECKQRGIRIGYTPDVLTDATAELTVALLLATARRMLEANKQVHTGGWKSWSPMWMCGKSVKNSVVGIFGFGRIGQEVAKRLVPFKPSRIQFTSRTDKFLTAEDLNVTQVPFDELVETSDFLIIACSYNVETANLFNDAVFSRMKQSAILINTSRGGVVEQHDLIHALRAGKIQAAGLDVTTPEPLPLDNPLLTLPNVVVLPHIGSADIETRIEMSRITACNILAGLKGIKMLSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGY8</accession>
    <name>A0A182PGY8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
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    <sequence length="415" mass="46197" checksum="960C359FD7ECC652" modified="2016-09-07" version="1">MIFPFFKGQFSRPLLTFAAVATITIMVTGIVGNLLTIVALLRCPKVRNVAAAFIISLCVADCLFCIIVLPFNAMRFIQGTWNHGETLCTLITFMQYGSVGVSLLCITMISINRYIMIAHYSIYPKVYKTSWIMVMIVSCWLFSYGFQLPTLFGVWGKFGYNHQLGTCSILPDDEGRSSKTAMFIIAFIIPCMIIVICYSRIFCVVHKSDKRMKNHSKSQCNIPNNLRSTVDPASPLSAGSSGSANNNSISYTASSSAVKVAGARSAADTRDAKARRNEWRITKMVLAIFLSFVMCYLPITISKIVDKNVSVPVLHIIGYIMLYLSACINPIIYVIMNKQYRQAYKTVIFCKPSRLLGFTHGGSSVGEKWKDIGYSYNHSRTMVSQVSIAEPESPPSSRLRQDSPHPQHLVAIQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH14</accession>
    <name>A0A182PH14_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">Epiroticus2</strain>
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    </reference>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
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        <subcellularLocation>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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    </feature>
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        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006223-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1246" mass="132799" checksum="2EB5B8B7464824D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH77</accession>
    <name>A0A182PH77_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PH77"/>
    <dbReference type="STRING" id="199890.A0A182PH77"/>
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        <property type="protein sequence ID" value="AEPI006286-PA"/>
        <property type="gene ID" value="AEPI006286"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006286"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell surface receptor signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF32">
        <property type="entry name" value="DIURETIC HORMONE 31 RECEPTOR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006286-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="374" mass="41297" checksum="B22C95989906BBCD" modified="2016-09-07" version="1">MNLFVSFACNNSLWLLWYRLVLTDLDLLQESGAGCITLHLVLHYFLLTNYSWMLCEGFYLHTVLVSAFVSEKKLLKWLLALGWGSPAFFIVLYGFLRGYASPPNDTIECWMNDSSFNKVFVGPVCISMLLNLVFLFNIMRVLLLKLKAPAGPQGAGPSRTILQAFRATLLLVPLLGLQYILTPFRPGHGHPYERTYETMLACTSSFQGLFVAVLFCFLNGEVIAQVKRKWRTVFLRTRANSYTATQVSVSTLSGPFARSLLLPASSGTEPSDLPTSTVSRLNHHRTTDIDPPTVTPTTTAPTAVDTAAGTTPAQRVHFRPELVTDVGEEGKGAFAETVATTNGHHTHRQPGVNGFHAAKDDFPDDTEPPADEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI96</accession>
    <name>A0A182PI96_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PI96"/>
    <dbReference type="STRING" id="199890.A0A182PI96"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006658-RA">
        <property type="protein sequence ID" value="AEPI006658-PA"/>
        <property type="gene ID" value="AEPI006658"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006658"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF4">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006658-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="687" mass="78010" checksum="E79D3C5D9F973AFE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI97</accession>
    <name>A0A182PI97_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PI97"/>
    <dbReference type="STRING" id="199890.A0A182PI97"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006659-RA">
        <property type="protein sequence ID" value="AEPI006659-PA"/>
        <property type="gene ID" value="AEPI006659"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006659"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131419" evidence="2">
        <location>
            <begin position="25"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="151"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006659-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="363" mass="41363" checksum="212F350FF6E703C4" modified="2016-09-07" version="1">MRSHVLSVALCWSWTLLFVLVAGSNETATVSAPQTVDTSSSGYGFEMIMAKLDYLQYKLLEMDFVMKEHSEGIAQNQAHLEKVFGSMLWAISRLDQAVGNNLTALQAQSWRILSRQTVCANHEQMRNEIFSLAPKQGLAPNARTLFDLQGMRHKGPFESCRDEPSKMSGKYLLRAGNDVEPFPAYCEQTKFGGGWLVIQHRFKGALDFFRNWTEYRDGFGSIDQEFWIGLERLHQLTSAKPYQLLIEVEDFAGDYRYARYKEFEIGSEAEMYSLKKLGAYSGTGGDSLTYHKGHKFTTMDRDNDGAPTNCAVTCEGAWWYNNCHHSNLNGRFMNAVDVKSISWYHFKSSHLGMAYTRMMIKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIF5</accession>
    <name>A0A182PIF5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-related modifier 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIF5"/>
    <dbReference type="STRING" id="199890.A0A182PIF5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006717-RA">
        <property type="protein sequence ID" value="AEPI006717-PA"/>
        <property type="gene ID" value="AEPI006717"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006717"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006717-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="101" mass="11284" checksum="6BA67F6AAB30EFD5" modified="2016-09-07" version="1">MFLFSPGFLFSPSGGAETLFGGVKEHIVPLDGSKIVLLEEMLRWLRDHLLTGDVNLFLQENTVRPGILVMINDTDWDLMGETEYILQPGDHILFISTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIM3</accession>
    <name>A0A182PIM3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NALF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIM3"/>
    <dbReference type="STRING" id="199890.A0A182PIM3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006785-RA">
        <property type="protein sequence ID" value="AEPI006785-PA"/>
        <property type="gene ID" value="AEPI006785"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006785"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015275">
        <property type="term" value="F:stretch-activated, monoatomic cation-selective, calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055288">
        <property type="entry name" value="NALCN_aux_factor_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15819:SF11">
        <property type="entry name" value="MID1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15819">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN FAM155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131498" evidence="8">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006785-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="78" mass="8079" checksum="A4F47A325A3F824C" modified="2016-09-07" version="1">MRPGPGLVVMALAFISGARRGTGQQSSSASQSGKLGKVGEDNTEEGGALTRINPWLSACDLEQPNSAPDLQVSTKLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIX8</accession>
    <name>A0A182PIX8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIX8"/>
    <dbReference type="SMR" id="A0A182PIX8"/>
    <dbReference type="STRING" id="199890.A0A182PIX8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006891-RA">
        <property type="protein sequence ID" value="AEPI006891-PA"/>
        <property type="gene ID" value="AEPI006891"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006891"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF45">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 83A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00485">
        <property type="entry name" value="MEALWORMBTLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006891-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="144" mass="16792" checksum="2BDF3B45969E2D0B" modified="2017-10-25" version="2">MYIPYGWCKGGGECVTTDRPALRRDAEYPPPRILAFVKPLRQQCIRETGVSVEALERFSDADIFEDDQALKCYMQCMFRLSNVTDDRGELHLGKMFEFVSVEFEDITLRMGARCTKPKGKDLCERAFWFHKCWKTSDPTHYYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJV3</accession>
    <name>A0A182PJV3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJV3"/>
    <dbReference type="STRING" id="199890.A0A182PJV3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007219-RA">
        <property type="protein sequence ID" value="AEPI007219-PA"/>
        <property type="gene ID" value="AEPI007219"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007219"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09414">
        <property type="entry name" value="LIM1_LIMPETin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09830">
        <property type="entry name" value="PET_LIMPETin_LIM-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000093">
        <property type="entry name" value="prickle-like protein 4 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF37">
        <property type="entry name" value="PROTEIN ESPINAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="7">
        <location>
            <begin position="78"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007219-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="31272" checksum="55A81D120706B6B1" modified="2016-09-07" version="1">MLDLQRHADCPLWDALASPVVPWPGMRYACVKVLHAYCKVFNKQELYDLIVRKTCQECKCPRETHAVYHEQLTTVRERLGFKHDTNTSRVDPRQMGYTWVPPGILTSAKIQRYFDVIPPEKVPKIGTQGERFRDKQLVYQLPKQDLALDYCKHVEEQNRGSYEDFVAARNEIALDIGYVKDTPQATKCTGCSDTLNQGEMAVTAPKFREQTLWHPRCFKCTTCDELLVDLTYCVHDDQIYCERHYAEMLKPRCSACDEVGDATSLPTRPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJV4</accession>
    <name>A0A182PJV4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJV4"/>
    <dbReference type="STRING" id="199890.A0A182PJV4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007220-RA">
        <property type="protein sequence ID" value="AEPI007220-PA"/>
        <property type="gene ID" value="AEPI007220"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007220"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131407" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="798"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="848"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="961"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="848"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="862"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="885"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007220-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1019" mass="110966" checksum="10AAC556B0A44475" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJV6</accession>
    <name>A0A182PJV6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJV6"/>
    <dbReference type="STRING" id="199890.A0A182PJV6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007222-RA">
        <property type="protein sequence ID" value="AEPI007222-PA"/>
        <property type="gene ID" value="AEPI007222"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007222"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007222-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="87" mass="9489" checksum="16DDE834927C775E" modified="2016-09-07" version="1">MAMDILSSDFDSRLRLKTKTVGGERIKRAKDNNEDIAILSMFLPGATAAKEQEKFRCHLGMDCRVGDCRDTTPGTSSVHPQAVSASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKL3</accession>
    <name>A0A182PKL3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit 6B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKL3"/>
    <dbReference type="STRING" id="199890.A0A182PKL3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007480-RA">
        <property type="protein sequence ID" value="AEPI007480-PA"/>
        <property type="gene ID" value="AEPI007480"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007480"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="192"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007480-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="412" mass="46789" checksum="094EC3DA9C05FF59" modified="2016-09-07" version="1">MIDAEMVIPDKDESDTRTMKDAVNPLEEALEEDLYIKYKKLQKMLEFLEVQEEYIKDEQRNLKKEYLHAQEEVKRIQSVPLVIGQFLEAVDQNTGIVGSTTGSNYYVRILSTIDRELLKPSASVALHKHSNALVDVLPPEADSSISMLNADEKPDVQYSDIGGMDMQKQEIREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITAKMNLSEDVDLEDFVARPDKISGADINAICQEAGMHAVRENRYIVLAKDFEKGYKNNIKKDETEHEFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKS7</accession>
    <name>A0A182PKS7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytospin-A family.</text>
    </comment>
    <dbReference type="EnsemblMetazoa" id="AEPI007544-RA">
        <property type="protein sequence ID" value="AEPI007544-PA"/>
        <property type="gene ID" value="AEPI007544"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007544"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21199">
        <property type="entry name" value="CH_CYTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000020">
        <property type="entry name" value="Cytospin-A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF69">
        <property type="entry name" value="FI18193P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="866"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="929"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="965"/>
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        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="2057"/>
            <end position="2162"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
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    <feature type="region of interest" description="Disordered" evidence="4">
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    <feature type="region of interest" description="Disordered" evidence="4">
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="777"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
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    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="1520"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        <location>
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            <end position="288"/>
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    <feature type="coiled-coil region" evidence="3">
        <location>
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    <feature type="coiled-coil region" evidence="3">
        <location>
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    <feature type="coiled-coil region" evidence="3">
        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="95"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="113"/>
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            <begin position="124"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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            <begin position="147"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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            <begin position="466"/>
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        <location>
            <begin position="711"/>
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        <location>
            <begin position="747"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2021"/>
            <end position="2038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007544-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2163" mass="238816" checksum="2712EA58706903F5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKV4</accession>
    <name>A0A182PKV4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
            <orientation evidence="1 14">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKV4"/>
    <dbReference type="STRING" id="199890.A0A182PKV4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007571-RA">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
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    <keyword evidence="7 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007571-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="150" mass="17713" checksum="EA936237B1BD9D21" modified="2016-09-07" version="1">MSSPAKLQDLPPKGGYQNIPFKRVPAKTYFKGWQMIAGYAGISTVGLFLYWLNVKENHRNEVEMRSARNVIYPLLLAERDREYLKQLRRNRDEEAELMKNVEGWEVGTWYGEPVFKTIPKDKLVEPTFQEFYVHTDYKHLAQRSDIKLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL88</accession>
    <name>A0A182PL88_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PL88"/>
    <dbReference type="STRING" id="199890.A0A182PL88"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007705-RA">
        <property type="protein sequence ID" value="AEPI007705-PA"/>
        <property type="gene ID" value="AEPI007705"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007705"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF82">
        <property type="entry name" value="RNA EXONUCLEASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="414"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007705-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="783" mass="86648" checksum="F8C1DDCB0C5B48E5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLN5</accession>
    <name>A0A182PLN5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="12">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A182PLN5"/>
    <dbReference type="STRING" id="199890.A0A182PLN5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007855-RA">
        <property type="protein sequence ID" value="AEPI007855-PA"/>
        <property type="gene ID" value="AEPI007855"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007855"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023962689" description="CLIP domain-containing serine protease" evidence="12">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="14">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="109"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007855-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="290" mass="32462" checksum="541ADD0B458014A3" modified="2016-09-07" version="1">MERLVCLVVVSWSLIVVSRVGADDVLLNNGDACQTPSGTAGICEPVKNCSYVRKILQSPDFSHYDTTYLETLKCGEMTVPMRKKPIPLLCCPKFGNSPTCGAQNIADRIYFGEETERGEHPWAGLLFYNVGRNRTVPKCGGALVSERYVITAAHCTVDKPNWKLLYVRFNEFNSSSPDNCTTAEDDEIICREDYAVESIIPHPDYDMHNISRPNDICILRLATDVTFNDYVRPICLPFDLSIQQLPVVDEIFTVTGWGETEERRPSDIQKHVDLPGLDNEACNSVYAVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLQ0</accession>
    <name>A0A182PLQ0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLQ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007872-RA">
        <property type="protein sequence ID" value="AEPI007872-PA"/>
        <property type="gene ID" value="AEPI007872"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007872"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007872-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="261" mass="27791" checksum="5822C9B20CBEBE42" modified="2016-09-07" version="1">MALVNYTLPFGNIQAPAWATASPLQNQHASAVNNLLYGPAGHQGDDQDYYKNAPYAPPQRQAKQSPQQQQQQQHSIQYRQTPRNNYLPPPSYVPPGANYPQAPQPPQTQQPPGRTYGEGTYSDGTGSPPSAGTPQQSPQQPPSQQPAYYEYSSGSYATQPGRPFAEQHANPQTGTNYRSNTPQPAAPAAPAAAAAAAGSTAPRTAPNGGSYVQRPAVFASVGPGGTRTSIHPVLDYDEEEDDDYYDEAVEVTPIVGISGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLQ8</accession>
    <name>A0A182PLQ8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLQ8"/>
    <dbReference type="STRING" id="199890.A0A182PLQ8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007880-RA">
        <property type="protein sequence ID" value="AEPI007880-PA"/>
        <property type="gene ID" value="AEPI007880"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007880"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000031">
        <property type="entry name" value="Mannose-P-dolichol utilization defect 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007880-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="272" mass="29417" checksum="2316FDBDE12EF905" modified="2016-09-07" version="1">MVDYGKQFMLYLMDEKCYDNYFLEFNLLDGACWHGALVCDCFRALLSKGLGLGIIAGSVLVKVPQITKILANKSARGISLFSVCLDLFAITIHMAYSFVNGFPFSAWGDTAFLALQTAIIAMMVLFYGGSKVLAGVFTVGYTALVYVLMGGLTPLNYLLIAQGFNVPVLLLGKLSQAFTNYRNGSTGQLSAVTCFMLLAGSLARIFTSIQETGDQMMIITYGSSSFANLVIALQMLYYWNSSDKQQKKGKTAAATGGATAAKKPKAKSKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLY0</accession>
    <name>A0A182PLY0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper transport protein ATOX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Metal transport protein ATX1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Interacts with ATP7B. Interacts with ATP7A. Interacts (via dimer form) with SLC31A1 (via C-terminal domain); this interaction improves ATOX1 stability and controls intracellular Cu(I) levels.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLY0"/>
    <dbReference type="STRING" id="199890.A0A182PLY0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007952-RA">
        <property type="protein sequence ID" value="AEPI007952-PA"/>
        <property type="gene ID" value="AEPI007952"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007952"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007952-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="71" mass="7776" checksum="9FA35686BC94E3A3" modified="2016-09-07" version="1">MAVHQFKVEMTCTGCSGAVERVLGKLKEKVEKVEIDLDNKTVFVTSALSADELLETIKKTGKETSYVGVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMK6</accession>
    <name>A0A182PMK6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMK6"/>
    <dbReference type="STRING" id="199890.A0A182PMK6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008180-RA">
        <property type="protein sequence ID" value="AEPI008180-PA"/>
        <property type="gene ID" value="AEPI008180"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008180"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF1">
        <property type="entry name" value="LP10272P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008180-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="110" mass="12280" checksum="21CF96FDC1FC9206" modified="2016-09-07" version="1">MVIACVSFPFGWNSDEFRKVCGPESNRFEVGLCSLRWAYPLAIIACIDGFILATLSFILATRHVRLQPEPQYQSREINNAYVTDVASIAGSRKSLNLQPVLLVAPPHIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNR2</accession>
    <name>A0A182PNR2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enhancer of rudimentary homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the E(R) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNR2"/>
    <dbReference type="STRING" id="199890.A0A182PNR2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008591-RA">
        <property type="protein sequence ID" value="AEPI008591-PA"/>
        <property type="gene ID" value="AEPI008591"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008591"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2260.10:FF:000001">
        <property type="entry name" value="Enhancer of rudimentary homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2260.10">
        <property type="entry name" value="Enhancer of rudimentary"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035912">
        <property type="entry name" value="EHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000781">
        <property type="entry name" value="ERH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12373">
        <property type="entry name" value="ENHANCER OF RUDIMENTARY ERH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12373:SF0">
        <property type="entry name" value="ENHANCER OF RUDIMENTARY HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01133">
        <property type="entry name" value="ER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143875">
        <property type="entry name" value="ERH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01290">
        <property type="entry name" value="ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008591-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="20138" checksum="6C002799CA716F5E" modified="2016-09-07" version="1">MSHTILLVQPGQHPETRTYSDYESVNECMEGVCKIYEEQLKRRNPNTPTITYDISQLFDFVDQGSSVFARMSHTILLVQPGQHPETRTYSDYESVNECMEGVCKIYEEQLKRRNPNTPTITYDISQLFDFVDQLIDLSCLVYQKSTNTYAPYNKEWIKEKIYVLLRQAAGTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP27</accession>
    <name>A0A182PP27_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP27"/>
    <dbReference type="STRING" id="199890.A0A182PP27"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008706-RA">
        <property type="protein sequence ID" value="AEPI008706-PA"/>
        <property type="gene ID" value="AEPI008706"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008706"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035008">
        <property type="term" value="P:positive regulation of melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160032">
        <property type="term" value="P:Toll receptor ligand protein activation cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000015">
        <property type="entry name" value="Atrial natriuretic peptide-converting enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131614" description="Peptidase S1 domain-containing protein" evidence="13">
        <location>
            <begin position="24"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="156"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008706-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43011" checksum="17B2EAC980A97859" modified="2016-09-07" version="1">MLIKMGWRIGGTILLLLIASVAGQYGSCDLTYTYTSGQTAFIESPKFPQYYAPGSRCRYTINAPVGHTLYAQCYDMYLPSSTGCYYDKLAISRFGDANLSDAQIRCGTTTFNVESQYNRLVVALLGSTSTGGGRFRCQITALKLACDCGRRRTPTIVNGFPTQVNEFPMMSALAIRNNGQVFCGSTIVTDRYVLTAAHCLPGRSLSNTIVVVGEQDRRVSTESVYTMSMLVSEFRPHPSYDATAKTNDIALVRTTNTIVFNPGVGRVCLPFRFGASSFENARLSALGWGTIDFGAPQSDVLLQTTLAVVSSTTCGTQLSRTILASQVCTFAAGNDTCQNDSGGPLYYTDPNSQLVYNIGVVGFGVACASRFPSVNTRVTSYLDWIVTNTNYNFCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPE5</accession>
    <name>A0A182PPE5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPE5"/>
    <dbReference type="STRING" id="199890.A0A182PPE5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008824-RA">
        <property type="protein sequence ID" value="AEPI008824-PA"/>
        <property type="gene ID" value="AEPI008824"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008824"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF96">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131604" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="25"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008824-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="250" mass="27626" checksum="FC811107168C0956" modified="2016-09-07" version="1">MWSPLLLFLVIALQQLDQAVGQLRQIGGRDVPILEYPFMAAIAFQKQLAGNGAIIGPRWVITSASAVFAPTDSLFDVQVGADSFSGPGSWYEVRAIFKHPEFIGWDHNIALIHLKGPIKYSDTVQPIELADVFIEQFQVTMLSYGINENDSRHLREALYDASSNNECVQFLTDGLAKQMVMDQRGFCVRALPGTQQGQWYNDAGAPIVAYGKLHGVFAFAETEGGINQGAVGTRIYAFLDWIRATMAKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPF3</accession>
    <name>A0A182PPF3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPF3"/>
    <dbReference type="STRING" id="199890.A0A182PPF3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008832-RA">
        <property type="protein sequence ID" value="AEPI008832-PA"/>
        <property type="gene ID" value="AEPI008832"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008832"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131606" description="Peptidase S1 domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="39"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008832-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="285" mass="30611" checksum="753EAADBD46909B3" modified="2016-09-07" version="1">MKHTVYAVLALALLLTSVRSQRYTLAEEEEGYDPFVPFIAGGTNAVNGQFPSIVAVGLPAPPNNAFCGGVILNENHVLTSARCVLTPQNTLLFPNQLNILSGMLQLNFAAPRIGISAIYVHPQYNPFTFEHNIAVLRTSSNFFVPVVPVPNVDFAQFYEEIPFDGQPCQVAGWNNATATPVQQFINAPILNRDTCNGLAVHFGNIRESMVCAGATNAGPGVCASNLGTGLFCEGRIAGILSTGLGCGQANNPGVYTQIRFYLPWIREQFARQDIPLGGSSPIPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPI3</accession>
    <name>A0A182PPI3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPI3"/>
    <dbReference type="STRING" id="199890.A0A182PPI3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008862-RA">
        <property type="protein sequence ID" value="AEPI008862-PA"/>
        <property type="gene ID" value="AEPI008862"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008862"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008862-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="168" mass="17499" checksum="D162D5C1EBEB5594" modified="2016-09-07" version="1">RGQLQCYVCENCPDPFEGTSGQLQACPAGGSTTTQLPGGDTTILTPPPLPTGDGGNGQQTTTAPVTTTTEAPPTPSTPIITPPPLPGRRKRQTATGYRCFRIIHSNTVRRGCAAFLGTEVETCQSVNGGTTPDECTLCDWDECNSAAGLRVSLVALLLAVLLSAVLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPI9</accession>
    <name>A0A182PPI9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitinase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPI9"/>
    <dbReference type="STRING" id="199890.A0A182PPI9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008868-RA">
        <property type="protein sequence ID" value="AEPI008868-PA"/>
        <property type="gene ID" value="AEPI008868"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008868"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02876">
        <property type="entry name" value="GH18_SI-CLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000002">
        <property type="entry name" value="Chitinase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000028">
        <property type="entry name" value="Chitinase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46066:SF2">
        <property type="entry name" value="CHITINASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46066">
        <property type="entry name" value="CHITINASE DOMAIN-CONTAINING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131573" description="Chitinase domain-containing protein 1" evidence="8">
        <location>
            <begin position="24"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="83"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008868-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="399" mass="45220" checksum="DED2D776E079E715" modified="2016-09-07" version="1">MLPSKVLLCVSVATVLFSHVAFATLSPSDKNKNKKVKELKVKTGPQPTNVYDRGLVQGEPSAKDIIVENAAYFQDTSLKLFEGKVLGFVTPWNNHGYDVAKTWGPKFDYVSPVWLQILRKGPKKYEVAGVHDIDDGWVKDVKKAGSTINNRVVPRVLFDKFTDRDFSQLLTYPEERTIVAKLLLATARKHRFDGLVLEVWSQLAARVEDNYLIGLVEEICNTLTAASYDCILVIPPARKETYDLFSRKHFDALEPSVTGFSLMTYDYSSVQRPGANAPLYWVRNAVLHICPDGTDRMREKRAKILVGLNMYGSDFTPNGGQPIVSHEYLALLKHLKGHLTYDEHDVENFFEVKTSNGRHMVFYPTLFSIDERLKLARELGTGISIWELGQGLDYFYDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ69</accession>
    <name>A0A182PQ69_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PQ69"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009099-RA">
        <property type="protein sequence ID" value="AEPI009099-PA"/>
        <property type="gene ID" value="AEPI009099"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009099"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08521">
        <property type="entry name" value="C2A_SLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04020">
        <property type="entry name" value="C2B_SLP_1-2-3-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000310">
        <property type="entry name" value="AGAP005288-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000006">
        <property type="entry name" value="Synaptotagmin-like 5, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043567">
        <property type="entry name" value="SYTL1-5_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716:SF2">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="3612"/>
            <end position="3734"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="3797"/>
            <end position="3922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="603"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="708"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="873"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="997"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1054"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1128"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1198"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1331"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1541"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1615"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1960"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="745"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="839"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="894"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="481"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="627"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="900"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009510-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="975" mass="106288" checksum="4EA35638762596CA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRT2</accession>
    <name>A0A182PRT2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine protease K12H4.7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRT2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009667-RA">
        <property type="protein sequence ID" value="AEPI009667-PA"/>
        <property type="gene ID" value="AEPI009667"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009667"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF5">
        <property type="entry name" value="RE36938P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131672" description="Serine protease K12H4.7" evidence="6">
        <location>
            <begin position="20"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009667-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55206" checksum="E3A0A76511D710E3" modified="2016-09-07" version="1">MKASLALVCVAGCILGAFGLPQQQDGVQRVLRSQTAWERIHREPPIRGGSSSRKAGPVTTKYIMQRLDHFDPQNVNLWSMRYMENGEHYEEGGPLFIYVGGEWEISAGSISRGHVYDMASELKGYLFYTEHRYYGQSHPTVDLRTDKLKYLNIDQALADLAHFVVEMRKTIPGAEKSGVIMIGGSYSATMVSWFRQKYPHLINGAWASSAPLFAKVEFTEYKEIVTESIRLVGGQRCAERIERGVKQTEELLDRGEYASVAAEFKLCSDVDLSKPLDRMNFFSSLSDEFAGVVQYHSAGDIEGICRVIEDATITDDMVALAKVVTQGFTSPNCNSYGYATMVDFYKNTAWDQGAATSSMRQWLYQTCAEYGWYQISGSSNQIFGSSFPVDLFVKLCGDLYDGMFDKTRMLNNADRTNVIYGGWNPEVTNVFFTQGHLDPWRAMGIQQDLNADSPAVVIPGASHCADLSSISALDSDEMRAAKEKILELVKKWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PST6</accession>
    <name>A0A182PST6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PST6"/>
    <dbReference type="STRING" id="199890.A0A182PST6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010022-RA">
        <property type="protein sequence ID" value="AEPI010022-PA"/>
        <property type="gene ID" value="AEPI010022"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010022"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000113">
        <property type="entry name" value="homeobox protein Hox-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046327">
        <property type="entry name" value="HXA1/B1/D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010022-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="127" mass="14231" checksum="0C415443E5B1D005" modified="2016-09-07" version="1">MNNNSTGRTNFTNKQLTELEKEFHFNKYLTRARRIEIANALHLNETQVKIWFQNRRMKQKKRVKEGLVPPEVQSQSPKHSSMINSNDSSSASSSTAPIAAVASTSGTNNASTLNESNENSRESTTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTV7</accession>
    <name>A0A182PTV7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182PTV7"/>
    <dbReference type="STRING" id="199890.A0A182PTV7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010393-RA">
        <property type="protein sequence ID" value="AEPI010393-PA"/>
        <property type="gene ID" value="AEPI010393"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010393"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000597">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000001">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="470"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010393-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="876" mass="98174" checksum="3F08C7C538472488" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU58</accession>
    <name>A0A182PU58_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU58"/>
    <dbReference type="STRING" id="199890.A0A182PU58"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010494-RA">
        <property type="protein sequence ID" value="AEPI010494-PA"/>
        <property type="gene ID" value="AEPI010494"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010494"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000002">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010494-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="377" mass="43728" checksum="74AF8703C6FF1FE3" modified="2016-09-07" version="1">MGPPDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNELAREWTRNSSNSNRVQFTIYYQRRNNNTGDSSRSSKGNISQYGCRKQKITETQTLMSRDGIVTSSIINIYSSNKCFAVLRAQQQDNTPNEQYHHQQQENYITDYYTIIIDGNGSSGSSSYHQPENHLKEQWPQHQQQHPHHQHHQQQHQHFLLQNQQHPESDLILYYDYYNYYCFYNHCNTTNRSREEENGEDSSNSTDQLHNTNHCNDSNNSTPTPTYYYYISRYLMRKVRNGDVDGGVRAGSIVQKQLRPVAVPMLPVGDRYSCCCSYYCANAQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUA7</accession>
    <name>A0A182PUA7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Actin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUA7"/>
    <dbReference type="SMR" id="A0A182PUA7"/>
    <dbReference type="STRING" id="199890.A0A182PUA7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010543-RA">
        <property type="protein sequence ID" value="AEPI010543-PA"/>
        <property type="gene ID" value="AEPI010543"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010543"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010543-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41822" checksum="BDAF13C191BB1BBC" modified="2016-09-07" version="1">MCDEEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUR7</accession>
    <name>A0A182PUR7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUR7"/>
    <dbReference type="STRING" id="199890.A0A182PUR7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010704-RA">
        <property type="protein sequence ID" value="AEPI010704-PA"/>
        <property type="gene ID" value="AEPI010704"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010704"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF25">
        <property type="entry name" value="GH14967P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="104"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="203"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="300"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010704-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="423" mass="46463" checksum="5876F47030AB8ABC" modified="2016-09-07" version="1">MVIRDQTGIERTTVAGPYSEGDNIKLRCDVYGGRPTPTVTWYRDGVAMVADTKYMPLGKHLRSEIALGPLTRQDLHTKLVCRASNHARANPVEQSVQIDMNFAPLNIRLIGAHQPLSAGRRYDLLCQSAGSRPAASITWFLDGVRLDKSKETTSADGNQTTSTLSIVLNRTDAGKYLSCKAYNSYVQSDALEDGWQLDIQYVPDATVRLGSSLDPDAIREGTDVYFDCIVKAHPAVYKVEWKHNNKTLTRNISQGVIVSKHSLVLQGVSRTTAGNYTCVGFNAEGEGSSPTFELNVMYAPTCAPNQPRVYGVAKQENAEIRCVVDANPPDVEFKWTFNNSAESIDVQASHISRLGTSSIVSYTPMTELDYGTLLCSATNKIGKQRQPCVFHIIAAGELGKAQSFSEKQDDELQPPVIEIMRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV19</accession>
    <name>A0A182PV19_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Out at first C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PV19"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010806-RA">
        <property type="protein sequence ID" value="AEPI010806-PA"/>
        <property type="gene ID" value="AEPI010806"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010806"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026315">
        <property type="entry name" value="Oaf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053897">
        <property type="entry name" value="Oaf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13423">
        <property type="entry name" value="OUT AT FIRST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13423:SF2">
        <property type="entry name" value="OUT AT FIRST PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22873">
        <property type="entry name" value="OAF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Out at first C-terminal" evidence="1">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010806-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="105" mass="11857" checksum="F80A0B97FDD46864" modified="2016-09-07" version="1">MTRHYPFRSSISILESAVKLFPSANTVTAPSRCSDVSAIWAPCICTLEMCIGWYPCGLKYCKGKPENALQNNGGGGSYRCGIKTCRKCHQYSYYVREKQQCLWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV24</accession>
    <name>A0A182PV24_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PV24"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010811-RA">
        <property type="protein sequence ID" value="AEPI010811-PA"/>
        <property type="gene ID" value="AEPI010811"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010811"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010811-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="328" mass="33647" checksum="4ED3D06CF49C2CE5" modified="2016-09-07" version="1">MAELHQQDSSVGELQYGGTPPAGQLGGGGGGLGITQLGPCPPLVQQFGGTPPLGHPNGGLVCEKQNKECSLHRTMEGTFMGEQGIHWFTWVLELQADESVVHSSVLALHSDKAEDIRLLWGGTPPAGQLGGRVGGGGGGRVEVSAAVGHNNSDQYLRWYSSTGELLPLDSSEDELVAEVVVELEEVSAVVGHNNSGQYLRWYSSTGELLPLDSSEDELVAEVVVELEEVSAVVGHNNSGHSTVELRQQDSLVVGSVVEAVPVVALVAEGHNIQQYGGTPPAGQLGGGGGGGGLGTTQLGPWPPFVQQYGGTPPAGQLGGGGKGTFGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWB4</accession>
    <name>A0A182PWB4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWB4"/>
    <dbReference type="STRING" id="199890.A0A182PWB4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011251-RA">
        <property type="protein sequence ID" value="AEPI011251-PA"/>
        <property type="gene ID" value="AEPI011251"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011251"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000245">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000208">
        <property type="entry name" value="zinc finger protein Gfi-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011251-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="415" mass="45607" checksum="B48D30189448C66D" modified="2016-09-07" version="1">MAHLSPPPSPPVGQTPPAVSALNALNASASANLIQRASAFSSFLLPQQPITPVSPNLNVSTSRDYTLTPEKEEIVDEDMPLNLSMKPSTSTPNARHATLAHSINIWSPASMCEKETIDGDNQSNIDIENDDDSSGDLQIDESFDSQNYHHLHHHHHHHHHQQQQQQQQQQQRETARILTEYNSLLLNGAGRQSGGSRSSQDYFNYSKISKGYFTHLQQQQKNLEILRQNRTDLFVINGGVDNNNKEGVKNQNTAQQDRAAGAAGSVSGRMSRGSAGVGTSESDMMAISEQYAYGKSEVAGTGSSATRPDSTQPHSDSPYGSSNDSSSHGHSHSIVSTPTGEGKKSVKLYQCKQCGKTFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTYIHTGKIAHQFCFSLLLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX16</accession>
    <name>A0A182PX16_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX16"/>
    <dbReference type="STRING" id="199890.A0A182PX16"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011503-RA">
        <property type="protein sequence ID" value="AEPI011503-PA"/>
        <property type="gene ID" value="AEPI011503"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011503"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028213">
        <property type="entry name" value="PA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15364">
        <property type="entry name" value="PAXIP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011503-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="197" mass="21977" checksum="A194411BB734655F" modified="2016-09-07" version="1">MSADESWSVSCFDATDWMPSPEELETAYCALEKGTYTLELNWKCPGRRAPSPAKKDVPKVQKTVDKEAAAKNKEFDFMDDVALPQMRVRGQTSGPKGSAKKKTTNFAGFGVPMDWGERTIVDDQQSVDGLRADGRHEPPAHQQQHLLQQPLQQPLLQPVQQLHTYMPQSTTPSQQPPPHHSPLSLAIPISDALRHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX34</accession>
    <name>A0A182PX34_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PX34"/>
    <dbReference type="STRING" id="199890.A0A182PX34"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011521-RA">
        <property type="protein sequence ID" value="AEPI011521-PA"/>
        <property type="gene ID" value="AEPI011521"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011521"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011521-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="20041" checksum="9A7304C1C70AE639" modified="2016-09-07" version="1">MLNTHYEKLLKKVQNSLNNAQAVCLTSDSWTDINNSSFLADTAHFIHENNCTLRSECDEFTDRHSAENIGQWIRSDPRFKQKGFDNESLFKDCCVAILEQMNILNPQINEANEEAVRSRIENVTGPGESIWEEFDLDLENHPEIMLNSRSSNAIELDNYVAEPLVHRSDDPLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX71</accession>
    <name>A0A182PX71_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX71"/>
    <dbReference type="STRING" id="199890.A0A182PX71"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011558-RA">
        <property type="protein sequence ID" value="AEPI011558-PA"/>
        <property type="gene ID" value="AEPI011558"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011558"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011558-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="254" mass="29080" checksum="6AF7EE005BE674EC" modified="2016-09-07" version="1">MEDYLASVDQPYSASFPLFNQSQVSARKCTSRELPVFSGDPKEWMAFISNYEHSTAICGYTNDENMLRLQACLKGKAREAVASCLLYPDSIPEAIEILKECYGRPELVVNTLMADIRRLPSPKDDRFDALVDYGVAVRNFCASVTGSGLHSYFDGGPLLEELVDKLPPYVRLNWYYYQNRCSHTTLEVFNEWMKELVGAASRGVKHTGGRRKVKHENSIRQYDRKSYDRSSSKRSIRRSDRSNSATTTDHRRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX78</accession>
    <name>A0A182PX78_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX78"/>
    <dbReference type="STRING" id="199890.A0A182PX78"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011565-RA">
        <property type="protein sequence ID" value="AEPI011565-PA"/>
        <property type="gene ID" value="AEPI011565"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011565"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011565-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="54167" checksum="E95085561DBAE33F" modified="2016-09-07" version="1">LEPCSIEEYIEEAEYTRDWINIDEFDNKEGYADLNDDEEEVEVYQDTPQVSSDDDLPADELIRNWALKTYQSHQALNGLLEILRKLGHQLPKDARTLLRTKQCGKEIVSISGGEFWFPGIRATLKNNFRDIQPRVSSFSLNISVDGLPLHKSTRKQFWSILISIQERPETPVLMIGNFLGESKPSSVEQYLRPLVDELNDLIQNGIQISNKFIEVRVRAFIADSPARAFIKGVAYFNQKIGCQRCTVEGRYHNIARVMCFPGIDAPPRTDEDFRNGKYGDHHRERTPLRDLLWFNLITNVVVADCLHLIDYGVTRTMLKGWMLGKLGTHGKWSSNTLSKINSLLKQVELPLEFHRKFRNIEDIGLWKASEFKMFLRYASFVVLKEALTETEYQHFMLYFCAITLLSSEVYREFWYEANELLRQFVINYGLIYASCNMLKNHFEMVIRYWFKLQIGTNTKISIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PXX7</accession>
    <name>A0A182PXX7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PXX7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014196-RA">
        <property type="protein sequence ID" value="AEPI014196-PA"/>
        <property type="gene ID" value="AEPI014196"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014196"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014196-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="158" mass="15840" checksum="611DFB59149CC012" modified="2016-09-07" version="1">MSVSLKKVSSALSLPAGCGISGISKTSPTTGTSLLSSGISSSMITLAGSMHQPTCQRQATSLQALLEGRILATGRTVASLGLDSASLIHGKSTSKGEESHGERRRHHQGSISDHHQPSTAQLAALALGTVEPGSSSNQQPSTHHHGGGPAGSGEQGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYT2</accession>
    <name>A0A182PYT2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PYT2"/>
    <dbReference type="STRING" id="199890.A0A182PYT2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014474-RA">
        <property type="protein sequence ID" value="AEPI014474-PA"/>
        <property type="gene ID" value="AEPI014474"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014474"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031874">
        <property type="entry name" value="Cuticle_Acp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12336">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12336:SF0">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15955">
        <property type="entry name" value="Cuticle_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131912" evidence="1">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014474-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="156" mass="15951" checksum="98BE804543B5C01C" modified="2016-09-07" version="1">MKCIAAVVMVALVASAQAVYYNAVPSVYSVPATTVVQQNVVPKYVTAYSAPAVTYASHASVAPVAAYAAPVAATYAAPISYAAHSSVVQAPVAYAAPAAYAYGHSNYVQAVPTVYAQVQKEATYVAATRGAVHKAPLVGHAINQKSLNIEPAPGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYU9</accession>
    <name>A0A182PYU9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYU9"/>
    <dbReference type="STRING" id="199890.A0A182PYU9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015017-RA">
        <property type="protein sequence ID" value="AEPI015017-PA"/>
        <property type="gene ID" value="AEPI015017"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015017"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015017-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="506" mass="57300" checksum="FC90F64918334852" modified="2016-09-07" version="1">MAYLSVVVFLVVPALTMLYFYLKQHYRYWTNRNLPQLDASFPLGNMKGVGSEIHFTDVLNEAYAKGKAQKSPLVGLYFMLKPILIVTDLNMVKRILVKDFNSFHDRGLYVNERDDPLSGHLFALDGERWRYLRNKLSPTFTSGKIKLMFATIREIGDEFLASVNRYVERDEPVDVKLLAQCFTCDVVGSCAFGLQCNSLKNEGSKLLEIGDKVFKPPAWRNMLAFALISFKKLAKQLHLPALPGEVTSFFMPLVSETVADRERNAIERPDFLNLLIQLKNEGTVEGEVTEGLQKLTLDEVAAQAFVFFFAGFETSSTTLSFALFELANNPTIQERVRAEVLEKLKLHDGNITYDALKEMTYLDQVINETLRMYPPVSQLIRVSTQPYPVEGTNVTLEPDTMLMIPTYAIHHDAGIFPDPERFDPDRFALAATHARHTHAFLPFGDGPRNCIGMRFGLLEVKFGIVQMVSKLRFTVSERMQTPIRISKMATILEVEGGIWLNASKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ29</accession>
    <name>A0A182PZ29_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZ29"/>
    <dbReference type="STRING" id="199890.A0A182PZ29"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015097-RA">
        <property type="protein sequence ID" value="AEPI015097-PA"/>
        <property type="gene ID" value="AEPI015097"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015097"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF134">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015097-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="649" mass="75298" checksum="E0067ABC678AE94E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PPU9</accession>
    <name>A0A240PPU9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PPU9"/>
    <dbReference type="STRING" id="199890.A0A240PPU9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015364-RA">
        <property type="protein sequence ID" value="AEPI015364-PA"/>
        <property type="gene ID" value="AEPI015364"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015364"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013371819" description="Peptidase S1 domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="51"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015364-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="288" mass="31324" checksum="5952DAC491F8C8C7" modified="2017-10-25" version="1">MVKYCALVLLAGCSLYAFAASTGEIRSAQDVDWSQVHRFYDPQAEVPDRRINNGQIASPTDVPWAVGLLVSLASGTSFCGGALISPTHVLTAASCVNGQSSITAMLGASTIATTSDFVPVSHVRVHPDYSSFLDRDDIAILTLARQPRWNDQIQIINLPRRMYIGHSFNNYITTISGWGETGTNTGEPLPMPNLRFIRSPVITNLSCELSFLLNNIRSTHICTSTDGGAPCVGDQGAPVTVTENGETFLIGIHVFTASRCERGRPAVHVRLTEYMNWLELNTDALIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWM1</accession>
    <name>A0A3F2YWM1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWM1"/>
    <dbReference type="STRING" id="199890.A0A3F2YWM1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015459-RA">
        <property type="protein sequence ID" value="AEPI015459-PA"/>
        <property type="gene ID" value="AEPI015459"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015459"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015459-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="248" mass="26572" checksum="1CD629B55B794049" modified="2019-01-16" version="1">MYYRNTLPMMAYPQLQQTAMYRQAMYQNQRLRNYHRRSAASGVAAFAAGDTIATGTQILKADCRPADPAADAYPSVQSFADAYPAEAVPENEIPLSDDGGQLEQDANAGSELDFALENEEPLEDIPAAAPVVPTTDKRKKKVTVQLDSASAEEDQEDEEQVSFGTRRGSAGRPSGGSSGPMFPVTFGSTNGGAIAIANSYSTGKGGSATSHATAYGSPASVPEERRRAVILQQQQQRSIRPAKLRTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWM7</accession>
    <name>A0A3F2YWM7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWM7"/>
    <dbReference type="STRING" id="199890.A0A3F2YWM7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015466-RA">
        <property type="protein sequence ID" value="AEPI015466-PA"/>
        <property type="gene ID" value="AEPI015466"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015466"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000092">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="31"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015466-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="595" mass="66550" checksum="F9EB67B38325D4A1" modified="2019-01-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0C7</accession>
    <name>A0A182P0C7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0C7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000359-RA">
        <property type="protein sequence ID" value="AEPI000359-PA"/>
        <property type="gene ID" value="AEPI000359"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000359"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000359-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="187" mass="20799" checksum="CA2B076EF8F068BA" modified="2016-09-07" version="1">MKLPKWIRRTPKSNVGVKSIVKSSGHSSDGGGSQRHRRKSCSASLKGKRKRNSYVSSAITTKNFYPAEHFFKTAPSPGHLDGGSRAVEEMEKMARYRTLPASFRSVAYQQGVHPSGLAGYYGQQQQQQQQQQHHAHPLGLPNYNGSIRNHRAVAPNGMQLAQQYHLPNGMHVSLPQYQPNAQTKAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P129</accession>
    <name>A0A182P129_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P129"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000611-RA">
        <property type="protein sequence ID" value="AEPI000611-PA"/>
        <property type="gene ID" value="AEPI000611"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000611"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="70"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="771"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1096"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1760"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1955"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2098"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1768"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1955"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2101"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2117"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2153"/>
            <end position="2166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000611-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2267" mass="241519" checksum="F6703002EF1DA065" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P209</accession>
    <name>A0A182P209_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P209"/>
    <dbReference type="STRING" id="199890.A0A182P209"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000943-RA">
        <property type="protein sequence ID" value="AEPI000943-PA"/>
        <property type="gene ID" value="AEPI000943"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000943"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001136">
        <property type="term" value="P:negative regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="83"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="269"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000943-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="55115" checksum="2C43D1BD1C0AD089" modified="2016-09-07" version="1">MIDSTEDPHPSLSDWHDYEPNLEFDDTELSHPSPEPGTTTVFDDINYSAEFEIPTEDEIIKTTLEADNYEEQLTMVGHDENAIRKDFKRRKFIEFIGTDKQGQPIIAIYACRLPERKDLNSNIFIDFIIKSMEEFVQNDYIIAYFHQGMKDNSKPALQFLWNSYKELDRSFKKNLKKLYVVHPTTFIRMVWFFFKPIISEKFKSKLIYTSSLDELKQSLGLNTLKVPDPVREFDEKINNAARYTLRGSKSSLKSSRSLENLPKSAQFGVSLRFIIENSACLNCIPPIVRKCVDHLSLPDVVETEGIFRRSGNYARIKELRAKINAGEEVQLCNEDTHVVASLLKTFLRELEEPLLTYELYEDITQFSEWKTEEARSRNVKQLLRERLPEENYELFKYIVEFLGKIMERKDFNKMTSSNLSIVFGPNLVWPKQEQMSLDEIGPINAFIDYVLQHQDDIYFVDINKKDRGTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P214</accession>
    <name>A0A182P214_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">OBP47-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P214"/>
    <dbReference type="STRING" id="199890.A0A182P214"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000948-RA">
        <property type="protein sequence ID" value="AEPI000948-PA"/>
        <property type="gene ID" value="AEPI000948"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000948"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054577">
        <property type="entry name" value="OBP47-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052295">
        <property type="entry name" value="Odorant-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066:SF3">
        <property type="entry name" value="IP02236P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066">
        <property type="entry name" value="ODORANT-BINDING PROTEIN 59A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22651">
        <property type="entry name" value="OBP47_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130730" description="OBP47-like domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="OBP47-like" evidence="9">
        <location>
            <begin position="43"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000948-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="201" mass="22127" checksum="C986FE392E1C9BDE" modified="2016-09-07" version="1">MNPMYSKVFLVLCSTLLVTVSGAPNTCGKLDLKTDPFTCCTIPKLLDVAIVGSCFEKFPIDKDAMDKGAGSMPRTECMSECILNSTGIYNRRAELDEKKLTSVFTDSLPTNSPWLNVVRKAIKECSTKANKKDKEFVKAVADQKKASPKGTQVCNPEASFLVDCIHTTVFSDCPTNLRSTTSECDAIWNFLKNCPFSALRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P231</accession>
    <name>A0A182P231_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P231"/>
    <dbReference type="STRING" id="199890.A0A182P231"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000965-RA">
        <property type="protein sequence ID" value="AEPI000965-PA"/>
        <property type="gene ID" value="AEPI000965"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000965"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF136">
        <property type="entry name" value="GH06673P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130733" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="60"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000965-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="310" mass="33206" checksum="735D603A149F8BF5" modified="2016-09-07" version="1">MKCAVSLALVGLLALLHGVSSFEIDWTEVRPIEEFDHIKAHLPIRLRSPAAESNSPNRRIVNGQEARPGQFPYQVALLGQFNTGVGLCGASIITQFYVLTAAHCVYTGTDASNPVANGTAILGAQNRIIEEPSQQRITFSASGVIGHPGYDLFTVRDDIAVVRLDEPIVYTDRIQPIRLPARSDTRTFAGLMGTVSGFGVYSVANPGLSDVLNYVLNPIITNADCRSKKGTVQWLIEDQNICQSGDGGRGACNSDSGGPLTVQDNGESLQVGVVSFGSAGGCDDGIPTVFARLTYYLEWIEANSDFTPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2G4</accession>
    <name>A0A182P2G4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA polymerase eta</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182P2G4"/>
    <dbReference type="STRING" id="199890.A0A182P2G4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001098-RA">
        <property type="protein sequence ID" value="AEPI001098-PA"/>
        <property type="gene ID" value="AEPI001098"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001098"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pterygota</taxon>
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            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="10">SH2 domain-containing protein</fullName>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Haas B."/>
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                <person name="Chapman S.B."/>
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                <person name="Griggs A."/>
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                <person name="Larimer J."/>
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                <person name="Wortman J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
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        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
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        <text evidence="1">Belongs to the SH2B adapter family.</text>
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            <end position="190"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
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    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001183-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="69074" checksum="0A5556A5CF28909D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2W5</accession>
    <name>A0A182P2W5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
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    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
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        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
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        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF98">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="282"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="9"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="637"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="764"/>
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        </location>
    </feature>
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        <location>
            <begin position="1021"/>
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        </location>
    </feature>
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        <location>
            <begin position="643"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
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            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001251-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1049" mass="116727" checksum="935E65744C51AD78" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P371</accession>
    <name>A0A182P371_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GDNF/GAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDNFR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P371"/>
    <dbReference type="STRING" id="199890.A0A182P371"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001355-RA">
        <property type="protein sequence ID" value="AEPI001355-PA"/>
        <property type="gene ID" value="AEPI001355"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001355"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057681">
        <property type="entry name" value="DUF7921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059035">
        <property type="entry name" value="Fn1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016017">
        <property type="entry name" value="GDNF/GAS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037193">
        <property type="entry name" value="GDNF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003438">
        <property type="entry name" value="GDNF_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269">
        <property type="entry name" value="GDNF RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269:SF12">
        <property type="entry name" value="GLIAL CELL LINE-DERIVED NEUROTROPHIC FAMILY RECEPTOR-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25537">
        <property type="entry name" value="DUF7921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25868">
        <property type="entry name" value="Fn1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02351">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00907">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110035">
        <property type="entry name" value="GDNF receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="10">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="10">
        <location>
            <begin position="116"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001355-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="649" mass="72615" checksum="0D45AF245699CA9D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3S1</accession>
    <name>A0A182P3S1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3S1"/>
    <dbReference type="STRING" id="199890.A0A182P3S1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001556-RA">
        <property type="protein sequence ID" value="AEPI001556-PA"/>
        <property type="gene ID" value="AEPI001556"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001556"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001556-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="249" mass="27654" checksum="7367B998EACB7DFE" modified="2016-09-07" version="1">MEPVDCDPAVSSSSSGVTVLQYLLQNESTGAIVGGESQTSSSTIGAGPSVRIYPCTHPGCKKTYLNEEHQKAHEKYHSGDVPSHRKQAEVREGHMSADAEEKQSGLRFLLQNGQFELLPKARDSTEEIGEEEVFGESSDEEGNGKQPESIVVECTETNEDDLIEYEGDDARKDVEFENSFIQYEGSDCEATEAVEMISQEAVSDTDSDEDEDSSLDEPKQHTYSAKERKYVCEWPRRICYQPELFTSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4N4</accession>
    <name>A0A182P4N4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4N4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001870-RA">
        <property type="protein sequence ID" value="AEPI001870-PA"/>
        <property type="gene ID" value="AEPI001870"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001870"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001870-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="77" mass="8795" checksum="530B07D7F473C788" modified="2016-09-07" version="1">MTERKFTRGLNKPGMAAQLRENISQVVLVRIVISRLHDSKQQTTTRKCFISTISIFVVAHRESLSLIADRVAQGQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5U2</accession>
    <name>A0A182P5U2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5U2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002283-RA">
        <property type="protein sequence ID" value="AEPI002283-PA"/>
        <property type="gene ID" value="AEPI002283"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002283"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002283-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="265" mass="29591" checksum="B1601BE847B51892" modified="2016-09-07" version="1">MPETLEQLKIGLENITHVHVNTNKPNTSTGLSSQASTTAFSAMVSPHAISQPLPTETGHSQQQPQVIFYQSQEYIISDSTTVGLDETIDPSTSTGALPKAQEYILEGTTYAAVVAGDYLTQSAQQHHSTTNDTSSMVESLELSQEYPSRRTSAEFGNTSFGEGSLEINFNKEMPGEPNTAIDSSILYIREKQLTNQGSVDRIDRFKPYRNLHHLNHSHNQIIAFIHAHSLRQLMKNLAKASHRNITIKRQQMFPKFLHRTSLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6S0</accession>
    <name>A0A182P6S0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridine 5'-monophosphate synthase</fullName>
            <ecNumber evidence="6">2.4.2.10</ecNumber>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="6"/>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="STRING" id="199890.A0A182P6S0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002618-RA">
        <property type="protein sequence ID" value="AEPI002618-PA"/>
        <property type="gene ID" value="AEPI002618"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002618"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09769">
        <property type="entry name" value="Luminal_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13982">
        <property type="entry name" value="STKc_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000245">
        <property type="entry name" value="Bifunctional UMP-synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000077">
        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000025">
        <property type="entry name" value="Uridine monophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="21" id="KW-0456">Lyase</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="520"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="27">
        <location>
            <begin position="794"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="25">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="23">
        <location>
            <position position="1198"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="23">
        <location>
            <position position="1200"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="23">
        <location>
            <position position="1203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00015047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002618-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1381" mass="152661" checksum="86D062271169FB1F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6S6</accession>
    <name>A0A182P6S6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6S6"/>
    <dbReference type="STRING" id="199890.A0A182P6S6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002625-RA">
        <property type="protein sequence ID" value="AEPI002625-PA"/>
        <property type="gene ID" value="AEPI002625"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002625"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1100">
        <property type="entry name" value="FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002625-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="158" mass="15343" checksum="AFCE72FE6A21820F" modified="2016-09-07" version="1">MDLQAAGHNVSEANIIQLKVSGVTIAIGKVRRKGEPGEPGPPGPPGPPGASGAIGLDGRQGPPGDPGPKGDPGPPGEKGPVGNPGTPGLPGAKGDRGDKGDRGLTTHFKGDQFPAGIIEGPPGPPGPPGPPGEKGDPGPEGPPGPQGEKGPRGKRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P759</accession>
    <name>A0A182P759_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P759"/>
    <dbReference type="STRING" id="199890.A0A182P759"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002761-RA">
        <property type="protein sequence ID" value="AEPI002761-PA"/>
        <property type="gene ID" value="AEPI002761"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002761"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002761-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="209" mass="20633" checksum="12CA320CA7FE161C" modified="2016-09-07" version="1">MASQRSASPPDGGGGGGCGGGGGGGGGGSSVHGGHGMSRLSLPLPLAACHRCDVCGKLLSTKLTLKRHKEQQHLQPLNNAVCNLCHKVFRTLNSLNNHKSIYHRRQKILHHHHHAHHPHHPLHAQHPFAVGGGGGGAGGGAGGGGGGGGGGAVSPLHHGAAHAAVAAAAVAAAAAAAGGHHELLNNNAAGGATDCDIKHNNVAAKLEYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P898</accession>
    <name>A0A182P898_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P898"/>
    <dbReference type="STRING" id="199890.A0A182P898"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003151-RA">
        <property type="protein sequence ID" value="AEPI003151-PA"/>
        <property type="gene ID" value="AEPI003151"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003151"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051762">
        <property type="entry name" value="UBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318">
        <property type="entry name" value="UPSTREAM BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318:SF3">
        <property type="entry name" value="UPSTREAM BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="117"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="117"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003151-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="669" mass="76103" checksum="9427E7B503927F1E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8C0</accession>
    <name>A0A182P8C0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein bicaudal D</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8C0"/>
    <dbReference type="STRING" id="199890.A0A182P8C0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003173-RA">
        <property type="protein sequence ID" value="AEPI003173-PA"/>
        <property type="gene ID" value="AEPI003173"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003173"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034452">
        <property type="term" value="F:dynactin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072393">
        <property type="term" value="P:microtubule anchoring at microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018477">
        <property type="entry name" value="BICD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233">
        <property type="entry name" value="BICAUDAL D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233:SF6">
        <property type="entry name" value="PROTEIN BICAUDAL D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09730">
        <property type="entry name" value="BicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="751"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="319"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="697"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003173-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="90288" checksum="B3ABB9AB18B0164F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8D8</accession>
    <name>A0A182P8D8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8D8"/>
    <dbReference type="STRING" id="199890.A0A182P8D8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003191-RA">
        <property type="protein sequence ID" value="AEPI003191-PA"/>
        <property type="gene ID" value="AEPI003191"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003191"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000010">
        <property type="entry name" value="probable elongation factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="7">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="135"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003191-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24171" checksum="A18B0B6E95B71AEB" modified="2016-09-07" version="1">MAFGDVKTANGLKELDKFLADHSYVEGFTPSKADLSVFDALGKAPASTYVHALRWYNHIASFNAKERSEWGGQALPQVAGGKPTAAAPAGGDDDDDVDLFGSEDEEESAEAAKLKEERLAAYNAKKSKKPALIAKSSIILDVKPWDDETDMKEMEKNVRSIEMDGLLWGAAKLVPVGYGIHKLQICCVIEDDKVSVDLLTEKIQEFEDYVQSVDIAAFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P916</accession>
    <name>A0A182P916_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein CDV3 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDV3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P916"/>
    <dbReference type="STRING" id="199890.A0A182P916"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003420-RA">
        <property type="protein sequence ID" value="AEPI003420-PA"/>
        <property type="gene ID" value="AEPI003420"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003420"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026806">
        <property type="entry name" value="CDV3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16284">
        <property type="entry name" value="PROTEIN CDV3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16284:SF13">
        <property type="entry name" value="PROTEIN CDV3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15359">
        <property type="entry name" value="CDV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003420-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25331" checksum="00C2CB2A90587C6E" modified="2016-09-07" version="1">MADLDDFFAKKDKKKGKAKKFVTAEEIAKQLDDTSKKVVESKMKLRQVDSGDGKHDSKEAEDEWKVFEETKKDYSGLKLAQLTIDEEANQHDADNGDPNDQSYDGEGRDGEDRDPSKPWNKLDAANAAKKEKAAPAPEPATTSNIYISPAMKSLMAKQKQKKGIAPDLQSEEYFPTLGQEKPAEQPKPPKADPSFEEVKHGVRAKPVEQSSSSQISTGNRYTSLNNDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P950</accession>
    <name>A0A182P950_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P950"/>
    <dbReference type="STRING" id="199890.A0A182P950"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003454-RA">
        <property type="protein sequence ID" value="AEPI003454-PA"/>
        <property type="gene ID" value="AEPI003454"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003454"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF32">
        <property type="entry name" value="RAP GTPASE ACTIVATING PROTEIN 1, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21022">
        <property type="entry name" value="Rap-GAP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="269"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="750"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="621"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003454-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="861" mass="92340" checksum="7520791C59D4FF29" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P955</accession>
    <name>A0A182P955_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A182P955"/>
    <dbReference type="STRING" id="199890.A0A182P955"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003459-RA">
        <property type="protein sequence ID" value="AEPI003459-PA"/>
        <property type="gene ID" value="AEPI003459"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003459"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
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    </dbReference>
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    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="27"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="179"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="452"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="21">
        <location>
            <begin position="564"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="670"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1035"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00025539"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003459-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1144" mass="129093" checksum="827BFAB135400EB2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P992</accession>
    <name>A0A182P992_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ELM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="AEPI003496"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:transcription regulator complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF28">
        <property type="entry name" value="REST COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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            <end position="154"/>
        </location>
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        <location>
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            <end position="187"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003496-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20925" checksum="58D6A437C3F78096" modified="2016-09-07" version="1">MVLAERTAEGGVRNGKRSRGPSPNGHAGAGIVSTSGTAGGATDSSSDDENSRKNGNTSKTTKTKSEYEEKIRVGRDYQAVCPELIAPAERKPEQLNDRALLVWSPTKEIPDNKLEEYITVAKEKYGYNGEQALGMLFWHKHDLERAVLDLANFTPFPDEWSAEDRVLFEQAFQFHGKSFHRIRQMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9L5</accession>
    <name>A0A182P9L5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxiredoxin-5</fullName>
            <ecNumber evidence="9">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A182P9L5"/>
    <dbReference type="STRING" id="199890.A0A182P9L5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003620-RA">
        <property type="protein sequence ID" value="AEPI003620-PA"/>
        <property type="gene ID" value="AEPI003620"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003620"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="41"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003620-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="194" mass="20482" checksum="36D5469B32DF390D" modified="2016-09-07" version="1">MHSFVRSSYAVVKNSFVLNQCGRPVSLNAAATFHTSKMVQIKEGDKIPSIDLFEDSPANKVNVADLCAGKKVILFAVPGAFTPGCSKTHLPGYVEKAGDLKSSGATEIVCVSVNDPFVMSAWGKQHNATGKVRMLADPAAAFTKALDLGADLPPLGGLRSKRYSMVLEDGVVKSLNVEPDGTGLSCSLADKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA61</accession>
    <name>A0A182PA61_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PA61"/>
    <dbReference type="STRING" id="199890.A0A182PA61"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003815-RA">
        <property type="protein sequence ID" value="AEPI003815-PA"/>
        <property type="gene ID" value="AEPI003815"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003815"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="16"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003815-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="333" mass="37617" checksum="2143956F61883DDA" modified="2016-09-07" version="1">MYQPLEKENLFTKYIRIAVVVAAYWVISILTVFVNKALLSGLKLDAPLFVTWFQVLTSSTICFTMSMLGKRYPRAVNFPEGNPFDRETFRKVLPLSILFTAMIATNNLCLKFVGVAFYYVGRSLTTVFNVLLTYALLGQKTSSKAILCCVLIVVGFWIGVDQESLTESFSLIGTIFGVLGSLSLSLYSIYTKRTLQHVNQEVWLLSYYNNVYSSVLFIPLMIINGEVQEVLNYEHLFEGWFWGVMTIGGVCGFAIGFVTTLQIKVTSPLTHNISGTAKACAQTVIATSWYQETKSFLWWTSNVVVLLGSAFYTRVKQLEMDQLHREQMNSQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAB0</accession>
    <name>A0A182PAB0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AP-3 complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAB0"/>
    <dbReference type="STRING" id="199890.A0A182PAB0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003864-RA">
        <property type="protein sequence ID" value="AEPI003864-PA"/>
        <property type="gene ID" value="AEPI003864"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003864"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056314">
        <property type="entry name" value="AP3B1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029390">
        <property type="entry name" value="AP3B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14796">
        <property type="entry name" value="AP3B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24080">
        <property type="entry name" value="AP3B1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01355">
        <property type="entry name" value="AP3B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP-3 complex subunit beta C-terminal" evidence="13">
        <location>
            <begin position="881"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="650"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="714"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="789"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="819"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003864-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1169" mass="127316" checksum="7B82D783114CC5D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAK4</accession>
    <name>A0A182PAK4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAK4"/>
    <dbReference type="STRING" id="199890.A0A182PAK4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003959-RA">
        <property type="protein sequence ID" value="AEPI003959-PA"/>
        <property type="gene ID" value="AEPI003959"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003959"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF11">
        <property type="entry name" value="FI13065P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003959-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="44271" checksum="DA15042920B2C1D3" modified="2016-09-07" version="1">MVQKPDRYWVVFCVHDDCEAFLEGYSDPRQAPSHAPEWALSLQTVQHVSHALVSVEQEFEFVITLGTEVARFNANTWECMQEWVECLRSKLREMKLLSPKENLYSRLPEVRPPLAPTRDPTSPLPATPPVPAAIVPGIERVQPPSLHSQGHHSSLAGISGQTASLSTGVSSGSAGTSSTIVSNTGTTSSISSSSSSASSSSSSSSSSSGSSYSSTLTSISNCPNGERGSAAGPPAMSNTSTQNLMNLLSNPLQAVSSINAQANKHPPASTTENGSLGSTSSLVSEEDRSALEESLTCIISASPPRDVPSSSSMPKPQKIINRDNGTAGHHNHHPVVTVASGSSSTTTSSLATTFVTNVLADPSGTAGPSVKRAINDKKLLLDVRQSASERFTAGCDADDVVVPDVSNGHTNDGKNACPSLVGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAQ5</accession>
    <name>A0A182PAQ5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAQ5"/>
    <dbReference type="STRING" id="199890.A0A182PAQ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004010-RA">
        <property type="protein sequence ID" value="AEPI004010-PA"/>
        <property type="gene ID" value="AEPI004010"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004010"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="3">
        <location>
            <begin position="222"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004010-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="341" mass="36174" checksum="679D8BA062904609" modified="2016-09-07" version="1">MAQQVQQVFKAAMAKTAGQRAMSTGVIGTLEGSVAKKGAAQSSGLHMSVQRSYPQAAALPLPPNIDASETRRFSPLRSRDINATALLTHQSFAPPNAVTGQIDVTVDMSAGSAIDPHVESYDCTGAVSLNSSMQSNVPSPFGGMHKFTHLNMPGGAWAQESKFLSHELNSSHYTNLRQEVRSDWSSYEDRPIKPEGEPNSKGSGSSSGVTNEEQIPVSRKDRLKKAIKEYGSTVLVFHVSISLASLGTCYLLVSSGIDMVSLLERMGWGDSALASKAGAGAGTFVIAYAIHKVFAPVRISITLGATPLIVRYLRRKGILKPPAPSSNSSSSPVSSKPTEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAS2</accession>
    <name>A0A182PAS2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">pH-sensitive chloride channel 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Ligand-gated chloride channel protein hodor</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:29824"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 16">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAS2"/>
    <dbReference type="STRING" id="199890.A0A182PAS2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004027-RA">
        <property type="protein sequence ID" value="AEPI004027-PA"/>
        <property type="gene ID" value="AEPI004027"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004027"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000042">
        <property type="entry name" value="Blast:Glycine receptor subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="17">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="254"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004027-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="479" mass="54521" checksum="D9EB10BF5AAFCFF4" modified="2016-09-07" version="1">MELCKRDSECPTLEGADHLSQTQLLTRLTHVCRYDRLERPKRESINGTNGPVKVYARAYIYFMQNLEAHDLQFKIHALLQFRYVDPRLVFREVAPNRTKPIMGEQSLRDLLWVPHVFLANERSSDILGTAEKDILTSISPDGTVIVSTRISATLYCWMNLQKFPFDEQHCSTVLESWMYNLDDLVLLWEHKSPVTLAPELHLTEYVLLEMFTNETVINADLSDLRHGAFAGNYSSLSFTVHLAREMGFYMMDYFIPSIMLVAISWVTFWLQADQSAPRITLGTSTMLTFITLASAQGKTLPKVSYIKASEIWFLGCTGFIFGSLVEFAFVNTIWRRKRNVEVKKVNSKHVLKQAITPRPARKDMSGLHKSHSCTSLADSATTVSANSFNNYLTVHSIPQKSPSSATLPIIATTDVDRAMADASNVTIQIEGQTSNVNGNGWTTMTPQEVAIWIDKRSRFVFPIAFVIFNIFYWTFVYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBJ0</accession>
    <name>A0A182PBJ0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBJ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004295-RA">
        <property type="protein sequence ID" value="AEPI004295-PA"/>
        <property type="gene ID" value="AEPI004295"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004295"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="1">
        <location>
            <begin position="574"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004295-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="647" mass="73930" checksum="D03B3B4E4138F51D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBK5</accession>
    <name>A0A182PBK5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBK5"/>
    <dbReference type="STRING" id="199890.A0A182PBK5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004310-RA">
        <property type="protein sequence ID" value="AEPI004310-PA"/>
        <property type="gene ID" value="AEPI004310"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004310"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF116">
        <property type="entry name" value="DOUBLESEX-MAB RELATED 99B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="7">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004310-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="182" mass="19902" checksum="8BDCFCBBBD85A5E4" modified="2016-09-07" version="1">MMSLPSGVDMSNLMQQHPVLGALPPAFFLRAASERYQRTPKCARCRNHGVVSALKGHKRYCRWRDCVCAKCTLIAERQRVMAAQVALRRQQAQEENEVRDLGLLYGTTGVHGVGQTPPSDPGAVQSVGQFHGGIPSPPNDAESATHHSYTSADADTDVQRLRSEHMHSAYSPNRSEPDSPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCC9</accession>
    <name>A0A182PCC9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCC9"/>
    <dbReference type="STRING" id="199890.A0A182PCC9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004584-RA">
        <property type="protein sequence ID" value="AEPI004584-PA"/>
        <property type="gene ID" value="AEPI004584"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004584"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000035">
        <property type="entry name" value="HBS1-like translational GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037189">
        <property type="entry name" value="HBS1-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109732">
        <property type="entry name" value="HBS1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="17">
        <location>
            <begin position="777"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="721"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="724"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="757"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004584-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1203" mass="137244" checksum="ED1885F0E6A80F3A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCE6</accession>
    <name>A0A182PCE6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCE6"/>
    <dbReference type="STRING" id="199890.A0A182PCE6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004601-RA">
        <property type="protein sequence ID" value="AEPI004601-PA"/>
        <property type="gene ID" value="AEPI004601"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004601"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16164">
        <property type="entry name" value="OCRE_VG5Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035624">
        <property type="entry name" value="AGGF1_OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="341"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="522"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004601-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="68697" checksum="BEE397EE3E6C0DD5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCM6</accession>
    <name>A0A182PCM6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spermatogenesis-associated protein 20-like TRX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCM6"/>
    <dbReference type="STRING" id="199890.A0A182PCM6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004681-RA">
        <property type="protein sequence ID" value="AEPI004681-PA"/>
        <property type="gene ID" value="AEPI004681"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004681"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="2">
        <location>
            <begin position="108"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004681-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="845" mass="95545" checksum="718F86EDE09EF5C1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCV0</accession>
    <name>A0A182PCV0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pseudouridine 5'-phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pseudouridine-5'-monophosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>psi-UMP + H2O = pseudouridine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10944"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17802"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="EC" id="3.1.3.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.96" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A182PCV0"/>
    <dbReference type="STRING" id="199890.A0A182PCV0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004755-RA">
        <property type="protein sequence ID" value="AEPI004755-PA"/>
        <property type="gene ID" value="AEPI004755"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004755"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990738">
        <property type="term" value="F:pseudouridine 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004755-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="320" mass="35793" checksum="44F247025AFA7B1C" modified="2016-09-07" version="1">MSRLFGSSSSSVLGTAGSKMSSFRKVTHCIFDMDGLLLDTENLYTQVTQSIAEPYGKTYTWEIKQTIMGLQRDEAAEAIVAALELPMTPAEYVQISTERINRVMEECQLMPDTEKIYENILRDLLKSYNSPYPWPTRMKVMGTTEQRTCSILVNDLKLPCSVDEFLARFRRDQLLHLGKAPLMQGAERLVRHLHKHNVPIALATSSGADSVEVKTKNHRELFELFGHKVMGSSDPEVKEGKPAPDIFLVAAARFPDRPAPDQCLVFEDAPNGVTAAIAAGMQAVMVPDPHIEEDQRKHATIVLKSLEEFRPEQFGLPAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDE8</accession>
    <name>A0A182PDE8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDE8"/>
    <dbReference type="STRING" id="199890.A0A182PDE8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004953-RA">
        <property type="protein sequence ID" value="AEPI004953-PA"/>
        <property type="gene ID" value="AEPI004953"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004953"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000027">
        <property type="entry name" value="Cysteine-rich venom protein kaouthin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.740">
        <property type="entry name" value="Crisp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042076">
        <property type="entry name" value="Crisp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013871">
        <property type="entry name" value="Cysteine_rich_secretory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08562">
        <property type="entry name" value="Crisp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57546">
        <property type="entry name" value="Crisp domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131239" description="SCP domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="4">
        <location>
            <begin position="50"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004953-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="275" mass="31349" checksum="2E6C6603B58D435F" modified="2016-09-07" version="1">MVRPAGGLLLFAVLLFACWFDLSDGWRYDRVPRLYGDKVPTKAISPRLRKVQRRIVMLHDSYRTKVVPPAANMLNMKWHHGAARSAQKWANQCRVLAHDTPKGRWIDNFGACGQNIFVSTHRVPWMFALQTWFLERQNFTYGSTRNDLDSVGHYTQMVWAATHKVGCGLTKCSKGGPRGKPFYNYVCNYCPIGNHEEKLGLPYKRGRPCGSCLPSCLSRRIKLCTNSCNTADLWANCRDLYRTWPGWLCNTATPEGLERQRNCAATCTCQGKIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDX0</accession>
    <name>A0A182PDX0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDX0"/>
    <dbReference type="STRING" id="199890.A0A182PDX0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005125-RA">
        <property type="protein sequence ID" value="AEPI005125-PA"/>
        <property type="gene ID" value="AEPI005125"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005125"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005125-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="392" mass="43818" checksum="35A2D3C8754FEA05" modified="2016-09-07" version="1">MSSKSAFHSCSFAPSIDHKESGKVFEIEQCMYNLSEDFFRQTTLRESIAPVENDMEEITPEVIREEETPDNATAAARYVHHIAEILERPISDDMMKKLCFSEMLLVCDGSDTIVGGAAINVSLIAEEVLAAFSSTRLTILGRSAAESELMSFADRNCRPLQERKCETLISGTMRQEKQIQLYFDEAHSVTAYRQESNGLHTESFHGLLSGPERGAEDVDTNLRPTILPDGLQLLLLRYLVLSNFVGEICSQTIDIQGRVGNCIHKITAAIPVPKQLRPGASIKEVRKTTWYSDGTEAEESVSHYDSATGRLLRHGWNSSNYILIENPIGMATPMAVKQLEQNMKDYVQNLTGLIKNRASVKELIDRTDCTAKEIDQCSRIVNPVLRDIINEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE54</accession>
    <name>A0A182PE54_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18 19 20">Poly [ADP-ribose] polymerase</fullName>
            <ecNumber evidence="4 19">2.4.2.30</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:54424"/>
            <dbReference type="Rhea" id="RHEA-COMP:9867"/>
            <dbReference type="Rhea" id="RHEA-COMP:13832"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:58224"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15089"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142540"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="4 19"/>
    <dbReference type="AlphaFoldDB" id="A0A182PE54"/>
    <dbReference type="STRING" id="199890.A0A182PE54"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005209-RA">
        <property type="protein sequence ID" value="AEPI005209-PA"/>
        <property type="gene ID" value="AEPI005209"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005209"/>
    <dbReference type="Proteomes" id="UP000075885">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0140807">
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        <property type="term" value="F:nucleotidyltransferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006302">
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    <dbReference type="GO" id="GO:0070212">
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    <dbReference type="Gene3D" id="1.20.142.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038650">
        <property type="entry name" value="PADR1_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008288">
        <property type="entry name" value="PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049296">
        <property type="entry name" value="PARP1-like_PADR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012982">
        <property type="entry name" value="PARP1-like_PADR1_Zn_ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21728">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Zn_ribbon_PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00347">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 19 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 19 20" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="23">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PARP-type" evidence="23">
        <location>
            <begin position="116"/>
            <end position="205"/>
        </location>
    </feature>
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        <location>
            <begin position="384"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="27">
        <location>
            <begin position="529"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="26">
        <location>
            <begin position="649"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="25">
        <location>
            <begin position="777"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="937"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00071874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005209-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1001" mass="113426" checksum="F0A725CA91D75B08" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PES3</accession>
    <name>A0A182PES3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PES3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005428-RA">
        <property type="protein sequence ID" value="AEPI005428-PA"/>
        <property type="gene ID" value="AEPI005428"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005428"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005428-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="125" mass="14189" checksum="C8F4060DE180D621" modified="2016-09-07" version="1">MKEKVFCVLIASFNLLAMVYTVTARNLHITMSGQYGASRTKEISLIRLFQMFLYAQLVFALMMVVYGYRFFDTVNVPILVKLYFSIMFIVCATELIIVSYTIDALNKKQNTAEGLVVYMPVGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEY8</accession>
    <name>A0A182PEY8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Diacylglycerol kinase</fullName>
            <shortName evidence="12">DAG kinase</shortName>
            <ecNumber evidence="12">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A182PEY8"/>
    <dbReference type="STRING" id="199890.A0A182PEY8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005493-RA">
        <property type="protein sequence ID" value="AEPI005493-PA"/>
        <property type="gene ID" value="AEPI005493"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005493"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20851">
        <property type="entry name" value="C1_DGK_typeI_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20845">
        <property type="entry name" value="C1_DGKbeta_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000017">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000013">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000016">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000003">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047471">
        <property type="entry name" value="C1_DGKbeta-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF48">
        <property type="entry name" value="DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="156"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="15">
        <location>
            <begin position="253"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="435"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="561"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005493-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="805" mass="88324" checksum="9726371A73690CDD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFM7</accession>
    <name>A0A182PFM7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small integral membrane protein 12</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMIM12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PFM7"/>
    <dbReference type="STRING" id="199890.A0A182PFM7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005734-RA">
        <property type="protein sequence ID" value="AEPI005734-PA"/>
        <property type="gene ID" value="AEPI005734"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005734"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031933">
        <property type="entry name" value="UPF0767"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28599">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28599:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15990">
        <property type="entry name" value="UPF0767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005734-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10001" checksum="014A36059826B56F" modified="2016-09-07" version="1">MWPLIMQFLRSNAAYITLPIATLVGVIGYNIESLLSDKYTPYSPSIQEKRAERITDDERLKSAAEVEKLVYRENVLGRNLSPSLEKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFT2</accession>
    <name>A0A182PFT2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Suppressor APC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PFT2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005791-RA">
        <property type="protein sequence ID" value="AEPI005791-PA"/>
        <property type="gene ID" value="AEPI005791"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005791"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026828">
        <property type="entry name" value="SAPC2_1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057953">
        <property type="entry name" value="SAPC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907">
        <property type="entry name" value="FI14130P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907:SF2">
        <property type="entry name" value="SUPPRESSOR APC DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25825">
        <property type="entry name" value="SAPC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11414">
        <property type="entry name" value="Suppressor_APC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor APC" evidence="2">
        <location>
            <begin position="137"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="305"/>
        </location>
    </feature>
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            <end position="383"/>
        </location>
    </feature>
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            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="650"/>
        </location>
    </feature>
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            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="304"/>
        </location>
    </feature>
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        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005791-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="705" mass="77719" checksum="A04AB08C0F61091A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PG26</accession>
    <name>A0A182PG26_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PG26"/>
    <dbReference type="STRING" id="199890.A0A182PG26"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005885-RA">
        <property type="protein sequence ID" value="AEPI005885-PA"/>
        <property type="gene ID" value="AEPI005885"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005885"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF176">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007950993" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="23"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="610"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005885-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="661" mass="75152" checksum="DABB3A4A6869225A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PG89</accession>
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        <recommendedName>
            <fullName evidence="5">Protein with signal anchor</fullName>
        </recommendedName>
    </protein>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PG89"/>
    <dbReference type="STRING" id="199890.A0A182PG89"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005948-RA">
        <property type="protein sequence ID" value="AEPI005948-PA"/>
        <property type="gene ID" value="AEPI005948"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005948"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005948-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42218" checksum="0BDB7B6B4798B553" modified="2016-09-07" version="1">MEVLREKLAKMAGGIRQAVGWFKAGGIVSSMVLIYVLHMLWPDFRPFSILFVIAIGFLWDRPPVERPSPSLRTSPLGELCSKVWALRATRPIAMVVGSAVGILTYGYLVCYVLPLWLSLALAGLVVFWDRCLFSISYTFSTVSSERGTMTEQEIDEFVPELTEVSRVLLQEVGEQGADTSGPLLDGCAVGTTPGARNSAEEDEEQYLRTLIPEASGNDFEAAELSGSSSDELFCPDEGPLVRMATGGSRTYAKPAERPIEFKSSHFNANSSSDSDDNMSRGLNFNDDIYDGVSRRSGSRQPQQQPQPQQQSAEAMLMMSATSLASNVLVDTVYKRLLDAGTMQSALGSTLQALRGQTVQEEDDDASTDADEDSEFEMLNSEELNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGQ6</accession>
    <name>A0A182PGQ6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGQ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006115-RA">
        <property type="protein sequence ID" value="AEPI006115-PA"/>
        <property type="gene ID" value="AEPI006115"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006115"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF13">
        <property type="entry name" value="HDC01644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006115-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="162" mass="18547" checksum="9DF3F0957BE880D8" modified="2016-09-07" version="1">MSPLVNGKYIYHDQEDGLLDERYLEALEGLKEAQAGAHIHSSVSEKSKTIPVPVFQKVGVPVPHPVPVAVPHYVKVYIPQPYPLQVNVEQPIKIPIYKVIPKVIEKPVPYTVEKPYPIEVEKPFPVEVLKKIEVPVPKPFPVPVTVYKHIMQNEKTHRNWHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGZ2</accession>
    <name>A0A182PGZ2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGZ2"/>
    <dbReference type="STRING" id="199890.A0A182PGZ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006201-RA">
        <property type="protein sequence ID" value="AEPI006201-PA"/>
        <property type="gene ID" value="AEPI006201"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006201"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="3"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006201-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="160" mass="18057" checksum="EC67A51DEBE2E051" modified="2016-09-07" version="1">VWFQNRRAKWRKKEHTKKGPGRPAHNAHPQSCSGEPIPPSELRAREKARRRKKIAKALERQARKLRAKGITVDLEALKAEYLSQHRNNSGSDTEDDDDNDDEDPIDVVGGAESGDEPEDCSMQRRESIDGDALDETGSDIPRNSIRPNPFSIESLLYNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHC8</accession>
    <name>A0A182PHC8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHC8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006337-RA">
        <property type="protein sequence ID" value="AEPI006337-PA"/>
        <property type="gene ID" value="AEPI006337"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006337"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006337-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="925" mass="102237" checksum="CE4A791FE5C5F643" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHJ6</accession>
    <name>A0A182PHJ6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHJ6"/>
    <dbReference type="STRING" id="199890.A0A182PHJ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006405-RA">
        <property type="protein sequence ID" value="AEPI006405-PA"/>
        <property type="gene ID" value="AEPI006405"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006405"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000270">
        <property type="entry name" value="Blast:Tyrosine-protein kinase Src-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000222">
        <property type="entry name" value="SH3 domain-containing protein Dlish"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="361"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006405-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="427" mass="46217" checksum="D3D0E3A2FD09DD58" modified="2016-09-07" version="1">MAFLCPVRIRRGKKKKPIGSDIDKDLSSSLGLNHGMGRITGSASIETLVRVGIEKEHGLSPDSKMVVLHDFTPCVDDELEVKRGQIVNILYRENDWVYVIGQDTRQEGFIPHSYCAPFNTQLADLAIKKKLPRDVSNMGPPGSGGGGVGGGSGAVPGATGVGLVGNGVGLTAADLTDSMLPDISMDVLDDSTGPGLLTNALKHSQASLSSEPDFLPFAKDPSGRYIVLYTFIARDENDVSVERGEFVTVLNREDPEWFWIVRSDGQEGFIPSGFVYPAENILQGQAGKQQQQQGGGVNSMGSIGNDMNSLQAMSGGNMTGGGGGGQHQQQQAQHQQQAQHQQQAQQQHQQQPGIGSDDLRYHGTELVMLYDYKAQAPDDLSVRRGDWIYADLNNQTVDGWLWAYAPKTRKYGFIPKAYARPPAMTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHX7</accession>
    <name>A0A182PHX7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHX7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006538-RA">
        <property type="protein sequence ID" value="AEPI006538-PA"/>
        <property type="gene ID" value="AEPI006538"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006538"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006538-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="334" mass="36678" checksum="FBCFE19A02E499A3" modified="2016-09-07" version="1">MSMLEAEKESVALASYNVAEHRLDYIKLGEGREYNYHYNDGVSSGYDKRKFYKRPQAFKQPYAFKNFATPVEQIATNEFHTHPQQTYMTQESLLPVYESHEKTVSYVPAEFAPSKPAAVQRESPYSLTQSTGPVSYTGTLAERVIQMIQLHHPPSVKNSSSVATSSSSSSSSSSSIGTGGTSTIHYQAPGVQYSQHPGSYQYFNAHPAPAEYELVRPISNFPPPRPYLAPTLTTTKAPYVAPFLQRTSTTTTTTTTTTTPAPPTKRPPYVAPGVTKDPLLSSVSLANQLKYTSTSRPASNRPASTSSNGNGSPLQPYEPEFDIDIRIDLRDDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI41</accession>
    <name>A0A182PI41_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein COX11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with CNNM4/ACDP4. Interacts with RANBP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PI41"/>
    <dbReference type="STRING" id="199890.A0A182PI41"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006603-RA">
        <property type="protein sequence ID" value="AEPI006603-PA"/>
        <property type="gene ID" value="AEPI006603"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006603"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005413">
        <property type="entry name" value="COX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006603-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="224" mass="25251" checksum="323FC99A43021253" modified="2016-09-07" version="1">TSIKKVLYKTDSPCLLGTPTRSFIGKGHDTDRNFKIRSTVYYVAAAGVLTVGLSYAAVPLYRMFCQAYSYGGTTSQGHDAEKVESMQKVKDRVIKVKFNADIGASMRWNFKPQQTEIKVVPGETALAFYSAKNPTDHPVIGISTYNVIPFEAGAYFNKIQCFCFEEQQLNPHEEVDLPVFFYIDPDFIEDPKMELVDSITLSYTFFESKDGMNIQMPVYAKKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIK8</accession>
    <name>A0A182PIK8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox protein unplugged</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIK8"/>
    <dbReference type="STRING" id="199890.A0A182PIK8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006770-RA">
        <property type="protein sequence ID" value="AEPI006770-PA"/>
        <property type="gene ID" value="AEPI006770"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006770"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051960">
        <property type="term" value="P:regulation of nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000360">
        <property type="entry name" value="Gastrulation brain homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042982">
        <property type="entry name" value="GBX-1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24334">
        <property type="entry name" value="HOMEOBOX PROTEIN GBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24334:SF0">
        <property type="entry name" value="HOMEOBOX PROTEIN UNPLUGGED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="331"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="333"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006770-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="550" mass="57516" checksum="15DB3663165DD0A5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIQ9</accession>
    <name>A0A182PIQ9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIQ9"/>
    <dbReference type="STRING" id="199890.A0A182PIQ9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006822-RA">
        <property type="protein sequence ID" value="AEPI006822-PA"/>
        <property type="gene ID" value="AEPI006822"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006822"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006822-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="171" mass="18751" checksum="97B409701FB13823" modified="2016-09-07" version="1">MVVAVGSAYITGNGYKILTKHSSHYFGNGANAIDSYQPLGIGAGYSEAGLVGYKSAQDGAYPANGYDYSDHYAYPKYKYDYGVQDAHTGDHKSQWEIRDGDVVKGGYTLYDADGTKRVVEYSSDKHHGFQAHVKRVGHAHHPQVYKTEHGISGGGYEEAEGYSYSNINQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIR8</accession>
    <name>A0A182PIR8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIR8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006831-RA">
        <property type="protein sequence ID" value="AEPI006831-PA"/>
        <property type="gene ID" value="AEPI006831"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006831"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131506" evidence="2">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006831-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="115" mass="13030" checksum="658BF4C15F7EC1F3" modified="2016-09-07" version="1">MFKLIGLILCLVIITTAYDYDDDDSKELYDPSKFEFEYGEKYHQTSDKKYESGEQDGDVVKEVKPSRKLNETVGDVEFTKNVPKANITTAVPDMTTTSMSKEQTTPKPIATTDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJM2</accession>
    <name>A0A182PJM2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJM2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007136-RA">
        <property type="protein sequence ID" value="AEPI007136-PA"/>
        <property type="gene ID" value="AEPI007136"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007136"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007136-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="245" mass="28109" checksum="9A9C7CA843D1CF90" modified="2016-09-07" version="1">MVYGRCPFLKAVRFEPYLIRPFEGKNGEILYFSNVRFEALLNNRLEIEEHYISKYVIVLEHKETCFQPFQLQLRGALMTTPNGDSTSPGSITAINATILGLYEKDYLFVFSCIQLDHNKLEYVWIFGRAGRFGGVGTEKVQKMFGHLLANMSTELKDLRRSHHELPFCTSIFWPTVFYGSGGVLVLLVLTAGIVCWKKHKQILLLRRQSCAECEYPSQELDMEERAMRRDITSAKTIAIMHGAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJQ0</accession>
    <name>A0A182PJQ0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB10 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJQ0"/>
    <dbReference type="STRING" id="199890.A0A182PJQ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007164-RA">
        <property type="protein sequence ID" value="AEPI007164-PA"/>
        <property type="gene ID" value="AEPI007164"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007164"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019377">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10249">
        <property type="entry name" value="NDUFB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007164-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="166" mass="19476" checksum="3C2F5A215DDB6CCA" modified="2016-09-07" version="1">MPEAPARNPLDSFLNAVQATIDGPVTWFREKIVEPNRQTYPWYHQKFRRVPSIDQCYTDDAVCIFEANQQFKRDKMVDNEILAILRQRFEDCVLYEQPDHERKCRSILDTYEKAAENWFIKYGDLGGYANAKTAYMKQKHRMIWERRHGPVGTGMKSVEGDAASEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK37</accession>
    <name>A0A182PK37_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PK37"/>
    <dbReference type="STRING" id="199890.A0A182PK37"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007303-RA">
        <property type="protein sequence ID" value="AEPI007303-PA"/>
        <property type="gene ID" value="AEPI007303"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007303"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007303-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="602" mass="67173" checksum="042A791161630CF6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK44</accession>
    <name>A0A182PK44_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PK44"/>
    <dbReference type="STRING" id="199890.A0A182PK44"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007310-RA">
        <property type="protein sequence ID" value="AEPI007310-PA"/>
        <property type="gene ID" value="AEPI007310"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007310"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007310-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="779" mass="86934" checksum="DF1C8FDDAE03B640" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKJ2</accession>
    <name>A0A182PKJ2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-sarcoglycan</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <location evidence="3">Sarcolemma</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sarcoglycan beta/delta/gamma/zeta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKJ2"/>
    <dbReference type="STRING" id="199890.A0A182PKJ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007459-RA">
        <property type="protein sequence ID" value="AEPI007459-PA"/>
        <property type="gene ID" value="AEPI007459"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007459"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016012">
        <property type="term" value="C:sarcoglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006875">
        <property type="entry name" value="Sarcoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027659">
        <property type="entry name" value="Sgcb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21142:SF2">
        <property type="entry name" value="BETA-SARCOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21142">
        <property type="entry name" value="SARCOGLYCANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04790">
        <property type="entry name" value="Sarcoglycan_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007459-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="287" mass="32244" checksum="DFA0DEF7E9725813" modified="2016-09-07" version="1">MRQVEQKYDLSKCRTYNEKSSFAFWIVLVLLFCLALGNLCLTLSITAILRIYRGMENIELIQDADTIKFYGNIDFDRVYKEDGLLESFYEEPLELTGDDGDVSINLVNRNGQSHEKIQLTRTGSFLKGINHFDVKDPVTGRQVFATSRPHYNMPQGAAVLQTHLVNSGRIASPINDTLMLQTRSKLTLKGTEGIRMEAKELLWSADQNIFLKSDNGSTMLVGGNGVWVNVNNLPVVKSEHGVRTGSSNQYKLCVCYPQGRIFRMAVPKTHNARVNCAHYSGKENPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKL4</accession>
    <name>A0A182PKL4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SURF6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKL4"/>
    <dbReference type="STRING" id="199890.A0A182PKL4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007481-RA">
        <property type="protein sequence ID" value="AEPI007481-PA"/>
        <property type="gene ID" value="AEPI007481"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007481"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="95"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007481-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="290" mass="34044" checksum="7E3592037860AC28" modified="2016-09-07" version="1">MGKKAASELQTRLQAINDEMEFYVQLFNIPESKQDDGDESDYLLDTDEVPKKPLMKRTKATEEDKTFEMEVKKNKITAKHIGRKGKTSTDPQKIERKKLKKEKKMKKKLKNISMAVIKQEQQRTKLIEHKPLEVKQEKKTGRMFNAEDKIVFSKVQLDESDVQKKGIETDTKKLLKKVLDNKKQLAELKESGDIEKYAEIKKKQAWEKALAKTAGQKVRDDPELLAKKVIQRKKQIKKSKEQWKEREQKIEQKQKQRQKERTANIKERAQKKKNTKLKKMAKKGRVIPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKP9</accession>
    <name>A0A182PKP9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKP9"/>
    <dbReference type="STRING" id="199890.A0A182PKP9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007516-RA">
        <property type="protein sequence ID" value="AEPI007516-PA"/>
        <property type="gene ID" value="AEPI007516"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007516"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012314">
        <property type="entry name" value="Pept_M12B_GON-ADAMTSs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF278">
        <property type="entry name" value="ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08685">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51046">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GON" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007516-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1206" mass="136414" checksum="006C1F0AF1E393A4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKU1</accession>
    <name>A0A182PKU1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKU1"/>
    <dbReference type="STRING" id="199890.A0A182PKU1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007558-RA">
        <property type="protein sequence ID" value="AEPI007558-PA"/>
        <property type="gene ID" value="AEPI007558"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007558"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.40">
        <property type="entry name" value="Formin, diaphanous GTPase-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044933">
        <property type="entry name" value="DIA_GBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007558-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="124" mass="13223" checksum="4EE0A03A46EAE9EF" modified="2016-09-07" version="1">MSKHDRVKSGGFLDTLLGRPHKKLGRHGGSGVYGNGPNGAGGNGSGGYGSYGSLNGGRPLSGPDADLVSLIEPNETQRLSEAEVNKLFLDILEDMNIPKDKRDPLLGKPLEEKRKMIDMHVKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL26</accession>
    <name>A0A182PL26_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PL26"/>
    <dbReference type="STRING" id="199890.A0A182PL26"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007643-RA">
        <property type="protein sequence ID" value="AEPI007643-PA"/>
        <property type="gene ID" value="AEPI007643"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007643"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02996">
        <property type="entry name" value="PDI_a_ERp44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03072">
        <property type="entry name" value="PDI_b'_ERp44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03070">
        <property type="entry name" value="PDI_b_ERp44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000051">
        <property type="entry name" value="endoplasmic reticulum resident protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000074">
        <property type="entry name" value="endoplasmic reticulum resident protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052643">
        <property type="entry name" value="ERP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041870">
        <property type="entry name" value="ERp44_PDI_b_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041862">
        <property type="entry name" value="ERp44_PDI_b_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF1">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007643-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="392" mass="45169" checksum="4D9BF7A2D289A9B8" modified="2016-09-07" version="1">MVVYMFYNPSNSGAVQLNSENIDMTLASNELVLINFYADWCRFSNILQPIFDEAAEKVQAAFPEPGKVVMGKVDCDRESSVASRFHITKYPTLKVLRNGQPTKREYRGARTVEAFTEFIRKQLEDPIREFQNIKDLEQLDSKKRIVVGYFDRRDMPEYNTFRRVATNLKEDCQFHVGFGDVVQALHPPGHPIIVFRPDVAVSNENDETYMGDLRSFDELNIWVQEKCVPLVREITFENAEELTEEGLPFLILFYAPGDLESIKDYKAIVQLDLISEKQNVNFLTADGKRFAHPLHHLGKTQADLPLIAIDSFRHMYLFPNFKDIYVPGKLKQFLNDLYSGKLHREFHYGPEKEAIADTNAIEDGKNPTTPPESTFKKLGPSKNRYTLLRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL64</accession>
    <name>A0A182PL64_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PL64"/>
    <dbReference type="STRING" id="199890.A0A182PL64"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007681-RA">
        <property type="protein sequence ID" value="AEPI007681-PA"/>
        <property type="gene ID" value="AEPI007681"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007681"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002046">
        <property type="entry name" value="Axonemal dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF7">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="268"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="513"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007681-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="607" mass="70714" checksum="F59B77793371DDC5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLU6</accession>
    <name>A0A182PLU6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLU6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007918-RA">
        <property type="protein sequence ID" value="AEPI007918-PA"/>
        <property type="gene ID" value="AEPI007918"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007918"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
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        <location>
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            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131642" description="Chitin-binding type-2 domain-containing protein" evidence="7">
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            <begin position="22"/>
            <end position="625"/>
        </location>
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            <end position="117"/>
        </location>
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            <end position="177"/>
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            <end position="236"/>
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            <end position="321"/>
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            <end position="405"/>
        </location>
    </feature>
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            <end position="465"/>
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            <end position="524"/>
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            <end position="542"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007918-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="625" mass="68581" checksum="A91A96156DE2FCA6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM21</accession>
    <name>A0A182PM21_9DIPT</name>
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        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
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        <property type="entry name" value="anillin isoform X1"/>
        <property type="match status" value="1"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007993-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMF2</accession>
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        <submittedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
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    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="199890.A0A182PMF2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008125-RA">
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        <property type="gene ID" value="AEPI008125"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008125"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042051">
        <property type="term" value="P:compound eye photoreceptor development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10536">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SMYD4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF7">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008125-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="667" mass="76378" checksum="0A1961CCD097C38C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMJ4</accession>
    <name>A0A182PMJ4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sushi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMJ4"/>
    <dbReference type="STRING" id="199890.A0A182PMJ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008168-RA">
        <property type="protein sequence ID" value="AEPI008168-PA"/>
        <property type="gene ID" value="AEPI008168"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008168"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="3">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008168-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="75" mass="8361" checksum="60B52A6974311BA5" modified="2016-09-07" version="1">MATGEPYEDCEQPPEIAHGSARLTVDDNEEYVTAHYTCKSGYRLQEPQLAQLRCSIETDEWESTKLPACVPACAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMK0</accession>
    <name>A0A182PMK0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TAFH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PMK0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008174-RA">
        <property type="protein sequence ID" value="AEPI008174-PA"/>
        <property type="gene ID" value="AEPI008174"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008174"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1110:FF:000004">
        <property type="entry name" value="TBP-associated factor 4, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000015">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1110">
        <property type="entry name" value="TAFH/NHR1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037249">
        <property type="entry name" value="TAFH/NHR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003894">
        <property type="entry name" value="TAFH_NHR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07531">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00549">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158553">
        <property type="entry name" value="TAFH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51119">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFH" evidence="8">
        <location>
            <begin position="607"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1288"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1215"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008174-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1615" mass="168185" checksum="FAD0D276CE4DCD67" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PML8</accession>
    <name>A0A182PML8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alkaline phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
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            <begin position="1"/>
            <end position="19"/>
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            <begin position="20"/>
            <end position="560"/>
        </location>
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            <position position="132"/>
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        <location>
            <position position="88"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="88"/>
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        <ligand>
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            <label>2</label>
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        <ligand>
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        <ligand>
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            <position position="349"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="560" mass="61700" checksum="027E0316C6CCD2F7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMY2</accession>
    <name>A0A182PMY2_9DIPT</name>
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        <recommendedName>
            <fullName evidence="1">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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        </source>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNQ8</accession>
    <name>A0A182PNQ8_9DIPT</name>
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        <recommendedName>
            <fullName evidence="4">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Howell P."/>
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                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
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                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
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                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
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        <property type="gene ID" value="AEPI008587"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008587"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
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        <property type="entry name" value="O2_lipid_transport_reg"/>
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        <property type="entry name" value="DROP DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131600" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="1236"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="621"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="746"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="864"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="936"/>
            <end position="954"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="969"/>
            <end position="991"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="4">
        <location>
            <begin position="444"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008587-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1236" mass="138873" checksum="6B472C120336D802" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNW6</accession>
    <name>A0A182PNW6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein sprouty</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sprouty family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNW6"/>
    <dbReference type="STRING" id="199890.A0A182PNW6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008645-RA">
        <property type="protein sequence ID" value="AEPI008645-PA"/>
        <property type="gene ID" value="AEPI008645"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008645"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007875">
        <property type="entry name" value="Sprouty"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051192">
        <property type="entry name" value="Sprouty_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365:SF7">
        <property type="entry name" value="PROTEIN SPROUTY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365">
        <property type="entry name" value="SPROUTY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05210">
        <property type="entry name" value="Sprouty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51227">
        <property type="entry name" value="SPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008645-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="60997" checksum="18838B730EDAD4AC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNY6</accession>
    <name>A0A182PNY6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasmic vesicle</location>
            <location evidence="1 12">COPI-coated vesicle membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="12">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNY6"/>
    <dbReference type="STRING" id="199890.A0A182PNY6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008665-RA">
        <property type="protein sequence ID" value="AEPI008665-PA"/>
        <property type="gene ID" value="AEPI008665"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008665"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000008">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="14">
        <location>
            <begin position="320"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="15">
        <location>
            <begin position="596"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008665-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="958" mass="107612" checksum="F78AD34BF71A4A73" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP13</accession>
    <name>A0A182PP13_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="6 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="6 14"/>
    <dbReference type="AlphaFoldDB" id="A0A182PP13"/>
    <dbReference type="STRING" id="199890.A0A182PP13"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008692-RA">
        <property type="protein sequence ID" value="AEPI008692-PA"/>
        <property type="gene ID" value="AEPI008692"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008692"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000001">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008692-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="409" mass="45444" checksum="6C24CC05548C85AD" modified="2016-09-07" version="1">MVEKVGRKLYVRLLVAFLGGLATGVLLVVSMAQLKMRLIALQESSMVLPQARTSAGRDDFPPLKNDNLLRAARGEPVDRVPVWVMRQAGRYLPEFQEVRAKHDFFTVCRTPELACEVTMQPLRRFDLDASIIFSDILVIPQALGITVEMKPGVGPVLPEPLVGPADLERLNQTGTIERLKYVGEAITMMRRMLEGKVPLFGFTGAPWTLMGYMIEGGGSKTMSKAKAWLADYPEASQKLLDILTDQVVDYLVMQVKAGAQMLQVFESSADHLSKEQFLSVSLPCLKRIRVDVLRKLADEDVPAVPMVLFAKGAMHSLAEQAQTGYEVIGLDWTIDPEEARKQVGPNVTLQGNLDPQDMYKPPDELRELVLTMVRKFGKHRYIANLGHGITPQTPIESMNVLVQAVHDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPH6</accession>
    <name>A0A182PPH6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPH6"/>
    <dbReference type="STRING" id="199890.A0A182PPH6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008855-RA">
        <property type="protein sequence ID" value="AEPI008855-PA"/>
        <property type="gene ID" value="AEPI008855"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008855"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000611">
        <property type="entry name" value="Capricious, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF168">
        <property type="entry name" value="GH22922P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="10">
        <location>
            <begin position="402"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008855-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="566" mass="61720" checksum="18F586C74856FB56" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPM8</accession>
    <name>A0A182PPM8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPM8"/>
    <dbReference type="STRING" id="199890.A0A182PPM8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008907-RA">
        <property type="protein sequence ID" value="AEPI008907-PA"/>
        <property type="gene ID" value="AEPI008907"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008907"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF220">
        <property type="entry name" value="LD41874P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="116"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008907-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="318" mass="37265" checksum="BFADB18FD4FE44E9" modified="2016-09-07" version="1">MRVPTMLSDVEELPSVQLGDYVLRFELEDLTPFGKEVAKNELRETPEIRAAAIEELRTLLKGVEDLVVPLDNDDWMIRFLRPCKFYAKSACELIQRYYQFKVKHFDMYNELMPSKEANIFKQNILAVFPNRDQLGRRVLLLELGKTWKHKEVTLDEVFKGCVLFLEAAMLEPETQVHGAVVIFDMDGLTLQQAWQFTPPFAKRIVDWLQDAVPLRIKGIHIINQPKIFNMVFALFKPILREKLRNRIIFHGTDRESLYSHISKECLPAVYGGTVNAPRVLGDQWYELLLKCDNEYKEINNYGYIKQLEEQRNKKNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPY8</accession>
    <name>A0A182PPY8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-related protein Rab-1A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPY8"/>
    <dbReference type="STRING" id="199890.A0A182PPY8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009018-RA">
        <property type="protein sequence ID" value="AEPI009018-PA"/>
        <property type="gene ID" value="AEPI009018"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009018"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009018-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22383" checksum="E3F190D1F356A81B" modified="2016-09-07" version="1">MSPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIDLDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDCTDHDSFENVKQWLEEIERYACDNVNKLLVGNKCDLQTKKRVDTTTAMELANQLGIPFLETSAKNATNVEQAFMTMAAEIKNRVGPPSSAADPPSAVKIDKGRNVEAKSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQJ0</accession>
    <name>A0A182PQJ0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQJ0"/>
    <dbReference type="STRING" id="199890.A0A182PQJ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009221-RA">
        <property type="protein sequence ID" value="AEPI009221-PA"/>
        <property type="gene ID" value="AEPI009221"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009221"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000090">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009221-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="463" mass="50423" checksum="88E9674BE849DCCC" modified="2016-09-07" version="1">MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSTEPPYNEARFEEIKKEVSSYIKKIGYNPAAVAFVPISGWHGDNMLEPSTKMPWFKGWAIERKEGKADGKCLIEALDAILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGTVVVFAPVNLTTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRGYVAGDSKNAPPKGAADFTAQVIVLNHPGQISNGYTPVLDCHTAHIACKFAEIKEKVDRRSGKSTEDNPKFIKSGDAAIVNLVPSKPLCVESFQEFPPLGRFAVRDMRQTVAVGVIKAVNFKDAAGGKVTKAAEKATKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQP5</accession>
    <name>A0A182PQP5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQP5"/>
    <dbReference type="STRING" id="199890.A0A182PQP5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009276-RA">
        <property type="protein sequence ID" value="AEPI009276-PA"/>
        <property type="gene ID" value="AEPI009276"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009276"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131747" description="Fibrinogen C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="142"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009276-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="319" mass="35924" checksum="DFEBC1A89F5AAA81" modified="2016-09-07" version="1">MASSRVLASVLLLLGVVSKSYETRLNAGNPIKTVETVTESSLSYAQLGQRINKLKLHIDQSIEYLWNRLEPLLESVQNVKQTSCGSDLPQETSVLQEKLHALLHTVSSGKECMQLAGLQSDIKAIREGQRQVSERLFNVSASREIKVARLKYQLLEASLGVKLYRYNPDGKGAFIVKSCSASNHLYGDGWIVFQQRYDGSISFNRTWAAYREGFGEWGGEYWLGLEKLHRILSSGPRFELLIELEGPRGVTAFQHYNEFLIGDESENYELKQLGSSEGTAGDSLQILKGNNFTTYDHYATHNCPTAFWGGWWFDNCNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQP7</accession>
    <name>A0A182PQP7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BK channel</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQP7"/>
    <dbReference type="STRING" id="199890.A0A182PQP7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009278-RA">
        <property type="protein sequence ID" value="AEPI009278-PA"/>
        <property type="gene ID" value="AEPI009278"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009278"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131623" description="BK channel" evidence="15">
        <location>
            <begin position="20"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="3"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009278-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="283" mass="32060" checksum="CAEA06A79BCDA288" modified="2016-09-07" version="1">VVLVFILSIASLIIYFIDASNEEVERCQKWSNNITQQIDLAFNIFFMVYFFIRQKNGTPKVRHCGGGAVPCHLPHIERLSKALPPLRTGYLIRFFIAASDKLWFMLEMYSFVDYFTIPPSFVSIYLDRTWIGLRFLRALRLMTVPDILQYLNILKTSSSIRLAQLVSIFISVWLTAAGIIHLLENSGDPLEFNNPQQLSYWTCVYFLIVTMSTVGYGDVYCETVLGRTFLVFFLLVGLAMFASSIPEIIELVGSGSKYGGELKREQGKSCAQLAPSAQQVEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRC2</accession>
    <name>A0A182PRC2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRC2"/>
    <dbReference type="STRING" id="199890.A0A182PRC2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009506-RA">
        <property type="protein sequence ID" value="AEPI009506-PA"/>
        <property type="gene ID" value="AEPI009506"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009506"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF128">
        <property type="entry name" value="GLUCOSE TRANSPORTER TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="119"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009506-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="350" mass="39317" checksum="808CA7E26068548D" modified="2016-09-07" version="1">MSYGDISYGLQKQVSVMSMNLSAKLDDLQRGDRHLETTVALCEIRTQLQELTKSVESCQTEVSEVKRDMVAIKHELDTVQQVKEEIEELREYVDRLEEHTHRRKLRLLEQGLTFFLTYAIFAAVLGMLQFGYNTGVINAPEVNIENFMKDVYKDRYGEDISEEFIQQLYSVAVSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGISGACLMGFTKMSHSYEMLFLGRFIIGVNCALRRLRASNQVEEDIEEMRAEERAQQSESSISTIELICSPTLRAPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSIPLMDRTGRRTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRP8</accession>
    <name>A0A182PRP8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">FERM, ARHGEF and pleckstrin domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">FERM, RhoGEF and pleckstrin domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Moesin/ezrin/radixin homolog 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
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    <sequence length="5307" mass="588549" checksum="667FE8630854B413" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRZ2</accession>
    <name>A0A182PRZ2_9DIPT</name>
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        <recommendedName>
            <fullName evidence="12">Trafficking protein particle complex subunit 2-like protein</fullName>
            <ecNumber evidence="7">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
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            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the deoxyhypusine synthase family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="SNARE-like"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="1"/>
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        </source>
    </evidence>
    <sequence length="481" mass="53522" checksum="F0EC6B94B5FA12B8" modified="2016-09-07" version="1">MEQSKEPTVAKEAVLQESSKLPEDTPKVRGYDWNEGYSYERLFSTYVHSGFQATNLGQAIEEVNKMLAARRVPLPEDKLDVYEEDEFIKRQSSCTIFLGYTSNMVSAGVRETIRFLAQHRLVDCIVTTAGGVEEDLIKCLAPTFLGSFELAGRELRERGINRIGNLLVPNENYCKFENWVIPILDEMLEEQKSKGTLWTPSKVITRLGEKINDESSIYYWAAKNRIPVFSPALTDGSLGDMMYFHSFRNPGLVVDIVSDLRRLNTMAVKAVHSGIIIVGGGVIKHHICNANLMRNGADYSVFVNTASEYDGSDSGARPDEAVSWGKIKKDATPVKVYAEASLMCACVAIIGKDNAPLYIATANVDKEIALQYQVHASLDVIDERCATNQKAAADGRELYLGSLISTEQYKIYGYVTNTKIKFLIVIDASSTSSFRENEVRAMFRNLHNLYTDAVCNPFYTPGEPLTSASFDRAVRGIISAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSE1</accession>
    <name>A0A182PSE1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PSE1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009876-RA">
        <property type="protein sequence ID" value="AEPI009876-PA"/>
        <property type="gene ID" value="AEPI009876"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009876"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000144">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131815" description="UDP-glycosyltransferases domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1518"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1567"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="2052"/>
            <end position="2071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009876-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2087" mass="237279" checksum="0560748C8D9A5EE0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSM0</accession>
    <name>A0A182PSM0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
            <location evidence="9">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSM0"/>
    <dbReference type="STRING" id="199890.A0A182PSM0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009955-RA">
        <property type="protein sequence ID" value="AEPI009955-PA"/>
        <property type="gene ID" value="AEPI009955"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009955"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.20:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009955-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="871" mass="100627" checksum="B62519A735DEA9A3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PT94</accession>
    <name>A0A182PT94_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PT94"/>
    <dbReference type="STRING" id="199890.A0A182PT94"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010180-RA">
        <property type="protein sequence ID" value="AEPI010180-PA"/>
        <property type="gene ID" value="AEPI010180"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010180"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000117">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase makorin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="305"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="129"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010180-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="503" mass="56072" checksum="B1C67CA5F626FC18" modified="2016-09-07" version="1">MEKGKDAAVLPVVVPLDNAAAAQIVCRFYQIGACRFGTSCRFIHPVPDEPTVPTLGSSCASSNSSSSSSGGSSSSIYQSCTSKIDSPVAGSAAVTKPTGGAPNGKTLSKSTIDPSRWIDAPVFVPKANLTVSQQQPATQPDRKSRRKAQLRKAVPDELEEEEEDELEEEEVEELDEDERNNEADNEEEEEEEEEQNEQEQAGAVGGRSDSALLSYANVVTMNNNHNGTGELVSEVRLCIHFEKHGLCPLADCVHLHGELCELCHRYCLDPRDTEQQRRHNAACIREHELEMEHAFAVQRSRDKSCGICLEVVMEKRAREQRFGILPNCKHTFCLSCIRTWRKATNFANKIKRGCPTCRIPSDFVCPSFVWVEAGEEKDRLIENYKQACNNTDCMHFKKGAANCPFGNKCFYRHALPSGELVDLGAPSRRRNPHRGRSRDMSTLRLQEIFASLLAPRGWAMEEFMTTLFSDDLEDDSDDDLDIYTPWAGDSSDWEDDLLDDGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU42</accession>
    <name>A0A182PU42_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PU42"/>
    <dbReference type="STRING" id="199890.A0A182PU42"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010478-RA">
        <property type="protein sequence ID" value="AEPI010478-PA"/>
        <property type="gene ID" value="AEPI010478"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010478"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010478-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="342" mass="36694" checksum="980AD47BD18910DD" modified="2016-09-07" version="1">MSYYASTLFGPLQQQPNAQPRPLKRQRLMAPSRMGMTPKMNGAGPILGHATHVQQQQQQQQQQQVLSQQQQQQQQQQQQQQQMHLVAHSQQLQQQMQAVATASPVAGGGCNLGSYYTAPAGNIGSSNGVQLQVPNGCIGSNGYINNNNCLMNGVELNGGAGGVLGGGCNMSSYTNGQHVVGPFKTYSNPDTLICGNCRELFTDLTELLDHKRSYCKLRFTCKCLSTSPVQKVYPTPQAKLVCVACKDSFTNPWDLMVHAQAAHMVNIYELGESVPGEDGKVPPVGGGGDRTASSTPTMPCSPPALELGKLNGTVAAVNNLMANGIHELEDDKNDHAEVSTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU78</accession>
    <name>A0A182PU78_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PU78"/>
    <dbReference type="STRING" id="199890.A0A182PU78"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010514-RA">
        <property type="protein sequence ID" value="AEPI010514-PA"/>
        <property type="gene ID" value="AEPI010514"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010514"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010514-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15274" checksum="CEB1D686BDD9AED7" modified="2016-09-07" version="1">MGALHMKEHPDYKYRPRRKPKPLVKSPTPSGTTHPNGAGPVSAKETVPQSQSPVGRTSFSPTQLTTPVGLPPGIFPSYHFAYDLHQKAFWNLYGPHLLSSVVPSAYAVPPHAALPLSYIKPPKSSPPSPIAPPSPIQSSNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU86</accession>
    <name>A0A182PU86_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCMBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU86"/>
    <dbReference type="STRING" id="199890.A0A182PU86"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010522-RA">
        <property type="protein sequence ID" value="AEPI010522-PA"/>
        <property type="gene ID" value="AEPI010522"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010522"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010522-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="621" mass="69138" checksum="0D4A627D303BF9BB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUA6</accession>
    <name>A0A182PUA6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUA6"/>
    <dbReference type="STRING" id="199890.A0A182PUA6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010542-RA">
        <property type="protein sequence ID" value="AEPI010542-PA"/>
        <property type="gene ID" value="AEPI010542"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010542"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048371">
        <property type="entry name" value="ZNHIT3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21373">
        <property type="entry name" value="ZNHIT3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010542-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="160" mass="18387" checksum="1B0A47B64F3F8D0F" modified="2016-09-07" version="1">MKMPGVCEICQVNERKYRCKTCSVHYCSVVCYKKHQEQPCQPPPQPKDTGDDADKQAVEGKGNIPKKTILFSTVDTVPAEKLELLGQSEHLKNLLYNPHLRQLLKEVDSGRDGMNAIKVAMMEPLFVEFADECLRIVEPPEDEAEYRLDELVFTNRQHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUC1</accession>
    <name>A0A182PUC1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BUB1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PUC1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010557-RA">
        <property type="protein sequence ID" value="AEPI010557-PA"/>
        <property type="gene ID" value="AEPI010557"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010557"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="875"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="970"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1219"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="461"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="586"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="877"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1059"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1071"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1138"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1162"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1177"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1219"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1258"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="1476"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010557-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1660" mass="188150" checksum="E61485147FE7266D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVL2</accession>
    <name>A0A182PVL2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVL2"/>
    <dbReference type="STRING" id="199890.A0A182PVL2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010999-RA">
        <property type="protein sequence ID" value="AEPI010999-PA"/>
        <property type="gene ID" value="AEPI010999"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010999"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005000">
        <property type="term" value="F:vasopressin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15197">
        <property type="entry name" value="7tmA_NPSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000188">
        <property type="entry name" value="Neuropeptide S receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052665">
        <property type="entry name" value="Neuropeptide-GPCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001817">
        <property type="entry name" value="Vasoprsn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224">
        <property type="entry name" value="CARDIOACCELERATORY PEPTIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224:SF6">
        <property type="entry name" value="CARDIOACCELERATORY PEPTIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00896">
        <property type="entry name" value="VASOPRESSINR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU046427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010999-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="393" mass="43845" checksum="D10AC50DE60BE213" modified="2016-09-07" version="1">SFQTEQFAVLWILFVVIVLGNTAVLVTLFLNKNRKSRMNFFIKQLAIADLSVGLLSVLTDIVQRITISWLAGNVACKLIRFVQVWVTYASTYVLVALSIDRYDAITHPMNFSGCWKRARRLVGAAWGFSAVFSSPMFYLYEERTIQDQLQCWIDLGDSFRWQVYMCWVAASLFVIPAFIISACYVIIIRTIWSKGSMLGPAPATGGSGPNGAKHRPLRNGGCAELASRRASSRGIIPRAKVKTVKMTIVIVIVFVLCWSPYIVFDLLQVFEQIPKTQTNIAIATFIQSLAPLNSAANPLIYCLFSTHFVRTLKRLPPFRWLLSSPFCCASEEDRTERGRCGTISNGNRNLRNQHSSSSSMRTLTTSLTVSTRRPTATISTRGTNGMAAGRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVY8</accession>
    <name>A0A182PVY8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein detached</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Component of the dystrophin associated protein complex (DAPC). Interacts with Dg, via the Dg WW domain binding sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVY8"/>
    <dbReference type="STRING" id="199890.A0A182PVY8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011125-RA">
        <property type="protein sequence ID" value="AEPI011125-PA"/>
        <property type="gene ID" value="AEPI011125"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011125"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
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    <proteinExistence type="predicted"/>
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    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
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    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="829"/>
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        </source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00083840"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011125-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1059" mass="119451" checksum="C73F79AA34561974" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW27</accession>
    <name>A0A182PW27_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4794 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AEPI011164"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI011164"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131901" description="DUF4794 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011164-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="18215" checksum="B2EDD9055C8AECEC" modified="2016-09-07" version="1">MALSFISSISLLLVASVLCSSTEAGLAASYLAAPPVAAAYTVAAPIVPAQGVLRTAYSQVVGPDSLPGVFDARNAAAPSAATTLQRAFVTAFGSPEGIRLVGVGAGQAFEGAPTNVEIARAAPGGQMEGAAQQGRSAATPATGRTVPSGPENFGVQQQQQPQQQPTPFNEYGLPVAAGAPVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWH3</accession>
    <name>A0A182PWH3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWH3"/>
    <dbReference type="STRING" id="199890.A0A182PWH3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011310-RA">
        <property type="protein sequence ID" value="AEPI011310-PA"/>
        <property type="gene ID" value="AEPI011310"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011310"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000175">
        <property type="entry name" value="Beta-1,4-mannosyltransferase bre-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779:SF1">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="185"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011310-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="458" mass="51980" checksum="C0EC8661E2D6421F" modified="2016-09-07" version="1">MLNSTSKHVLHCALLFGLLIVFEIFCGGIKVKESAFVVIDPWEEYGTLLTIVLYLLRLLTFLTLPQVLFNFFGLVIYNAFPEKVVLKGSPLLAPFICIRIVTRGDYSELVKTNVLRNMNTCLDTGLENFLIEVVTDKPIGLPKHRRTREIVVPKEYKTKTGAMFKARALQYCLEDTVNVLNNNDWVVHLDEETLLTENSVRGIINFVLDGKHPFGQGLITYANENVVNWLTTLADSFRVSDDMGKLRLQFKMFHKPYFSWKGSYVVTQVHAEKAVSFDNGIDGSVAEDCFFAMRAFSQGYTFNFIEGEMYEKSPFTLTDFLQQRKRWLQGILLVVRSTEIPLRNKILLGISLCSWITMPLSTSNMIFAAVYPIPCPNLIDFVCAFIAGFNIYMYVFGVIKSFSLYRFGLVKFLACVLGALCTIPINVVIENVAVIWGLVGKKNKFYVVQKDVRALVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX22</accession>
    <name>A0A182PX22_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX22"/>
    <dbReference type="STRING" id="199890.A0A182PX22"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011509-RA">
        <property type="protein sequence ID" value="AEPI011509-PA"/>
        <property type="gene ID" value="AEPI011509"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011509"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011509-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="476" mass="52716" checksum="E595A52676666B9B" modified="2016-09-07" version="1">MTNKEEAIMRQLTALEGAVQGLLSEARSGKVDPAMASIKLDLLQSLWNDGNKALLDLEESQGPQPRRATFMEAYAQTKLELKTPGPNRSDHLPRIELPRFNGDPTEWPAFAGRFEKRVAGLTGDAERYAFLVKCFERCDVARNSCEAFENSGMPFSKAWTGESGIKPTVVEDGLLVQLVLGKLDDDTITRVTRRLDAQTIPTWKELREELDRLSSQIYYEPRRREAPRYDRAQSTSKPARQPRMALSATTGTSPHSKDTRPSYKGVSILHGQEVTRRCYACDKLGHVGTLCPELRARSAFERLNLIMGKGKCVNCFSSQHPTAQCPSVKRCQPRAPFLLRAAIASRPSCLPSASFLRRAPFLLRAAIASRPSASFLLRVAVASRPSCLPSASFPRRTPFILHATFQPRVAVASSPSCLPSASFLLRTAWSTFHASLLLPAAWSPFHATFLLGASSPLRATMVAACFLTTWLRKEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYZ8</accession>
    <name>A0A182PYZ8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein TsetseEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PYZ8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015066-RA">
        <property type="protein sequence ID" value="AEPI015066-PA"/>
        <property type="gene ID" value="AEPI015066"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015066"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131927" description="Protein TsetseEP domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015066-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="28141" checksum="930563597F75DC4C" modified="2016-09-07" version="1">MLNKWLCVLCAVVVVLLTGSPVDGFLSEYQDELASVSVEAMREITVSWNANSVLNGLYNGRILSQIGDATVQMRIRDEYVAELLGNERDRLSESCAEFLEEYYAFYRTMWGVDLRNCMREAYQDLEYDRLDRFRPQASSVQRIMKTATYQTVRTLSMSDIFDQESIRDKLTDELQSYRSTWESYETTLQEELERHDDTVTGTMRRMNLCIDRALVYQQVDVEVIEEEIETNCDDRARKTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ59</accession>
    <name>A0A182PZ59_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Microsomal glutathione S-transferase 1</fullName>
            <ecNumber evidence="5">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:16438"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotrimer; The trimer binds only one molecule of glutathione.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAPEG family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PZ59"/>
    <dbReference type="STRING" id="199890.A0A182PZ59"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015124-RA">
        <property type="protein sequence ID" value="AEPI015124-PA"/>
        <property type="gene ID" value="AEPI015124"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015124"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000002">
        <property type="entry name" value="Microsomal glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040162">
        <property type="entry name" value="MGST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689:SF6">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015124-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="152" mass="17450" checksum="33E35CBD928F1E2A" modified="2017-10-25" version="2">MTNVFDTINDAALRSYVFWCSVLVAKMLLMSPLTSFNRIRKMAFASPEDTRMISKKLVPKYDDPDVERVRRAHQNDLENILPFFVIGFLYLLTNPAPWLAINLYRVVAASRILHTIVYAVIVIPQPARFLAFMGAMVPTAYMTLQTILYFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PKZ1</accession>
    <name>A0A240PKZ1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A240PKZ1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015271-RA">
        <property type="protein sequence ID" value="AEPI015271-PA"/>
        <property type="gene ID" value="AEPI015271"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015271"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF6">
        <property type="entry name" value="CHK DOMAIN OV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="140"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="568"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015271-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="859" mass="98243" checksum="938A1BA4C5800250" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PPQ8</accession>
    <name>A0A240PPQ8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PPQ8"/>
    <dbReference type="STRING" id="199890.A0A240PPQ8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015294-RA">
        <property type="protein sequence ID" value="AEPI015294-PA"/>
        <property type="gene ID" value="AEPI015294"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015294"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF372">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP76A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013009305" description="Serpin domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="37"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015294-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="405" mass="46369" checksum="72431ADCAF8C7795" modified="2017-10-25" version="1">MWYGMAVLCLWLQVESSSGVRGMTQLRFPYSSTNFSLSLYKAAFKSEQNVVVAPFTLHNSIAMLYSIATGTTRDRLREVFGLPANFTEFIINQKLLHYTLSDAGGSEGFHMKNRIVVNGFREVDARMRDIMHEDLDTVLMYFDFTQREGVVRRVNHFLSMRTNGLIRDTLFLGDVPKHLQLIQLSAGSFRPPFASSFDARDTIARDFRTGWIDKLYQTTTMFKEGDFRFARIPELEIEVLELPFHSRSDSVLWIMLPDRDAELDRIVKALEPEHFDAIQAHFSMKRAGIVVPVFSIKTEFNATDFLRDTIGLDALFRLRELRFFDDHDSALDGVLHRAAISVHERSAEAGGVATVHSFSKRSAPPSQATYQFYVGRSFLFALVKRSSKQLLFIGHLYRPHDLVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZE2</accession>
    <name>A0A182NZE2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZE2"/>
    <dbReference type="STRING" id="199890.A0A182NZE2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000022-RA">
        <property type="protein sequence ID" value="AEPI000022-PA"/>
        <property type="gene ID" value="AEPI000022"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000022"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051378">
        <property type="term" value="F:serotonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007210">
        <property type="term" value="P:serotonin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000367">
        <property type="entry name" value="Serotonin receptor 5-HT2 subtype"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF228">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTOR 2A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000022-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="230" mass="25569" checksum="562E5B2BDAC2B30B" modified="2016-09-07" version="1">MSSIKGSVSHPHLGYSNGGNRTMAGKRSRTVCDQGTQTPDSIERETRRQKFCSFRIHLNSVPTPAINFNLKFLGSKKRTNLSANAVATEQKATKVLGLVFFTFVFCWAPFFILNIIFAAWPEAKVPERIVSICLWLGYVSSTINPIIYTIFNKTFRAAFIRLLRCRCERSGRPPRYRSVTDSRGAISLCTPSALPLAISLQGSSLLTPSTTQATPLSDFRGSYEITDDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZI9</accession>
    <name>A0A182NZI9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZI9"/>
    <dbReference type="STRING" id="199890.A0A182NZI9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000070-RA">
        <property type="protein sequence ID" value="AEPI000070-PA"/>
        <property type="gene ID" value="AEPI000070"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000070"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000795">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="47"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="318"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000070-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="372" mass="41968" checksum="28C8DD25B0D6B058" modified="2016-09-07" version="1">SLSFKAFATCEIASALLTQFFVVKRLESSANMTLSCRFYKQKYPEVEDVVMVNVRSIAEMGAYVYLLEYNNIEGMILLSELSRRRIRSINKLIRVGKTEPVVVIRVDKNKGYIDLSKRRVSPEDVEKCTERFSKAKAVNSILRHVADIMDFDNQKLEELYEKTAWYFEEKHNYKVTAFDVFKQCAVDPSLLDECGLEPEVKESLLSNIQRKLVSQAVKIRADIECACYGYEGIDAVKTALRAGLALSTEELPIRINLIAPPLYVMTTSTPEKADGLKALESAIEVIKETIEKLGGVFKVQMAPKVVTATDEADLARKMERAEAENAEVSGDEEDDNEVGIKYKMDDDGDNKDDKDVEFEGSGDEDDDNKQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZJ7</accession>
    <name>A0A182NZJ7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZJ7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000078-RA">
        <property type="protein sequence ID" value="AEPI000078-PA"/>
        <property type="gene ID" value="AEPI000078"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000078"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000078-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="64494" checksum="F6BC7FCE34307920" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZV7</accession>
    <name>A0A182NZV7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZV7"/>
    <dbReference type="STRING" id="199890.A0A182NZV7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000188-RA">
        <property type="protein sequence ID" value="AEPI000188-PA"/>
        <property type="gene ID" value="AEPI000188"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000188"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF225">
        <property type="entry name" value="MALTASE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="4">
        <location>
            <begin position="198"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000188-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="703" mass="76837" checksum="5D825E91F2312415" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0D8</accession>
    <name>A0A182P0D8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0D8"/>
    <dbReference type="STRING" id="199890.A0A182P0D8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000370-RA">
        <property type="protein sequence ID" value="AEPI000370-PA"/>
        <property type="gene ID" value="AEPI000370"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000370"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF14">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
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    </dbReference>
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        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="471"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000370-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="610" mass="70892" checksum="BDEAA5B2589CC473" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P174</accession>
    <name>A0A182P174_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P174"/>
    <dbReference type="STRING" id="199890.A0A182P174"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000656-RA">
        <property type="protein sequence ID" value="AEPI000656-PA"/>
        <property type="gene ID" value="AEPI000656"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000656"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000656-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="112" mass="12306" checksum="FFA61917A1672963" modified="2016-09-07" version="1">MPPKKLAEPEVKPLIGRIGTNLRIGIVGVPNVGKSTFFNVLTKSAAPAENFPFCTIDPNESRYWLMIVFPARSFAYQTERRAMGKPGRAGTGQSQLSCVARVLNRSAFRVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1G3</accession>
    <name>A0A182P1G3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1G3"/>
    <dbReference type="STRING" id="199890.A0A182P1G3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000745-RA">
        <property type="protein sequence ID" value="AEPI000745-PA"/>
        <property type="gene ID" value="AEPI000745"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000745"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="47"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000745-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="324" mass="36690" checksum="133FEB5A8AB7FE55" modified="2016-09-07" version="1">MLLALFNFYFTVGFYAIGVFIATCIFKLLFYAAYLQDLNSTPLDSRYDYIIVGSGTAGSWIASRIPSHKVLLLEAGPGRSALMDVPLFLPLLQGTQYDWQYVTEPQAGACWAMNENRSRWPMGKTVGGTHMLNNMIHFKAERKDFTEWFAKAQDLNRFMEFFERDKWSTVERGYTTELGRVILDSAKRLGFGEKDFFQPMVTTLNGRRWTTAHEYESSKRLAHETMTNTVGYVSLGSNYSSDLQFMVLPAGLSSDGGVHLRKIVNIKDSVWKEYYEPLLKVGQQAVTVLPILLHPKSVGEIGLKSANVHDAPFINPNYLSSKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1Z2</accession>
    <name>A0A182P1Z2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1Z2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000926-RA">
        <property type="protein sequence ID" value="AEPI000926-PA"/>
        <property type="gene ID" value="AEPI000926"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000926"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000926-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="19023" checksum="403E154712119DFE" modified="2016-09-07" version="1">MESKFVLYIKFNGCIIVLLVGYYVTLSAHRWLTQTHSWNEYPFVVGLELRNHPIVDGLFQIMWITAVASLYQALWLEVELLLYPIGFMVGLEMFIIGAGDVIKRWNDEAEDCFLRRGQDAVVCFAILVYFYYTLYILKKLFRSKDRKTCVSQVATVHPLVRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P238</accession>
    <name>A0A182P238_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P238"/>
    <dbReference type="STRING" id="199890.A0A182P238"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000972-RA">
        <property type="protein sequence ID" value="AEPI000972-PA"/>
        <property type="gene ID" value="AEPI000972"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000972"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17387">
        <property type="entry name" value="MFS_MFSD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF1">
        <property type="entry name" value="GH21943P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="634"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000972-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="775" mass="82273" checksum="8C16EE035B4E7648" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P285</accession>
    <name>A0A182P285_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P285"/>
    <dbReference type="STRING" id="199890.A0A182P285"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001019-RA">
        <property type="protein sequence ID" value="AEPI001019-PA"/>
        <property type="gene ID" value="AEPI001019"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001019"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00916">
        <property type="entry name" value="Npc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033916">
        <property type="entry name" value="ML_Npc2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF36">
        <property type="entry name" value="NIEMANN-PICK TYPE C-2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130862" description="MD-2-related lipid-recognition domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="7">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001019-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="244" mass="25679" checksum="052FEE0FD4CD879A" modified="2016-09-07" version="1">MFRALFLIALVPALVYGNVSRACTNGRPQPTNVIIEGCTAPPCDLVRGQDVVAFIDFTTDRAVTSMTTVATATALGVTTNYPLGPNAVTCNFLQGSSCPLSANEDVTYRLTMPILAIYPLVSLSIEIDIVGQDNISVACFVVDAQVVTATKLDRAVTSMTTVATATALGVTTNYPLGPNAVTCNFLQGSSCPLSANEDVTYRLTMPILAIYPLVSLSIEIDIVGQDNISVACFVVDAQVVTATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2T4</accession>
    <name>A0A182P2T4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL_TRIO_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2T4"/>
    <dbReference type="STRING" id="199890.A0A182P2T4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001220-RA">
        <property type="protein sequence ID" value="AEPI001220-PA"/>
        <property type="gene ID" value="AEPI001220"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001220"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF38">
        <property type="entry name" value="HL01515P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL/TRIO N-terminal" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001220-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="146" mass="16953" checksum="8BE0D4CD1EED7B68" modified="2016-09-07" version="1">MASLKFDDNNVPYLDLGDGYRIALEGDEYTDAKSKEKAARELRETPDVVEQSLQELRALLEGEQTLYVPMDNDPFMIKFLRPCKYYAQSAFELIKRYYRFRSKHPDLCDELYPASVKHVYAEGLVHFLPLRDQHGSRILVLECGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2Z2</accession>
    <name>A0A182P2Z2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="STRING" id="199890.A0A182P2Z2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001279-RA">
        <property type="protein sequence ID" value="AEPI001279-PA"/>
        <property type="gene ID" value="AEPI001279"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001279"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
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    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
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            <end position="193"/>
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    </feature>
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            <end position="221"/>
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        <location>
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    </feature>
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        <location>
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            <end position="276"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001279-PA"/>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="664" mass="73594" checksum="3867D564FD63F94D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3N7</accession>
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            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
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    <dbReference type="STRING" id="199890.A0A182P3N7"/>
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        <property type="gene ID" value="AEPI001522"/>
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    <dbReference type="Proteomes" id="UP000075885">
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        <property type="entry name" value="Pkinase_C"/>
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        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
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        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="32"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00433"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001522-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="75" mass="8696" checksum="6F64A017FF7EA50C" modified="2016-09-07" version="1">MSLPVLVPLDHRLIDVQPVRHEPSSIETRSAEDVSNFDEEFTSEKPALTPPKDPRVLTEVEQTYFKDFTYMADWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P417</accession>
    <name>A0A182P417_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="199890.A0A182P417"/>
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        <property type="protein sequence ID" value="AEPI001653-PA"/>
        <property type="gene ID" value="AEPI001653"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001653"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="937"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
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            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="736"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001653-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1084" mass="120039" checksum="8EC98AA16AE69A89" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P461</accession>
    <name>A0A182P461_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Dynein beta chain, ciliary</fullName>
        </recommendedName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P461"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001697-RA">
        <property type="protein sequence ID" value="AEPI001697-PA"/>
        <property type="gene ID" value="AEPI001697"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001697"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000667">
        <property type="entry name" value="Dynein axonemal heavy chain 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000219">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000002">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000411">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000001">
        <property type="entry name" value="Dynein, axonemal, heavy chain 9"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="17">
        <location>
            <begin position="200"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="18">
        <location>
            <begin position="1371"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="19">
        <location>
            <begin position="1907"/>
            <end position="2233"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="23">
        <location>
            <begin position="2390"/>
            <end position="2508"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="24">
        <location>
            <begin position="2726"/>
            <end position="2821"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="21">
        <location>
            <begin position="2869"/>
            <end position="3129"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="20">
        <location>
            <begin position="3143"/>
            <end position="3483"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="22">
        <location>
            <begin position="3512"/>
            <end position="3729"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="16">
        <location>
            <begin position="3970"/>
            <end position="4090"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="25">
        <location>
            <begin position="4122"/>
            <end position="4258"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="26">
        <location>
            <begin position="4267"/>
            <end position="4559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="895"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3158"/>
            <end position="3205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3357"/>
            <end position="3398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="911"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001697-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="29">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4561" mass="524244" checksum="BF062E49222A3EF7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P474</accession>
    <name>A0A182P474_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shavenoid isoform B-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P474"/>
    <dbReference type="STRING" id="199890.A0A182P474"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001710-RA">
        <property type="protein sequence ID" value="AEPI001710-PA"/>
        <property type="gene ID" value="AEPI001710"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001710"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035317">
        <property type="term" value="P:imaginal disc-derived wing hair organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057507">
        <property type="entry name" value="Sha_B-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39387">
        <property type="entry name" value="SHAVENOID, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39387:SF1">
        <property type="entry name" value="SHAVENOID, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23328">
        <property type="entry name" value="Sha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shavenoid isoform B-like N-terminal" evidence="2">
        <location>
            <begin position="132"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001710-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="226" mass="24373" checksum="D9F0235422FAA183" modified="2016-09-07" version="1">MITGKSANHGTTCTAGSERLLTMARQRVLAPERHAEGSTSHRPVRDGRHPGRWSLLGRDNYTALPTRTTRTGRPHGRWALMLLLLPSLTFCTLIGRSSAAATPLKSPLPGYGRGAPMYKGRMGGLTESGRISNLTRLHSGDLFYTFESEKCDTDTCVGLSSGTAELSIGGDRTGTGTGPQRIPGSTDHNIKEIDMSSDAGIECKCQCLPHLSTYREDLGICVDDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4C1</accession>
    <name>A0A182P4C1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="31">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A182P4C1"/>
    <dbReference type="STRING" id="199890.A0A182P4C1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001757-RA">
        <property type="protein sequence ID" value="AEPI001757-PA"/>
        <property type="gene ID" value="AEPI001757"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001757"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="40"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="155"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="262"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001757-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="416" mass="45411" checksum="EE0F3F27A94032C9" modified="2016-09-07" version="1">MLQNVLRQVVRSVGSIGTRSFASSSFGTASGPTSPLTYLSEDELVMKETVAKLAQEQIAPLVKKMDEEHQFDPSVVRALFDNGLMGIEVSDEYGGSACNFMTTMLVVEELSKVCPATAAFVDIHNTLVNSLMIKLGTAEQKSKYLPKLSQEYSGSFALSEPSAGSDAFSLKTTAKKDGNHYILNGTKMWISNSDLSGVFLIMANANPSAGYRGITTFIVEREYEGFTVGKKESKLGICASGTCTLHLDNVRVPEENILGEFGKGYQYAAGFLNEGRIGIGAQMIGLAQGCLDATIPYLLERKQFGSDLYSFQSMQHQIATIATEIEAARLLTYNAARLQEAGAPFLKQAAMAKFYASEVAQRTTVKCIDWMGGVGFTKDFPQEKYYRDCKIGAIYEGTTNMQLSTIAKVMKKEYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4V5</accession>
    <name>A0A182P4V5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4V5"/>
    <dbReference type="STRING" id="199890.A0A182P4V5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001942-RA">
        <property type="protein sequence ID" value="AEPI001942-PA"/>
        <property type="gene ID" value="AEPI001942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001942"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050260">
        <property type="entry name" value="FAD-bd_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429:SF2">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="256"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001942-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="481" mass="53141" checksum="AD2E717027FD5C62" modified="2016-09-07" version="1">MAENLSYTYVIVGGGIAGVTCAETLALLRPHDSSDRILLLTESTLVKAVTNVVPLGKILNRFDVKEKSGQELAAASNIDVLLDQLDTIVSEDRLLRTTAGRCINYRYLCLCTGARPNIIDKAKGNANVIGIRDTESVEEFRKRIHTATRLVVVGNGGIASELVYEVEGMEEIHWVIKDPYISSTFVDSGAATFFKERLNEKGSTEKEKTIYKRMRYTEQNDGSSPSVAGSKRGAALGPDWHRAFDIRKHGEVTTKNANKVTVHHSVEVEGIKEVSSGLQVHLTDGKTIECDFVVSATGVVPAISWAGGCDRPFKLGPDGGLFVNWSMETSVDGIYAAGDVCYAGWEHAPHWFQMRLWTQARQMGAMAARSMAAKRAGEEIYQDFCFEMFNHVTTLFGYQVVLLGRYNGQGLNDKYEVLLRMTPGLEYIKFVLVDGRLQGALLVGETGLEETCENLILNQLDLSPYGEDLLNPDIDIEDYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6H0</accession>
    <name>A0A182P6H0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6H0"/>
    <dbReference type="STRING" id="199890.A0A182P6H0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002518-RA">
        <property type="protein sequence ID" value="AEPI002518-PA"/>
        <property type="gene ID" value="AEPI002518"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002518"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000023">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000037">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
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        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
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        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="3">
        <location>
            <begin position="73"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002518-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="352" mass="39456" checksum="48F31CEE2CF51A88" modified="2016-09-07" version="1">MIFFVPLSVTLHCIRPPPPHCPHILLSAATGCACTGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSDWVRIIFLYWLPCILRMSRPGRDLSMEYPPTPTSDSSERKAHIQDVELKERSSKSLLANVLDIDDDFRHNCRPLTPGGTLPHNPTYFRTVYSSDDGSIGPIGTNRMPDAIAPPHTCFTSSADYELALILKEIRFITDQIRKEDEESDIAKDWKFAAMVVDRLCLIIFTFFTIVATIAVLFSAPHIIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6H1</accession>
    <name>A0A182P6H1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">cGMP-dependent protein kinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6H1"/>
    <dbReference type="STRING" id="199890.A0A182P6H1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002519-RA">
        <property type="protein sequence ID" value="AEPI002519-PA"/>
        <property type="gene ID" value="AEPI002519"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002519"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12083">
        <property type="entry name" value="DD_cGKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000072">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000064">
        <property type="entry name" value="cGMP-dependent protein kinase, isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF147">
        <property type="entry name" value="CGMP-DEPENDENT SERINE_THREONIN PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00104">
        <property type="entry name" value="CGMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="8">
        <location>
            <begin position="695"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="8">
        <location>
            <begin position="813"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="953"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="575"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002519-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109913" checksum="CB2121BF9870045D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6K1</accession>
    <name>A0A182P6K1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6K1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002549-RA">
        <property type="protein sequence ID" value="AEPI002549-PA"/>
        <property type="gene ID" value="AEPI002549"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002549"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002549-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="60" mass="6635" checksum="9BEB059A281BC950" modified="2016-09-07" version="1">MSTSVEEVDEQVLEIETQSTTSTTSTVIDNSSVNNNGTTNNHSRAQKSYKNLHEFSAFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6K2</accession>
    <name>A0A182P6K2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6K2"/>
    <dbReference type="STRING" id="199890.A0A182P6K2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002550-RA">
        <property type="protein sequence ID" value="AEPI002550-PA"/>
        <property type="gene ID" value="AEPI002550"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002550"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF55">
        <property type="entry name" value="GEO08227P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130871" description="MD-2-related lipid-recognition domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="5">
        <location>
            <begin position="27"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002550-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="160" mass="17990" checksum="D0E6AFB120AA6B7D" modified="2016-09-07" version="1">MKCFQTVVSVAILTLCLHAAWAEVVHFKKCPGEEKCTIHEVSITPCPEAEEGRACTVYRGTNVSITFDFTPEFAANELTTDVAWTQPNFDLPFVGMDTAACKHTKCPAVSGTRQTYTYDLPIKKSYPPKHYDVKWKLTSENNDSCCFIVQINITKKTKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6N8</accession>
    <name>A0A182P6N8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6N8"/>
    <dbReference type="STRING" id="199890.A0A182P6N8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002586-RA">
        <property type="protein sequence ID" value="AEPI002586-PA"/>
        <property type="gene ID" value="AEPI002586"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002586"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002586-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1024" mass="118200" checksum="30FC0A2F630577AA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7F9</accession>
    <name>A0A182P7F9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhomboid-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7F9"/>
    <dbReference type="STRING" id="199890.A0A182P7F9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002861-RA">
        <property type="protein sequence ID" value="AEPI002861-PA"/>
        <property type="gene ID" value="AEPI002861"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002861"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002861-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="197" mass="21837" checksum="E1473E39F689A3E7" modified="2016-09-07" version="1">MQKQTTMADSRKPPPGKVVPVHRGKATTNANGSSTCQRAWIESDRQNRQPESEREPFLAGGGSGSEGSETSSLECEQLCTEVFKNKARIFAIDLERGRKRCEKGSTSTRIGSSDSANNDDSPSDTKLVDRALKVYQRKRQFCQSCPWTVPWSLLIVSALQSEERFNPNRDSQAPTADKSVQLLDALTSTKINESLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7Y4</accession>
    <name>A0A182P7Y4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7Y4"/>
    <dbReference type="STRING" id="199890.A0A182P7Y4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003037-RA">
        <property type="protein sequence ID" value="AEPI003037-PA"/>
        <property type="gene ID" value="AEPI003037"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003037"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003037-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="150" mass="17156" checksum="DE56B4EC871AB4E3" modified="2016-09-07" version="1">MEALSDGHTVAPIIKVAYLHARRGAKTYMFHFGYQSKESEYPQRLGSVRGEDLPYIFGLPLVQGGPVFPQNYSRQDMGVNEAVLNFVTNFCKTGDPNEAGHQQAPPLHPDYGTAKERTRFRLITWETYETTTQQYLSICEYRSAHENDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P920</accession>
    <name>A0A182P920_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P920"/>
    <dbReference type="STRING" id="199890.A0A182P920"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003424-RA">
        <property type="protein sequence ID" value="AEPI003424-PA"/>
        <property type="gene ID" value="AEPI003424"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003424"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000262">
        <property type="entry name" value="protocadherin-23 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131122" description="Cadherin domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="138"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="263"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="372"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003424-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="733" mass="80282" checksum="8D58F3631D4BD407" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P965</accession>
    <name>A0A182P965_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P965"/>
    <dbReference type="STRING" id="199890.A0A182P965"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003469-RA">
        <property type="protein sequence ID" value="AEPI003469-PA"/>
        <property type="gene ID" value="AEPI003469"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003469"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003469-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="252" mass="26645" checksum="DBBC98DD6EB0F97B" modified="2016-09-07" version="1">MNLAGKVVLITGASSGIGAATALKFSQLGASLALTGRKVDNLNEVAKQCTGSPFVVAGDISKEADTERVLKATIEKYGKLDVLVNNAGIIETGTIETTNLEQYDRVMNTNIRAVYHLTMLAVPHLLKSQGNVVNVSSVNGIRSFPGVLAYNISKMAVDQFTRCVALELAAKGVRVNCVNPGVTVTNLHKRGGMDEQTYAKFLEHSKNTHAMGRPGQASEVADAIVFLASDSASFITGASLPIDGGRHAMCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9B7</accession>
    <name>A0A182P9B7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large subunit GTPase 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9B7"/>
    <dbReference type="STRING" id="199890.A0A182P9B7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003521-RA">
        <property type="protein sequence ID" value="AEPI003521-PA"/>
        <property type="gene ID" value="AEPI003521"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003521"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000008">
        <property type="entry name" value="Large subunit GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="162"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003521-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="618" mass="70370" checksum="9449E002EA9A3436" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9T5</accession>
    <name>A0A182P9T5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P9T5"/>
    <dbReference type="STRING" id="199890.A0A182P9T5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003689-RA">
        <property type="protein sequence ID" value="AEPI003689-PA"/>
        <property type="gene ID" value="AEPI003689"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003689"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06731">
        <property type="entry name" value="PDZ1_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06732">
        <property type="entry name" value="PDZ2_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06733">
        <property type="entry name" value="PDZ3_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06734">
        <property type="entry name" value="PDZ4_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000005">
        <property type="entry name" value="Membrane associated guanylate kinase, WW and PDZ domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000001">
        <property type="entry name" value="Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000081">
        <property type="entry name" value="PDZ domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000232">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316:SF40">
        <property type="entry name" value="LD27118P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316">
        <property type="entry name" value="MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="296"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="486"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="854"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="916"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003689-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1254" mass="135452" checksum="42B436AFC5393E33" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9Y1</accession>
    <name>A0A182P9Y1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P9Y1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003735-RA">
        <property type="protein sequence ID" value="AEPI003735-PA"/>
        <property type="gene ID" value="AEPI003735"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003735"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001221">
        <property type="entry name" value="Axonemal dynein heavy chain 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000543">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000009">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000004">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000002">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000320">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1954"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2235"/>
            <end position="2416"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2562"/>
            <end position="2928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3187"/>
            <end position="3214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3407"/>
            <end position="3490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003735-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="4609" mass="531349" checksum="D0D40D2A134A1A85" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAC3</accession>
    <name>A0A182PAC3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182PAC3"/>
    <dbReference type="STRING" id="199890.A0A182PAC3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003877-RA">
        <property type="protein sequence ID" value="AEPI003877-PA"/>
        <property type="gene ID" value="AEPI003877"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003877"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="349"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="564"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="711"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="720"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="787"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003877-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="816" mass="86924" checksum="CF51BA63BBF58966" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAP5</accession>
    <name>A0A182PAP5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAP5"/>
    <dbReference type="STRING" id="199890.A0A182PAP5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004000-RA">
        <property type="protein sequence ID" value="AEPI004000-PA"/>
        <property type="gene ID" value="AEPI004000"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004000"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004000-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="112" mass="12770" checksum="C87639AA93AB202D" modified="2016-09-07" version="1">MMTSKVLVNKFSSSIRHVYVVNFVPSLSFSTNKPPSDKPVSPRMEEFQKKLREKTPIGKLDEVVGKHPYQEKEPLEPWPNNTNPNTGEIGGPKGPEPTRYGDWERKGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB68</accession>
    <name>A0A182PB68_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7802 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PB68"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004173-RA">
        <property type="protein sequence ID" value="AEPI004173-PA"/>
        <property type="gene ID" value="AEPI004173"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004173"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056704">
        <property type="entry name" value="DUF7802"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982">
        <property type="entry name" value="AGAP005361-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982:SF1">
        <property type="entry name" value="SPIROCYCLASE, AVEC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25085">
        <property type="entry name" value="DUF7802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7802" evidence="2">
        <location>
            <begin position="18"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004173-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="422" mass="48463" checksum="6093A85DAA31D74B" modified="2016-09-07" version="1">MEALSTVRTYEQFQKDFPNWLVNVRNPVELFNRQPSYVVSQAFCIVGALLCLAHAFHRGGRWPFLWFGSVLSGVLIEGSMYFSPHGETIWLSPTVIDLFHQRIPLFIFFVYPFFYYQAFWSVSKLQLKCRWSEHIAIGMLVVLFDLPFDMFSVKFLHWTLHETEPMLSERIYCAPWTLLLFFAATTFTFSYLFHNLRNWVEPAMAKKDRWTAGKMRTELIASIGAASVSLSVGSGLFLAFNYPLHTILGIPTRVVVIGVFLCVTAVFWKFDRKSNRQLPLRQSFLDHTLNGVIVGHFLLYLVLGFVLSPEEAVSSGRHQPIGDCSNVTTDTPLCLDTFSNSDFDFHCITKQPNVGAYWYTVCGTPHENRSEFVFAMAVITFIASLILWTIHYDFDVRFKIYDLVRKSASTPKGVNNKTLKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBF6</accession>
    <name>A0A182PBF6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Synapsin pre-ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synapsin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBF6"/>
    <dbReference type="STRING" id="199890.A0A182PBF6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004261-RA">
        <property type="protein sequence ID" value="AEPI004261-PA"/>
        <property type="gene ID" value="AEPI004261"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004261"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000008">
        <property type="entry name" value="Synapsin III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001359">
        <property type="entry name" value="Synapsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020898">
        <property type="entry name" value="Synapsin_ATP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019736">
        <property type="entry name" value="Synapsin_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020897">
        <property type="entry name" value="Synapsin_pre-ATP-grasp_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10841">
        <property type="entry name" value="SYNAPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10841:SF17">
        <property type="entry name" value="SYNAPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02078">
        <property type="entry name" value="Synapsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02750">
        <property type="entry name" value="Synapsin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10581">
        <property type="entry name" value="Synapsin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01368">
        <property type="entry name" value="SYNAPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Synapsin pre-ATP-grasp" evidence="6">
        <location>
            <begin position="159"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Synapsin ATP-binding" evidence="7">
        <location>
            <begin position="259"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004261-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33191" checksum="F2B663DE11A8747E" modified="2016-09-07" version="1">MNDPQAGTLSFASFKSSFTSNVNFLKRRFSSGDLSSECEDVDPKDLPPAARPQPPLQQQPMPGGPPNIPPPPAPGTAGSVSPGGPVPPGSAPPTGGPELSLSFGKGPTQRGTSAPSSPAKSRESLLQRVQSLTGAARDQGASIIGAAVSTASRVQPFNRDKCFTLLVVDDQNTDWSKYFRGKRLHSDYDIRVEQAEFREIMLTASADSGPMVGCNRGGSKQVKPFRPDFILVRQPPRDGSKDYRSTLLGLKYGGVPSINSLHSLYQFQDKPWVFAHLLQLQRRLGRDAFPLVEQTFFPNPKDMVSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBM0</accession>
    <name>A0A182PBM0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBM0"/>
    <dbReference type="STRING" id="199890.A0A182PBM0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004325-RA">
        <property type="protein sequence ID" value="AEPI004325-PA"/>
        <property type="gene ID" value="AEPI004325"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004325"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10529">
        <property type="entry name" value="SET_SETD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="150"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004325-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="339" mass="36275" checksum="C66E1A9DD5E5C98D" modified="2016-09-07" version="1">MTTMAMNSSSMAGGLLPTAPMSASSSVGMYCDSSNSSVGVTKKLSKKAEAALNSRMNGGKRVVAGKELRSVTSGASAAAASRPSKKKSKSAEQSTEKLMNMIRTFIDSYERATTNHYSPELRARLQAFAKLQAHNPLLTDSRLLTVPSGANLIPRCTTVPHAGGKILIGTSDIEPRAPIIEVRGKYMLTNQHKQLQSLFNMAANGKLSQNKNAGPFLFLYQLPAAGCGGMELCVDTRTYGNDARFVRRSCRPNAELLHSVEKGVVHLYIVATTNIKSNTEITIRHDEQLIHRMGGVVILTHTTVTNVCACGLIKDCAYSAQLNESAGIPNVSSSVASVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCP6</accession>
    <name>A0A182PCP6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCP6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004701-RA">
        <property type="protein sequence ID" value="AEPI004701-PA"/>
        <property type="gene ID" value="AEPI004701"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004701"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832:SF2">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832">
        <property type="entry name" value="SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="239"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004701-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="367" mass="40540" checksum="5BBE00CDCAF6A588" modified="2016-09-07" version="1">MQEVEYFNDNITTATAESMERKHPRKCSYDLLDRPEVLPVLQTPQPPRHRAAYNKCDENVNYTADPLLLTSSDEDSSGSPTGEMNNCIKFMEKPALIKRFALGFLRSTEESLPLMCHKSSPTSPQKKLNDILSEDIYTLDAIVSSKFGDSCKQSFAGSTRLLPASGNAGPTATSAATVATATTVADGVEYEFKRNLIRQTNSASSSPKRYPTVTPPKHADSLNSVSLGEDSDELDRASWFQAGLPRELSLEVLTQQSPGAFLVRRSTTKHGCFALSLRVPPGPGPKVVHYLIMKTERGYKIKGFTKEFSSLRALITHHSVMPEMLPVPLSLPRPQNIPTKCKHTDDYDTFSALNEFSKLFSDLDICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDN9</accession>
    <name>A0A182PDN9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDN9"/>
    <dbReference type="STRING" id="199890.A0A182PDN9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005044-RA">
        <property type="protein sequence ID" value="AEPI005044-PA"/>
        <property type="gene ID" value="AEPI005044"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005044"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF399">
        <property type="entry name" value="CHITINASE 6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131168" description="GH18 domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="44"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005044-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="432" mass="48388" checksum="77A0A4FC0E4AD7BD" modified="2016-09-07" version="1">MSASWRTAFCAASCLATVVLVLCGVVVVQVHSFPCETQGSVQLPMIVCFITASNEHYDYDSLRTGLCSHIVLIDLIGVGKDGELELLQTSSRSLHRFSKLRQHFSDVGDEAKFIISIGGVAQKSSHFSKALKTPESRYALSDELISFVIKHKLGGIDIAWFYPAQFGGAESDRTNLIVFLRDLYLRTNACGLTLSLTVGVDPKDIEVSYDVPRINEVVDFVNLLTGDYHNPTTPTHISPLYGQGPRDRLNINYSVMSYIEAGLNPRKIVIMGSCYAYLYISKIEKNDTCTTTKLRTVMRLSYLSATELVTRESFRTSWDDMRHVPYGTLTKGITKKWLTYNDVDSMRRKADYAQHLQLGGMGLFSVDEDDYGGRTGVGRYPMLRAIVSILYPELDCSEEDPEEEIETIVCPYTGYLTDPVEPECYYTCEEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE11</accession>
    <name>A0A182PE11_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PE11"/>
    <dbReference type="STRING" id="199890.A0A182PE11"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005166-RA">
        <property type="protein sequence ID" value="AEPI005166-PA"/>
        <property type="gene ID" value="AEPI005166"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005166"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="144"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="375"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="639"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005166-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="793" mass="92599" checksum="C1AAD1C675C339D6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEA8</accession>
    <name>A0A182PEA8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL or FBLL1 assemble stepwise onto the snoRNA. Interacts with NOLC1/Nopp140. Interacts with NOPCHAP1, NUFIP1, RUVBL1 and RUVBL2; NOPCHAP1 bridges the association of NOP58 with RUVBL1:RUVBL2 and NUFIP1. Interacts with PIH1D1. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEA8"/>
    <dbReference type="STRING" id="199890.A0A182PEA8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005263-RA">
        <property type="protein sequence ID" value="AEPI005263-PA"/>
        <property type="gene ID" value="AEPI005263"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005263"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000004">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="303"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="452"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005263-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="561" mass="61796" checksum="FBF7CBADAF325FBB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEE2</accession>
    <name>A0A182PEE2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PEE2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005297-RA">
        <property type="protein sequence ID" value="AEPI005297-PA"/>
        <property type="gene ID" value="AEPI005297"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005297"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="4">
        <location>
            <begin position="1086"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005297-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1297" mass="146256" checksum="54339DD36F3173A6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEY4</accession>
    <name>A0A182PEY4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAC-A/B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEY4"/>
    <dbReference type="STRING" id="199890.A0A182PEY4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005489-RA">
        <property type="protein sequence ID" value="AEPI005489-PA"/>
        <property type="gene ID" value="AEPI005489"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005489"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="66"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005489-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="213" mass="22800" checksum="763ABFD98EAB0F29" modified="2016-09-07" version="1">MPELTEITESAAVASSATGTTEAKLEDAPSDTETEDSIPELEDAGAAATTQLSAGEIPDISKAKQSRGEKKARKIMSKLGLKPVQGVNRVTIRKSKNILFVINNPDVYKNPHSDTYIIFGEAKIEDLTQQAQVAAAEKFKAPEATPAAGEASSSTNVVTPIAEEDEEEVDDTGIDDKDIDLVMSQANVKRAKAIRALKNNDNDIVNAIMELTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF02</accession>
    <name>A0A182PF02_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PF02"/>
    <dbReference type="STRING" id="199890.A0A182PF02"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005507-RA">
        <property type="protein sequence ID" value="AEPI005507-PA"/>
        <property type="gene ID" value="AEPI005507"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005507"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08310">
        <property type="entry name" value="Death_NFkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01177">
        <property type="entry name" value="IPT_NFkappaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07884">
        <property type="entry name" value="RHD-n_Relish"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028320">
        <property type="entry name" value="iASPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033926">
        <property type="entry name" value="IPT_NFkappaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000451">
        <property type="entry name" value="NFkB/Dor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24164">
        <property type="entry name" value="RELA-ASSOCIATED INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24164:SF4">
        <property type="entry name" value="RELA-ASSOCIATED INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00057">
        <property type="entry name" value="NFKBTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHD" evidence="10">
        <location>
            <begin position="185"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="786"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="819"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="856"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="525"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="958"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1032"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="958"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="972"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1032"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005507-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1148" mass="126843" checksum="84AD7FD0DC8F2A2B" modified="2019-01-16" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF46</accession>
    <name>A0A182PF46_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TALE/TGIF homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PF46"/>
    <dbReference type="STRING" id="199890.A0A182PF46"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005551-RA">
        <property type="protein sequence ID" value="AEPI005551-PA"/>
        <property type="gene ID" value="AEPI005551"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005551"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000059">
        <property type="entry name" value="TGFB-induced factor homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="93"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="95"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005551-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="486" mass="53958" checksum="7282DB266AA07300" modified="2016-09-07" version="1">MHHEEFEITMVPMESTTVLTTSGAGNLKRDVRDMVREANFQTKLLMQENEAQDYHFQHASSADDTEGSDQEHTMGDMTFKTDPDETMNSSSQSSSRKRRGNLPKQSVKILKRWLYEHRFNAYPSDAEKLTLSQEANLTVLQVCNWFINARRRILPEMIRRDGHDPIHYTISRRGKKLGGSFGQDGINPLMMNLASEVVIGATEEIIEEEEVIEDGVPQIITSHGQQYVQTPTGLVKVEEDVDFEDHIIYRSDDSNIEYEYAQSEEEIPVNEQGEWDGMIRYANDKNDEDEIPEEITEEEVIASDGAENEYFTTTSHTNLANVPLQQTTTNVTGGIQRVIISQSNTGTGTVTNTAQGSTTLGTLKLGGNLTAVPLQSGVKVGSKKLTVVTSSGKMATVNATPLGESNTKTITLVQSGNNAGNANNNNNNTNNNNSQNTNPHTTTAVKVKGVIRDDKDQFKCLYLLVETAVAVRQREKEQDDVHVLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFF7</accession>
    <name>A0A182PFF7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PFF7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005664-RA">
        <property type="protein sequence ID" value="AEPI005664-PA"/>
        <property type="gene ID" value="AEPI005664"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005664"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17088">
        <property type="entry name" value="FERM_F1_FRMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000027">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221:SF3">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="3"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="757"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005664-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1459" mass="157649" checksum="D5DFC4F6F2F66A79" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFI6</accession>
    <name>A0A182PFI6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="7 15">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="7 15"/>
    <dbReference type="AlphaFoldDB" id="A0A182PFI6"/>
    <dbReference type="STRING" id="199890.A0A182PFI6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005693-RA">
        <property type="protein sequence ID" value="AEPI005693-PA"/>
        <property type="gene ID" value="AEPI005693"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005693"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="16">
        <location>
            <begin position="7"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005693-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="239" mass="27179" checksum="D714F401D0D98320" modified="2016-09-07" version="1">MAGDKYSILLPTYNERENLPIIIWLIVKYMQEAKINYEVIVIDDGSPDGTLEVAKQLQKIYGEERILLRPRAAKLGLGTAYIHGIEHATGDYIIIMDADLSHHPKFIPQFVELQKKGDFDIVSGTRYKGTGGVYGWDFKRKLISRGANFLSQLLLRPNASDLTGSFRLYRKEVLKELISRCTSKGYVFQMEMIVRARQLNYTIGEVPISFVDRVYGQSKLGGSEIIQFAKNLLYLFATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PG83</accession>
    <name>A0A182PG83_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PG83"/>
    <dbReference type="STRING" id="199890.A0A182PG83"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005942-RA">
        <property type="protein sequence ID" value="AEPI005942-PA"/>
        <property type="gene ID" value="AEPI005942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005942"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039147">
        <property type="entry name" value="ASB17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20966">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20966:SF2">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SOCS box" evidence="3">
        <location>
            <begin position="296"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005942-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="338" mass="38469" checksum="CB888DEA3EF89C1E" modified="2016-09-07" version="1">MEYVFDVFFEECFKTMERSGLASRAGRRDIISHLNSVISGCIQGRQTATTQLAVGLAVTSAIDYHNRMKGDNYEVCMMGKYHNVLYIALRITWDWGLEDSTIVRNLLDEIFKCEKTFERLFLGALFGCNAPHFIAGWKSDFNDQDENLRAVVFFLHHSAKARAIYPTYSYAYQCLRQTKFIDVPIDSCGKASPLRVALQASAPDIVLILLRHGANPCPDDGGASPVLSLLEKLAECENRCYPFQLVSCLKLLLRTIVMVEMPYKPHLYEVRKEMFHCKYAALLEDGLLPPEQVYGVPTLKHSCRCLIRDVLRDNFQLPGSVVKLPLPRKLQKYIDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGC0</accession>
    <name>A0A182PGC0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGC0"/>
    <dbReference type="STRING" id="199890.A0A182PGC0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005979-RA">
        <property type="protein sequence ID" value="AEPI005979-PA"/>
        <property type="gene ID" value="AEPI005979"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005979"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF216">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="112"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005979-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="335" mass="37996" checksum="F96DE104C6F9A883" modified="2016-09-07" version="1">MSVKVDAVTSEVFSVAPTADKKMAPVRTIPECLKRKAADELNEQESKIAEELTMLKTWMNQSGHIRGRMEDQFLLGFLRSCKHSMERVKEKLDTYYTIRSVLPEVMRTRDPLDPFVRSVIKMGVTVPLPKTVNPDDPKIILIRGDAFDGDVCDFPDILKVFTMIGDILLRDDDQMMICGQAAIIDLGHSSSSHLFNFNLSFLRKASILNQQASPLRQKGFHFINTPKSFDLVLNIFKGLMTEKNRKRTIVSHGSSLESLHKYFPPAVLPAELGGELGPVQQYVDEWEQKLIDNRAYLIEEESLGVDETKRRTTNPLAEEKDLFGTAGTFRKLEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH38</accession>
    <name>A0A182PH38_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PH38"/>
    <dbReference type="STRING" id="199890.A0A182PH38"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006247-RA">
        <property type="protein sequence ID" value="AEPI006247-PA"/>
        <property type="gene ID" value="AEPI006247"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006247"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006247-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="303" mass="31080" checksum="CA452103F8E98B19" modified="2016-09-07" version="1">MFRRFSLFDAAPPSSTVSVSRPKPPPVPKSNGAVVVPEFRAPPRTDPINIAGSGVGDGGGVGGDGGDGGGSALASNGNRSPHLLRQGSSTSELLHLHQTPGHSPGSVGSASSATSAAAAVPPPPVGGGIRLLSSSPASYHRQSSISGSAPTNPSSALQQQLLYAAMHSRQPVNNVPVVQAAAAGAAATVTPGPVPNGGQPQTTAARERYSSGRSISSPVSPSQFADCPLSTSMPTSIKYYYTSPTWYSRFSHSLRKNVLRRSTSAHNSQNLPVADPFLEKVPLSDLEAAAAFPNLTDHAQPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHF1</accession>
    <name>A0A182PHF1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPPC13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHF1"/>
    <dbReference type="STRING" id="199890.A0A182PHF1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006360-RA">
        <property type="protein sequence ID" value="AEPI006360-PA"/>
        <property type="gene ID" value="AEPI006360"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006360"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055428">
        <property type="entry name" value="TRAPPC13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23643">
        <property type="entry name" value="TRAPPC13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="4">
        <location>
            <begin position="171"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 C-terminal" evidence="3">
        <location>
            <begin position="305"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006360-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="48145" checksum="E2325D39ADE3CE60" modified="2016-09-07" version="1">MVEPTEHLLALKVMRLTRPTLISPQILTAEPKDVPQYSFQKILHSDATSVAGCETIAAGQFMLLPQSFGNIYLGETFSSYVCVHNCRAHPVTNVSVKADLQSNNSRVSLPIHADKTGPVTLNPEETLDDVIHHEVKEIGTHILVCEVSYMTPAGLETSFRKFFKFQVVKPLDVKTKFYNAETDDVYLEAQIQNITVGPICLEKVELESSEQYTVVPLNTLPSGESVFSSKTMLQPQNSCQFLYCIRPISEIARDPSALKAANNIGKLDIVWRSNLGERGRLQTSQLQRCALEYSDLRLNVIEANSTVRIGEGFNFRCRVTNTSERSMDLLMSLNTKAKPGCGYTGVTEFALGPLEPGQMKEFPLTVCPVRLGLIVNSALQLTDVFTKRKYEFDNFLQVFVVDEDYREDNFQMDKYVRYSSSNKNIPQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHF8</accession>
    <name>A0A182PHF8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHF8"/>
    <dbReference type="STRING" id="199890.A0A182PHF8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006367-RA">
        <property type="protein sequence ID" value="AEPI006367-PA"/>
        <property type="gene ID" value="AEPI006367"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006367"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006367-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="156" mass="17469" checksum="00B8E850B11BFB47" modified="2016-09-07" version="1">MAESAALVPRSNGDSFCEEESLPSIPNDMSERLLDDSVLSVCGNEYGADEGSVRDWINYDELPLLNQQKQQQQQQQLPVPTDHISGRSSSIDVRVEFERCKNCQCEKFFPSNECLQEHMELNHRMIDETLPVMTTIPRVAYAEQEGSGPSGGYIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHI7</accession>
    <name>A0A182PHI7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4F5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHI7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006396-RA">
        <property type="protein sequence ID" value="AEPI006396-PA"/>
        <property type="gene ID" value="AEPI006396"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006396"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045230">
        <property type="entry name" value="MBS1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213">
        <property type="entry name" value="GEO09665P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006396-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="77" mass="8541" checksum="B56186A1BF21DBF7" modified="2016-09-07" version="1">MARGHQKIQSQQKAQEKAAKLKKQQGHGLSDQMKAAQKALVFSCAVCKSQMPDPKTYKQHFENKHPKAELPAELAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHL3</accession>
    <name>A0A182PHL3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHL3"/>
    <dbReference type="STRING" id="199890.A0A182PHL3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006422-RA">
        <property type="protein sequence ID" value="AEPI006422-PA"/>
        <property type="gene ID" value="AEPI006422"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006422"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000097">
        <property type="entry name" value="Probable chitinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF403">
        <property type="entry name" value="CHITINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="11"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006422-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="447" mass="49107" checksum="AEFEBCECF94D7367" modified="2016-09-07" version="1">MRTYLVTDHDRVVTCYISTWAVYRSGTASYPLDAFDPTLCTHAIYAFAGLDEEKNAIKSLDAWQDLKDNYGKGGFEKLTGMRAAHPHLKVLLAIGGWNEGSEKYSKLVANPERRQAFVKNALDFIRQYGFDGLDLDWEYPTQRGGTPADRENFVALVRELSQTFRKNNLLLTSAFGAGKDTIDAAYDVKALSKYLDFLHIMCYDYNGSWQGRISPNAPLTSRDVLNVEYTIEHLLQLGAPASKLVLGLPFYGRTFVSPVAKARLGDSSDKIGFSGPATKENGFMGYNEVCEELKRNPSDWMLEWDPAASEMVATKSNGTVSQVIVYDSTRSIANKVRFAVRQKLAGLMIWSVDTDDFNGLCAPEPDTYKDFGGTVVVSIPPPVSGKYPLLKTISNAVIVASDELTQENVIPDGPEEVPTTGPSAATLASGSSWLLGAVLFLVTARTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIH7</accession>
    <name>A0A182PIH7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIH7"/>
    <dbReference type="STRING" id="199890.A0A182PIH7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006739-RA">
        <property type="protein sequence ID" value="AEPI006739-PA"/>
        <property type="gene ID" value="AEPI006739"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006739"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="5"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006739-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="495" mass="55417" checksum="47C229241711877C" modified="2016-09-07" version="1">MPADGYSVLVTFPTGDFDGDTPFTLNPFQMVFKQKIIVVTVAYRLGIFGFFTSMDGEAPGNFGLMDQSAALLWIKRNIRLFNGNEGSVTILGHGTGAICVGLHLTSGDWTDDMFHKAILMSGSLLLDSSVRSAKQYASSLDELATAFGCFRRPTTKLMDCLRRVDAQILAENSPPIDWGPVIDQGLSNTTTPFIPDHPNMLVHQGKLRRVPLLIGHTDMEEVLELTMGDILEHGLGAEMFDTLLGDIVMSDLAEMEFNETLCGGNMDIVMEAVQYQYKPYPPTTDPLALRRKYIEFATERKYVAPTIELAMHMSQQADTFVYRFDIKPRTAAALKDVPEWVGVPHNFELIFLWGLPYWLTLADQMQWDSADKRVADIVMTLWANFAKFTNPTQVGVYIRWEKFTVTEPGVLIIDRSFNMSDHTTMSFDPVKFWNHYYPSVINFAAQCCNATYNGAERGAALSGSLVAGLLLTNLILLQSFIHHLRTTTHFVASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIZ8</accession>
    <name>A0A182PIZ8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anti_prolifrtn domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIZ8"/>
    <dbReference type="STRING" id="199890.A0A182PIZ8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006911-RA">
        <property type="protein sequence ID" value="AEPI006911-PA"/>
        <property type="gene ID" value="AEPI006911"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006911"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF22">
        <property type="entry name" value="BTG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01203">
        <property type="entry name" value="BTG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="3">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006911-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="299" mass="33820" checksum="E17EB3D52BE2C943" modified="2016-09-07" version="1">MRIEVNSAADFLMNLLRVRKANQLSESQLQHFKGSLEQILTRHFQCHWYPDVPTKGSGFRCLRINGKMDPIIEKAGHAVGLNTVVLRKLLPLELTIWIDPDEVSYRIGENGTICVLYDTAQSRASPSSDLDSTGSSSGMACDEFIMERVGRLDLSVSSVDSGNGSGGAMMVDYHLEQHSVSTKQQQHHNSNKYNHHHHQQQQQQQQQQHHYAKQRHSNSMSSSSSGQTSPPLSPPYGGGGFLNHQQNLARYQQQQQQQQHPHGPPQQQQHGGNNFYPSQPQQYFPWDNQFVNNKVRTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJC2</accession>
    <name>A0A182PJC2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJC2"/>
    <dbReference type="STRING" id="199890.A0A182PJC2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007036-RA">
        <property type="protein sequence ID" value="AEPI007036-PA"/>
        <property type="gene ID" value="AEPI007036"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007036"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051846">
        <property type="entry name" value="SH2_domain_adapters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127:SF32">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="814"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="626"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="912"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007036-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="973" mass="104098" checksum="E0EC766E27ED162E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJF6</accession>
    <name>A0A182PJF6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase-like protein 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJF6"/>
    <dbReference type="STRING" id="199890.A0A182PJF6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007070-RA">
        <property type="protein sequence ID" value="AEPI007070-PA"/>
        <property type="gene ID" value="AEPI007070"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007070"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007070-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35596" checksum="B83ACD85E1100A5A" modified="2016-09-07" version="1">MAIFGHDLEISSVVARSVTSPWYTVFENYASIQNKLPSRPDEIPLTNNKKALEFVDHFNDSSHYVADGRFRGQNSTERTIVTELEGETFLIPPRVTFINSSIDRFAEYIDQNDKFDLIVLDPPWWNKYIRRVKAVNTKAGYRMLTNEDIKAIPLQSHLHENTLVVVWCTNAPSHIDAVAKDFFPKWGVELVASWYWIKITTNGQPVCKFNEPNQKQPYERIFVGLPGGSTLVKSFPRERFLYSTPSAIHSHKPPLYDLFTSKFVPQEATCLELFARSLYPGCTSYGMEVLKLQNKRLYELAMEDGDDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK05</accession>
    <name>A0A182PK05_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D7 protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PK05"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007271-RA">
        <property type="protein sequence ID" value="AEPI007271-PA"/>
        <property type="gene ID" value="AEPI007271"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007271"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF43">
        <property type="entry name" value="GEO07291P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131445" description="D7 protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007271-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="36069" checksum="D812E69AD8C98220" modified="2016-09-07" version="1">MVTVALESVITFGVVLLLALVVSGSPLETQCPLIRSAETANRPAVWQPRTPEQTLYAYVRCLNDSSASIEMKIRWVMWQPDQSPESQCYVKCVSEDLRLYDPARRQFVPERFEQQARAFHDDPESDDIRPLYGDAARLLTGELPDNECATVFAKYAPFYAVHQEHILDIFHGDLRKILVTYKRLGSRVKQIGQSFVDYCEKRYGFVWAEEEQRPCPNRTAIECVFHGFRWITEEGSVNVAEIIRDFEGFGVKASELGQCQVADDLYWCLRALNADKLSAVIQQRNAQTAFYFDQSSEDEPWKSAVEFGNSRLNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK51</accession>
    <name>A0A182PK51_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF866 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PK51"/>
    <dbReference type="STRING" id="199890.A0A182PK51"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007317-RA">
        <property type="protein sequence ID" value="AEPI007317-PA"/>
        <property type="gene ID" value="AEPI007317"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007317"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007317-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19054" checksum="ADD869A1D9713321" modified="2016-09-07" version="1">MGKIGLQIKATLENIEELKTNHPNYAFFLKIKCTNCGEASDKWHDLTESEHTNEDSRNPKGFNFYMKCRMCSRENSIDIIEGSNGGYYASYTEQDSGKKKTIVAFDCRGVEPIEFSPRAGWVAKATENGPTFEDIDLSEDDWVEYDQKNNNSVGVYEFESGFIKMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKT3</accession>
    <name>A0A182PKT3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-binding cassette sub-family F member 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKT3"/>
    <dbReference type="STRING" id="199890.A0A182PKT3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007550-RA">
        <property type="protein sequence ID" value="AEPI007550-PA"/>
        <property type="gene ID" value="AEPI007550"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007550"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000467">
        <property type="entry name" value="ATP-binding cassette sub-family F member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="75"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="387"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007550-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="615" mass="69492" checksum="E9004991078A915F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL94</accession>
    <name>A0A182PL94_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KxDL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KXD1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PL94"/>
    <dbReference type="STRING" id="199890.A0A182PL94"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007711-RA">
        <property type="protein sequence ID" value="AEPI007711-PA"/>
        <property type="gene ID" value="AEPI007711"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007711"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039843">
        <property type="entry name" value="KXD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13511">
        <property type="entry name" value="KXDL MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13511:SF0">
        <property type="entry name" value="KXDL MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KxDL" evidence="3">
        <location>
            <begin position="37"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007711-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="259" mass="28224" checksum="A845479F8758DC71" modified="2016-09-07" version="1">MMNSEMSSSMHSGRPESDFSIECFQNYTAPEVFVQGLAGLVNQTDVEVMIRAQKQMLQRFEKTNEMLLNCNALSASRLKIATDDFKKHTKLLHDMKKDLDYIFRKIRTIKTKIGNQYPAAFAEAEAKNKPISFDEEDEIDTASRAETLDEKKDGVHDGGTPSVATPVKVSSGAKEKPSTSKAEGTVEGGGPKERKKALASGSRENSTVGYVKMEQSPENRKSGAGGGSSGEQKRRSFRSAQSSSTDNSNDSSDCTSDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLD5</accession>
    <name>A0A182PLD5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:11333"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TENT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PLD5"/>
    <dbReference type="STRING" id="199890.A0A182PLD5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007753-RA">
        <property type="protein sequence ID" value="AEPI007753-PA"/>
        <property type="gene ID" value="AEPI007753"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007753"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012937">
        <property type="entry name" value="TET5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974:SF36">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07984">
        <property type="entry name" value="NTP_transf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01153">
        <property type="entry name" value="DUF1693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="68"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="537"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007753-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="610" mass="67519" checksum="6C1A3BB3CE44EDC8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN89</accession>
    <name>A0A182PN89_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RPGRIP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PN89"/>
    <dbReference type="STRING" id="199890.A0A182PN89"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008414-RA">
        <property type="protein sequence ID" value="AEPI008414-PA"/>
        <property type="gene ID" value="AEPI008414"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008414"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041091">
        <property type="entry name" value="RPGRIP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031139">
        <property type="entry name" value="RPGRIP1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240:SF1">
        <property type="entry name" value="PROTEIN FANTOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240">
        <property type="entry name" value="RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18111">
        <property type="entry name" value="RPGR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPGRIP1 C-terminal" evidence="3">
        <location>
            <begin position="814"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="347"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008414-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="987" mass="113344" checksum="80B298A7E2F0D05F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNL5</accession>
    <name>A0A182PNL5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="11">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182PNL5"/>
    <dbReference type="STRING" id="199890.A0A182PNL5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008542-RA">
        <property type="protein sequence ID" value="AEPI008542-PA"/>
        <property type="gene ID" value="AEPI008542"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008542"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000001">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="14">
        <location>
            <begin position="325"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="470"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008542-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="890" mass="101137" checksum="CE76BE2C2925183D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNT7</accession>
    <name>A0A182PNT7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C45 hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNT7"/>
    <dbReference type="STRING" id="199890.A0A182PNT7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008616-RA">
        <property type="protein sequence ID" value="AEPI008616-PA"/>
        <property type="gene ID" value="AEPI008616"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008616"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008616-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="383" mass="42494" checksum="A2E1A0F2F25E51D7" modified="2016-09-07" version="1">MVAPADLERRDAIPVLYTRGTHYSVGYDVGRTFASIIHSFLEKSVPLNETYLPLFNTENGRKIYVDTYESVNKSFPQYIRELQGIADGAKVEFHKLFLLHIDDVITGGQDGNNQPIGCSTICVNEPDCVVLGHTEDALSEVLNHFYFVSAHIISEKPEGKHKVVEERFTSLCYAGHLPGYTMNANHHGLVFSINTLSAKTLVGGKTPRHFITRALLAAENFVQAQEILRDHGVGAADGCSINMTFLKQEGDRLFHNAEMGPATHGDESQLNILTASPGEHIIHVNSYQRLPVPEVTGLIIDSSVERMKTFAKYAPPKTVADVVQMLSDVTATEHKVFRDHGKNQKVKTICVGIIDCIKRTWTLYAENPAYVPPLVVLPLMLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP33</accession>
    <name>A0A182PP33_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="5 18">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 18"/>
    <dbReference type="AlphaFoldDB" id="A0A182PP33"/>
    <dbReference type="STRING" id="199890.A0A182PP33"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008712-RA">
        <property type="protein sequence ID" value="AEPI008712-PA"/>
        <property type="gene ID" value="AEPI008712"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008712"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000043">
        <property type="entry name" value="pre-mRNA-processing factor 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24814">
        <property type="entry name" value="WD40_Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 18" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14 18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 18" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 17" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="19">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="485"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008712-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="519" mass="56937" checksum="5DB8EA5B75897089" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPA1</accession>
    <name>A0A182PPA1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPA1"/>
    <dbReference type="STRING" id="199890.A0A182PPA1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008780-RA">
        <property type="protein sequence ID" value="AEPI008780-PA"/>
        <property type="gene ID" value="AEPI008780"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008780"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008780-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="67" mass="6639" checksum="FBD690F5801D2550" modified="2016-09-07" version="1">MAAVGGPARQSRGVSMSVSMSLVQGGAAGAPQGAILAAAAPYFQPPAVPQDVQPDRPIGYGAFGVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPB7</accession>
    <name>A0A182PPB7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PPB7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008796-RA">
        <property type="protein sequence ID" value="AEPI008796-PA"/>
        <property type="gene ID" value="AEPI008796"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008796"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.130">
        <property type="entry name" value="Ubiquitin-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="1389"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1092"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1520"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1566"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1763"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1816"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="188"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="343"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1092"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1138"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1526"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1537"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1566"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1816"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1826"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1882"/>
            <end position="1894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008796-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1894" mass="210009" checksum="880F43810B843BC2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPH9</accession>
    <name>A0A182PPH9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPH9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008858-RA">
        <property type="protein sequence ID" value="AEPI008858-PA"/>
        <property type="gene ID" value="AEPI008858"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008858"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898">
        <property type="entry name" value="DAEDALUS ON 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898:SF1">
        <property type="entry name" value="MD-2-RELATED LIPID-RECOGNITION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00697">
        <property type="entry name" value="DM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131612" description="MD-2-related lipid-recognition domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008858-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20642" checksum="E82727925D94C378" modified="2016-09-07" version="1">MLKQCILLVLVVQLIDKSAAVVRFENLKYELNKDYMHGNIFIKSQNDKYSFGADVELTKKVEGSVIITPHVQHLVKGEYHTMVNIDLDTCKVDPVMSENAIVRTIAKESTKFINFSLMCPYNPGRYLLNDFTLDSESPLLKLIPNGKYKMELKAHHYPTPDSAPIMLFMYSIDFELFAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPK3</accession>
    <name>A0A182PPK3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol(in) = cholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:39747"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PPK3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008882-RA">
        <property type="protein sequence ID" value="AEPI008882-PA"/>
        <property type="gene ID" value="AEPI008882"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008882"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030301">
        <property type="term" value="P:cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000010">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004765">
        <property type="entry name" value="NPC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00917">
        <property type="entry name" value="2A060601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="812"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1162"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1186"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1211"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1257"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1288"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="18">
        <location>
            <begin position="671"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="319"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1354"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1472"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1374"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1407"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1432"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1492"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1503"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1537"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1547"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1565"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1588"/>
            <end position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008882-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1611" mass="177300" checksum="2133E3D5D8D39DC5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPR6</accession>
    <name>A0A182PPR6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPR6"/>
    <dbReference type="STRING" id="199890.A0A182PPR6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008945-RA">
        <property type="protein sequence ID" value="AEPI008945-PA"/>
        <property type="gene ID" value="AEPI008945"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008945"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000020">
        <property type="entry name" value="Potassium voltage-gated channel protein Shaw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF278">
        <property type="entry name" value="SHAW-LIKE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="15">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008945-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="505" mass="56321" checksum="8563D16FCAF7A258" modified="2016-09-07" version="1">MFFLTSHSSVESDEESIKYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSVHRDTQSTLAILDKLELDDEQPSEEAIARLFGFEEALLNGELTCWQRTKPKIWALFDEPSSSTGAKIVAGISVFFICISVISFCLKTHPGLRVEIPAILNITTNGTASVLPDELPTTLDELLDHGRLDDLMLDYSSPTGISSASTASTITTTTSATTESHSASPTRPETTTQRTGRIVSSAYRMNSGKGASIVENWQETYGQPHEAFFYVELVCNVWFIIELTVRLVVTPNIVEFIKSPVNIIDLAATLSFYTDVCQRMGEQTGLLEAFSIVRILRLFKLTRHSPGLRILIHTFKASARELTLLVFFLVLGIVVFASLVYYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDMAPKTYVGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPT1</accession>
    <name>A0A182PPT1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPT1"/>
    <dbReference type="STRING" id="199890.A0A182PPT1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008961-RA">
        <property type="protein sequence ID" value="AEPI008961-PA"/>
        <property type="gene ID" value="AEPI008961"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008961"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF147">
        <property type="entry name" value="EG:BACR7A4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="354"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008961-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="589" mass="65800" checksum="9F21B564F6D0A015" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQB8</accession>
    <name>A0A182PQB8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin carboxyl-terminal hydrolase 36</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Deubiquitinating enzyme 36</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protein scrawny</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin thioesterase 36</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin-specific-processing protease 36</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PQB8"/>
    <dbReference type="STRING" id="199890.A0A182PQB8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009148-RA">
        <property type="protein sequence ID" value="AEPI009148-PA"/>
        <property type="gene ID" value="AEPI009148"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009148"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000085">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="257"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="584"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="696"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1070"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="711"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="806"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="835"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="857"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="923"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="953"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1084"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1131"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1144"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1176"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009148-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1251" mass="130172" checksum="2062AF36422928CE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQL8</accession>
    <name>A0A182PQL8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hyccin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Hyccin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQL8"/>
    <dbReference type="STRING" id="199890.A0A182PQL8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009249-RA">
        <property type="protein sequence ID" value="AEPI009249-PA"/>
        <property type="gene ID" value="AEPI009249"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009249"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018619">
        <property type="entry name" value="Hyccin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220:SF1">
        <property type="entry name" value="GH21176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220">
        <property type="entry name" value="HYCCIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09790">
        <property type="entry name" value="Hyccin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009249-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39235" checksum="0C055EB30AA2B96A" modified="2016-09-07" version="1">MAEAIIADWISDYSSLQESELRTFAAQHENDFEISKALYSILNERTKYKDLIHPICNQLCNFYRSNEAELRRFTLQFVPMLIYLYLNSVALGDKKGCRSIETLLICIYNIEVSSDDGSPKVVSFRMPVLAQASVYHEEKSLQPSDLRRWEENSNKDINWGPLPSIESINAQNRLKVMTALLFTYNQQLNQIHKPALYHLCKTTSLLVNQGFPKLPGGHMHRSSYGNDPISPQQPMAMAAPSHVVRPPPRIAVNAQFLVELAHANYFAMFNEFASAAMEAVTDLHSRACYEMLPEVILVTNAIRNSLHANPSGQPSDGPMGISVALTPATTTVTVSKSMITNASFRTKKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR70</accession>
    <name>A0A182PR70_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PR70"/>
    <dbReference type="STRING" id="199890.A0A182PR70"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009452-RA">
        <property type="protein sequence ID" value="AEPI009452-PA"/>
        <property type="gene ID" value="AEPI009452"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009452"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="352"/>
            <end position="372"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009452-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="385" mass="44225" checksum="55366B60183CF8CF" modified="2016-09-07" version="1">MDLLKQAKNLKLLIPTSSTDWWVQFRKWEELCCPKQPTVRLVLLFSFFLIMELSVFILTLVYIPSRMHTSSFFLDNGVPAILIIGTTGSVVKLSHMFSQRKRFGVISSALQHFDQTLQRLDFQLRCDEVLYWTAGWSLSFGITTLFFSVAVHVFGCVVFKHVGPFLMVVFLNITNIPYIVFMVWFILLEICVWCRLKLLHSLIDSGMRLAITGKRMGISKRPNHLLAGLSDLHAELSSVVGHISAAFGVQITVSLCAYTILLIFCIFSYYRAAVVMGEIETNFAWLTVCWSLYNSCFMIPMILFGAFIRQSSDKLTTQVHHHLRHASELVIQNQQMDHYSFAIHPWFYTIEWSVYALVIGYVSTYVVILIQFDSKTLDISRAHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR73</accession>
    <name>A0A182PR73_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TRASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PR73"/>
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        <property type="protein sequence ID" value="AEPI009455-PA"/>
        <property type="gene ID" value="AEPI009455"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009455"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057926">
        <property type="entry name" value="QRICH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051284">
        <property type="entry name" value="ZnF_MYMT-QRICH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45736:SF1">
        <property type="entry name" value="WITHOUT CHILDREN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45736">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25561">
        <property type="entry name" value="QRICH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
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        <location>
            <begin position="570"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="5">
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        </location>
    </feature>
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            <begin position="10"/>
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        </location>
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            <begin position="83"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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        </location>
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        <location>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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        <location>
            <begin position="1082"/>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        <location>
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        <location>
            <begin position="1405"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009455-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1770" mass="197308" checksum="710A789DC94DD545" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR98</accession>
    <name>A0A182PR98_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">YLP motif-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Nuclear protein ZAP3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with PPP1CA and NCOA5. Forms a complex with ILF2, ILF3, KHDRBS1, RBMX, NCOA5 and PPP1CA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PR98"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009480-RA">
        <property type="protein sequence ID" value="AEPI009480-PA"/>
        <property type="gene ID" value="AEPI009480"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009480"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000399">
        <property type="entry name" value="YLP motif containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058903">
        <property type="entry name" value="Spectrin_YLPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026314">
        <property type="entry name" value="YLP_motif_con_p1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413">
        <property type="entry name" value="YLP MOTIF CONTAINING PROTEIN NUCLEAR PROTEIN ZAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413:SF0">
        <property type="entry name" value="YLP MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26583">
        <property type="entry name" value="Spectrin_YLPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="YLPM1-like spectrin repeat" evidence="16">
        <location>
            <begin position="137"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
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            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
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            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
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            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
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            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="971"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1352"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="720"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="794"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="853"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="911"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="971"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="998"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1013"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1356"/>
            <end position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF26583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009480-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1374" mass="155104" checksum="F514BC5821E7B848" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRD7</accession>
    <name>A0A182PRD7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRD7"/>
    <dbReference type="STRING" id="199890.A0A182PRD7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009521-RA">
        <property type="protein sequence ID" value="AEPI009521-PA"/>
        <property type="gene ID" value="AEPI009521"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009521"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF166">
        <property type="entry name" value="LD40136P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="112"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009521-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="330" mass="38319" checksum="31C77DB54028F828" modified="2016-09-07" version="1">MQDRCPMTNKIDLSKAPESYAPYSFNLSDKYKIMAQDELREDDDMRENALKQFREWIAKHPLIRKCRTDAPFLLRFLRTKKFSIPAATEMLEKYLTIRQVYPNWFFKLDINDPDLEAIIDSGYLFALPERDEHGRKIIFSNAGKFDTSRFTSAQLIKIHSMVLEALQDEEESQISGYIHVTDDSELNIGFLSIWSFTDIRNLAHCVQNSLPMRQKENHFVNLPSFANKLSEFILSVLSEKLRNRVFVHRGWDELKTKINPKLLPKEYGGTVPMAECIAQFKKQLKERRDIVLALDEMEIEINKSTIPWADSTDADIASGVIGSFRKLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRH3</accession>
    <name>A0A182PRH3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Microsomal signal peptidase 12 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRH3"/>
    <dbReference type="STRING" id="199890.A0A182PRH3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009557-RA">
        <property type="protein sequence ID" value="AEPI009557-PA"/>
        <property type="gene ID" value="AEPI009557"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009557"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009557-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="96" mass="10913" checksum="0D7DEB5881A1B956" modified="2016-09-07" version="1">MLNIATHMDFEGQGRAEKLSRIIITLFGTVGLVWGYIIQQFSQTVYILIAGVLLASILTIPPWPIYRKKPLNWQKPRPDSQTTQSAADETKKKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRN7</accession>
    <name>A0A182PRN7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 13">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp. Interaction of RABGGTB with prenylated PTP4A2 precludes its association with RABGGTA and inhibits enzyme activity. Interacts with CHODL. Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 13"/>
    <dbReference type="AlphaFoldDB" id="A0A182PRN7"/>
    <dbReference type="STRING" id="199890.A0A182PRN7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009622-RA">
        <property type="protein sequence ID" value="AEPI009622-PA"/>
        <property type="gene ID" value="AEPI009622"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009622"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000004">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 13" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="14">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009622-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="331" mass="36854" checksum="27D84960691DE6C3" modified="2016-09-07" version="1">AFTSNDVSITDDSKQLYFGKHVDYIANHGNDKNDYEYCMTEFLRMSGIYWGVTGLDLMNELSRLDKGSIIEFIKKCQCPVTGGIAACEGHDPHMLYTLSAVQILVIYDCLDAIDTELVAKYVASLQQLDGSFFGDKWGEVDTRFSFCAVAILSLIGRMDVMGVEKAVNFVMSCCNSDGGFGSKPNAESHAGLIYCCVGFLSITDQLHRLDCERLAWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLTIIGRLHWISSEKLENFILSCQDAETGGFADRTGNMPDIFHTLFGLGALSLLGDKRLKPVNPTFCMPQYVIERCNLKPQVIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSD9</accession>
    <name>A0A182PSD9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSD9"/>
    <dbReference type="STRING" id="199890.A0A182PSD9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009874-RA">
        <property type="protein sequence ID" value="AEPI009874-PA"/>
        <property type="gene ID" value="AEPI009874"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009874"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF304">
        <property type="entry name" value="DNA-BINDING PROTEIN D-ETS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009874-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="72" mass="8176" checksum="697C7D2A249AE1BF" modified="2016-09-07" version="1">MPASDITSGSGQIQLWQFLLELLSDSTNATCITWEGTNGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSI3</accession>
    <name>A0A182PSI3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A182PSI3"/>
    <dbReference type="STRING" id="199890.A0A182PSI3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009918-RA">
        <property type="protein sequence ID" value="AEPI009918-PA"/>
        <property type="gene ID" value="AEPI009918"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009918"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000001">
        <property type="entry name" value="Sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009918-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="541" mass="59995" checksum="65330942E18EAC65" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSV1</accession>
    <name>A0A182PSV1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methionyl-tRNA formyltransferase, mitochondrial</fullName>
            <ecNumber evidence="3">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Methionyl-tRNA formyltransferase that formylates methionyl-tRNA in mitochondria and is crucial for translation initiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-methionyl-tRNA(fMet) + (6R)-10-formyltetrahydrofolate = N-formyl-L-methionyl-tRNA(fMet) + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:24381"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PSV1"/>
    <dbReference type="STRING" id="199890.A0A182PSV1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010037-RA">
        <property type="protein sequence ID" value="AEPI010037-PA"/>
        <property type="gene ID" value="AEPI010037"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010037"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12230:FF:000003">
        <property type="entry name" value="methionyl-tRNA formyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="11">
        <location>
            <begin position="102"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="12">
        <location>
            <begin position="227"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010037-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="344" mass="38441" checksum="D4965792741575A3" modified="2016-09-07" version="1">MLLLTRVHVRTAIFSSITNTSNVQRYFSNVSRLKVLFFGTDHFSLPSLKSIHKNLINNGRVERLEVVTSFKAAKNPVKQYSRTAGIPMHDWVACTPGIARTFDLGVVVSFGHLIPETFINSFDRGMLNVHASLLPKLRGAAPIVHAIANGEQRTGISIMRIKPKQFDVGEILLQSSVSIGRDTLMPQLHDELAAIGADCLITCIEDLESYYQRLTVQNDTEATYAPKIDQKFAEIRWQDSTAVNVYDRYRSLYGLRPLLTTFGGEVVKIFKLSCNSDNQPVPPISPRPGQLEYSKRSKQLSVRCGDGRSLAILQLSVGGKKTLTGQDFYNGFLSKVNPSERYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSW9</accession>
    <name>A0A182PSW9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 12</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSW9"/>
    <dbReference type="STRING" id="199890.A0A182PSW9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010055-RA">
        <property type="protein sequence ID" value="AEPI010055-PA"/>
        <property type="gene ID" value="AEPI010055"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010055"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="8">
        <location>
            <begin position="53"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010055-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="156" mass="16846" checksum="81A8C38773E3DC9D" modified="2016-09-07" version="1">MASPSQSSPATAVTANAVGGSSGTKVSTGGSSSAGTTSSSGGSGTDSATQLLTKPRLQELVREIDPTEQLDEEVEELLLQIADDFVENTVNAACLLAKHRKVPKVEVRDVQLHLERNWNMWIPGFGTDELRPYKRATVTEAHKQRLALIRKAIKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSX0</accession>
    <name>A0A182PSX0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PSX0"/>
    <dbReference type="STRING" id="199890.A0A182PSX0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010056-RA">
        <property type="protein sequence ID" value="AEPI010056-PA"/>
        <property type="gene ID" value="AEPI010056"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010056"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131719" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010056-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="138" mass="15217" checksum="618A7C591295DFD7" modified="2016-09-07" version="1">MHRTSCMFLLCLAGLALVQSVNADGKLKIGVKKRVENCTVRTKKGDLVHMHYTGTLEDGTEFDSSIPRGNPLTFTLGMGQVIKGWDQGLLGMCEGEKRKLVIPPELGYGERGAGEKIPPNSVLIFEVELMKIERKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PT31</accession>
    <name>A0A182PT31_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PT31"/>
    <dbReference type="STRING" id="199890.A0A182PT31"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010117-RA">
        <property type="protein sequence ID" value="AEPI010117-PA"/>
        <property type="gene ID" value="AEPI010117"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010117"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010117-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="397" mass="43095" checksum="75FB6DE6AC8B8429" modified="2016-09-07" version="1">MTSSKLRIKDDLYNRLSPVQPNEMLYKESNKSRSSSTFFHAVGYRQHDSSEELARYSGAVPSQVKTDAQRSSPSPNQTASTTVTLHDDDNHSNATTEMPPNKSALILQAHFYQNLFAASATLFKQQRPAKRRRVHVSANHFDEASNHSEDEAGIDEKAEDLSSPLETALASVGQFPKGLFPNALSPNERQDGGRTADPHVEMDRDVDTSESNEMLEKPSNAFPWLSEATNNNDYTKGNNNHHGTPPHLHHPHHPHHHHHHHHHPHHSHHLAASSASTASATQSSLGPASTGNCRHGHHGEDSKCRALNCGGPPPSPSAGSSLAANEGATPDSSSTTATATAIPNFNQMPVPGGVQGQNPTQGLVHWMSAVMAEHMTSNPHHDPAAVGMHYMWNGPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PT56</accession>
    <name>A0A182PT56_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer and homodimer. Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182PT56"/>
    <dbReference type="STRING" id="199890.A0A182PT56"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010142-RA">
        <property type="protein sequence ID" value="AEPI010142-PA"/>
        <property type="gene ID" value="AEPI010142"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010142"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010142-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="174" mass="20282" checksum="4FA2B347C02EADEE" modified="2016-09-07" version="1">MTVLPNILVTGTPGTGKSELCRQLADKLGFRWQNVSDIVTEHEFVEEYDEEFECPVLDEDRLLDHLEPLMQQGGSVVEYHSSEFFPERWFASVWVVRCSTSLLYDRLRAREYGDRKIKSNMECEIFQIPLDEARLAYRDSIVFELTSDTAADLEANVERVSDWLEQWKAKHNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTC7</accession>
    <name>A0A182PTC7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182PTC7"/>
    <dbReference type="STRING" id="199890.A0A182PTC7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010213-RA">
        <property type="protein sequence ID" value="AEPI010213-PA"/>
        <property type="gene ID" value="AEPI010213"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010213"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="143"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="346"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="492"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="615"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010213-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="719" mass="79005" checksum="F2955D4698020BF6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU00</accession>
    <name>A0A182PU00_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PU00"/>
    <dbReference type="STRING" id="199890.A0A182PU00"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010436-RA">
        <property type="protein sequence ID" value="AEPI010436-PA"/>
        <property type="gene ID" value="AEPI010436"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010436"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15583">
        <property type="entry name" value="PHD_ash2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.980.20:FF:000005">
        <property type="entry name" value="Set1/Ash2 histone methyltransferase complex subunit ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049455">
        <property type="entry name" value="ASH2-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053835">
        <property type="entry name" value="ASH2L-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21198">
        <property type="entry name" value="ASH2L-like_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21257">
        <property type="entry name" value="PHD_ash2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="262"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010436-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="530" mass="60408" checksum="93DB9E09B4E8D9E9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUR5</accession>
    <name>A0A182PUR5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUR5"/>
    <dbReference type="STRING" id="199890.A0A182PUR5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010702-RA">
        <property type="protein sequence ID" value="AEPI010702-PA"/>
        <property type="gene ID" value="AEPI010702"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010702"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004994">
        <property type="term" value="F:somatostatin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000231">
        <property type="entry name" value="Allatostatin C receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000586">
        <property type="entry name" value="Somatstn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00246">
        <property type="entry name" value="SOMATOSTATNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="71"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="361"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010702-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="503" mass="55396" checksum="6D50401D97670E62" modified="2016-09-07" version="1">MEEGNTTSFFLLGEFNSLTDQNVSQFGIYLEETEPNDTFMGNFTCPPTDMPTTYYLFMFLYAVVCLVGVLGNTLVIYVVLRFSNMQTVTNMYILNLAIADECFLIGIPFLIATMHMKRWTLGGAMCKAYMVSTSVTQFTSSIFLFIMSADRYIAICHHISSPKYRTPLVSRIVSLLAWLASALIMLPIMIYADVIEQKPNTYSCQILWPETHGHLPGYTFTLYSLILGFVIPLCFIMTFYCLVIRKLRNVGPKTTGKSRGKRRSHRKVTKLVLTVITVYILCWLPYWISQVALITSDFETCSTRLDLILFLLVGCLGYINSAINPILYAYLSENFKKSFLKACTCAARAEVNAQLKLENSVMPKRSRTRTNSDTTQLTTGSKVQHRLLVEPTTTATTTTTAASCVSSRNPSPPPAPTQRNNHLLTVPGTSPACPSTNGGSNHNNNNDINTIGTNGTGTGYLHASNGNTGSGKGLDCSASPSDGNEALSVSCGHGLDEQLVKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUW6</accession>
    <name>A0A182PUW6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUW6"/>
    <dbReference type="STRING" id="199890.A0A182PUW6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010753-RA">
        <property type="protein sequence ID" value="AEPI010753-PA"/>
        <property type="gene ID" value="AEPI010753"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010753"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002290">
        <property type="entry name" value="Weckle, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="158"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="445"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="97"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010753-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="57564" checksum="91930B0F4370CC85" modified="2016-09-07" version="1">MQTSWQNWCRLCADEKALLKLESVHDVNAVIGNLFNVSLIEIVDVQANICEDCLTFVNKLEHFKERCERTNRLFAYMVEATREISQPLDMKQVRSRFLDEENVNDEQEALCDDLEEKTKEDANAEVFYQMEAVTIATAQNEIESEQWELLEVEMDNCSKDMGTNNEDVEENEEDEEYDKMSDSDYEPETSALTRSATNCEQSSVVDWKPTSEFEENDESLASKQPERRKISSNKNIINQLFKCSQCPKSFSTQSHLKRHENGHLQGDGKPRYSCHLCHKVFTKSANRKTHMRLMHEGEKPFICEECGKPFSSKSALKEHYIVHTEDRPFQCAYCSKSFKNAVRLKTHEDTHNDTLYVCTYCGLKLNTKRTLNMHMVVHSDQKKFKCQECGNEYKRSKALKAHLILHTGLRPYQCPFCDKTFANGSNCRSHKKKFHPRELAALEAAGGQKPTANIPKLEQLQRKSQSDGEVVEITRKHIRSSPRATNSSKVKTKLDDQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVD0</accession>
    <name>A0A182PVD0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVD0"/>
    <dbReference type="STRING" id="199890.A0A182PVD0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010917-RA">
        <property type="protein sequence ID" value="AEPI010917-PA"/>
        <property type="gene ID" value="AEPI010917"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010917"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF49">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010917-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="58966" checksum="44BD4DFFD0EC3BEB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVE8</accession>
    <name>A0A182PVE8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVE8"/>
    <dbReference type="STRING" id="199890.A0A182PVE8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010935-RA">
        <property type="protein sequence ID" value="AEPI010935-PA"/>
        <property type="gene ID" value="AEPI010935"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010935"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF336">
        <property type="entry name" value="LP19554P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="327"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="428"/>
        </location>
    </feature>
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        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="6"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010935-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="487" mass="53727" checksum="26731EEA53423CA1" modified="2016-09-07" version="1">MIVTVMIFVACTASFMLRVHMSINLLAMIQPITASSNNSVIVTNSTVAFNASQEFVNKTLMKDENLIVPAQTPPDYGPRYVWKQNMQSHILGAYFYGYLLTSLPAGPLAERYGPRRLVGYSFVLCAFVTALFPLFAAIDVWCVIAGRFLIGFLSGFVYPTLHNVISRWIPPNEKSKAVACIAGGSTFGTVITWPFAGLLTEHFGWVYAFYVPALLSASVGFIWFWLIADSPSEHKTITKEERDLIEASFGDTVSKTKATPPLGKVVTSLPFIALVLSHYSSFWGLNFFVTQAPKFINEVLGFNLTNAGFLSSLPYLARMFSGFFFGYIGDGLRKNEVMTVTALRKSFIVFSHFLPGAFLIALPFIAQDPIVTVSCIIACLGFNGASTITNLVNAQDLAPNFAATLYGMMNFLATTAGFLAPMTVAFFTEQRNTMEEWKHVFLLTAGFYIASGIVFIIFGTGKVQKWNEIKENSAEKQSEPEVLTVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW56</accession>
    <name>A0A182PW56_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PW56"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011193-RA">
        <property type="protein sequence ID" value="AEPI011193-PA"/>
        <property type="gene ID" value="AEPI011193"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011193"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031754">
        <property type="entry name" value="DUF4736"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15883">
        <property type="entry name" value="DUF4736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011193-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="209" mass="23933" checksum="DBA3BDD8679C9E23" modified="2016-09-07" version="1">MAIVLQFCHTLLIKLHRFLLRNHQRLLFTSLLIGMTTATAHWQSIRHPALLDHFHENLRTFPVQISFGAVALLSAGALVSYSLYRHHVRGKERRARIAIRQRYIDYIVLCLMVSVANAARQHLHCPDKAGLGLSQLEGYRHDVQVAIARFRASARKLLQEPPLPLANSHTFLERYFRLDDDRFGEEILALKRDAGSLMNVPAMKGLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWP7</accession>
    <name>A0A182PWP7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">39S ribosomal protein L38, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWP7"/>
    <dbReference type="STRING" id="199890.A0A182PWP7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011384-RA">
        <property type="protein sequence ID" value="AEPI011384-PA"/>
        <property type="gene ID" value="AEPI011384"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011384"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000002">
        <property type="entry name" value="39S ribosomal protein L38, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF133">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011384-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="311" mass="36930" checksum="E94D4C4DB75E3D3E" modified="2016-09-07" version="1">QIHIDQVRIDWLETNGPFHIKQIAEHYGVYEHLFGNAFFVPRVALNIQYQCGESLHHVRFGNILKPSETQLPPRVQFDANINLTCNSKGKDVQSLWSLLLTNPDGHFEQNEKEYCHWFVGNIPNGDLKSGDELIPYLQPFPAKATGYQRYIFILYKQTNRINFSQYRQIDPYDLPARTFRTLDFYRQYQDHITPAGLAFFQSDWDASLPEFYHKKLQLQHPVFEYHFPASYIREQEWFPLRKPFNTYMDKYRDSALIRKEYLIRKFANTHPFEESEAPLRFPNAHPINDVPSWLGTEIRKDRLGWGRINDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWR6</accession>
    <name>A0A182PWR6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Galactokinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWR6"/>
    <dbReference type="STRING" id="199890.A0A182PWR6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011403-RA">
        <property type="protein sequence ID" value="AEPI011403-PA"/>
        <property type="gene ID" value="AEPI011403"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011403"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000153">
        <property type="entry name" value="AGAP005013-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3170:FF:000003">
        <property type="entry name" value="Galactokinase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000001">
        <property type="entry name" value="N-acetylgalactosamine kinase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="6">
        <location>
            <begin position="129"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="7">
        <location>
            <begin position="365"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011403-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="52734" checksum="AF63570AE85E7C72" modified="2016-09-07" version="1">MASDRGALCVEVLEAVPECKRLSRLLECFSNEFARRPSFVVRCSGRVNIIGEHVDYCGYPVFPMAIEQTILLAVAPSDDNLLHIKNADNNFKPYKCNVLTYSIDVPTVGGPHWYQYVLCGVKGILENSTIQHDSPRGMMILLSGNIPPASGLSSSSAIVSATVLATAYMHNATLNKQTLATISAECEKFIGTQGGGMDQAIAYLAQEGCAQLIEWNPLRATPIQLPENAVFVIANSLSEANKAATSDFNQRVVECRLASRLLAKQMKLNWRDLNRFADLQKALGYSLEQMVSLVHANLGLNVYTRTELITLLEVTEEDFADNLLTPNTRNSQTFKLRQRALHVFQEALRVQQFIETAKSTSEDCISRMKTLMKQSHESLRTLYECSHDNLDRIVAISDRLGVGTRLTGAGWGGCVVALCDGVEESKRFVETLKTEFYTSIPKAQGCDIGSVCFTTSPQRGAEIYLIDKHQNIWTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX07</accession>
    <name>A0A182PX07_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="2">6.3.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PX07"/>
    <dbReference type="STRING" id="199890.A0A182PX07"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011494-RA">
        <property type="protein sequence ID" value="AEPI011494-PA"/>
        <property type="gene ID" value="AEPI011494"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011494"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurM-like C-terminal" evidence="7">
        <location>
            <begin position="41"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="6">
        <location>
            <begin position="188"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="6">
        <location>
            <begin position="273"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011494-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="369" mass="39520" checksum="5333C92827100EBB" modified="2016-09-07" version="1">MSAKVVEGNSALGVYDLAGFSLGIDERIKMLPPVDCICLADVILGLSSSGVHSKGFSLVHNILKISGHSYKDVAPFSATGKTFAEELLVPTRIYVHELQSLLVEGLVKVLAYIIGSGFKESIPRVLPAGVAAFLDLTELHIPPIFGAGGTALGTVVKKSDPLGQCVIEQGFEETLRLSTLSCSLPKERIAVLISGSDSNLQALIDATRNSIFGIRGEIVLVVSYKAGVFWLMRATKAGIRSKITLYKDYGRGSCSMQPFGRCWSRSTSSCGVSINIHPALSRHKCIHAQLQALEAGDVESGCTVHFVDEGIDTGATILQERVPILRTTTEEALIERIHQAEHKAYPKALRLVANGMATLGLDGSLKCMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PXT4</accession>
    <name>A0A182PXT4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4781 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PXT4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014160-RA">
        <property type="protein sequence ID" value="AEPI014160-PA"/>
        <property type="gene ID" value="AEPI014160"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014160"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131896" description="DUF4781 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014160-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31671" checksum="CB9E988B84F57CA8" modified="2016-09-07" version="1">MLTVSVLALAVLLSEQGPRAFCGPAGNDSTASQQHWSRLYGPAAAIGLSEEDRFYTLDYSQSTQRPRSRASKTSSGWRREPRFISFETKDNSIEVEIDFAIPFLSIPVQKSVNGVMSSVLKGTPLLNVNLGAVAVAGALTVGGALVGAVARTFSNSSTTSTLPWSSLLSLGGPRRAEISQRSAEDGNVLWTLLDALDRTMEDYDIDTVACAQRTICWYVKEANVAVAEGRATSIDTVVEGLSRADWLGGFITGTSIEQAIQAGRERKTSCEKLFPDCAISSFVEHIVRMARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYT0</accession>
    <name>A0A182PYT0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PYT0"/>
    <dbReference type="STRING" id="199890.A0A182PYT0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014472-RA">
        <property type="protein sequence ID" value="AEPI014472-PA"/>
        <property type="gene ID" value="AEPI014472"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014472"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031874">
        <property type="entry name" value="Cuticle_Acp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12336">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12336:SF0">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15955">
        <property type="entry name" value="Cuticle_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131997" description="Cuticle protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014472-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13001" checksum="ED43F1E61EEB7D48" modified="2016-09-07" version="1">MKCIAAVVMMAVAVAVQGSSVSYWGNGAALQHLAPVPVGSWVQDNSYARIVAPWNYAYQAPVATVAAAPVAYVEPYTYQPAVAVVAQKEARYLAANRGAVHEAPLPGHTVNQQSLNLEPAPGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PM02</accession>
    <name>A0A240PM02_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine rich immune protein (Short)</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A240PM02"/>
    <dbReference type="STRING" id="199890.A0A240PM02"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015255-RA">
        <property type="protein sequence ID" value="AEPI015255-PA"/>
        <property type="gene ID" value="AEPI015255"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015255"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF211">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012127911" description="Leucine rich immune protein (Short)" evidence="4">
        <location>
            <begin position="24"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="324"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015255-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42391" checksum="32487FAAA7529EA1" modified="2017-10-25" version="1">MSGNSLLCVFLSMLLLAINPCSSTAVKKTIECSRVQGNSTCFIEGVSFQSTADEYLAAFPVSSHLIIESSEILHFAPHLFDALAETAFLTLKGSLIPAVTFRSDQLHSLRIDNTGLREFAVAPQENRNLNTLIINGNPLSAIPPTVRHLAALSILDLSNNQLEYVQLGWFQTLDNLLVLDLSANRIARIDVPPSLRLARLKNFWANHNQLRQLAYFPHFAPSLRRVRLVENRWSCEWVAQVRASIWTSQIQVYGAEYVCPDVVDGGLCCYEGQWFNEMDANVQQVGRGYSERGRLLEAFPRAESLLATVDSGENDRESRLGQSCDVLEQKYRRLVEEKELLERRFVNTVRELERTVRRLTAELSEAQDKVRWQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FGN0</accession>
    <name>A0A9I3FGN0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A9I3FGN0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015525-RA">
        <property type="protein sequence ID" value="AEPI015525-PA"/>
        <property type="gene ID" value="AEPI015525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF61">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="738"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015525-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="806" mass="92808" checksum="8427C9307CD091EB" modified="2023-06-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P085</accession>
    <name>A0A182P085_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoporin Nup133/Nup155-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P085"/>
    <dbReference type="STRING" id="199890.A0A182P085"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000317-RA">
        <property type="protein sequence ID" value="AEPI000317-PA"/>
        <property type="gene ID" value="AEPI000317"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000317"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000238">
        <property type="entry name" value="Nuclear pore complex protein Nup133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1380:FF:000002">
        <property type="entry name" value="Nup133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.700:FF:000002">
        <property type="entry name" value="Nup133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="6">
        <location>
            <begin position="67"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000317-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1200" mass="136439" checksum="B896FC8A2BA703B0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P094</accession>
    <name>A0A182P094_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family. PHYHD1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P094"/>
    <dbReference type="STRING" id="199890.A0A182P094"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000326-RA">
        <property type="protein sequence ID" value="AEPI000326-PA"/>
        <property type="gene ID" value="AEPI000326"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000326"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000326-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32961" checksum="08C24112703470D4" modified="2016-09-07" version="1">LSLFFASFALQIRDDGFAVIDDFLTPDEVRELLQVGQNLHQEAPKEERKVFSAKADSKSAQSREQYFLESADKVRYFFEEGAVGENGELVVDPAIALNKVGHALHTESPAFEKVTFSNRVKEVCWQLGFRRPAVAQSMYIFKNPGIGGEVKSHQDATYLYTEPSTTIGFWIPLEDATLQNGCLHFIKGSHKSGVHRRWVRNPDKNADELLVYDRPAPLYPQSNFVAVPVKAGSCVLIHSQVVHRSDANKSDRSRHAYTFHVIETEDCEYSKENWLQPAEDRPFPVLYERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0V9</accession>
    <name>A0A182P0V9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0V9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000541-RA">
        <property type="protein sequence ID" value="AEPI000541-PA"/>
        <property type="gene ID" value="AEPI000541"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000541"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000541-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20929" checksum="13CE0564BF13971E" modified="2016-09-07" version="1">MTKTFANLTPGELALAAGKPAPPEPPSHTLDVPVLGEPERPSPWQALFGATRTVMRDRLRMAQLMLTIGALALIRPQYNDAMQWTTLVVLCHTFVLSGALLWDRHCGGAIVQRHLPLLDWRLHELQYTGAATLALYALSYGVMFAHKGYGGSVACNWVSSVLTLLTALLYGGETWIQLRNQYDGRTGLGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P130</accession>
    <name>A0A182P130_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P130"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000612-RA">
        <property type="protein sequence ID" value="AEPI000612-PA"/>
        <property type="gene ID" value="AEPI000612"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000612"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04443">
        <property type="entry name" value="DEP_GPR155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037368">
        <property type="entry name" value="GPR155_DEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051832">
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        <property type="entry name" value="DEP DOMAIN PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR155"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000612-PA"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1110" mass="122023" checksum="FCCF37D4E37BB641" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P156</accession>
    <name>A0A182P156_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P156"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000638-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="265" mass="28917" checksum="C472C72BE036DAF4" modified="2016-09-07" version="1">MAWCLYVAGRSVELDVVDSFLVRGIGHLGNWESNLGDSRQSYLGDGGVHLSWSRSLVVLLHGLGLIVHRLRSEHLGNSWSSIYLSDRGNNLGNWSKSLHHLVALNRLAADDGVESVVVIGGVVNNAAVTISIDQGVLSLDDISVAFLLLALNVSSVVIMHIVRELVLGRSIGIFDVLHGLDQSWLDSFNQSGLNSFNQSGLLVNYLLGLWLVVIFGLVMVLRLLVLLVVLGAGHSDKSEQSDVLKWTNNNEKCVKTEHVVFTVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P198</accession>
    <name>A0A182P198_9DIPT</name>
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        <recommendedName>
            <fullName evidence="12">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P198"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000680-RA">
        <property type="protein sequence ID" value="AEPI000680-PA"/>
        <property type="gene ID" value="AEPI000680"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000680"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="600"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="601"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000680-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="705" mass="80657" checksum="CFC5663499E7B56C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1U9</accession>
    <name>A0A182P1U9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-1,4-glucuronyltransferase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">I-beta-1,3-N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Poly-N-acetyllactosamine extension enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>3-O-[beta-D-Xyl-(1-&gt;4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1-&gt;3)-beta-D-Xyl-(1-&gt;4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46860"/>
            <dbReference type="Rhea" id="RHEA-COMP:15023"/>
            <dbReference type="Rhea" id="RHEA-COMP:17482"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:142405"/>
            <dbReference type="ChEBI" id="CHEBI:177336"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 49 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1U9"/>
    <dbReference type="STRING" id="199890.A0A182P1U9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000883-RA">
        <property type="protein sequence ID" value="AEPI000883-PA"/>
        <property type="gene ID" value="AEPI000883"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000883"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043189">
        <property type="entry name" value="B4GAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46420">
        <property type="entry name" value="BETA-1,4-GLUCURONYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46420:SF1">
        <property type="entry name" value="BETA-1,4-GLUCURONYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000883-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="113" mass="12956" checksum="4B090497DB26C7BB" modified="2016-09-07" version="1">MTMSDVIYRVYEMFVAGYQFQVLTPLFTVHWGLQNKKSRPAWRERQNNVNRKYFEVFKREVFARYHKDPLRMLLPKKSPKQQQQQQQHAPGAIAPGVAGAIGAVGVGAAGEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P297</accession>
    <name>A0A182P297_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LAMTOR3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P297"/>
    <dbReference type="STRING" id="199890.A0A182P297"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001031-RA">
        <property type="protein sequence ID" value="AEPI001031-PA"/>
        <property type="gene ID" value="AEPI001031"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001031"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000003">
        <property type="entry name" value="ragulator complex protein LAMTOR3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015019">
        <property type="entry name" value="LAMTOR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13378:SF1">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13378">
        <property type="entry name" value="REGULATOR COMPLEX PROTEIN LAMTOR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08923">
        <property type="entry name" value="MAPKK1_Int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01278">
        <property type="entry name" value="MAPKK1_Int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001031-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13930" checksum="348CDF32E754E974" modified="2016-09-07" version="1">MTDDVKRFFHNIRKRVAGLNCIIITDRDGVPLMKFGDDKSLGMIMKPSFHTTFTMATEQSNKLGLGRNRNIISVYTGYQVVQMNKLPLLVTFIGTESCNIGHILALDQQIELVLDEVKVAVTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2M9</accession>
    <name>A0A182P2M9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2M9"/>
    <dbReference type="STRING" id="199890.A0A182P2M9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001163-RA">
        <property type="protein sequence ID" value="AEPI001163-PA"/>
        <property type="gene ID" value="AEPI001163"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001163"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089720">
        <property type="term" value="F:caspase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043027">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022416">
        <property type="term" value="P:chaeta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16713">
        <property type="entry name" value="RING-HC_BIRC2_3_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000184">
        <property type="entry name" value="Baculoviral IAP repeat containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001163-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="200" mass="22285" checksum="A625434F4B4443C3" modified="2019-01-16" version="2">MASNSSSGQRGGIQQVEMPYMPDYASLDTRIRSFRNWNYGHVQDPTRLAEAGLYYTGPEDEVRCFHCDGGLRDWLVTDDPWHEHARSFAGCNFLQLVLGETYISEVLRNGNVGIADEGCTTSSATVSQTSSSSTTSIERLREENNRLKEERECKICLTREVGVVFCPCGHLVSCVQCAPAIYNCPVCRALITGRIRTFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P530</accession>
    <name>A0A182P530_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P530"/>
    <dbReference type="STRING" id="199890.A0A182P530"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002017-RA">
        <property type="protein sequence ID" value="AEPI002017-PA"/>
        <property type="gene ID" value="AEPI002017"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002017"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130808" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002017-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="28374" checksum="7A5B30ECDC2A8099" modified="2016-09-07" version="1">MIRPILPILAYMSVLSSTYSLHMARDAYIKPPPPPPPASQLLDDLDDMSELLAENGVDLMRPMMGTVHQKAHAGTTGGGGVGGGGGGGSGSIISIGSAGGGGSVALGTINHMTSNELPELSPPPAHLPSGLRHGPIGPLVGQPPRGLQELFGVQTNFDIRAAQQQLSHGPNDRASASFDQSSASGMDDRDDDNGGGGEDSNRAGGQDGDQGNGNLQRSAASNKRASPTGGRNKMMADSAQDGGGSSSGLPSIPHGIANQMMLRSTRGQRQYDVPQIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P588</accession>
    <name>A0A182P588_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P588"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002076-RA">
        <property type="protein sequence ID" value="AEPI002076-PA"/>
        <property type="gene ID" value="AEPI002076"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002076"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130980" evidence="1">
        <location>
            <begin position="25"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002076-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="416" mass="47996" checksum="AB090E54D86213E7" modified="2016-09-07" version="1">MKSVGWLVLTVAVVFCVGVRWCDGRPQRDGYPRETCCNNCAACRHNFDVEAPKDPGCRKLHNFHYDVEKFTDCQKETYDRLDAAVEDLPDRGCRKTYHYHYDVDKPCCCEEDNYDTYDFEVLEPKSKKKCPKVKLAAHADHPTRDCQCDCRNRRYVMRDGIQFNSSVLEPLADDSDRNSIPRLKRSVLVPLRGDFSVDDPSAPIPVQFFYQVPNKPQARRNFRARRPILRHLPNRLRSKRKELEQNGEEGGFWCRCMPWEQVGQEKPDDIVGAPRKAAGRRGEAESAVYIGDSSNPVTYEQIKKYLDALPREEYSPTTNDVIGNLTILFYDIYQQKHKKNFTLPLKYGTRTVIDRGDGLQTYDIAPIEGEYRPPKLNRIASKGVGLIGRKIDRKTDANVDLRRNRIRNRSRVGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P624</accession>
    <name>A0A182P624_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P624"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002367-RA">
        <property type="protein sequence ID" value="AEPI002367-PA"/>
        <property type="gene ID" value="AEPI002367"/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P6H4"/>
    <dbReference type="STRING" id="199890.A0A182P6H4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002522-RA">
        <property type="protein sequence ID" value="AEPI002522-PA"/>
        <property type="gene ID" value="AEPI002522"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002522"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF43">
        <property type="entry name" value="GEO07291P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130867" evidence="6">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002522-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="131" mass="14780" checksum="8344093FAEA3979A" modified="2016-09-07" version="1">MKSFFVVASFVLLVASVNAFTLRQQKMVSIFALECMAETGIGAESLTKLRDGDLTANDRTAKCFMKCFFEKENFMDAEGKLQLEAIATALEKDYERAAIDEMLVKCGVQKEDACETAFNAYECYHDHYQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7I6</accession>
    <name>A0A182P7I6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="EnsemblMetazoa" id="AEPI002888-RA">
        <property type="protein sequence ID" value="AEPI002888-PA"/>
        <property type="gene ID" value="AEPI002888"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002888"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002888-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="15" mass="1719" checksum="542E1BEB8182E33E" modified="2016-09-07" version="1">MHGNPSFLRVILTMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7J0</accession>
    <name>A0A182P7J0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7J0"/>
    <dbReference type="STRING" id="199890.A0A182P7J0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002893-RA">
        <property type="protein sequence ID" value="AEPI002893-PA"/>
        <property type="gene ID" value="AEPI002893"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002893"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF216">
        <property type="entry name" value="ZINC FINGER PROTEIN 420-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="526"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="673"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002893-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="711" mass="81634" checksum="F85FA13BC1848277" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7K4</accession>
    <name>A0A182P7K4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7K4"/>
    <dbReference type="STRING" id="199890.A0A182P7K4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002907-RA">
        <property type="protein sequence ID" value="AEPI002907-PA"/>
        <property type="gene ID" value="AEPI002907"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002907"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="224"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002907-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="379" mass="42628" checksum="C272456A67E1C65E" modified="2016-09-07" version="1">MGGTRNKKVKLPVSNNKQKKAVSKWEEEQGNSPVATKKQQKQAPKSAKTSNDNAPSRKPIVFVSPRPADEPSSDEAEEMEGTEEEPQTVPLKLPVLEPVPTDIPDPHLEPNKIKLLKPLIGYIYNGDQMSLKLSFEQAGLLLTPDYNEETRVFRFKVDMKEICRAEGEKNEAHSIAREKLVQIVRYYCYTVKRVKEYHTRRKIFYTRPPKMALQAQKDQKKISEQNVGFQMLQKQGWNPGTALGMSMEGIIEPIVAKKRKGKSGLGVEDAVAPDGSQEKVKIPIEAFYLLLKQYAGVNALYDIVFSTQFSKHQVAKLKSFALSLKLFPQMIGTNKKKLVVSRPLTIKEIKEGVMKGHSDLCAKYIVIPPAAGIPKEDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7L8</accession>
    <name>A0A182P7L8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P7L8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002921-RA">
        <property type="protein sequence ID" value="AEPI002921-PA"/>
        <property type="gene ID" value="AEPI002921"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002921"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001702">
        <property type="entry name" value="AGAP000009-PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000664">
        <property type="entry name" value="Lethal2_giant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="15">
        <location>
            <begin position="1241"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="640"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="735"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="818"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1007"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="823"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="887"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1007"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1020"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002921-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1399" mass="153144" checksum="ADA3A1369941924A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P822</accession>
    <name>A0A182P822_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dystroglycan 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Dystroglycan</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dystrophin-associated glycoprotein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="DAG1_C"/>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030398">
        <property type="entry name" value="SEA_DG_dom"/>
    </dbReference>
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        <property type="entry name" value="DYSTROGLYCAN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21559">
        <property type="entry name" value="DYSTROGLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51699">
        <property type="entry name" value="SEA_DG"/>
        <property type="match status" value="2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="836"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S72" evidence="16">
        <location>
            <begin position="464"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S72" evidence="16">
        <location>
            <begin position="695"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="131"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="293"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="900"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
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            <end position="244"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023567"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024991"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026224"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030092"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031034"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003075-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="967" mass="107624" checksum="97E266123900B729" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P879</accession>
    <name>A0A182P879_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The selectivity filter, in which calcium ions are arranged in single file, is composed of two acidic rings separated by one helical turn along the central axis of the channel pore.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCU (TC 1.A.77) family.</text>
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        <property type="gene ID" value="AEPI003132"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:uniporter activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
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        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 15" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="16">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003132-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="244" mass="28044" checksum="554A46490245CD2E" modified="2016-09-07" version="1">MPAEPAQLHLNDRQYYVKPPKREKITSEEITRLGDVQALVAQLYEALHVGEHQIQKERELNGKLEQLNEKLGPLEAKKNELDQKAARKTNALTWVGLGLMSVQFGVLARLTWWEYSWDIMEPVTYFVTYGTAMAAYAYFVLTKQEYLLPDVKDRQHLITLHKAAKKAGVNLAEYNDIKRQIAEIEHDLRRLRDPLYMHLPAPPPKTKTFSASEIAFAKKQQHKASLEMQQQAPMVDGSVLKTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8G5</accession>
    <name>A0A182P8G5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CIDE-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P8G5"/>
    <dbReference type="STRING" id="199890.A0A182P8G5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003218-RA">
        <property type="protein sequence ID" value="AEPI003218-PA"/>
        <property type="gene ID" value="AEPI003218"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003218"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01615">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003508">
        <property type="entry name" value="CIDE-N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12306">
        <property type="entry name" value="CELL DEATH ACTIVATOR CIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12306:SF15">
        <property type="entry name" value="DNAATION FACTOR-RELATED PROTEIN 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02017">
        <property type="entry name" value="CIDE-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00266">
        <property type="entry name" value="CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51135">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIDE-N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003218-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="299" mass="32558" checksum="0792C77CB3170CF4" modified="2016-09-07" version="1">MTPAISATIIKDVTRAIKKAVVAGTLEEVRTKAAEKFGRTDLPNIHLDSDGTEVDDEDYFQTLEPNAELIAVFSGEQWIDPTHYVTITTRRDSADITDSPEVERIHLKKLVAQMKTNLCNVSVLSEPDLELLSNMDPNSVADITGKDFIEQLKEASGRILHEKRKAADAIELLKLISKQPIVRNEAEDSSNCEYDDDDANTHQLRSFLTATVRPAPIVSQPQRTDTTAAAAEESSSSPSTTIISIPGTVGSYSDGKHNITVHLQPTVGSNIADSAGEDTLDKCQAKPTDCNSEHHGKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8G8</accession>
    <name>A0A182P8G8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PBZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8G8"/>
    <dbReference type="STRING" id="199890.A0A182P8G8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003221-RA">
        <property type="protein sequence ID" value="AEPI003221-PA"/>
        <property type="gene ID" value="AEPI003221"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003221"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09193">
        <property type="entry name" value="PLDc_mTdp1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000039">
        <property type="entry name" value="Probable tyrosyl-DNA phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000051">
        <property type="entry name" value="Probable tyrosyl-DNA phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBZ-type" evidence="13">
        <location>
            <begin position="3"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="73"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003221-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1097" mass="123825" checksum="E47E77C33FA413ED" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8K7</accession>
    <name>A0A182P8K7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P8K7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003260-RA">
        <property type="protein sequence ID" value="AEPI003260-PA"/>
        <property type="gene ID" value="AEPI003260"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003260"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.100:FF:000001">
        <property type="entry name" value="Enhancer of mRNA-decapping protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.100">
        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049404">
        <property type="entry name" value="EDC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044938">
        <property type="entry name" value="EDC4_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032401">
        <property type="entry name" value="EDC4_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21289">
        <property type="entry name" value="EDC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16529">
        <property type="entry name" value="Ge1_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Enhancer of mRNA-decapping protein 4 WD40 repeat region" evidence="9">
        <location>
            <begin position="48"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Enhancer of mRNA-decapping protein 4 C-terminal" evidence="10">
        <location>
            <begin position="1438"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="865"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1037"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1126"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003260-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1568" mass="170055" checksum="47A58D5E47EA87D8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8L1</accession>
    <name>A0A182P8L1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P8L1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003264-RA">
        <property type="protein sequence ID" value="AEPI003264-PA"/>
        <property type="gene ID" value="AEPI003264"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003264"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21385:SF0">
        <property type="entry name" value="RE51073P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21385">
        <property type="entry name" value="ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003264-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="672" mass="74030" checksum="F2E83F9C294E8284" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9J0</accession>
    <name>A0A182P9J0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase 16 kDa proteolipid subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">V-type proton ATPase 21 kDa proteolipid subunit c''</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Vacuolar proton pump 16 kDa proteolipid subunit c</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9J0"/>
    <dbReference type="STRING" id="199890.A0A182P9J0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003595-RA">
        <property type="protein sequence ID" value="AEPI003595-PA"/>
        <property type="gene ID" value="AEPI003595"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003595"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="56"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="145"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003595-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="214" mass="22505" checksum="3E18CCF41D06AAC3" modified="2016-09-07" version="1">MQTKIKMRYTLGYIFSTSFVSVATVLILYHVLTGKGERVSVGWFLEETSPYMWATLGIGFAVALSVVGAAMGIHTTGVSIVGGGVKAPRIKTKNLISVIFCEAVAIYGLITAIVLSGMLDSFKWSVVAGNENIRNNNWMSGYVMFGAGLAVGLVNLFCGIAVGIVGSGAALADAANSALFVKILIVEIFGSAIGLFGLIVGIYMTSKVKMGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9M2</accession>
    <name>A0A182P9M2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9M2"/>
    <dbReference type="STRING" id="199890.A0A182P9M2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003627-RA">
        <property type="protein sequence ID" value="AEPI003627-PA"/>
        <property type="gene ID" value="AEPI003627"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003627"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF327">
        <property type="entry name" value="PROTEIN CBG16280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003627-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="355" mass="37553" checksum="777A858DB7A2FAF2" modified="2016-09-07" version="1">MINHHTMASLGHPHYGFALGNGMDIPPAADFAPQPHHSPSSPTDHLGLKRGLTFPASSLAGLQGHGGMHGAASAAAHHHHHHSSVGQNGGAGGPGTGGMGNGQTSPGQEGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGSEWKLLTEAQKRPFIDEAKRLRATHMKEHPDYKYRPRRKPKNPLASAANGLGALGAMQQGGKAGSLGSSYPFPQLPPYFAPAHPLQQLEQHYPVPYFGSFDPLALQKLHQSQQNVQAGHSPVGGGIGDTGKQSAGQQLPPTSLSSFYSNIYAGISASAAAAPLYAAHSSSLYNTSSTSSASPGSSPSASQSTLPDLENAMRRPVQVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9S7</accession>
    <name>A0A182P9S7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NF-kappa-B-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9S7"/>
    <dbReference type="STRING" id="199890.A0A182P9S7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003681-RA">
        <property type="protein sequence ID" value="AEPI003681-PA"/>
        <property type="gene ID" value="AEPI003681"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003681"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="194"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003681-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="301" mass="33271" checksum="74242F34BB07E025" modified="2016-09-07" version="1">MHDMYESHDSQRNVDRSFRRSNRDPVDDDFMQSRRLQREIIGTEGAPEAWGDSPSEGNSSDEELAPSKGGTAKHKKGKAKGKEKKKTSKHKKDKKKKKSSKKSKKSKSSKKKKRKAKKVESSSSSDPSSSSDSSSGAEEEEEWVEKSEAIAHAVGRGGEGSAAQATGSSQARSVEEDGDNVVGPVKTSGNLSQKDFGRALLPGEGAAMAAYVTEGKRIPRRGEIGLTSDEIANFEQVGYVMSGSRHRRMEAVRIRKENQIYSADEKRALAMFSKEERQKRENKILTQFKEMISAKLSENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9V1</accession>
    <name>A0A182P9V1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P9V1"/>
    <dbReference type="STRING" id="199890.A0A182P9V1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003705-RA">
        <property type="protein sequence ID" value="AEPI003705-PA"/>
        <property type="gene ID" value="AEPI003705"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003705"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131007" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="80"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003705-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="131" mass="14426" checksum="3E2AEB69098B0B78" modified="2016-09-07" version="1">MQASTSTVWIAVLVLAVSVATAEPTCRPTGQYLVSNPRDCQSYFYCFQGIAYYGACQPGYRFDAARQSCLQSTVAECFECPRMGILSLPHPTSCQMFVLCFEGVANERSCPDGLLFNRQLHQCDLSANVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9V3</accession>
    <name>A0A182P9V3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182P9V3"/>
    <dbReference type="STRING" id="199890.A0A182P9V3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003707-RA">
        <property type="protein sequence ID" value="AEPI003707-PA"/>
        <property type="gene ID" value="AEPI003707"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003707"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000598">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF81">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003707-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="305" mass="34696" checksum="78DA6712DD0C70E4" modified="2016-09-07" version="1">MTSEKRMSCVKEFYKDATILLTGGTGFIGKVLLEKLLRCFDVKTVFLLIRQKRNKTADERLHEVFEDVIFDTIKSSPHNGKALFAKVIPIGVNFQSEEVISSASYQRLLTAHVEIVFNVMASVKFNEDIETAIDTNVLSSRKLFQLAQQLPHIRSIVHVSTFYSNCHRTHIEERIYEDLPFGGFDNILALFRHLTPEEKDRLKPIILGPMPNSYTFSKRCAEVMVQQQFNQLPIAIFRPPIVSSAYREPTPGWVNNFNGPAGMVVPVIRGQVYWVYGVDDATVHMVPVDYCVNALLTVAWDNGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA21</accession>
    <name>A0A182PA21_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Exosome component 9</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PA21"/>
    <dbReference type="STRING" id="199890.A0A182PA21"/>
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        <property type="protein sequence ID" value="AEPI003775-PA"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI003775"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:nuclear mRNA surveillance"/>
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        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:rRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
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        <property type="term" value="P:U4 snRNA 3'-end processing"/>
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        <property type="term" value="P:U5 snRNA 3'-end processing"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exosome complex component RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
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        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
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        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
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        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
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        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
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        <location>
            <begin position="31"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="13">
        <location>
            <begin position="189"/>
            <end position="246"/>
        </location>
    </feature>
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            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="390"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003775-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="437" mass="48732" checksum="0D2523CD4A5758D0" modified="2016-09-07" version="1">MKERILTNNEKSFVQKAILESIRIDGRTQDEFRKLRICFGSEWGLVHVILGETRALARITCEVVEPKATRPNEGMLFVNVELGPMAAPHFDGGRQSDECVQLNRILERALKDSGCVDLESLCLVSEEKVWKLRVDVTVLNHEGNAIDCCSIAALTALAHFKRPDITVDGENVIVHTLEEKDPLKVTLFHYPICVSYAIFNQGKIAIADPTYLEERVAEANMVFGINSYGELCGLHLGGTTLTSSELLLRTSMKASKRARLVVEKIKAAIQKDADDRAKGVSVGFSEGIERNETTVHAQDRMQVRLKRFKLKIDGQERLDSDAGEEEEEEEEKMDATVIESSADLVNPSDEPMAVDDTIVEEVGETAAVMIPKSKDSTNQWLTEEQLRAVKERTGKKRSKASLKHKKKSLLSQSRTNDEDVLGDSDEEETVTLTSNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAV5</accession>
    <name>A0A182PAV5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fuseless</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Fuseless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35270">
        <property type="entry name" value="FUSELESS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35270:SF2">
        <property type="entry name" value="FUSELESS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fuseless"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="144"/>
            <end position="166"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004060-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="97144" checksum="D79C03B757E09018" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAX9</accession>
    <name>A0A182PAX9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAX9"/>
    <dbReference type="STRING" id="199890.A0A182PAX9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004084-RA">
        <property type="protein sequence ID" value="AEPI004084-PA"/>
        <property type="gene ID" value="AEPI004084"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004084"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004084-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15005" checksum="A40AF5E0499B87D2" modified="2016-09-07" version="1">MSHSIRRLFADCLAATAATFVLVFVLEECARRELTLYVLFAKRERLGRDDDSFASERDAAPADDHVTSFVFNAHQSLNLAAQRERLPIRQYRDQLLYCLEHYQTLVLVGETGSGKSTQVPQVRAKSTLPFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB42</accession>
    <name>A0A182PB42_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PB42"/>
    <dbReference type="STRING" id="199890.A0A182PB42"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004147-RA">
        <property type="protein sequence ID" value="AEPI004147-PA"/>
        <property type="gene ID" value="AEPI004147"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004147"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004147-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="296" mass="31067" checksum="6597BCF19DE12E47" modified="2016-09-07" version="1">MSGPPNINSNQLPSSSSGGGVGGSGSGRGWLRTPPPTYFRSPSPWVPPGSAPPRQSSPVTAPRPVDGSSAAGPPRGPSEFVYQHPSSGAFGGGGAGYPPATPQQYATGERHAIRAATATPGIGAPAQEYHQFQRPIPSAMTPTHFAGPSTHHYRPVSPAAVAPQPYPQFSSTMSPVSSLHRSMTPHSVGSVGYGPMDYQHPMQQQPQQVRPGSTQSSVYGGVTYHYGPAAGPSHPSGQSQYVIYDYGGEMGPSTAEIIAAQSQDYVDEKLAEYQATIMLLQGEFFSLSDISYWKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB71</accession>
    <name>A0A182PB71_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PB71"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004176-RA">
        <property type="protein sequence ID" value="AEPI004176-PA"/>
        <property type="gene ID" value="AEPI004176"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004176"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004176-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="275" mass="30815" checksum="18A1F5E933A0889E" modified="2016-09-07" version="1">MTGGKEINKKQQSMEIRSNYINVPLLAELIERKCRLWAEASFPTPAQGLQRETLSIIESLRLIFRNRAEFVQLTLLRVKSDRHARSLLAPVYEAFLGPPGPATASASTTTTTGLTIYRSNDVETYGRLLLCYARWKSLYWAAEEADATDPVEWADIDAVALAQLPYDFPRAICPRDALLRRIFPAYVTAKCAAGVAPSDRKRNNATTRILLGTLPKRADLQELCLKFYQAYRCGADATQLEDEIPPQGQEAADTPLSGPSTSVTLEHHRQTRYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBQ1</accession>
    <name>A0A182PBQ1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase complex subunit SAP130 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP130 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PBQ1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004356-RA">
        <property type="protein sequence ID" value="AEPI004356-PA"/>
        <property type="gene ID" value="AEPI004356"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004356"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024137">
        <property type="entry name" value="His_deAcase_cplx_SAP130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031963">
        <property type="entry name" value="SAP130_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13497">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13497:SF3">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16014">
        <property type="entry name" value="SAP130_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP130 C-terminal" evidence="9">
        <location>
            <begin position="1461"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1143"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1175"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1219"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1282"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1316"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1546"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="471"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1068"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1182"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1224"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1327"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1382"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1415"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1548"/>
            <end position="1559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004356-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1624" mass="162212" checksum="5A85009649DD69F7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBR9</accession>
    <name>A0A182PBR9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBR9"/>
    <dbReference type="STRING" id="199890.A0A182PBR9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004375-RA">
        <property type="protein sequence ID" value="AEPI004375-PA"/>
        <property type="gene ID" value="AEPI004375"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004375"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004375-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="120" mass="13070" checksum="A48D167B52412EBE" modified="2016-09-07" version="1">MQVEPSLLAVSCIASATRGLNVSTKLAVGYDLCRMTMHDLGKIDLMVKIIEDIVAREIADKQCQQQQAAQQQAQLAAASSSCKEQYQQAPQKLANATNSTGGPPQQQQPETPTDVQFIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCK5</accession>
    <name>A0A182PCK5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ras GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCK5"/>
    <dbReference type="STRING" id="199890.A0A182PCK5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004660-RA">
        <property type="protein sequence ID" value="AEPI004660-PA"/>
        <property type="gene ID" value="AEPI004660"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004660"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08400">
        <property type="entry name" value="C2_Ras_p21A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13260">
        <property type="entry name" value="PH_RASA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10354">
        <property type="entry name" value="SH2_Cterm_RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10353">
        <property type="entry name" value="SH2_Nterm_RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11788">
        <property type="entry name" value="SH3_RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000402">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035842">
        <property type="entry name" value="RasGAP_C_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035841">
        <property type="entry name" value="RasGAP_N_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035652">
        <property type="entry name" value="RasGAP_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF146">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="73"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="170"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="242"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="369"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="473"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="11">
        <location>
            <begin position="643"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004660-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="948" mass="107075" checksum="F2C393BD10CFC4A5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD31</accession>
    <name>A0A182PD31_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PD31"/>
    <dbReference type="STRING" id="199890.A0A182PD31"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004836-RA">
        <property type="protein sequence ID" value="AEPI004836-PA"/>
        <property type="gene ID" value="AEPI004836"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004836"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF43">
        <property type="entry name" value="PAIRED BOX POX-NEURO PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004836-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="86" mass="9600" checksum="771381021C8A686A" modified="2016-09-07" version="1">MQRPSSGSGCTEGISQALQVATPTVVKKILRFKQENPGMFAWEIRDQLLSQRICDPNTIPSVSSVNRILRNGGMWTDDMTSNDKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD70</accession>
    <name>A0A182PD70_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-C</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the Cdk8 module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PD70"/>
    <dbReference type="STRING" id="199890.A0A182PD70"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004875-RA">
        <property type="protein sequence ID" value="AEPI004875-PA"/>
        <property type="gene ID" value="AEPI004875"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004875"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20514">
        <property type="entry name" value="CYCLIN_CCNC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000015">
        <property type="entry name" value="Putative cyclin-c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 11" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="161"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004875-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="266" mass="31458" checksum="FC97F8583C25773E" modified="2016-09-07" version="1">MAGNFWQSSHHQQWILDKQDLIRERQHDLKTLTEEEYQKIFMFFANIIQVLGEQLKLRQQVIATATVYFKRFYARNSLKCIDPLLLAPTCILLSSKVEEFGVISNSRLITTCQTVIKNKFSYAYQQEFPYRTNHILECEFYLLENLDCCLIVYQPYRPLLQLMQDIGQEEQLLTLTWRLINDSLRTDVSLLYPPYQIAIGCLQIACVILQKELKSWFAELNVDMDKVQEIARAIVNLFELWKGYDEKKEIQALLEKMPKPKPHPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE01</accession>
    <name>A0A182PE01_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PRKR-like endoplasmic reticulum kinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PE01"/>
    <dbReference type="STRING" id="199890.A0A182PE01"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005156-RA">
        <property type="protein sequence ID" value="AEPI005156-PA"/>
        <property type="gene ID" value="AEPI005156"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005156"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09768">
        <property type="entry name" value="Luminal_EIF2AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000193">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF91">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="7" id="KW-0834">Unfolded protein response</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131197" description="PRKR-like endoplasmic reticulum kinase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="591"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="763"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="840"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1022"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="878"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1037"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1051"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005156-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1075" mass="118305" checksum="FF8109C73E8D4AF8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE77</accession>
    <name>A0A182PE77_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NTPase_I-T domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRRC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PE77"/>
    <dbReference type="STRING" id="199890.A0A182PE77"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005232-RA">
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        <property type="gene ID" value="AEPI005232"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005232"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000017">
        <property type="entry name" value="Protein PRRC1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026533">
        <property type="entry name" value="NTPase/PRRC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026534">
        <property type="entry name" value="PRRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23276">
        <property type="entry name" value="PROTEIN PRRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23276:SF2">
        <property type="entry name" value="PROTEIN PRRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01931">
        <property type="entry name" value="NTPase_I-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-canonical purine NTP phosphatase/PRRC1" evidence="5">
        <location>
            <begin position="184"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005232-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="328" mass="34679" checksum="B1370369C087A607" modified="2016-09-07" version="1">MSDLKKKTGNILSNVSPPSELPSFITANVAPPPAVTEPVPPSVTKPMATVDDAAKKDETEPFIPTTFSPAIPAIKDTSQFSAEQAMAAAGVHPVEPAPEPVGRDFANMILNPEPVAAALSPITQGGSALFGWMKGAVSGSGILQKVAEKAKNSVDTIVTTLDPQMKEYINSGGDTEVIVASDKDDKVRPVREAFQTVFGKATIIGLAAQAVGIAAQPVGFAAGLKGAEHRINSIRAENPRVDDHLPVVAVENFIVELFPDQWFEAGAIVLFDYAKNILLKTVTQLTPIPLPVITALQADTPEDYMLKDTGFATTVGSIMARNLNFLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEA3</accession>
    <name>A0A182PEA3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
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            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Howell P."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="8">Epiroticus2</strain>
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</entry>
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            <taxon>Diptera</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
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    <reference evidence="8" key="2">
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000428">
        <property type="entry name" value="AGAP005310-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131400" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="27"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006032-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="260" mass="28351" checksum="36E880AE9B70B809" modified="2016-09-07" version="1">MNSCAGAVFLVVVLGVSIAQGSVIGRVAGGSNARRGQFPYQVAMTLKRQTVCGGVMVHERFFLTAAHCFFKGETPLPLEQLNVFYGSEKLFSNGRYNRVKSVHFHEQYENGSNKYDLAVVEVKRKFDLSSASRPVAFGEEAFGENLLATVTGYGRNTVEGNMAFRLKYAQLSSMSDAQCREAMGEDYYEGVFCLDTSDGAGFCLGDYGGPAVFEERLVGVGSYTVGNKCEAGQPDVFVDVGYFSEWVQSVLEAEPEEGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGV6</accession>
    <name>A0A182PGV6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGV6"/>
    <dbReference type="STRING" id="199890.A0A182PGV6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006165-RA">
        <property type="protein sequence ID" value="AEPI006165-PA"/>
        <property type="gene ID" value="AEPI006165"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006165"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070842">
        <property type="term" value="P:aggresome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03773">
        <property type="entry name" value="MATH_TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037299">
        <property type="entry name" value="TRIM37_MATH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053003">
        <property type="entry name" value="TRIM_RBCC_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36754">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36754:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="177"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="334"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006165-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="483" mass="57174" checksum="C9F21814FDEBC95B" modified="2016-09-07" version="1">EYDSNVITICNIRDPTTSIVLSKQYTDTVGSRWRLNVYPKGNNTNQRYLSTYVELCDGIAGRYQYTVELLHDDVTRQVKFQSEDHFRVGEIRGYQKFIRVRRLLEEGYLNQEGSILIRLSIRPANLALRCQYQEEYQTLKEEKLRTQFNTQLNQNLMRIKSLRDDNASLQALVYPEYASNIFVVRNFSALREAQEDICSDNAYDDVGCCWRLIVYANGDKEGRDEWLSVYLRLLEGIPGSYEYCVELLHNDAAKTVKMEGTQSFDIQERFGWTRFARLDWICANGFVSEEQDALYFRFSLRPPNYKAKCEYHHLLRLEARRECELLKRELIPAYSTMTYTLRNFSEMQRKDSFIYSDPLVDDLGFSWRLLIYANGHNEARDNHLSVYLILFEGVSASRFEYRVELLHPQNPTANIKMEGVNVFKLKKIWGWPQFMDHERLQEEGYLDRTTDTLEFRLSMCPPDIKLKCEYQQEFIRKLKENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH85</accession>
    <name>A0A182PH85_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Titin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PH85"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006294-RA">
        <property type="protein sequence ID" value="AEPI006294-PA"/>
        <property type="gene ID" value="AEPI006294"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006294"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001806">
        <property type="entry name" value="Blast:Twitchin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001834">
        <property type="entry name" value="Blast:Twitchin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002211">
        <property type="entry name" value="GL25248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000612">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010629">
        <property type="entry name" value="Ins_allergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF167">
        <property type="entry name" value="MYOMESIN AND MYOSIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06757">
        <property type="entry name" value="Ins_allergen_rp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="167"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="273"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="366"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="461"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="802"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="917"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="960"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="872"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1068"/>
            <end position="1081"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1146"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1211"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1261"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1309"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006294-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1404" mass="155849" checksum="3B9EF79E5B4FABC9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH91</accession>
    <name>A0A182PH91_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PH91"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006300-RA">
        <property type="protein sequence ID" value="AEPI006300-PA"/>
        <property type="gene ID" value="AEPI006300"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006300"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006300-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="567" mass="64455" checksum="4246B9360E3CB3C0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHD3</accession>
    <name>A0A182PHD3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHD3"/>
    <dbReference type="STRING" id="199890.A0A182PHD3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006342-RA">
        <property type="protein sequence ID" value="AEPI006342-PA"/>
        <property type="gene ID" value="AEPI006342"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006342"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006342-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49485" checksum="C1A478B47A37E124" modified="2016-09-07" version="1">MRKYQQLALVLLSVTCVVILLVYKSENNRLKYVLEVVNIFGRNDAASLIRIDNSTRLHSSPYDFDSPLPAWQRLGDGFYVYSSFWQKNELAAGGTVISIAVGLEHAAVNFKCQVQHGTGDIATGKLHFVRLDHPTGSIKPPNSEVFVVYKLLCKVARDFGQPTEVIFTDTAQSIKRYVPLRVLESRSVQQKMTMTACVDMTDYLELEEEFRMPSAVLQYFLHHQIVGVEDFIVYNSNALNGATSSLLYSHGIKINLLPYNFPFDLADKQQNRMLIEMDCQMRNYNAAKLTYIGAINEYLYPSSRLRVNNQFLKYAWKVSSDVSRFSLASRSVCIDKRKKIFSDNLLYDVDTQLSSPNERPFQVYKPQDYNRTAGTPDFVKTLDVDRSLVFVHRYGGKCSSKTNLHDWTVSLQPDFLQYVMDVGRELNKLIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHY3</accession>
    <name>A0A182PHY3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma-interferon inducible lysosomal thiol reductase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHY3"/>
    <dbReference type="STRING" id="199890.A0A182PHY3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006544-RA">
        <property type="protein sequence ID" value="AEPI006544-PA"/>
        <property type="gene ID" value="AEPI006544"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006544"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF69">
        <property type="entry name" value="GILT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017698433" description="Gamma-interferon inducible lysosomal thiol reductase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006544-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26817" checksum="0DD8F1AFF99EE03B" modified="2019-01-16" version="2">MMFKSFLLLGVFAVACYGQSKVPVYVYYESLCPDSARFVNEQLYPVAKAFKQNLELHLVPFGKSTYTTQGSDVMFTCHHGENECYGNKVHACAIQHIQGNSYQPNISREDLTLDYVNCLMNRAQLKDGAFPSKRCADEVKIDQWQAIVDCANSTEGSQLLKQHGDVTNKLQSPLKSVPTVAFKQTYDEELQKLSVSSFRHALCKNLSPQPVECLDLPSSASVITSFSALIAVTAALLFRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI46</accession>
    <name>A0A182PI46_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051497">
        <property type="entry name" value="Dev/Hematopoietic_TF"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    <dbReference type="PANTHER" id="PTHR45993">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993:SF6">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
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        </location>
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            <end position="288"/>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000313" key="13">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI68</accession>
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            <taxon>Diptera</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Poon T.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
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    <reference evidence="9" key="2">
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            <strain evidence="9">Epiroticus2</strain>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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</entry>
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    <accession>A0A182PJ46</accession>
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        <recommendedName>
            <fullName evidence="6">Microtubule-associated protein futsch</fullName>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
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        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <strain evidence="4">Epiroticus2</strain>
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        <property type="entry name" value="MAP1A/B/S-like_MBL"/>
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        <property type="entry name" value="ATPASE F1_V1_A1 COMPLEX ALPHA_BETA SUBUNIT NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJF5</accession>
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            <fullName evidence="7">UDP-glucose 4-epimerase</fullName>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
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        <text evidence="3">Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.</text>
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            <text>UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine</text>
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            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="5.1.3.7"/>
        </reaction>
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    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
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            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
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        </reaction>
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    <comment type="cofactor">
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            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
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    <comment type="similarity">
        <text evidence="7">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
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    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003974">
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF31">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="8">
        <location>
            <begin position="10"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007069-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="358" mass="40028" checksum="C27FE7FD60A40918" modified="2016-09-07" version="1">MTGEQKGTVLVTGGAGYIGSHTVVSLLEAGYAVVALDNFTNSVNSTKNESVALKRVEEITGKKVHFYRCDLLDKDAVERIFKAHRIDSVIHFAALKAVGESMTNPLLYYKNNMIGMINLLEVMDSLGIYKMVFSSSCTVYGEPERLPITEENPTGNVTNVYGRTKYFIEEMLKDAVRADPKWNIIALRYFNPVGAHKSGRIGEDPTKQFTNLMPYISQVAIGKKDVLTIFGNDYDTPDGTGVRDYVHVMDLASGHVAALNKLDKEHLGLKMYNLGTGKGISVMELIHTFERVNKVKIPYVIQERRAGDISSMYANATLAEQELGWKAIHSVDEMCEDFWRWQTMNPNGYKTEQANGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJN9</accession>
    <name>A0A182PJN9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Sodium/potassium-transporting ATPase subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJN9"/>
    <dbReference type="STRING" id="199890.A0A182PJN9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007153-RA">
        <property type="protein sequence ID" value="AEPI007153-PA"/>
        <property type="gene ID" value="AEPI007153"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007153"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1660:FF:000004">
        <property type="entry name" value="sodium/potassium-transporting ATPase subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF46">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007153-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="33153" checksum="A6BB967DC508A203" modified="2016-09-07" version="1">MATICVHNTAVAKIGIFYIVFYSVLAALVAVCMWVFFQTLDPRIPKWQMDQSLIGTNPGLGFRPLPSEDNVESTLIWYKGTEEKNYKMWTDALDDFLQDYRTPGQVLGRGQNIYNCDYSQPPPKGMVCEVDIKQYGPCTLENHYNYHKSAPCIFLKLNKIYGWVPDFYNDSSSLPNNMPTDLKEYIKEKEQKEQHTMNTVWVSCEGENAADIENVGQIQYYPRRGFPGYYYPYENSEGYLSPLVAVHFERPVRGIIINVECKAWAHNIKHDRHERMGTVHFELMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK49</accession>
    <name>A0A182PK49_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PK49"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007315-RA">
        <property type="protein sequence ID" value="AEPI007315-PA"/>
        <property type="gene ID" value="AEPI007315"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007315"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032224">
        <property type="term" value="P:positive regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000060">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000061">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000066">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000030">
        <property type="entry name" value="sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000034">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
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        <property type="entry name" value="SODIUM LEAK CHANNEL NALCN"/>
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    </dbReference>
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        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007315-PA"/>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1865" mass="214512" checksum="1A6FCB5FF25A6F71" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK55</accession>
    <name>A0A182PK55_9DIPT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Epiroticus2</strain>
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    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <strain evidence="1">Epiroticus2</strain>
        </source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007321-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="60" mass="6426" checksum="C5565CF229E4FFDA" modified="2016-09-07" version="1">MVVLEGGTMGTSLLGGPYAQGAPALKMMQKRYVGLHQWLSPVCATKDLKEHLPPGFGAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK77</accession>
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        <recommendedName>
            <fullName evidence="14 15">Coatomer subunit alpha</fullName>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="21">Epiroticus2</strain>
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    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with SCYL1. Interacts with JAGN1. Interacts with TMEM41B. Interacts with SVEP1. Probably interacts with PEX11A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Golgi apparatus membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:structural molecule activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular protein transport"/>
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    </dbReference>
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        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Coatomer subunit alpha"/>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
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    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
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    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
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    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
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        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
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        <property type="entry name" value="TPR_COPA_B"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="5 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="17">
        <location>
            <begin position="344"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="19">
        <location>
            <begin position="626"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="18">
        <location>
            <begin position="818"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007343-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1231" mass="139552" checksum="CCA161EA19FBFA8D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKE9</accession>
    <name>A0A182PKE9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase-like protein 22</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKE9"/>
    <dbReference type="STRING" id="199890.A0A182PKE9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007416-RA">
        <property type="protein sequence ID" value="AEPI007416-PA"/>
        <property type="gene ID" value="AEPI007416"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007416"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038899">
        <property type="entry name" value="METTL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23108:SF0">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23108">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007416-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33416" checksum="0DBFAB6091601284" modified="2016-09-07" version="1">MSVLEVTSELYGEAEFCSTDTGNGNAISKFTFVYPNRRDCAATVNGGSQSEQTNGMDKRNDQIEADREEEEEEECYTASQQSQAKQPMIKLDKDGDVVVERRRKGAIEIELGSGVGLTSIVASMYAREVICTDIDIEGLLDLIRGNVQRNAHLSNPHCRVHVTELDFKVSYQDYPRDLKTKLQDVQYVIAADVIYDDDITEAFVRTIVSLLLELPKLKAIYIALEKRYVFTLEDMDSVAPCYDYFLRYFEKRNGRFGVNRWKLINVCMNFPRYFDYDKVKDLVLLKVCHASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKM9</accession>
    <name>A0A182PKM9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ClpX-type ZB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKM9"/>
    <dbReference type="STRING" id="199890.A0A182PKM9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007496-RA">
        <property type="protein sequence ID" value="AEPI007496-PA"/>
        <property type="gene ID" value="AEPI007496"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007496"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19497">
        <property type="entry name" value="RecA-like_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000002">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000378">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059188">
        <property type="entry name" value="Znf_CLPX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059067">
        <property type="entry name" value="Znf_ribbon_CLPX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003745">
        <property type="entry name" value="PRK05342.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26040">
        <property type="entry name" value="Zn_ribbon_CLPX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="7">
        <location>
            <begin position="134"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="144"/>
        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007496-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="666" mass="70976" checksum="47E43D1044DAEC2E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL59</accession>
    <name>A0A182PL59_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PL59"/>
    <dbReference type="STRING" id="199890.A0A182PL59"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007676-RA">
        <property type="protein sequence ID" value="AEPI007676-PA"/>
        <property type="gene ID" value="AEPI007676"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007676"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
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        </location>
    </feature>
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            <end position="208"/>
        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007676-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1112" mass="115843" checksum="7D3C2E8A6A1901EC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLC5</accession>
    <name>A0A182PLC5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLC5"/>
    <dbReference type="STRING" id="199890.A0A182PLC5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007743-RA">
        <property type="protein sequence ID" value="AEPI007743-PA"/>
        <property type="gene ID" value="AEPI007743"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007743"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007743-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="180" mass="21069" checksum="5CAA44264179E79B" modified="2016-09-07" version="1">MFISSRVLCLYFVAFAVTINCLEILFEQFEQFSGFVMVDMQLRVRKFNRTMTTLNGTIFIRQPISNEVVFQTELFQSRLGNQQFNHYPAKLPTCGFCDFFDNLHNMYEEHISDIVNVPRQNECPVQVREAHILDKRFPSSVLPPVCPPGLWKIVISGRLEDAEKLNYHMVLKVYEKDFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLG8</accession>
    <name>A0A182PLG8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLG8"/>
    <dbReference type="STRING" id="199890.A0A182PLG8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007788-RA">
        <property type="protein sequence ID" value="AEPI007788-PA"/>
        <property type="gene ID" value="AEPI007788"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007788"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000343">
        <property type="entry name" value="CCR4-NOT transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="48"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007788-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="167" mass="18975" checksum="329F5F570BAF6FEB" modified="2016-09-07" version="1">MSRNKDKYESNNPRRQQTFLTAEDIAAGKKTCWHGIEITGSVRNLSPTLWKFEHLTALFLNDNCLTRLPHQIGQLANLRTLDLSANKLRSLPAELGELIQLRELLLNNNYLRVLPYELGKLFNLHVLGLHGNPLGKDVLSIYNEPNGTSKLLTYMLDNLSDEILPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLS0</accession>
    <name>A0A182PLS0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLS0"/>
    <dbReference type="STRING" id="199890.A0A182PLS0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007892-RA">
        <property type="protein sequence ID" value="AEPI007892-PA"/>
        <property type="gene ID" value="AEPI007892"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007892"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052792">
        <property type="entry name" value="Thioredoxin_dom-contain_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46497">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46497:SF1">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="225"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="849"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007892-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1057" mass="119432" checksum="C3861C1AA9807E85" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLY5</accession>
    <name>A0A182PLY5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c oxidase assembly factor 7 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hcp beta-lactamase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLY5"/>
    <dbReference type="STRING" id="199890.A0A182PLY5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007957-RA">
        <property type="protein sequence ID" value="AEPI007957-PA"/>
        <property type="gene ID" value="AEPI007957"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007957"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040239">
        <property type="entry name" value="HcpB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007957-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29480" checksum="B2942C93CE7FAE11" modified="2016-09-07" version="1">MSSFDLKNESEVKEYIDKLGVEYRFGCYSEKKPEVCHLLGDYLEGIRKDFEKAAKVYRSNCDDYSYGKSCLKYGNYTFLGKGRTSEKGDPAKAYAYYEKGCALNDPDACLHSGLLLVSKLMPKEITRDVPKGFELLKKSCEMNNAGACFYLSGMYISGVLKEEYQQAAKKGDGATPAATEQRPPGAYVVERNMEKAFEFAYKACELRNMYACANLSQMYAKGDGTPRDEKKAEKYKKLALEMQDEVKKQQQLTFQQGLNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMG6</accession>
    <name>A0A182PMG6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMG6"/>
    <dbReference type="STRING" id="199890.A0A182PMG6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008139-RA">
        <property type="protein sequence ID" value="AEPI008139-PA"/>
        <property type="gene ID" value="AEPI008139"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008139"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008139-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="85" mass="9365" checksum="19EAEB97EB403DCB" modified="2016-09-07" version="1">MAHEIAPEDGLPTVVCSSCRDQLESCHRFRRVAHRTQKSLQSYLAYAAALAGSEEGPLPARNDVVFPYNTVITVAIIICPEHDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMG9</accession>
    <name>A0A182PMG9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNTTIP1_dimer domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMG9"/>
    <dbReference type="STRING" id="199890.A0A182PMG9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008142-RA">
        <property type="protein sequence ID" value="AEPI008142-PA"/>
        <property type="gene ID" value="AEPI008142"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008142"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041384">
        <property type="entry name" value="DNTTIP1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026064">
        <property type="entry name" value="TdIF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049121">
        <property type="entry name" value="TdIF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399:SF2">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18192">
        <property type="entry name" value="DNTTIP1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21229">
        <property type="entry name" value="TdIF1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNTTIP1 dimerisation" evidence="5">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="TdIF1 C-terminal" evidence="6">
        <location>
            <begin position="221"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008142-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="400" mass="43427" checksum="2A44652477E5A891" modified="2016-09-07" version="1">MRQKLKNALSGEATLEALKQRYGTGRSFISQTANDAAIKSLELLRANIQCCFDKEVDTIVKKFHQTYFVPAIRNIKENLGEGAISDEALKSVFCSLLENTKAQYAGQLSSPAGNSLSRANTPGMELSDSDSSTDNAPTAGAATSLLHQALKRKLPEPNQPDLFKRQYFLHGPIFPHATYQSLTAQQSQQASGGGTGGSSNLATTTSSRHLSLPTTVITPESLFILDFKAARLLGIPDLRDRLANKHPEVLRYCPDTQDRDWLLQQRQVTPLNKNGRFFLLALDDVKKLVERNAFEHAPAATASRLAELQGFKVTELIYAKIQKLLKELTERQRAADGFESPKGVPSTAAVSRPRISSLSSSHATLTALLSTPHQPQAASESSVGNSSAAVLESGGELKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMP1</accession>
    <name>A0A182PMP1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ubiquitin-fold modifier-conjugating enzyme 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMP1"/>
    <dbReference type="STRING" id="199890.A0A182PMP1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008215-RA">
        <property type="protein sequence ID" value="AEPI008215-PA"/>
        <property type="gene ID" value="AEPI008215"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008215"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061657">
        <property type="term" value="F:UFM1 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11686">
        <property type="entry name" value="UBCc_UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000042">
        <property type="entry name" value="Ubiquitin-fold modifier-conjugating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014806">
        <property type="entry name" value="Ufc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08694">
        <property type="entry name" value="UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008716">
        <property type="entry name" value="DUF1782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR008716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR008716-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008215-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="169" mass="19541" checksum="D9FFF7307843A99B" modified="2016-09-07" version="1">MVDEVRRKELSSIPLCRTKAGPRDKELWVQRLKEEYQALIQYVQNSKAADMEWFRLESNKEGTKWFGKCWYIHQMHKYEFDVEFDIPITYPTTSPEIALPELDGKTAKMYRGGKICLTDHFKPLWAKNVPKFGIAHAMSLGLAPWLAVEIPDLVEKGVITYQEKGSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMP4</accession>
    <name>A0A182PMP4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PMP4"/>
    <dbReference type="STRING" id="199890.A0A182PMP4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008218-RA">
        <property type="protein sequence ID" value="AEPI008218-PA"/>
        <property type="gene ID" value="AEPI008218"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008218"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029901">
        <property type="entry name" value="Spire"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345:SF3">
        <property type="entry name" value="PROTEIN SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345">
        <property type="entry name" value="SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008218-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="125" mass="14980" checksum="FB4B57B6CFC8CAC6" modified="2016-09-07" version="1">MARFWMQVVDELRRGVRLKKINFSRTPIEYELTPYEILMEDIRSRKYNLRKVMVNGDIPPRVKKDAHAVILEFIRSRPPLRKASERKLAPQPLKRVFCPREQLLDSIRKGRVLKPVNQKLKSRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMU9</accession>
    <name>A0A182PMU9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMU9"/>
    <dbReference type="STRING" id="199890.A0A182PMU9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008273-RA">
        <property type="protein sequence ID" value="AEPI008273-PA"/>
        <property type="gene ID" value="AEPI008273"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008273"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="38"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008273-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="558" mass="61323" checksum="201F6281B8373E97" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN36</accession>
    <name>A0A182PN36_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pickpocket</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN36"/>
    <dbReference type="STRING" id="199890.A0A182PN36"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008360-RA">
        <property type="protein sequence ID" value="AEPI008360-PA"/>
        <property type="gene ID" value="AEPI008360"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008360"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008360-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="66603" checksum="A02B82A0CDE5227A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN37</accession>
    <name>A0A182PN37_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pickpocket</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN37"/>
    <dbReference type="STRING" id="199890.A0A182PN37"/>
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        <property type="protein sequence ID" value="AEPI008361-PA"/>
        <property type="gene ID" value="AEPI008361"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008361"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="500"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008361-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="65920" checksum="11AC0F253BCD2DF5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN80</accession>
    <name>A0A182PN80_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcription factor grauzone</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PN80"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008405-RA">
        <property type="protein sequence ID" value="AEPI008405-PA"/>
        <property type="gene ID" value="AEPI008405"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008405"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="455"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="736"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="852"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="882"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="910"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="938"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1222"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1253"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1278"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1307"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1338"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1368"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1396"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1424"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="572"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1108"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="620"/>
            <end position="630"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1131"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1145"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008405-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1476" mass="173313" checksum="19002A357DF65F50" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNA3</accession>
    <name>A0A182PNA3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNA3"/>
    <dbReference type="STRING" id="199890.A0A182PNA3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008428-RA">
        <property type="protein sequence ID" value="AEPI008428-PA"/>
        <property type="gene ID" value="AEPI008428"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008428"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF237">
        <property type="entry name" value="CUTICULAR PROTEIN 65AU, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131563" evidence="4">
        <location>
            <begin position="18"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008428-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="292" mass="31196" checksum="3AEBD2C6D99CD583" modified="2016-09-07" version="1">MFRKLIVASLMVSLVVALPQRSLSRGGGGGGGGDEAGAETLAQDTVINADGSYTYNYETSNGISASQASDDGTNANGNFAFTAPDGQRYEIVYIADENGFQPQGAHLPTEPPAPDHVIKMLEDMLANPPEGADIDTKPPRPIPFAMFRFVFAAAALLVATAVAGPLDRAYSHQQSPDAHAQIVSYENVLKDDGHYNWSYETSNGIAAHEDGLGAHAANGAFSYTGPDGVLYRVVYVADENGFQPQGDHLPTPPPTPEHVFKTLEQIRANPPKDQKDFSLEALDATIARLRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP22</accession>
    <name>A0A182PP22_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP22"/>
    <dbReference type="STRING" id="199890.A0A182PP22"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008701-RA">
        <property type="protein sequence ID" value="AEPI008701-PA"/>
        <property type="gene ID" value="AEPI008701"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008701"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF134">
        <property type="entry name" value="AGAP011908-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131594" description="Peptidase S1 domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="155"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008701-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42518" checksum="74F9FA950A832907" modified="2016-09-07" version="1">MRWLCAVVLAIIAHDGLLVRAEWFDSCDRQFQLTAAADVTLNSPFFPSNYSAGSSCRFVLRAPPGYTIQATCTLNMANPTAACTTDFLYMSTEGFVSPVGSEYFCGKGQISRRSLFNKLTISYISASSTNSGSFTCRLVVQPQECDCGWTRTAKIVGGSVAGVNEFTAMVGLLDPLTVNVFCSGAIISPRYVLSAAHCTRTIPSVSRVQALVGDHDYRTGLDTPYSAIYNIEQIISHENYNDQTRNNDIALLRTSNEIDFNRGVGPICLPFLYSTYSFADLSVDIAGWGTTSFGGPMSTVLRKTTLNVLQNAICTAPYVNDQKVCTFAVGRDSCQYDSGGPLYLRGSQRMYSIGIISYGSACAASTASVATRVTSYLSWIRQNTPGESYCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPB1</accession>
    <name>A0A182PPB1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPB1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008790-RA">
        <property type="protein sequence ID" value="AEPI008790-PA"/>
        <property type="gene ID" value="AEPI008790"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008790"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131552" evidence="1">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008790-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="218" mass="24262" checksum="7F726AE39A25057D" modified="2016-09-07" version="1">MSTMRGPLRVGIIAATLLTAGLSLAAPQADPLAAQYPNGAFDDRVPNNENNQQFKQYADYLTRFDEWVTGKKVPIPADPVTDSLHQELPLDVPNFAQLRPVRQIPAGFDDPVPQGSEAIPEYNEYIRVLTRFDPYVAGHAVFKRENTKPDETLISKEKGFGEHIEDKVPETSTSSDPAYGEFIKELKRFDPWLVGRNVTIPHNTTADQVWNSGEGKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPI0</accession>
    <name>A0A182PPI0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPI0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008859-RA">
        <property type="protein sequence ID" value="AEPI008859-PA"/>
        <property type="gene ID" value="AEPI008859"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008859"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008859-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="420" mass="45685" checksum="224B83A92488F733" modified="2016-09-07" version="1">MYAAAGGASLASRQARKKQAQQNTKNKATNQQILREKLAAKAATTPTKSKHFHQLPASYLRAPHQHHRKLSAGYTSIPGSEQPPPPPHHRFADHPCASYTGPSVGTPGAHHAHGPPHHLAGHAHHHHHHHHGAGPPGVGGGVPHPCHLHGAGPSGHPPASGASFPPMPKPTGFREYDKLVRRQQLTKSATATLPLVSQAQDTPPQTPTLGFGETSEPHGHGHHHPPQQLLLLEQQQQHHFHHSQQNLDKLGASGQPEEAESAALTQPLTLQIPNDPIIITPATPQATPPGRLGLKPLVLTDDEEARPLTSPTPGALERKCSVYRGRKLDPFEEQFYNATTINNAHQQQHHHQQQYHPDDVYFSPVGGSVPNGHSTTTTTPGHQQLAKWDSEYYCCECDHRQYGVCTCDQFEVSDALRCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPL2</accession>
    <name>A0A182PPL2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPL2"/>
    <dbReference type="STRING" id="199890.A0A182PPL2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008891-RA">
        <property type="protein sequence ID" value="AEPI008891-PA"/>
        <property type="gene ID" value="AEPI008891"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008891"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03079">
        <property type="entry name" value="GST_N_Metaxin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF38">
        <property type="entry name" value="METAXIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="407"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="560"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008891-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="72131" checksum="31255FEBDE5F6E55" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPN2</accession>
    <name>A0A182PPN2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPN2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008911-RA">
        <property type="protein sequence ID" value="AEPI008911-PA"/>
        <property type="gene ID" value="AEPI008911"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008911"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008911-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="361" mass="38665" checksum="7376C780F95FEEF0" modified="2016-09-07" version="1">MEENGKSVAHPFASQKVDKLILEETEAGRRFLATLRRNHERELEASDGPGTRELTAAVNGGSASRHEGGTFVASRSLAKDKRSSLRATLEHLIVRYLRRLTSDDDADGDDGGDEPGGYEAAARYRRQSLPADSGGGVAMAVPDGSPSSSPAFEFSNSMEITLLTNDTDTNQTDVWDDGGWLEEGGGGNRAANQQPLGSSPLTAETGEIENSASAEGYGSASGPSVAGLVQGVREVLGQGSVGEPRGDSDDRAGDGANGDSEFRGNGDEVEYNPPHIGGGVESADEQIGELRQQRKKEKTKSATKRGECTSVRKRVSQLDRFELERSMRNGSFREYNIRNALNYRMLPVMLDAKSINSDPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ32</accession>
    <name>A0A182PQ32_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQ32"/>
    <dbReference type="STRING" id="199890.A0A182PQ32"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009062-RA">
        <property type="protein sequence ID" value="AEPI009062-PA"/>
        <property type="gene ID" value="AEPI009062"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009062"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009062-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="251" mass="28839" checksum="CB121D780D5EDF6D" modified="2016-09-07" version="1">MICKECLTTLCAFRDYRERCLEHLFNNLSEDNVQDGSTEHDGSAQIAKLTTEEIVSSCSQSTAKDDPKPSPVGFTKTFQTIVTSANGKKRYIYDCKQTYQKQLVECDICHKSFAKTRLEGHRNVHLGLRPWNCERGCEQRFHCKQLLLHHYRNVHGGEPHCCDVCGKVLRSKRSLGYHIKDSHGEKKHPCSFCGQLFVSNARLNQHIKYHRDERNYPCDQCKCSFFSSNDLKKHSATHKKQRPEGHGKHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ73</accession>
    <name>A0A182PQ73_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQ73"/>
    <dbReference type="STRING" id="199890.A0A182PQ73"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009103-RA">
        <property type="protein sequence ID" value="AEPI009103-PA"/>
        <property type="gene ID" value="AEPI009103"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009103"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13248">
        <property type="entry name" value="PH_PEPP1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040392">
        <property type="entry name" value="PKHA4-7_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752:SF9">
        <property type="entry name" value="KRAMER, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752">
        <property type="entry name" value="PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="328"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009103-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="842" mass="90811" checksum="E7C1245AFBAB1634" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQV7</accession>
    <name>A0A182PQV7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="3">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-binding domain-containing protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Diphthamide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein DPH6 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Diphthine--ammonia ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PQV7"/>
    <dbReference type="STRING" id="199890.A0A182PQV7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009338-RA">
        <property type="protein sequence ID" value="AEPI009338-PA"/>
        <property type="gene ID" value="AEPI009338"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009338"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000010">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000002">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000012">
        <property type="entry name" value="diphthine--ammonia ligase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="748"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009338-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="848" mass="93364" checksum="5F575C52957C684F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR97</accession>
    <name>A0A182PR97_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein TSR2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in 20S pre-rRNA processing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PR97"/>
    <dbReference type="STRING" id="199890.A0A182PR97"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009479-RA">
        <property type="protein sequence ID" value="AEPI009479-PA"/>
        <property type="gene ID" value="AEPI009479"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009479"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009479-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="194" mass="22121" checksum="1662AA114B07BC20" modified="2016-09-07" version="1">MANRQALQQVFRVVVENVLNRWTALRLAVEHGMGGPLGLNTAIELIDYITSYCTENKNVDAIDLRDVLEEIMDQEFETICEDESTQEVSAVLIKYLRMLKEGKEEEVKAEIHMMVPCEMWIVSGSKIKYQRMDDSSSESDEDTNDQEDMDVEPASALDVSTEQVNPSTCGSSTKFVEEESFDPGWTQVRGRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRL1</accession>
    <name>A0A182PRL1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ell-associated factor Eaf</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes transcriptional elongation by Su(Tpl)/ELL. Essential for development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRL1"/>
    <dbReference type="STRING" id="199890.A0A182PRL1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009595-RA">
        <property type="protein sequence ID" value="AEPI009595-PA"/>
        <property type="gene ID" value="AEPI009595"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009595"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027093">
        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF2">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="11">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009595-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="290" mass="30461" checksum="E65CE94ACBF680F5" modified="2016-09-07" version="1">MDNRLNIGSEVRELKLGSTFSNAGPSNQFHTIKYDFKPASVDVNKPAVLEISANKQVTVTVPHLDGSGVPNTVFKGNQREYSRKDCVLIAPNPPPTLPTIKVENNTARQSSKTKITTGVRKNAPISFMPKHSPLQGSPSYPHRSPQSAPAWNANNTQQTLPSIPMIGLDDGLDFGTVAPPSSASSSSSSSSSANASSDRELLPPPVAVTGIGVGATSDPEMMTSSESDGSDDSDSSSSDQESDSSTEDNNDSPVKESIFDPRPDPTVAVTAAAVDLSKDLCLSSNSDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRU3</accession>
    <name>A0A182PRU3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCDC174 alpha/beta GRSR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRU3"/>
    <dbReference type="STRING" id="199890.A0A182PRU3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009678-RA">
        <property type="protein sequence ID" value="AEPI009678-PA"/>
        <property type="gene ID" value="AEPI009678"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009678"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057464">
        <property type="entry name" value="CCDC174_GRSR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25449">
        <property type="entry name" value="CCDC174_GRSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC174 alpha/beta GRSR" evidence="3">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009678-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="276" mass="31068" checksum="650EC5AE9FB8A6B2" modified="2016-09-07" version="1">MNDPNRKIEIDKSSLLSLKAELLRKQEEVGKAKASTSIDDFVPKKVPKAEKNASTARKERREKKDNSKPIVTELEDSSQLARSKQMLKAKAKYYDRMLAAGGSLNSDENSLVMFNKKKQDTKPAYYSSSEPSTDESSADSESSDSEGVEDGDKWVEYTDFLGRTRKCLKKDLKECLTRDRELAKSMVPREGQRREDLQGPASINTQMPASQVPPTASIDHEEEEEGGDGEIVGPMPPTMNQSGDMEIGERFREMKEHPHSPELSYILWKKMSSLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSY8</accession>
    <name>A0A182PSY8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSY8"/>
    <dbReference type="STRING" id="199890.A0A182PSY8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010074-RA">
        <property type="protein sequence ID" value="AEPI010074-PA"/>
        <property type="gene ID" value="AEPI010074"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010074"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF167">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="168"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010074-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="433" mass="48352" checksum="C4E7D2CB2ED410B5" modified="2016-09-07" version="1">MASSPVCTISFDDNCYGVFFAGQKLAGTVDIDLPKTKKVKVTGVASVLWTETYGTGTTIPFEGREDFLTHTIDFVRSNTDEPIVMEPGRQIYRFDLQLPDVLPTSFEGDYGYIRYTARVVFERPWKFNLTYKIAFTVVNQLNLNAVSPPLNVAVVQENIKHFYCGPCRSQPLTINVMLPMTGYVPGQFILVTVDISNGSNKRIAEVKIKLRRQVKYCSQSPYERKRSVYCTLAKFQCSGVDAKGSAGYERRLLVPSEPPTRSNTIIQIEYFVEVTAKVLGMAYSPEVKIPITIGTVPLINLSQTQHRSSVVEAHLTTASSLPRKIFHSSVPSLVIPHTFEKSAGRTDVNIDDDDESPSMGTVPFSPRYPMYHFDADNKPAMLQKKHHQSTLNATMQNPSSANRCTYAHIRLHILTDAAPGTTALLDLRLPKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUB0</accession>
    <name>A0A182PUB0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein tweety homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUB0"/>
    <dbReference type="STRING" id="199890.A0A182PUB0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010546-RA">
        <property type="protein sequence ID" value="AEPI010546-PA"/>
        <property type="gene ID" value="AEPI010546"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010546"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010546-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="369" mass="38508" checksum="4545ECAF31E30C0B" modified="2016-09-07" version="1">MQQLQQRAMLDPATAAAAAAHHLHLHQQQHAGGGHVHPAQTMTINRKMHGATGLAPGASHPLPPVYGDDNPPPLPPLRNPQKALPQPDATTTDAAGADKQIYIYSTAKYGKYDPNSKTAPHQYPAAMTGKTGDAPPPDKGSAGKNPNTTTFSSTPSFNSKPLPSIINCPLPDIPKSTSNGSGSTTSKDDIYVKRKLLSDHPNGSKFATLKPIPAPKIELNNLNSKQQQQPITNGANNGGTVEMAAQLPPPPPPPPPATTGNSSGSSGGSSSGYGTAGLTNSQIQSLPLPPPPLELLQQQQQQQNNSTTHPDDQGLRLPPPPTSEELRSSTMETNGANHSGDTVPNGGDSTTMADKAGHDENSFYAVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUU5</accession>
    <name>A0A182PUU5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIE subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TFIIE beta subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUU5"/>
    <dbReference type="STRING" id="199890.A0A182PUU5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010732-RA">
        <property type="protein sequence ID" value="AEPI010732-PA"/>
        <property type="gene ID" value="AEPI010732"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010732"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07977">
        <property type="entry name" value="TFIIE_beta_winged_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000177">
        <property type="entry name" value="Transcription initiation factor IIE subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016398">
        <property type="entry name" value="TFIIE-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="9">
        <location>
            <begin position="57"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010732-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="295" mass="33886" checksum="DECF1ADD76A857A5" modified="2016-09-07" version="1">MDPALLREREAFKRRAMATPTVEKKAKTESSFTTPKDIKKPRPASAAPKIDATNYKTMSGSSQYRFGVLAKIVKHMRTRHQEGDDHPLTLDEILDETNQLDIGSSVKSWLQGEALRNNPKIELTADGRYLFKSVFKIKDGKSLMRLLKQHDLKGLGGVLLDDVQESLPHCDKVLKNRASEIIFITRPNDKKKILFYNDRTANFQVDEDFQKLWRAVTVDAMDDAKIDEYLEKQGIRSMQDHGPKKPLLPKRKKLANKKRQFKKPRDNEHLADVLETYEDNTLTQSNAVQEIKQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV40</accession>
    <name>A0A182PV40_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large proline-rich protein BAG6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">BCL2-associated athanogene 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">HLA-B-associated transcript 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2).</text>
    </comment>
    <comment type="function">
        <text evidence="1">Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Component of the BAG6/BAT3 complex, also named BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with GET4; the interaction is direct and localizes BAG6 in the cytosol. Interacts with UBL4A; the interaction is direct and required for UBL4A protein stability. Interacts with AIFM1. Interacts with HSPA2. Interacts with CTCFL. Interacts with p300/EP300. Interacts (via ubiquitin-like domain) with RNF126; required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol. Interacts (via ubiquitin-like domain) with SGTA; SGTA competes with RNF126 by binding the same region of BAG6, thereby promoting deubiquitination of BAG6-target proteins and rescuing them from degradation. Interacts with ricin A chain. Interacts with VCP and AMFR; both form the VCP/p97-AMFR/gp78 complex. Interacts with SYVN1. Interacts with USP13; the interaction is direct and may mediate UBL4A deubiquitination. Interacts with ZFAND2B. Interacts with KPNA2. Interacts with UBQLN4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PV40"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010827-RA">
        <property type="protein sequence ID" value="AEPI010827-PA"/>
        <property type="gene ID" value="AEPI010827"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010827"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01809">
        <property type="entry name" value="Ubl_BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000161">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
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        <property type="entry name" value="ubiquitin"/>
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    <keyword evidence="10" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="17" id="KW-0143">Chaperone</keyword>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0221">Differentiation</keyword>
    <keyword evidence="14" id="KW-0391">Immunity</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
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            <end position="63"/>
        </location>
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        </location>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00046936"/>
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        <source>
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    <sequence length="1431" mass="150159" checksum="1343ABD57533635D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVK0</accession>
    <name>A0A182PVK0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
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        <property type="gene ID" value="AEPI010987"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
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    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
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        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
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        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_L30_N"/>
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        <property type="entry name" value="RIBOSOMAL_L30"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
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        <location>
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            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="8">
        <location>
            <begin position="120"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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        </location>
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            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="22"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="278" mass="32002" checksum="40E312F446ACAEE5" modified="2016-09-07" version="1">MADKAKSAPQAVKKPAVAKPAAKKDAKPKAAGEAKKKVKLLPAVPESWLKLGKGKKGSRPNLLLQRRKVRAVRLLRRKQNLLRAHNYEKRYLKTERGVVEQARIAKAKGNIYIPAEPKVAFVIRIRGINKVAPKVRKVLQLFRLRQINNGTFIKLNKATKNMLRIAEPYITYGYPTLKSVRHLIYKRGFVKHRHSRIPITDNFVIERKLRGHRLQCVEDMVYHIYTGGACFKKVSNFLWPFKLNTPTGGWRKKNNHYVEGGDFGNREDKINELIQRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWR9</accession>
    <name>A0A182PWR9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWR9"/>
    <dbReference type="STRING" id="199890.A0A182PWR9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011406-RA">
        <property type="protein sequence ID" value="AEPI011406-PA"/>
        <property type="gene ID" value="AEPI011406"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011406"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011406-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37373" checksum="BFFEDB3DE84A126E" modified="2016-09-07" version="1">MIPAQAPFNTITEERQTISDDEVIVHEDFDLSDAEAGNDVDDNRDINELEDVYIESDNTYRFFDNITLEEGLRYIAITKKLPRSTVNMLLALLRRKLNLRLPADSRTLLKTPTKVGLEIQHLLGGQFWYQGIETVLRNYFQDTIPQTDQFSLQVSVDGLPLFNSSARQLWPILIKVEELPNAPVMMIGVFCGFTKPNSITGFLQPMVTEVNNLQEKGMLFGDKMIHVKLRMFIADAPARCFIKATISYVGKHSCLKCSCVGIHEGSKVIFTSVDDELRTDAGFRNRVDKEHHKNWKSPLENLAEFNMIEDVIVADRLHLIDLGGTKKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWZ2</accession>
    <name>A0A182PWZ2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWZ2"/>
    <dbReference type="STRING" id="199890.A0A182PWZ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011479-RA">
        <property type="protein sequence ID" value="AEPI011479-PA"/>
        <property type="gene ID" value="AEPI011479"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011479"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="67"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011479-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="381" mass="42912" checksum="A7218267F25E8F56" modified="2025-10-08" version="2">MIVDDGHRRYRHGSQETVVNEVRQRYDVPSLRSVCKQVRRQCRTCVLLYAQPASPQMCELPAARLAAFCRPFSYTGIDYFGPMIIVNGRKTEKRWGVLFTCLTVRAVHIELVASLSTNDCLMAIRNFMARRGTPIEIVSDRGTNFVGADRELREAAERVDTVILSEFGPPDPVWKFNPPAAPHFGGSWERMIQSVKRMLARIITERHPTEAVLTAALIEVENMLNSRPLTHVPVDGEDEEPLTPNHFLLGSSAGMKPLVKPDDSAAGLRQNWRAVQYKMNDLWKKWVKSYLPTLTRRTKWFEPCKPLQLGDVVLIVDENCPRNFAYAMILTVNGELKRLERKGTITPVDFSSLAAPIVVVRKANDPLVMGLSGSVEITVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PX20</accession>
    <name>A0A182PX20_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PX20"/>
    <dbReference type="STRING" id="199890.A0A182PX20"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011507-RA">
        <property type="protein sequence ID" value="AEPI011507-PA"/>
        <property type="gene ID" value="AEPI011507"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011507"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011507-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="72" mass="7733" checksum="FF100E6FE929BB34" modified="2016-09-07" version="1">MMTLRQSLLKSENVCYNVTVRGGEAAKWGTTDDSSGAPFQLHPAKEEDDEGYGDSPVICHHPGSSYSVTCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYH7</accession>
    <name>A0A182PYH7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ZNF380 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYH7"/>
    <dbReference type="STRING" id="199890.A0A182PYH7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014378-RA">
        <property type="protein sequence ID" value="AEPI014378-PA"/>
        <property type="gene ID" value="AEPI014378"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014378"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059039">
        <property type="entry name" value="ZNF380_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23406">
        <property type="entry name" value="ZNF380_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZNF380 coiled-coil" evidence="8">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014378-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="157" mass="18246" checksum="287712C640A7C557" modified="2016-09-07" version="1">MDIEQTGIDAGSTTNAPDEEKLPEGFFDDPKMDAKARNQEYKDPNDEEWEKFQKEIKEATSVSMAIISEEQEESTAERQIAEIDEQIRNWSRVLDLEKKKEQVKTMKSVKTSARDVNQLKKIGQSMDPGNDDVREDDDDDDDDFDEFLDWRAKKSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYS3</accession>
    <name>A0A182PYS3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PYS3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014465-RA">
        <property type="protein sequence ID" value="AEPI014465-PA"/>
        <property type="gene ID" value="AEPI014465"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014465"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131962" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="23"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="81"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="137"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="202"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="266"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="324"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="378"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014465-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="437" mass="48234" checksum="B1E5AFE20F4B9A58" modified="2016-09-07" version="1">MQRLWLIVVLVEILVLREAVSNNNRCANRPDGVFINDFTACDAFFTCFRGDAFPGTCPMGFVFNEDAQLCDFPWNVKCLICPESETLEPTFEPIEGECTYYALCIQGIGALRECAPGLQFDQAAKICDLEENVNCETPICPASINPNEPVSVPHPTDCTKYYICFRGTEDERQCAPTLLFNPDTRVCDLEENVVCESGVPSPTSCPPTGIHYVGNPADCVSYFVCLNGEKSTTPTNCASGLIFDITDSVLVYTILFAAVIVSGAERNPCLGIPDGMFVNDFTTCEGYFLCLGEVPTHAQCPPGFYFNEGQQLCDFPQNVFCHVCNQQNGVQLFPHPTNCDQFITCSNGISFVGNCKAGETYDVVLQACKSEIRVDCERLRCPEVDNPNVVVFIPGIQSCDEYFLCQAGTPIQRFCAPGLHWNRVAERCDFPELAQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYX6</accession>
    <name>A0A182PYX6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-maleylacetoacetate = 4-fumarylacetoacetate</text>
            <dbReference type="Rhea" id="RHEA:14817"/>
            <dbReference type="ChEBI" id="CHEBI:17105"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="EC" id="5.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYX6"/>
    <dbReference type="STRING" id="199890.A0A182PYX6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015044-RA">
        <property type="protein sequence ID" value="AEPI015044-PA"/>
        <property type="gene ID" value="AEPI015044"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015044"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03042">
        <property type="entry name" value="GST_N_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000010">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000041">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034333">
        <property type="entry name" value="GST_Zeta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="GST N-terminal" evidence="12">
        <location>
            <begin position="50"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="13">
        <location>
            <begin position="138"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015044-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="262" mass="29749" checksum="E7C0FCC6729CDD4A" modified="2017-10-25" version="2">MPAIFTFLPKNVLGAATASLKQFPLLQSFTHGSKINYSKFHGSMSLSAMSKPILYSYWRSSCSWRVRIALNLKEIPYDIKPISLIKSGGEQHCNEYREVNPMEQVPALQIDGHTLIESVSIMYYLEETRPQRPLMPQDVLKRAKVREICEVIASGVQPLQNLIVLIHVGEEKKKEWAQHWITRGFRAIEKLLSTSAGKFCVGDEITLADCCLVPQVFNARRFHVDLRPYPIILRIDRELEGHPAFRAAHPSNQPDCPPEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ53</accession>
    <name>A0A182PZ53_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZ53"/>
    <dbReference type="STRING" id="199890.A0A182PZ53"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015118-RA">
        <property type="protein sequence ID" value="AEPI015118-PA"/>
        <property type="gene ID" value="AEPI015118"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015118"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015118-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="389" mass="44725" checksum="F2EE4B28B5C749AB" modified="2016-09-07" version="1">MKFLRQEQPAGVPHIAIKLLKVFGITDRPEERFRILPVMLTYVLIIVVPKSFYGYPNFELGIIGIAELFFQTNTFVGIFLLFLNRRKLDQLFSQARSFSQTVLRESPPAVVQHLTTQHGMIHKITRLFCIVVMYAAHFYVFAPFLSTLYTFFTMVQQDGNETMHYTLQMEENFYGLTIRTSAPHYFLFGLVMTPTCYLCALTGTVKTLTVCNITIYCTLYFQLVQVRLRTADTQSNAFHQELKAIVKMHQDALNCASLLESITSLVLLQQLLLCVLIWSSMLLYFTVSGFNVNFMSLFVLFVFDTTETFAYCYLGEQLSNESARVARTVYESSWETQTTAIQKDLQLVLVRAQSPVGITAGKFCYMNMEQFGIILKTTYSFFVILRDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PKC2</accession>
    <name>A0A240PKC2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PKC2"/>
    <dbReference type="STRING" id="199890.A0A240PKC2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015397-RA">
        <property type="protein sequence ID" value="AEPI015397-PA"/>
        <property type="gene ID" value="AEPI015397"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015397"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="55"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="133"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015397-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25641" checksum="EDD6FF1200A2B793" modified="2017-10-25" version="1">MLKDSFQKRIQSILKSGLTQPILKLDQTTEPTPQEAFELLTQATRMLRENYFVRHEKARQEIEKREHVLKLLKQQQLSDIDELQVEKQKIRATAERLAETYEDLCDKQNSLFKRAQEVVRLATLRLPKGSFSEKQFTERIEKINQSVKKLQKNVDQAKQKIQTQQIELETKKKSAKEKTFTLPVKQEDIIKQIIGEMYTQIDSNVKDVKKMNNILNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PL00</accession>
    <name>A0A240PL00_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">tRNA (guanine(10)-N(2))-methyltransferase TRMT11</fullName>
            <ecNumber evidence="12">2.1.1.214</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">tRNA methyltransferase 11 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine(10) in tRNA + S-adenosyl-L-methionine = N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43128"/>
            <dbReference type="Rhea" id="RHEA-COMP:10355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.214"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:43129"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the heterodimeric TRMT11-TRM112 methyltransferase complex; this complex forms an active tRNA methyltransferase, where TRMT112 acts as an activator of the catalytic subunit TRMT11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A240PL00"/>
    <dbReference type="STRING" id="199890.A0A240PL00"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015296-RA">
        <property type="protein sequence ID" value="AEPI015296-PA"/>
        <property type="gene ID" value="AEPI015296"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015296"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000468">
        <property type="entry name" value="SD03208p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="18">
        <location>
            <begin position="6"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="17">
        <location>
            <begin position="192"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015296-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="488" mass="56146" checksum="E8BCA94EA41A0CFD" modified="2017-10-25" version="1">MSGALKKYVLWFAQEHVDFRQAEIASLLRIWNIQMNTPANHDPDRPFWLVELQNDEAARKLASRSMSLRCIFELWAYSNQGLTNFHEQLRRHIETNGNTLAPHFEANKSFKITVETYNKHFSQKEKVAKIETMQYLPVEGPVNLKTPDVHYWYIEFWGLDPMDVPEQPYDVLFGRWIADGKRDMINEISLKTRKFIGNTSMDPQLSLLMANQGLVQGGDLVFDPFAGSGSLLVAAAKFGAYVVGADIDYMIVHGKSKPTRVNQKVREKDESIYANLQQYGCGGLFVDVLIADFSRSIWADSILFDSIITDPPYGIREATERIEFKTQRRATAMTEDAVHYPSTSPYQLCQMYKDLLQFSARHLKLGGRLVCWFPMLRKDAGSDVLPRHKCLQLVANSEQPLSGYSSRRLLTYEKISDSEADLNAFEMPETVVENFRERYFTQLAEDNGTRKERRLALRETGRKEAKKRGKQQQPDGKWRFPQDVSRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PL20</accession>
    <name>A0A240PL20_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PL20"/>
    <dbReference type="STRING" id="199890.A0A240PL20"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015366-RA">
        <property type="protein sequence ID" value="AEPI015366-PA"/>
        <property type="gene ID" value="AEPI015366"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015366"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF136">
        <property type="entry name" value="GH06673P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012737824" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="60"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015366-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="298" mass="32155" checksum="B927966FAFCA47BB" modified="2017-10-25" version="1">MKTTLSLLLIVAVLSTVHSIGVDPRTIDWTLVRTLHQTDAVRAKQGLPSLSDDEVRSARIADGQIASPTQFPWAAGVLISGSSSHSFCSGVLISRRHVLTAAVCISGSNTLTVLLGASDMKSVEEFIGVSNILSHPNYSSFFNRDDIAILTLAHEAPIRDTIRPIDLPRRSQIGNSFDSWAATSAGWGNSGRRDNEPIPITNLQFATDAVTSNFRCGLSHTFIRSTHICTATNNGGPCNGDEGGPVTVTESGRTFLIGIHSFHFSGLFGCDRGRPSVHTRITEYLDWIQQNSDAIVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FGV0</accession>
    <name>A0A9I3FGV0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cecropin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A9I3FGV0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015479-RA">
        <property type="protein sequence ID" value="AEPI015479-PA"/>
        <property type="gene ID" value="AEPI015479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020400">
        <property type="entry name" value="CecC/Srx/CECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38329">
        <property type="entry name" value="CECROPIN-A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38329:SF1">
        <property type="entry name" value="CECROPIN-A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4 8" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6 8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5 8" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039924738" evidence="9">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015479-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="67" mass="7433" checksum="755263370155A03C" modified="2023-06-28" version="1">MNLSKLLVVMLLATLLLFGGHTEAGVLKKLGKKLEKVGKNVLRAAERVVPLLLSIQDLRDKEKRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZL2</accession>
    <name>A0A182NZL2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transferrin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZL2"/>
    <dbReference type="STRING" id="199890.A0A182NZL2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000093-RA">
        <property type="protein sequence ID" value="AEPI000093-PA"/>
        <property type="gene ID" value="AEPI000093"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000093"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13529">
        <property type="entry name" value="PBP2_transferrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016357">
        <property type="entry name" value="Transferrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001156">
        <property type="entry name" value="Transferrin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485:SF54">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00405">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002549">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00422">
        <property type="entry name" value="TRANSFERRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00094">
        <property type="entry name" value="TR_FER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51408">
        <property type="entry name" value="TRANSFERRIN_LIKE_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="8">
        <location>
            <begin position="12"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="8">
        <location>
            <begin position="350"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="118"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="353"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="457"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="490"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002549-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002549-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002549-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000093-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="681" mass="76315" checksum="97C7A874868FCFB7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZT0</accession>
    <name>A0A182NZT0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P061</accession>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="10">Epiroticus2</strain>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="454" mass="53548" checksum="20CADDED275B335D" modified="2016-09-07" version="1">MLQTNSADDQTLQLNFRMLERVLRFVAAWPTDFNPYLPKYLRGRYFLSELFDFCYLLFWYFICVHIAAFHIVSIATIDFSYDELFLTLITTSIYSIMLALNVYLRVYESNFRQLYEFSIRRFRKRSDAGVHYISISSCYRFTNRFQFWWLVMCVLGTMHWAIYPILSQERTLPFPCWYPVDVQQSPMYELAYIFQVLGQLQVGLVYGLSGALFMVFVFMVCTQFDMLCCSLTNIRQTAMILNGGYKTLLRHCQDVIEVDSRGYVLQEVFREDLDNAQATKTISKLDQLSPAQSYLMELAPELTCVMEDCIKHHLLLLRFCQLLEECYHPYVLLKLFQILLLLCFLAFMATVESLSTMKLINVLEYFMLTMTELYLFCFLGQILTNQGLKVGDALWKSPWHLCGASYRRRLLIILMNAQRPVRLTGLKLYELNLETYYAVLKAAFSYYTIIKKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0G6</accession>
    <name>A0A182P0G6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0G6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000398-RA">
        <property type="protein sequence ID" value="AEPI000398-PA"/>
        <property type="gene ID" value="AEPI000398"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000398"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130770" evidence="1">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000398-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="165" mass="16307" checksum="34086A6F5A1B317E" modified="2016-09-07" version="1">MKAVYVVALCVCLAVATQAAPQFGGIANLLNNVGQIITGLVSQLTTLVNNVIAAGGAATQTIVANVLSLVFALGNTVFTLIAVPSSALQVASGLLNNALAQISSIVAGAGTTLTTLVPALGNVQTVLLTLANNLAALNQTGLTTLQTTLVQLANTLGTVAGQISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0Q1</accession>
    <name>A0A182P0Q1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0Q1"/>
    <dbReference type="STRING" id="199890.A0A182P0Q1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000483-RA">
        <property type="protein sequence ID" value="AEPI000483-PA"/>
        <property type="gene ID" value="AEPI000483"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000483"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="59"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="125"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000483-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="193" mass="20408" checksum="BF5160B1BB94FD7F" modified="2016-09-07" version="1">MISLRTVCSLSRAASLTRRQIATNAVRNAEAAVASSGAEKLTIPVPEGVDKPADPKLVSIVDSIAKLNLLEVSELSTLLKRKLNLPDTAMMPAGFGAFAGAGGAGPAAAAADEEEAAPKVVKTTFKVKLVKFDEKQKVALIKEVKNLLEGMNLVQAKKFVESAPTVVKEDIPKEEAEKLKEAFTKVGAVIEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P184</accession>
    <name>A0A182P184_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyisourate hydrolase</fullName>
            <ecNumber evidence="5">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182P184"/>
    <dbReference type="STRING" id="199890.A0A182P184"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000666-RA">
        <property type="protein sequence ID" value="AEPI000666-PA"/>
        <property type="gene ID" value="AEPI000666"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000666"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130671" description="hydroxyisourate hydrolase" evidence="9">
        <location>
            <begin position="40"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="10">
        <location>
            <begin position="57"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000666-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="173" mass="18694" checksum="91CFE25292D2BC38" modified="2016-09-07" version="1">MRSASSCCARHQHRHLARVALSVALTALLIATTAAAAAASISSSSGSTDDAAPEDATVMQNLSTHILDTTRGKPAPEVPVTLYVRTTSQTWTKVSTGITDGDGRFKSFFAEGQPGLQLGVYKLHFDVAQYFRARSVESLYPFIEIVFSVADPSQHYHIPLLLNPFGYSTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1D0</accession>
    <name>A0A182P1D0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="STRING" id="199890.A0A182P1D0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000712-RA">
        <property type="protein sequence ID" value="AEPI000712-PA"/>
        <property type="gene ID" value="AEPI000712"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000712"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000193">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055163">
        <property type="entry name" value="ALK/LTK-like_GRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF146">
        <property type="entry name" value="RT07201P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12810">
        <property type="entry name" value="ALK_LTK_GRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1190"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="19">
        <location>
            <begin position="380"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="19">
        <location>
            <begin position="600"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="89"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1015"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1461"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1534"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1584"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1467"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1534"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1584"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1606"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1625"/>
            <end position="1641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000712-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1655" mass="176235" checksum="42BC79E8756DDA15" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1F1</accession>
    <name>A0A182P1F1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinase</fullName>
            <ecNumber evidence="8">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57660"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.140"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A182P1F1"/>
    <dbReference type="STRING" id="199890.A0A182P1F1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000733-RA">
        <property type="protein sequence ID" value="AEPI000733-PA"/>
        <property type="gene ID" value="AEPI000733"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000733"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047326">
        <property type="term" value="F:inositol-1,3,4,6-tetrakisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF51">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="631"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000733-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="776" mass="87328" checksum="F34ABA8D0CAB4F2A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1G6</accession>
    <name>A0A182P1G6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1G6"/>
    <dbReference type="STRING" id="199890.A0A182P1G6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000748-RA">
        <property type="protein sequence ID" value="AEPI000748-PA"/>
        <property type="gene ID" value="AEPI000748"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000748"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000748-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="415" mass="46804" checksum="0798556EBBE80B59" modified="2016-09-07" version="1">MAVLLQCLHDRELMLGCDALLAICSLGALLQVSIATHDINVPVLVPVPHIKKIPIGIPKYEHTKGEIIKHVPEAIIKRVPVDKHVEVEKEVEVVKHVPVTKEIVVERPVEVIREVPIEKVVIEKVEVPYEVIKHVEKIKHIPVEKHVEVIKEVEEIREVPYKRYVFNKKPFPVPYNEPEEVQVPYTVPATVAPVPAVVEPAEPSLKDKFHNLAGSYLPDPVGFIKKIILFVATMAILSVSLSQAKLVKVEVPVAVPVPVPEIQHIEKRVSTIKEVKVPYIQEVPEEHVVTHVKEVPVVKEVPVVNEITVYRDVEVVKEVPVEKIVHRRVEVPVEVVREVELVREVPIIKEIPHVKVVKVIKEVPVEEVVVKDLPVAEPYPVKVPIHVPVPVQAHQLHLTKLNKFSHLHGIKNFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1M2</accession>
    <name>A0A182P1M2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-macroglobulin receptor-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1M2"/>
    <dbReference type="STRING" id="199890.A0A182P1M2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000804-RA">
        <property type="protein sequence ID" value="AEPI000804-PA"/>
        <property type="gene ID" value="AEPI000804"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000804"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="3">
        <location>
            <begin position="793"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000804-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="886" mass="100303" checksum="F63EFB6F5E86A996" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1S2</accession>
    <name>A0A182P1S2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RING-type E3 ubiquitin-protein ligase PPIL2</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">CYC4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Probable inactive peptidyl-prolyl cis-trans isomerase-like 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 26">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with PRPF8/PRP8, EFTUD2/SNU114 and PLRG1. Interacts with isoform 2 of BSG. Interacts (via the PPIase cyclophilin-type domain) with CRNKL1; they may form a trimeric complex with HSP90.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182P1S2"/>
    <dbReference type="STRING" id="199890.A0A182P1S2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000856-RA">
        <property type="protein sequence ID" value="AEPI000856-PA"/>
        <property type="gene ID" value="AEPI000856"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000856"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000018">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="23">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="22">
        <location>
            <begin position="287"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="487"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000856-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="532" mass="59889" checksum="6E4D390926FECEAE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2T9</accession>
    <name>A0A182P2T9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2T9"/>
    <dbReference type="STRING" id="199890.A0A182P2T9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001225-RA">
        <property type="protein sequence ID" value="AEPI001225-PA"/>
        <property type="gene ID" value="AEPI001225"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001225"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000039">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF16">
        <property type="entry name" value="CBP80_20-DEPENDENT TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="246"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001225-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="484" mass="53428" checksum="D8C0EA6689EE6102" modified="2016-09-07" version="1">MAEQNENTATKKSVKIQDYISPGISRERSFIRTSNQQINNSNKRRSLAFTQSQAHQHAQQQLREGRLDGLAGMNNKLNVHAQEFQMNNLPLNDHRFPLQSSRSLNIYSSSLQHSKSSAAMPLGGMHGRSQHHALQLGSIGSPVPRGSLMMPAHTPLHHVGVQLQPSHMPLVNSPSSSNILHSSGPRVKFAPEPMLHAHAHSSNTPHASTTMNNSNNGAVGANSNTLAPLQRSKSLSSADTLSRGLASLGLGIGSEGNDIGMFSPEVQAAITKAIEDPNQLNARCLMDLATQLLHRAVEGRRYSLPISRLCISIIAKEKKETFLEALLNTCRQWYQERDKVLGVMHNSKNPSRPRFTSFMAFLTEMFCQLKRRQLQLRTECDGVPPPLVLLTVLGKCCEDCVQPPVRSLSEIECLFFVLTCIGRDLETHLPQQLESLLAGVRDAFLNSAASAPAIRRTLLQLIELQASHWQLPGNTVLYYYPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2X8</accession>
    <name>A0A182P2X8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M12B propeptide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2X8"/>
    <dbReference type="STRING" id="199890.A0A182P2X8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001264-RA">
        <property type="protein sequence ID" value="AEPI001264-PA"/>
        <property type="gene ID" value="AEPI001264"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001264"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF3">
        <property type="entry name" value="KUZBANIAN-LIKE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001264-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14780" checksum="E0A0502F37F83ECD" modified="2016-09-07" version="1">MQETYSSTPTLATGGADSTINPFIRYWEPARFDRGLLDLAHQHHEQHRRRRRSINYEHGSAAYGPANVVRLNFRAHDREFRLVLREDPRSVFSRDVQIENTEGPLDYDLSRIYTGTVEASCEPSFGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3E3</accession>
    <name>A0A182P3E3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trimethyllysine dioxygenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182P3E3"/>
    <dbReference type="STRING" id="199890.A0A182P3E3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001428-RA">
        <property type="protein sequence ID" value="AEPI001428-PA"/>
        <property type="gene ID" value="AEPI001428"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001428"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000020">
        <property type="entry name" value="GG15479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="14 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="22">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="269"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001428-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="735" mass="83060" checksum="24460067D0ABD468" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3Q7</accession>
    <name>A0A182P3Q7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P3Q7"/>
    <dbReference type="STRING" id="199890.A0A182P3Q7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001542-RA">
        <property type="protein sequence ID" value="AEPI001542-PA"/>
        <property type="gene ID" value="AEPI001542"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001542"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22419">
        <property type="entry name" value="KH-I_ASCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047538">
        <property type="entry name" value="KH-I_ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="60"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001542-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="643" mass="72381" checksum="FDD0CCD459F6FB62" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3S5</accession>
    <name>A0A182P3S5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3S5"/>
    <dbReference type="STRING" id="199890.A0A182P3S5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001560-RA">
        <property type="protein sequence ID" value="AEPI001560-PA"/>
        <property type="gene ID" value="AEPI001560"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001560"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001560-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="431" mass="48822" checksum="DA05FD7CD7DD5A5A" modified="2016-09-07" version="1">MQPIKSFYLFSKLFGLCPYPLDTTVPVNTRASYVKQLLPTYTVLLLYSSCLVSIFWQSGNTSDISNAANWIQFIPNSFAYIFSLVFAIRHRIMANEILTTFAICDDKLRTQFGISFTMPNVKMRRVSILACIVTMTCGSTIGALTYLIGVNWNRIWTLLYWIAFCMPKFAGCILYLSDRAMLLLRGMNNFPVGVENLALQPQAHGHGPQYKTLNMAMGGNHHLPSMHEGKLNRLTTLATIKIRAISPLDSIQHIREVVELLQDLSVKINHCFGKQAIFSLLSAFTCVTVQLYYMLNHIKSGFTASRSEIYALASCSLLFLHGIEFWSLFTSGENVRLKWKKVINFLFFMKSKSVDDDFRNKVDDLISFMVTNPLEFNAYGLFPIDLSVLTGIASSITTYLIVLIQFKISEEQSSGYDDDTDEKSQIQYSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3W2</accession>
    <name>A0A182P3W2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SRR1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3W2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001598-RA">
        <property type="protein sequence ID" value="AEPI001598-PA"/>
        <property type="gene ID" value="AEPI001598"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001598"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="82"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001598-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="282" mass="32299" checksum="1A29CA8AD5991C87" modified="2019-01-16" version="2">MSEVDTVAKELEFKLVVTKNGKHRPKSRNKLQSSVHNIGGQVCVERAEFCQKTALTQLQQAESDLLQSEFLRECLASIAPILAGVEQLICLGLGNFLDCTIARYQLAFIRCVRSQTNLPIKGQFFDPVFTQPEVDTLHALGESILHENLEGKHAVERKTLFFLPHCPKQIVNNLLWKNWHPDRLANVVLLCNSFNTVVNNNPDRLLRVNAGYILRAVDLFQEVPLRNTFRFGDVFNDTSLHYLSDERTSEQGVWDCSNEEPWYEEEDLELISKDKVERLVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3Y2</accession>
    <name>A0A182P3Y2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3Y2"/>
    <dbReference type="STRING" id="199890.A0A182P3Y2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001618-RA">
        <property type="protein sequence ID" value="AEPI001618-PA"/>
        <property type="gene ID" value="AEPI001618"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001618"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03230">
        <property type="entry name" value="ABC_DR_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038:SF3">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 20 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="9"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="9">
        <location>
            <begin position="511"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001618-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="742" mass="81382" checksum="AD96ACA2DFF617E9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P456</accession>
    <name>A0A182P456_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Actin, cytoplasmic</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P456"/>
    <dbReference type="SMR" id="A0A182P456"/>
    <dbReference type="STRING" id="199890.A0A182P456"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001692-RA">
        <property type="protein sequence ID" value="AEPI001692-PA"/>
        <property type="gene ID" value="AEPI001692"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001692"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001692-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41549" checksum="C78D5F9E6EC26C44" modified="2016-09-07" version="1">MCDDDAGALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGNKDAYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKSNREKMTQIMFETFAAPAVYVAIQAVLSLYASGRTTGVVLDSGDGVSHTVPIYEGYALPHAILRMDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMQAAAASSSSEKSYELPDGQVITIGNERFRAPEALFQPSFLGMESTGIHETVYNSIMRCDVDIRKDLYANSVLSGGTTMYPGIADRMQKEITSLAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQTMWISKHEYDEGGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4D7</accession>
    <name>A0A182P4D7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4D7"/>
    <dbReference type="STRING" id="199890.A0A182P4D7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001773-RA">
        <property type="protein sequence ID" value="AEPI001773-PA"/>
        <property type="gene ID" value="AEPI001773"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001773"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130879" evidence="2">
        <location>
            <begin position="25"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001773-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="364" mass="40654" checksum="BB54CB14A3436122" modified="2016-09-07" version="1">MLATKWKCFCVLLVTLLAAELAGAFPYADDFPYQVHGRPVSVSGGSGVKKVLASSSKGASGEGGSDARDLRKEHAFDEAGSIGSASDAVRYHQLDNQLDGHRVLDASKGTTVDKVKHLAGENFEADKSHNRKHIKSGFTNSYHKDESGSKSSYYEDSDDHGGKQVYDNRANQRNDYADKLYSQDRRNDYLRDHYDDRASGSDLLGGHNYRRVGAFDRGNTYGHRDGYAHNDHRDQHYGSSAYGGYDHYQPAVNYHYDDLYRRRSYYDPRPAFATAPLAPAPITIYEDPRDYAPYSSAVAPPLPYPAREVRDGSSVLSRDESYHHHHQRLHEPADGAFGQRRRLIYRPSPVAAAAPPLLSGYGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4N7</accession>
    <name>A0A182P4N7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4N7"/>
    <dbReference type="STRING" id="199890.A0A182P4N7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001873-RA">
        <property type="protein sequence ID" value="AEPI001873-PA"/>
        <property type="gene ID" value="AEPI001873"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001873"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016533">
        <property type="term" value="C:protein kinase 5 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004944">
        <property type="entry name" value="CDK5_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401">
        <property type="entry name" value="CYCLIN DEPENDANT KINASE-5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03261">
        <property type="entry name" value="CDK5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001873-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="420" mass="45606" checksum="49885E4EA66E00DD" modified="2016-09-07" version="1">MGTVLSFSPRERRPIYSTHHHSAGTLSSSNSADFPLNNYSYEQLNNAKNRESGQTKPPNLIQTVPNNSHGLNMSKDDCKNNNSSSANLLGSHGNNNNNGGSNANGSANNNHSNNNNHNNNNNHSNTTSNNLLLLQQTHQNNIITGSANINNINNNISGGNSIQERNNNNNNNHSNNADSARILSEKNALEKNLKKHSLFINALSWKRLAASHGKKKLDNNKNKSANLATATSFRTPLTDTIHPLLDKNKNLQQSQSFTQTISSQQLQQQQQQPATIVLSQSGSGGQGSAGAGSQSVVGLVGASGASVGLSGQQQQQHQQVHHLHAQHGQMVVAQQQQQQQQQQAVYFTPRGPKALLALDLVRANNTNPLSQPDKLAQKLPLQLPMPLQPIVNQQQHNVPMGQQLHHGHGPRKTVIQLKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4T9</accession>
    <name>A0A182P4T9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P4T9"/>
    <dbReference type="STRING" id="199890.A0A182P4T9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001926-RA">
        <property type="protein sequence ID" value="AEPI001926-PA"/>
        <property type="gene ID" value="AEPI001926"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001926"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001926-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="411" mass="46448" checksum="0DE507B8C68DB64C" modified="2016-09-07" version="1">MVDTLARNVLLDVEQAIVLFEELAQNGETTPRGILSAVVHKLCEEELGHVLEIVRFLHRYYHSRTEHAEQRVQTLLIGIEELLRYLDALVPCIPKTGCTLLVYSLVDEAFAGGAEFLDLEESVQRVVNLKHSLEYVVRDVASAIAQPMADDDRHSLAALFEQISADLLKRLIDEAYADCSEGLAQVCDFVEHLPCIDHQIIACQVLYRRMNMDTGRLRVGATVLAYRIRKVMRYTDFARAKHAGEMKKLKLKLPEGVYAITWGYVNIAGAQFMAPKAKSERIGELKCKPAGWIETCSKTAKHEFQTYDRGKSFAIKNTHTGLFLTDVDGAFCYVETTPPDRWTVEVIKRGEDVWYKITNRRTGNSLVPAGEVRVGIDDQCDGFNLVDFNERSLVVVQKFELHRKKPACSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P576</accession>
    <name>A0A182P576_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P576"/>
    <dbReference type="STRING" id="199890.A0A182P576"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002064-RA">
        <property type="protein sequence ID" value="AEPI002064-PA"/>
        <property type="gene ID" value="AEPI002064"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002064"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000031">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.840:FF:000004">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF18">
        <property type="entry name" value="FI20035P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="329"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="551"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="683"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002064-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="716" mass="76953" checksum="B82D79E352D8D900" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5W0</accession>
    <name>A0A182P5W0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. Directly interacts with POLR2A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5W0"/>
    <dbReference type="STRING" id="199890.A0A182P5W0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002301-RA">
        <property type="protein sequence ID" value="AEPI002301-PA"/>
        <property type="gene ID" value="AEPI002301"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002301"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000073">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002301-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="150" mass="17124" checksum="4C722E985318AA95" modified="2016-09-07" version="1">MSGILFEDIFNVKDMDPEGKKFDRVSRLHCESESFKMDLILDINSWLYPLELGDKFRLVLATTLHEDGTAASMEYNAAEIEGSRADSFEYVMFGKVYRIEGDDSQTESSNRLSAYVSFGGLLMRLQGDANNLHGFEIDQHMFLLMKKLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5Y1</accession>
    <name>A0A182P5Y1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P5Y1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002322-RA">
        <property type="protein sequence ID" value="AEPI002322-PA"/>
        <property type="gene ID" value="AEPI002322"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002322"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6X2"/>
    <dbReference type="STRING" id="199890.A0A182P6X2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002672-RA">
        <property type="protein sequence ID" value="AEPI002672-PA"/>
        <property type="gene ID" value="AEPI002672"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002672"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002672-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="217" mass="24099" checksum="8C3174320C19CD1A" modified="2016-09-07" version="1">MAYKLQNLSNIHHRMSSEQLQEVFHVDHVDLVPHYELVTLTHHTNRPVLASSRRKRSIDSSQSVAKSNGLGNGGNHHVKKDLSKVRFTEKVSELTVKPAGQQQRKPVPKDVDRPGGQQVPLEAGPLVSSEPRMQQPVDDSVPLEPMDGGVSIADISEHRVEFDAFGEKVNLTLHKTEGLLRGGAHSLRMWNVRSDPNSTQGLVYEEIHDEVHALADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P743</accession>
    <name>A0A182P743_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cdc42 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P743"/>
    <dbReference type="STRING" id="199890.A0A182P743"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002745-RA">
        <property type="protein sequence ID" value="AEPI002745-PA"/>
        <property type="gene ID" value="AEPI002745"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002745"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000167">
        <property type="entry name" value="Cell division control protein 42 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002745-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="194" mass="21764" checksum="91A5B0AF921B451E" modified="2016-09-07" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCQKTPFLLVGTQIDLRDENSTLEKLAKNKQKPITLEQGEKLAKELKAVKYVECSALTQVHDKGLKNVFDEAILAALEPPEPTKKRKCRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P766</accession>
    <name>A0A182P766_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P766"/>
    <dbReference type="STRING" id="199890.A0A182P766"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002768-RA">
        <property type="protein sequence ID" value="AEPI002768-PA"/>
        <property type="gene ID" value="AEPI002768"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002768"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000010">
        <property type="entry name" value="Putative USP6 N-terminal-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000019">
        <property type="entry name" value="USP6 N-terminal like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF25">
        <property type="entry name" value="RAB-GAP TBC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="101"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="841"/>
            <end position="1272"/>
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            <dbReference type="Proteomes" id="UP000075885"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Epiroticus2</strain>
        </source>
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                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
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</entry>
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            <taxon>Pterygota</taxon>
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            <taxon>Diptera</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Gujja S."/>
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                <person name="Imamovic A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">Epiroticus2</strain>
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                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="7">Epiroticus2</strain>
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        <property type="gene ID" value="AEPI002935"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SAM_liprin-beta1_2_repeat1"/>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
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    </dbReference>
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        <property type="entry name" value="SAM/pointed_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SAM/Pointed domain"/>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="990" mass="107895" checksum="33F2D923B739CE1F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7R0</accession>
    <name>A0A182P7R0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7R0"/>
    <dbReference type="STRING" id="199890.A0A182P7R0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002963-RA">
        <property type="protein sequence ID" value="AEPI002963-PA"/>
        <property type="gene ID" value="AEPI002963"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002963"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="86"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002963-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="250" mass="27322" checksum="3483F20A9C734DC2" modified="2016-09-07" version="1">MVVLEGANVTLTCAATGVPEPTIVWKRKGEKSLTAVEDSGITSHEGAMLHIHNIQRQNAGPYLCIASNGVPPTVSKRIIVTVNFQPIIHLPARDYYADLGGRVVLECRSEAQPNSINYWMKGRGEIILQGGTYNSTLEDHVFKVSMRIAIRLAKESDFGVYKCVAKNSLGTTERSVTVKRRASKTKQVQSNQVIQQSNYLGSTTFIKNYTDNKINEILLTASAASSSASCITFGWFLISIAVGASVWALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7U5</accession>
    <name>A0A182P7U5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="AlphaFoldDB" id="A0A182P7U5"/>
    <dbReference type="STRING" id="199890.A0A182P7U5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002998-RA">
        <property type="protein sequence ID" value="AEPI002998-PA"/>
        <property type="gene ID" value="AEPI002998"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002998"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.80:FF:000009">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000007">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="15">
        <location>
            <begin position="264"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="458"/>
            <end position="461"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002998-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="537" mass="59417" checksum="3EAD067159ADA845" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P890</accession>
    <name>A0A182P890_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4794 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P890"/>
    <dbReference type="STRING" id="199890.A0A182P890"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003143-RA">
        <property type="protein sequence ID" value="AEPI003143-PA"/>
        <property type="gene ID" value="AEPI003143"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003143"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130938" description="DUF4794 domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003143-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27499" checksum="C2D63ED1B2CA0B9B" modified="2016-09-07" version="1">MERRWKFTREPLLSHCCILALILLAFQQTSTVQGAPRRNTPKAFDSEEAYYETDGSYEEDEDGLHHGTGEIHHGASNPHDDNESVEIEYEEHDGHHLPTNGVAESDESGEDHDDSFNNAELLAQLGIHQKLLGYGKKKGKHYRPPVTIAVPYPVHIERKVPVFIEKKVPVIVEKKVEVPVDRPVEVPVPVKVPVHEKEVVHVPKPIVFNVDRPYPVFVHRTVFVEKYRPFKVLIKSRTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8P7</accession>
    <name>A0A182P8P7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P8P7"/>
    <dbReference type="STRING" id="199890.A0A182P8P7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003301-RA">
        <property type="protein sequence ID" value="AEPI003301-PA"/>
        <property type="gene ID" value="AEPI003301"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003301"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003301-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="300" mass="33612" checksum="1DE157151D11D2F5" modified="2016-09-07" version="1">MGDKVLPDASKSDDEQFEDAQSRDDFNERTVDEVIAKVTGLAVRKPPDSDAEEFVDCVNHSGAEATQPSQKKQSPAVEEEGESGGQKCTTQAETTPPEDDLIDEDSQRDYECGLSEEEKEANKTKADVLKQQGNELFKAGEHIRSVELYTQALRLCPLDCNEARAILYANRAAAKTKVDRKQSALEDCTKALEYNPQYLKALLRRANLFEETDKLDESLEDYRKVLELDPGNGEARAAQVRLPPKIAERNERLKEEMMGKLKDLGNMILRPFGLSTQNFEMKQDPQTGSYSINFNQGGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P937</accession>
    <name>A0A182P937_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P937"/>
    <dbReference type="STRING" id="199890.A0A182P937"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003441-RA">
        <property type="protein sequence ID" value="AEPI003441-PA"/>
        <property type="gene ID" value="AEPI003441"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003441"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="10">
        <location>
            <begin position="14"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003441-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="360" mass="38746" checksum="7E84362B74BAA889" modified="2016-09-07" version="1">MASKNDNLTAVLYGIEDLRLEQRPIPVPKDDEVLLEMDVVGICGSDVHYLVRGRIGDFIVKKPMVIGHEASGIVSKVGSKVKNLQVGDRVAIEPGYGCRTCEYCKSGAYNLCADMIFCATPPYDGNLTRYFAHPADFCYKLPDHVTMEEGALLEPLSVGVHACRRANVGLGSQVLILGAGPIGLVTLIVAKSMGASKVLVTDLLQNRLDVAKELGADETLVIPKDVEEAELVKIIHERMGGAPDKTIDCSGAEATARLTILATKAGGVGVMVGMGAPEVKLPLVNALAREVDIRGVFRYCNDYPVALSLVSSGKVNVKRLITHHFNIEDTAKAFHTTRHGVDGAIKVMIHVQPKDKNNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9X2</accession>
    <name>A0A182P9X2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P9X2"/>
    <dbReference type="STRING" id="199890.A0A182P9X2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003726-RA">
        <property type="protein sequence ID" value="AEPI003726-PA"/>
        <property type="gene ID" value="AEPI003726"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003726"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045323">
        <property type="entry name" value="CCDC34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025259">
        <property type="entry name" value="CCDC34/181"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23247:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23247">
        <property type="entry name" value="NY-REN-41 ANTIGEN L15 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13904">
        <property type="entry name" value="CCDC34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="3">
        <location>
            <begin position="138"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003726-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="310" mass="35842" checksum="D1706B8A8A686631" modified="2016-09-07" version="1">KKAIQVSKIWHSSDSDTEDEANDERDFKVVHELSYAMSNLSLSNNELKDSVCYSESNDTVGGNDANTILEQKDDEYGADHNSDTSGTLDVSSEGEQDERQPCSTDRGGGDADLNLDTDTSSQIIKVNVAFKKRDRDPEAYKKWLKSKNEEIRKNREKEMMTKLLYQRQKELDEQTRKEENKKKIQEWMERKKQGSCKQNINGNPVNNPNSSRHSPPDHLLCDPDAKYKSWLHQVRKREEERRIRDQAVKELEKKIQEEKKKMSEEVYQGWLKGAKHKPKPVPLNQGPHTLRGTVSSIFINPEPWKSNVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA14</accession>
    <name>A0A182PA14_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PA14"/>
    <dbReference type="STRING" id="199890.A0A182PA14"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003768-RA">
        <property type="protein sequence ID" value="AEPI003768-PA"/>
        <property type="gene ID" value="AEPI003768"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003768"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001386">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="105"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003768-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="251" mass="28674" checksum="564BCCB3357983E3" modified="2016-09-07" version="1">MVPTKPRNLSVLEITSTTIRISWLEPEKRNGVIHGYRVYYVYQNQTLLHLPILKNDASLNSVFYYTLANLKPFTDYRIIVTAFTLKYDGEPSEVSLRTDVGGPSPPKVLNLTCHSLDALVFSWQIPRVYHSSIDFYIVNYRNLEYDVTHEIRITANTSFFETSMVIPNLTTNSAYEVKVRGATVSTVNPKKVVLGTYCEPIKITLRENCEQYQPPKLRHNPYVDQELVILAGTVIGCFGLLLIILAIVLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA42</accession>
    <name>A0A182PA42_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline O-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.6" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PA42"/>
    <dbReference type="STRING" id="199890.A0A182PA42"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003796-RA">
        <property type="protein sequence ID" value="AEPI003796-PA"/>
        <property type="gene ID" value="AEPI003796"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003796"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004102">
        <property type="term" value="F:choline O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000001">
        <property type="entry name" value="Carnitine O-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000011">
        <property type="entry name" value="Choline O-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF14">
        <property type="entry name" value="CHOLINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003796-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="636" mass="71427" checksum="33887E2519633CB5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBJ7</accession>
    <name>A0A182PBJ7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBJ7"/>
    <dbReference type="STRING" id="199890.A0A182PBJ7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004302-RA">
        <property type="protein sequence ID" value="AEPI004302-PA"/>
        <property type="gene ID" value="AEPI004302"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004302"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF62">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="113"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="440"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004302-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="74341" checksum="EA8DEFAECC4DA2BE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBX0</accession>
    <name>A0A182PBX0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Transient receptor ion channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell projection</location>
            <location evidence="14">Rhabdomere membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PBX0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004426-RA">
        <property type="protein sequence ID" value="AEPI004426-PA"/>
        <property type="gene ID" value="AEPI004426"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004426"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033583">
        <property type="term" value="C:rhabdomere membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000221">
        <property type="entry name" value="Transient receptor potential-gamma protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00870">
        <property type="entry name" value="trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF47">
        <property type="entry name" value="TRANSIENT-RECEPTOR-POTENTIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="19">
        <location>
            <begin position="192"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="907"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="945"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="978"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="952"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1062"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1190"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1217"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1263"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1283"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004426-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1318" mass="146582" checksum="AC686628D87A6D21" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC69</accession>
    <name>A0A182PC69_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF38">
        <property type="entry name" value="FI23916P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="42"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="148"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="250"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004524-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="490" mass="55358" checksum="DE809B706AE05972" modified="2025-10-08" version="2">MPQSSVSVSKEQRNKQEAVESPVDDYDEDYDDDEDVPSQEKPEISDNALLGTNLLTKDYIEQARESEQVTLRCDVSNPSTNTIIFWYYNNKPIFQHQNRLISDERYELNPDFSLQIDNVQLSDEGVYTCQLLPQKMTVKIELQLLTPPRDVHIMHGSKTVNETMEVHQRDRKFVLLCSAGGHPSPLITWAYRGRHLDEENSHHIGIKLRKEFLEIHEVKAQHAGDYECMAQNGIGNPISQTVTVVVKGSPIIHKHSSYINTAIGENVEMVCLYDSNPTPRKIQWLRNDEIVQPAAGQTTITNDHHNHHNRTRLSIKNVQQKDLQAYYCKIENELGEAVSKTILGLVPGGAHLVHSNVSDGLLHTWWKIHSIQQISEMQLLYRGENTKYTPVNAEISSHDQNPDGYTWTIRKSVRLPEGEWYVTARARNTEGWSSAESLPHQFQIRDAMDNIQVASIGGGGASGAHRTLPALSVGGVVLLLLLPLVKSLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCG3</accession>
    <name>A0A182PCG3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="8">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor 4 homolog</fullName>
            <shortName evidence="8">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A182PCG3"/>
    <dbReference type="STRING" id="199890.A0A182PCG3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004618-RA">
        <property type="protein sequence ID" value="AEPI004618-PA"/>
        <property type="gene ID" value="AEPI004618"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004618"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="49"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="123"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="177"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004618-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="650" mass="72299" checksum="6480DAE77232415A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDB0</accession>
    <name>A0A182PDB0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDB0"/>
    <dbReference type="STRING" id="199890.A0A182PDB0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004915-RA">
        <property type="protein sequence ID" value="AEPI004915-PA"/>
        <property type="gene ID" value="AEPI004915"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004915"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051121">
        <property type="entry name" value="FAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796:SF4">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="129"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004915-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="339" mass="36628" checksum="D102BAE3BEAC049D" modified="2016-09-07" version="1">MTTIASIALRTGTTSARLSSTLVGAFGDKPTSWINPHNVSRRYLSNSSPQAMRFVQFRSAATGEKQRLGVLSEDGTQVSDISDRYEGDLITLIRSGASLDEVKASIAKAAAPVKVDSVELLAPVTNPQKILCVGLNYSGHCEEQNKPIPKEPMFFSKYATTIVGPYDNVIAHKISDQIDWEVELAVIIGKKAKSVAKANAMDYVFGYTVAQDISARDWQKQRNGGQFLIGKSMDTFCPLGPAAVHKSLVKDPHQLAIKCSVNGVEKQNGSTSELIFRIDDIIERVTESITLLPGDVILTGTPAGVGMHRKPAEFLKPGDVIDSEIEGLGKIKNKVVADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDB8</accession>
    <name>A0A182PDB8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COMM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDB8"/>
    <dbReference type="STRING" id="199890.A0A182PDB8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004923-RA">
        <property type="protein sequence ID" value="AEPI004923-PA"/>
        <property type="gene ID" value="AEPI004923"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004923"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="117"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004923-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="178" mass="20384" checksum="DBADA0E28CD09C16" modified="2016-09-07" version="1">MHEIIIQTVDEKDFTEVIFLLIDYIVEVPRSQQCRDRLAQLLGLSASSDELKRTLKQFETLVLKYCVGELDEAGLRSHLVTLPSSRQDQVLEIVNLRRLQVARRLIDEVNRREGGVPLVESFDWNLSWVMGSSSLASLRKQLCTMVFACRDANSISFEMNRKQVEELISELESVIVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDN1</accession>
    <name>A0A182PDN1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDN1"/>
    <dbReference type="STRING" id="199890.A0A182PDN1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005036-RA">
        <property type="protein sequence ID" value="AEPI005036-PA"/>
        <property type="gene ID" value="AEPI005036"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005036"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000012">
        <property type="entry name" value="Putative DE-cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005036-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="247" mass="27342" checksum="7A7235305B0B7521" modified="2016-09-07" version="1">MLGGAAVNLDYLGSLFNWTYVPQDKGFTGCLRNLTINEKTYDLGLPSLAKNADPGCQRSVAVAVSFGIDSYFLIAIIACIVVLLVLLLAVVVHKKHQDGWHEKDMDDIRETIINYEEEGGGERDAEYDLTVLQGPPIYLDKPYGSELRQKEANTEVPDIGAFLTDKKDACDKDADAYPIDDVRHYAYEGDGNSTGSLSSLASCTDEGDLKFNYLSNFGPRFRKLADMYGEEPSDTDSNVDDEEGWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDT2</accession>
    <name>A0A182PDT2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger CCHC domain-containing protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TRAMP-like complex RNA-binding factor ZCCHC7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Larimer J."/>
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                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDZ5"/>
    <dbReference type="STRING" id="199890.A0A182PDZ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005150-RA">
        <property type="protein sequence ID" value="AEPI005150-PA"/>
        <property type="gene ID" value="AEPI005150"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005150"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131196" description="UDP-glycosyltransferases domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005150-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="60178" checksum="5DA6AC86BF6E14C3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE99</accession>
    <name>A0A182PE99_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PE99"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005254-RA">
        <property type="protein sequence ID" value="AEPI005254-PA"/>
        <property type="gene ID" value="AEPI005254"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005254"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005254-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="480" mass="53426" checksum="65425EFFE90A1108" modified="2016-09-07" version="1">MGSRNPSDHPIFWCDDLKRLERKRIADESLRDWKNRKLIERRSRAKEQSHFPLFQYREVMERYSPWGRKGGGAPNDTIRMRNIQLQGLYPETKNDLRNPVPVGRARPGGIGAGGGGAPIRSASGQIVTGLTDDPIISFNDANRYHVDNELRYKTSPAQKQTYRAELDRIVAEKENRARKTRSSELAGDGAPGVGGAVGRPNGGPWGKPGPGGKPWRPPKNVGHNFMKSMGWTNKETLQDLDLELVNRMQRQLEEENRFLKRFSNCCSRCVCQCISNTLEQAGPAAGGGSAGAGGARDAIKYHQSPPATAPQPLPPAPPTDRRVARLCNQQSQQQQQQSPQQQPSQQQQQAGNGGGRRNGGRVPPTRNCMITGGVELVPLLAKRRSQPRPISLGTTDVTKIDKYTANGSLARRTDDGYLTDLCNQMSQKQRKVETVRAMEFETSRQHFETWSSFWGRPGHGAPLPNKNKLNLDNLLYKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PED8</accession>
    <name>A0A182PED8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PED8"/>
    <dbReference type="STRING" id="199890.A0A182PED8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005293-RA">
        <property type="protein sequence ID" value="AEPI005293-PA"/>
        <property type="gene ID" value="AEPI005293"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005293"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005293-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="140" mass="16327" checksum="D49AA39D48DC7C0E" modified="2016-09-07" version="1">MRSNYIMQQHSRVHHEPRLVKEFSCQHEGCHFIARNAADARRHLLAHSCERNFACSEPGCNYRGKSLAQLRSDHTRIHAGTLLDHRKSEQKRKIGKRTARERATTDDSSPQRFVCFRKRPQLQRISCRGAHCDLLPIDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEQ3</accession>
    <name>A0A182PEQ3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC27 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEQ3"/>
    <dbReference type="STRING" id="199890.A0A182PEQ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005408-RA">
        <property type="protein sequence ID" value="AEPI005408-PA"/>
        <property type="gene ID" value="AEPI005408"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005408"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005408-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="786" mass="90112" checksum="41740002A72302F2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF25</accession>
    <name>A0A182PF25_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="11">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182PF25"/>
    <dbReference type="STRING" id="199890.A0A182PF25"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005530-RA">
        <property type="protein sequence ID" value="AEPI005530-PA"/>
        <property type="gene ID" value="AEPI005530"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005530"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000165">
        <property type="entry name" value="3-ketodihydrosphingosine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005530-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="327" mass="36041" checksum="015A295007CF60D1" modified="2016-09-07" version="1">MNHSTEIILTIAGIVLVHGLIFYFLTRKSRLIKGKHVVVTGGSSGIGLWAAIECVRLGAHVTIIARNVSLLEKAKEELEKRRVRDTQLIQFRSLDLSKSYDAVKSTLDELERTVGSIYMLVNCAGMAICGTVEDTSIEDARKLMDVNYFATYYPTRHVLPKMKEAGDGIIVITASQAALMGIYGYGAYAASKFALRGLAETIAMEAKHRGVSVTLALPADTDTPGFENENRSKPEETKIISGSGGLAKPEDVGRRIVQDALKGSFFSIMGLESWVLSILCVGMAPWRGPLLCFVQFYLLGPLRLIGLVLQWNFQRIIKNCAKQRQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFE1</accession>
    <name>A0A182PFE1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="STRING" id="199890.A0A182PFE1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005647-RA">
        <property type="protein sequence ID" value="AEPI005647-PA"/>
        <property type="gene ID" value="AEPI005647"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005647"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000008">
        <property type="entry name" value="Adenylate cyclase type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF8">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
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            <end position="127"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <end position="157"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="187"/>
            <end position="207"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="270"/>
            <end position="293"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1189"/>
            <end position="1208"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <end position="1235"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <end position="1293"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1305"/>
            <end position="1324"/>
        </location>
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        <location>
            <begin position="392"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="1465"/>
            <end position="1602"/>
        </location>
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        </location>
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            <end position="973"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005647-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1663" mass="180474" checksum="DAF9C6383B9C6BEA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFJ3</accession>
    <name>A0A182PFJ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
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            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PFJ3"/>
    <dbReference type="STRING" id="199890.A0A182PFJ3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005700-RA">
        <property type="protein sequence ID" value="AEPI005700-PA"/>
        <property type="gene ID" value="AEPI005700"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005700"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="44"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005700-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="218" mass="26012" checksum="25AFFB602DB921EF" modified="2016-09-07" version="1">MSTTSYREFLRNFTMLAFSHPKPTVAIPDCREFFIEQNGQSQKLEIICMRKADLSKELIKWAYDLATRNLMSKYRSYGLRWPKKTMEKELYMWWARYLIVYDPSNYVPCGYIMFCFEYSTEHTIVHIVGIHVEGMYQNKGIGTQLMKTVEVLARRFGVQLLTIAVAKKDLDMKRFLYRMGFVHEYTSTWLKGYEMLKMPTKYYKTMVDWCCQGTRDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PG86</accession>
    <name>A0A182PG86_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PG86"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005945-RA">
        <property type="protein sequence ID" value="AEPI005945-PA"/>
        <property type="gene ID" value="AEPI005945"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005945"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005945-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="185" mass="19548" checksum="BC662C8CFCEF7C63" modified="2016-09-07" version="1">MEMFVAKVHTKSHWSSPLGLKVCEPIGPASADVDASPKFADVVYPLFGYCWYWLCQKLYVSWFGTYDSGLWDVCGVIGGDGVVMMEEFDPSGVRLPADGPFPSPPPTPTPTPPTPPTPPTPPTPPTPPPPPTPPPTPAELSDCPSRITLIGGLTEVDGVIGSIGDALLWLSPSGPLLWLGPAGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGH4</accession>
    <name>A0A182PGH4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGH4"/>
    <dbReference type="STRING" id="199890.A0A182PGH4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006033-RA">
        <property type="protein sequence ID" value="AEPI006033-PA"/>
        <property type="gene ID" value="AEPI006033"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006033"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF69">
        <property type="entry name" value="SI:CH73-59F11.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="150"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006033-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="419" mass="48189" checksum="94D7307A6A7FCD4D" modified="2016-09-07" version="1">MNKTLMLKEEVVLALINTIRRKPILWKQNAPGYRDLTAQQQAWQSVANQYGVPVEQLKLKWRMLRTQFRSNLSKIRYKRMEGTGELNYQPTWFAFEAMKFLRDIPELNAPGTTTNATTTATSQADVSLPTGEPTLHGYPEDIDTHEICLELINRIKHKPILWDKKHPEYSNSSRHIEEWREIADSMQLPVADIKRKWQHLRVQFRNNLKNIKIRSTPGCKYKPTWFAFDAMQFVRKNVTIDLKKLADKNPEMKVKHLVPVPVPKPSTTSQTPSVKPLVREYKRRNLSPIRSSQEKVQRIQPCTSTTQQATVTSSPGSAPAPPAAIRPVSYVTNGNVEPFIIRTFRNLSKITDKIAQTNASPYKGLLDHLAAVLERKRKHDFVEIEGVLLKCLGELQKFPNAKENVRKTMVMMEDDEESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI33</accession>
    <name>A0A182PI33_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dihydropyrimidine dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="17">DHPDHase</shortName>
            <shortName evidence="17">DPD</shortName>
            <ecNumber evidence="17">1.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dihydrothymine dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Dihydrouracil dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>5,6-dihydrouracil + NADP(+) = uracil + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the dihydropyrimidine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.2" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A182PI33"/>
    <dbReference type="STRING" id="199890.A0A182PI33"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006595-RA">
        <property type="protein sequence ID" value="AEPI006595-PA"/>
        <property type="gene ID" value="AEPI006595"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006595"/>
    <dbReference type="UniPathway" id="UPA00131"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017113">
        <property type="term" value="F:dihydropyrimidine dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002058">
        <property type="term" value="F:uracil binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019483">
        <property type="term" value="P:beta-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02940">
        <property type="entry name" value="DHPD_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000007">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000027">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000023">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000061">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073:SF2">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14697">
        <property type="entry name" value="Fer4_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 17" id="KW-0288">FMN</keyword>
    <keyword evidence="14 17" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="18">
        <location>
            <begin position="987"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="18">
        <location>
            <begin position="1021"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006595-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1074" mass="116183" checksum="770FEE51CC481ED1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIL1</accession>
    <name>A0A182PIL1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PIL1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006773-RA">
        <property type="protein sequence ID" value="AEPI006773-PA"/>
        <property type="gene ID" value="AEPI006773"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006773"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF134">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006773-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="388" mass="45730" checksum="19128E638FF863FC" modified="2016-09-07" version="1">MKHLYFYYLLGVMNIRYDKRKDLFTSSKLSTALKLVFHLIVPNVVLLTISIIGKTGILLTIPSVHMVVFAMRIVWTMLTMNITMLLNYLFTSKNQMALLNECLTCLRDAQTASVDESIAVNSSFRRSKIVLGIFLLHYTNYEINQYTYVLLYDEKWPELTFYILFYFLEMVTVVNALYYAAVLDIVHRTVQLDRDRLANCLQQNAKNDPFELDDPYWWRTIEHFYQRVLTINRRKRDYKRAFQLQLIMIALNTFIASFAIFYVNLNSMLLYAHNNVLEKYKRVTECLGFFPQLGALLLICYHAYKLENEQQSLMQLIMQTQSKLTKCTANLKRGDIFNSRIIILQSQLKISPYNMLNIDLEYFFGIVAAIVTYLVVLLQFRIFENSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKM8</accession>
    <name>A0A182PKM8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tumor necrosis factor alpha-induced protein 8-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKM8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007495-RA">
        <property type="protein sequence ID" value="AEPI007495-PA"/>
        <property type="gene ID" value="AEPI007495"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007495"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.160:FF:000001">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.160">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008477">
        <property type="entry name" value="TNFAIP8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038355">
        <property type="entry name" value="TNFAIP8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757:SF1">
        <property type="entry name" value="PROTEIN SALIVARY GLANDS MARRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757">
        <property type="entry name" value="TUMOR NECROSIS FACTOR INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05527">
        <property type="entry name" value="TNFAIP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007495-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24867" checksum="FE1C4062F796B761" modified="2016-09-07" version="1">MYNMSAASILELQTWIVYQHIAAECANCLFMTDNAFKAKDIGLRAQKKILSRMASKNVAKVFIDGTTASLLDNVYRLVKVHTGSKKDAERLVKNIIKIVIKIAVLHRNGQLNADELRQADRFRSKFQTLQMAILSFYEVDYSFDLNYLQKSLADCRSLLRSCVVRHLTDKSLGRIDEVFDTFADSALLETAFRQDSPYREIMDKIVVDLNKAMENGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLB7</accession>
    <name>A0A182PLB7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mucin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLB7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007735-RA">
        <property type="protein sequence ID" value="AEPI007735-PA"/>
        <property type="gene ID" value="AEPI007735"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007735"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007735-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="34994" checksum="A66B12C88E4448E3" modified="2016-09-07" version="1">MLIFLLVSASLVCAEPPVHGGYGHGHGHGGGGGGGGYDDGGYIAVSPGHQTSEGLHVDHSLLHKVKEALLEHENSGSHGGGGYSGSLSTSYGPPSGSYGPPSPVYGVPSYSGHGHVKTTGIELGHVQQGIQVAEYYKAAHGPSYSSYSAPSYSSHSSSSSYSAPSYSSHSSFTPSHGYSSGGSSYSSYSAPSVSSHYSAPSVSSHYSAPSVSSHYSAPSVSSHYSAPSVSSHYSAPSHSSFSGLSSSYGAPSLSSSYGAPAVSSHYSAPSFSSHSSGSYSSHGSSHSSGPSFVAIPSSSYGVPSFGSSGHHHRPSHSSSHSYSSYRPPSSSYGPPRPTYGVPHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLB8</accession>
    <name>A0A182PLB8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLB8"/>
    <dbReference type="STRING" id="199890.A0A182PLB8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007736-RA">
        <property type="protein sequence ID" value="AEPI007736-PA"/>
        <property type="gene ID" value="AEPI007736"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007736"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01824">
        <property type="entry name" value="Phospholipase_B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035547">
        <property type="entry name" value="Phospholipase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131619" description="SGNH hydrolase-type esterase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007736-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47972" checksum="F933C60543A678A3" modified="2016-09-07" version="1">MILRCSFACLLVMYALPAASGQRTVRQDRYVDITDQRTMLDSAGMRPMFHLLRSWMFNVVGKTGQRKSGSFLQQPIPPEVPFPCDVSLGRSAKVPTNVHKLRPGDINVIAAMGDSLTAATGAAASNFFGLYQENRGLAWSIGGQWDWRNVTTLPNILKVFNPKLVGYSLGDAYPFHSDSQFNLAEIGAVSYDIPHMARALVQRIKRDPRVDWKRDWKLVTIAIGGNDICSFVCTMRYPDQLPAKHRLRMQRTLRYLRDNMPRTFVNLVSVPSVAKVVMLQGKPFACESLHHGECSCWIGKLYNQSEASRARWGRIQEEMIRVEQEVARSAEFRGLDEFAVVYQPWSLNVTMKMNGKDVDYTLLSYDCFHMSQKGNAYAGTALWNNMLEPIGKKSPSWRPLLKNFKCPTKESPYLFTYDNSVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLG5</accession>
    <name>A0A182PLG5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">28S ribosomal protein S24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLG5"/>
    <dbReference type="STRING" id="199890.A0A182PLG5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007785-RA">
        <property type="protein sequence ID" value="AEPI007785-PA"/>
        <property type="gene ID" value="AEPI007785"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007785"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026146">
        <property type="entry name" value="Ribosomal_uS3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14955">
        <property type="entry name" value="MRP-S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007785-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18513" checksum="8ABADA8D1C963A1A" modified="2016-09-07" version="1">MLPSAKLVSRLVLAKRCVHTTAVAGKSQSGRYKISPKGDRPLTYEMANPPHQIAHRKAWNSWNTSNLEGELRPSQTMLEDDFIRRFMAGTWHGMVLSEVIIKRQHNHVRIAAIINRSIPARKMYFLIGYCEELLSYWLQCPVTLELQTTDDRKDVIFKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLY2</accession>
    <name>A0A182PLY2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLY2"/>
    <dbReference type="STRING" id="199890.A0A182PLY2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007954-RA">
        <property type="protein sequence ID" value="AEPI007954-PA"/>
        <property type="gene ID" value="AEPI007954"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007954"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="9">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007954-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="49651" checksum="126185A944A5F02D" modified="2016-09-07" version="1">MAIREQYETVCRFCLNQDQDQLIPLRAITACSISLEDLERFTGIEVVEEESKLYVSCGDCHLTLLSSLSFRNTCLANDKYFKELCLSAEEYIDSPCDEGKDVALEVPQETVSEIEFVVLNNRKGRNVTIKEETLPTIQTRSALKREQADSVNNDYCANGVEIGEPFSSDDEQDGQNQTTPRVILDKDKLFAESMRLIREAQQRSEHEEERVDTEGDDSDSNNAPLHIKRRSRTARDQLCDICGKVVHKLSDHITIHTKELRYACPHCPVRMANHGNLYRHVQAVHLKKVIKTCEICGKGFTSTGSHKSHMQAEHGIGQTYECKLCPKTFRHPGNYRVHFIRCHSEERKFTCAICGKQFKEKRDHRNHQRVHSDAKPFICSQCPKGFKSDYARKTHELTHSGAVFKCAHCKKSYRYKCLLSIHMKKVHSEIKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM00</accession>
    <name>A0A182PM00_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PM00"/>
    <dbReference type="STRING" id="199890.A0A182PM00"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007972-RA">
        <property type="protein sequence ID" value="AEPI007972-PA"/>
        <property type="gene ID" value="AEPI007972"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007972"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06866">
        <property type="entry name" value="PX_SNX8_Mvp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035704">
        <property type="entry name" value="SNX8/Mvp1_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46571">
        <property type="entry name" value="SORTING NEXIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46571:SF1">
        <property type="entry name" value="SORTING NEXIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007972-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="364" mass="41764" checksum="98411B5B2155FD1B" modified="2016-09-07" version="1">MAAINGDDSTERELNESPVSVQIVPEKKGLFLKHSEYEIKLKGIEKTVRRRYKDFVTLHRYLAEKYPYRLLPALPPKQLMLDSLLEERRRGLQTWLTIVALHPVLGGSPIVSTFLRDTTTDHQYRLRVAYEKQMDELERLRPDATLPVVDVDTLADSRTRLRRVQCSVGRMKQLFDRRLCHSRRQTAECAEIDRILQGPDLRDVFNEDATFEDMSASERLIAKQVERYVQVQQRAVTERLDVLLEVLHAHSELCERIERGIIAEQQRAVVKSPGVGAGRGREKVIARSINQSDAMALPADGNGSATRRSAFAFSCAQTETLLAERYLQSLPSILLSYAHEEQQHHQKMSKIWHRLVVSESSRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMD7</accession>
    <name>A0A182PMD7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMD7"/>
    <dbReference type="STRING" id="199890.A0A182PMD7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008110-RA">
        <property type="protein sequence ID" value="AEPI008110-PA"/>
        <property type="gene ID" value="AEPI008110"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008110"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF111">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008110-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="559" mass="61286" checksum="8A1BABE7CDC71128" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMG0</accession>
    <name>A0A182PMG0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PMG0"/>
    <dbReference type="STRING" id="199890.A0A182PMG0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008133-RA">
        <property type="protein sequence ID" value="AEPI008133-PA"/>
        <property type="gene ID" value="AEPI008133"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008133"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008133-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="453" mass="52513" checksum="0DB85FB424004CCE" modified="2016-09-07" version="1">MRKSIHRRGDVILQEKPFACVLDPRYRDSRCDRCFKEAKVKKCSNCLYVRYCGRACQKEAWSDHKEECEKLKLLPPGLVVPSAALMIARIVRRLLKGGDTYKGYYTSKLYRKFSDLMPHEENIRADAKRMDHFATLYVVLQRLLDEASRPTKAELLRIYGKMCINTFNILDTEMNTIGTGMYIGASIIDHSCRPNVIVSFDGETLKMRLLEDYPEQELNFRKLFISYIDLIDTTEVRRDQLAERYYFDCACERCRDEQEQKRMNAAACPNKSCYEPLDMNDPQLERCPTCGSVVTHSDRETFNEISSFTRDHLAQMKNVAYLDVSRLCLQKQERVLHRYNVHHIKTLDNAMESALNMEKWTEATGYGLRLLDGFRQYYSPYHPMLGLTYLKVGKLQLYQCQFAEALHNLQQAGKIVRVTHGEQDDLYKRVLVPLLCDAAQGDLGHLAIAADEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMM1</accession>
    <name>A0A182PMM1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PMM1"/>
    <dbReference type="STRING" id="199890.A0A182PMM1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008195-RA">
        <property type="protein sequence ID" value="AEPI008195-PA"/>
        <property type="gene ID" value="AEPI008195"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008195"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF213">
        <property type="entry name" value="3'-5' RNA HELICASE YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="722"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008195-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1115" mass="126767" checksum="71C787AE0BC3F99C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNC6</accession>
    <name>A0A182PNC6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNC6"/>
    <dbReference type="STRING" id="199890.A0A182PNC6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008453-RA">
        <property type="protein sequence ID" value="AEPI008453-PA"/>
        <property type="gene ID" value="AEPI008453"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008453"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SERINE-ENRICHED PROTEIN"/>
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        <property type="entry name" value="POZ domain"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="43"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
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            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008453-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="448" mass="50872" checksum="87EC56792AE4D365" modified="2016-09-07" version="1">MRPSSPLLDSVRDQFEDYDQLAKDFTRVFLNSEPSCLQNAQLFDVVFLVGQSKQRARFIGVRAILGVRSRVFQEMLYGIQTGFGSPQVPVAELLARPAPTLLSPQNQRPKSSNFLQVPDIESPRPKSVPSSPMVKRAFSRLGTITAGWGRSIRKQHTQLNAEDKKKWASSQDCSDKDGKETSSKSKANAGQLAVPRLSVCADAQKVDRAKLAQTEFTIIEFDPDTFRVLLDYLHTGSCPLTCTSIPGLICAAEHYDLPELLQACFHHAKQFLRIDVVCTMLTALENYYWRYTSASELVNMILAFVETRAYALFQNADFLTLSESMVQMIMCRNLEIPEVRKFEAMLAWAKYKVKSKASAKTDAKVEFRCIMERLARDLKLHRISPQELIKIVLPSKAIKNERILETLMYQANSGMYRIQDSYLEACQQRLQKQDSRYSEWGESFDCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNF1</accession>
    <name>A0A182PNF1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartyl/asparaginy/proline hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PNF1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008478-RA">
        <property type="protein sequence ID" value="AEPI008478-PA"/>
        <property type="gene ID" value="AEPI008478"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008478"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062101">
        <property type="term" value="F:peptidyl-aspartic acid 3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039038">
        <property type="entry name" value="ASPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12366:SF29">
        <property type="entry name" value="ASPARTYL BETA-HYDROXYLASE, ISOFORM L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12366">
        <property type="entry name" value="ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="4">
        <location>
            <begin position="1305"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="800"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="848"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
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        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
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        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="881"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="988"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008478-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1470" mass="165885" checksum="1CF5B3014A4AB379" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNH9</accession>
    <name>A0A182PNH9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PNH9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008506-RA">
        <property type="protein sequence ID" value="AEPI008506-PA"/>
        <property type="gene ID" value="AEPI008506"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008506"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNZ7</accession>
    <name>A0A182PNZ7_9DIPT</name>
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        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
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    <comment type="catalytic activity">
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            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
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        </reaction>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <proteinExistence type="inferred from homology"/>
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    </evidence>
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    <sequence length="493" mass="56505" checksum="CE73709BD1428F5F" modified="2016-09-07" version="1">MMQQKCPNIPAVFADADVFITGGTGFMGKVLIEKLLRSCPHIARVFVLMRAKRGKSLEERLKEITDGVLFDVIKSENPAALRKIHPIEGDCTQLKLGMSPESIELIKDVQFVFHVAASVRFNDPLKDAILINTRSTREVLDWAKTLRKLRAAVHISTTYCNPELKLVEEKIYPPKMDWREAIRMAEMFDSAVLETVKEKLTQFAPNTYTYTKGLAEQICYEYRNDIPLVVFRPSIVTNSETEPLTGWVDNFNGPIGLLLGCASGVVRAGLLDLDKRINCIPVDVSIKAIIVAAWKRATIDERGALPVYNSAAEPEKTVNYGSMLYDGKVLFDRTPLNNMLWAPGGITTTNQYCFYLVFFCCQLLPALIVDALLHIVGKTPFLLKLNRKIFDAQISLRYFMNNEWVFRNENFKELEYTIMDDDRKDFSTKYFVLGMMEYYEAAILGGRRYLLKDPDESIEHALQKYKRLRVLNYVLKFALAFVTMYYIYNRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP96</accession>
    <name>A0A182PP96_9DIPT</name>
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        <recommendedName>
            <fullName evidence="11">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
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    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP96"/>
    <dbReference type="STRING" id="199890.A0A182PP96"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008775-RA">
        <property type="protein sequence ID" value="AEPI008775-PA"/>
        <property type="gene ID" value="AEPI008775"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008775"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF31">
        <property type="entry name" value="IONOTROPIC RECEPTOR 68B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008775-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="54576" checksum="78C61B9697E47830" modified="2016-09-07" version="1">MKLYIFNPFHTKETEQLLPFYVREDFVMSPTADSKLNIFNGIPIRCTVFPRNPTLLPWGNLPEPFRRIRYVQQSVQASNGSGGLDGMMLGNLAVALNFTAETTDASDGQEYGYRLRNGTFVGSLGDLLQYTTDVSFNVRFMKFYDTHGIEFLHPIYSDQLCILSPKSLEIPQWLAIFLCFHPYVWASFVVIGFAGGYCWYVVRRWGLHKVRRYRQRLQKGDRARCAVLSIELWLVLLGASSTYLPVRMIERLLLIAFLIANLIISGTFQGTLTTAFSTKSYYKDLNTLAALDQSGWPIATSSRSLLDIFGNDSLSPLYLSLKGKLQILNESARQRAAYQRDVCCIERYSDVHLIINTEYIQPNGQPMLHVVDECPRVYSLAYIVRKGWPFTPLFNAAIFRFVESGLCMKWYGDTETALILHKRTKQLREQHEEPLLRKLTIIDMQTSFYIMALGMLISSIVFIVETFVGRGLQCSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPJ0</accession>
    <name>A0A182PPJ0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxysteroid 17-beta dehydrogenase 11</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPJ0"/>
    <dbReference type="STRING" id="199890.A0A182PPJ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008869-RA">
        <property type="protein sequence ID" value="AEPI008869-PA"/>
        <property type="gene ID" value="AEPI008869"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008869"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000498">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF729">
        <property type="entry name" value="MIP05442P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008869-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30116" checksum="D5B2CB6D5FA95310" modified="2016-09-07" version="1">DVSGQVVLITGGGGGVGRQLALNFARLRARVVIWDINKDALQGTVEALEAEGYRCRAYLVDISERERVYEAAKKVKQEVGNVQVLINNAGIVACRTLWDLTDKAIESTYAVNILSHYWTTRAFLPEMMNSNSGHIVTVGSVAGLLGTYGCTDYSATKFACVGFHEALFTELKTHGYDNIHMTLVCPYYINTGMFAGCRPRLLPMLEPKHVADSMVRSILKNEVNCTLPDHVRMFLPLKCLLPAKMCWELMYRVIKGPETMMGFRGRGKATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPP8</accession>
    <name>A0A182PPP8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPP8"/>
    <dbReference type="STRING" id="199890.A0A182PPP8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008927-RA">
        <property type="protein sequence ID" value="AEPI008927-PA"/>
        <property type="gene ID" value="AEPI008927"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008927"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008927-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="65720" checksum="A212DB83DFD0E8B0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ57</accession>
    <name>A0A182PQ57_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Platelet-derived growth factor (PDGF) family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PDGF/VEGF growth factor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQ57"/>
    <dbReference type="STRING" id="199890.A0A182PQ57"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009087-RA">
        <property type="protein sequence ID" value="AEPI009087-PA"/>
        <property type="gene ID" value="AEPI009087"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009087"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070851">
        <property type="term" value="F:growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000072">
        <property type="entry name" value="PDGF/VEGF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11633:SF1">
        <property type="entry name" value="LD28763P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11633">
        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00341">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00141">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50278">
        <property type="entry name" value="PDGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0339">Growth factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0497">Mitogen</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131785" description="Platelet-derived growth factor (PDGF) family profile domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Platelet-derived growth factor (PDGF) family profile" evidence="8">
        <location>
            <begin position="145"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009087-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="395" mass="44524" checksum="C1F116F00059AB08" modified="2016-09-07" version="1">MTMAAGSSTILLVALVLVLLPARAQQSADRTGAIIFPDELSNRYEQERTIAKEKRESSRRQNDEASGVTDEEKDEEQDHNSYESDEFFGLPLNYARQLSQLNSSADILPLLDPDSYDGRIFMDGGEYTGRDPGENPVPASCEPDLELVSLRPENLGAKYYHYPSCTRVKRCSGCCNTNQLVCEPVANRTILYKVSIVEYRQNKKDRFSHLELVPVEEHVRCKCQCRVKEWHCNERQVYNPNNCRCECLNKEERNVCAQESSEKQWNPTNCSCDCLPRNEECTSGTHYDRSACKCLPVSRESHTTPARRTKCRTTWALSTARHTTRALSTARHTMPALSTEVTAVVVPAPSTSTPPIVSFATVTIVAADYFYYLYLLSLVLRLLSLPVLPFATIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQH5</accession>
    <name>A0A182PQH5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine rich immune protein (Coil-less)</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQH5"/>
    <dbReference type="STRING" id="199890.A0A182PQH5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009206-RA">
        <property type="protein sequence ID" value="AEPI009206-PA"/>
        <property type="gene ID" value="AEPI009206"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009206"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009206-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44777" checksum="94906B8A547E5F00" modified="2016-09-07" version="1">MTDGFDTLRNIPPNTYFSVRVNMLSMPNNPSGTFLTRVSEFVNKLELSVFRDATFLIPPGVFLSSIQVLTALPMKQLIIGVGDNNVTELLFYTCGLEQVSPTIGNLPLLEELTLSGCAVRNFSLGTFARNRRLRILDLSFNQIESIVPPTRDISLAIEYLYLNSNQLEKLDMSAFASLASLSMIDLRSNNLARVVADRTITWSGMEMLDVSYNRLRTIDLQWLVAPNLKRLILSKNLFERIPDRLRRFPNLQLLVMSENNFTGGIDLAPLNGLPELNSVDFSNNPTARFLRSSRPLRLPVLDSLYVEYCSLSRFNTSSIDLPVVSFVSLSHNKFSTVPPLAQAFPSIVSFSLINNPLPCSALRLRSELILSGKLILGPPQTASACPDGSIQINSQYLFCCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQN4</accession>
    <name>A0A182PQN4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQN4"/>
    <dbReference type="STRING" id="199890.A0A182PQN4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009265-RA">
        <property type="protein sequence ID" value="AEPI009265-PA"/>
        <property type="gene ID" value="AEPI009265"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009265"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF444">
        <property type="entry name" value="PROTEIN SCABROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="46"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009265-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="312" mass="34924" checksum="21342FCC60322F3F" modified="2016-09-07" version="1">MPLEAGSKSDYNGTAGPQQPQRALTELERTTKLVQQLESVEHEYESIINKLPRDCSQIERMRTAGTANQPGDGGLYLIAPAEQHHPLMTQCFGEWTTVQRRQDGTVDFNRSWEEYAQGFGTPAGEFWIGNQALHHLTQDNCSRLRIVMQDIYDNTWFADYATFRIDSREAGFRLDLGGYSGNASDAFEYQNHMQFSAIDVDRDISNTHCAGNYEGGWWFSHCQHANLNGRYNLGLTWFDASRNEWIAVKSSHMMIARRPECDATVTELPVAVMEQPVTSGFGTSTPADATRSVHGTNDGSRQHGTTAAPTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQS0</accession>
    <name>A0A182PQS0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="STRING" id="199890.A0A182PQS0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009301-RA">
        <property type="protein sequence ID" value="AEPI009301-PA"/>
        <property type="gene ID" value="AEPI009301"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009301"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000028">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1034"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="431"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="1112"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="649"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009301-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1319" mass="148239" checksum="3961BFF2C0075B11" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQX7</accession>
    <name>A0A182PQX7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Anaphase-promoting complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the APC10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQX7"/>
    <dbReference type="STRING" id="199890.A0A182PQX7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009358-RA">
        <property type="protein sequence ID" value="AEPI009358-PA"/>
        <property type="gene ID" value="AEPI009358"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009358"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000019">
        <property type="entry name" value="Anaphase-promoting complex subunit 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028841">
        <property type="entry name" value="APC10_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009358-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="185" mass="21318" checksum="B5BCB69BDA54D3F3" modified="2016-09-07" version="1">MSVKMGANVCPIDEERSGTVREVGGHAVWSLSSCKPGFGVDQLRDNSMETYWQSDGQLPHLVNIQFHRKTTVSQIYIYSDYKLDESYTPSRISIRCGTHFNDLQEIEVVDLCEPSGWVCIPIKEYEEMLMCTFMIQIAVISNHQNGRDTHMRQIRIHSPTEGSQYPLEHHGKFSTIEFSQFRTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQY4</accession>
    <name>A0A182PQY4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQY4"/>
    <dbReference type="STRING" id="199890.A0A182PQY4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009365-RA">
        <property type="protein sequence ID" value="AEPI009365-PA"/>
        <property type="gene ID" value="AEPI009365"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009365"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013266574" description="Peptidase S1 domain-containing protein" evidence="10">
        <location>
            <begin position="36"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="117"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009365-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="393" mass="44153" checksum="BE1AFE13F85044BA" modified="2017-10-25" version="2">MDRSLRVTLNSRRCLVFAVLLLLTLLACCLSVAAATQPSLASYKRCSKGICVRRETCLNGQINTVGHMVIEPRMLGEDDIDECDKYGLMCCGLPEDEPVTTSTTEKPEDPDWSRQCGQRTDVDERTDQENETNRFEFPWHVAVFSVTKILGKLRKEFLCGGTLIDDYLVVTAARCVHQRNRATLVVQIGRWDLDARQEPRTQQIAVESLTVHRGYVPSSHLNNIALLELTNGVQLGRAANRVCLPDHTVQFDTDSLCYVVGWSNFPTPNTPNRQLKLRSTFAPARECTDSIRRATGAWEFRLPKENICPAYLDDSVPCERAPGSGMVCESSTGDGQYFLVGVASYAVRNCDKFRAHDVFLKVTAYIPWIDNQVEAQGRHTSFYRPDPSSFEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQZ4</accession>
    <name>A0A182PQZ4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQZ4"/>
    <dbReference type="STRING" id="199890.A0A182PQZ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009375-RA">
        <property type="protein sequence ID" value="AEPI009375-PA"/>
        <property type="gene ID" value="AEPI009375"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009375"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009375-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="69" mass="7753" checksum="32C0F43081BF8ADE" modified="2016-09-07" version="1">MLEEICYGALLKGGPIFIGYIGIDDLPFDVRGKPLQQARHWSAPEIFGPRAHFNTDTDPATLDIQKHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRE4</accession>
    <name>A0A182PRE4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRE4"/>
    <dbReference type="STRING" id="199890.A0A182PRE4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009528-RA">
        <property type="protein sequence ID" value="AEPI009528-PA"/>
        <property type="gene ID" value="AEPI009528"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009528"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005330">
        <property type="term" value="F:dopamine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051583">
        <property type="term" value="P:dopamine uptake involved in synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015874">
        <property type="term" value="P:norepinephrine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF320">
        <property type="entry name" value="SODIUM-DEPENDENT NORADRENALINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009528-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11383" checksum="E4A3E20917E4EB6E" modified="2016-09-07" version="1">MDGKSIPFWWYSIDGEALKELNGGAENGVGGDSEGTALAMTTVGQIKAKGRPGLLPRNGAGGELDDGEERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS54</accession>
    <name>A0A182PS54_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PS54"/>
    <dbReference type="STRING" id="199890.A0A182PS54"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009789-RA">
        <property type="protein sequence ID" value="AEPI009789-PA"/>
        <property type="gene ID" value="AEPI009789"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009789"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009789-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="153" mass="17558" checksum="DC492A7697EA728F" modified="2016-09-07" version="1">MAPNVLGNTLLLAEACIEQEDRSNNNNASIGTQQYKNKSFLNVAPKPAPVAEDLKPKEATKDAKVQETSTEYHHVYVWRNIIAFIYLHLGFLYGSYLLVTSAKWSTIIFELWSTLAIAQARRIRRMRRTGDNDLFYERHRPVDDSIDKRAQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSA1</accession>
    <name>A0A182PSA1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSA1"/>
    <dbReference type="STRING" id="199890.A0A182PSA1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009836-RA">
        <property type="protein sequence ID" value="AEPI009836-PA"/>
        <property type="gene ID" value="AEPI009836"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009836"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000376">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000392">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="106"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="201"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009836-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="326" mass="35915" checksum="612D63DDFCAFDF74" modified="2016-09-07" version="1">ITDPQFSTPILNVTAAVGREATLTCVVHDLGAYKVAWLRVDTQTILTIQNHVITKNKRIGITYTEKKTWQLRIKDIRETDRGWYMCQINTDPMKSQMGYLDVVVPPDILDYPTSTDMVVREGSNVTLRCAAVGSPAPAIVWRREAGDNISLQDGEQVSSVEGPTFTIPKVNRLHMGAYLCIASNGVPPSVSKRVMLIVHFPPMIWVPNQLVGAVEGQRMTLECHSEAYPRSINYWTREKGDIVPQGGKFEPALIDNAYKVVMKLSIKVVSLADFGAYKCIAKNSLGETDGTIKLYTAACLYADVAVDFGDGVKFSGGMLFQPPATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PT43</accession>
    <name>A0A182PT43_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PT43"/>
    <dbReference type="STRING" id="199890.A0A182PT43"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010129-RA">
        <property type="protein sequence ID" value="AEPI010129-PA"/>
        <property type="gene ID" value="AEPI010129"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010129"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000017">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010129-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="177" mass="18860" checksum="9BF232BA216990D9" modified="2016-09-07" version="1">MANCILRGSLSKPAMAFARTLVASQSSALPRVPLFTGSLLLSPVARKSQPLVGTTVRNFAVSPVRCSASGSHVTLWNAERALSLALLGVIPVGLMFPSQVGDTLMAVSIVMHQHWGLEAIVTDYVRPILFGTTVPKLAHGLLLIVSAATLGGLFYFNYNDIGIAGFVRKIWATKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTM3</accession>
    <name>A0A182PTM3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTM3"/>
    <dbReference type="STRING" id="199890.A0A182PTM3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010309-RA">
        <property type="protein sequence ID" value="AEPI010309-PA"/>
        <property type="gene ID" value="AEPI010309"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010309"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="12">
        <location>
            <begin position="267"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="11">
        <location>
            <begin position="707"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="816"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010309-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="993" mass="110132" checksum="D6F2119D330C1601" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTN0</accession>
    <name>A0A182PTN0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translocon-associated protein subunit beta</fullName>
            <shortName evidence="11">TRAP-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Signal sequence receptor subunit beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAP-beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTN0"/>
    <dbReference type="STRING" id="199890.A0A182PTN0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010316-RA">
        <property type="protein sequence ID" value="AEPI010316-PA"/>
        <property type="gene ID" value="AEPI010316"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010316"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008856">
        <property type="entry name" value="TRAP_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861:SF3">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05753">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016400">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131790" description="Translocon-associated protein subunit beta" evidence="13">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010316-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="192" mass="21186" checksum="6899BBB3C47D961B" modified="2016-09-07" version="1">MKSFLYALLALLAVSQLGLANEENTARLLVSKHILNKYLVEARDIVVKYTLYNVGSGPAVNVRLVDNGFHPEVFDVVGGQLTASIDRIAPQTNVTHIVVVRPKQYGYLNFTAAEVNYLATEDATEPQFSISSEPGEGAIVAEAQFNKQFSSHYLDWLAFAFLTLPSLAIPYAMWYSSKSKYEAMGKSSKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTW6</accession>
    <name>A0A182PTW6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PTW6"/>
    <dbReference type="STRING" id="199890.A0A182PTW6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010402-RA">
        <property type="protein sequence ID" value="AEPI010402-PA"/>
        <property type="gene ID" value="AEPI010402"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010402"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41158">
        <property type="entry name" value="AGAP010294-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41158:SF2">
        <property type="entry name" value="AGAP010294-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010402-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="306" mass="33116" checksum="639C7F8DFD089F8D" modified="2016-09-07" version="1">MHSRNMNQRAGINMLLLGLVLSNLVICTWSYPQQYQHQLHTVEQRKFAEKPNAIKKVALDDIDEIQTNQIQEGGFSWSNMLGLLMQMIFNGGGGGGGNVPTKSDDIDNGVSSFGQSPWANVISVGLKIITTLLGGGGAGDGIDKVDNGGSPMQNVLAAVFTAMFGAKDPDQVNTMAKQAGEFINIVVNLLDALKTSFSHRSLTARSLGKKDVISDATVASLSMMKGFVRSTRNADDRCMQKFLCEANMDCMGAIGGSSIFCQLGSYATSYILERQTGKSFESFYEAGRNGRSGFDCRQLYLECNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTZ0</accession>
    <name>A0A182PTZ0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PTZ0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010426-RA">
        <property type="protein sequence ID" value="AEPI010426-PA"/>
        <property type="gene ID" value="AEPI010426"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010426"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.80.10:FF:000003">
        <property type="entry name" value="Apolipoprotein lipid transfer particle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.230.10:FF:000007">
        <property type="entry name" value="Apolipoprotein lipid transfer particle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.50.20:FF:000003">
        <property type="entry name" value="Microsomal triglyceride transfer protein large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009454">
        <property type="entry name" value="Lipid_transpt_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06448">
        <property type="entry name" value="DUF1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0758">Storage protein</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vitellogenin" evidence="11">
        <location>
            <begin position="117"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010426-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="2757" mass="315449" checksum="0351BE389688CC8B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUG7</accession>
    <name>A0A182PUG7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUG7"/>
    <dbReference type="STRING" id="199890.A0A182PUG7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010603-RA">
        <property type="protein sequence ID" value="AEPI010603-PA"/>
        <property type="gene ID" value="AEPI010603"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010603"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12601">
        <property type="entry name" value="RRM2_SRSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000053">
        <property type="entry name" value="Serine/arginine-rich splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000507">
        <property type="entry name" value="serine/arginine-rich splicing factor 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="118"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010603-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="233" mass="26799" checksum="527A3678469B6466" modified="2016-09-07" version="1">MSHGRNECRIYVGNLPPDIRTKDIQDLFHKFGKVTFVDLKNRRGPPFAFVEFEDARDADDAVKARDGYDYDGYRLRVEFPRGGGPGSYRGSRQGNNDRNSRGGGDRGNRGPPARRSQFRVMVTGLPSSGSWQDLKDHMREAGDVCFADVYKDGTGVVEFLRHEDMKYAIKKLDDSRFRSHEGEVAYIHVREDSGNDEKRDYRDRSYSPRRRRGSPTYSPVQRSDSRSRSRSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUQ6</accession>
    <name>A0A182PUQ6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fibulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUQ6"/>
    <dbReference type="STRING" id="199890.A0A182PUQ6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010693-RA">
        <property type="protein sequence ID" value="AEPI010693-PA"/>
        <property type="gene ID" value="AEPI010693"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010693"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000139">
        <property type="entry name" value="Fibulin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000017">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055088">
        <property type="entry name" value="Fibulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF209">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22914">
        <property type="entry name" value="Fibulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="403"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="445"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="489"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="530"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010693-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="748" mass="83563" checksum="CF1979577E508531" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUR2</accession>
    <name>A0A182PUR2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUR2"/>
    <dbReference type="STRING" id="199890.A0A182PUR2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010699-RA">
        <property type="protein sequence ID" value="AEPI010699-PA"/>
        <property type="gene ID" value="AEPI010699"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010699"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000177">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131835" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="38"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010699-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="264" mass="28362" checksum="70FF070DCBE512D6" modified="2016-09-07" version="1">MKTFILRVPVTRVIALLGLITVAAALPQHSNAAPSPRIAGGEDAADGQFPFQVALINEGLVYCGGSVINRRWVLTAAACITGKALSDVQLYLGSADRLSGGRNVTAERFVIHPDFDAQTYANDVALVRLAESLAFTGDQLQPVRLATEFFETATDATVSGWGRLAISNNQLPVRLQFIRTDIIASDDCAEQFEEPYRSRISDRTICTSNLPDQGVCLGDAGGPLVLDGELVGVQSWSIPCGTGLPDVYERVSHHRAWILAIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVM1</accession>
    <name>A0A182PVM1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVM1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011008-RA">
        <property type="protein sequence ID" value="AEPI011008-PA"/>
        <property type="gene ID" value="AEPI011008"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011008"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131880" evidence="2">
        <location>
            <begin position="25"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011008-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="265" mass="27407" checksum="5153AC6D6742F5C2" modified="2016-09-07" version="1">MVSQLVWLCVGALFLYSAVHLADGNPIETVTANNPLLEPTAIGGAGPTLDTLLPTKPSEVASSTESSKMSRFLDDFTSAFKHGTAKMKESLESAASSVKDGVLQGYDYVRSKLTGGTGPESATVLPTLVGDDVTNNSSATPSTAAALTSTHTPSTERAAISGDAGASAGPADTKPNVLAALGGAVGVSNEPARIVPNDDEDDERIFFNDKDYTAVKPLDGSEDERDVTESPVTTTVAVDNRFIIAGPLACKSGQEVVNGKCRNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVP3</accession>
    <name>A0A182PVP3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PVP3"/>
    <dbReference type="STRING" id="199890.A0A182PVP3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011030-RA">
        <property type="protein sequence ID" value="AEPI011030-PA"/>
        <property type="gene ID" value="AEPI011030"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011030"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="216"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011030-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="290" mass="31852" checksum="72AD79453D4001FF" modified="2016-09-07" version="1">MFGNRYGYGGQSGYHGYSPYGGYSSMDYYGHRSYGGYGGYGQGYGGYGNPGGGYNFPEHRFIQLAEESSRPAFQILESLVGAVGNVATMLDSTFFAVTSSFRAVLSVAANLAHLKGTFAQFWSSLAVVRAAVWLYKKLLYKLRITKTDPTMEAFKEAFHVSTNSDGTGNNARKHSSSLLAVLFMGFMLSVPYMLIKMFAPKVSEDNATLIDPVMWNNPVEVQALYNFEATNPQEMTIRAGQALLLAPKQIQTDRHLLNSGWVLAATTDRKTSGIIPLTYVQSLKQAVESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWE0</accession>
    <name>A0A182PWE0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWE0"/>
    <dbReference type="STRING" id="199890.A0A182PWE0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011277-RA">
        <property type="protein sequence ID" value="AEPI011277-PA"/>
        <property type="gene ID" value="AEPI011277"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011277"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011277-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="115" mass="13195" checksum="6D24F2EBF240D1DB" modified="2016-09-07" version="1">MCKTLWLAEGFCTALQCVTGRIKCGVKLHHKEKDNRVALVTAPPSYTPRMYHYFPAHMTHPFCYYPSLAPQQARYPGLFMRPDETNLYTTLEQTMSSNPNVYFQRGGGVHPGMMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWE2</accession>
    <name>A0A182PWE2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWE2"/>
    <dbReference type="STRING" id="199890.A0A182PWE2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011279-RA">
        <property type="protein sequence ID" value="AEPI011279-PA"/>
        <property type="gene ID" value="AEPI011279"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011279"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.180.11">
        <property type="entry name" value="Methuselah ectodomain, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052808">
        <property type="entry name" value="GPCR_Mth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023311">
        <property type="entry name" value="Methusela_ecto_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036272">
        <property type="entry name" value="Methuselah_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63877">
        <property type="entry name" value="Methuselah ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011279-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="57834" checksum="7F034827676E524D" modified="2016-09-07" version="1">MNPTVLSKLFTLTICVKLPIQPTYVSRDASVIRKCCPQGESLMSEYSLYLSCQGNSAFASAALPQAIVAQFYRECIEDLEEDIQLQERYGNPCPNEDAMVSFSARTNDTLYVIQNGSLLVIYGGKYYDVYNTYCLDFDRTDGTLVGYVCAAEVTVVADLVQGQLLLLTICLIVAIPALLVTALLYILVPKLRDLHGRALAMNCVNFAIALLLECFFQYRNRGNRMLLDDMALENYAEYFILATFFWLLVNCANNCFHAWYYVPQGKHTKTSDKNKRFAAYAVFAQLLPLLIILQYSTTPSGTPAIKHYLFIPIGVTLGLGFTFLIVTFLGLANLKDKYYYCHEIRQRLVLEGRYEEVCKYEPVCGLKVNKVIYMYKYTVPLFVVMATIWTVMALTYYATYELPIFYDILFGFQGILIFVIFICMPRPYDTIREWFIEQRYCGWMCQAEPAEVPMVASEMVPMKRHIAPMQMMARTCAAEVHSFSAYMAGPVRLKRSKNPFTYLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWK5</accession>
    <name>A0A182PWK5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWK5"/>
    <dbReference type="STRING" id="199890.A0A182PWK5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011342-RA">
        <property type="protein sequence ID" value="AEPI011342-PA"/>
        <property type="gene ID" value="AEPI011342"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011342"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011342-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="195" mass="22013" checksum="EC1E0AB25E6A3D5B" modified="2016-09-07" version="1">HVDPEIDKFTIDVSIDGLPLFKSSRKQLWPIQIRVLELIKTPPFIVGTFGGSMKPGNLEEFLNPFVEEINDLQQRGILFEKKLVPFFLRAVIADSPMRATLKATMNFNARHGCLKCTCVGTSISTGPNSKKIILDSVDADPRTDAGFRERIDACHHKEWRSPLEDIHNFDMVENVPVSERMHLVDEGVTQKILMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E1MX08</accession>
    <name>A0A1E1MX08_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Signal transducer and activator of transcription</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">STAT-B</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Gene" volume="0" first="0" last="0">
            <title>The evolutionary divergence of STAT transcription factor in different Anopheles species.</title>
            <authorList>
                <person name="Gupta K."/>
                <person name="Dhawan R."/>
                <person name="Kajla M."/>
                <person name="Misra T."/>
                <person name="Kumar S."/>
                <person name="Gupta L."/>
            </authorList>
            <dbReference type="PubMed" id="27664587"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the transcription factor STAT family.</text>
    </comment>
    <dbReference type="EMBL" id="BK009274">
        <property type="protein sequence ID" value="DAA79950.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E1MX08"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015477-RA">
        <property type="protein sequence ID" value="AEPI015477-PA"/>
        <property type="gene ID" value="AEPI015477"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015477"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09919">
        <property type="entry name" value="SH2_STAT_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14801">
        <property type="entry name" value="STAT_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.20">
        <property type="entry name" value="STAT transcription factor, all-alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.630">
        <property type="entry name" value="STAT transcription factor, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.532.10">
        <property type="entry name" value="STAT transcription factor, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048988">
        <property type="entry name" value="STAT_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036535">
        <property type="entry name" value="STAT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013800">
        <property type="entry name" value="STAT_TF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015988">
        <property type="entry name" value="STAT_TF_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013801">
        <property type="entry name" value="STAT_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012345">
        <property type="entry name" value="STAT_TF_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013799">
        <property type="entry name" value="STAT_TF_prot_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01017">
        <property type="entry name" value="STAT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02864">
        <property type="entry name" value="STAT_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02865">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21354">
        <property type="entry name" value="STAT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00964">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47655">
        <property type="entry name" value="STAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48092">
        <property type="entry name" value="Transcription factor STAT-4 N-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="9 12" id="KW-0010">Activator</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="STAT transcription factor protein interaction" evidence="13">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU046415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="DAA79950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015477-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="738" mass="85301" checksum="E34435F5B7968C88" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PKY0</accession>
    <name>A0A240PKY0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PKY0"/>
    <dbReference type="STRING" id="199890.A0A240PKY0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015236-RA">
        <property type="protein sequence ID" value="AEPI015236-PA"/>
        <property type="gene ID" value="AEPI015236"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015236"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035275">
        <property type="term" value="F:dibutyl phthalate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
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        <property type="entry name" value="PBP_GOBP_sf"/>
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        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364:SF1">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN LUSH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015236-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="156" mass="18229" checksum="4D794B7009E8A084" modified="2017-10-25" version="1">MPAKSRSYWWRWVWEYTLGFMLLFPISLNFVDCAMTRKQLINSMDMMRSACAPKFKVSTEMLDNLRGGIFAEDRELKCYTMCIAQMAGTMNKKGEINIQKTIAQMDAMLPPDMKEKAKEAIQSCREVQGRYKDSCDKTFYSTKCLAEYDREVFLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZF0</accession>
    <name>A0A182NZF0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZF0"/>
    <dbReference type="STRING" id="199890.A0A182NZF0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000030-RA">
        <property type="protein sequence ID" value="AEPI000030-PA"/>
        <property type="gene ID" value="AEPI000030"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000030"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="42"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000030-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="93" mass="10666" checksum="FBBCBE97736BD8E4" modified="2016-09-07" version="1">MAAAVQGSPRTGDESSESENETEPAKIFHRKLSTKKDVKSATAVKEGYLMKQTWSFQRWRRRYFRLKGHKLYYAKDSKVNEIPFDSTSTSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZP0</accession>
    <name>A0A182NZP0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myosin tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182NZP0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000121-RA">
        <property type="protein sequence ID" value="AEPI000121-PA"/>
        <property type="gene ID" value="AEPI000121"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000121"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF36">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-LIKE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin tail" evidence="4">
        <location>
            <begin position="658"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1219"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="572"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="647"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1225"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1269"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1311"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1323"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000121-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1498" mass="167117" checksum="7E9211B4B88BD384" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P045</accession>
    <name>A0A182P045_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RIIa domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P045"/>
    <dbReference type="STRING" id="199890.A0A182P045"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000277-RA">
        <property type="protein sequence ID" value="AEPI000277-PA"/>
        <property type="gene ID" value="AEPI000277"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000277"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12100">
        <property type="entry name" value="DD_CABYR_SP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047579">
        <property type="entry name" value="DD_CABYR_SP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699:SF11">
        <property type="entry name" value="IGLOO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699">
        <property type="entry name" value="NEUROMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="2">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000277-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="378" mass="43638" checksum="42478FC4875F3F50" modified="2016-09-07" version="1">MNYLLHRQHSPGAVIPIPEGLEELMQDISREVLHAQPPNVITFLADYLEEKLVRRENSRVAEKIVDNVLDISLDIVAMLEAIGIDSTRAQAAVKRIREEFHRHFETKPDDERLRDTFRERDVLERLVRECHFSEQEARKASRIIENAYRTYYFRNAYQEPQEVGKDKDWRQAAKHTLCLYAQTDPTKEEMEAAARRIQVAYRAYYKRKRAELDRNATIIQHAVRAYRRRRLEETEIAGVPSEVIAREIVDVPRDEHYTPSEDIRHLINVATGSDEATPRDMTVDEAATVLQSVVRGHQARKHNAVASASKKPSTDKLAARHLDQAATLLQSTARGHLARKRLQEERTKHQMATVLQSHARGYLARKRLPRNEPSDPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0K7</accession>
    <name>A0A182P0K7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an olfactory role that is not restricted to pheromone sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0K7"/>
    <dbReference type="STRING" id="199890.A0A182P0K7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000439-RA">
        <property type="protein sequence ID" value="AEPI000439-PA"/>
        <property type="gene ID" value="AEPI000439"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000439"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF89">
        <property type="entry name" value="GH15894P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000439-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="195" mass="22659" checksum="0C6D17718A29BBCD" modified="2016-09-07" version="1">MEDDNYFMKRGFNFIYTLSGDTVFSTMTVYDYLWNTRPPFLNQARKFVPGMVPSDNVGVLKTMYEDHEDHVNVRHGKRYGDDQFFMMNTYEYEPTVPGFSLARGDCFASIQNSSEGATYPQNLDEQSVLIYWRKTLCRAVPLYYERRVQKGALTGYKYVLPDDSYDRLPDSDTDCYKGQYGLLENGMTDTSKCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0K8</accession>
    <name>A0A182P0K8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an olfactory role that is not restricted to pheromone sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0K8"/>
    <dbReference type="STRING" id="199890.A0A182P0K8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000440-RA">
        <property type="protein sequence ID" value="AEPI000440-PA"/>
        <property type="gene ID" value="AEPI000440"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000440"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF89">
        <property type="entry name" value="GH15894P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000440-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="149" mass="17620" checksum="58DD0045DA679604" modified="2016-09-07" version="1">LFIICFTTSLSIVCFTLGLFFHIYKPTQLILDDRLTMRQIMPYYRWWKDTADVLVTCRVFIFNVTNSDRWLAGLDEQLKLDEVVPIVYREMLEHDNVTFHEHNSTMSYLTRRRLEFLPDRNVPGILNKTIVVPNISLLASLLQFFADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1C7</accession>
    <name>A0A182P1C7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1C7"/>
    <dbReference type="STRING" id="199890.A0A182P1C7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000709-RA">
        <property type="protein sequence ID" value="AEPI000709-PA"/>
        <property type="gene ID" value="AEPI000709"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000709"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000022">
        <property type="entry name" value="AGAP012066-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000114">
        <property type="entry name" value="Calpain a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="28"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="648"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000709-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="82660" checksum="48C27CF718DD7CE4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1U7</accession>
    <name>A0A182P1U7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TEP1-F</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of a TEP1-N chain and an TEP1-C chain non-covalently linked. Forms a complex composed of TEP1-N and TEP1-C heterodimer, LRIM1 and APL1C; the interaction stabilizes TEP1-N and TEP1-C heterodimer, prevents its binding to tissues while circulating in the hemolymph and protects the thioester bond from hydrolysis. Mature TEP1 and to a lesser extent full-length TEP1 interact with SPCLIP1; the interaction is induced by microbial infection.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1U7"/>
    <dbReference type="STRING" id="199890.A0A182P1U7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000881-RA">
        <property type="protein sequence ID" value="AEPI000881-PA"/>
        <property type="gene ID" value="AEPI000881"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000881"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049135">
        <property type="entry name" value="TEP1_CUB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21412">
        <property type="entry name" value="TEP1_CUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="11">
        <location>
            <begin position="427"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="12">
        <location>
            <begin position="632"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000881-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1211" mass="137710" checksum="BADA62E101176570" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1V3</accession>
    <name>A0A182P1V3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TEP1-F</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of a TEP1-N chain and an TEP1-C chain non-covalently linked. Forms a complex composed of TEP1-N and TEP1-C heterodimer, LRIM1 and APL1C; the interaction stabilizes TEP1-N and TEP1-C heterodimer, prevents its binding to tissues while circulating in the hemolymph and protects the thioester bond from hydrolysis. Mature TEP1 and to a lesser extent full-length TEP1 interact with SPCLIP1; the interaction is induced by microbial infection.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P1V3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000887-RA">
        <property type="protein sequence ID" value="AEPI000887-PA"/>
        <property type="gene ID" value="AEPI000887"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000887"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049135">
        <property type="entry name" value="TEP1_CUB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21412">
        <property type="entry name" value="TEP1_CUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="11">
        <location>
            <begin position="417"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="12">
        <location>
            <begin position="626"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="13">
        <location>
            <begin position="1242"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000887-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1335" mass="149474" checksum="668FBCB1F992D2C7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2B7</accession>
    <name>A0A182P2B7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182P2B7"/>
    <dbReference type="STRING" id="199890.A0A182P2B7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001051-RA">
        <property type="protein sequence ID" value="AEPI001051-PA"/>
        <property type="gene ID" value="AEPI001051"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001051"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001051-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="309" mass="35531" checksum="2D674D4120A2C549" modified="2016-09-07" version="1">MEDKAMLKDLDQWIEQLNECKQLTESQVKILCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYCERITILRGNHESRQITQVYGFYDECLRKYGNPNVWKFFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISEMFNHTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDALKFSFLQFDPAPRRGEPHVTRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P306</accession>
    <name>A0A182P306_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P306"/>
    <dbReference type="STRING" id="199890.A0A182P306"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001294-RA">
        <property type="protein sequence ID" value="AEPI001294-PA"/>
        <property type="gene ID" value="AEPI001294"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001294"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025086">
        <property type="entry name" value="SDE2/SF3A3_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13297">
        <property type="entry name" value="SDE2_2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001294-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="484" mass="57246" checksum="3E27439DC60DC923" modified="2016-09-07" version="1">METIFEIQRRLHEECDRLVMAMSEELMIPKKTTKEKVLADHRIKIYLERYQTCSKSLLELYQDKDGERKQEITNMSVNEFKEFYSQFNGLIEFHSNHGNNVAVPASIEFDKLKEQLNDPAYLAEVVKFSDVENYGQYLDLHECYDNFVNLKGIDKIDYITYLSEFNKFADIPRKQKNLKYKGYLQLLHDYLYSFITRSRPLFFELEHTVKRNELQFEDMWKNGIVPGWEKVRDVDDDALINLNEFGKWEDLTYLGLDRLKAALQALGMKCGGTLEERAQRLFASKDDKNQENERKRMMNLNKEKDIALLEYKIAKLSELVDDQIYETKINLQRKQARYTLDESDEDSMDEEESDDDDGIPYNPKNLPLGYDGKPIPYWLYKLHQLHFTYECEICGNYKYNGPKAFQNHFSEWRHAHGMRCLGIPNTAHFANITKIEDALVLWDKVKEQTFSKMWVPANEEEFEDSRGNILSKKVYLDLQKQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P308</accession>
    <name>A0A182P308_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P308"/>
    <dbReference type="STRING" id="199890.A0A182P308"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001296-RA">
        <property type="protein sequence ID" value="AEPI001296-PA"/>
        <property type="gene ID" value="AEPI001296"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001296"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="98"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001296-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="414" mass="46829" checksum="1BF8EA7E3E8122B1" modified="2016-09-07" version="1">HEFDDDDRSAEIEEDPPFNVKEEDAYLTVPQLVWKYGYEIEIHEVQTEDGYLLDLYRISGRRAASGQPALRPYRNAPIFLMHSLLSSCADWVLMGPGRGLGYLLADAGFDVWMGNARGTRYSRKHIHLDPDRSGEFWNFSWHEIGLYDVRALIDHVLNVTGAARLHYGGFSQGTMVLFVLLSERPEYNTKLIDMQAISPSVYMYRLEGQIVRTFVQLADPLVAALDTIGRREILPNLRFIAPLVKIVCADSNVTACRELLYDVAGKNPPQVDDRMVRIFLGHFPAGASLRQLHHFSQIIRTARFAKYSPLRFAENGVPSFSPAPLYNLTRATIPVVVYYGLNDHVVNFRDALQLADEVPNLAAVHQIADRRFTHSDFILAKNSARLLNSILLQELNQYDGATGSASVNVTHWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3C3</accession>
    <name>A0A182P3C3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding motif protein 26"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="PWI_dom"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RBM26/27"/>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
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        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nup35_RRM_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PWI"/>
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        <property type="entry name" value="RRM_1"/>
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        <property type="match status" value="2"/>
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    </feature>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="819"/>
            <end position="838"/>
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    </feature>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="1052"/>
            <end position="1091"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="1178"/>
            <end position="1283"/>
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        <location>
            <begin position="160"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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            <begin position="201"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001408-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1283" mass="134277" checksum="BFB0D507AAD9ACA5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3I3</accession>
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        <recommendedName>
            <fullName evidence="2">14-3-3 protein zeta</fullName>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2021-01" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 14-3-3 family.</text>
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        <property type="protein sequence ID" value="AEPI001468-PA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="14-3-3"/>
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        <property type="entry name" value="14-3-3_CS"/>
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        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
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        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00068216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001468-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="248" mass="28345" checksum="D3BF218D9883340B" modified="2016-09-07" version="1">MSTVDKEELVQKAKLAEQSERYDDMAQAMKSVTETGVELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTESSARKQQLAREYRERVEKELREICYEVLGLLDKFLIPKASNPESKVFYLKMKGDYYRYLAEVATGETRHTVVEDSQKSYQEAFDIAKSKMQPTHPIRLGLALNFSVFYYEIINSPARACHLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDTQGDGDEPQEGGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P467</accession>
    <name>A0A182P467_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P467"/>
    <dbReference type="STRING" id="199890.A0A182P467"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001703-RA">
        <property type="protein sequence ID" value="AEPI001703-PA"/>
        <property type="gene ID" value="AEPI001703"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001703"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027993">
        <property type="entry name" value="DUF4495"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960:SF1">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14906">
        <property type="entry name" value="DUF4495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001703-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="890" mass="99892" checksum="EBF3E13A0D6D3ED1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4P7</accession>
    <name>A0A182P4P7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription factor IIH subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor IIH polypeptide 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4P7"/>
    <dbReference type="STRING" id="199890.A0A182P4P7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001883-RA">
        <property type="protein sequence ID" value="AEPI001883-PA"/>
        <property type="gene ID" value="AEPI001883"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001883"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13159">
        <property type="entry name" value="PTB_LDLRAP-mammal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PID" evidence="13">
        <location>
            <begin position="45"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001883-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="507" mass="56810" checksum="04BD10BFADD8CA93" modified="2016-09-07" version="1">MAFFKSIWKNSSKHKKLCEELALANSIRDFSENHDDLEDGSNEAISYSVKYLGNTPVPTPRSENATAEAVKSIITAAKGNKKLQRVSLSISPKGIEMIDTGTGETLLQVSIYQISYCSADANHDHVFAFVGCTLGSEAEVKEMCFRRTAEEINLEGPLVCHAFLCQKRKMAQTVTLTVARSFERAFQIWQSKQFHAERKRKELEERMERELHGSQELARKNASNETSSNGQQQQRDDGASECRSLLIDFNSELTDICSDAHHHRELLQNTWGLIASLKLKGRQFLYPTPGKPLDIRQVDGQYEVFTLVEKTIKQKLAHMINTAPPLTTPTESLLAGSMSMALCYIARINRNKAPGTKINSRVLVVTGSNECASQYMTYMNVFFTAQKQGVVVDVCALDKALSLLQQGCDITGGQYLRLEQLEGFLQYLLWVFLPDPQMRCKLVLPPPVKVDYRAACFCHRELIDIGYVCSVCLSIFCKFSPICTTCHTVFKAPAPIVAKPKKKKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P558</accession>
    <name>A0A182P558_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P558"/>
    <dbReference type="STRING" id="199890.A0A182P558"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002046-RA">
        <property type="protein sequence ID" value="AEPI002046-PA"/>
        <property type="gene ID" value="AEPI002046"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002046"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31532">
        <property type="entry name" value="BIORIENTATION OF CHROMOSOMES IN CELL DIVISION 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31532:SF10">
        <property type="entry name" value="BIORIENTATION OF CHROMOSOMES IN CELL DIVISION PROTEIN 1-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002046-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="938" mass="104080" checksum="454C8E262C8C49EA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P595</accession>
    <name>A0A182P595_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar protein 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P595"/>
    <dbReference type="STRING" id="199890.A0A182P595"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002083-RA">
        <property type="protein sequence ID" value="AEPI002083-PA"/>
        <property type="gene ID" value="AEPI002083"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002083"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.40:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002083-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="64" mass="7579" checksum="977E504B66445DE9" modified="2016-09-07" version="1">MYLMYDLNENGERVYTLKKNNAVGKPTQSAHPARFSPEDKYSRYRIIIKKRFGLLLTQKPEPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5A1</accession>
    <name>A0A182P5A1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182P5A1"/>
    <dbReference type="STRING" id="199890.A0A182P5A1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002089-RA">
        <property type="protein sequence ID" value="AEPI002089-PA"/>
        <property type="gene ID" value="AEPI002089"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002089"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20352">
        <property type="entry name" value="Rcat_RBR_RNF144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000010">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002089-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="294" mass="32054" checksum="F36FAE8C2A289227" modified="2016-09-07" version="1">MTAYIEFEISEGAYEVSCPDAMCPAQGIITIAEITALASSSLVEKHHRYRLNREVELDRFRTWCPKAGCETICLVGPAEQQAGQTGANQTGSSICSDRIVPLSPSSSSMPSPCAVHCPTCREDFCSGCKKTWHPTMSCEENSRRLAVDGQTDALGIPFDNDLIKCCPMCTVPIEKDEGCAQMMCKRCKHVFCWYCLASLDDDFLLRHYDKGPCKNKLGHSRASVVWHRAQVIGIFAGFGILLLVASPLLLLAAPCIVCCKCRICSGAAKLEETEVDYDDAAVALHSSSSNGPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5B2</accession>
    <name>A0A182P5B2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5B2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002102-RA">
        <property type="protein sequence ID" value="AEPI002102-PA"/>
        <property type="gene ID" value="AEPI002102"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002102"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002102-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="309" mass="34489" checksum="F8DBFCDE743EFD1A" modified="2016-09-07" version="1">MPFAIVEILGSTNGEGLLVVPETWLVRERNGVSFVYWPDTKRVTNVNLLLADDQSSPMDVWEKRLCKIVCDNISSLTLAAKTLQILRKRKATVNATTTGRTALDAKKTLLVSGHVIKCEQETVKLSDSVPEDSFNACTKVQDPLSDPSNPGPKVGLEQSGSSEFVIKEEEEQELFSMLEVEQQSDPFEDIAKIAKFGTIAPSLRSSVHDEKVNEMTAMEQDETAEQGLIIEEEEIIGEEIVQAEDVFGRDALVEQQKEKHTHAVRCGKKDKMQIKQERGGCSARLLGSTEREWNDVRFHAQVGMQQEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5I4</accession>
    <name>A0A182P5I4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5I4"/>
    <dbReference type="STRING" id="199890.A0A182P5I4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002174-RA">
        <property type="protein sequence ID" value="AEPI002174-PA"/>
        <property type="gene ID" value="AEPI002174"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002174"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130869" evidence="3">
        <location>
            <begin position="18"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002174-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="355" mass="37995" checksum="A05567FB111EC348" modified="2016-09-07" version="1">MCKVALVVLALAGVALAYEHHGFVSEVKHIPYKFIGGGGIGGGQEGGLEGGFEGKDYYAYPKYKFEYGVKDYHTGDHKSQWEVRDGDVVKGEYTLDEPDGSTRIVKYHADSKNGFEAVVKNIGKGGQQQEGGSIGGGEEGISGGYGGYGHGYSYSKLKKKRKSIGEEAQETKKQFCKMNKFSVVMVLALAGVCLAYEHHGFVSEVKHIPYKYYGGGEIGGGIGGGEEGGFESGIGGGIGGGFEGGYEGKDYYAYPKYKFEYGVKDYHTGDHKSQWEVRDGDVVKGEYTLDEPDGSTRIVKYHADSKNGFEAVVKNIGKGGLQQEGGSIGGGEEGISGGYGGYGHGYSYSKLKKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5R0</accession>
    <name>A0A182P5R0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5R0"/>
    <dbReference type="STRING" id="199890.A0A182P5R0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002251-RA">
        <property type="protein sequence ID" value="AEPI002251-PA"/>
        <property type="gene ID" value="AEPI002251"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002251"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060560">
        <property type="term" value="P:developmental growth involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF98">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002251-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="329" mass="37433" checksum="DE4FED85A4CECD87" modified="2016-09-07" version="1">MCVLSLLWRKRIPRGYRESAFAYAIAAAGVTHSVARACAQGRLISCGCDPSVNRKGMSKSLRESLEKEKLRFLDAIAESNSVFEEGDSLRKLKAKQASRWKWGGCSHNMAFGVEFSELFLDSREKGADIQSQINLHNNRAGRRAVSNHMQVRCKCHGMSGSCQLKTCWKSAPDFRVVGRVLKQQYRRAILVDQSNLGNGPPMIVYRKPKKRKHVPNLRPPRRHPREQQLVPLANRLGGPPNRKLENALFYYQRSPNFCERDQISDIPGTIGRRCNRTSSGSEGCASMCCGRGYNLIREKRIDRCNCKFHWCCFVECDDCEIEEWISVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5R3</accession>
    <name>A0A182P5R3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Selenoprotein P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5R3"/>
    <dbReference type="STRING" id="199890.A0A182P5R3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002254-RA">
        <property type="protein sequence ID" value="AEPI002254-PA"/>
        <property type="gene ID" value="AEPI002254"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002254"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007671">
        <property type="entry name" value="Selenoprotein-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04592">
        <property type="entry name" value="SelP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Selenoprotein P N-terminal" evidence="8">
        <location>
            <begin position="504"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002254-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="837" mass="92438" checksum="B55CD71302CA06BF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P626</accession>
    <name>A0A182P626_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PKI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P626"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002369-RA">
        <property type="protein sequence ID" value="AEPI002369-PA"/>
        <property type="gene ID" value="AEPI002369"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002369"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004171">
        <property type="entry name" value="cAMP_dep_PKI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15416">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE INHIBITOR/PKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02827">
        <property type="entry name" value="PKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002369-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="111" mass="11231" checksum="8B43B50F24DA1772" modified="2016-09-07" version="1">MDKLRESGAGTDPSTQQRLASNAEGTGTAQTGGGEGCSDEFHHQFYNTGRIGRRNALPDILGTHCTTTTADLSSQLGALSTSDCVASKASDASSSIASGNNGQPPPTTTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6C9</accession>
    <name>A0A182P6C9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6C9"/>
    <dbReference type="STRING" id="199890.A0A182P6C9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002477-RA">
        <property type="protein sequence ID" value="AEPI002477-PA"/>
        <property type="gene ID" value="AEPI002477"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002477"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004948">
        <property type="entry name" value="Nuc-triphosphatase_THEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146">
        <property type="entry name" value="CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146:SF1">
        <property type="entry name" value="CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03266">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002477-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="20899" checksum="18A788C368BA19C6" modified="2016-09-07" version="1">MSLILVTGMPGVGKTTIMCKVGDELAKRNVPIAGFYTEEVRDPRAGGDRVGFDVVTFTGQRAALARLSSNTSTKAPTVGRYAVCVEEFERLAIPALGSRNSGAIATNGVLLLDEIGRMEFKSRSFGASMDAIVKEVSTGKLRFVATIPLKSSGMEVIERLKRIAGCQIFHVKPSNRDEMYGAVRDAVLRLVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6F9</accession>
    <name>A0A182P6F9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6F9"/>
    <dbReference type="STRING" id="199890.A0A182P6F9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002507-RA">
        <property type="protein sequence ID" value="AEPI002507-PA"/>
        <property type="gene ID" value="AEPI002507"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002507"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23683">
        <property type="entry name" value="IFT52_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039975">
        <property type="entry name" value="IFT52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055460">
        <property type="entry name" value="IFT52_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055458">
        <property type="entry name" value="IFT52_GIFT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969">
        <property type="entry name" value="NGD5/OSM-6/IFT52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23352">
        <property type="entry name" value="IFT52_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23355">
        <property type="entry name" value="IFT52_GIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT52 GIFT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="IFT52 central" evidence="1">
        <location>
            <begin position="265"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002507-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="432" mass="49125" checksum="FEA00E3756CF5A51" modified="2016-09-07" version="1">MSNATILFNVSKNELFKLPDNYKTLHRKLKVNHRVESNKSEITPEILKTANVFVLAGPQEKFTETEFQHLKDYINEGGRLLLLLGEGGEVQFNTNVNFLLEDYGMTINNDVVVRPQYYKYFHPKEALISGGVSCDSMNNLLLESSKSVLTSFDFMDDKYKVEFVYPFGATMNIISPANVLLTTGPVVYPFNRPLAGYFQNENNGKLVAIGSGHMFQDKYISNEVNTALWDSLLAMILQDEFKFKSSDFNDLEINDYAVIPDTIYLAEQPKICLMDSLDYDIPADFKKLFDMSLYSINNDLLRDVIGTYEKLDVQYEPLKIIKPQFEIPLPPLQLAVFQPIFSDLAAPPLELFDLDEAFSSEKVQITQLTNKCLLPAQDGGGQRAVDEKELGYFIQECGRILKVCQDDQKMSPKEILNSISVKIAHYKKLDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6Q2</accession>
    <name>A0A182P6Q2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6Q2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002600-RA">
        <property type="protein sequence ID" value="AEPI002600-PA"/>
        <property type="gene ID" value="AEPI002600"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002600"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398:SF4">
        <property type="entry name" value="AGAP002980-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130910" evidence="1">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002600-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="237" mass="26906" checksum="AD24B240FB5644B8" modified="2016-09-07" version="1">MHLTAVLCLSLFAASCLSLNHTELVDSPSRRALSRQERKVLLFPILTTLQVSICTATDGRLFAPKKKYPARKLGINLGFQQNFNLPFRLLEFYRPPTWARAIAGILRGQFPSTSVVTARRWKRSTDHQSLMLSAGQLYRFVEDMLHVFGYGRDCLVKSVCELAHSPFEPSDRERDVMTEVVHLLLSPSVHESFGEDELQQKRAYEMAERLGASGANCDLIYDRCHRSVLSDFSNLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P746</accession>
    <name>A0A182P746_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P746"/>
    <dbReference type="STRING" id="199890.A0A182P746"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002748-RA">
        <property type="protein sequence ID" value="AEPI002748-PA"/>
        <property type="gene ID" value="AEPI002748"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002748"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14969">
        <property type="entry name" value="7tmA_Opsins_type2_animals"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002748-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="367" mass="40576" checksum="99D327C66B726A2C" modified="2016-09-07" version="1">MKITVACRCIHSFRLFIRNVFSFFAGIASITTLTVLSYERFCLISRPFAAQNRSKQSACLAVLFIWSYAFALTSPPLFGWGAYVNEAANISCSVNWESQTTNATSYIIFLFIFGLILPLAVIIYSYINIVLEMRKNSARVGRVNRAERRVTSMVAVMIVAFMVAWTPYAIFALIEQFGPPDLIGPGLAVLPALVAKSSICYNPIIYVGMNTQFRAAFWRIRRSNGVAGQPDSNNTNNSNRDKESRNTAKDVLECSLDFCHWTVRGTRVSISSVDRNAQPTQGSRERSGGNSAGSRDGERDRSGALRAMLTSPRSPSSIAPEAADCSVTDVRTCSGDSRFVRQDSELSVIHDGRVLVIKSQKPRSNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P757</accession>
    <name>A0A182P757_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P757"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002759-RA">
        <property type="protein sequence ID" value="AEPI002759-PA"/>
        <property type="gene ID" value="AEPI002759"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002759"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002759-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="72" mass="8028" checksum="02FE5DF375B46335" modified="2016-09-07" version="1">MVIESAITISIPRCPRNEVYTCCGPCVQKSCRTIKETVYCLLPCTEGCVCRNGYVRRVPDGLCVPIRSCQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7J4</accession>
    <name>A0A182P7J4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat DCAF10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P7J4"/>
    <dbReference type="STRING" id="199890.A0A182P7J4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002897-RA">
        <property type="protein sequence ID" value="AEPI002897-PA"/>
        <property type="gene ID" value="AEPI002897"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002897"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000661">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039085">
        <property type="entry name" value="DCA10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14588">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14588:SF2">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002897-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="505" mass="56709" checksum="E79D6D2CF33AE36C" modified="2016-09-07" version="1">MSLHEWYRRRERGLPSRIGDTDMIYRTIFRSLQPRALTSELSHPYRCGQDSGAICNLEFSPDGTLLAAACEYKSIVLFDPLTEKQVCAVNNAHEGSVNCIKFVDSRTFASCSDDTTVALWDSRNLSTKLRTLNGHSGWVKNLEYAKGAGVLLSSGLDGLVYAWELNSSTEQGCMYQRLLYMPGLMRCRLAPDETRLVLCTSSGYLMLVHDLNLASFAGDLVDFRPNIHRLNLMRKQRMPPGSRKTPAVSHRRKRNRIEFVSDFPPGDEAEMISGLTWSVVHDIQSWSEEEDDSGMGQECEDSEKQQDTPEAEQERRHCNVHLDPKREPSESLLVEAKCCTGATERNVINNAFPCHSGASCPADAPHLRLSPAKGNIFGFDRSTHSKRPGKSTTSEPASRLLYYIQESNKVEGYMREACFSPDGRVICSPHDDYGVRLLAFNEQCNEMRYARQCLPDGAEPALLRELKYRPGYPHVVISSQFSPRFPLLVTGCLLGNVVWNLPVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8H5</accession>
    <name>A0A182P8H5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P8H5"/>
    <dbReference type="STRING" id="199890.A0A182P8H5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003228-RA">
        <property type="protein sequence ID" value="AEPI003228-PA"/>
        <property type="gene ID" value="AEPI003228"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003228"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000010">
        <property type="entry name" value="probable cationic amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF4">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="7">
        <location>
            <begin position="565"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003228-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="680" mass="72740" checksum="D2838C1FB6E7F890" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P939</accession>
    <name>A0A182P939_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P939"/>
    <dbReference type="STRING" id="199890.A0A182P939"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003443-RA">
        <property type="protein sequence ID" value="AEPI003443-PA"/>
        <property type="gene ID" value="AEPI003443"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003443"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17340">
        <property type="entry name" value="MFS_MFSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="27">
        <location>
            <begin position="67"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003443-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="537" mass="59400" checksum="311C533FFE227C1F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PA47</accession>
    <name>A0A182PA47_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PA47"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003801-RA">
        <property type="protein sequence ID" value="AEPI003801-PA"/>
        <property type="gene ID" value="AEPI003801"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003801"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF3">
        <property type="entry name" value="AT07710P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131163" description="Amidase domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1067"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1153"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1194"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1219"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1259"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1296"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1337"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1378"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1401"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1509"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="63"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="596"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="1085"/>
            <end position="1432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003801-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1549" mass="170160" checksum="42B4FC0554C411F5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAW8</accession>
    <name>A0A182PAW8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PAW8"/>
    <dbReference type="STRING" id="199890.A0A182PAW8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004073-RA">
        <property type="protein sequence ID" value="AEPI004073-PA"/>
        <property type="gene ID" value="AEPI004073"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004073"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13990">
        <property type="entry name" value="STKc_TLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000037">
        <property type="entry name" value="Serine/threonine-protein kinase tousled-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF23">
        <property type="entry name" value="TOUSLED-LIKE KINASE, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
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            <end position="1061"/>
        </location>
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    </feature>
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            <begin position="612"/>
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    </feature>
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            <end position="767"/>
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        </location>
    </feature>
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        </location>
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        </location>
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            <end position="307"/>
        </location>
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        </location>
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        </location>
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            <begin position="1089"/>
            <end position="1115"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <position position="811"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004073-PA"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1136" mass="119350" checksum="EFE25B28873B7EAB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAX2</accession>
    <name>A0A182PAX2_9DIPT</name>
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        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000075885">
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    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR11324:SF16">
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    </dbReference>
    <dbReference type="Pfam" id="PF00595">
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    </dbReference>
    <dbReference type="SMART" id="SM00228">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="864"/>
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        </location>
    </feature>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004077-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1171" mass="124855" checksum="8B0DC5A9CC1E1D5A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCA1</accession>
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            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
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        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
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            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="AlphaFoldDB" id="A0A182PCA1"/>
    <dbReference type="STRING" id="199890.A0A182PCA1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004556-RA">
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        <property type="gene ID" value="AEPI004556"/>
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    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16724">
        <property type="entry name" value="RING-HC_MIB1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16725">
        <property type="entry name" value="RING-HC_MIB1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16727">
        <property type="entry name" value="RING-HC_MIB1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02339">
        <property type="entry name" value="ZZ_Mind_bomb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000090">
        <property type="entry name" value="E3 ubiquitin-protein ligase MIB1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000083">
        <property type="entry name" value="E3 ubiquitin-protein ligase MIB1 isoform X1"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000085">
        <property type="entry name" value="E3 ubiquitin-protein ligase MIB1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative E3 ubiquitin-protein ligase mib1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="MIB1/2_ZZ"/>
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        <property type="entry name" value="Mib_Herc2"/>
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    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
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    <dbReference type="InterPro" id="IPR040847">
        <property type="entry name" value="SH3_15"/>
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    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="Znf_ZZ"/>
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        <property type="entry name" value="Znf_ZZ_sf"/>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB1"/>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
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        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00569">
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        <property type="entry name" value="ANK"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="20">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
            <begin position="102"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="20">
        <location>
            <begin position="165"/>
            <end position="243"/>
        </location>
    </feature>
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        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="537"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="570"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="603"/>
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        </location>
    </feature>
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        <location>
            <begin position="672"/>
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        </location>
    </feature>
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        <location>
            <begin position="706"/>
            <end position="738"/>
        </location>
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        <location>
            <begin position="945"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="992"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="1167"/>
            <end position="1200"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="836"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="861"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004556-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1210" mass="130293" checksum="D14CD04B8116796B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCC8</accession>
    <name>A0A182PCC8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="199890.A0A182PCC8"/>
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        <property type="protein sequence ID" value="AEPI004583-PA"/>
        <property type="gene ID" value="AEPI004583"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004583"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02901">
        <property type="entry name" value="Macro_Poa1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADP-ribose_metab_enzymes"/>
    </dbReference>
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        <property type="entry name" value="Macro_dom"/>
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    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521:SF0">
        <property type="entry name" value="ADP-RIBOSE GLYCOHYDROLASE OARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521">
        <property type="entry name" value="PROTEIN C6ORF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004583-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="148" mass="16194" checksum="2A47E9F4AF37C3E7" modified="2016-09-07" version="1">MASCVREIEGDLFSAPKDHSLAHCVAADLKMGAGIAVRFKQLYGKVDELKAQNVNVGGVAVLADAPPRYVYYLITKKTYNLKPTYDDLTKSLQAMKEHMAKNGVGKLAIPRIGCGIDGLEWGKVKSILNTVFGEDGLFEIVVYNYVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCN0</accession>
    <name>A0A182PCN0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Nitric oxide synthase</fullName>
            <ecNumber evidence="3 14">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Produces nitric oxide (NO) which is a messenger molecule with diverse functions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O</text>
            <dbReference type="Rhea" id="RHEA:19897"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Binds 1 FAD.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="14">Binds 1 FMN.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the NOS family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="3 14"/>
    <dbReference type="AlphaFoldDB" id="A0A182PCN0"/>
    <dbReference type="STRING" id="199890.A0A182PCN0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004685-RA">
        <property type="protein sequence ID" value="AEPI004685-PA"/>
        <property type="gene ID" value="AEPI004685"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004685"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903522">
        <property type="term" value="P:regulation of blood circulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00795">
        <property type="entry name" value="NOS_oxygenase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.440.10:FF:000001">
        <property type="entry name" value="Endothelial nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000002">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000033">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000003">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012144">
        <property type="entry name" value="NOS_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000333">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60001">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 14" id="KW-0288">FMN</keyword>
    <keyword evidence="4 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="12 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0521">NADP</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="16">
        <location>
            <begin position="394"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="622"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000333-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004685-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1074" mass="122581" checksum="C8A78180CFCCEA5C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDR4</accession>
    <name>A0A182PDR4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDR4"/>
    <dbReference type="STRING" id="199890.A0A182PDR4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005069-RA">
        <property type="protein sequence ID" value="AEPI005069-PA"/>
        <property type="gene ID" value="AEPI005069"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005069"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007614">
        <property type="entry name" value="Retinin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34931">
        <property type="entry name" value="FI02976P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34931:SF3">
        <property type="entry name" value="FI02976P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04527">
        <property type="entry name" value="Retinin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131189" evidence="1">
        <location>
            <begin position="17"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005069-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="194" mass="20095" checksum="AAD3A3A1BC18BCCA" modified="2016-09-07" version="1">MFRLVVLSALLAVAAAAPGVSLVHSSPLAYSTVVAAAPTLVAQKEISYQKSIVEEPTVAHVGTVVKNVPTGVTHTSSAVVHDTKVRENVYAPAVKKTVVSTPVEKTTYVQAATPVVHAAPAVYAAPVQTVYAAPVAKTYSYAAPVAKTYVQAAAPAAISYEAAPLAYAAPLKTSYVSSYPSVYAAPAVYANQWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDW5</accession>
    <name>A0A182PDW5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PDW5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005120-RA">
        <property type="protein sequence ID" value="AEPI005120-PA"/>
        <property type="gene ID" value="AEPI005120"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005120"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131254" evidence="2">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005120-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="208" mass="23929" checksum="D751F2354EC22106" modified="2016-09-07" version="1">MKLVVLLLGVVFLAAITHGYPVGCEDEPELPPPIAEDQPTVNMEVVKVVGMQDAQSVTSEDSYDTKDSYPSYRYGFRPSYASDDEPADDDEDEEDPYQELFMNAYRSAPQSSDEDEDTTQEGMSKFCNPDAKPLSLMEDWDLWDYMDESELKERLRDHPRLLEEITRKRKRRLLEEEDGTRAREDDELCDVMNRAVKCIRTEPPSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDW9</accession>
    <name>A0A182PDW9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tektin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PDW9"/>
    <dbReference type="STRING" id="199890.A0A182PDW9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005124-RA">
        <property type="protein sequence ID" value="AEPI005124-PA"/>
        <property type="gene ID" value="AEPI005124"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005124"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF12">
        <property type="entry name" value="TEKTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005124-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="486" mass="55450" checksum="6B8BF93DDD957182" modified="2016-09-07" version="1">MAQLNCPPCTPCASVCIEHQPIQTLFTSPVGLPASDPPPYLPQRAGNSDGYPLAKAMGPIGPWATGRVDWGALSGQTGTRPVVNQYSITRYSVDEWRQRNADTINACETTVDNSVQVENSSKNTIIRTYAIADKTQTDCTQSLHVRAKNIDNLKCELDRAISSMQEEIAALERQRRRLKQSLAVLRMPEAIANECLERRTGRPDTELIRDRPEEELIQEISLISEIKAILLQTLANIEQQQSDNRAVRQRMEFDWSEKKVAHENDAVNCNLRNQSTNTLFKPGATRCSNEQSTEIYWEKFTRETLDMFHNCRHKSEQLRNTLDAILTNAARDLRTQADSVERALATRISCMEEIREKMEIDLRTVLQRLADTEIQIDKLKVAIRNMDYAMMVVQTRLDNRNQRPRVENCRDQPQNLLIAEVKSLEVGTSSMNAQLKQEEDVKQELINRRNELEREIMLNLPAIAIDRDRCQLLRSHFPSSTALSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE32</accession>
    <name>A0A182PE32_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PE32"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005187-RA">
        <property type="protein sequence ID" value="AEPI005187-PA"/>
        <property type="gene ID" value="AEPI005187"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005187"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17335">
        <property type="entry name" value="MFS_MFSD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000487">
        <property type="entry name" value="monocarboxylate transporter 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000488">
        <property type="entry name" value="MonoCarboxylate Transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="864"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="987"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1028"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1176"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1208"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1238"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1301"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="801"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1385"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005187-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1412" mass="154355" checksum="713764DD0722C196" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEK9</accession>
    <name>A0A182PEK9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PEK9"/>
    <dbReference type="STRING" id="199890.A0A182PEK9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005364-RA">
        <property type="protein sequence ID" value="AEPI005364-PA"/>
        <property type="gene ID" value="AEPI005364"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005364"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021859">
        <property type="entry name" value="XTBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XTBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51827">
        <property type="entry name" value="XTBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XRN2-binding (XTBD)" evidence="2">
        <location>
            <begin position="72"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="1">
        <location>
            <begin position="307"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005364-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="53618" checksum="CA0AE5E3BDBAC90D" modified="2016-09-07" version="1">MNLESNRLNRVTSLPTKTIKNQNKRKRFNRFYRRKNSKYIATLPLSTILAGICPEIPAELPVPPVVGTNWEIEAHRKPYDTDSQWYLKQWFMELHKDNIPEDELVPLAQAFASMEGLGCTYAPELMDRVLQLGEPVSRYYRDLKQQQCSRTLVSSQEAVRMWLNGITYAEEQEGKRQMQIAQISPICPPQSLAEVFQNIIVVNNSLQETAEWFEWLGGGTITITVNPISCVVFEVKAYAANFFISKASGSYQKAYAQCVADFLEILKNYCYQVNYIQRFSHLHYNVERLLNEDDQQQNSPGRFSLKQNNIGYRMLQKLGWTGGPLGYKQSGILNPIEVAAKHDRRGLGCTKGKKKKQMENVDASHCELDLQFYHELMLSIVARKPYYDLIFSPEFTENERIILTRLAAQQELRCETRLTGNGQAQFVIKRYPLPPHKILAEVLIEQHPIVSKYYQVLPPKVGLIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF37</accession>
    <name>A0A182PF37_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PF37"/>
    <dbReference type="STRING" id="199890.A0A182PF37"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005542-RA">
        <property type="protein sequence ID" value="AEPI005542-PA"/>
        <property type="gene ID" value="AEPI005542"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005542"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005542-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="64041" checksum="7C1BC3E2A6C68154" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFR0</accession>
    <name>A0A182PFR0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IkappaB kinase</fullName>
            <ecNumber evidence="3">2.7.11.10</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19073"/>
            <dbReference type="Rhea" id="RHEA-COMP:13698"/>
            <dbReference type="Rhea" id="RHEA-COMP:13699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.10" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PFR0"/>
    <dbReference type="STRING" id="199890.A0A182PFR0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005767-RA">
        <property type="protein sequence ID" value="AEPI005767-PA"/>
        <property type="gene ID" value="AEPI005767"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005767"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008385">
        <property type="term" value="C:IkappaB kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008384">
        <property type="term" value="F:IkappaB kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000147">
        <property type="entry name" value="Inhibitor of nuclear factor kappa-B kinase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046375">
        <property type="entry name" value="IKBKB_SDD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051180">
        <property type="entry name" value="IKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969">
        <property type="entry name" value="IKB KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969:SF17">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="14"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="741"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="648"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005767-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="808" mass="92958" checksum="B901001AEA0613B0" modified="2019-01-16" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PG66</accession>
    <name>A0A182PG66_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PG66"/>
    <dbReference type="STRING" id="199890.A0A182PG66"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005925-RA">
        <property type="protein sequence ID" value="AEPI005925-PA"/>
        <property type="gene ID" value="AEPI005925"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005925"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22761">
        <property type="entry name" value="OTU_OTUD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000003">
        <property type="entry name" value="OTU domain-containing protein 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049772">
        <property type="entry name" value="OTU_OTUD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="151"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005925-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="299" mass="34161" checksum="E4AE02D3D6F77A7D" modified="2016-09-07" version="1">MSDPLPESADREEVMARHRKEKKELQCKIQSMKKMKVDKKKKKEIQEEIANLELEIEQRHAEELNRLNLSGPPEPAETAIEAPAAENGEDGNEESKQETRLSKAQRRRDKKAQDNREREEQIKQEAALLQKSSPRVLEDNRINALLLKRGMLSHAVPADGDCLYTAINHQLVQRGIGSYSVPELRRITADYIEANRDTLICYMSHPDTGDMLTEEEFDKYCRQVRATKAWGGEIEIKALSTSLKCPIEVIQAEGPSTVHGVEGEGEERKLVLTYHRHMYRLGEHYNSTKPIPVHSTDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGA9</accession>
    <name>A0A182PGA9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PGA9"/>
    <dbReference type="STRING" id="199890.A0A182PGA9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005968-RA">
        <property type="protein sequence ID" value="AEPI005968-PA"/>
        <property type="gene ID" value="AEPI005968"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005968"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004097">
        <property type="term" value="F:catechol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1520:FF:000001">
        <property type="entry name" value="Hemocyanin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF24">
        <property type="entry name" value="GH04080P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="10">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005968-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="686" mass="78539" checksum="416678D2C7F5C8C6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGD1</accession>
    <name>A0A182PGD1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGD1"/>
    <dbReference type="STRING" id="199890.A0A182PGD1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005990-RA">
        <property type="protein sequence ID" value="AEPI005990-PA"/>
        <property type="gene ID" value="AEPI005990"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005990"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900271">
        <property type="term" value="P:regulation of long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099509">
        <property type="term" value="P:regulation of presynaptic cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000262">
        <property type="entry name" value="calbindin-32 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051001">
        <property type="entry name" value="Calbindin_Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972">
        <property type="entry name" value="CALBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972:SF10">
        <property type="entry name" value="CALBINDIN-32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005990-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="90" mass="10275" checksum="21197471DD38FA09" modified="2016-09-07" version="1">GAAKLTKEDIEKVFSLYDRDNNGSIENEELRGFLKDLLELVKKDYDAQDLIEFEETILRGVGYDKDGKISRKELTMILLALAKLPPDDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGH2</accession>
    <name>A0A182PGH2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGH2"/>
    <dbReference type="STRING" id="199890.A0A182PGH2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006031-RA">
        <property type="protein sequence ID" value="AEPI006031-PA"/>
        <property type="gene ID" value="AEPI006031"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006031"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006031-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="168" mass="17730" checksum="A0916C59BBE2E4FF" modified="2016-09-07" version="1">MGRDTSAFLHHEQGMPEFPLALPLPHNIPHPALPTEFWPPNFGLHPSLLPATHGLLHPNVMPNYKIPNFHAILSQYMGLNNLFGGYPQNLSVNTRISPQNSPKQSPTSVPATMVGGPVGLNNTSNSSANSGILSSSSSNSSSSSSSSSSSNISVGSNSNTSKECIVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH39</accession>
    <name>A0A182PH39_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PH39"/>
    <dbReference type="STRING" id="199890.A0A182PH39"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006248-RA">
        <property type="protein sequence ID" value="AEPI006248-PA"/>
        <property type="gene ID" value="AEPI006248"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006248"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="158"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="239"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="312"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="386"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006248-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="594" mass="66688" checksum="2D5AF0C3A6B2D0EC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH76</accession>
    <name>A0A182PH76_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PH76"/>
    <dbReference type="STRING" id="199890.A0A182PH76"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006285-RA">
        <property type="protein sequence ID" value="AEPI006285-PA"/>
        <property type="gene ID" value="AEPI006285"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006285"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058698">
        <property type="entry name" value="CUB_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236:SF12">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26080">
        <property type="entry name" value="CUB_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="8"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006285-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="317" mass="34530" checksum="9A8C15547C606ACB" modified="2016-09-07" version="1">MIGPTLACGGTSLVKSTTLLTPNNIAANGLTCVYTIRALNLRICQLRLDFNSFSLAQPTLDPYPRCINDVFSVDNLNFDLCGENSGQHVYVPFNPTSADRTMTITFRIASRSQIPTLANPHWSVRVQQLECPSGMAVAAKDAARHLETPDMLPPLARTLHGDIGLLAPTGCLQYFQDTSGTVESFNFGNGAGPYLGAMNYAICFHRSRNSNALRVIPMTFEIASSATPTAQNPGVDELCYSSIASPGRSEDNLQIPNAVARLPTLPSLRATRFCSTSLANGDVEVSGPGPFIMYFQSDQLFDPFRRETGFRFQYTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHP2</accession>
    <name>A0A182PHP2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHP2"/>
    <dbReference type="STRING" id="199890.A0A182PHP2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006452-RA">
        <property type="protein sequence ID" value="AEPI006452-PA"/>
        <property type="gene ID" value="AEPI006452"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006452"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF136">
        <property type="entry name" value="GH06673P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006452-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
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    </evidence>
    <sequence length="301" mass="31981" checksum="7701055A7BC21B40" modified="2016-09-07" version="1">MKTFVVLLALAAVAANAEWIDIDWSKVRPIEDFDHYWERLPAELQIYRHVRPSHRVTNGQEATPGQFPYQVALLSEFVITSGLCGGSVLTNNFILTAAHCVVGTAGILASGGTAIMGAHNRNIQEPSQQRIRFSGPGVIPHPFYASSNLRNDIALVRLDAPIVFNDRVQPVRLPARSDTRQFGGSLGTVSGFGRTSDASTATSPVVMFTTNPVMTNADCIARWNTALIEPQNVCLSGEGGRSACNGDSGGPLAVQDGGSLQIGVVSFGSAGGCTVGMPSVYARVSFFLPWIEANSDFVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI30</accession>
    <name>A0A182PI30_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AEPI006592"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006592-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="65" mass="7000" checksum="51355EBE2DDEDC1F" modified="2016-09-07" version="1">IGFSTGSDHVNSSVSIVNSISSARIAQIIETDPDDDSFRLRITWSKPTSANYSKTAGGCDSERYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI77</accession>
    <name>A0A182PI77_9DIPT</name>
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        <recommendedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase RBBP6</fullName>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="AEPI006639"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase RBBP6 isoform X2"/>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCHC-type"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="DWNN_domain"/>
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        <property type="entry name" value="RBBP6"/>
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        <property type="entry name" value="Znf_CCHC"/>
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    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
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    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
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        <location>
            <begin position="1974"/>
            <end position="1997"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006639-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1997" mass="224593" checksum="D1DBD341638324FA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PI88</accession>
    <name>A0A182PI88_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase</fullName>
            <ecNumber evidence="3">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
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        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavin monoamine oxidase family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A182PI88"/>
    <dbReference type="STRING" id="199890.A0A182PI88"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006650-RA">
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        <property type="gene ID" value="AEPI006650"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006650"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046592">
        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF398">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="469"/>
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            <end position="900"/>
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        <location>
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            <end position="1071"/>
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    </feature>
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        <location>
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            <end position="987"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1029"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="945"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="972"/>
            <end position="987"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006650-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1076" mass="120066" checksum="FE11B8DE87EB0850" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIH1</accession>
    <name>A0A182PIH1_9DIPT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="EnsemblMetazoa" id="AEPI006733-RA">
        <property type="protein sequence ID" value="AEPI006733-PA"/>
        <property type="gene ID" value="AEPI006733"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006733"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="1423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006733-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1502" mass="164787" checksum="9F6674E62CF6C6E2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJB2</accession>
    <name>A0A182PJB2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">sulfite oxidase</fullName>
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    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Energy metabolism; sulfur metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.8.3.1" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182PJB2"/>
    <dbReference type="STRING" id="199890.A0A182PJB2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007026-RA">
        <property type="protein sequence ID" value="AEPI007026-PA"/>
        <property type="gene ID" value="AEPI007026"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007026"/>
    <dbReference type="UniPathway" id="UPA00096"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02111">
        <property type="entry name" value="eukary_SO_Moco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.650:FF:000009">
        <property type="entry name" value="probable sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007026-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="512" mass="56635" checksum="029800117BB3E5F4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJY6</accession>
    <name>A0A182PJY6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cuticular protein RR family</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJY6"/>
    <dbReference type="STRING" id="199890.A0A182PJY6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007252-RA">
        <property type="protein sequence ID" value="AEPI007252-PA"/>
        <property type="gene ID" value="AEPI007252"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007252"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF18">
        <property type="entry name" value="CUTICULAR PROTEIN 66D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131373" description="Cuticular protein RR family" evidence="4">
        <location>
            <begin position="18"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007252-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29938" checksum="E19994875BA2AEC7" modified="2016-09-07" version="1">MRAFVVASILCVGFVSAYPQQAVDPAYLRQYYQQIAQAAGAQNAAQGRADPTPIFEQGAQEQQHIPQYVTQGQQLRVKDNVQEQIRHQYQQPQARQYQPQYQPQQIQYVQEQQYQQPQPQLKVSKPRPQYLQGGQKQQLEEDQEDYDPNPSYQFGFDVKDDEFTNYQNRKEQRDGNVIKGSYSVVDSDGFIRTVTYTADPKEGFKAEVSRQPTDIVVKIPTPAPQSAGHHQSAGAYRVQQQQPQQQAQPRPRPQEYSQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK15</accession>
    <name>A0A182PK15_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PK15"/>
    <dbReference type="STRING" id="199890.A0A182PK15"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007281-RA">
        <property type="protein sequence ID" value="AEPI007281-PA"/>
        <property type="gene ID" value="AEPI007281"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007281"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF44">
        <property type="entry name" value="PROTEIN LAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007281-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="7206" checksum="B77D950DA103C765" modified="2016-09-07" version="1">MFKYIPIFKGCNRQIEYVDNRHSSLPNVPEEIFRYSNSLEELLLDANHIRDLPKIKQIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKR6</accession>
    <name>A0A182PKR6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKR6"/>
    <dbReference type="STRING" id="199890.A0A182PKR6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007533-RA">
        <property type="protein sequence ID" value="AEPI007533-PA"/>
        <property type="gene ID" value="AEPI007533"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007533"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_A">
        <property type="entry name" value="Ribosomal_uL2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="9">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="8">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007533-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="261" mass="28769" checksum="AF1338060639AB23" modified="2016-09-07" version="1">MGRVIRAQRKGAGSVFRAHTKKRKGQPKLRHLDYAERHGYLKGVVKQIIHDPGRGAPLAVVNFRDPYRFRLNKQLFIAAEGMYTGQFVYCGRRAQLQIGNVLPIGLMPEGTIVCNLEEKTGDRGKLARTSGNYASVIAHNPDTKRTRVKLPSGAKKVLPSANRAMVGIVAGGGRIDKPILKAGRAYHKYKVKRNCWPKVRGVAMNPVEHPHGGGNHQHIGKASTVKRGTPPGRKVGLIAARRTGRIRGGKGDEKFKEKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLB5</accession>
    <name>A0A182PLB5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Actin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PLB5"/>
    <dbReference type="STRING" id="199890.A0A182PLB5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007732-RA">
        <property type="protein sequence ID" value="AEPI007732-PA"/>
        <property type="gene ID" value="AEPI007732"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007732"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007732-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41645" checksum="88726679B8B03DE0" modified="2016-09-07" version="1">MCDDDAAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETVYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSSIKIKIIAPPERKYSVWIGGSILASLSTFQAMWISKQEYDESGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLC0</accession>
    <name>A0A182PLC0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLC0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007738-RA">
        <property type="protein sequence ID" value="AEPI007738-PA"/>
        <property type="gene ID" value="AEPI007738"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007738"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007738-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="335" mass="34592" checksum="36A7F670F228BA0A" modified="2016-09-07" version="1">MADQGQCPPITSAPKRSTDHPQTSVGMPAPLHHLHGSESCKNSPNVPRRHADPAHHLPHHAAGLLLLESGSQSAKSSPLPNRRLDKLQGVIRDQRSTPIAGRRATEDCEMEAFDSPLVSRRFLQQQQPCECVRGAAAPPAKRRAASECACGTGAESQVMRKRVDSDCGSASSSSCLRKNVVRHNFGLASGGGLSSCENSPLPVRRQFGAAGGGGPAFPVSPAKSVLGEPGVFSSPIHRPYHHAVAAGFHGPAGGSPAKSVLGEPGVFSSPARSVVCSPPGNGEPRSVGGGVGEGIEDMDIGVGGSGAGDVLAGDQTIVSGWLKFRDNKKVSEMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLE2</accession>
    <name>A0A182PLE2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A182PLE2"/>
    <dbReference type="STRING" id="199890.A0A182PLE2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007760-RA">
        <property type="protein sequence ID" value="AEPI007760-PA"/>
        <property type="gene ID" value="AEPI007760"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007760"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131481" description="Carbohydrate sulfotransferase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007760-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="330" mass="38799" checksum="F8C5D23FD1A05E03" modified="2016-09-07" version="1">MCVTWKTVMFFASLLACTESRYDWPTEDVSHSILTSGYKEYEYELTQAHNLYRQDVLQKSCQYNITDDMTERLEKLNQLRTDHLLVDREHKFLYCYVPKVACTNWKRVMMILMSKWNGTDPLQIPADLAHSSGMFETFESLTDEEKIAVLSDYHRFVLVRHPFERLLSAFRNKLEGNSKSAKYFQARIGRTIIKSFRLHATNESLANADDVQFYEFVQFLLTPELSKNGNASFNEHWEPISRLCHPCLVHYNVIGKYETLTDDSSLALHLAGADELSFPMVYKSASTREHLMHYFNDIPPETLKRLYLLYEEDFRNFDYSLEEIFGYELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLY8</accession>
    <name>A0A182PLY8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLY8"/>
    <dbReference type="STRING" id="199890.A0A182PLY8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007960-RA">
        <property type="protein sequence ID" value="AEPI007960-PA"/>
        <property type="gene ID" value="AEPI007960"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007960"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000068">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF18">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007960-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="126" mass="14134" checksum="3E4252237604C335" modified="2016-09-07" version="1">MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERTMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNESDMKFYAAEVSDTVGRGHSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM73</accession>
    <name>A0A182PM73_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PM73"/>
    <dbReference type="STRING" id="199890.A0A182PM73"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008046-RA">
        <property type="protein sequence ID" value="AEPI008046-PA"/>
        <property type="gene ID" value="AEPI008046"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008046"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019871">
        <property type="term" value="F:sodium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048814">
        <property type="term" value="P:regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04033">
        <property type="entry name" value="C2_NEDD4_NEDD4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000289">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000037">
        <property type="entry name" value="E3 ubiquitin-protein ligase nedd-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="11"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="499"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="558"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="650"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="272"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008046-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="961" mass="106753" checksum="512BE3A106C72F72" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMC3</accession>
    <name>A0A182PMC3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein phosphatase 1 regulatory subunit 14B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP1 inhibitor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMC3"/>
    <dbReference type="STRING" id="199890.A0A182PMC3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008096-RA">
        <property type="protein sequence ID" value="AEPI008096-PA"/>
        <property type="gene ID" value="AEPI008096"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008096"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.220:FF:000004">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.220">
        <property type="entry name" value="CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008025">
        <property type="entry name" value="CPI-17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036658">
        <property type="entry name" value="CPI-17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188:SF14">
        <property type="entry name" value="GEO07393P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05361">
        <property type="entry name" value="PP1_inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81790">
        <property type="entry name" value="Myosin phosphatase inhibitor 17kDa protein, CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008096-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13944" checksum="05AA44AA9E1C735A" modified="2016-09-07" version="1">MQCGVETMNDCERSPGRTGLRVNFTEKGEVKERREKFLTAKYGSHQMSLIRKRLAVEMWLYDELQKLFDPPTEAIDVDIDEILDMDTDDIRRSHLFSLLSACKRPPQDISINDPLGQGWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMU7</accession>
    <name>A0A182PMU7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PMU7"/>
    <dbReference type="STRING" id="199890.A0A182PMU7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008271-RA">
        <property type="protein sequence ID" value="AEPI008271-PA"/>
        <property type="gene ID" value="AEPI008271"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008271"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03716">
        <property type="entry name" value="SOCS_ASB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="696"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008271-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="749" mass="83454" checksum="475010BC82FF0E11" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMY1</accession>
    <name>A0A182PMY1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PMY1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008305-RA">
        <property type="protein sequence ID" value="AEPI008305-PA"/>
        <property type="gene ID" value="AEPI008305"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008305"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008305-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="118" mass="14354" checksum="52FFCA83C41C3BA6" modified="2016-09-07" version="1">MNPTVRLQYIRYLALKKPPNERISACFKQFFSPWSLYNFNWQKTADPDRRKQSMREFKLFTECMIEAWSSSHELDEAQLFAELQIALTEAHESINQSHYKRRKRSEMIQMMLRQKFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNP0</accession>
    <name>A0A182PNP0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PNP0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008567-RA">
        <property type="protein sequence ID" value="AEPI008567-PA"/>
        <property type="gene ID" value="AEPI008567"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008567"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008567-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="270" mass="28707" checksum="79C189DE3505AF1C" modified="2016-09-07" version="1">MADGLLQRFSTIGGVISSSSTSVPPMDTASITQRIHHEPPPALLANGKYPVYGPGTGPDLYDDEANEFWHGTEANAGAGFFPSFLPWGPAPQGTHPVPPPLPPPPPPPPPPAYPLYRGPYGGPLYKGLRFKGASVAVLTLLAFLFFLSILQNYIRDYSATSQPTVILLSAGATKENALPLYPYRVRQKIGQRGDEPPRFDDDDDADAIEDTVDQGEGTTTGGYRARIRKGTVQHRTHHKSGGAGGKMSPGSVPTVPSSAPLGDIFKVNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP17</accession>
    <name>A0A182PP17_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP17"/>
    <dbReference type="STRING" id="199890.A0A182PP17"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008696-RA">
        <property type="protein sequence ID" value="AEPI008696-PA"/>
        <property type="gene ID" value="AEPI008696"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008696"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000019">
        <property type="entry name" value="Ligand-dependent corepressor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF105">
        <property type="entry name" value="RIBBON, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="7">
        <location>
            <begin position="472"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="721"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
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        <location>
            <begin position="299"/>
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        </location>
    </feature>
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        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
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        <location>
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            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="795"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008696-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="855" mass="91117" checksum="4FCEB8DD4F5F231C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP18</accession>
    <name>A0A182PP18_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
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    <dbReference type="STRING" id="199890.A0A182PP18"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008697-RA">
        <property type="protein sequence ID" value="AEPI008697-PA"/>
        <property type="gene ID" value="AEPI008697"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008697"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
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        <property type="match status" value="2"/>
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        <property type="entry name" value="IMPORTIN_B_NT"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008697-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1130" mass="129401" checksum="F7EFD859D5B1F52C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP86</accession>
    <name>A0A182PP86_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adiponectin receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP86"/>
    <dbReference type="STRING" id="199890.A0A182PP86"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008765-RA">
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        <property type="gene ID" value="AEPI008765"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008765"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008765-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="48000" checksum="D5266FB63323CC26" modified="2016-09-07" version="1">MSSLRYEMDDDMQGGIKQQTASGSGLKSALNAAPGDELFNNMMAADFSIRKRRVWAPEEVSLASEDIDLLDDDDDLEEEEDDGVGCPLPSTPEDNQLLEAEMTEVLKAGVLSDEIDLGALAHNAAEQAEEFVRKVWEASWKVCHFKNLPAWLQDNDFLHKGHRPPLPSFGACFKSIFRIHTETGNIWTHLLGCVMFIGVAVYFLTRPAFEIQLQEKLIFLTFFIGAIICLGFSFAFHTLCCHSEMVGKLFSKLDYCGIALLIMGSFVPWLYYGFYCHYKHKLIYLTVVIVLGITSIITSLWDKFSQPNLRPLRAGVFMSFGLSGIIPAIHYVLMEGWFSKISQASLGWLILMGLLYILGALFYALRVPERWFPGKCDIWFQSHQIFHVLVLVAAFVHYHGISEMAMYRVTVGECDIPHQHPAISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPL0</accession>
    <name>A0A182PPL0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING finger and SPRY domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPL0"/>
    <dbReference type="STRING" id="199890.A0A182PPL0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008889-RA">
        <property type="protein sequence ID" value="AEPI008889-PA"/>
        <property type="gene ID" value="AEPI008889"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008889"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF6">
        <property type="entry name" value="RING FINGER AND SPRY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="279"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="509"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="554"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008889-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="65612" checksum="E9EB6448952DC3D8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPP0</accession>
    <name>A0A182PPP0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Scavenger receptor class B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an olfactory role that is not restricted to pheromone sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPP0"/>
    <dbReference type="STRING" id="199890.A0A182PPP0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008919-RA">
        <property type="protein sequence ID" value="AEPI008919-PA"/>
        <property type="gene ID" value="AEPI008919"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008919"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF114">
        <property type="entry name" value="FI02050P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008919-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57159" checksum="BC8B660EE69CBA4D" modified="2016-09-07" version="1">MGCCSNWSPTAKRICALSSATGVCVFALVLGLIWPPLVWQIAKTEFVLEPGTEVYKNWIEPPIDTYLELYLWNWTNADAYRTEKPHLEQLGPYTFRERHERVNLEWHDNDTLTFQQRRIWHYEPEKSVGDYENDRVVTINPVLLTVGYALRDDPVFLFYVDGIITMNGLATTPFYDVLVREMIFEGYDDELLTSLLALIALLPEESRPPIDLPPYDRFGWFFGRNGSETYDGTFTIGTGKDSVHNTGVMRLWNGVSQTEYYPGECGRIRGTTGEVWPPWGPTLSHTPSNVSVFAPDVCSSVTLQYFEKMERYGIDGLRWIGNDRVFDNGVHYEETACQCTANDESCPVLDNGAMDVSKCKFGAPATVSFPHFYLANESYLEGVSGMKPDEKEHRFEMELEPYTGVPLGVRAQLQVNLDVKQYGMTLLKDIPEVMLPVLWFRQTASLTEELADDIKLILILPDVGVYVAYGLGALGVIGLILAVYFSVTRWKLESPPQPVDVKTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPU1</accession>
    <name>A0A182PPU1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Yellow protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPU1"/>
    <dbReference type="STRING" id="199890.A0A182PPU1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008971-RA">
        <property type="protein sequence ID" value="AEPI008971-PA"/>
        <property type="gene ID" value="AEPI008971"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008971"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF11">
        <property type="entry name" value="RH54244P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008971-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="51689" checksum="F4B6960DD20D2A93" modified="2016-09-07" version="1">MKLGVPNLVVLVIIPASLTLLPDIFCVKLKEKFKWREVSFSWPSEDAKQDALNSGKYIVHNNLPLGLERWRDKLFITVPRWKAGVAASLTYVNVSDVLSPDLRPYPGWDENELPTGTSWYFRNIQFYIILLQNSTLNVLLERNGASDAESNYLKNNATIISTFRVRADECDRLWVMDTGLADILGDAVQYAPPSLVLFDLYTDKLIRRHFFNSTLLKEDSFFANVIVDTERGDCDNAHAYIPDLGSYAVIVYSFADDRSWRVKHNFFHFDPLAGDYNIGGVNFQWTDGVFGMAVGKRLQDGSRPIYFHAFSSTKEFMVSNTVLQNESYAQSPQAYYDYKLLGDRGPNSQSSAEFYDSETGVIFYTQVNKDGVGCWNTIMPLNADTQGLVDSDSDALVFPNDLKVDNEGTLWVLSDRLPMFIFTSLDEQQYNYRILVGETREIIKARRIRDRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPZ2</accession>
    <name>A0A182PPZ2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPZ2"/>
    <dbReference type="STRING" id="199890.A0A182PPZ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009022-RA">
        <property type="protein sequence ID" value="AEPI009022-PA"/>
        <property type="gene ID" value="AEPI009022"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009022"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
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    </dbReference>
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        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="3">
        <location>
            <begin position="189"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="72"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="1">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009022-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="427" mass="49227" checksum="4BDF583BD9DCED3C" modified="2016-09-07" version="1">MLKATFALNANRRCLSSALYLTGDKAREQFAVLVPYLDFKHKLGDLERLKRNIRLRRNPLDCDNLIRQWELYRDVEKRKREIEQCRVELQKRIQQTTCPQEQQQLKARAILARDDLKMLKEQSYQVADAFIANNFLSIPNDLHEHTPDKEMKCIYEKPALANPANQSSNVDLAQEQLEEFGPACLYMTGDAAWMDLRLPMFCSELFRQNKCILFCNPDFVRSFLVEAAMVDKESLFLVREEDEPEDKVNLLHLCGGGSLLSFLGYFTKLSVFPSALPLRLVASGKRYHFERAQSNEVQVFGAHISAEGAEEMFDEMVQTARHFYDQLPVGYRVVQVAAPNLRPIESMRVDIELLDGRNQRYVKVGELGYYSDFLSKRIAFIYHEGKVQRFPHVIAGTVMSTLELIKLLLGNGITMQDLPKLNTFVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ59</accession>
    <name>A0A182PQ59_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cation-transporting P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PQ59"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009089-RA">
        <property type="protein sequence ID" value="AEPI009089-PA"/>
        <property type="gene ID" value="AEPI009089"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009089"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1232"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1318"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1351"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1387"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009089-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1438" mass="157931" checksum="547E3EA4E4E7CED7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQG2</accession>
    <name>A0A182PQG2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQG2"/>
    <dbReference type="STRING" id="199890.A0A182PQG2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009193-RA">
        <property type="protein sequence ID" value="AEPI009193-PA"/>
        <property type="gene ID" value="AEPI009193"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009193"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00435">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028784">
        <property type="entry name" value="BBS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032728">
        <property type="entry name" value="BBS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056419">
        <property type="entry name" value="GAE_BBS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14779">
        <property type="entry name" value="BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23304">
        <property type="entry name" value="GAE_BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="1">
        <location>
            <begin position="579"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009193-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="663" mass="73808" checksum="721A87F688B3910E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQT7</accession>
    <name>A0A182PQT7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQT7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009318-RA">
        <property type="protein sequence ID" value="AEPI009318-PA"/>
        <property type="gene ID" value="AEPI009318"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009318"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF58">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="162"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009318-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="422" mass="47800" checksum="83EC1009D08351E2" modified="2016-09-07" version="1">MSDTEEDSTCSDSWPITEDWLIEVLKKHHEVRSGIKITDFKVKQGCQDGVNNLSDILSVSVVYEFERDIEPGVSQSLDIVIKLLPQDPFSRYFVTEAQFDLREIKFYTSILPDLMAFQEQYIPKGVGSMVISVPTCFYTQYAPVGSNTTASLSSPDSTESILVLEDMRSLGYKGANFTTGLTLGQTEGAIRAIVTIHALSLGLKIKKKVDLNEKYPFLFQTTRATESYQQLVEQGMPQLTKFLEQKPGFENELKALSKIRPKTKFLIETLLQPIEPMGLITHTDFWCNNLLFRSEPDEERTDSCTILDWQMVTYSRPTNDLALLLISSIPSNTRRQHTSRLLDLYYGTLKSYCLKMDVDIEADLGYSRNKMDCEYRQSLLLALLLCIGSVDIAIGNAAAEQRLLDVLRDFYEEGILSLEGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQY6</accession>
    <name>A0A182PQY6_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQY6"/>
    <dbReference type="STRING" id="199890.A0A182PQY6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009367-RA">
        <property type="protein sequence ID" value="AEPI009367-PA"/>
        <property type="gene ID" value="AEPI009367"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009367"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10319">
        <property type="entry name" value="EphR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000089">
        <property type="entry name" value="Eph receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001638">
        <property type="entry name" value="Eph receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001644">
        <property type="entry name" value="Eph receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1770:FF:000005">
        <property type="entry name" value="Eph receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1770">
        <property type="entry name" value="ephrin a2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001426">
        <property type="entry name" value="Tyr_kinase_rcpt_V_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF14">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25599">
        <property type="entry name" value="Ephrin_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00790">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Eph LBD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="278"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="437"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="698"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009367-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="755" mass="82302" checksum="1A069B02598277FE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRC7</accession>
    <name>A0A182PRC7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRC7"/>
    <dbReference type="STRING" id="199890.A0A182PRC7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009511-RA">
        <property type="protein sequence ID" value="AEPI009511-PA"/>
        <property type="gene ID" value="AEPI009511"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009511"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009511-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="110" mass="10699" checksum="914859085CC1743E" modified="2016-09-07" version="1">MYRSQATFSTEGVCGCGECATSSGGGGGGGVIPSGSGGGSTVATSGAMGAPSNGSKTAHSKVATGGGHANTQTSSKRSSSGADGDYQLVQHEVLYSLSAQYETKMPRNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRF9</accession>
    <name>A0A182PRF9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin interacting protein 3-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRF9"/>
    <dbReference type="STRING" id="199890.A0A182PRF9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009543-RA">
        <property type="protein sequence ID" value="AEPI009543-PA"/>
        <property type="gene ID" value="AEPI009543"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009543"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Actin interacting protein 3-like C-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009543-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="254" mass="29432" checksum="33F1C819B4FA396D" modified="2016-09-07" version="1">MLQYQAQTQPPNIQRSLDFETPQMRVYTPTNQGPLFDDDPGIMSEAETASTGFRRGGKQRSSLPVVRTPSKTLERPLGLVFLQYRSETKRALLPNEITSIDTVRALFVRSFPRQLTMQYLEGPNVKIYIHDSSKDMFYELEDVRSHLREIRDRSVLRLFESNEVSAPQVLPGGQNIPQPLQPAAIPNQWDQEQVTKHSYFSEPEFDSEYQHQHIHKSKVSHAVIDGIIHLFPFFAIHHLYILLTLGLWLHKIHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRK4</accession>
    <name>A0A182PRK4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein axonemal assembly factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cilium-specific protein required for cilia structures.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PRK4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009588-RA">
        <property type="protein sequence ID" value="AEPI009588-PA"/>
        <property type="gene ID" value="AEPI009588"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009588"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF8">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="745"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="841"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="949"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="983"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="772"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="806"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1001"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1056"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009588-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1452" mass="152239" checksum="F569B1917733DBC3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRS8</accession>
    <name>A0A182PRS8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PRS8"/>
    <dbReference type="STRING" id="199890.A0A182PRS8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009663-RA">
        <property type="protein sequence ID" value="AEPI009663-PA"/>
        <property type="gene ID" value="AEPI009663"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009663"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0222">Digestion</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="38"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="309"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="525"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009663-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="762" mass="81057" checksum="E756E26214A47925" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PT13</accession>
    <name>A0A182PT13_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PT13"/>
    <dbReference type="STRING" id="199890.A0A182PT13"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010099-RA">
        <property type="protein sequence ID" value="AEPI010099-PA"/>
        <property type="gene ID" value="AEPI010099"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010099"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000017">
        <property type="entry name" value="Golgi resident protein GCP60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052269">
        <property type="entry name" value="Golgi-PI4KB_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973:SF12">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13897">
        <property type="entry name" value="GOLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="36"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="315"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="141"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010099-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="480" mass="53860" checksum="E3CEADBFB060B53C" modified="2016-09-07" version="1">MVGGDSLDLSFKDLSIDGGTVSDGDSSKILKWNLPLKELYKLACSFYKEKSGKAIHLSYEDNLKLVAFTQQAAHGPLDLSKAPPLGMFDVIGKDRRIAWQQLGTITKLQAMEGFIDLLDRLCPLFKPYVEAIKKDREERARRAEQEEIARTAALAAEKERQEELQRLESEKNREELHRRQLQDALNQQTYHQFKEYAEIQFPGNPEQQAVLIRQLQNEHYHQYMQQLQAQVATNLARLKTGASDGEDDDNPTAVVCEQGGAGPNDTTEFPSAANGAAHNAKENSQFEFKEQCDSDNDSGDYAVISPANMWTKPDIKLFKQEVMAGKGDGVIRVNHGDTVTVKVPTHEGGSCLFWEFATDSYDIGFGVYFEWGKPPTTEVSVHISESDEDDDTIEEDDEVICAEDLECGPLQSGQTGGAGSALGSRNPISIIIPIYRRECHQEVYAGSHTYPGEGTYLLKFDNSYSLWRPKTLYYKVFYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTE4</accession>
    <name>A0A182PTE4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTE4"/>
    <dbReference type="STRING" id="199890.A0A182PTE4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010230-RA">
        <property type="protein sequence ID" value="AEPI010230-PA"/>
        <property type="gene ID" value="AEPI010230"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010230"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007100">
        <property type="term" value="P:mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="10">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="408"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010230-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="506" mass="56154" checksum="0A3E39E1F3FE7B30" modified="2016-09-07" version="1">MEDKLFTSVEEECLYWKERCLKVSQERDDAQREFDDFTTESRQLEAELEMTVEQQEKKIRDLNQLVNQLHGENESYKRKMQYTENETNKIDADFRQLAKENEKLKVYIRELEQKNDDLERANRVASESVAEFESMLNQAYEKNALLELEVDEKERMQIKLQRLMDEARDLKQELKVRTLKPDEHGEKLEDEEVLAENGDKQLEPSNENAPSTTTTIATAVTSAHGTQPLNSVCLGDGIDPEEGGGTKLETLNNNLNTSKQRSALVSPMVKLSSSKLNDYGRETEQDGNKTLDGMVGDGVKGTLLLSSPSSQLIIERNGNSASSTALVPGGMGNLNAPMAPSDRVSTLNIVADLLQRLDNMEAKLKAWKIRKPSSRTTGPPGSATGSVGSNRTSLHTSHTISNLHHSMNSNHQHQQHHHHHSNNHHHYQSQLQHHNHADSNLSLNSLGSGDGTLLLGSSANCCSGTGGSSNTVGGGNVQLHSYQPSTITIGTQTSQPTKTELLRMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTQ4</accession>
    <name>A0A182PTQ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell morphogenesis protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182PTQ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010340-RA">
        <property type="protein sequence ID" value="AEPI010340-PA"/>
        <property type="gene ID" value="AEPI010340"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010340"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="266"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="901"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="804"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010340-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1499" mass="164118" checksum="AF2082E8C3DF3DE7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTT5</accession>
    <name>A0A182PTT5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PTT5"/>
    <dbReference type="STRING" id="199890.A0A182PTT5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010371-RA">
        <property type="protein sequence ID" value="AEPI010371-PA"/>
        <property type="gene ID" value="AEPI010371"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010371"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF104">
        <property type="entry name" value="AGAP010328-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131893" description="Lipase domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010371-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41066" checksum="18D4ECE5B79F6FD3" modified="2016-09-07" version="1">MFVRQCAERLLLPVAVGLLLVLVQQTDPVSADRYQDNIFFNYYNSSGDLVHIFNLAENNTYEYDKDCRPGSKYAVVVFGWKIDCEKYFVKDLIGNLTKHRGGCVMCMNYDRFAQLPTYARLRRNFKDIHGVLKQKLEFLEQEGFSPDDAYLYGFSFGAQLVLAAAKDYGTRKIKEIDLCDIVGTGFDTSDVNAPNHRTAAKNVQCIHTSRNYGTRHRTSCHQDWIMGDCGINQLAAPLSPWGSHGVCTLLYNSAFEHDFLARAKPANCTGESEVRSWPDGFKMGYSEQRKTTVRGQLYAPTFAVFPFNVNVTASSNATTDSSATAPALGTNDIEQFPGFEFRSASNDDYLMDGEEDDDDDDAGSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTY3</accession>
    <name>A0A182PTY3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homolog subfamily C member 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Endoplasmic reticulum DNA J domain-containing protein 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in regulating the size of autophagosomes during the formation process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTY3"/>
    <dbReference type="STRING" id="199890.A0A182PTY3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010419-RA">
        <property type="protein sequence ID" value="AEPI010419-PA"/>
        <property type="gene ID" value="AEPI010419"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010419"/>
    <dbReference type="Proteomes" id="UP000075885">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052448">
        <property type="entry name" value="DnaJ_C16_autophagy_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043361">
        <property type="entry name" value="DNAJC16_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010419-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="456" mass="53520" checksum="232CDB7D1DB4218E" modified="2016-09-07" version="1">HPDKSKNPDAETRFVEIKQSYELLSDSERRRAYDQYGITNEDAVLDRNRPDYSNYGRFQDPFEHFYGAHNFNFHDQDISLYHRLSITTKYYETNILPKSRQTPQILMFYADWCFSCMKAANSFKKLIDTLEPYGIMFATVNAGHEEQLVRKVGAHSLPCVTMVLDGHNYVYKDSVFNIQHVVDFMRQKLPYKLLMPVTDNTLDNFLSGWSDNRVRVLILEPRTQPRLRYLIIAFHYRERIAFGFTQLDSKDTMNIQAKFKARPDLDTLLIFNEFPHQPIATVTMSDIPTTTLNNIISLNKYLILPRLSSQGMLESIVILWRRDTKHIRYEWINEIVLDKDNFMENDTHDQFFNKTKQKLDTVIQRLLRSTEALSYETVVKDLLDEHAENPIMRIFNRIILALEYVSDNLGQEHILPALSVVGTIVFILTIGYLMSYLLHLEEKNILHNKSKLIENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PU24</accession>
    <name>A0A182PU24_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PU24"/>
    <dbReference type="STRING" id="199890.A0A182PU24"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010460-RA">
        <property type="protein sequence ID" value="AEPI010460-PA"/>
        <property type="gene ID" value="AEPI010460"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010460"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022727">
        <property type="entry name" value="Cuticle_C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39068">
        <property type="entry name" value="LARVAL/PUPAL CUTICLE PROTEIN H1C-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39068:SF2">
        <property type="entry name" value="MIP24391P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11018">
        <property type="entry name" value="Cuticle_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010460-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="752" mass="78374" checksum="5171CCFF65428018" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUW8</accession>
    <name>A0A182PUW8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUW8"/>
    <dbReference type="STRING" id="199890.A0A182PUW8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010755-RA">
        <property type="protein sequence ID" value="AEPI010755-PA"/>
        <property type="gene ID" value="AEPI010755"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010755"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38337">
        <property type="entry name" value="AGAP010540-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38337:SF1">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010755-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="277" mass="31467" checksum="91814A3D101DD2D0" modified="2016-09-07" version="1">MVKLYPTWTNQTLDSTLVSNDSTVNLDQEHGHLGLLLASGEAIFIYLVPALLHLNGYILAVLIYRFADNEQLQSLIERVFILSSNPRRLVLTLWLYFGLGLFWLGVSIAYVTLLGIDGVTVFERFLSFGWTGGLARWTHTGEVLRTLLSVTLFFHDLVQMVVIVSYGLMCYMLRCYLKALKEKLLLHTIEPLNWMREICEFRKLLHHLNTKISLPVASLTVLNLSYTVSSVAHLFHNMTACPINIFTASLTNILLWLVIALMPFFQVSQHRVAAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV53</accession>
    <name>A0A182PV53_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A182PV53"/>
    <dbReference type="STRING" id="199890.A0A182PV53"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010840-RA">
        <property type="protein sequence ID" value="AEPI010840-PA"/>
        <property type="gene ID" value="AEPI010840"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010840"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000001">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000091">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000004">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="339"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010840-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="812" mass="92341" checksum="D2D0E5EE39AC9B62" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVN6</accession>
    <name>A0A182PVN6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="19">3.1.-.-</ecNumber>
            <ecNumber evidence="19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="19"/>
    <dbReference type="EC" id="3.6.4.12" evidence="19"/>
    <dbReference type="AlphaFoldDB" id="A0A182PVN6"/>
    <dbReference type="STRING" id="199890.A0A182PVN6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011023-RA">
        <property type="protein sequence ID" value="AEPI011023-PA"/>
        <property type="gene ID" value="AEPI011023"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011023"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
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        <property type="entry name" value="DNA2/NAM7-like"/>
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        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
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        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="20">
        <location>
            <begin position="93"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="21">
        <location>
            <begin position="599"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="21">
        <location>
            <begin position="703"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="22">
        <location>
            <begin position="780"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011023-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1074" mass="121698" checksum="8E698068950DEB17" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW65</accession>
    <name>A0A182PW65_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PW65"/>
    <dbReference type="STRING" id="199890.A0A182PW65"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011202-RA">
        <property type="protein sequence ID" value="AEPI011202-PA"/>
        <property type="gene ID" value="AEPI011202"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011202"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008132044" description="GDT1 family protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011202-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="51007" checksum="F6BD8090077FBE56" modified="2016-09-07" version="1">MYVCVFYLILVCMLDTAGIGADKMPQEDISVVTEVDGLSPDGSSSVPTEGKGLLSSDIGFVHAFAASFMVIIVSELGDKTFFIAAIMAMRHPRLTVFAGAIAALALMTVLSVLFGIAATIIPRVYTFYISTALFALFGIKMLYDGYHMSATEAAEELEEVQSDLRKREDELVRSMSGSRKETVELVPLSDTEEQRSKVSDILPRRHGSNHGSIHSLVEQKSPNTSSGVALRLSASASQLQAAGSGIGSKPGISAATLDSNNTNNAMMTASVEGGLATDAGSGGEQGGDGGGGSTANGESSRSKLLLLDGGGEQRQRLRTVATNGSSIQEPHPGSTALVANATVNGSASKMLEREVNSGGSLMSQDAESGTGSGRRGTGRGRNNNSALKMLLRIFIQAFTMTFMAEWGDRSQLTTVILSARENVYGVIAGGIIGHSICTGLAVIGGRMIAQRISVRTVTLIGGVVFLLFALSALIFGPGEEEPVKVPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW99</accession>
    <name>A0A182PW99_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PW99"/>
    <dbReference type="STRING" id="199890.A0A182PW99"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011236-RA">
        <property type="protein sequence ID" value="AEPI011236-PA"/>
        <property type="gene ID" value="AEPI011236"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011236"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF120">
        <property type="entry name" value="CELLULAR RETINALDEHYDE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="113"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011236-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="336" mass="38512" checksum="E7AB7B22F56D0ADC" modified="2016-09-07" version="1">MTTTRVILNFPWTSSEKLKGDFFQDTGVTDAVMKIARKELREDKAIREQSLEQLREWLQKNGDVEGVRTDDLFLLRFLRTKKFSVPMAQQMILKYLNFRKVFTHLIHTLDFMSPSVLKLLNGGYIFPSPIRDKHGRRVIVGFANHFNPAEHNSSDMARLHFITYETLMEDPENQICGLVHIGDFKGISTAHVACWNPTDFLRIMKWGEQSVPMRNKEVHLVNVPSTVKYIIEGAKSMVSKKMKERLQVHVTVNDLCRKVDPACLPKELGGTMPMAEMIELWKMELAAKRNLVLSSANMRILSDRGIISRNGTDRNNNSNSLGMETITGSFRKLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWE1</accession>
    <name>A0A182PWE1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWE1"/>
    <dbReference type="STRING" id="199890.A0A182PWE1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011278-RA">
        <property type="protein sequence ID" value="AEPI011278-PA"/>
        <property type="gene ID" value="AEPI011278"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011278"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000009">
        <property type="entry name" value="inositol polyphosphate 5-phosphatase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000060">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041611">
        <property type="entry name" value="SKICH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17751">
        <property type="entry name" value="SKICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011278-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="580" mass="67645" checksum="4D4CCED9D78A97F8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWI3</accession>
    <name>A0A182PWI3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWI3"/>
    <dbReference type="STRING" id="199890.A0A182PWI3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011320-RA">
        <property type="protein sequence ID" value="AEPI011320-PA"/>
        <property type="gene ID" value="AEPI011320"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011320"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000376">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000392">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF247">
        <property type="entry name" value="DPR-INTERACTING PROTEIN DELTA, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="107"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="204"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011320-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="419" mass="47280" checksum="5B28C7610A6691C4" modified="2016-09-07" version="1">MMDEPRFAQPIPNVTVAVGRDANLPCVVEHLGTYKVAWIHIDRQMILTIHRHVISRIPRYSVTYDNSNTWLLHVSQAQQDDRGYYMCQVNTNPMISQVGYLQVVVPPNILDIESTPSSVAVRENQNINMTCRADGFPTPKIIWRREDGQSITVERKKKVMVYDGEVLHLTKVSRNEMGAYLCIATNGVPPSVSKRIILDVEFSPMIWVPNQLVGAPLSTDVTIDCHTEAHPRAIIYWVYNSVMVLPSKKYIIDYNENSYRAHMKLTIKGLSMGDFGNYRCISKNSLGETEGSIRVYEIPLPSTPSKQITHVTEPRETIPAVVSRNETIKVASQPEVLFPMKNDEGYAQRSPNGIPFERKGSLAIGQSFSYTDMPPKEFGVSNDARSSFGVFSLLSLTTSVVQSTLIVLYRQHCETWLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWQ5</accession>
    <name>A0A182PWQ5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWQ5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011392-RA">
        <property type="protein sequence ID" value="AEPI011392-PA"/>
        <property type="gene ID" value="AEPI011392"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011392"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011392-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="65" mass="7328" checksum="2D79C44AFA57D817" modified="2016-09-07" version="1">DSPAAWFAAAEAEFEVSNVNQLLERCTISEEQRISQLLYHVEMGDRSPSDFYRYMGQLAGNSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWY3</accession>
    <name>A0A182PWY3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Runt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWY3"/>
    <dbReference type="STRING" id="199890.A0A182PWY3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011470-RA">
        <property type="protein sequence ID" value="AEPI011470-PA"/>
        <property type="gene ID" value="AEPI011470"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011470"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF50">
        <property type="entry name" value="RUNT RELATED A, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="6">
        <location>
            <begin position="70"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011470-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="162" mass="16819" checksum="17349E3D0B98EC55" modified="2016-09-07" version="1">MEVPVTVVTEVQVTLTGTNGNGGTGNVGGTSTNGNGSSASAGGESGPPSAASILNDTYSKMTSDILAERTLGDFLSEHPGELIRTGSPLFVCTVLPPHWRSNKTLPVAFKVVALGDVGDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FGI0</accession>
    <name>A0A9I3FGI0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A9I3FGI0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015476-RA">
        <property type="protein sequence ID" value="AEPI015476-PA"/>
        <property type="gene ID" value="AEPI015476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015476-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="55" mass="6456" checksum="E7A6397531495201" modified="2023-06-28" version="1">RLARPHCLQLLADRSPTGRRHRLPRKCLLQRDPQLAALQPERVRRDLPTKTLPHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FH39</accession>
    <name>A0A9I3FH39_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A9I3FH39"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015493-RA">
        <property type="protein sequence ID" value="AEPI015493-PA"/>
        <property type="gene ID" value="AEPI015493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051427">
        <property type="entry name" value="Nectin/Nectin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277:SF108">
        <property type="entry name" value="FASCICLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277">
        <property type="entry name" value="NECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039939473" description="Ig-like domain-containing protein" evidence="8">
        <location>
            <begin position="33"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="135"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015493-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="388" mass="43039" checksum="FB84EFE72DB153F2" modified="2023-06-28" version="1">MQSSTKMNNNYHHLRLLVALCSCYSLLAAVQSQQIETIPASPSFHTLYERNVELLCRADKPIDLCRVRLPGPSGETYDVSSLPSGVKRIGDDSRGECGVRLSTFTTERIGKFVCLLTIAGQQFEAAIELRQRVPPRPTELKISKTTNLVDGGIRANQLLKARCSSRLGLPVANLTWFLDNKPIDESMLKPAQITTEMQDGKSLQTIQQEVNLYVTAEHNGMALVCVANHPAFKIEQRTSIPLNVKFAPEEIPHIHIDELPASGSATVNITIHANPQPITRWTVNGRLIKEGESVDIYQAYIPRPTSANGEYRVLLKNNDCSKERATLFTLEATNPLGTQTYVIKAVPVDVDGAEVNRNDDYADDSNGSTFWLISVWTFFCSVIATRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZU9</accession>
    <name>A0A182NZU9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="3 10">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="3 10"/>
    <dbReference type="AlphaFoldDB" id="A0A182NZU9"/>
    <dbReference type="STRING" id="199890.A0A182NZU9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000180-RA">
        <property type="protein sequence ID" value="AEPI000180-PA"/>
        <property type="gene ID" value="AEPI000180"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000180"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000028">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="646"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000180-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="692" mass="79543" checksum="5B7DFA020F927149" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZW1</accession>
    <name>A0A182NZW1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calmodulin-lysine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.60</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.60" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182NZW1"/>
    <dbReference type="STRING" id="199890.A0A182NZW1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000192-RA">
        <property type="protein sequence ID" value="AEPI000192-PA"/>
        <property type="gene ID" value="AEPI000192"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000192"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018025">
        <property type="term" value="F:calmodulin-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000344">
        <property type="entry name" value="Blast:Calmodulin-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025800">
        <property type="entry name" value="CaM-Lys-N-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13539">
        <property type="entry name" value="CALMODULIN-LYSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13539:SF3">
        <property type="entry name" value="CALMODULIN-LYSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000192-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="494" mass="55420" checksum="B65CC3F6B6972743" modified="2016-09-07" version="1">MRSVGVSPMATTATTSVEERPRDEVEEPDREGAGGQDDATDDRWQRRRRRHEDDINWKMSTQQQVTPDRAMVVAADDPTGTVQAPAPGTAPTVDGENNPIKALRRQRRIEGAAGTDPTAAATVPSITVRPTMPIGGGADADRLRSSRLRPAGGMGVEDTGTDGGPLAVDIIEQNDDKNNRTGREDTANNNRDPDVARELEAALERKRHNTVNARRRWKLLAKALRHDSSEDDQFAKFNLIEADRAGDEKDENVYVYRLYDRYRLKLRLIGPERPWTASELIGFNNTGNICVWPSEEALAYYILSRLSQFDGTSVLELGGGMTCLAGLVLAKYGQPAFVHVTDGNELSVENVRKSLVLNKFSCTIKSSVLKWERPRQDRDNESLEADDRYHFILSADCLFFDESRSQLIDTIWQLLAEEGVALITAPRRGQTLGLFLSECVARGFHYELLQCYNEAIWARHLELKETEGYDENVHYPLLVKMYKYGQCGTVLHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZW3</accession>
    <name>A0A182NZW3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">T-cell activation inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZW3"/>
    <dbReference type="STRING" id="199890.A0A182NZW3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000194-RA">
        <property type="protein sequence ID" value="AEPI000194-PA"/>
        <property type="gene ID" value="AEPI000194"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000194"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028031">
        <property type="entry name" value="DUF4460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027989">
        <property type="entry name" value="DUF4461"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027986">
        <property type="entry name" value="TCAIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596:SF1">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14687">
        <property type="entry name" value="DUF4460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14688">
        <property type="entry name" value="DUF4461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4460" evidence="2">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4461" evidence="3">
        <location>
            <begin position="200"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000194-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="58663" checksum="105FCD8265943565" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZY2</accession>
    <name>A0A182NZY2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U2A'/phosphoprotein 32 family A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182NZY2"/>
    <dbReference type="STRING" id="199890.A0A182NZY2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000213-RA">
        <property type="protein sequence ID" value="AEPI000213-PA"/>
        <property type="gene ID" value="AEPI000213"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000213"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040091">
        <property type="entry name" value="LRRC56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22708">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22708:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000213-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="51979" checksum="96C3647DEEA01160" modified="2016-09-07" version="1">MPEEQIPLDEYHRPGSSSSSAPRSRQPSVGELGDNGPPDHGGGGGHFVAIRNMLNATRNRPVARIAPLEPSFVPAPQRYFPIVIPAEPTIEELLRQAAGTQDLATVSEIKLKVISHMTSLQRIPCFIPQLRSLILEGSIVMTLRDLGCDMTFLRYLNVSRCSLKHLDGTTGLESLEELVADYNLIEEVGPCTNLINIKKISLKGNRITDVGSVTFLALCEKLEVLDLRENFVAEHPSFWHVLRTNIPQLRCLNETQCREMVHDDTDLSSSDYRSSSSGSMEDVQRGRWDRPVAVSGREEGPPTSGSNSVQRRPITASTERRVTVELLDQQRPSTADPVKIKAQLTSGEPVVGSVITKARRRRRQRTAWGESTSCSSVSSSDSSFSKDFPDRLPQKLVDLELGVIGQGETSRGQPHRANTVSAPDTDDNDPQSLLRAARLWRQRSLQTRETIREQEQMLILRQLHDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P059</accession>
    <name>A0A182P059_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Salivary secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P059"/>
    <dbReference type="STRING" id="199890.A0A182P059"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000291-RA">
        <property type="protein sequence ID" value="AEPI000291-PA"/>
        <property type="gene ID" value="AEPI000291"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000291"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130759" description="Salivary secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000291-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="9965" checksum="0C5ED89778FC9A3B" modified="2016-09-07" version="1">MVFKVAALAVLLTIVAINAAPQLDQLPMTTPAVGEMPVGGNQTNPGDLQNNLNTTVPANPAEGVGGAENATMPSNIGGMPNQLGTRLANRINRPNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0H2</accession>
    <name>A0A182P0H2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium-coupled monocarboxylate transporter 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P0H2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000404-RA">
        <property type="protein sequence ID" value="AEPI000404-PA"/>
        <property type="gene ID" value="AEPI000404"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000404"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF41">
        <property type="entry name" value="GH19970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="116"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="948"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1203"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1312"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1384"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1415"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1461"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1490"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1521"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1571"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1610"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1670"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1710"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1740"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1772"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1841"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="695"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1343"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1343"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000404-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1934" mass="209188" checksum="2D64052BA00CD417" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0J6</accession>
    <name>A0A182P0J6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Aminopeptidase</fullName>
            <ecNumber evidence="20">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="18 20">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 20">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A182P0J6"/>
    <dbReference type="STRING" id="199890.A0A182P0J6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000428-RA">
        <property type="protein sequence ID" value="AEPI000428-PA"/>
        <property type="gene ID" value="AEPI000428"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000428"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000013">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF301">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
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        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 20" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 20" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 18 20" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130722" description="Aminopeptidase" evidence="21">
        <location>
            <begin position="29"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="24">
        <location>
            <begin position="47"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="22">
        <location>
            <begin position="272"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="23">
        <location>
            <begin position="579"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="19">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000428-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="915" mass="103856" checksum="2C48D72B05C3CCA8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0S7</accession>
    <name>A0A182P0S7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein quiver</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0S7"/>
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        <property type="protein sequence ID" value="AEPI000509-PA"/>
        <property type="gene ID" value="AEPI000509"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000509"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23591">
        <property type="entry name" value="TFP_LU_ECD_Crim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF28">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021350857" evidence="9">
        <location>
            <begin position="25"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000509-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="166" mass="18429" checksum="1D5B31B6D882977A" modified="2016-09-07" version="1">MVSIKACIILTALCLSLFISHSEAIWCYRCNSATPGCGDKFNWRGIGYLGDPCPEDDDICVKVIERKGTVETYTRDCLSSLQGFRTDIPADKYEGCRPAAKDLNLAHYVNTSIKELDVKRDHFDSTTFCFCFLDHRCNGASALGDATGYVWKLIGSLLLASIALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1K3</accession>
    <name>A0A182P1K3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1K3"/>
    <dbReference type="STRING" id="199890.A0A182P1K3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000785-RA">
        <property type="protein sequence ID" value="AEPI000785-PA"/>
        <property type="gene ID" value="AEPI000785"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000785"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000785-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="670" mass="84583" checksum="0500CC8316516D9D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1S6</accession>
    <name>A0A182P1S6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MOB kinase activator-like 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1S6"/>
    <dbReference type="STRING" id="199890.A0A182P1S6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000860-RA">
        <property type="protein sequence ID" value="AEPI000860-PA"/>
        <property type="gene ID" value="AEPI000860"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000860"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000860-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="48890" checksum="BF9C46008CA8534D" modified="2016-09-07" version="1">MKSVYERASPSKLGLIECILYLRKPMWQVGIVPAKLTDALGSLVRYAQESLNIFFCPTKARRKERDGDSNQGDTKLYLEEGLLERKLPDADLRLLVDLPAGLDYNEWLASHTLALFEHVNLVYGTISEFCTTSGCPDMTGPGTRMYLWFDEKGKKTRVAAPQYIDYVMTFTQKTVSDESIFPTKYANEFPSSFESIARKIVRLLFHVIAHLYAAHFREVALLGLHAHLNLTFAHLTAFHRRFNLIEAKETEVLRDLEIALRLTDDPTAPAAATATDGKADSSASIGSTTSASTGTTNTCSSSSTSSTASCSPPLLLTAAAAVPPHPNNGTILPPAPSSMPNSCSSAADNNNSSSSGESGAVHNHTLIDGDATAQPICKQPLESGSVVVNSNSHNHHQHHHHHHHPGKVESSCATGGSGSSTGSVGVSGCGVGYSVVGGGGGGSGHSGGGSSQQSSNTQTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1U6</accession>
    <name>A0A182P1U6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-2-macroglobulin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1U6"/>
    <dbReference type="STRING" id="199890.A0A182P1U6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000880-RA">
        <property type="protein sequence ID" value="AEPI000880-PA"/>
        <property type="gene ID" value="AEPI000880"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000880"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
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        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049135">
        <property type="entry name" value="TEP1_CUB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21412">
        <property type="entry name" value="TEP1_CUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="5">
        <location>
            <begin position="191"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000880-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="90489" checksum="AFD1B1EAC80D3B0D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1V5</accession>
    <name>A0A182P1V5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1V5"/>
    <dbReference type="STRING" id="199890.A0A182P1V5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000889-RA">
        <property type="protein sequence ID" value="AEPI000889-PA"/>
        <property type="gene ID" value="AEPI000889"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000889"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000889-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31210" checksum="BADC18D01251ED72" modified="2016-09-07" version="1">MLRWVQNFRWSSLLSDLKSKLTNDLPVPICTPTATERCDLSRTRHHPTTCPCRVRLAKEADSSDIVQFMQGNVLHSEPLLRSLQVSTIPSQAVLLDYIRLLLRDSFTLLALANGPPERIVGVAISRRSCPWDGKQLIERADRTRCDQLRKLLYIWSIVETEPNLHRHFCTRCLFEIALLATAIDSQRQGIGLHLTQRSLELARDLGFQFARMNCTCEYSSRVATKAGLECHWTVAYHHLVDSAKQPVVLPDPPHTHIKVHAMALFPGLSIKSSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P224</accession>
    <name>A0A182P224_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein TsetseEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P224"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000958-RA">
        <property type="protein sequence ID" value="AEPI000958-PA"/>
        <property type="gene ID" value="AEPI000958"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000958"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130715" description="Protein TsetseEP domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="743"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000958-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="989" mass="107839" checksum="E011CB22A5B40E99" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P287</accession>
    <name>A0A182P287_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Postsynaptic cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P287"/>
    <dbReference type="STRING" id="199890.A0A182P287"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001021-RA">
        <property type="protein sequence ID" value="AEPI001021-PA"/>
        <property type="gene ID" value="AEPI001021"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001021"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="31"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001021-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="148" mass="16897" checksum="8AED9703D46F396A" modified="2016-09-07" version="1">MSRAKTSITVAANQFFLLLDNNHIILSFLIAFFLQEWNDMNVRWNSSEYGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYPTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQVGRRRGAGEGGGLVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2Y9</accession>
    <name>A0A182P2Y9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2Y9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001276-RA">
        <property type="protein sequence ID" value="AEPI001276-PA"/>
        <property type="gene ID" value="AEPI001276"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001276"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130728" description="Secreted protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001276-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="10227" checksum="93DD7BE35E95976B" modified="2016-09-07" version="1">FTVFFAFVLAVATVAGQRFGFPHTSQFGLASLTGDFGGPTAFGGQDLSGTLNAGVRDPRQNRGPVVFPPAPADAPVESSGVIVGASGYGFVPPNTPQSKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3D1</accession>
    <name>A0A182P3D1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3D1"/>
    <dbReference type="STRING" id="199890.A0A182P3D1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001416-RA">
        <property type="protein sequence ID" value="AEPI001416-PA"/>
        <property type="gene ID" value="AEPI001416"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001416"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002706">
        <property type="entry name" value="AGAP009061-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000021">
        <property type="entry name" value="semaphorin-5B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000037">
        <property type="entry name" value="Unc-5 netrin receptor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057755">
        <property type="entry name" value="UNC5A-D-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25609">
        <property type="entry name" value="Unc5_NetrinR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="293"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="77"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001416-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="536" mass="56729" checksum="A10E309F744BD2F0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3T5</accession>
    <name>A0A182P3T5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3T5"/>
    <dbReference type="STRING" id="199890.A0A182P3T5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001571-RA">
        <property type="protein sequence ID" value="AEPI001571-PA"/>
        <property type="gene ID" value="AEPI001571"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001571"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="649"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="713"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="796"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001571-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="821" mass="92458" checksum="A7FA425625392E38" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P525</accession>
    <name>A0A182P525_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P525"/>
    <dbReference type="STRING" id="199890.A0A182P525"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002012-RA">
        <property type="protein sequence ID" value="AEPI002012-PA"/>
        <property type="gene ID" value="AEPI002012"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002012"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002012-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33646" checksum="0ABAEC1D2EEF0387" modified="2025-10-08" version="2">MYKQPGKIALITGGNRGIGLRIVKKLVECEIEVILGVRNPIDSRKAVEAYLEHAKIPAASCKLHYEQLDIGNMKSVREFATKIKAKFDKIHLLINNAGVMSVPFKLTDEGFESHMAINYYGHFLLTHLLLPQLRAAGSAECKARVVNVSSCVHKIGEIDYNDINKIKNYYPADAYNQSKLAQVLFAKYLNLIFEEEGMPILSNSLHPGVVNTDLFEHSSTNYIPWIRALLFKNPEEGSRTVVYAAIAPKLETRGGCYLSNCREASSHRHWNNSVQCEKLFNFTCDTLRIDDFFYKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P564</accession>
    <name>A0A182P564_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P564"/>
    <dbReference type="STRING" id="199890.A0A182P564"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002052-RA">
        <property type="protein sequence ID" value="AEPI002052-PA"/>
        <property type="gene ID" value="AEPI002052"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002052"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF224">
        <property type="entry name" value="RETINOL-BINDING PROTEIN PINTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="89"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002052-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="276" mass="31989" checksum="4D0461FC336A87CC" modified="2016-09-07" version="1">MRTTTPEEPVFVGNGVEETAELRTTSIATVTRWLLDERPDLVIPEGSRLILYFLRTTKYDIDKAKRKLMTFLNNRQKLTEWFKDRDPFRPEIQELLDIGVFLPLQQKDAQNRQVVIIRTAAHDPEKHKQDDVFKVDKMILDLLMYLDETVSINGVVAIFDMQGVTLGHALQLTPSMIKKSVESWENYPCKPKLLEFVNVPVHVNVVLNVFRSFMSQKMRERVIISRKSSSLDQSVTLPLELGGNGESYYELSEHWKQTVQDNASFFAKMEENVFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5J9</accession>
    <name>A0A182P5J9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative sodium-coupled neutral amino acid transporter 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 38 member 11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Putative sodium-dependent amino acid/proton antiporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P5J9"/>
    <dbReference type="STRING" id="199890.A0A182P5J9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002189-RA">
        <property type="protein sequence ID" value="AEPI002189-PA"/>
        <property type="gene ID" value="AEPI002189"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002189"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="12">
        <location>
            <begin position="41"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002189-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="430" mass="47480" checksum="77E80CFA62F163D2" modified="2016-09-07" version="1">MEIGLSDSIVHVFKLTGPLQQQDPNLHYLEHGIVRCGHLSGRFSYPGVMEAAYGKGGYYLLSLLQFMYPFLAMISYNVVVGDTLSKVLVRFVPSWGSSMGAVRFGVVLVVTIFVVLPLCLYKNVSRLAKASFLSLACVVLILMAVVYRLLSGDYSVVPNTPESWRFAHSDLIPAVGIMAFAFMCHHNTFLVYQSMQNATMERWEKVTHISVGFAWLVAALFGIAGYCTFRALSQGDLLENYCWDDDLMNFARVLFSISILLTFPIECFVSREIVRTQIKRFYSQEVVEYDTDKDPSHVTGEEDDRKSMITTLVIVFAAFIISPYTECLGPVLELNGLLAAIPLAYVLPGLAYIQLSPHSLLSQEKLPAAGLVLFGTIVTISGAAILMPNLIGDCRTGIIMGYCKDDELALNGTSFIAATTVDPNCAKDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5R8</accession>
    <name>A0A182P5R8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5R8"/>
    <dbReference type="STRING" id="199890.A0A182P5R8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002259-RA">
        <property type="protein sequence ID" value="AEPI002259-PA"/>
        <property type="gene ID" value="AEPI002259"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002259"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002259-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="130" mass="14130" checksum="15D78B080302AD14" modified="2016-09-07" version="1">MHPLLPRRRPGIPTCPINLATLRTRLPDLGSWSLPHICKEAVTSSGGTTTPEGTSGNYSSNITATADAFYQPTTVPGSLHTVVPGHGAAVTVQPTAQQHYHQTNLHKHYKAHKKMPAFRGRRGWCGCLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P617</accession>
    <name>A0A182P617_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase A2</fullName>
            <ecNumber evidence="3">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phosphatidylcholine 2-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P617"/>
    <dbReference type="STRING" id="199890.A0A182P617"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002358-RA">
        <property type="protein sequence ID" value="AEPI002358-PA"/>
        <property type="gene ID" value="AEPI002358"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002358"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04704">
        <property type="entry name" value="PLA2_bee_venom_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000002">
        <property type="entry name" value="Phospholipase A2 group III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Phospholipase A2-like central" evidence="13">
        <location>
            <begin position="85"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002358-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="288" mass="32269" checksum="00E96B704949BF90" modified="2016-09-07" version="1">MIHQMQVSCSSVLVADFRMTRMVELSSRPPYCKIHSDRGDIQRMLLASDTRKVRQVPRESVIALEEVCGEASDISGELQGGLGFIYPGTKWCGPGTIATNYSDVGRYAAEDQCCREHDLCPNVLLPGECRRGLCNRGAFTRSHCDCDARFRRCLQNLNTETANTLGAIFFNVVQVTCFGERRPCSVWQSHSGYDCPIQFYRSGTYSLPFGAAYGKHNSLRNSRSFDLGNANEVAGGNQLKVNSLGLISQNLFKDLVGFNQTEADELCSRWKYRPSEKYIPIMQQKSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P657</accession>
    <name>A0A182P657_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GST class-theta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P657"/>
    <dbReference type="STRING" id="199890.A0A182P657"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002405-RA">
        <property type="protein sequence ID" value="AEPI002405-PA"/>
        <property type="gene ID" value="AEPI002405"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002405"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000034">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="89"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002405-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="218" mass="24044" checksum="DA1779AB5C308EE3" modified="2016-09-07" version="1">MAPLILYHFPGSPPSRSALLALRNLDLDAEVKIVNLFAGEHLAEEFIAINPDHTVPTLVDEDYILWESKAIVTYLAEQYKPGCSLYPNDPKKRGLINHRLYFDSGTLFVALRDVLMAVLRSGATVIPPEKKENVHKALGKLESFLEGNDWIAGDECTLADLCVLANVATLKHVGVGLEAYANISGWYERCQELPGFDENDEGASFIGNAVKAKLEEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P662</accession>
    <name>A0A182P662_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Interacts with EMP65.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SLP1 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P662"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002410-RA">
        <property type="protein sequence ID" value="AEPI002410-PA"/>
        <property type="gene ID" value="AEPI002410"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002410"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000099">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="958"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="14">
        <location>
            <begin position="257"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="123"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="520"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="730"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1110"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1227"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1281"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="906"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="785"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1112"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1122"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1167"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1281"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1315"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002410-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1374" mass="149952" checksum="FD3D6C1D00D8520C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P708</accession>
    <name>A0A182P708_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P708"/>
    <dbReference type="STRING" id="199890.A0A182P708"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002708-RA">
        <property type="protein sequence ID" value="AEPI002708-PA"/>
        <property type="gene ID" value="AEPI002708"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002708"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037354">
        <property type="entry name" value="Commd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15857">
        <property type="entry name" value="COMM DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15857:SF0">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="99"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002708-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="196" mass="22857" checksum="88B21811143ED24E" modified="2016-09-07" version="1">MAKLIRPEQANHLRFLLDQSEEEKLSSTYETVRGALEGLIALLIDSTKLALTEREFHSAAQAALETINEKQTEILWQFITSKRNLVDNVMRAACQDELYYRDLEWRIEGRIASRTLRSQATPVIKMKFHLDTECVSEYREMLFSERADDLLETSTRRQVVAETDPVMLQHMIQVLEQALQEARTRRVRNYVKPTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P797</accession>
    <name>A0A182P797_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P797"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002799-RA">
        <property type="protein sequence ID" value="AEPI002799-PA"/>
        <property type="gene ID" value="AEPI002799"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002799"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130931" evidence="2">
        <location>
            <begin position="20"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002799-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="206" mass="22701" checksum="C434042008D2641B" modified="2016-09-07" version="1">MTKFICIALVLACVAAVHGQFRTNVQCTSFNDCVCKLPQIIGAVAGRTATANIRNPANGETYVLDLSRPSQAVTDYCNQVRQGLNPAVPCTSAHDYHHHHHHHHHHHHHTSSSTSSTTSSAVPSRSPSTASTTSSASSASAASSYKSVERQTKYLNEHLYIKSYLDIEEEDRNAKLLFQKVRPGGIRNYTPKILSENPKQDLDVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P7E5</accession>
    <name>A0A182P7E5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P7E5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002847-RA">
        <property type="protein sequence ID" value="AEPI002847-PA"/>
        <property type="gene ID" value="AEPI002847"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002847"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002847-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="174" mass="17018" checksum="B15F14572D3F9FFB" modified="2016-09-07" version="1">MLNSLEALAGKISPGSGKNSPSAPNGAATGGSELIDSNGNNKLLAGYHLRTKLPYQKPGLSNNNNNCNVVNNTPAATGIVPGVGGSGGLPVGLLSPQAVAMLGVSSIATSNTNGNNGSSSNIGTTSLGNLSVSTGVAAVSAANAAANSHRLTNGTSDAMIVDDVQMMGVSSKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9I3</accession>
    <name>A0A182P9I3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="5">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182P9I3"/>
    <dbReference type="STRING" id="199890.A0A182P9I3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003588-RA">
        <property type="protein sequence ID" value="AEPI003588-PA"/>
        <property type="gene ID" value="AEPI003588"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003588"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23596">
        <property type="entry name" value="TFP_LU_ECD_Tkv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000018">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000021">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000055">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF106">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="21">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="195"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003588-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="501" mass="55852" checksum="54A6005230796C58" modified="2016-09-07" version="1">MLRPTRVLTCYCEGHCPGNVQNGTCETRPGGSCFVSVEAVLDEETKQFVPEYSHGCMSPEQGGGLLQCKVGTVSPQLHGKSIVCCDNEDLCNQDLQPPYSPRTTTTPEPPLVNPNSMPLFALVISVVLCLAGLLVLIGAIYCIYRRREKRKPAYLMNSLYNTANGHMPIADLVEQTSGSGSGLPLLVQRTIAKQIQMVHSVGKGRYGEVWLAKWRDEKVAVKIFFTTEEASWFRETEIYQTVLMRNENILGFIAADIKGTGSWTQMLLITDYHELGSLHDYLQKRVLNPHMLKTLALSLSSGVAHLHTEIFGTPGKPSIAHRDIKSKNILVKRNGQCAIADFGLAVKYTSESDEIQIAPNSRVGTRRYMAPEVLSETLDLKVFEGFKMADMYSVGLVFWEMARRCITTVRGAKNTTTCEDYALPYQDVVPSDPSFEDMYAVVCVKGVRPPIPQRWQDEDILVVLSKIMQECWHPSPAVRLTALRVKKTLVKLETDCTIKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9W8</accession>
    <name>A0A182P9W8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9W8"/>
    <dbReference type="STRING" id="199890.A0A182P9W8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003722-RA">
        <property type="protein sequence ID" value="AEPI003722-PA"/>
        <property type="gene ID" value="AEPI003722"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003722"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="94"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003722-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="527" mass="56626" checksum="EF495D53E08B92BD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAB4</accession>
    <name>A0A182PAB4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAB4"/>
    <dbReference type="STRING" id="199890.A0A182PAB4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003868-RA">
        <property type="protein sequence ID" value="AEPI003868-PA"/>
        <property type="gene ID" value="AEPI003868"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003868"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003868-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="169" mass="18010" checksum="195A4FBB5849B294" modified="2016-09-07" version="1">MNSQEKPGGGESAGTDTAGIYTVTVPRLEVPFPGASPVNGCPPPGLVFPGSLLHGASKPPTVDFGTVNIYQQQQQQEKHGSTPAGKGGRNVTSTGGAKGHDPSFDDKSDNSSNLSVTANDEDSDIISEYIGHYGRWQFGWTFLLCLFQIPTTFHIFCLVFQVSDCSRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAE1</accession>
    <name>A0A182PAE1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in development during embryogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAE1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003895-RA">
        <property type="protein sequence ID" value="AEPI003895-PA"/>
        <property type="gene ID" value="AEPI003895"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003895"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000082">
        <property type="entry name" value="forkhead box protein B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF377">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN FD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="10">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="8">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003895-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="395" mass="43781" checksum="81A271EB7329F398" modified="2016-09-07" version="1">MPRPSRDSYGDQKPPYSYISLTAMAIWSSPEKMLSLNDIYQFITDRFPYYRTNTQRWQNSLRHNLSFNDCFIKVPRRPDRPGKGAYWTLHPKAFDMFQNGSLLRRRKRFKLHQTDKECLNEEFIALANMNRFFMAQSGAPTYHHEHPAAGYYPPLSEPLGSSISPGMVYAPISPPLSPPEDIAGAGATQHGTESPLTVPSVPTASATTTTVSNPKPKRSFTIESLIEPDSSSSDSEESTDRAQPPYQLHHHHQQQQLEHLRHLSQQQLMSNLTAFNEYAAAVQHHHQQQQHQAAVAAAAAATALGSSYAGSVPLHPLLLPLGKMQSPASYFLHSAATAPYHHHHPHHLHHLYPGHLPASSAAVAASTGPSAHHLHPHELGPHQGLRPEPPSLAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAE2</accession>
    <name>A0A182PAE2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAE2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003896-RA">
        <property type="protein sequence ID" value="AEPI003896-PA"/>
        <property type="gene ID" value="AEPI003896"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003896"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003896-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="177" mass="19971" checksum="C68F1F393674D950" modified="2016-09-07" version="1">MVGSNGTLMTMRLVRSKLRKREESSTVSPVTASNVEAAPHHHHHHNHHHHQHHHPHSHHQLHHNGTSHPQQNNSSSNHHHQQQNGGSSPETGYSVPTPIAFRQSPSTVWVFPPLPPQPNIYNASSQDALVHNEKTGFKGLKRQLSGRFKRLVSRKAHEPAPVIPPELKPQLKTIYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAE6</accession>
    <name>A0A182PAE6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ferritin</fullName>
            <ecNumber evidence="15">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomer of 12 light (L) chains and 12 heavy (H) chains; L and H chains are disulfide-linked. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble ferric iron core is deposited.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A182PAE6"/>
    <dbReference type="STRING" id="199890.A0A182PAE6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003900-RA">
        <property type="protein sequence ID" value="AEPI003900-PA"/>
        <property type="gene ID" value="AEPI003900"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003900"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.10:FF:000017">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF43">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="4 15" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131048" description="Ferritin" evidence="16">
        <location>
            <begin position="27"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="17">
        <location>
            <begin position="41"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003900-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="216" mass="24606" checksum="C692322E92511F0A" modified="2016-09-07" version="1">MMKSIFFGIVALMFAAVVMQQDQASAQVTDTDAPSSTDEWNYMNRSCSAKLQDQINKEFDAALFYLQYGAYFAQYHVNLPGFEKFFFSAASEEREHGMKLIEYALMRGQKPIDRNTFSLNFANPAARVEPVQGSVALTALKAALAKEQEVTKSIRELIKVCEEDHNDYHLVDYLTGEFLEEQHQGQRDLAGKITMLSKLLRTNPKLGEFMFDKQNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAS1</accession>
    <name>A0A182PAS1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAS1"/>
    <dbReference type="STRING" id="199890.A0A182PAS1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004026-RA">
        <property type="protein sequence ID" value="AEPI004026-PA"/>
        <property type="gene ID" value="AEPI004026"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004026"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF1">
        <property type="entry name" value="LD38433P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="67"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004026-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="520" mass="57976" checksum="A6EE71748B0C8DD0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAU5</accession>
    <name>A0A182PAU5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A182PAU5"/>
    <dbReference type="STRING" id="199890.A0A182PAU5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004050-RA">
        <property type="protein sequence ID" value="AEPI004050-PA"/>
        <property type="gene ID" value="AEPI004050"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004050"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="84"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="398"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004050-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="548" mass="62268" checksum="BBB9F4C776EEFA00" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB88</accession>
    <name>A0A182PB88_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PB88"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004193-RA">
        <property type="protein sequence ID" value="AEPI004193-PA"/>
        <property type="gene ID" value="AEPI004193"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004193"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF106">
        <property type="entry name" value="FI01104P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004193-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="523" mass="58412" checksum="C239D26276A6CAA2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PB93</accession>
    <name>A0A182PB93_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PB93"/>
    <dbReference type="STRING" id="199890.A0A182PB93"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004198-RA">
        <property type="protein sequence ID" value="AEPI004198-PA"/>
        <property type="gene ID" value="AEPI004198"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004198"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004198-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="239" mass="26829" checksum="27AFC2831630823A" modified="2016-09-07" version="1">MADYPPQDATFSGSSHTRGIRSSKKSTTILLGVLLAVGTARADISTLLRGGYSNNNILQDDGYHYDKPKVPFEEPTTPRKCAVTDQNPDGSCGYDYPKPDQSFTLPNEYLPPTTTDDNDHSSYDNHYAKNDNNHSPNYNDHSPDYTRAGISPTEHYSTDDYNDQTYDYDYASNNDDHASNDYYTPNDYTARRNHNQVSANPDGSCGYDYPKPDQSFTLPNRVSTTMTTTRRPTTVNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PC60</accession>
    <name>A0A182PC60_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GMP phosphodiesterase delta subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PC60"/>
    <dbReference type="STRING" id="199890.A0A182PC60"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004515-RA">
        <property type="protein sequence ID" value="AEPI004515-PA"/>
        <property type="gene ID" value="AEPI004515"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004515"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="entry name" value="GMP phosphodiesterase, delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051519">
        <property type="entry name" value="PDE6D_unc-119_myristoyl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951:SF1">
        <property type="entry name" value="PROTEIN UNC-119 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951">
        <property type="entry name" value="RETINAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GMP phosphodiesterase delta subunit" evidence="6">
        <location>
            <begin position="62"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004515-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="263" mass="28694" checksum="0E8B7953F2B2FF1E" modified="2016-09-07" version="1">MSVVGKKLSSSISAQGGDAEGPAATGEPGGSSSNTTVPSPITPDYVLQLNKITDDYLCTPDANIYEIDFTRFKIRDLESGAVLFEIAKPSLTDITHTSAAVTASGESKVKEAGTANDDASGVPSSKAPTNKPTGGAEDTAEETFEPNAGRYVRYQFTPQFLKLKTVGATVEFTVGSKSVKNFRMIERHFFKDRLLKTFDFEFGYCIPFSKNTCEHIYEFPAIPPDLVNEMIQHPFETRSDSFYFVDGCLVMHNKADYAYNGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCA3</accession>
    <name>A0A182PCA3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCA3"/>
    <dbReference type="STRING" id="199890.A0A182PCA3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004558-RA">
        <property type="protein sequence ID" value="AEPI004558-PA"/>
        <property type="gene ID" value="AEPI004558"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004558"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13761">
        <property type="entry name" value="TGF_beta_BMP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.970:FF:000042">
        <property type="entry name" value="AGAP011934-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000003">
        <property type="entry name" value="Bone morphogenetic protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF310">
        <property type="entry name" value="PROTEIN 60A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0339">Growth factor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131118" description="TGF-beta family profile domain-containing protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="12">
        <location>
            <begin position="314"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004558-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="437" mass="49824" checksum="32A275E0441AB848" modified="2016-09-07" version="1">MMLKISACAVVIVLVVHVGLVRSSGFYIDNGIDQTVREKSVELHERQEIEHEILELLGLPDRPNKQHVHPSLRKSAPQFLLNIYHKFTEEMNGGKRRKRYADGSNLFTIADERAIGESDVIMSFLNKANRHLPKIRHHRGGHRLWFDTTEIDTERDNNQLLYASLRMYKNRTTERPWDAIVRGRQLVVRASLIGGYDAAKDGHRLELVAEQSVPYNYEGWVELNATQAMQRWIVERVANKGIFVEVYYAESPRKEILPHDVGLILSNRFGRYQPFLVGYCKGPELVKPTAAIAGGSGGRSKRSTRRKQGGSGKRTDRARNPFLERFGSGSERQKSCQIQTLYVSFRDLNWQDWIIAPDGFGAFFCFGECNFPLNTHMNATNHALIQTLVHLMHPTRVPKPCCAPTKLNPISVLYHIDDANINLKKYKNMVVKSCGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCA5</accession>
    <name>A0A182PCA5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCA5"/>
    <dbReference type="STRING" id="199890.A0A182PCA5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004560-RA">
        <property type="protein sequence ID" value="AEPI004560-PA"/>
        <property type="gene ID" value="AEPI004560"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004560"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13333">
        <property type="entry name" value="M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13333:SF5">
        <property type="entry name" value="M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004560-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32450" checksum="C8957D84295EADC1" modified="2016-09-07" version="1">MFVVQSGAVKLGQFSRSFSSFSRIAISPSGKTVLSNNLPLCGTVSPRTVGVWRASTGSAFGGLPIVNNSHNIVQMRWNSTDEQQSSRQRIRKRPMLMDFPHLVWPSVIKTVRNWIMVHFIIRPYFDREFSLPDFIQGAKQALQVVSSSLAGGEVKHLDGLVDRAALTDLKQSIAKMSVAERYDLQVEKEDIYFSFPYQVGVMFDESDDDSQKRFVEITMVFHVLRGLKGMIERGETVPLNVGVLPEFRDKISICNYRFIKEFTKGVDSDWTVNVVNHFKPSDYVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCM0</accession>
    <name>A0A182PCM0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ASD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shroom family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCM0"/>
    <dbReference type="STRING" id="199890.A0A182PCM0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004675-RA">
        <property type="protein sequence ID" value="AEPI004675-PA"/>
        <property type="gene ID" value="AEPI004675"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004675"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014799">
        <property type="entry name" value="ASD2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027685">
        <property type="entry name" value="Shroom_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012">
        <property type="entry name" value="APICAL PROTEIN/SHROOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012:SF32">
        <property type="entry name" value="PROTEIN SHROOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08687">
        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51307">
        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASD2" evidence="7">
        <location>
            <begin position="481"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004675-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="764" mass="81215" checksum="1FBA5B147CE68847" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCP3</accession>
    <name>A0A182PCP3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PCP3"/>
    <dbReference type="STRING" id="199890.A0A182PCP3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004698-RA">
        <property type="protein sequence ID" value="AEPI004698-PA"/>
        <property type="gene ID" value="AEPI004698"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004698"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004698-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="445" mass="51288" checksum="D590A6AC2924114F" modified="2016-09-07" version="1">MEKEPCTEFKMESLESFEPLVNPIRQYRNRSKRTLKTGEEKLAEVLAKIASLQKSTEKTDGIDRTKVRTYNVKLRLRKSLLYKCFDCGSCFANPDFLELHEKSHAEQGKCDIDLRQEPGECAGEMNLKQNAWFVGDFGDEDEDDGDGEHHILQLDCTVEEGEDIFDITFDRTKCEKTYTMKYKVKKEPVGKCGHCSKPFYSVECLQQHELEHEKFLDIANIEPSINIIRSPRIEESTMTLDESFYDALEVSDILEHSSGMIDCSGEGRLASGAGIMLEYRIIPRRSVSGEKELVQVKDQTVGKLGCEEKERKDARMVNQSECQLLTVKQERDVIVKEEPVEEEQPPPPSGRMIKQEIKEEPMEEESTSHIERPEQQQQHNQHLNLQAKFACTSCSKRFRMRAALLVHERTHTGIKAYRCKHCTKSFISRGKLFMHSFAQHRKRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD25</accession>
    <name>A0A182PD25_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 10"/>
    <dbReference type="AlphaFoldDB" id="A0A182PD25"/>
    <dbReference type="STRING" id="199890.A0A182PD25"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004830-RA">
        <property type="protein sequence ID" value="AEPI004830-PA"/>
        <property type="gene ID" value="AEPI004830"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004830"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052273">
        <property type="entry name" value="PPIase_FKBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP7/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222:SF3">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004830-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="168" mass="18914" checksum="D3F2609DC3DB3C30" modified="2016-09-07" version="1">MSQNLINFRTFSLRYSFDRDQPFTFQLGAGQVIKGWDQGLTDMCVGEKRVLTIPPELGYGDRGAGNVIPGGATLVFDVELINIGDSPPTTNVFKEIDENKDMQLSREEVSEYLKKQMVAADGGQESEDIKNMIAEHDKLVEEIFQHEDKDKNGYISHDEFSGPKHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE06</accession>
    <name>A0A182PE06_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PE06"/>
    <dbReference type="STRING" id="199890.A0A182PE06"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005161-RA">
        <property type="protein sequence ID" value="AEPI005161-PA"/>
        <property type="gene ID" value="AEPI005161"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005161"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF2">
        <property type="entry name" value="AGAP013096-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005161-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="715" mass="74862" checksum="2F96E06C35FE1B82" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PE31</accession>
    <name>A0A182PE31_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PE31"/>
    <dbReference type="STRING" id="199890.A0A182PE31"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005186-RA">
        <property type="protein sequence ID" value="AEPI005186-PA"/>
        <property type="gene ID" value="AEPI005186"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005186"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF2">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="16">
        <location>
            <begin position="397"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005186-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="626" mass="70251" checksum="46AC6E1B8B534BF8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEG5</accession>
    <name>A0A182PEG5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">ATP-binding cassette sub-family B member 6</fullName>
            <ecNumber evidence="30">7.6.2.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">ABC-type heme transporter ABCB6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="45 46">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="46" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="46">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="45" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="45">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>coproporphyrin I(in) + ATP + H2O = coproporphyrin I(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66768"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167478"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:66769"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>coproporphyrin III(in) + ATP + H2O = coproporphyrin III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:66665"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>coproporphyrinogen III(in) + ATP + H2O = coproporphyrinogen III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:66681"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>heme b(in) + ATP + H2O = heme b(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:19262"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61360"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58687"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:61361"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>protoporphyrin IX(in) + ATP + H2O = protoporphyrin IX(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61336"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:61337"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>uroporphyrin I(in) + ATP + H2O = uroporphyrin I(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167480"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:66773"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>uroporphyrin III(in) + ATP + H2O = uroporphyrin III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66776"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167479"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:66777"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
            <location evidence="2">Multivesicular body membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Melanosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="29">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.5" evidence="30"/>
    <dbReference type="AlphaFoldDB" id="A0A182PEG5"/>
    <dbReference type="STRING" id="199890.A0A182PEG5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005320-RA">
        <property type="protein sequence ID" value="AEPI005320-PA"/>
        <property type="gene ID" value="AEPI005320"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005320"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015439">
        <property type="term" value="F:ABC-type heme transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18581">
        <property type="entry name" value="ABC_6TM_ABCB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000022">
        <property type="entry name" value="ATP-binding cassette sub-family B member 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032410">
        <property type="entry name" value="ABCB6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16185">
        <property type="entry name" value="MTABC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="26" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0967">Endosome</keyword>
    <keyword evidence="23" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="27" id="KW-0458">Lysosome</keyword>
    <keyword evidence="25 42" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="46" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0964">Secreted</keyword>
    <keyword evidence="21" id="KW-1278">Translocase</keyword>
    <keyword evidence="15 42" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22 42" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="44">
        <location>
            <begin position="246"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="43">
        <location>
            <begin position="570"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="41">
        <location>
            <begin position="815"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00024320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00024385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00024439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00031413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00047649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00047753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00047789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00048636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00049398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="43">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="44">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005320-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="848" mass="96741" checksum="14F2CBCDD63E2A23" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEP7</accession>
    <name>A0A182PEP7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Lysine-specific histone demethylase</fullName>
            <ecNumber evidence="16">1.14.99.66</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:60244"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.99.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.66" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A182PEP7"/>
    <dbReference type="STRING" id="199890.A0A182PEP7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005402-RA">
        <property type="protein sequence ID" value="AEPI005402-PA"/>
        <property type="gene ID" value="AEPI005402"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005402"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140682">
        <property type="term" value="F:FAD-dependent H3K4me/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000029">
        <property type="entry name" value="Lysine-specific histone demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.660.10:FF:000001">
        <property type="entry name" value="Lysine-specific histone demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000064">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000002">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017366">
        <property type="entry name" value="Hist_Lys-spec_deMease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038051">
        <property type="entry name" value="Histone_Lys-demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 16 17" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0678">Repressor</keyword>
    <keyword evidence="14 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="12 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="19">
        <location>
            <begin position="137"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="771"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="789"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="295"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="846"/>
            <end position="847"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR038051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR038051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005402-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="882" mass="97706" checksum="C352040F63117069" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFC7</accession>
    <name>A0A182PFC7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PFC7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005633-RA">
        <property type="protein sequence ID" value="AEPI005633-PA"/>
        <property type="gene ID" value="AEPI005633"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005633"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005633-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="185" mass="21839" checksum="8170BC487CFB4F92" modified="2016-09-07" version="1">MLSRSGLLSSDTDYRYSSNDCNNFTRCCLCGIFSPFIFYVDSQAAINCIKIALPPYHNFFCVNCLPQPTNTTEDGPISLYWEGSLFNNNDFLSLFDGYEYYHPDDRPTYYRNYDLIITEYCELPPNYMRIVCEPMPASVRMRKLYEIFPAVHQIPLNNYSSIWEMFSKVEQKYGEILKYYLTHMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFI1</accession>
    <name>A0A182PFI1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Eukaryotic initiation factor 4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182PFI1"/>
    <dbReference type="STRING" id="199890.A0A182PFI1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005688-RA">
        <property type="protein sequence ID" value="AEPI005688-PA"/>
        <property type="gene ID" value="AEPI005688"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005688"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045495">
        <property type="term" value="C:pole plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="118"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="316"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005688-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="436" mass="49614" checksum="0F22D0C37D05CC65" modified="2016-09-07" version="1">MATCISPHRAFPPLARLKAARRQLLAANLTIWRPFAWFIKIQFSTCIKVPNFNRENMDDNRQEQSHDGPAGMNPDGVIESNWNESYDNFDQMGLREELLRGIYAYGFEKPSAIQQRAIVPCVRGRDVIAQAQSGTGKTATFSIAILQQIKTEIPDCQALILAPTRELASQIQKVVISLGDFLKAQCHACIGGTNVRDDMRRLEQGCHIVVGTPGRVHDMISRNVLQVKNIKMFVLDEADEMLSRGFKDQIQDVFQKLPPDVQVILLSATMPADVLEVSEYFMRQPVKILVKKEELTLEGIRQFYVDVKFEEWKIGTLCDLYDTLSITQAVIFCNTRRKVDQLTEQMTEKTFTVSAMHGDMEQRDRDLIMKQFRTGSSRVLITTDLLARGIDVQQVSLVINYDLPTLRENYIHRIGRGGRFGRKGVAINFVTEQDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFS8</accession>
    <name>A0A182PFS8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PFS8"/>
    <dbReference type="STRING" id="199890.A0A182PFS8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005785-RA">
        <property type="protein sequence ID" value="AEPI005785-PA"/>
        <property type="gene ID" value="AEPI005785"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005785"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005785-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="320" mass="33787" checksum="ACD59F578A09E5D1" modified="2016-09-07" version="1">MDETAMLFALVIVMLVGSYLAGNIPLIMSLSEEKLKNVSIFGAGLLVGTALTVIIPEGIRSLYDERSLEQAAKGPGTSSGLPMDDHKHEHSNDEHSATIGLSLVLGFVFMMLVDQVSSRRTEGSSERNLTATIGLVVHAAADGVALGAAATTSHSDVEIIVFLAIMLHKAPAAFGLVSFLLHEGVERDRIRKHLLIFALAAPALTLLTYFGIGSEQKETLESLNATGIAMLFSAGTFLYVATVHVLPELTHRSDHGHGHGHGHHHGNYSLLEQQPPSSSAAVSGKPSPSSGGPGGLKNYELALLILGALAPLFLTLGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGP6</accession>
    <name>A0A182PGP6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PGP6"/>
    <dbReference type="STRING" id="199890.A0A182PGP6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006105-RA">
        <property type="protein sequence ID" value="AEPI006105-PA"/>
        <property type="gene ID" value="AEPI006105"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006105"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13195">
        <property type="entry name" value="FERM_C_MYLIP_IDOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041790">
        <property type="entry name" value="MYLIP_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FERM" evidence="12">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="474"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006105-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="569" mass="62312" checksum="1C676AE49E6C75AB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PGS3</accession>
    <name>A0A182PGS3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PGS3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006132-RA">
        <property type="protein sequence ID" value="AEPI006132-PA"/>
        <property type="gene ID" value="AEPI006132"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006132"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006132-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="82" mass="8999" checksum="0A576CF446574F75" modified="2016-09-07" version="1">MRRMTASVSGADLCRSIDYEPVKVPPLATASLTASLSIPSECIVLSVADEPSPERKVQKLEPAPCYIRKDGRAVHPKPFRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PH90</accession>
    <name>A0A182PH90_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bee-milk protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PH90"/>
    <dbReference type="STRING" id="199890.A0A182PH90"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006299-RA">
        <property type="protein sequence ID" value="AEPI006299-PA"/>
        <property type="gene ID" value="AEPI006299"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006299"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000045">
        <property type="entry name" value="Blast:Protein yellow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF13">
        <property type="entry name" value="DOPAMINECHROME TAUTOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131255" description="Bee-milk protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006299-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57428" checksum="07AE2BAE1953C3F7" modified="2016-09-07" version="1">MTSGRRTWMVLAGVLLVLAVITGPAGSYSPFKKGPQHGSFTRTSPANGERGTVREREREREREQERLATPYVGPLVGLEAAGGKRAANDFLEDVGKNVFDTVYHWKMIDFMYPSLQLRNNAIRTREFIPENNLPLGVDRFRDRLFITTPRWNPGVPATLSYLPLPAQDRSQPLMPYPDWSYHTSPRNPDCSKMMSVYRIQVDECDRLWVLDAGVTDTLTNLQQVCPPKIMAFDLQNDELLFTYVLPEEQVKEDSLHTNIVVDVRDGQCEDAFAYVADVWRNGITVFDMRKFKSWRTTNHLYNPNPLASDYNYQDLNFQWSDGVFGMSLAPVHRSGDRMLLFHPMSSFMEFQVPASILRNETVWEGFGLAAKAFQPVGTRGRMGQSSTAGIGKNNVQFFTLVQQSGVGCWDLGKPYNRNNLGVVEKNAQKLTFPNDLKVDHEPQQSLWVMSNKLPVFLYDKLDYTQTNFRVLMADARKAIENTVCDPRVPPSLAFDAAQLECELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHN7</accession>
    <name>A0A182PHN7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PHN7"/>
    <dbReference type="STRING" id="199890.A0A182PHN7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006447-RA">
        <property type="protein sequence ID" value="AEPI006447-PA"/>
        <property type="gene ID" value="AEPI006447"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006447"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016355">
        <property type="entry name" value="NR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086:SF15">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FTZ-F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="315"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006447-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="390" mass="37765" checksum="A80F3C70518B73A4" modified="2016-09-07" version="1">MLLDMDQQHSTVFMSLNMSQYSMLSESGSPPPGGGGAGGNTQLLSLAAAASAANSTGQNTGMPPPQYTGGGGGGGGGATAGGYPGATGLLLGSSNNNNNNNSTSNNNLPSHHNNNNNGNAGGNGQHHHHHHTSHHGQHMGGGGGAGGGAGGGGNGQSHSQSNGTGGYGSLYGGFHESAAAPPSAYSMFSHVPTGGGGGGGGGGIGGTGGSGPYHHGGSDGGIGGNSNSSSGGGGGGGPAAAGGQTVAGAGGTSSAAAAAAAAYLAIPASGTSGGSCSSGGGASGGSLIEHQTALNSLSVVSAIQCDQTDLKYFIEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERQCHIDKTQRKRCPYCRFQKCLEVGMKLEGEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHS8</accession>
    <name>A0A182PHS8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHS8"/>
    <dbReference type="STRING" id="199890.A0A182PHS8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006488-RA">
        <property type="protein sequence ID" value="AEPI006488-PA"/>
        <property type="gene ID" value="AEPI006488"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006488"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048512">
        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000005">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000042">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006488-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="267" mass="30020" checksum="7F3EB7280F533BA7" modified="2019-01-16" version="2">MAKNNSSSFDEIEQTALLATQLAQLCTNADYADVTFIVENNRIPAHRVILATRSEYFRALLYGGLKESKQSEIRLDVPVKAFEHLIKYIYTGSMSLKQMSDSEIIETLGLAHQYGFIDLQKAIVGRLSKVISIENVCLLFNIAQLFHLDHLLSASGAFMDENATRIVSLESFRGLSYDALLTLLDRDTFDAPEVDIFKAVHGWCCFNQADQPKCKALYGKVRFTLIPQKDLFAVVRSANVLDSDRLLDIIDEKAKIKNPTYRGLVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PID7</accession>
    <name>A0A182PID7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PID7"/>
    <dbReference type="STRING" id="199890.A0A182PID7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006699-RA">
        <property type="protein sequence ID" value="AEPI006699-PA"/>
        <property type="gene ID" value="AEPI006699"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006699"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF42">
        <property type="entry name" value="FI18455P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006699-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="103" mass="12017" checksum="3B70B89BF3560000" modified="2016-09-07" version="1">MQIFGYEPNVDYPAYDKIPSGLTFRCADRQPGYYADIETRCQVWHWCLPTGYMFSFLCPNGTVFNQAYRVCDWWTNVNCPESEAMYSINDDLYRDVEGNLIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJG6</accession>
    <name>A0A182PJG6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein N-terminal asparagine amidohydrolase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJG6"/>
    <dbReference type="STRING" id="199890.A0A182PJG6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007080-RA">
        <property type="protein sequence ID" value="AEPI007080-PA"/>
        <property type="gene ID" value="AEPI007080"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007080"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026750">
        <property type="entry name" value="NTAN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498">
        <property type="entry name" value="N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14736">
        <property type="entry name" value="N_Asn_amidohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007080-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34480" checksum="8496A2AD84F79E14" modified="2016-09-07" version="1">MVLVLNGVIQDERPINTHALFLEHPVYRETATQLLSIPTKTVGAPGLLYVCQREMAAVAPHDRNVNIIGSDDATTCIIVVVRHSGSGAIALAHLDGSGTDEAVSAMVARVQELAFGYPEGRIELQLIGGFSDPQGYAEDLFSNIMQSFHKHPLEIDLTQSCVGELNTMVRDDINWPIIYGVGVNIKTGEIFPANFPDKGPDLPLRMARHFTGSHQVLDIYDAAVGMLRIGPFNYDPLRGVDLWLAQSDEFILKHLSTSPDVEPPHFAMQVRATLRYIQDNQFPAVTVFRNNNPHYFRRDETTGCWTPVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJX8</accession>
    <name>A0A182PJX8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJX8"/>
    <dbReference type="STRING" id="199890.A0A182PJX8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007244-RA">
        <property type="protein sequence ID" value="AEPI007244-PA"/>
        <property type="gene ID" value="AEPI007244"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007244"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000351">
        <property type="entry name" value="Cadherin 74A, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000098">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000168">
        <property type="entry name" value="Cadherin-related family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000118">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="78"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="200"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="320"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="438"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="540"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="663"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007244-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="712" mass="77859" checksum="E5D4769120B7DAE3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKJ4</accession>
    <name>A0A182PKJ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKJ4"/>
    <dbReference type="STRING" id="199890.A0A182PKJ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007461-RA">
        <property type="protein sequence ID" value="AEPI007461-PA"/>
        <property type="gene ID" value="AEPI007461"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007461"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040055">
        <property type="entry name" value="Ribosomal_uS10m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13334">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13334:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US10M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="8">
        <location>
            <begin position="53"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007461-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="165" mass="19443" checksum="435886C56D9782CA" modified="2016-09-07" version="1">MLKWFNLMRTIAPLAPRPIHTVRWYSEVVPVASQSVQQPATVGVPDKLYSRVELQMKGIDPEVMKSYAMYAKTAAEHLDIEVGKHWTLRKALKDRLTLLKSVHIYKKHRVQYEVRNYYRFMHFHKLTGSTLDTFLEYIERNLPEGIALKVTKVELQELPEHLRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKU3</accession>
    <name>A0A182PKU3_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PKU3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007560-RA">
        <property type="protein sequence ID" value="AEPI007560-PA"/>
        <property type="gene ID" value="AEPI007560"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007560"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007560-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="417" mass="46416" checksum="74CF37B1640608FC" modified="2016-09-07" version="1">MEPVRSNENNAGAAQVDPYQLREEEINAIATVIPTAVLPEDDNFGSQDADGARDFLQLCTGEELPPMSLRQSKTREMLISQFPTLPPVVPPIVDNFQELNLEAINTPLFKRPLGASTPCVQVAVPELQLPMPMADLQEFVPVEVVPENRTEESIPLVVPVSAESNAEPTGRPVVESSSSEEAVPVPVQRTRRPRREVALTQRLEPFESTPRATARPRRNFDIFSFPYRTVWNKTIQDVQSLLQEMYQQQQLRTHLQELSEVPVMREATTNQKVDSGFGQTTNERSRNLQLPMSTTETSNLADNRTDDKVIVALDEQLRDILNQQHAIVTSDLAMSVQPNHLESVDGKLAEASDGYQLPMVIGDTPVNIEADVMNKPSQTETAVSVLQETEKIASTSAVPVPDQQEQPTKRISRKRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLC1</accession>
    <name>A0A182PLC1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLC1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007739-RA">
        <property type="protein sequence ID" value="AEPI007739-PA"/>
        <property type="gene ID" value="AEPI007739"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007739"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007739-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="53" mass="6385" checksum="674E38E5D57437BA" modified="2016-09-07" version="1">MVLTFPSREKRTQPAPRHRRHHRATGIRCSGRRRRRCELGRDRSRCPGHPRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLC9</accession>
    <name>A0A182PLC9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PLC9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007747-RA">
        <property type="protein sequence ID" value="AEPI007747-PA"/>
        <property type="gene ID" value="AEPI007747"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007747"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112:SF0">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007747-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="126" mass="14451" checksum="C2A76AE1B681FBC9" modified="2016-09-07" version="1">MTVLNGSFIVHQWLNDSIEVVFRMQSRLGNQQFNHYPMKLPSSGCCSFFDNLQVNYGRQTESIHNLPAIGECPISPRVVDMINFAFPQEVVSRVMPQGLWKALMTARLNGEVIVTYYFLVKGHHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLH5</accession>
    <name>A0A182PLH5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PLH5"/>
    <dbReference type="STRING" id="199890.A0A182PLH5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007795-RA">
        <property type="protein sequence ID" value="AEPI007795-PA"/>
        <property type="gene ID" value="AEPI007795"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007795"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007795-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="285" mass="31952" checksum="AFBAA921FC19C084" modified="2016-09-07" version="1">MFYIIGLGLGDPEDITVKGLNIIRECDRVYLESYTSVLCCGQEKLEAFYGKKLILADREMVEQRADEILESAESVSVAFLVVGDPFGATTHTDLMLRAKEKGIKTSIIHNASIMNAVGCCGLQLYHFGETVSIPYWDENWKPDSFYDKIVANLKHGLHTLCLLDIKVKEPTLESLMKKKREYMPPRFMSVSEAADQLLQIVAKKSQKEPAADGQRGEHKLYENTLVVGLARVGHETQQILACSLSEMKSVDLGPPLHSLIIPNGQLHPLEVEFLQQFGELNQQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PLW8</accession>
    <name>A0A182PLW8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="EnsemblMetazoa" id="AEPI007940-RA">
        <property type="protein sequence ID" value="AEPI007940-PA"/>
        <property type="gene ID" value="AEPI007940"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007940"/>
    <dbReference type="Proteomes" id="UP000075885">
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        <property type="entry name" value="Znf_MYND"/>
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        <property type="entry name" value="APICAL JUNCTION COMPONENT 1 HOMOLOG"/>
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            <begin position="1130"/>
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        <location>
            <begin position="1160"/>
            <end position="1272"/>
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            <end position="202"/>
        </location>
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            <end position="274"/>
        </location>
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            <end position="329"/>
        </location>
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        </location>
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        </location>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01753"/>
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        <source>
            <dbReference type="Pfam" id="PF26649"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007940-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1437" mass="158733" checksum="DAC74A811F99616C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PM86</accession>
    <name>A0A182PM86_9DIPT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AEPI008059"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008059-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="42" mass="4979" checksum="7A60DC91EAC84ADD" modified="2016-09-07" version="1">MPEMPGVWSLELRMPGQTEVSPSFIPYTGAKEEFKQNWHKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMN2</accession>
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        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Anopheles epiroticus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
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        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
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        <property type="gene ID" value="AEPI008206"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040973">
        <property type="entry name" value="CLIP_SPH_Scar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18399">
        <property type="entry name" value="CLIP_SPH_Scar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131534" description="Peptidase S1 domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="421"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008206-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="694" mass="75664" checksum="EDBAFA3E9662BFAE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN85</accession>
    <name>A0A182PN85_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Obscurin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Myofibril</location>
            <location evidence="11">Sarcomere</location>
            <location evidence="11">M line</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
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        <property type="gene ID" value="AEPI008410"/>
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        <property type="term" value="C:M band"/>
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        <property type="term" value="C:neuronal cell body"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:axon guidance receptor activity"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1079"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1098"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1131"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1164"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1190"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1318"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1369"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1400"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2666"/>
            <end position="2675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008410-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4569" mass="511005" checksum="13425471BE179C0A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNH4</accession>
    <name>A0A182PNH4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PNH4"/>
    <dbReference type="STRING" id="199890.A0A182PNH4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008501-RA">
        <property type="protein sequence ID" value="AEPI008501-PA"/>
        <property type="gene ID" value="AEPI008501"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008501"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008501-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="116" mass="13113" checksum="79F78FDECAB37D40" modified="2016-09-07" version="1">MTPLTVRYLTRRFIGEYSSNTDLLYKQTVTLDSGVLDVEIVDISAENDNGFPVEQIQWADACLIVYSITDRGSYEYAQRSLAELRQLQNAPSAYLVGNKADLDHLRELALLLRNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPA4</accession>
    <name>A0A182PPA4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPA4"/>
    <dbReference type="STRING" id="199890.A0A182PPA4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008783-RA">
        <property type="protein sequence ID" value="AEPI008783-PA"/>
        <property type="gene ID" value="AEPI008783"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008783"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20681">
        <property type="entry name" value="T-box_Drosocross-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000010">
        <property type="entry name" value="T-box transcription factor TBX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002070">
        <property type="entry name" value="TF_Brachyury"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF204">
        <property type="entry name" value="SPADETAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00938">
        <property type="entry name" value="BRACHYURY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="9">
        <location>
            <begin position="60"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="404"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008783-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="456" mass="50422" checksum="6F5816765659A54C" modified="2016-09-07" version="1">MTADLMDLRMHHHLALQTEFYRMQMQRLPDPYPAMLPVPPPRPLMIPPRYNTLPDVDIKLQNRDLWSQFHKIGTEMIITKSGRRMFPSMRLSVNGLEAEENYFILLEMVPISDCRFKFSGSQWVPAGGAEPQSPQRIYFHPDGPALGSHWTSQPIVFNKVKLTNNTLDSNGHIVLTSMHKYQPRIHVIKASDATQIPWAPQQAFTFPETEFVAVTAYQNDRITKLKIDNNPFAKGFRETGQSRCKRKAGLLMSPDSGLGNRSSEEEDESDGQETGPEAKRPRTSSLAGSLSSLDDSELSVSDGSSSGTSSPVVVDDFGSPVRPSASTAGAFYQNHHPAMHAGLFASHHPHQLPHPMLHQAAGAGGSWMDLMFPSFTRPQTAGSPHGLEPSALVQAAQQLQQFARREFLPLPVPSPRTPNSSTSSSSSSEEDSPIRKPQLPQHSLPFSISAILGHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPD2</accession>
    <name>A0A182PPD2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPD2"/>
    <dbReference type="STRING" id="199890.A0A182PPD2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008811-RA">
        <property type="protein sequence ID" value="AEPI008811-PA"/>
        <property type="gene ID" value="AEPI008811"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008811"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000131">
        <property type="entry name" value="cyclin-dependent kinase 14 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF246">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008811-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="302" mass="34784" checksum="1C61474E631894FB" modified="2016-09-07" version="1">MDLTNQVVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHDIVHTRETLTFVFEFVNTDLSQYMERHPGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISEMGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDIWGVGCIFVEMITGMPTFPGIRDTYDQLDKIFKILGTPTEDTWPGVTHLPGYKLQMLGFFKPRKLGLSFPRLYDINEGETMATSFLQLNPDNRISADEALRHRYFASLPKKLYELPDELSIFTVEGIYLHPEPNRHHGHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPD9</accession>
    <name>A0A182PPD9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PPD9"/>
    <dbReference type="STRING" id="199890.A0A182PPD9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008818-RA">
        <property type="protein sequence ID" value="AEPI008818-PA"/>
        <property type="gene ID" value="AEPI008818"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008818"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000061">
        <property type="entry name" value="Ets DNA-binding protein pokkuri"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="2">
        <location>
            <begin position="60"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008818-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="149" mass="16470" checksum="FBF1639E3E01861D" modified="2016-09-07" version="1">MQVESAAKWRVPPLDLSAVSVLTNESERRWNHANSNSNSNSNNNGTSNGGSTGPGRDSSTQTSIKKIQYGADGLPIDPRDWTRANVWTWLINLAQSEGLDISPELAQKFPMNGKALCLMSLDMYLSRVPIGGKMLYRDFRVRLARAMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQE1</accession>
    <name>A0A182PQE1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">superoxide dismutase</fullName>
            <ecNumber evidence="1">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182PQE1"/>
    <dbReference type="STRING" id="199890.A0A182PQE1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009171-RA">
        <property type="protein sequence ID" value="AEPI009171-PA"/>
        <property type="gene ID" value="AEPI009171"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009171"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000010">
        <property type="entry name" value="Copper-zinc superoxide dismutase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131681" description="superoxide dismutase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="8">
        <location>
            <begin position="92"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009171-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="225" mass="23948" checksum="B0A1AEE2ACE1B1F3" modified="2016-09-07" version="1">MLRWSAALRGISFLLVALRGLSAVTGQTAIVGRLTDDVEFIDPTVGLGPGGTASGIPLGPGGFRGFEILPRPEPSWKVGATLVADNPEQQIMGTISFRQWAPGHVQTAINVTGLPVGKHAVHVHAFGDMREGCKSTGPHFRSSIIGNIDVKEDGNAMIDFHSPYINLFGFAGIVGRSIVIHEKPSEIYRFPDLSINNPISFQGEEDTVGARIACGLITILDNVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQF4</accession>
    <name>A0A182PQF4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Nori-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">TP53-regulating kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">p53-related protein kinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PQF4"/>
    <dbReference type="STRING" id="199890.A0A182PQF4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009185-RA">
        <property type="protein sequence ID" value="AEPI009185-PA"/>
        <property type="gene ID" value="AEPI009185"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009185"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000323">
        <property type="entry name" value="TP53-regulating kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="9"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009185-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="243" mass="27619" checksum="C489B6FFB375134B" modified="2016-09-07" version="1">MAVAMEKQDTAQQLLKQGAEGKLYVSTYKGNRCLVKERFEKKYRHPALDRQLTRQRIKAEQKAFQRCAAAGLSTPALYGVDLEQRKIYMEYLEKSKTAKEFVDELARTSAPDALADSPSLKKLAEQIGHMVGVLHRNNLVHGDLTTSNMLLDPLEKATEEDAIFPYRLVTIDFGLSHFSDNHENKGVDLYVLERAILSAHSQHPGLFGMILEAYREHNTNHCKETIAKYEEVRARGRKRTMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQH0</accession>
    <name>A0A182PQH0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PQH0"/>
    <dbReference type="STRING" id="199890.A0A182PQH0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009201-RA">
        <property type="protein sequence ID" value="AEPI009201-PA"/>
        <property type="gene ID" value="AEPI009201"/>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd11793">
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR047271">
        <property type="entry name" value="Ephexin-like"/>
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        <property type="entry name" value="EPHEXIN, ISOFORM D"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="617"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="980"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="536"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="1069"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
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            <end position="260"/>
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        <location>
            <begin position="406"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
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            <end position="1101"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009201-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1101" mass="120378" checksum="EF17C1FAEB1F514E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQT1</accession>
    <name>A0A182PQT1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQT1"/>
    <dbReference type="STRING" id="199890.A0A182PQT1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009312-RA">
        <property type="protein sequence ID" value="AEPI009312-PA"/>
        <property type="gene ID" value="AEPI009312"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI009312"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="10"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009312-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="247" mass="27210" checksum="50417BF2CF3B98D9" modified="2016-09-07" version="1">CGAANQEIRIVGGRPTGVNQYPWLARLVYDGQFHCGASLLTKDYVLTAAHCVRRLKRNKIRVILGDYDQFVASETPAIMRAVTAIIRHRSFDQNSYNHDIALLKLRKPVEFTKTIRPVCLPKERSEPAGQLGTVVGWGRTSEGGTLPALVQHVDVPILTLDQCRSMKYRASRITSNMLCAGKGKQDSCQGDSGGPLLVRNGDKHEIVGIVSWGVGCGRAGYPGVYTRVARYLPWLRANLDDTCLCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR07</accession>
    <name>A0A182PR07_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PR07"/>
    <dbReference type="STRING" id="199890.A0A182PR07"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009388-RA">
        <property type="protein sequence ID" value="AEPI009388-PA"/>
        <property type="gene ID" value="AEPI009388"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009388"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000101">
        <property type="entry name" value="Similar, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF17">
        <property type="entry name" value="PROTEIN SIMILAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="126"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="282"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009388-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="326" mass="37145" checksum="1A0F94E48A03ABC5" modified="2016-09-07" version="1">MRIICVSNTIFFTLSRFRNNEKRKEKSRDAARCRRSRETEIFQDLGSLLPMRAEEVEHLDKASVMRLSIAFLKARKMLELFPDFESKEQITIKEDNDISMDSMEEFQYNEAKLSLKSLGLDPETIALQTLDGFLMILSADGDVTYISENVSEYLGISQIDIMGQPIWDYSHQCDHDELREALNGRHHSPSELLNGVANSDCRPMENRDFFLRLKCTLTSRGRSVNIKSASYKVLHVTGHIACKDKEGQRQLVAIARPLPHPANIEVPLGSSTFLTQHTLSMKFSYVDDIMLSLLGYQPLDLLGKSLYDCHHGTDAEHLMATFKHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PR20</accession>
    <name>A0A182PR20_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PR20"/>
    <dbReference type="STRING" id="199890.A0A182PR20"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009401-RA">
        <property type="protein sequence ID" value="AEPI009401-PA"/>
        <property type="gene ID" value="AEPI009401"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009401"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022727">
        <property type="entry name" value="Cuticle_C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39068:SF4">
        <property type="entry name" value="AGAP000382-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39068">
        <property type="entry name" value="LARVAL/PUPAL CUTICLE PROTEIN H1C-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11018">
        <property type="entry name" value="Cuticle_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009401-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="223" mass="22946" checksum="C97C94B72BF53925" modified="2016-09-07" version="1">MVRFWSAKIGAPYKRRRPYGLTASVHQLSSSSASLQSTPINPTALKMAFKFVILAALVAAVSAGGPAAYSIAAPSVDYHSVGASHEHTVKGLYGQNVLSQYSKAVDSAHSSVRVHSSRLSNDGYAYAPAVKYAAPAYAAHYAAPAVHYPAAAAYAAPAVHYPAAAHYAAPAVHYAAHAPIVKAAYPAAYAAPLAYKAPLAAPVAAVHGGSVVQFAGLGASYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PRD5</accession>
    <name>A0A182PRD5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PRD5"/>
    <dbReference type="STRING" id="199890.A0A182PRD5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009519-RA">
        <property type="protein sequence ID" value="AEPI009519-PA"/>
        <property type="gene ID" value="AEPI009519"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009519"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
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</entry>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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            <strain evidence="9">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="8">Epiroticus2</strain>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
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                <person name="Haas B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
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            <dbReference type="Proteomes" id="UP000075885"/>
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            <dbReference type="Google" id="ProtNLM"/>
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</entry>
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            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
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                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:neuron projection development"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Fry_C"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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            <end position="132"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010337-PA"/>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="671" mass="72374" checksum="A2D4DE07565C00CF" modified="2016-09-07" version="1"> </sequence>
</entry>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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                <person name="Howell P."/>
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                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Larimer J."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <end position="64"/>
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    </feature>
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            <dbReference type="EnsemblMetazoa" id="AEPI010352-PA"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <taxon>Diptera</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Howell P."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Poon T.W."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUB2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010548-RA">
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        <property type="gene ID" value="AEPI010548"/>
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    <dbReference type="VEuPathDB" id="VectorBase:AEPI010548"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
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        <property type="entry name" value="Insect_Hormone_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39940">
        <property type="entry name" value="PROTHORACICOTROPIC HORMONE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39940:SF1">
        <property type="entry name" value="PROTHORACICOTROPIC HORMONE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131865" description="Spaetzle domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010548-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27592" checksum="1626B9477F6D0F5D" modified="2016-09-07" version="1">MKLTLVVCGFLLGLILSPIDGRLKYAEVVPDNAFQKLSDSNLSLDVPESPLRETTSSQGKGAEPPDPPTDVGVLPLNCFPLADRLHKYDWARFFLRHLAVASRTDGFQNEASVSKEDSSNGQVDSSSMAGLVTRKRSDFNREISADLYAQYPSSCACQTKYELLDLGYTHFPRYIVNAICQNRSSSSRKCWRGSSCKEIPYKVRVLTKRTDGESSEQDHHSTLLPEPLRDYWRFKTVTIAAACQCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUF9</accession>
    <name>A0A182PUF9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUF9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010595-RA">
        <property type="protein sequence ID" value="AEPI010595-PA"/>
        <property type="gene ID" value="AEPI010595"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010595"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046987">
        <property type="entry name" value="Myo9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184:SF5">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010595-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="78" mass="8758" checksum="423797F90899EA10" modified="2016-09-07" version="1">VYVGALSLHYEALSVEASKQTTAEEIVSCIVERLGLTGNNYELAEVAGECKERRLSAHEKPVSVMLLWPMHSEKDFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVE1</accession>
    <name>A0A182PVE1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PVE1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010928-RA">
        <property type="protein sequence ID" value="AEPI010928-PA"/>
        <property type="gene ID" value="AEPI010928"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010928"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF1">
        <property type="entry name" value="DAMPENED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="459"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010928-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55493" checksum="ED082B8AC042E62B" modified="2016-09-07" version="1">MVMSDQHVQQHQGINLMDLPTELLGHIFSYILDEVYSVLNYIRTSPSLDRPFKVTDELFDLSTMAMEYFKEYIEPNLPDIAYFTNSTKSFAALETSSSILSRDTSHSNSSSPPQSNMVLRKGIRKIKQGMKRYNNQLTVLRSELRTCKRKATEQAKTITEQQKLLAEQQKQTLEFANRLDDTDKKNDELSRKFSTVLQELNKCKTELQYWRSKSPATTNCNPYGQVVPSCELQNMGSQSMMSDDIDLISVGINRSTALTITEENRKKDEPGQNKEKVEYISQLVKAECDAVEPSESVELLPAIVTKAGLKRKLECLTAVTEIFNNEIPCSNEPVRLEELACLNPPSASASLAASYSSSSLPSAVNALVTPSNDGNIILSSTTSNTLKDNSGICTSENVYSTGLHGSSVEELEQMNEDKRCPSTKHDVGSCGTILPFASTKPFFTNAKAIHQSNTNHILNQQNNSDSKNNSSSFSSNVDSKNDSTSNDSTTNNHIKKIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PW41</accession>
    <name>A0A182PW41_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PW41"/>
    <dbReference type="STRING" id="199890.A0A182PW41"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011178-RA">
        <property type="protein sequence ID" value="AEPI011178-PA"/>
        <property type="gene ID" value="AEPI011178"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011178"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF14">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="363"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011178-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="508" mass="59916" checksum="42F6C560A69C6935" modified="2016-09-07" version="1">HHPSSALHFRSHYRYRRELARQVRSDFWYIIHPFSRFRFYWDIWLIVYFYTIALLFPFLFSFTSLVRVRGRAYLISLILNIVGTLDFVIHACTGYLEDRSNSEVVLHHGKILLRYLKSDMLIDLLAMSPLTLLVGVFYDDSNHSLPLTVIMDSIHGAMMLKIISLRHVSGYLENVFERYKIDLLNYYIVRIVLTSVLIVHWCVCLYKLTIYEWDMAVTGAALSYMEAFYQYGLCLYSVSWFMFAYSFIDREIPSDARGKAFSTACIVIGYMFKLFIFLQIINLVEIMSSMDRKYAEVTNQLQTYVRTKQLHTADMKQRLLYYYAKRYEHCFFQEDIIMESLSDTLKKRITDYSAINFLRKVKIFDGIPNDVLLPLVERMTKEIYLQEDLIIKAGSFGDKMYFIIVGMVAVYTHSRKEICHLSDGDNFGEVSMFTQKKRLVSVVAVEFTQVYVIERTAFRSLFPADHVVHQRLQEMANKRMHITLVFEEQHKNYLLKMGMSQKEIKIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWA2</accession>
    <name>A0A182PWA2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWA2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011239-RA">
        <property type="protein sequence ID" value="AEPI011239-PA"/>
        <property type="gene ID" value="AEPI011239"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011239"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011239-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="82" mass="9194" checksum="AF7EBFBEE348DFF1" modified="2016-09-07" version="1">MAGGGFDVTFITFTIKGGFVQTVADRNPSFRFLAEPCRFDDDEAYLIEQCLVKVGLEHFVCILTFVHFPDHAYAVRLGSCQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWE5</accession>
    <name>A0A182PWE5_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PWE5"/>
    <dbReference type="STRING" id="199890.A0A182PWE5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011282-RA">
        <property type="protein sequence ID" value="AEPI011282-PA"/>
        <property type="gene ID" value="AEPI011282"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011282"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF27">
        <property type="entry name" value="ADHERENS JUNCTION PROTEIN P120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="416"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="460"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="745"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="655"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="891"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="892"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="937"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011282-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="965" mass="103535" checksum="305C601C272E10F9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWI1</accession>
    <name>A0A182PWI1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWI1"/>
    <dbReference type="STRING" id="199890.A0A182PWI1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011318-RA">
        <property type="protein sequence ID" value="AEPI011318-PA"/>
        <property type="gene ID" value="AEPI011318"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011318"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011318-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="182" mass="20935" checksum="7B74C6DB00B78B76" modified="2016-09-07" version="1">RIRLPEIHLPAFDGSFETWLSFSDAFKSLIDSNKGALVKDAQKIIADIDCTATNYSVAWELHEGRYQNKKLVVKRYLDALTGIAAVKRESYESLTNLIDGFERNINATKKLGLNIELHCTSFRSNWKFHIIREITWNLPHGQVNNSKFIIPSELNLADPRFYESSPIDLLIGRESCIRRDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWL3</accession>
    <name>A0A182PWL3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWL3"/>
    <dbReference type="STRING" id="199890.A0A182PWL3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011350-RA">
        <property type="protein sequence ID" value="AEPI011350-PA"/>
        <property type="gene ID" value="AEPI011350"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011350"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF9">
        <property type="entry name" value="RE58324P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="125"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011350-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="296" mass="33917" checksum="35E92585924E6773" modified="2016-09-07" version="1">MEMVPEGNNFVIVKECELPAMMEELEKYFPHSLKPENRMNESVGIFCPPDKLERMDLIKDENVLFEWHSPLYMNFTHVGIMFRMEEIYREKVNGKLEGHIYGDIYVHECPAELDLALEPLAANEVIMKPLCITDVKDIHDLYPAGDIESLELFEKLVRQLPGFGVFNQSDNELAAWSLQSYYGGMFSMQTKPKFRRKGYGIQLAQSLTKLVIQRGYTPFVVIRPENDASRGLYMKLGFRKAFESVRGTFVPYAGENHLQIDLPTEIQSEILKEETCTIEPADVTNGIATDNEKGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWL8</accession>
    <name>A0A182PWL8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWL8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011355-RA">
        <property type="protein sequence ID" value="AEPI011355-PA"/>
        <property type="gene ID" value="AEPI011355"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011355"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011355-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="156" mass="17651" checksum="B2D0B3D1DD4769B5" modified="2016-09-07" version="1">MKSLTIPMWKEIREEFDRLSNQVYYEPRKRVAARPAPNNATSRSERTLLTATAHSNALNSATAVDPVPHSKNVARTSLKARYKTAAIKENSRIYIHPSKIFSLNTLATQFSPRPRMQCLDVARAQIMRGSSTPHFTKIQMRLLRGVNANTLVAYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWM4</accession>
    <name>A0A182PWM4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWM4"/>
    <dbReference type="STRING" id="199890.A0A182PWM4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011361-RA">
        <property type="protein sequence ID" value="AEPI011361-PA"/>
        <property type="gene ID" value="AEPI011361"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011361"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011361-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="206" mass="23185" checksum="910C935136EDBDE7" modified="2016-09-07" version="1">SDATAPRDKTESDTELDDADDVSSHPTFSDEFSFKDSLCVWSLEANLSHRATNLLLKLIRKNNHLELPQDARTFLQTPSSACTQRMVATVSNGKMWYQGSANSIKSYYKNLSPNVMTLRLYFFVDGLPLHKSVMAQFWPILMRIFDEPEASIMTVALFYGEAKSSSVQDYPEPFVSVMNALQQFGISINGRAFQIRLRTIIADSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PY12</accession>
    <name>A0A182PY12_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PY12"/>
    <dbReference type="EnsemblMetazoa" id="AEPI014229-RA">
        <property type="protein sequence ID" value="AEPI014229-PA"/>
        <property type="gene ID" value="AEPI014229"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI014229"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI014229-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="443" mass="47767" checksum="0F0845C55254EA43" modified="2016-09-07" version="1">MFMFLQLASGSPFFGVSVQGGFQAEADIAAAARTVRLVVESSQQSMVTFAARLPLSTAVQNVTAGAVLQLYTIAITNIVTLTDRISWAAINRTDPPAEVFATLHTAYNTVVASLQQESPAAVTLITSYSSANGATIAKSGQNVLLILGDIFNSLSIFSNTINSFPSQVTAKDVFEKLTKSQIATIVGALDALRAELTIISGTLMETAMTLTDSDALLSNYINMLSQSFSNIDSNLSNLFNKLTSLSVDFERQFRASESTVANDVRVFNARITSFRDNIIAPSASQILSITRPFSEKFSEAYTIIKPNVEDTFQLLINTATDTVLNAAQNLLFTTYRVLDSAMQRIPNAPSQGKACASEFINPYVQYLSSNIASVLTGCISSTASQAEGVLRNQLQGISALLKDRQAYFKMWNDAINGVSNTSDADTRNIALAKLTAIQSMRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PYW0</accession>
    <name>A0A182PYW0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PYW0"/>
    <dbReference type="STRING" id="199890.A0A182PYW0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015028-RA">
        <property type="protein sequence ID" value="AEPI015028-PA"/>
        <property type="gene ID" value="AEPI015028"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015028"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF103">
        <property type="entry name" value="CYTOCHROME P450 6BS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015028-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="498" mass="57746" checksum="BE8C3F7602C4714F" modified="2016-09-07" version="1">MWFLSVEALVALLALLGGAVYFVVRKQSYWKERGIPHPKPTFFFGSFKDAGTKIHFTEELEKFYSIYKGKHPFMGVYLITTPVALPTDLELIKSIFVKDFQYFHDRGTYYNEKHDPLTAHLFNLEGQKWRNLRNKLTPTFTSGKMKMMFPTVVAAGQQLRDFMEENVHRQSELELKDIMARFTTDVIGTCAFGIECNSMRDPDAEFRAMGKLFMDRQPSQFVNMMVQFSPKLSRLLGIRLIDKEVSAFFLKVVRDTIDYRVNNGIQRNDFMDLMIRMLKNTENPEEALSFKEVAAQAFVFFFAGFETSSTLLTWTLYELALNPEVQEKGRQCVKEVLAKHNGEMTYEAIHDMKYLDQILKESLRKYPPVPMHFRMTAQDYRVPGTDSIIEAGTMLLIPIFAIQRDPDIFLEPEKFDPERFSAEEEEKRHPFAWTPFGEGPRVCIGLRFGMMQARIGLAYLLQGFSFAPYEKTSIPMKFVTNSFILGPREGLWLKVDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ36</accession>
    <name>A0A182PZ36_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PZ36"/>
    <dbReference type="STRING" id="199890.A0A182PZ36"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015104-RA">
        <property type="protein sequence ID" value="AEPI015104-PA"/>
        <property type="gene ID" value="AEPI015104"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015104"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="149"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015104-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="340" mass="39257" checksum="9E5DBE4E2585510A" modified="2016-09-07" version="1">MDSYLGLAQSKVKPRSLVDGLTNRTATIKKRPPRPTGYPTTSRPISTSSIVIDSAAQFRYLQEEHRSLLERHKKLEDSYTALQNEYAKVKSDNERLQGAYEELQESYNSVTAKNFNAGKFLVYLKLKRRTDKETLEKRNIIKNEACFNTYLQDVVMLDHPRIPRVIHECITVLEANDRFMRSPGLYRVSGDHNTIQNLRYDINANNYKRLRKLKGPHEVCGILKLFLRELKDPLISLDTCSKYLPDVIQMKTNTRFRIKQLISSLDDVRQNTLKVLMKHLRTVAAITENEVDSFSLGLLFSSLIFNETLADVCPVKFQKLTAVPRECIIAMMEDYDAIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ40</accession>
    <name>A0A182PZ40_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GST class-theta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182PZ40"/>
    <dbReference type="STRING" id="199890.A0A182PZ40"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015108-RA">
        <property type="protein sequence ID" value="AEPI015108-PA"/>
        <property type="gene ID" value="AEPI015108"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015108"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000034">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF3">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE E11, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="89"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015108-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="221" mass="24812" checksum="BC7CD54C82674FB1" modified="2016-09-07" version="1">MPKLVLYTLHLSPPCRAVELTAKALGLELEQKNINLLAGDHLKPEFLKLNPQHTIPVLDDDGTIITESHAIMIYLVTKYGKDDTLYPKDPVKQARVNAALHFESGVLFARMRFIFERILFFGKSDIPEDRVEYVQKSYQLLEDTLVDDFVAAPTMTIADFSCISTISSIMGVVPLEKAAYPRIHGWIDRLKQLPYYEEANGGGGTDLGKYVLAKKEENAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PZ96</accession>
    <name>A0A182PZ96_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PZ96"/>
    <dbReference type="STRING" id="199890.A0A182PZ96"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015161-RA">
        <property type="protein sequence ID" value="AEPI015161-PA"/>
        <property type="gene ID" value="AEPI015161"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015161"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF84">
        <property type="entry name" value="CYTOCHROME P450 28A5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015161-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="481" mass="54919" checksum="40703E7B1BDAC16E" modified="2016-09-07" version="1">MLLLLFGIVVGFVALVYLFLSWEFGFWEKYGVKGPKPKLLLGNIPYLLTKKRHIVYNYDQIYNDYKNEPAIGYYSIRTPQLMVRDPELIKEVLSKSFHNFSANDFSDTVDEKSDPLLARNPFSLSGEKWKTRRAEITPAFTNNRIKAMAHLMDEVCVHMTGYLREQAKSSNGVTTLDAKEVMAKYTTDVVASCIFAIDAQSFVKENPEIRQMGKRIMNFNFVVQLALLVTTFCPSDAIRYRKDNNINRTDYLDHLLQLQDRKQITDVDIAGHGVSFFADGFETSSIVLTYCLYDLAKHSSIQQQLRETILKAKEVGGGTMSYEQLVEMGLLEQILCETMRIHPLIAVMAKRCTADTTLVGPKDRKIFVKKGTTVVLPYYSVSFDPEHFSDPHKYDPSRFSAENGGSKVYRERGVYFPFGDGPRMCLGMRFAMTQVKRAIVEIVEHFSISVNGKTIEPFEMDPDQFMLMPKGSIWLDFKPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PNC1</accession>
    <name>A0A240PNC1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PNC1"/>
    <dbReference type="STRING" id="199890.A0A240PNC1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015298-RA">
        <property type="protein sequence ID" value="AEPI015298-PA"/>
        <property type="gene ID" value="AEPI015298"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015298"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:hydroxypyruvate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF119">
        <property type="entry name" value="FI03731P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="18"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="115"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015298-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="325" mass="35096" checksum="CA303D9EB78B7E3C" modified="2017-10-25" version="1">MVNSGQRPVVLVTNKETPEKGIHKLKLKCDVIFPKNHPATRDEILELAGQVDGIMWVGHMPLNGEVLDRGGSRLKAISTMSAGMDYVDVEEFRKRKFPLGYTPIVLNDAVADSAIGLMIAAGRRYHEGRLAIDQSQWKGGPQWLLGQDIKGSTVGILGMGGIGQTIAKRLKGFEIGQLLYSGRRTKPEAEALGAKMVPQDELLQESDYVFIAVPLTNETRHMINETTLSKMKPTAVLVNVARGDIVDQKALVAALKNGTIFAAGLDVVTPEPLPAEDELLSLPNAVVIPHLGSATVQTRNNMAEIAALNVLAGIAGTPMFSPYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWJ7</accession>
    <name>A0A3F2YWJ7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWJ7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015437-RA">
        <property type="protein sequence ID" value="AEPI015437-PA"/>
        <property type="gene ID" value="AEPI015437"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015437"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015437-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="146" mass="17109" checksum="7F6D01C37AD0417D" modified="2019-01-16" version="1">MSTIEERTAYLDNPYFKGHIYGNFNPFYVTIAICTVLGVFIFVLNIVCGCCSKHKQYWQDRHTGNRWLVSFWSATPHKQPPLDLTELKDASHFQPVNPDVERPVEYTVQHHRPQYQYPPASVRGASPQGYHHREEYVELQKRESDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9I3FGL9</accession>
    <name>A0A9I3FGL9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-03" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KCMF1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A9I3FGL9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015510-RA">
        <property type="protein sequence ID" value="AEPI015510-PA"/>
        <property type="gene ID" value="AEPI015510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010646">
        <property type="term" value="P:regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02338">
        <property type="entry name" value="ZZ_PCMF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008598">
        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="462"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015510-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="551" mass="58088" checksum="47AE12A6AE6503B6" modified="2023-06-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZM5</accession>
    <name>A0A182NZM5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZM5"/>
    <dbReference type="STRING" id="199890.A0A182NZM5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000106-RA">
        <property type="protein sequence ID" value="AEPI000106-PA"/>
        <property type="gene ID" value="AEPI000106"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000106"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000459">
        <property type="entry name" value="ARM repeat superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="925"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000106-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1034" mass="116273" checksum="463468F77C2A4809" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P039</accession>
    <name>A0A182P039_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase PGAM5, mitochondrial</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phosphoglycerate mutase family member 5 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Serine/threonine-protein phosphatase Pgam5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with Pk92B/ASK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P039"/>
    <dbReference type="STRING" id="199890.A0A182P039"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000271-RA">
        <property type="protein sequence ID" value="AEPI000271-PA"/>
        <property type="gene ID" value="AEPI000271"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000271"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000009">
        <property type="entry name" value="serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051021">
        <property type="entry name" value="Mito_Ser/Thr_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000271-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="286" mass="32487" checksum="2A346728611DA0D6" modified="2016-09-07" version="1">MGVWSRFMTKKLVSGTVIGVVGGASGYWFASKAFEWQTVENSFTTNYEPSPCAKWDWNWDHRDPKSLVKPLKKVDDPEAQNDYNKAVEMKKGRAIRHLILVRHGQYNLDGITDVQRTLTELGRKQAALSGERLKQLALPYDNIVRSTMTRAQETAEIIGKSLPQLKLINCPLLEEGSPIPPEPPVGHWRPEASQFFQDGARIESAFRKYFYRADPSQKSDSYTIIVCHANVIRYFVCRALQYPAEGWLRISLGHASLTWVSIYPDGRVSLRTLGDCGHMPKECLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P082</accession>
    <name>A0A182P082_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P082"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000314-RA">
        <property type="protein sequence ID" value="AEPI000314-PA"/>
        <property type="gene ID" value="AEPI000314"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000314"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130761" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000314-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="661" mass="74690" checksum="E6CB4CD61EDD5674" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0H4</accession>
    <name>A0A182P0H4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P0H4"/>
    <dbReference type="STRING" id="199890.A0A182P0H4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000406-RA">
        <property type="protein sequence ID" value="AEPI000406-PA"/>
        <property type="gene ID" value="AEPI000406"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000406"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF13">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000406-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="90" mass="10146" checksum="3EB7747D4B3FFAAB" modified="2016-09-07" version="1">MRTTSHTTINNNLNNAANNNNQNGTHHVFHLKCFQCSKCGSHLVQGDRYYMLGGSLVCEPDWHKLVKTTNSATNPPLRKGKVGRPRRSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0N9</accession>
    <name>A0A182P0N9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome biogenesis protein BOP1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0N9"/>
    <dbReference type="STRING" id="199890.A0A182P0N9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000471-RA">
        <property type="protein sequence ID" value="AEPI000471-PA"/>
        <property type="gene ID" value="AEPI000471"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000471"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="10">
        <location>
            <begin position="247"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="519"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="773"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000471-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="860" mass="98544" checksum="1EF9D7652AB075D9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1C0</accession>
    <name>A0A182P1C0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI-anchor transamidase component GPAA1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GAA1 protein homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glycosylphosphatidylinositol anchor attachment 1 protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Binds GPI-anchor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heteropentamer. Part of the GPI-anchor transamidase complex, consisting of PIGK, PIGT, PIGS, PIGU and GAA1. Interacts with PIGK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1C0"/>
    <dbReference type="STRING" id="199890.A0A182P1C0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000702-RA">
        <property type="protein sequence ID" value="AEPI000702-PA"/>
        <property type="gene ID" value="AEPI000702"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000702"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000047">
        <property type="entry name" value="Glycosylphosphatidylinositol anchor attachment 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036762">
        <property type="entry name" value="GAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000702-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="637" mass="70844" checksum="D12015D4F62158AC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1H8</accession>
    <name>A0A182P1H8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1H8"/>
    <dbReference type="STRING" id="199890.A0A182P1H8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000760-RA">
        <property type="protein sequence ID" value="AEPI000760-PA"/>
        <property type="gene ID" value="AEPI000760"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000760"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="4">
        <location>
            <begin position="94"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="5">
        <location>
            <begin position="500"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="6">
        <location>
            <begin position="636"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000760-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="825" mass="94236" checksum="FB1A406557194B2B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1J1</accession>
    <name>A0A182P1J1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1J1"/>
    <dbReference type="STRING" id="199890.A0A182P1J1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000773-RA">
        <property type="protein sequence ID" value="AEPI000773-PA"/>
        <property type="gene ID" value="AEPI000773"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000773"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000247">
        <property type="entry name" value="28S ribosomal protein S25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000773-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="168" mass="19334" checksum="1A32D92DD7831884" modified="2016-09-07" version="1">MPFMKGKAPIRRTLQYLNAGQLMLKDKVKIFSVNYNTYGEHHEGARDFVFWNIPQIQYKNPKVQVVTFKNMTPSPFIRCYFENGKQMLIDIDSKNRQEILQHLTTVVGKSDETLKAEAKLAEKQDNPANFGVGCMKHCICEIPGQLPCPGVVPVPKHMRGKFKYQMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1P1</accession>
    <name>A0A182P1P1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TNF receptor-associated factor 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1P1"/>
    <dbReference type="STRING" id="199890.A0A182P1P1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000823-RA">
        <property type="protein sequence ID" value="AEPI000823-PA"/>
        <property type="gene ID" value="AEPI000823"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000823"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000007">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000121">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000169">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012227">
        <property type="entry name" value="TNF_rcpt-assoc_TRAF_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015614">
        <property type="entry name" value="TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="9">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="9">
        <location>
            <begin position="94"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="9">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="8">
        <location>
            <begin position="245"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="94"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000823-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44895" checksum="90A3107DDA335BBA" modified="2016-09-07" version="1">MPKIYPDPESEKAIMGSLVFCIHHKQGCKWSDELRKLKAHLNTCKHDAIQCPNKCGSQIPRVMMTDHLAFTCILRRAICEFCNVEFTGIGLEEHAGTCSSEPIYCESKCGTRVLRGRMSIHRAKDCAKRLRRCPHCGREFSADTLAAHGATCPRSPVPCPQRCDAGPFARAELDAHLRDECKALTVPCTFKEAGCRFKGPRHLLEAHLEANTSAHLSLMVALSGRQGQQINMLKSAMAKLSTNYTGTLLWKITDWSVKMQEAKTKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGEGTHVSVYIKVLPGEYDALLKWPFSHSVTFTLFEQGTLGSGGGGQGGVAESFVPDPTWENFQRPSTEPDALGFGFPRFVSHELLNRRPFVRDDTVFLRVKVDPSKIVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2L5</accession>
    <name>A0A182P2L5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2L5"/>
    <dbReference type="STRING" id="199890.A0A182P2L5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001149-RA">
        <property type="protein sequence ID" value="AEPI001149-PA"/>
        <property type="gene ID" value="AEPI001149"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001149"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016360">
        <property type="term" value="P:sensory organ precursor cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19715">
        <property type="entry name" value="bHLH_TS_amos_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000025">
        <property type="entry name" value="protein atonal homolog 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF169">
        <property type="entry name" value="PROTEIN ATONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="253"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001149-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="310" mass="33944" checksum="24A17363889092E9" modified="2016-09-07" version="1">MTSDFGRHAPFYYYGHDPVVPSCGSVNVKMEQLEVPSSLAESSYLSTSYSYATNTATTTSANTTNIVSQSSAAPNVVILPGYMDNYPDSWMTPSPSSFGSESPDYYSLANSPQRSFVDVEEYKENLLAMQQTSQLPGLLTTATLPLSPPLHTNSQVQPTSNVPTAPSTNLPVKKRQYNRKPKAKPEPTKAAETDASSRADLSCLTFPKGLYPKTVETPSGHPEGSVGSTGNGTVAGAMGKRKRKQVPPQIKKKRRLAANARERKRMQNLNDAFDRLRQYLPSLGNDRQLSKHETLQMAQTYITALCDLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2S2</accession>
    <name>A0A182P2S2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2S2"/>
    <dbReference type="STRING" id="199890.A0A182P2S2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001208-RA">
        <property type="protein sequence ID" value="AEPI001208-PA"/>
        <property type="gene ID" value="AEPI001208"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001208"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001208-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="387" mass="44039" checksum="4F0FEEED4B4BD775" modified="2016-09-07" version="1">MVLFEPHNDPLKILPLSLKLFASIGVSGNPADRVRLYGSYFYLCFVQFVPKLCMGYETIPQCFRSIAEGMFSFNTCVTIVLLPLRFGQFESLLQDLKRFTELVSTNEEYKQILVTLNTAIHKFTKYYFIFTNIIVVAMTCSSFAGVLYTYFLRKSNQSAVYPLIMEHRIYVLDAKRNLAHCFIHQVLILLALYILLVAFVAKAGAFCGSIRFCSTVLEIVALKIDRLSLLVSGEQYVGELREIILLHQLAIKCAKQLQGILMEILLAQFTGCVLIWCFMLYSVMISGITAEGITVMAMLTAFSTETFMFCLLGNELTLKGEQIGAAMYASNWYEQPVQIQKLIVPILQQSQQRIGISAAKFYYIDYNRYGLSLKTAYSFYLLLKDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P368</accession>
    <name>A0A182P368_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="AlphaFoldDB" id="A0A182P368"/>
    <dbReference type="STRING" id="199890.A0A182P368"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001352-RA">
        <property type="protein sequence ID" value="AEPI001352-PA"/>
        <property type="gene ID" value="AEPI001352"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001352"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000736">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000037">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000153">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000234">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF274">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="592"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="946"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="883"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001352-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1154" mass="129691" checksum="8716E19A84FBA431" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3J1</accession>
    <name>A0A182P3J1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ras-related GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P3J1"/>
    <dbReference type="STRING" id="199890.A0A182P3J1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001476-RA">
        <property type="protein sequence ID" value="AEPI001476-PA"/>
        <property type="gene ID" value="AEPI001476"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001476"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000001">
        <property type="entry name" value="Ras-related GTP-binding protein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000226">
        <property type="entry name" value="Ras-related GTP-binding protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001476-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="43446" checksum="A161D26600AC4C8C" modified="2016-09-07" version="1">MSYQDEEEQVGSFPKDFGYGDFDHESDGNRPSDDKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIVKDDINNNSFVQFQIWDFPGQIDFFDPTFDSDMIFGGCGALVFVIDAQDDYVEALTKLNQTVTKAHKVNPRIKFEVFIHKVDGVSDDFKMESQRDIHSRATDDLIDAGLEGVHLNFHLTSIYDHSIFEAFSKVVQKLIPQLAALENLLNLFIHNSGIEKAFLFDVVSKIYIATDATPVDMQSYELCCDMIDVVIDLSCIYGSRDNPDVPAFDNQSSSIIKMNNSTVLYLREVNKFLALVCIIREESFSRQGVIDYNFLCFREAITQVFELRFKQQKLEAIEQDSDNLDDLRDFGRGDVISSMKRFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P425</accession>
    <name>A0A182P425_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182P425"/>
    <dbReference type="STRING" id="199890.A0A182P425"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001661-RA">
        <property type="protein sequence ID" value="AEPI001661-PA"/>
        <property type="gene ID" value="AEPI001661"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001661"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF52">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="194"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="553"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001661-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="599" mass="66616" checksum="FB7360E26DCC4C51" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P426</accession>
    <name>A0A182P426_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase aquarius N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P426"/>
    <dbReference type="STRING" id="199890.A0A182P426"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001662-RA">
        <property type="protein sequence ID" value="AEPI001662-PA"/>
        <property type="gene ID" value="AEPI001662"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001662"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="1">
        <location>
            <begin position="30"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001662-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="314" mass="37456" checksum="771B807D016E4F36" modified="2019-01-16" version="2">MMVPQDENQVQDKQVLKGAITISQIDADEITFLANRFWAPDTSNAHEPYNPRIIEDIYRKEICDSRHSLRRIMMLEFSQYLENYLWPNFDGESASRAHLMSIVAMVNEKFREKVEVWKVFEKSSDLFAKFFQRVLEACIEERPVTPAVMREQTALLVFLNHCFNSMEVEICRNQAKRLVSLAMWSCLQPKRREQELNQTPQWRKFWKKLQKREDPEQKEKLSWERHFLQNLMIKFIRVLDTIPEDGPICEETVRYCERFVEFLIDLEALLPTRRFFNTVMDDCHVVVRCSLSSLVRREEGNLFSQVSCITEYCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4F3</accession>
    <name>A0A182P4F3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182P4F3"/>
    <dbReference type="STRING" id="199890.A0A182P4F3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001789-RA">
        <property type="protein sequence ID" value="AEPI001789-PA"/>
        <property type="gene ID" value="AEPI001789"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001789"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025848">
        <property type="entry name" value="MT-A70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51563">
        <property type="entry name" value="SAM_MTA70L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001789-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="650" mass="72387" checksum="2BAC03ACB81425B0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P585</accession>
    <name>A0A182P585_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P585"/>
    <dbReference type="STRING" id="199890.A0A182P585"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002073-RA">
        <property type="protein sequence ID" value="AEPI002073-PA"/>
        <property type="gene ID" value="AEPI002073"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002073"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF2">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="245"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="800"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="833"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="869"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002073-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="925" mass="104879" checksum="833F2437F360B7A3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P5L7</accession>
    <name>A0A182P5L7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P5L7"/>
    <dbReference type="STRING" id="199890.A0A182P5L7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002207-RA">
        <property type="protein sequence ID" value="AEPI002207-PA"/>
        <property type="gene ID" value="AEPI002207"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002207"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF241">
        <property type="entry name" value="CUTICULAR PROTEIN 47EG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130876" evidence="3">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002207-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="146" mass="15885" checksum="D108601B065D1E87" modified="2016-09-07" version="1">MKMFVALFAVFAVASAIGDYHHQPTGAPIKIVHSESYHGHDGSYKFGYESANGIAAQEQGFVKNGGSKDHEVQVAHGSFSYTDPHGHPVSLSYVADEHGFQAKGSHIPTPPPVPKELVDAYAKAASQPHHEEPQPHYAPQPTYKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P6W4</accession>
    <name>A0A182P6W4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P6W4"/>
    <dbReference type="STRING" id="199890.A0A182P6W4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI002664-RA">
        <property type="protein sequence ID" value="AEPI002664-PA"/>
        <property type="gene ID" value="AEPI002664"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI002664"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI002664-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1193" mass="135294" checksum="C40F090A128FB2FD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P868</accession>
    <name>A0A182P868_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P868"/>
    <dbReference type="STRING" id="199890.A0A182P868"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003121-RA">
        <property type="protein sequence ID" value="AEPI003121-PA"/>
        <property type="gene ID" value="AEPI003121"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003121"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12353">
        <property type="entry name" value="RRM2_TIA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000419">
        <property type="entry name" value="CLUMA_CG006354, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000317">
        <property type="entry name" value="Rox8, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="96"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="206"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003121-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="455" mass="49002" checksum="31B1A31AAC48E87D" modified="2016-09-07" version="1">MTEESYPKTLYVGNLDTSVTEELLCTLFSQMGTVKSCKIIRETSIDPFAFIEYANHQSAQTALAAMNKRMFLKKEIRVNWATSAGNQPKTDTSQHHHIFVGDLSPEIDTETLREAFAPFGEISNCRIVRDPQTLKSRGYAFVSFVKKAEAENAITMMNGQWLGSRSIRTNWSTRKPPAPRENSKGIKSGKTPGFEEIYNNTSPTNTTVYCGGFPPNAITDELIQKHFAQFGHINDTRVFKDKGYAFIRFANKESAARAIEGTHNSEVQGHPVKCYWGKENGGDVNSNGMNPSAIAAAAAASGMIGMNMNGIVSPLQPMQPNAAAAAAAVAQQHSANPQLTQASAAAAAAAAAAGAQYPYSAAYGQMAYWIPGGYPQIQTQYMQQGYYTYPTAYAPAAPQQSGYRMMQPNMAAGWGMQTVPTVATNGAAAAAAAAAAAASSQQPVMYATMPQFQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8H8</accession>
    <name>A0A182P8H8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000050">
        <property type="entry name" value="MGC157082 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AA/rel_permease1"/>
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    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
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    <dbReference type="PANTHER" id="PTHR43243:SF105">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="82"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="94"/>
            <end position="112"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="340"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="387"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="414"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="492"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="558"/>
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    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="7">
        <location>
            <begin position="535"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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    </feature>
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        <location>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13906"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003231-PA"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1314" mass="144235" checksum="944BF51941687683" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8I8</accession>
    <name>A0A182P8I8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Semaphorin-1A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the semaphorin family.</text>
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    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
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        <property type="entry name" value="Semap_dom"/>
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    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF127">
        <property type="entry name" value="SEMAPHORIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sema" evidence="14">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="594"/>
            <end position="603"/>
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    </feature>
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        <location>
            <begin position="618"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="752"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="796"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="849"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="918"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="933"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003241-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="972" mass="105643" checksum="B7600757CFD4FCA7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8R9</accession>
    <name>A0A182P8R9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Uridine kinase</fullName>
            <ecNumber evidence="17">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">May contribute to UTP accumulation needed for blast transformation and proliferation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="17">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with RNF19B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A182P8R9"/>
    <dbReference type="STRING" id="199890.A0A182P8R9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003323-RA">
        <property type="protein sequence ID" value="AEPI003323-PA"/>
        <property type="gene ID" value="AEPI003323"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003323"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000200">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="19">
        <location>
            <begin position="122"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="20">
        <location>
            <begin position="350"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003323-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="564" mass="63097" checksum="3454B6B554903631" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P8T4</accession>
    <name>A0A182P8T4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A182P8T4"/>
    <dbReference type="STRING" id="199890.A0A182P8T4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003338-RA">
        <property type="protein sequence ID" value="AEPI003338-PA"/>
        <property type="gene ID" value="AEPI003338"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003338"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000054">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="52"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003338-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="342" mass="38313" checksum="545041EFEA496AA3" modified="2016-09-07" version="1">MPVACASGCGRNAFMRRPKTGDTLCKECFFLAFETEIHNTIQQEQLFRPGEKVAIAASGGKDSTVLAHVMNVLNKRYNYGLELVLLSIDEGITGYRDDSLKTVAQNRDDYGMPLRVLSYQELYGWTMDRIVAEIGRSNNCTFCGVFRRQALDRGARLMEVDCVATGHNADDIAETVIMNILRGDTARLRRCCDIKTGSKEADTIPRVKPLKYSYEKEIVMYAHFKKLVYFSTECVFAPNAYRGHARAFLKDLEKVRPSAIMDIIHAGEQLQIKGTVKKPVRGVCGRCGFVSSQQPCKACVLLEGLNRGLPKLGIGKKSKGERMVALQEQQLREKAHLVKNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P938</accession>
    <name>A0A182P938_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P938"/>
    <dbReference type="STRING" id="199890.A0A182P938"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003442-RA">
        <property type="protein sequence ID" value="AEPI003442-PA"/>
        <property type="gene ID" value="AEPI003442"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003442"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="10">
        <location>
            <begin position="368"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003442-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1058" mass="113114" checksum="D615DB55DF9FBEF1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P995</accession>
    <name>A0A182P995_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P995"/>
    <dbReference type="STRING" id="199890.A0A182P995"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003499-RA">
        <property type="protein sequence ID" value="AEPI003499-PA"/>
        <property type="gene ID" value="AEPI003499"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003499"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003499-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="312" mass="31625" checksum="95A8E99CE6B6DBB5" modified="2016-09-07" version="1">MENSLARQTSRPRSVKLYLPTDYCCLPAPVVNAEHAEPSSLSNVGNTRCQDSHGPTVEFKTNCAGTGPIGGVLGGAASVPGSGGGGGGVGLGCIGGGGGVGPDVGLANGTPLGLSPTSAAVSSDSQQFNIFPAIFSRQLNFNTSTGSCSQSKLMDDLRPNLVGGLLGLQQGLLDDHAALAHGGNLSQHNAGQDSKFMSLQDNRLMGIASHENRLLGLGSQDHGRGGVGGPAGGANGDKSIGQHRKCSSTPEDFSALYGGLAGTPISDHHHHHTPAHTPPNRLSDNGSVTGPNPVDCTRQGLLCLYTEAIEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9G0</accession>
    <name>A0A182P9G0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P9G0"/>
    <dbReference type="STRING" id="199890.A0A182P9G0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003565-RA">
        <property type="protein sequence ID" value="AEPI003565-PA"/>
        <property type="gene ID" value="AEPI003565"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003565"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003565-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="242" mass="26005" checksum="1248BB0E416F60C3" modified="2016-09-07" version="1">MLDSELYPRAGDTHHGQHGHHHHHHHHHHHYKSPHHRHYHSPSPQHHHHQERERKSRSSPRHHHLQHSDGEKLKYQNAFGGSVGNIGGASASEKYHKFFPHNLLSGGGSGTGGGGGYFDLSDKLDSLNLGGGGSRGSEKSSLISGSGGSSAVSGGGDSNNNHERQHTSGSASILSDTTAAGSGSNASGASSSKKRTIVLVGDGRSRVRRVVRTQTRQITVVSYSGRKKETETHTSHHATIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9H8</accession>
    <name>A0A182P9H8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor IIIC subunit 5 HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P9H8"/>
    <dbReference type="STRING" id="199890.A0A182P9H8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003583-RA">
        <property type="protein sequence ID" value="AEPI003583-PA"/>
        <property type="gene ID" value="AEPI003583"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003583"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003583-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="253" mass="29472" checksum="A8DE9E59A5C707C2" modified="2016-09-07" version="1">MLAARVIPLEDVEKVRNAFKIRPIWTRNALVNINKLVIHSQTLGLILPSVAFYYVNGPWRGTWVRYGYDPRKHFDARAYQLLDFRVRAIGSLHEYIKIKRLSLTKINYRTAEPTASIKDDEPNFISSTFDEDTIPPHRVIFYQYCDINLKKIQEMLKKVPSPLSGTVCDERYGWLPYRFDDQCRNIMMEIVLNNIRRLREANPEACRAIESVEEDEDEGDEAEISGFEEEEDDDDDDDGEQEGILDSLDDMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9R5</accession>
    <name>A0A182P9R5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P9R5"/>
    <dbReference type="STRING" id="199890.A0A182P9R5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003669-RA">
        <property type="protein sequence ID" value="AEPI003669-PA"/>
        <property type="gene ID" value="AEPI003669"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003669"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="152"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003669-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="223" mass="24006" checksum="97F6BEF5776B3C26" modified="2016-09-07" version="1">MACNKENRKLFKVPTSSVPATTGIPSHSGTLLVKKGTALVGSVGSTALKINSVSKVVGKSGEGTQQQQQHMGGFKAPQLPPSVSRPVVAASSRPVAIKPSVPKTEETQTDEPMDTTPSGGQPETAQKQSNTNDEGSSDQQKPAKKVWTLSNFDIGRPLGRGKFGNVYLAREKETKFVIALKVLFKKQVAAHLISRLLVKDPANRMPLENVAIHPWIQLHVDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9X0</accession>
    <name>A0A182P9X0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Retinol dehydrogenase 12</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P9X0"/>
    <dbReference type="STRING" id="199890.A0A182P9X0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003724-RA">
        <property type="protein sequence ID" value="AEPI003724-PA"/>
        <property type="gene ID" value="AEPI003724"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003724"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003724-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51925" checksum="C2B4C5821AE47E16" modified="2016-09-07" version="1">MTNQEQHQQLPEQKQKHHQQQAIAITIRDTCTTSEGVTGERKVKLIVNRSSPVVSSHTRTDPSAVPVVSSIPTPTVPSMSIPPLPQSLDASPHHPQQPSHPPQQQPQPLPSHPNQHPLQYQLHQLHQQQQYQQRQQQQHDLFMIVSICLGSFILIFAIVYFVRKFFQGGQFKNKDIRLDAKVVIITGANAGIGKEAAIECAKRGARVYMGCRDPARMEKARQEILDKSGSQNVFGLELDLASFESIRSFVKTFLSMERRLHVLINNAGVMACPKAYTKEGFEMHFGTNHLGHFLLTNLLLDVLKRSAPSRIVTVSSLGHKWGRINKDDINAEKDYREWDAYMQSKLCNILFSRHLAKRLRGTGVNTYALHPGAINTELTRHLNPCFRTMAKPVFWVFFKTPKSGAQTTLYCAMEPTIASQTGLYYSDCKLKEPEPHAKDDAMAEWLWNLSERLTGLSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P9X1</accession>
    <name>A0A182P9X1_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P9X1"/>
    <dbReference type="STRING" id="199890.A0A182P9X1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003725-RA">
        <property type="protein sequence ID" value="AEPI003725-PA"/>
        <property type="gene ID" value="AEPI003725"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003725"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009832">
        <property type="entry name" value="DUF1397"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20997">
        <property type="entry name" value="EG:BACR42I17.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20997:SF2">
        <property type="entry name" value="EG:BACR42I17.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07165">
        <property type="entry name" value="DUF1397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131011" evidence="1">
        <location>
            <begin position="30"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003725-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="564" mass="61850" checksum="443E819C3A05A73A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAG9</accession>
    <name>A0A182PAG9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein max</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myc-associated factor X</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAX family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAG9"/>
    <dbReference type="STRING" id="199890.A0A182PAG9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003923-RA">
        <property type="protein sequence ID" value="AEPI003923-PA"/>
        <property type="gene ID" value="AEPI003923"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003923"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11406">
        <property type="entry name" value="bHLHzip_Max"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000023">
        <property type="entry name" value="MAX isoform 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="13">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="175"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003923-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="213" mass="24229" checksum="5CFAF07E6D1CCC6D" modified="2016-09-07" version="1">MRKYKSSNTALRSIVESNSPWMRLHEDNQGRKQSTAEWYDMSDDDRDIDIESDDGDDSDNTKSQSRSGAGSQFYSQAEKRAHHNALERKRRDHIKDSFTSLRDSVPSLQGEKASRAQILKKAAEYIQFMRRKNNSHQQDIDDLRRQNNMLESQIRHLEQARATGNFADGADLGLAFQDGSRGSDSSDIDEVPANNNNGLGARRNKKMKTNANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAL2</accession>
    <name>A0A182PAL2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PAL2"/>
    <dbReference type="STRING" id="199890.A0A182PAL2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI003967-RA">
        <property type="protein sequence ID" value="AEPI003967-PA"/>
        <property type="gene ID" value="AEPI003967"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI003967"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="75"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI003967-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="346" mass="38297" checksum="2DA0D3416D553718" modified="2016-09-07" version="1">SLRECEAEQRCVQLAQCGQYLHYVNEAPKYWPPSVREEALRQLCDVQRAVNGSKIYYICCNRKEILCGVTRVQLIAYGQQARAYAFPWMALLETAVTDDLPCGGSLINDRHILTAAHCVKARKITGVRVGVHNVNASQSDCDDRIHFKDDEYDSDESSEESAAEYSASCGPPAQRIPIEKIVIHPKYSARSKRNDLAVIRLQYPAVIGYTVIPICLPLTEQLRAYRPSDSFVTGWGLTETGERSAVLRYAVMPAVSLPDCAMRIKELDRVIVLDDGHLCAGGNNKTAHCHGDSGGPLQYVSDSTRFVLQGVVSFGVKTCGTKIAPGIFANVTHFIDWIVQEANMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAV6</accession>
    <name>A0A182PAV6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acylphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-10" db="UniProtKB">
            <authorList>
                <consortium name="VectorBase"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A182PAV6"/>
    <dbReference type="STRING" id="199890.A0A182PAV6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004061-RA">
        <property type="protein sequence ID" value="AEPI004061-PA"/>
        <property type="gene ID" value="AEPI004061"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004061"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000011">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029:SF10">
        <property type="entry name" value="GEO08407P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004061-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="103" mass="11304" checksum="8FBD0A7ED70EB33B" modified="2016-09-07" version="1">MGVQDLQDHVLVQCDFEIFGQVQGCGFTKCCRDNCLALGIKGWVKNSKQGTIMGKMQGAKGDVGKMVDWLSKTGSPGCKIDKAEFTNWGTCSRLAFTDFAIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PAX4</accession>
    <name>A0A182PAX4_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PAX4"/>
    <dbReference type="STRING" id="199890.A0A182PAX4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004079-RA">
        <property type="protein sequence ID" value="AEPI004079-PA"/>
        <property type="gene ID" value="AEPI004079"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004079"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001312">
        <property type="entry name" value="AGAP011387-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="369"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004079-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="406" mass="44655" checksum="02B1CA1F7A76CDE7" modified="2016-09-07" version="1">MRENTPPRSPLDELVEDGESDDELIYAGDADEVLDAWERDMNHWEEEAGIEEAEEAHTPHREPAQDDARLTFSKHTSSVFCCDLHPTEELAVTGGEDDKAYVWSTRTGEVVHEVTNHGDSVVAVGFSYDGVFVATGDMAGYIQVFKVSQGYRKVWELTVGDIGWMRWHMGAHVLMAGCESGEVYVWRIPSGDCKVLPGNDIGTEAAELTHDGKKLLVGYQNGQVKLWDLKLGTPILEVDSTVGHKGNVTTVAVDQESQLFMTGCEDGSLCLMGPNGVLAQLEQPNPNPIEAVLIDYPGFEIKVAASGTLDGKLTIWDAARQTRRVVCEDDDPVGIIKLLWLKDYIICAGTVDGLIKGWDFRSGAKRFVLEGHKNIIQSIAYDKQRNVILSTSEDGTAKIYDVPTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBR2</accession>
    <name>A0A182PBR2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBR2"/>
    <dbReference type="STRING" id="199890.A0A182PBR2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004367-RA">
        <property type="protein sequence ID" value="AEPI004367-PA"/>
        <property type="gene ID" value="AEPI004367"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004367"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="150"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004367-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="518" mass="59326" checksum="D035C16282A23168" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBU2</accession>
    <name>A0A182PBU2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PBU2"/>
    <dbReference type="STRING" id="199890.A0A182PBU2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004398-RA">
        <property type="protein sequence ID" value="AEPI004398-PA"/>
        <property type="gene ID" value="AEPI004398"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004398"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004398-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="86" mass="9893" checksum="21AA0E4A4568865C" modified="2016-09-07" version="1">MYGVASAPAIFQRLMEEILQGVPGVTVFINDIRVTGPNTNVHLLRLEEVLRRLQKYGLRRNKEKCDFFSDRIEYCGYMNILVSEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBV1</accession>
    <name>A0A182PBV1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PBV1"/>
    <dbReference type="STRING" id="199890.A0A182PBV1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004407-RA">
        <property type="protein sequence ID" value="AEPI004407-PA"/>
        <property type="gene ID" value="AEPI004407"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004407"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000047">
        <property type="entry name" value="Prestin-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="329"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004407-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="457" mass="50047" checksum="836CD64E3B7D64AA" modified="2016-09-07" version="1">MGAASFLLSEALVSGFTTGAAVYVFTSQMKDILGVTLPPLGSKFEIVYTYYELGKKVPDTNLVNLGIAIVAIIILLINNEIIKPRLAKLCIIPIPIQLILVVSGTLLSIQFSLKENYGIKVVGTIPQGLPAPKIPNFDILPEILMESITVAVVGYTVSVSLGIIFAKKENYEIGFNQELLALGAGNVFGSFFSCYPFAASLSRAAIQYLAGGKTQITGLVSCSLLAVVLLFVASFFQPLPRCILASIIAVSVQGLLMQAKDLPKFWRQGFFDGVTWVLTFVSVVFISIDIGLLVGFALSVSSIFFRALKPYMCQLGNVPNSDVYLDVTRYEGLIEHRGIKIIHYSGGLHFASRAIFKSTICQFLNINLTEETKRRKAPDFVETDDAIKYLILDFTALSYIDPSAISTFKTFIRDLEAIDVQTLLAGCSPLVFEKMKKCNFIGGEENYVRTYPTVHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PBZ8</accession>
    <name>A0A182PBZ8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="4">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A182PBZ8"/>
    <dbReference type="STRING" id="199890.A0A182PBZ8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004454-RA">
        <property type="protein sequence ID" value="AEPI004454-PA"/>
        <property type="gene ID" value="AEPI004454"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004454"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000104">
        <property type="entry name" value="Mitochondrial tRNA-specific 2-thiouridylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.280:FF:000001">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="13">
        <location>
            <begin position="213"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004454-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="339" mass="38564" checksum="3FC92C6A0BE41A44" modified="2016-09-07" version="1">MFRRVVVGISGGVDSAVSAYLLKKQGFEVCGAFMKNWDLIDEAGYCSGEQDLEDAQRLCRMLSIPLEEINFVKDYWVEVFGNFLKDYEAGITPNPDILCNRHIKFNRFFRHARERLGADAIATGHYARTNFGPFLERYNPNEKVRLLMAPDPIKDQTFFLSQISAEALRHTMFPVGALTKPQVKQLATEVGLDAYARKKESMGICFVGKRSFQQFIGEYIETKPGPFMDVDSGREVGRHAGLHHWTVGQKCKIGGCLQPYYVLRKHRETNVIEVASGHDHPLLYTDMVYAEQPVWINAPPGLAEGQVVRFEFRFQHTKPLLFPIPKYLYEPACTDATDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCH9</accession>
    <name>A0A182PCH9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">ATP-citrate synthase</fullName>
            <ecNumber evidence="19">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Citrate cleavage enzyme</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5 19">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="19"/>
    <dbReference type="AlphaFoldDB" id="A0A182PCH9"/>
    <dbReference type="STRING" id="199890.A0A182PCH9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004634-RA">
        <property type="protein sequence ID" value="AEPI004634-PA"/>
        <property type="gene ID" value="AEPI004634"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004634"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000004">
        <property type="entry name" value="ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000009">
        <property type="entry name" value="ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014608">
        <property type="entry name" value="ATP-citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036511">
        <property type="entry name" value="ATP_citrt_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 19" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="24">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="23">
        <location>
            <begin position="243"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="22">
        <location>
            <begin position="647"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="443"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="20">
        <location>
            <position position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR036511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR036511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004634-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1087" mass="119199" checksum="7ED070F9622AED5F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCP0</accession>
    <name>A0A182PCP0_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCP0"/>
    <dbReference type="STRING" id="199890.A0A182PCP0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004695-RA">
        <property type="protein sequence ID" value="AEPI004695-PA"/>
        <property type="gene ID" value="AEPI004695"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004695"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.200">
        <property type="entry name" value="Ran-GTPase activating protein 1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036720">
        <property type="entry name" value="RanGAP1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69099">
        <property type="entry name" value="Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004695-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="592" mass="65337" checksum="E8BBB12340E68B9F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCQ2</accession>
    <name>A0A182PCQ2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Beta-4-GalNAcT</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A182PCQ2"/>
    <dbReference type="STRING" id="199890.A0A182PCQ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004707-RA">
        <property type="protein sequence ID" value="AEPI004707-PA"/>
        <property type="gene ID" value="AEPI004707"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004707"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF48">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="85"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="193"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004707-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="317" mass="37372" checksum="15EAB5EBFA5B6964" modified="2016-09-07" version="1">MITFRLSNSVYAYVGYLLLMVYFLWPGRFASLYDYIEGENIYDQLIRKTTKNISLMRNGLRCDYSEVIEENLSLYRPPYTEDIINNNVRIGGEYYPEDCLPSFSTAIIIPYRQRERQLNQFLIYMHNYLRRQRIHYRIFVIEQYDPKPFNRAKLFNIGAMIAVGFDYPCLVLHDVDLMPMNLGHLYACSRKPRHMCSSLDVFRYNLPYRGLFGGAVAIESSVYLNINGMSNMFSGWGGEDDDLYGRLQNKQIEICRFSPEYSQYSMLKHRKETPNKDRVAFLKNGKQRYHTDGLNSLVYKQVGFKLHNLFTHVLVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PCY2</accession>
    <name>A0A182PCY2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PCY2"/>
    <dbReference type="STRING" id="199890.A0A182PCY2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004787-RA">
        <property type="protein sequence ID" value="AEPI004787-PA"/>
        <property type="gene ID" value="AEPI004787"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004787"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039139">
        <property type="entry name" value="CCDC170-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18863:SF6">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18863">
        <property type="entry name" value="TSEC-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="540"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI004787-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="778" mass="88613" checksum="D33EAD0A0F2C323D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PD90</accession>
    <name>A0A182PD90_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="10"/>
    <dbReference type="STRING" id="199890.A0A182PD90"/>
    <dbReference type="EnsemblMetazoa" id="AEPI004895-RA">
        <property type="protein sequence ID" value="AEPI004895-PA"/>
        <property type="gene ID" value="AEPI004895"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI004895"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000033">
        <property type="entry name" value="E3 ubiquitin-protein ligase hecd-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000022">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000051">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000085">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000014">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000044">
        <property type="entry name" value="E3 ubiquitin-protein ligase Ufd4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000007">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000372">
        <property type="entry name" value="Putative hect e3 ubiquitin ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="423"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="13">
        <location>
            <begin position="1500"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="12">
        <location>
            <begin position="2732"/>
            <end position="3186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="247"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="677"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="795"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="908"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1639"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1694"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1798"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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</entry>
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                <person name="Howell P."/>
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                <person name="Haas B."/>
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                <person name="Allen A.W."/>
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                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Larimer J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Epiroticus2</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">Epiroticus2</strain>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="10">Epiroticus2</strain>
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        </source>
    </evidence>
    <sequence length="440" mass="48785" checksum="CFB91775598B9AE2" modified="2016-09-07" version="1">MNFRQGLNDTTARSEAKGTRPTATPTSIREVLTMMVLHVCKKIIFFDTNLKVPLYLGSLFIVSLIGDFLPYPKTYLARTDNLFNVYFVKLGWAWTLLFTFPYLAMTSITICCGDNQRLIRNHLPRLGIATVFWFVWTKLFNIIESSYGRCSVRGFDAKTACLKAGHLWNGFDISGHAFILIYASLVLMEEARPIIGWESIKDLLRNEEHNRSNNDKSQTSNPLKSLKDEDLKALKYFYNRFTPTIRLFFVGMTMLQLLWDLMLVGTMLYHHRMAEKVLSGIIAVVTWFVTYRAWYPIPTVLPDPVGKGLFNYQSINKSEIGLRRRASLLQPGSSATAGAGSGKEIPTFMGMPLYAARAQTSGSSVGAGASPLEGSASGQQAAFVSSHLYGSRIGTGSGGISGNSSSGAGSGGGGGSYYSNPDFNHPSYARYRSRFERFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PDT4</accession>
    <name>A0A182PDT4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="19">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase that is required for specification of R7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk). E3 Ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cells in the eye, leading to the differentiation of cells into neurons. Also involved in external sensory organ development.</text>
    </comment>
    <comment type="function">
        <text evidence="19">E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 19">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of some E3 complex at least composed of sina, ebi and phyl. Interacts with eff.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="19">The RING-type zinc finger domain is essential for ubiquitin ligase activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="19">The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="19"/>
    <dbReference type="AlphaFoldDB" id="A0A182PDT4"/>
    <dbReference type="STRING" id="199890.A0A182PDT4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005089-RA">
        <property type="protein sequence ID" value="AEPI005089-PA"/>
        <property type="gene ID" value="AEPI005089"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005089"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16752">
        <property type="entry name" value="RING-HC_SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03829">
        <property type="entry name" value="Sina"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000063">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000041">
        <property type="entry name" value="E3 ubiquitin-protein ligase SINAT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018121">
        <property type="entry name" value="7-in-absentia-prot_TRAF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03145">
        <property type="entry name" value="Sina_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="15" id="KW-0844">Vision</keyword>
    <keyword evidence="13 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 18 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="22">
        <location>
            <begin position="95"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU201113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005089-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="284" mass="31296" checksum="BB619D5EE7D42E53" modified="2016-09-07" version="1">MSNKLNNPKRREVTGSSSSNSSISSVGAGDNGISADLASLFECPVCFDYVLPPILQCQSGHLVCTSCRSKLTCCPTCRGSLGNIRNLAMEKVASNVKFPCKHSNHGCTISLVYTEKAEHEEACEFRPYLCPCPGASCKWQGSLDYVMPHLMMSHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYDGHQQFYAIVQLIGSRKEAENFAYRLELNGNRRRLTWEAMPRSIHEGVASAILNSDCLVFDTSIAQLFADNGNLGINVTISVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEN2</accession>
    <name>A0A182PEN2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Galectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TECPR1 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PEN2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005387-RA">
        <property type="protein sequence ID" value="AEPI005387-PA"/>
        <property type="gene ID" value="AEPI005387"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005387"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="entry name" value="Peroxin/Ferlin"/>
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        <property type="entry name" value="Tectonin_beta-prop"/>
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        <property type="entry name" value="Znf_MYND"/>
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        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hyd_WA"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Tectonin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DysFN"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TECPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Galectin" evidence="11">
        <location>
            <begin position="801"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="1382"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="1416"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="10">
        <location>
            <begin position="1664"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005387-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1735" mass="192596" checksum="F883F5FF7D977A69" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEQ9</accession>
    <name>A0A182PEQ9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein 8A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RBM8A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PEQ9"/>
    <dbReference type="STRING" id="199890.A0A182PEQ9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005414-RA">
        <property type="protein sequence ID" value="AEPI005414-PA"/>
        <property type="gene ID" value="AEPI005414"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005414"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000157">
        <property type="entry name" value="RNA-binding protein 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="71"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005414-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="164" mass="18966" checksum="DD2DF5CB4DBC4085" modified="2016-09-07" version="1">MADVLDIYNHEEFEVDEDGDQGIARLKEKARKRKGRGFGNESIPRETIDYERLQDDEEEAEPGPQRSVEGWILFVTSIHEEAQEDDIQEKFCEFGDIKNIHLNLDRRTGFLKGYALVEYETYKQALAAKEALNGSEVLGQTIAVDWCFVKGPKKLKKSSERRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PEZ3</accession>
    <name>A0A182PEZ3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
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        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="9">
        <location>
            <begin position="11"/>
            <end position="86"/>
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    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
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            <end position="856"/>
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    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
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            <end position="884"/>
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    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
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            <end position="923"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="154"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="783"/>
        </location>
    </feature>
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        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
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        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="750"/>
            <end position="762"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="763"/>
            <end position="775"/>
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    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="16"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <location>
            <position position="59"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005498-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1120" mass="120965" checksum="E35D2AE5AE4C6D89" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF19</accession>
    <name>A0A182PF19_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Nucleolar protein 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
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        <text evidence="8">Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
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    <comment type="subunit">
        <text evidence="9">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
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        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
            <location evidence="2 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="3 10">Belongs to the NRAP family.</text>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NOL6/Upt22"/>
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        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
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        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
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        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
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        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="237"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="13">
        <location>
            <begin position="388"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="14">
        <location>
            <begin position="528"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="15">
        <location>
            <begin position="712"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="16">
        <location>
            <begin position="903"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="17">
        <location>
            <begin position="1059"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005524-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1190" mass="136255" checksum="3EBADE61448C6070" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PF89</accession>
    <name>A0A182PF89_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PF89"/>
    <dbReference type="STRING" id="199890.A0A182PF89"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005595-RA">
        <property type="protein sequence ID" value="AEPI005595-PA"/>
        <property type="gene ID" value="AEPI005595"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005595"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048619">
        <property type="term" value="P:embryonic hindgut morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009880">
        <property type="term" value="P:embryonic pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002571">
        <property type="entry name" value="Protein odd-skipped-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000311">
        <property type="entry name" value="protein odd-skipped-related 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF0">
        <property type="entry name" value="PROTEIN BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005595-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="272" mass="28781" checksum="3576E3A94EB6EB79" modified="2016-09-07" version="1">MPTEGPTLDDRGLATLSRSSRIDQFLAGNGGPPTSPTIRGSSGGSGSGSARTPSSSSSGYDSQLAFQHHLMASGGGPPPQHHGRESSAFVPVLPSRALRPGLYPGVLDGPDGLSKEGVPKRGSSYELMAMMADKRKELALREAAAAAMLLPRPGGPPVQSPSGIYPPPGAFLGGPGPSPTSAGTFTFPPAGVGLYPPGVPPGMHAGLDRRLLRAPGRASRPKKQFICKFCNRQFTKSYNLLIHERTHTDERPYSCDICLKAFRRQDHLRDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFW3</accession>
    <name>A0A182PFW3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">NTF2-related export protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PFW3"/>
    <dbReference type="STRING" id="199890.A0A182PFW3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005822-RA">
        <property type="protein sequence ID" value="AEPI005822-PA"/>
        <property type="gene ID" value="AEPI005822"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005822"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000006">
        <property type="entry name" value="NTF2-related export protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="6">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005822-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="136" mass="15869" checksum="CA3C01A090E2D25E" modified="2016-09-07" version="1">MASAGIDQTLREKHSEAFKASHTFIKDYYYHMDKLRHYIARLYTDDAVLIWNGHGVKGKQKIQDLFRHVPFAEHKILSLDAQPYMESSFQSPLSFMVQIAGKVQYKGKPWTAFQQSCMIVADCAKYKIVWDCYRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PFX2</accession>
    <name>A0A182PFX2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4773 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PFX2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI005831-RA">
        <property type="protein sequence ID" value="AEPI005831-PA"/>
        <property type="gene ID" value="AEPI005831"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI005831"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299">
        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF1">
        <property type="entry name" value="DUF4773 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131277" evidence="1">
        <location>
            <begin position="27"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="2">
        <location>
            <begin position="68"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI005831-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="224" mass="25705" checksum="6BDAB1B5975EB5F8" modified="2016-09-07" version="1">MQRYLLFCAVMIGAIGLSSRVWTVASESRRIDFEFYNVRTNRTFKYPTITLYPIGTNRPKFAIRDNRCECESLTCTCCAGVRMERLDFDRVFCTVFTYVPYEFAIDLEVLMDDEPIYRNALSAKNPPPFCLPVPIPYVPLNANLCLKLFDIYTPRQNLHLCLDVEARVWSNPLLILHFECMRMGVDGLVWLKPAEGDGFGPAGAVPEPPIDTYDEVTEERHTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PHZ7</accession>
    <name>A0A182PHZ7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecdysis-triggering hormone</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PHZ7"/>
    <dbReference type="STRING" id="199890.A0A182PHZ7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006558-RA">
        <property type="protein sequence ID" value="AEPI006558-PA"/>
        <property type="gene ID" value="AEPI006558"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006558"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013175910" description="Ecdysis-triggering hormone" evidence="1">
        <location>
            <begin position="16"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006558-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23511" checksum="79F7B7CBA5C18C60" modified="2016-09-07" version="1">MKFVVFFALICYAVGSESPGFFIKLSKSVPRIGRRGDLENFFLKQSKSVPRIGRRAGGFHMAAMAPEESAGSSWFERYMKTSKRPTGGSLAPDDVGKSYKKIRPLDLNHIIDILSDDLFFGSDLKFISWEVLDEALEEDPELLQKLASLARDKEVQQLKKMLGEQGDEMVKYVPLDRNEINAASSRAYMYRLDRTDPNKERIEYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIA9</accession>
    <name>A0A182PIA9_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIA9"/>
    <dbReference type="STRING" id="199890.A0A182PIA9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006671-RA">
        <property type="protein sequence ID" value="AEPI006671-PA"/>
        <property type="gene ID" value="AEPI006671"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006671"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006671-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="553" mass="59806" checksum="B795E0CAC62F85A8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIN7</accession>
    <name>A0A182PIN7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF937 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIN7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006799-RA">
        <property type="protein sequence ID" value="AEPI006799-PA"/>
        <property type="gene ID" value="AEPI006799"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006799"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131438" description="DUF937 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006799-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32302" checksum="23D2927E8D333E48" modified="2016-09-07" version="1">MRYRAWGTLLAGLTGLLLVLDRPDRVAADLMGDIQKGLQTTGKLFGINTIADVADLVAKGFATRRGSQAPAATENVGMVDGLLSQAPSMMTIAMKLLGLDGSQLGAMLVNGIVFLAHIIGTNLGAFRSPTLGDASSPHGPSFSGFTTDPPPLTGESEPSQSAHDHQKPGATPLDWLLRNPSKRFRLLLDQVKHTDLAERLDREMDQLDRYAPEDTDCIRLLMCKVKPFIWKMQHVVRDTVLRPGGTAGQSQDGSKATPSGDEILQGIHANLPSEEEFQRQSKLCEQQFRHCRRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIU7</accession>
    <name>A0A182PIU7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIU7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006860-RA">
        <property type="protein sequence ID" value="AEPI006860-PA"/>
        <property type="gene ID" value="AEPI006860"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006860"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131334" evidence="1">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="2">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006860-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="78" mass="8344" checksum="D486AA86A3BA19FE" modified="2016-09-07" version="1">MKVLVAICCCLLALGLFTVKGADVCRLGERWRCGSKECEKKCETLTSTAPCTAPCTDGCYCEPGFVRSSPGNCSPQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PIZ2</accession>
    <name>A0A182PIZ2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PIZ2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI006905-RA">
        <property type="protein sequence ID" value="AEPI006905-PA"/>
        <property type="gene ID" value="AEPI006905"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI006905"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39948">
        <property type="entry name" value="GEO11419P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39948:SF1">
        <property type="entry name" value="GEO11419P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI006905-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="70" mass="7934" checksum="891525A9F389B6C6" modified="2016-09-07" version="1">MANALNSIIWLLLLIFVSFWLSFFCAGWYVLIYPLTLCIPALSHISDILLSGARFIHICCRGILDGRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJH7</accession>
    <name>A0A182PJH7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PJH7"/>
    <dbReference type="STRING" id="199890.A0A182PJH7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007091-RA">
        <property type="protein sequence ID" value="AEPI007091-PA"/>
        <property type="gene ID" value="AEPI007091"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007091"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF241">
        <property type="entry name" value="CUTICULAR PROTEIN 47EG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131349" evidence="4">
        <location>
            <begin position="17"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007091-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="545" mass="59294" checksum="056ECFE5228D9AA6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJR2</accession>
    <name>A0A182PJR2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6c family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJR2"/>
    <dbReference type="STRING" id="199890.A0A182PJR2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007176-RA">
        <property type="protein sequence ID" value="AEPI007176-PA"/>
        <property type="gene ID" value="AEPI007176"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007176"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd22901">
        <property type="entry name" value="CcO_VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.93.10">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc/VIIs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051389">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034884">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc/VIIs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037169">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02937">
        <property type="entry name" value="COX6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81415">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007176-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="78" mass="8712" checksum="B8AA1C3298B128CB" modified="2016-09-07" version="1">MSEVAARIPKPVLRGLHNATIKRNLIVSGVLCTIAVVALKVLHNDPKKQDYAEFYKTYDANKAFQRMKDAGLLQSVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PJW2</accession>
    <name>A0A182PJW2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PJW2"/>
    <dbReference type="STRING" id="199890.A0A182PJW2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007228-RA">
        <property type="protein sequence ID" value="AEPI007228-PA"/>
        <property type="gene ID" value="AEPI007228"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007228"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF37">
        <property type="entry name" value="ZINC TRANSPORTER FOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131500" description="EF-hand domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="764"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007228-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="833" mass="91434" checksum="EA14EA1586FBC9CE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PK02</accession>
    <name>A0A182PK02_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PK02"/>
    <dbReference type="STRING" id="199890.A0A182PK02"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007268-RA">
        <property type="protein sequence ID" value="AEPI007268-PA"/>
        <property type="gene ID" value="AEPI007268"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007268"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF45">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 12, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007268-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="87" mass="10056" checksum="F4AD0C6811CF130B" modified="2016-09-07" version="1">MANNRECHSQSNSELSPQPPQYVYWQRNDRMINYDDSRRDITIETTPGPRTQSRLIIREPQINDSGNYTCSASNTEPASIYVFVSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKE1</accession>
    <name>A0A182PKE1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the methyltransferase superfamily. METTL16/RlmF family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A182PKE1"/>
    <dbReference type="STRING" id="199890.A0A182PKE1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007408-RA">
        <property type="protein sequence ID" value="AEPI007408-PA"/>
        <property type="gene ID" value="AEPI007408"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007408"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017182">
        <property type="entry name" value="METTL16/PsiM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037350">
        <property type="entry name" value="Mtase_ZK1128_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037350-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007408-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="480" mass="54494" checksum="55352447A50DAF98" modified="2016-09-07" version="1">MAVNDFMHPRNRYRQKPNFRQLVKLYPELNEVASVDISGKVKLDYRNKHAVHLLSKCLLLRDFGLKLELPPNKLVPTLPLRLNYIHWLEDIGAVARWEERKDPVRGIDIGCGASCIYPLLAVVQSNKRWHMVAIEKATDSVESAKANVIRNKLQSYINVKAQKQEGNTILLDVMQQDFPNERFDFCMCNPPFFDSSGKAMQPQDRTGRRREPSNASTGSIEELCTEGGEVTFISQIIDESVQLKDRISVYTTMIGHKKSFDTIQRVLNNASIHNTAGSRFCQGNTTRWAVAWSFDDKVSLSLVPNEQMANCKNVSPGKKKPTGKPFSHRLFELSEVESIKSVQERIVTKLRSIDIDVRTVIASNQAKEMMLELTARENTWSHQRRKRRAGITGTSPQKAEVTIMSSKNGNGTTECQEYNNDRKRPRLEGEKDEECSLTSDRTDDPYIRVALQILQKDDGYHVALQFLAGRAGKDAVNQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKH8</accession>
    <name>A0A182PKH8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PKH8"/>
    <dbReference type="STRING" id="199890.A0A182PKH8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007445-RA">
        <property type="protein sequence ID" value="AEPI007445-PA"/>
        <property type="gene ID" value="AEPI007445"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007445"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131458" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="12"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007445-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="522" mass="55627" checksum="979F726064982BCF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKV9</accession>
    <name>A0A182PKV9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AEPI007576"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DEXXQc_HELZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable helicase with zinc finger domain"/>
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        <property type="entry name" value="Probable helicase with zinc finger domain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="DNA2/NAM7-like"/>
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        <property type="entry name" value="HELZ_DEAD-box_1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="PAM2_motif"/>
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        <property type="entry name" value="SF1_C_Upf1"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
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        </location>
    </feature>
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    </feature>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        <source>
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    <sequence length="2417" mass="260083" checksum="6E97E8FAFBAD8BC7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PKZ3</accession>
    <name>A0A182PKZ3_9DIPT</name>
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        <recommendedName>
            <fullName evidence="10">Endoplasmic reticulum-based factor for assembly of V-ATPase</fullName>
        </recommendedName>
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    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">Epiroticus2</strain>
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                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
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    </reference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ATPase_Vma12"/>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34641" checksum="66B6D43ECEBFB790" modified="2016-09-07" version="1">MSDTLDKLPIVDPTVRIVPSKELSKFIATKLSKVSPSTPVAVRDICATFNPGRRGAKFTNQTGNSSPGKQQNMNIDFTEQERNIISQMIATLNERTQHEPGTLDCGLSSEQEQREDGDSGPTLNLADVKWLYKRLQELRQTDASVPYLHTLLAGCQLRLPQNPIRERNPELEARCQRLRKEQEDREYHRMTKNVDSIRKHMPEETLSYQMKQINRHLIAVAQFLFSVAAGFAFGFIGIELLIGQLDFGFRLLLGIIIALIIALAEIYFLAKKLNEEYELPPPQARIAKETSTMPNGVQLTGKQHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PL81</accession>
    <name>A0A182PL81_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PL81"/>
    <dbReference type="STRING" id="199890.A0A182PL81"/>
    <dbReference type="EnsemblMetazoa" id="AEPI007698-RA">
        <property type="protein sequence ID" value="AEPI007698-PA"/>
        <property type="gene ID" value="AEPI007698"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI007698"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI007698-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="88" mass="9676" checksum="B1FCE7F1689FB73C" modified="2016-09-07" version="1">MGICPGNRLKIIQSHDSGCFTLSPASSPCPTIDSTTNLNSPIPSEIYENTSLCSSTSAGSQRQGKRRSWHIMPNKFCCLNFQANIQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMB8</accession>
    <name>A0A182PMB8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PMB8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008091-RA">
        <property type="protein sequence ID" value="AEPI008091-PA"/>
        <property type="gene ID" value="AEPI008091"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008091"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008091-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="54311" checksum="282A1FBF8FF4FC36" modified="2016-09-07" version="1">MVNLEDGEPDSILSLDVIEIRSLSGEPDYKSVNLTWEVESVHDDDEDRRLPVGYKGRSAKLVSTSTVASRGPRAFNVFYCELQNWGPHRCRSKIVKDESGDSGKSKQYSLLVKNLRMATKYSFHVKPQTKKSDQRASGRADEGEQEEQTGATTGGLNQGQTIIIPTKGFSAHATQCLPHASEIEVETGPYFGGRIAAENGNCGIQGDASSPQESYTMRIDHEQCGSKVSTRDLTVETYITVQENLGILTHSTRRFVVVCTFQPDTLTVRARLALPGKGGAAPVPTSEWWPAQGRNARVRQFNMVDKSGLVLKGSEDERNDIAELPTEQEQDEDTGVPAEVRELPAVEADSQKKVNSAEEPLTDKSKGAASGTKSAGNYARLLNEQQQDEGTGLVDELDEYGQELSENNTDGDGEERVSVVGSKAVNSQRRFSGSMGSSGGGGVGAFDATGLLISACLAVILIGALVYLLQREVKKQRMIHQHQQMERTASERRGAAGGVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PMS9</accession>
    <name>A0A182PMS9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PMS9"/>
    <dbReference type="STRING" id="199890.A0A182PMS9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008253-RA">
        <property type="protein sequence ID" value="AEPI008253-PA"/>
        <property type="gene ID" value="AEPI008253"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008253"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051373">
        <property type="entry name" value="Lin-28_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109">
        <property type="entry name" value="PROTEIN LIN-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109:SF1">
        <property type="entry name" value="PROTEIN LIN-28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="5">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008253-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="185" mass="20334" checksum="808C6E8C88AC5510" modified="2016-09-07" version="1">MERPSGAFQMDEGGGASEQMTEQAHHSTDQEVLVGPRRGRCKWFNVVKGWGFITPDDGGQEVFVHQSVIQMGGFRSLGENEEVEFESKLSAKGYEATSVYGPSHVECKGSDFRPYSKKRRFRKLRCYNCGEFANHIASKCELGPLPKRCHNCRSEDHLIADCPTKPPPTAPAAAATTQSPASPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN02</accession>
    <name>A0A182PN02_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN02"/>
    <dbReference type="STRING" id="199890.A0A182PN02"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008326-RA">
        <property type="protein sequence ID" value="AEPI008326-PA"/>
        <property type="gene ID" value="AEPI008326"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008326"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008326-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="46671" checksum="C8642346959D6A8D" modified="2016-09-07" version="1">MDLTIYNDVPSDTPGTYCRFCFRETSLVPIFHPTTSEPLNMELITVIVDCIGVLLKPELDFPSAACQGCLQLMQEFHHFRRRAREYDKIIRSKILPRIEPEVIIVKEEATDLEHVYDSHEQVDKESSSSSTLTADESRDASIDVLDQLQQLHQQHQFHQQQLLFHQQQQLQQQQQQQLHQQSQQQQQEQSEEQPEPKFSMSAIFSAQANALAAVAAAAAAVTPIRAQTRSQSKRQTTSGSVAPALEDNRCMVCGEKFQSRDVWVAHLAVHTVERPFQCHICLAQFKTKYVQQNHIRTVHENVRSYRCPICTEPSRMFKSKRTLEDHMRYHTGERPFVCCICKITFSSGSVHRNHMYRVHREMRKKDRRCNYCGKVFDRILDLKRHQTSYCEKIVGQVMAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PN57</accession>
    <name>A0A182PN57_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PN57"/>
    <dbReference type="STRING" id="199890.A0A182PN57"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008381-RA">
        <property type="protein sequence ID" value="AEPI008381-PA"/>
        <property type="gene ID" value="AEPI008381"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008381"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000074">
        <property type="entry name" value="dr1-associated corepressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="5">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="5">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008381-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="424" mass="44697" checksum="160ACBDC5325B809" modified="2016-09-07" version="1">MPSKKKKYNARFPAGRIKKIMQTDEEVGKVAQAVPVIIYILFKFNLIWFFEVPRTLELFVESLLTKTLKITNARNAKTLSPSHMKQCIISESRFDFLRDLVKNIPDIGINEDLSGSEAGYGNEGTSPASTSTSSSSVSYSNGGAAAAIASASFVGGHHHHHLAYDAHLPVTLQRSESYSPATASIALHPQHHSSQTSHGKRGLSQGGSLNFYKEIPLEGTESPPPPKLNRLNSAPAGGAPTTLPFKIDILPNLPVGTTGNTTATISSPAVKLGNHQPSSGAITPHITYNFERLGAAAPTTTPSTSLEPVIKLDYSNLRLPATSTSPHGSSTSRSTTVPAVQSLQPTIKIDLSSLATSNTSLTGGDGGTPKKHMEMGGSSKPTTSTATTTNPATVVQSPVAPVAPPLFAPLSSAIPGMDEDYDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PND2</accession>
    <name>A0A182PND2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PND2"/>
    <dbReference type="STRING" id="199890.A0A182PND2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008459-RA">
        <property type="protein sequence ID" value="AEPI008459-PA"/>
        <property type="gene ID" value="AEPI008459"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008459"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008459-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="293" mass="29270" checksum="621BCE373DAB56D8" modified="2016-09-07" version="1">MIGTPRSASLTLNSNTANGSCQAIDNTTFVSGNDHNNNDSSSSSNKGNTDRTGKSQHQAPTYGAIIINNLLLAGPGVATETVEEANYKVDPIAITTRVRSGGGTLLTGSGSTYRTGATEGAAAATLAASRDLRGGSAVGGEAAVGFERVEGFGGGGGEGGGAGGVGVVAGVSRSGTASSGPERHQQPKTASSSGDSGGGGGGGGGGGGRVFNFPGAIASRQGEGVDIVLPVASYVGVPQQQHQSHISHWIESEIIASNSSNSNTMLADKAKQKCTDQLADRREEGVRPERSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNG9</accession>
    <name>A0A182PNG9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the teashirt C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PNG9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008496-RA">
        <property type="protein sequence ID" value="AEPI008496-PA"/>
        <property type="gene ID" value="AEPI008496"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008496"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027008">
        <property type="entry name" value="Teashirt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12487:SF7">
        <property type="entry name" value="PROTEIN TEASHIRT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12487">
        <property type="entry name" value="TEASHIRT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="564"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="98"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="380"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="504"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="717"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="791"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="852"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1061"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1185"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="511"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="853"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="927"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="954"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="993"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1061"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1072"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1191"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1203"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1217"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1236"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008496-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1311" mass="132461" checksum="77E34C95473E0B7A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNJ1</accession>
    <name>A0A182PNJ1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Strictosidine synthase conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNJ1"/>
    <dbReference type="STRING" id="199890.A0A182PNJ1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008518-RA">
        <property type="protein sequence ID" value="AEPI008518-PA"/>
        <property type="gene ID" value="AEPI008518"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008518"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000065">
        <property type="entry name" value="Hemomucin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="6">
        <location>
            <begin position="173"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="425"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008518-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="593" mass="64940" checksum="219DB200E81833B3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PNM4</accession>
    <name>A0A182PNM4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Solute carrier family 25 member 45</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PNM4"/>
    <dbReference type="STRING" id="199890.A0A182PNM4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008551-RA">
        <property type="protein sequence ID" value="AEPI008551-PA"/>
        <property type="gene ID" value="AEPI008551"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008551"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005289">
        <property type="term" value="F:high-affinity L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000120">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF1">
        <property type="entry name" value="SD08189P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="98"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="202"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008551-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35116" checksum="6751C893C6D448B4" modified="2016-09-07" version="1">MNPVLCDFIAGSFGGACGLLVGHPMDTIKAWQQNSNYGMGSAMYNIIIRNNGLRGFYRGMYFPLLSNGALNSVVFAVYGSHLRYLQKHTRSDRLRKKYWRKHVFFAGSMAGLAQVFLACPIEVVKVRLQTLSFIGHPWACLKDIFRREGFSGIYRGITPMMFRDVLPYGVYMYVYEYMLEIEERLHRLSKERLTGVPIGGALQASLIATAGAVAGVASWMFIVPFDVVKTVMQAETDPSVHKSMMHCFRSMIKKHGWRSLFRGSLVIIARAAPVNSATFLGYEYCLEKCHHLLDEKSTHCVYVSLGVEGIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP08</accession>
    <name>A0A182PP08_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLU7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP08"/>
    <dbReference type="STRING" id="199890.A0A182PP08"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008687-RA">
        <property type="protein sequence ID" value="AEPI008687-PA"/>
        <property type="gene ID" value="AEPI008687"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008687"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="10">
        <location>
            <begin position="160"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="433"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008687-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="609" mass="70055" checksum="68A25C9E4568FB90" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PP19</accession>
    <name>A0A182PP19_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 99 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PP19"/>
    <dbReference type="STRING" id="199890.A0A182PP19"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008698-RA">
        <property type="protein sequence ID" value="AEPI008698-PA"/>
        <property type="gene ID" value="AEPI008698"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008698"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11574">
        <property type="entry name" value="GH99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026071">
        <property type="entry name" value="Glyco_Hydrolase_99"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572">
        <property type="entry name" value="ENDO-ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572:SF4">
        <property type="entry name" value="RE57134P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16317">
        <property type="entry name" value="Glyco_hydro_99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="MADF" evidence="10">
        <location>
            <begin position="434"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008698-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="684" mass="79017" checksum="A551520C53B5C161" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PPB4</accession>
    <name>A0A182PPB4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PPB4"/>
    <dbReference type="STRING" id="199890.A0A182PPB4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI008793-RA">
        <property type="protein sequence ID" value="AEPI008793-PA"/>
        <property type="gene ID" value="AEPI008793"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI008793"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09515">
        <property type="entry name" value="SAM_SGMS1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000116">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="11">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI008793-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="633" mass="70673" checksum="8426E7B51EFD0B44" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQ99</accession>
    <name>A0A182PQ99_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
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                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQE5</accession>
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            <taxon>Insecta</taxon>
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    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">Epiroticus2</strain>
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    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A182PQE5"/>
    <dbReference type="STRING" id="199890.A0A182PQE5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009175-RA">
        <property type="protein sequence ID" value="AEPI009175-PA"/>
        <property type="gene ID" value="AEPI009175"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009175"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02992">
        <property type="entry name" value="PDI_a_QSOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1960:FF:000001">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000001">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000073">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1960">
        <property type="entry name" value="QSOX sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040986">
        <property type="entry name" value="QSOX_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042568">
        <property type="entry name" value="QSOX_FAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF8">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18371">
        <property type="entry name" value="FAD_SOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131653" description="Sulfhydryl oxidase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="71"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="12">
        <location>
            <begin position="456"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009175-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="692" mass="78217" checksum="7D74C34CFCA86A64" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQU7</accession>
    <name>A0A182PQU7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-terminal acetyltransferase B complex subunit MDM20 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQU7"/>
    <dbReference type="STRING" id="199890.A0A182PQU7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009328-RA">
        <property type="protein sequence ID" value="AEPI009328-PA"/>
        <property type="gene ID" value="AEPI009328"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009328"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="832"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="850"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009328-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="953" mass="109077" checksum="072A7A6995991F12" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQV4</accession>
    <name>A0A182PQV4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQV4"/>
    <dbReference type="STRING" id="199890.A0A182PQV4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009335-RA">
        <property type="protein sequence ID" value="AEPI009335-PA"/>
        <property type="gene ID" value="AEPI009335"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009335"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000378">
        <property type="entry name" value="Notochord homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF67">
        <property type="entry name" value="GNOT1 HOMEODOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="405"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="407"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009335-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="540" mass="58048" checksum="DC276184643DA506" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PQX1</accession>
    <name>A0A182PQX1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ornithine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PQX1"/>
    <dbReference type="STRING" id="199890.A0A182PQX1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009352-RA">
        <property type="protein sequence ID" value="AEPI009352-PA"/>
        <property type="gene ID" value="AEPI009352"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009352"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000020">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="10">
        <location>
            <begin position="43"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009352-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="47747" checksum="112DC78C7D60F3D1" modified="2016-09-07" version="1">MKFLENESDKIEIVDGPVEVPAIIDTLVDQLPTDNPFYVMDIGDIVRKHQQWIEKMPRVVPHYAVKCNDTDLVCATLAALGASFDCASKGEIAKVLSLGVAPERIIFANPMKPASHLRYASSNAVKTMTYDSDTELHKIKQYCPDAKLVIRIRCEAEKAQCPLGKKFGCDPVEEAPRLIKIARSLGLEVVGVSFHVGSGCADFPIYYKAISYARDLFDYAAQLGYSFNLLDIGGGFPGDTGTSIDEVAMIVNTALDTFFPDKSVRVISEPGRYYVSSAFTLVTNVQSKRICLNAKTGTIERMMYYLNDGVYASFNSILYDHQVPHPKLIGGQSGKQYKSTIWGPTCDALDQLIETIALPELQIDDWVVFENMGAYTIPVASPFNGFELPKIYCYISKKHWEMLETLFPLQNECSLIAANTLPSSYETVACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS04</accession>
    <name>A0A182PS04_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Collagenase NC10/endostatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PS04"/>
    <dbReference type="STRING" id="199890.A0A182PS04"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009739-RA">
        <property type="protein sequence ID" value="AEPI009739-PA"/>
        <property type="gene ID" value="AEPI009739"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009739"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010515">
        <property type="entry name" value="Collagenase_NC10/endostatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06482">
        <property type="entry name" value="Endostatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Collagenase NC10/endostatin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009739-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="166" mass="18887" checksum="FEEEA29DAE7333CC" modified="2016-09-07" version="1">MGEQARAPERIQNLDSIVRLADRELPVVNTRGDVLFNSWNGIFNGQGGFFSQAPRIYSFSGKNVLTDMAWPQKLVWHGSSAHGERAIDTYCDAWHTSMPDKVGLASSLLGNKLLDQERYSCDNRFVVLCVEAVPQDRRRKRRDTSSQREFANEKEYSQYLQSIGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PS59</accession>
    <name>A0A182PS59_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PS59"/>
    <dbReference type="STRING" id="199890.A0A182PS59"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009794-RA">
        <property type="protein sequence ID" value="AEPI009794-PA"/>
        <property type="gene ID" value="AEPI009794"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009794"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12336">
        <property type="entry name" value="RRM_RBM7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052285">
        <property type="entry name" value="NEXT_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13798">
        <property type="entry name" value="RNA BINDING MOTIF RBM PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13798:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009794-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="252" mass="29097" checksum="A1E8D3D765B3F147" modified="2016-09-07" version="1">MSEDDRILWCGNLSENVTEDMLYELFLQAGPLENVKIPRDGDRRQRNYAFITFVHACSVEYAINIFDGTVLFQRPLTLHRKNRNGPNPAASPQVNFNYPVGGSTNSSSSNHLRVSSDDFPQPVQQSQAVDDNAFLSVNNFMDQFPGLYSAFANPQNMRLTPEMIAQLGQQMLGADLPPLGDEQSSLQTKLHRNERSHYHDRHNKKPYSREDRYGHKNNRSESNSSSRHSKYDNVNRRNSNEHDHHRNNRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSD2</accession>
    <name>A0A182PSD2_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSD2"/>
    <dbReference type="STRING" id="199890.A0A182PSD2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009867-RA">
        <property type="protein sequence ID" value="AEPI009867-PA"/>
        <property type="gene ID" value="AEPI009867"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009867"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02122">
        <property type="entry name" value="PA_GRAIL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16668">
        <property type="entry name" value="RING-H2_RNF130-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000009">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF23">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131740" description="RING-type domain-containing protein" evidence="11">
        <location>
            <begin position="27"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009867-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="512" mass="55861" checksum="063641EF94EB7082" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSG4</accession>
    <name>A0A182PSG4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Bleomycin hydrolase</fullName>
            <ecNumber evidence="3 9">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="3 9"/>
    <dbReference type="AlphaFoldDB" id="A0A182PSG4"/>
    <dbReference type="STRING" id="199890.A0A182PSG4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009899-RA">
        <property type="protein sequence ID" value="AEPI009899-PA"/>
        <property type="gene ID" value="AEPI009899"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009899"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000021">
        <property type="entry name" value="Bleomycin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009899-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="455" mass="52396" checksum="C24E8EC68EBE84C2" modified="2016-09-07" version="1">MLPSPLNEEFFQKCRTDFYDCPKNVLAQNVCTRIDPFDACLSRKSLENTQHVFTYKIENEGKPLTNQKSSGRCWLFAALNCIRIPFIKQYNLDEFEFSQAYLFYWDKIERANYFLNNVVDTAKRGEAVDGRLVSFLLSDPTCDGGQWDMLVNLINKHGLMPKKCFPESYSCEASTRMNSVVKSKLREYAKDLRKLIDNGASDDEVKERMKKQMNEVYNIVGICLGIPPEKFTWEYYDKSKKYLNIGPIRPIDFYEKYVKPYFNVDDKVCLVTDPRSSNLYGRSYTVDCLGNVVGGRPVLYNNQPVELLLDLVTKALKFGEPVWFGCEVNKRFAGKQGIEDLDIHDFKLVFGVDIQTTMDKADRLLYGESMMTHAMVFTGVSVDPNSQKPTKFRVENSWGEDRGEKGYLIMTAEWFKEFVFEVVVDRSIVSQDVLDVFDLPPIVLPAWDPMGTLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSI7</accession>
    <name>A0A182PSI7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4789 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PSI7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009922-RA">
        <property type="protein sequence ID" value="AEPI009922-PA"/>
        <property type="gene ID" value="AEPI009922"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009922"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031993">
        <property type="entry name" value="DUF4789"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21177:SF4">
        <property type="entry name" value="IP06524P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21177">
        <property type="entry name" value="IP06524P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16033">
        <property type="entry name" value="DUF4789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131818" evidence="1">
        <location>
            <begin position="26"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4789" evidence="2">
        <location>
            <begin position="55"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009922-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="220" mass="24317" checksum="8FDB02081170C34A" modified="2016-09-07" version="1">MANSFALVPLVCAAVVAVLPGLSRAQELFAFPADVVVNPYLENARNRTPVFIPGKCGTNEILYPGDHDNDWVCDCRPGHVYSPPQDSCYPLFQQGFCQSGEYVDLARPSKIVKCTRNVCTGKNEVPYKGRCVQLHRNNRLCKIERRISWVIGVNITTLELDCVEGTTEMLEVTVNNRNMGDDEEVEGDKTGSMKTTPVIFFQGAKLCSDGTKTKYNGLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PSJ4</accession>
    <name>A0A182PSJ4_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PSJ4"/>
    <dbReference type="STRING" id="199890.A0A182PSJ4"/>
    <dbReference type="EnsemblMetazoa" id="AEPI009929-RA">
        <property type="protein sequence ID" value="AEPI009929-PA"/>
        <property type="gene ID" value="AEPI009929"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI009929"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI009929-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="217" mass="24730" checksum="8A467EF1ECC4BD0E" modified="2016-09-07" version="1">MSAVKIFSLAKQSSRLIRPSSISATARYYSSQPKPAAIKPEEYYYVNNKEKSMDMDDITDRAAQTIFWTELFRGAAVTLAHIFKEPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEERADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLSNGDKWESEIATNINADYLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PT65</accession>
    <name>A0A182PT65_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PT65"/>
    <dbReference type="STRING" id="199890.A0A182PT65"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010151-RA">
        <property type="protein sequence ID" value="AEPI010151-PA"/>
        <property type="gene ID" value="AEPI010151"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010151"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000180">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily C, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131862" description="J domain-containing protein" evidence="13">
        <location>
            <begin position="35"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="14">
        <location>
            <begin position="54"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="16">
        <location>
            <begin position="407"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="15">
        <location>
            <begin position="410"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="466"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="230"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010151-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="62635" checksum="13A4A0FF6217FD13" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PTY0</accession>
    <name>A0A182PTY0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Peroxidasin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[collagen] + L-methionyl-[collagen] + H2O2 = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66020"/>
            <dbReference type="Rhea" id="RHEA-COMP:12751"/>
            <dbReference type="Rhea" id="RHEA-COMP:16949"/>
            <dbReference type="Rhea" id="RHEA-COMP:16951"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:166867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-[collagen] + L-methionyl-[collagen] + hypobromite = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66024"/>
            <dbReference type="Rhea" id="RHEA-COMP:12751"/>
            <dbReference type="Rhea" id="RHEA-COMP:16949"/>
            <dbReference type="Rhea" id="RHEA-COMP:16951"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29250"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:166867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-tyrosyl-[protein] + bromide + H2O2 + H(+) = 3-bromo-L-tyrosyl-[protein] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:69360"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:17686"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:183512"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:69361"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>bromide + H2O2 = hypobromite + H2O</text>
            <dbReference type="Rhea" id="RHEA:66016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29250"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hypobromite + L-tyrosyl-[protein] + H(+) = 3-bromo-L-tyrosyl-[protein] + H2O</text>
            <dbReference type="Rhea" id="RHEA:69356"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:17686"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29250"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:183512"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:69357"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the peroxidase family. XPO subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PTY0"/>
    <dbReference type="STRING" id="199890.A0A182PTY0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010416-RA">
        <property type="protein sequence ID" value="AEPI010416-PA"/>
        <property type="gene ID" value="AEPI010416"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010416"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09826">
        <property type="entry name" value="peroxidasin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001851">
        <property type="entry name" value="Peroxidasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000001">
        <property type="entry name" value="Peroxidasin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000248">
        <property type="entry name" value="peroxidasin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034824">
        <property type="entry name" value="Peroxidasin_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF58">
        <property type="entry name" value="PEROXIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 19" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 19" id="KW-0408">Iron</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="95"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="22">
        <location>
            <begin position="1021"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="902"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="965"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="917"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010416-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="26">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1098" mass="123897" checksum="25FD66519D998705" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUC9</accession>
    <name>A0A182PUC9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUC9"/>
    <dbReference type="STRING" id="199890.A0A182PUC9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010565-RA">
        <property type="protein sequence ID" value="AEPI010565-PA"/>
        <property type="gene ID" value="AEPI010565"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010565"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010565-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="167" mass="19200" checksum="FE91582187942351" modified="2016-09-07" version="1">MRASLSTSSIAFKDPKSQKEAPILDASVILAGEEERAREHLPTITVPTKVDLSPITGVPEEHVKERRVRIFIPAKNAMQSGTDNIHHWSIEFDNRERWENPLMGWSSTGDPLSNMRVDFTTADEAIAHCEKNGWRWFVDKPEIQKKQRVKNYGINFSWNKRTRVSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUP8</accession>
    <name>A0A182PUP8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PUP8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010685-RA">
        <property type="protein sequence ID" value="AEPI010685-PA"/>
        <property type="gene ID" value="AEPI010685"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010685"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008131834" evidence="2">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010685-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="203" mass="21460" checksum="6AFB7D6443EDF74A" modified="2016-09-07" version="1">MKTFVILVLCAAIALAAAEDKKGPATHHDVKQHESHGPQLKQQQPHDQHQQRQHPATQQHSLKQNQQQHQPQPAPYKHKREAPKNPAAGHSTTAAPKATIDPKQPSILPAIIGQAPKNKRDTVAAQPAAATRPSTSAPSKASASGASTNGQQRKTQSAPRPTTAKLNRDQASNTPQSAGNSKVPATVNQPASNPTTASPAKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PUW1</accession>
    <name>A0A182PUW1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182PUW1"/>
    <dbReference type="STRING" id="199890.A0A182PUW1"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010748-RA">
        <property type="protein sequence ID" value="AEPI010748-PA"/>
        <property type="gene ID" value="AEPI010748"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010748"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17335">
        <property type="entry name" value="MFS_MFSD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="41"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="780"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="906"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="694"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="906"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="930"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010748-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="949" mass="104939" checksum="D8FDEFDBA9AF4079" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PV08</accession>
    <name>A0A182PV08_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAP kinase-activating death domain protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MADD family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182PV08"/>
    <dbReference type="EnsemblMetazoa" id="AEPI010795-RA">
        <property type="protein sequence ID" value="AEPI010795-PA"/>
        <property type="gene ID" value="AEPI010795"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI010795"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
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    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
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        <location>
            <begin position="34"/>
            <end position="669"/>
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            <begin position="132"/>
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        </source>
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        </source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI010795-PA"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1756" mass="193373" checksum="C09B1159BFAFBF3F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PVV1</accession>
    <name>A0A182PVV1_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S10"/>
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        <property type="entry name" value="Ser_caboxypep_his_AS"/>
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        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
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    </dbReference>
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        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007951010" description="Carboxypeptidase" evidence="7">
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011088-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="483" mass="54462" checksum="BF0D8E255D5E0A1D" modified="2016-09-07" version="1">MTQYGQLFLLLGLLLASTNGLFINPYEKLWPRGGSLSSAAPTKGDNGEPLLLTPYIEKGNIAEGQKAARVEHSRIRGFESYAGFLTVDKRFNSNLYFWYFPAKVNRTTAPLLLWLQGGPGASSLFGLFEENGPFRITRELVAMEREHSWYENHNLLYIDNPVGTGFSFTDSDAGYARNQVQIGEELHSAVVQFLKLFPELQSLPFYITGESYAGKYVPALGYTIHKKNGNPQNPWINLAGMAIGNGYSDPVNQLNYGEYLYQLGLIDSNALERFEQDEQSVATCIAKGNYRCAFEIMDDLLDGDANGGGSFFRNVSGFETYYNYLNTAEDPLDAVWLVAFLNLDETRRALHVGDQPFHDLDADNKVERFLEEDVFESVAPWIAELLQHYRIMFYNGQLDIICAYPMMVNYLQTLQFDGANYYRSVPRGKLEFDGEIAAYFKLAYGLVEVLVRDAGHMVPRDQPKWAHRLITAFTHPGSVAGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182PWU0</accession>
    <name>A0A182PWU0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="1">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182PWU0"/>
    <dbReference type="STRING" id="199890.A0A182PWU0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI011427-RA">
        <property type="protein sequence ID" value="AEPI011427-PA"/>
        <property type="gene ID" value="AEPI011427"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI011427"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI011427-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37794" checksum="A62D30F04E223C63" modified="2016-09-07" version="1">MDGNDFCADYHGECSTLLKNEEAEYLEDGEEWEIVSEASVLNEDSEKDEFTDVEYLEAEESETSNVSELAKSLRIWFIKNKIVRNSANDFLLILRAEASCTLPKDVRTLLKAPVRVGEQIVAVTGGGHMWYHDIESSLVHYFRDVTPDVQSFELNLSVDGIPMYNRSSMQMWPILMQLHGIPNVPVMVVAIYSGYSKPGDAECILRPLVTELNKLYEKGLSINDKLYSVSLRAIIADSPARAFIKQVCYFNGVHGCLKCKCLGIILNKPRKVFFEDTCAANRTDEEFRKEPFSDKGHRKGQTPLTDIIGFNMIHGVPLGDKFHLIDLGVMKKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A240PPW7</accession>
    <name>A0A240PPW7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A240PPW7"/>
    <dbReference type="STRING" id="199890.A0A240PPW7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015394-RA">
        <property type="protein sequence ID" value="AEPI015394-PA"/>
        <property type="gene ID" value="AEPI015394"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015394"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012196140" description="Phenoloxidase-activating factor 2" evidence="7">
        <location>
            <begin position="22"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="161"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015394-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="426" mass="46426" checksum="BB44EFA80F363040" modified="2017-10-25" version="1">MLSRTIAVVAAVALMAGLVASQDTLDDLYLSLYNLTENKNTVTEPPAAVAPAAALPAAAVPQAPAPAEQRYTCTGECVQYYLCSDNKIITDGAGIIDIRVGEDPTEEYECPHFLNTCCEKDAVLDVPPPSVTKAPPTTDNQQEPRRPTCGFRNVDGLGFRITGNKNGESEYGEFPWMLAVLREERVADSNLNVYECGASLIAPNVVLTAAHCVFNKQKEQLLIRAGEWDTQTRDELYQHQDRRVAEVITHEAFNKGSLANDVALLILTEPFQLAENVQPICLPPKGTSFDRSKCFASGWGKNVFGKEGKYQVILKKVELPVVPQADCQQSLRTTRLGRRFVLHPSFLCAGGVAGQDTCRGDGGSPLVCPVPGSPTHYYQAGIVAWGIGCGENGIPGVYGNVAFFRDWIDQQLVQRSILARDYVYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3F2YWM6</accession>
    <name>A0A3F2YWM6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A3F2YWM6"/>
    <dbReference type="STRING" id="199890.A0A3F2YWM6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI015467-RA">
        <property type="protein sequence ID" value="AEPI015467-PA"/>
        <property type="gene ID" value="AEPI015467"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI015467"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="5"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI015467-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="546" mass="60701" checksum="A004CF0D0AB5456D" modified="2019-01-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182NZK8</accession>
    <name>A0A182NZK8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">60S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182NZK8"/>
    <dbReference type="STRING" id="199890.A0A182NZK8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000089-RA">
        <property type="protein sequence ID" value="AEPI000089-PA"/>
        <property type="gene ID" value="AEPI000089"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000089"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000004">
        <property type="entry name" value="60S ribosomal protein L11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="12">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="13">
        <location>
            <begin position="77"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000089-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21698" checksum="1C43CB781261049A" modified="2016-09-07" version="1">MAAKDDKATKPAAGKDKSKNIMRDLRIRKLCLNICVGESGDRLTRAAKVLEQLTNQTPVYSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILERGLKVREYELRRDNFSQTGNFGFGIQEHIDLGIKYDPTIGIYGLDFYVVLGRPGYNVAQRRRKTGKIGFIHRLTKEDAMKWFQQKYDGVILNSKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P050</accession>
    <name>A0A182P050_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P050"/>
    <dbReference type="STRING" id="199890.A0A182P050"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000282-RA">
        <property type="protein sequence ID" value="AEPI000282-PA"/>
        <property type="gene ID" value="AEPI000282"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000282"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026321">
        <property type="entry name" value="CC134"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14735">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14735:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15002">
        <property type="entry name" value="ERK-JNK_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000282-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="424" mass="47422" checksum="7A314CEBA84D8209" modified="2016-09-07" version="1">MHRVKDACGLSDVAHIESLQEKSQCALEEYCRSQYVSLSAVIDRTFGSLVTTSSLMFRIILQVIEQLFFVRLAGVSESGSDSATVEGNEPTGSDVNSFDSTLAALAAAGGGDHTASDPRKMLRSQATDLPTILMARGSASHVAGLHLIDEIDRRAGDSDSANGQQQLRQQDDTNVSVVDEDAVRMFTKVYSMSDCLFILFLTLTFAGFSGLEKSTFPYLVDAKDAEQVPLLDLGKMINENVYSKIFVRKREEHKLLVNHLRSIEDYGKRYKLMKIGIDEIIRIIREEGGKLRGNKITAESEFPKQQELINALAQFLENSCLFGELVLHFPDMSYRILKSVSDWRTLMTDALNYTKTFVQILDEKSIELLNLLNQEINEDQRTPEYVNPYREGTQPVDSETTKSKKKIKTKPKKGPSLSPAKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P0U9</accession>
    <name>A0A182P0U9_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P0U9"/>
    <dbReference type="STRING" id="199890.A0A182P0U9"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000531-RA">
        <property type="protein sequence ID" value="AEPI000531-PA"/>
        <property type="gene ID" value="AEPI000531"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000531"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="11">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000531-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="100" mass="10738" checksum="1369945B22434BA7" modified="2016-09-07" version="1">MFPVGRIHRHLKNRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P110</accession>
    <name>A0A182P110_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P110"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000592-RA">
        <property type="protein sequence ID" value="AEPI000592-PA"/>
        <property type="gene ID" value="AEPI000592"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000592"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000592-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="346" mass="38267" checksum="72BAD679744EE265" modified="2016-09-07" version="1">MANVHHHHHHYSNHRHRPFCGVDRQLKKIEEMFNQNQKENEVKIIESHTSRKCSVHGTHRRGSVCSVKRRDSIASSVGDLSTVGGVGKQQQQLHRPSYGSIYNVGREAEMAARRRSRLGNRNSIANLGDLPQHYVIAPSPAGRKSLSGFADPRRRDSMPVLNTIKPLSNRPLEHPADFPSMLRATSVSTVDLRRKPSIGGGGTGVTRRSSMSSKRNSLQLDDSLATMKLHSILKKAASPSKDSEDSGEHELCDMTKRLSFSQNGHQRRNSNDSSYSSFSRRISIDSLDASRRYSRRLSDASSLFGGEEDASSGSGGTNDIDRIKVLNSSFANSFDDAVGGDREVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P175</accession>
    <name>A0A182P175_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Endomembrane system</location>
            <topology evidence="14">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P175"/>
    <dbReference type="STRING" id="199890.A0A182P175"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000657-RA">
        <property type="protein sequence ID" value="AEPI000657-PA"/>
        <property type="gene ID" value="AEPI000657"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000657"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000003">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000029">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000202">
        <property type="entry name" value="ras-related protein Rab-8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0636">Prenylation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="15">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="16">
        <location>
            <begin position="222"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000657-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="59656" checksum="1764EECE144A5FD4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P180</accession>
    <name>A0A182P180_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P180"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000662-RA">
        <property type="protein sequence ID" value="AEPI000662-PA"/>
        <property type="gene ID" value="AEPI000662"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000662"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000662-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="142" mass="14977" checksum="E55434B62C2931E9" modified="2016-09-07" version="1">MGKMRPGSDRTRAPLTCGCKHVLLLVSLNCLVQVLLLASSASATSMYYKKVGGEKYEPDWVPVSSTVIPLVERVVGVGARTNPSSTGGSGQPGPVERLQSADESYKRAYVKHISKFTKIGTAGALVQPGTLITGKMAAKAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1H3</accession>
    <name>A0A182P1H3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase III subunit RPC8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA-directed RNA polymerase III subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">DNA-directed RNA polymerase III subunit rpc8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Interacts with CRCP/RPC9. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1H3"/>
    <dbReference type="STRING" id="199890.A0A182P1H3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000755-RA">
        <property type="protein sequence ID" value="AEPI000755-PA"/>
        <property type="gene ID" value="AEPI000755"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000755"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000130">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="15">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="16">
        <location>
            <begin position="83"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="157"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000755-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="243" mass="26702" checksum="9919CA89D1D711BD" modified="2016-09-07" version="1">MFVLAELKDNVRIAPELFGLKLPEAIKDEINRKLANKVLLNVGLCIALKDIVKLGDSIILPGDGASHTEVNFRYIVFRPIIGDVITGKIRSCSREGVHITLGFFDDILIPPSALQHPSRYEEAEQAWVWEYPLEDGNTHDLYMDIGESIKFRVSGEVFEESSPIGPPDQEVPSTSAGTSASGGAGTSGQDSNKTPYRIVAAINESGLGLLSWWVQQNQEEDDEGGEEEEQEEEQEQDSGGENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1N7</accession>
    <name>A0A182P1N7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NFU1 iron-sulfur cluster scaffold homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P1N7"/>
    <dbReference type="STRING" id="199890.A0A182P1N7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000819-RA">
        <property type="protein sequence ID" value="AEPI000819-PA"/>
        <property type="gene ID" value="AEPI000819"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000819"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000002">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="10">
        <location>
            <begin position="68"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000819-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="280" mass="31186" checksum="63402E1816DB003E" modified="2016-09-07" version="1">MLQNTRKFVWNLRALAAASCGRVGTSNATSTTAPFSTLTHSDRKRTFQPNRTVGRTGPALLFRRTMFIQTQDTPNPDSLKFLPGCAVLEKGQTMDFPSVSSAQCSPLAKLLFRVEGVRSVFFGGDFVTISKQEDAEWRIIKPEVFAVIMDFFASGLPVVTDAKPNPDTQFNEDDDETVQMIKELLDTRIRPTVQEDGGDIIFMGFDDGVVKLKMQGSCSSCPSSIVTLKNGVQNMLQFYIPEVVSVEQVTDEVDKIAEQEFSRLEKQIRQKDEPPAENKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P1W7</accession>
    <name>A0A182P1W7_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P1W7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000901-RA">
        <property type="protein sequence ID" value="AEPI000901-PA"/>
        <property type="gene ID" value="AEPI000901"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000901"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000901-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="93" mass="10635" checksum="599B35CBA88F3D28" modified="2016-09-07" version="1">MQLLQRKKTDPSFVISIESGVEEVREAKVHEECDFLVDVLTGKRSVSPDFCCKMLYMIFCTCFTNESNQRKVTRGQAPPQSSNAQRPLTYQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P259</accession>
    <name>A0A182P259_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P259"/>
    <dbReference type="EnsemblMetazoa" id="AEPI000993-RA">
        <property type="protein sequence ID" value="AEPI000993-PA"/>
        <property type="gene ID" value="AEPI000993"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI000993"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000471">
        <property type="entry name" value="E-cadherin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF133">
        <property type="entry name" value="CADHERIN-RELATED FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130720" description="Cadherin domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1564"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="264"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="369"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="489"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="611"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="757"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="869"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="975"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1126"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1245"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1341"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1693"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1711"/>
            <end position="1724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI000993-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1724" mass="194969" checksum="D5A9153BCFF8C207" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2M3</accession>
    <name>A0A182P2M3_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P2M3"/>
    <dbReference type="STRING" id="199890.A0A182P2M3"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001157-RA">
        <property type="protein sequence ID" value="AEPI001157-PA"/>
        <property type="gene ID" value="AEPI001157"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001157"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23293">
        <property type="entry name" value="beta-trefoil_MIR_SDF2_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000023">
        <property type="entry name" value="Stromal cell-derived factor 2-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="133"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001157-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="205" mass="22491" checksum="6F2BF2AF687B673B" modified="2016-09-07" version="1">IASTIDHIAAARNNRHVTCGTVLKLLNTDYKVRLHSHDVKYGTGSGQQSVTATELQEDVNSHWAVKAATGKHCERGEPVKCGDTIRLHHLATNKNLHSHHFQSPLSGNQEISAYGDEHGEGDTGDHWLVICSGDSWVRSNAVRLQHIDTDMYLGVSGRTFGRPINGQMEVVGLPNPYSGTEWIAAEGLFIHPTEKDSGSRIHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2N5</accession>
    <name>A0A182P2N5_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DMAP1-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DIP2 family.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P2N5"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001169-RA">
        <property type="protein sequence ID" value="AEPI001169-PA"/>
        <property type="gene ID" value="AEPI001169"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001169"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000001">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="616"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="1301"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="1821"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1765"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1783"/>
            <end position="1797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001169-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1932" mass="208544" checksum="EADAD726566C063E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2T2</accession>
    <name>A0A182P2T2_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2T2"/>
    <dbReference type="STRING" id="199890.A0A182P2T2"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001218-RA">
        <property type="protein sequence ID" value="AEPI001218-PA"/>
        <property type="gene ID" value="AEPI001218"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001218"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF38">
        <property type="entry name" value="HL01515P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
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        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001218-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="156" mass="17714" checksum="691769FC18B3A39B" modified="2016-09-07" version="1">MYDVVALFRINIEASLMDPLVQVNGIRIIFDFDGLSMSHVAQASPKHAMVSLQWIQKCCPLQLKSIHIVNNSMLFNVLFTIFKPFISKELRDKMHFHNRDYSGLTKCISAKCLPPAYGGTLDAPECEGQLLGDFMQLYDKHYEAMDAFGYEESNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2X0</accession>
    <name>A0A182P2X0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2X0"/>
    <dbReference type="STRING" id="199890.A0A182P2X0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001256-RA">
        <property type="protein sequence ID" value="AEPI001256-PA"/>
        <property type="gene ID" value="AEPI001256"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001256"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12725">
        <property type="entry name" value="RRM2_CPEB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000054">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.40:FF:000002">
        <property type="entry name" value="Putative Cytoplasmic polyadenylation element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF9">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="699"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="885"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="483"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="315"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="484"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="599"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1027"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1093"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1106"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1148"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001256-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1257" mass="131523" checksum="9EA3C1D328E260B4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P2Z8</accession>
    <name>A0A182P2Z8_9DIPT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A182P2Z8"/>
    <dbReference type="STRING" id="199890.A0A182P2Z8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001286-RA">
        <property type="protein sequence ID" value="AEPI001286-PA"/>
        <property type="gene ID" value="AEPI001286"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001286"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001286-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="195" mass="21591" checksum="94DF02B469063BEA" modified="2016-09-07" version="1">MTITGPSKGGSGGGMRPLKVTTVGDGMVGKTCMLITYTQNEFPSEYVPTVFDNHACNIVVDGSDYALTLWDTAGQEDYERLRPLSYPNTDCFLICYSISNRTSFDNVLSKWYPEIRHFAPSVPIVLVGTKSDLRVPGSEKFVTTAEGKKLKHKIKAYAMVECSAKRKLNLAEVFDEAVRAVEKKPHATPRMCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P312</accession>
    <name>A0A182P312_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CHHC U11-48K-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P312"/>
    <dbReference type="STRING" id="199890.A0A182P312"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001300-RA">
        <property type="protein sequence ID" value="AEPI001300-PA"/>
        <property type="gene ID" value="AEPI001300"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001300"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21268">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21268:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10200">
        <property type="entry name" value="Ndufs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="17">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="CHHC U11-48K-type" evidence="17">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001300-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="318" mass="35988" checksum="E50651CBE3FB80A8" modified="2016-09-07" version="1">MSQMRQCPFEPTHLIEGKKFTSHLVKCQRQHPDIKLAKCNYDTSHLMREEELKEHLKTCSARGELDVYKYTLSTAAAANVSSAPDPAENLIINTDGPTARRGEGNSLMDDTECWDDSAFKPYDPLESCRIKREENSRFIVPKLNQFAEQSTAAAVLRNDIAQKSGGDDGRKVKQEPSSDEEFGSSALNERQNDLEQFGLRRNASHGGGNDKRLIQQKMSLGPFFRSPFTDLTASMVNFQQYDKCGELEMASIDCLEAYGTVRGAKKCADLLADFQECAFMTKQIARFRAMRMERHRQGWNGERKGDEYYAPPPRVDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P386</accession>
    <name>A0A182P386_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">Epiroticus2</strain>
        </source>
    </reference>
    <dbReference type="STRING" id="199890.A0A182P386"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001370-RA">
        <property type="protein sequence ID" value="AEPI001370-PA"/>
        <property type="gene ID" value="AEPI001370"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001370"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1455"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1518"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1551"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1584"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001370-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1712" mass="195990" checksum="A4CC94A10C746803" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P3X6</accession>
    <name>A0A182P3X6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A182P3X6"/>
    <dbReference type="STRING" id="199890.A0A182P3X6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001612-RA">
        <property type="protein sequence ID" value="AEPI001612-PA"/>
        <property type="gene ID" value="AEPI001612"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001612"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130780" description="dolichol kinase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001612-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="460" mass="50732" checksum="DA432495886A0864" modified="2016-09-07" version="1">PGASHGWWLCLLVPACYAATVWRPYQNDHHQNLPRDYKRTAIVTFGLLLQSLVIRGSLESRWNRRQGLLLTLVVGALSWGLLMVCLKENVVFAGISGVLSVLLYNQLYYTVLRTIPKSFSYGEAFIVVQGFVAFSYSLLLQLPPALFRADGAYTEMQTIYYILQIGLMGILFLVWATYSITWLRKTVPFWIALVATTAMVALCPIGKLPAITRLVLFLWADMQTMITTGMYLALLILTVSFVMWQFNYGRRTTTATRKVFHFLIVLVYGPGLWYQCRLLYLASGLMLAVLIVLETARLIQLAPVSNVLNTAVNLFIDEKDAGAIALTPIYLLVGCSLPLWLHPAPCDLTNSGGLQMLTLLAGVLSIGIGDTAASVAGYHFGRHKWHAYTNKSVEGTVASVLLQALVIGALYHVGVIHLTVGRAAYAGIAVIVNALVESRTDQIDNLVLPLVTYLILVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4A0</accession>
    <name>A0A182P4A0_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein smoothened</fullName>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4A0"/>
    <dbReference type="STRING" id="199890.A0A182P4A0"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001736-RA">
        <property type="protein sequence ID" value="AEPI001736-PA"/>
        <property type="gene ID" value="AEPI001736"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001736"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071679">
        <property type="term" value="P:commissural neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15030">
        <property type="entry name" value="7tmF_SMO_homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000068">
        <property type="entry name" value="Smoothened, frizzled class receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035683">
        <property type="entry name" value="SMO_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF35">
        <property type="entry name" value="PROTEIN SMOOTHENED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008130806" description="Protein smoothened" evidence="20">
        <location>
            <begin position="23"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="21">
        <location>
            <begin position="75"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="22">
        <location>
            <begin position="246"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="698"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="864"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1104"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="916"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="947"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001736-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1136" mass="125982" checksum="76945DC6FC3F6F86" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4J6</accession>
    <name>A0A182P4J6_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A182P4J6"/>
    <dbReference type="STRING" id="199890.A0A182P4J6"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001832-RA">
        <property type="protein sequence ID" value="AEPI001832-PA"/>
        <property type="gene ID" value="AEPI001832"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001832"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000036">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2Q-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="103"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001832-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="272" mass="30109" checksum="1B8E1990571E581F" modified="2016-09-07" version="1">MSSRSKEKVTAAIRKFFKSSESKSKESKDKDGNGTHTAAPAESADPNHLPLAHHQHHHPHHPSVASVAHPAGPGASGGSSGVVAPTTTTMVHVPASKPLDTTIRSRRLMKELKEIERLQHSRTDPCFTVELINDNLYEWHARLFRIDPDSPLAEDLVELNIPFILLHLVFPENFPFAPPFMRVVEPRIEKGFVMEGGAICMELLTPRGWASAYTVEAILMQFAASLVKGQGRVSRKPKSAKDFSRRSAEEAFRSLVKTHEKYGWVTPALNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4U8</accession>
    <name>A0A182P4U8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4U8"/>
    <dbReference type="STRING" id="199890.A0A182P4U8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001935-RA">
        <property type="protein sequence ID" value="AEPI001935-PA"/>
        <property type="gene ID" value="AEPI001935"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001935"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF5">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="305"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="399"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001935-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="644" mass="70459" checksum="29905ECBEA299F1C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4V7</accession>
    <name>A0A182P4V7_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>A + NADH + H(+) = AH2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11356"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A182P4V7"/>
    <dbReference type="STRING" id="199890.A0A182P4V7"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001944-RA">
        <property type="protein sequence ID" value="AEPI001944-PA"/>
        <property type="gene ID" value="AEPI001944"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001944"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029324">
        <property type="entry name" value="AIF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF4">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14721">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01353">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="132"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial apoptosis-inducing factor C-terminal" evidence="14">
        <location>
            <begin position="460"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001944-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="67493" checksum="EB025BB08843CBA0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P4X8</accession>
    <name>A0A182P4X8_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">Epiroticus2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="199890.A0A182P4X8"/>
    <dbReference type="EnsemblMetazoa" id="AEPI001965-RA">
        <property type="protein sequence ID" value="AEPI001965-PA"/>
        <property type="gene ID" value="AEPI001965"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:AEPI001965"/>
    <dbReference type="Proteomes" id="UP000075885">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF140">
        <property type="entry name" value="FI02848P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="275"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="554"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="801"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="1061"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1197"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <begin position="1197"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <begin position="1207"/>
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    </feature>
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            <position position="249"/>
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        <location>
            <position position="1315"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00001947"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52035"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="AEPI001965-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000075885"/>
        </source>
    </evidence>
    <sequence length="1350" mass="154403" checksum="D805AEA399BCC086" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A182P531</accession>
    <name>A0A182P531_9DIPT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Anopheles epiroticus</name>
        <dbReference type="NCBI Taxonomy" id="199890"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Anopheles epiroticus epiroticus2.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Neafsey D.E."/>
                <person name="Howell P."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Epiroticus2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">Epiroticus2</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AEPI002018-PA"/>
        <property type="gene ID" value="AEPI002018"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
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        <property type="entry name" value="Znf_AD"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAIN